Gene PPP2C-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP100_AA protein Get Run
MbreP100_AA_5-292 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP2C_pd Subfamily PPP2C 6-293 2.7e-181 594.1 In-house 3-290 (290) alignment 
Range on Protein: 6-293
Range on HMM: 3-290/290.0
EVDAWLAKLRECKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFP
..|....||.|||.|||||...|..||.|||..|.|||.| ||||||||||||||||.|||.|||..|||||||.|||||||||||||||.|||||||..
dldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvryk

ERITILRGNHESRQITQVYGFYDECLRKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDRTG
|||||||||||||||||||||||||||||||.|||..|||||||.||||||..|||.|||||||..||||.||.|||.||||||||.|||||||||||.|
eritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrgg

WGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAPRRG
|||||||||.|||.|.|..||..|||.|..|||||||.||||||.||||||||||||||||||||||.||||.....||||.||||||
wgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg
subfamily_PPP6C_pd Subfamily PPP6C 6-290 3.3e-134 439.5 In-house 1-285 (290) alignment 
Range on Protein: 6-290
Range on HMM: 1-285/290.0
EVDAWLAKLRECKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFP
|.| |.   ..|| | |.....| |.  ..| .|.||||| .|||||||.||||.||.|||| ||. |||.|.|.||.|||||||.||.|.|..||...|
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

ERITILRGNHESRQITQVYGFYDECLRKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDRTG
.|||.|||||||||||||||||||||.||||.|.| ..|..|| ....|....|.. .||||||.| ||| ||...| ||.||.|..|||.||||.|   
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAP
| .||||||. ||. |.| |.. | |.|..||||||..|...  . ..||..||||||||||| |.|..|.|. ....  |.  |
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavp
0045823 Metallo-dependent phosphatases 6-291 1.4e-111 366.4 In-house 29-326 (473) alignment 
Range on Protein: 6-291
Range on HMM: 29-326/473.0
EVDAWLAKLRECKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFP
 .|...  |.... |.|.... | |.|.||| .| |....  ...|.||.|||..|| .|... |  |.....|.||.||||..|.|.. .| |||...|
dldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikyp

ERITILRGNHESRQITQVYGFYDECLRKYgNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDRTG
.....||||||.|.....|||.||.|.|| . ...  | ..... ||.|.....|.  ||||||....|| ||...|..|.|..|...|||||||..  |
gnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddg

--------WGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERN------VVTIFSAPNYCYRCGNQAAIMELDDTItQTFLQFEPAPR
        .| ||||||..||.|. . | ..|||.|. |.|. |..||.. . ..      ..|.|||||||.|.|| ||....|..   .| ||.|.| 
dgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph
0049330 Metallo-dependent phosphatases 6-292 9.5e-107 349.6 In-house 16-302 (309) alignment 
Range on Protein: 6-292
Range on HMM: 16-302/309.0
EVDAWLAKLRECKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFP
 .|... .|. .| |.|.|.. | .||.||| .| |....  ...|.||.|||..|| .|... |  |.....|.||.||||..|.|....| |||...|
lldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllyp

ERITILRGNHESRQITQVYGFYDECLRKYGnTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPD-DRT
.....||||||.|.....|||.||.|||||  ..|  |.|.....||.|.....|.  ||||||.. .|| || |.|..|.|..|..||||||||. .| 
dnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpire

GWGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAPRR
|.. .|||.|..|||.. . | ..|||.|. |.|..|..|| . ......|.|||||||.|.||..|..|.|.. . .||.|||.|. 
gfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
subfamily_PPP4C_pd Subfamily PPP4C 7-290 5.2e-143 468.5 In-house 3-286 (288) alignment 
Range on Protein: 7-290
Range on HMM: 3-286/288.0
VDAWLAKLRECKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPE
.|  ..|||.|. ..|.|..||  |||||| .|.||| | .|||||||.||||.||.|||..||..|.|||||.||.||||.|||||   |.|||||.|.
ldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypd

RITILRGNHESRQITQVYGFYDECLRKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDRTGW
|||..||||||||||||||||||||||||..||| . |..|||..|.|.....||..||||||...||| ||..|| ||||||||.||||||||.| .||
ritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaegw

GISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAP
..||||||. ||.||.. |||.|.. |..|||||||.||..  ...|.|..||||||||||| |||.|||... . |  || |.
avsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
0053225 Metallo-dependent phosphatases 7-290 3.3e-103 338.0 In-house 9-292 (293) alignment 
Range on Protein: 7-290
Range on HMM: 9-292/293.0
VDAWLAKLRECKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPE
.|...  |. .| | |.|.. | ..|.||| .| |....  ...|.||.||...|| .|... | .|.....|.||.||||..|.|....| |||...|.
ldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypd

RITILRGNHESRQITQVYGFYDECLRKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDRTGW
....||||||.......|||.||.|||||. ..|  ..|.....||.||....|.  ||||||....|| || ..|....|.||...||||||||...||
nvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsgw

GISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAP
..|.||.|..|||.. . | ..|||.|. |.||.|.||| . .....||.||||||..|.||..|...||.  . .| .|.| .
lpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP7C_pd Subfamily PPP7C 7-183 5e-35 113.9 In-house 20-202 (383) alignment 
Range on Protein: 7-183
Range on HMM: 20-202/383.0
VDAWLAKLRECKPLEESEIRALTDKAREILTHETNVQPVLC----PVTVCGDVHGQFHDLVELF-RIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALK
|.. . ...| | |    .  .  .|...| .  |.. |       ||||||.||.. ||. .. . |   .. .|.| ||.||||  ||| .  |.|| 
veklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillall

VRFPERITILRGNHESRQITQVYGFYDECLRKY--GNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDtLDAIRTLDRV
. .|. . . |||||   .   |||  |   ||   .... . . |.| ..||..|....|. .|||.| . | |. .  ..| 
lvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiers
subfamily_PPG1_pd Subfamily PPG1 8-291 5.9e-123 402.9 In-house 2-298 (300) alignment 
Range on Protein: 8-291
Range on HMM: 2-298/300.0
DAWLAKLRECKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPER
|  | ||. .. | |. ...|||| .|.| .|.||. . .|||| |||||||.|..|.|.|||..|||||||.|||||||.|||||.. |..||.|.| |
decleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsr

ITILRGNHESRQITQVYGFYDECLRKY-GNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPD-----
||.||||||||||||||||| |||||| ||..|| ..|..|||. |.|.....|. .||||||.| ..| |. ||| .|||.|| ..|||||||.     
itllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnp

-----DRTG--WGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAPR
     || |  . .|.||||...|.|| . | . | .. . |||||...||.   .  . |..|||||||||||.|.|.|| .   . |  .| ||.
tldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_PPZ_pd Subfamily PPZ 13-287 1.9e-75 247.2 In-house 18-292 (300) alignment 
Range on Protein: 13-287
Range on HMM: 18-292/300.0
KLRECKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILR
|  .   |..|||  .  ||||..  . ..  .  .| . ||||||. ||. ||   |  | .||||.|||||||  |.||.  |.. |...|| . .||
krtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllr

GNHESRQITQVYGFYDECLRKyGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDR-TGWGISPR
||||  ..|.|||||||| |.  | ..|  | | |. .||.|.|  .|| .|||||| ....| || . |  .||  | . ||||||| |    |    |
gnhecanvtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewedner

GAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFE
|  . . .   . | .. |. || ||| .| |||..  .|..||.|||||||    |  |.| . . .  .|  ..
gvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelld
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 14-291 9.8e-95 310.0 In-house 18-296 (298) alignment 
Range on Protein: 14-291
Range on HMM: 18-296/298.0
LRECKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRG
 . .| ..|...  | ..|..|... . .  |  |..||||.|||. ||. ||  .|  ||.||||.||||||| ...|... |.| ||..|... .|||
kkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrG

NHESRQITQVYGFYDECLRKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDD-RTGWGISPRG
|||  .| .|||||.|| |.| ...... | |.|. .|||||. ..|. .|||||... .|| .|.| | .. ..|    ||||.||..  .||  . ||
nheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrG

AGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAPR
....||.|| | . |.  . || ||||.| |||..  |...|||||||.|| .  | ||.|..|. .. .|  . |. .
vsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 16-289 1.8e-82 269.6 In-house 4-275 (280) alignment 
Range on Protein: 16-289
Range on HMM: 4-275/280.0
ECkpLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNH
.|  ..| .| .. .| ..||| .. .  | .||.||||.|||. ||. ||   .  ||.||||.||||||| . .| .  |.| |||.|... ||||||
ac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnh

ESRQITQVYGFYDECLRKYgNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPD-DRTGWGISPRGAG
|  .| . |||.||. |.| . .... | .|.| .||.|||  .|. .|||||... .|| .. | |  . ..|    ||||.||. . |||. ..||. 
evisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvs

FTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPA
  ||..| | . |.  . |. | ||.| |||..  ....||.||||.|.    |.||.. .|. .  .|  . ||
vifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 17-292 1.2e-86 283.6 In-house 21-297 (299) alignment 
Range on Protein: 17-292
Range on HMM: 21-297/299.0
CKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHE
 | ..| |.. | . |........ .  |  |. ||||.|||. ||. .| . |  ||.|.||.|||||||   .|..| |.. |...|||. .||||||
tksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhe

SRQITQVYGFYDECLRKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDR-TGWGISPRGAGF
   | .|||||.|| ..|  | .|. | | |...||| |. ..|. .||||||...||| .| | | |. |      ||||.|||.   .|    ||  .
cpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsy

TFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAPRR
 ||.|| .   .| .. ||.||||.| |||..  ....||||||| || .  | ||||..|. .  ||  ..|.|..
vfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 17-285 5.9e-75 245.3 In-house 20-291 (297) alignment 
Range on Protein: 17-285
Range on HMM: 20-291/297.0
CKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHE
.| . |  .  | | | ... .. ..  | .|. ||||.|||| ||. ||. ||  | .||||.||||||| .|.||.  |.| ||.||  . .||||||
skviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhe

SRQITQVYGFYDECLRKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSP---NVDTLDAIRTLDRVQEVpHEGPMCDLLWSDPD-DRTGWGISPRG
   . .|||||.|| ..|    ... | |.|...||| |. ..|. .||||||   .  |||..| ..| .|  .|. ..||||.||    .|.    ||
cefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqrg

AGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQ
||  ||.|          | || ||||.| |||..   |..||||||| || .  | ||.|  |. .  .|  
agcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfei
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 17-290 9.7e-65 211.8 In-house 3-276 (280) alignment 
Range on Protein: 17-290
Range on HMM: 3-276/280.0
CKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHE
|. .   || |.      |. .|.|.    .|. | ||.| |..|.  || . |  |. . .|.|||||||   .| .  |..||.|. .|| .||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGNTnVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDR-TGWGISPRGAGF
.  . ..|||| ||  |||   .|  |   |. .|...|. .... .||||||..  ||.|| . |  |    | . ||||||| ..  ||  | ||  .
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

TFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAP
 ||. | .   .   . |. ||||.| |||.    | ..|.|| |||| .  | ||.. |.  .  .| |. | |
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 17-288 2e-63 207.1 In-house 13-288 (290) alignment 
Range on Protein: 17-288
Range on HMM: 13-288/290.0
CKPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHE
 . .....|  . .|..|||     .  |  |... ||.|||. .|.. |   |  |. ..||.|||||||  |.|   .|  .|.|..... .||||||
ldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhe

SRQITQVYGFYDECLRKYgNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLD--RVQEVPHEGPMCDLLWSDPDD---RTGWGISPR
 |.. ..|||..|  ||  ....|  . |.|. ..| | |...|. .|||.|..... .....|   ||.   .|| . ||||.||.     |      |
vrkvnrlygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqr

GAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEP
.    ||...   . .. .| |. |||..  .|.|.  ....||.|||| |. .  |  ||... ...  ..  . |
aisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_PPP3C_pd Subfamily PPP3C 18-279 1.6e-85 280.6 In-house 39-313 (452) alignment 
Range on Protein: 18-279
Range on HMM: 39-313/452.0
KPLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHES
  |||...  . ..| ..| .| ..  |  |.||.||.||||.||..|| .||.  .|.|||.||||||||.|.|.| || |||. .|... .||||||.
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhec

RQITQVYGFYDECLRKYGnTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDRTGWGI--------S
| .|. . | .||  ||.  .|.  ... || .||.||...| . .||||||.. .|| |..||| .|.|. ||.|||||||| .. |           |
rhlteyftfkeeckikys.eevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpns

PRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHE------RNVVTIFSAPNYCYRCGNQAAIMELDDTI
.||  . ...  .  | ..| |  . |||.   .||.  ..        ..|.||||||.    |.||......  
vrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennv
subfamily_PPP1C_pd Subfamily PPP1C 19-288 5.1e-102 333.8 In-house 9-278 (282) alignment 
Range on Protein: 19-288
Range on HMM: 9-278/282.0
PLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESR
 |.|.||.||..||||||.... .  .  ||...||.|||..||. || ..|  |..||||.|||||||  |.||.. |.|.|...||.. .||||||| 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

QITQVYGFYDECLRKYGNTnVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDD-RTGWGISPRGAGFTF
.|...||||||| |.|... .|  ||| |...||.|||...|. .||||||... |. ||.. |  |||..| .|||||||||. ..||. . ||  |||
sinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftf

GHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEP
|.|| ..| ..| | |. ||||.| |||..  .|..||.||||||| . .|..|....|.... .|  . |
gkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 19-288 6.6e-71 231.6 In-house 9-281 (287) alignment 
Range on Protein: 19-288
Range on HMM: 9-281/287.0
PLEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESR
 .....|  . .|..|||     .  |  |.|..||.|||..||. .|   |  |...|||.|||||||  |.| . .| .||...|... .|||||| .
afsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevk

QITQVYGFYDECLRKYGnTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRV--QEVPHEGPMCDLLWSDPDDR-TGWGI-SPRGAG
.| ..|||..|  ||..  ...  | |.|...|| | |...|. .|||.||....|| ...| .   .   .|| . ||||.||.    .  .   |.  
kinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkirais

FTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEP
  ||. .   . .. .. |. |||... .||..  ....||.|||| |. .  | .|.. .....  .| .. |
vvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
PPP_3 20-287 3.1e-112 367.0 In-house 2-270 (271) alignment 
Range on Protein: 20-287
Range on HMM: 2-270/271.0
LEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQ
|.|.|.. |..|..|||..|.|.. .  |||||||.|||..||.|||..||..|.|.|||.|||||||..|.|....|.|||...|.....|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDL-LWSDPDDRTGWGISPRGAGFTFG
|..||||..|.|.|.|...|.. ....|...||.||...... .||||||....|| |..|.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

HDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFE
.||.. |.|.| |.|. |||.|...||.  |...|||.|||||||.|..|..||..|... |..| |.|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 20-288 6.9e-80 261.5 In-house 8-282 (284) alignment 
Range on Protein: 20-288
Range on HMM: 8-282/284.0
LEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGEC------PDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRG
|.| |.  |  .|||.. .|   . . .||...||.|||| ||. |. . |         ...|||.||||||| .|.| .| | |.|...|.....|||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESRQITQVYGFYDECLRKYGNTnVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDR-TGWGISPRG
||||| . . |||| || ..| .. ..  |   |  .||.|.|...|. .|||.| ..  |. .  |.|  ..|  | ..|| |.||. . .|.  ||||
nhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprg

AGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEP
|| .||..  | |...  | || ||||.|||||..  .|..||||||| || .  | ||....|. .  .|  ..|
agkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 20-277 2.4e-53 174.3 In-house 6-288 (302) alignment 
Range on Protein: 20-277
Range on HMM: 6-288/302.0
LEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGEC-----------PDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERI
...||. .| ..  | | .| ..  .  |||. ||.||||.||| ..    .                ..|.|||||||. |.| .. . |||| .|.. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TILRGNHESRQITQVYGFYDECLRKYGNTN---VWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDR-VQEVPHEGPMCDLLWSDPDDRT
 .||||||.. |   ||| .|   ..|...   .|  | . | ..||.||| ..|. .|||.||....|. |. ..| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGISPRGAGFT----------FGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDD
.  . ..   ..          | .   . . .| .|.|. |||| .  |...  .....||||||.|     |. |....| 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdt
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 20-277 3.6e-53 173.7 In-house 7-289 (302) alignment 
Range on Protein: 20-277
Range on HMM: 7-289/302.0
LEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGEC-----------PDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERI
...||. .| ..  | | .| ..  .  |||. ||.||||.||| ..    .                ..|.|||||||. |.| .. . |||| .|.. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TILRGNHESRQITQVYGFYDECLRKYGNTN---VWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDR-VQEVPHEGPMCDLLWSDPDDRT
 .||||||.. |   ||| .|   ..|...   .|  | . | ..||.||| ..|. .|||.||....|. |. ..| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGISPRGAGFT----------FGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDD
.  . ..   ..          | .   . . .| .|.|. |||| .  |...  .....||||||.|     |. |....| 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdt
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 20-70 2.3e-10 33.1 In-house 9-59 (317) alignment 
Range on Protein: 20-70
Range on HMM: 9-59/317.0
LEESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGG
..|.|.  |  .|||.. .|     . .|||..||.||||.||. |. . |
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
PPP_1 21-275 5.6e-110 359.7 In-house 2-264 (264) alignment 
Range on Protein: 21-275
Range on HMM: 2-264/264.0
EESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQI
||.|...| .|..|.|..|.|.. |  ..|||||.||||.||..||..||..|.|||||.|||||||..|||....|.|||...|.....|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDL--------LWSDPDDRTGWGISPRG
|.||||..|.|.|.......  .||.||..||.||....|. .||||||..|.|| ||...| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMEL
||..||.||.. |...|.|.|. |||.....||.. ..|.|||||||.||.....|..|...|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PP2Ac_SM00156 21-289 1.8e-104 341.6 In-house 2-270 (271) alignment 
Range on Protein: 21-289
Range on HMM: 2-270/271.0
EESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQI
...|...| ....|||..| |.  |  ||||.||.|||..||..|.. .||.|...|.|.|||||||..|.|....|.|||...||....|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDP-DDRTGWGISPRGAGFTFGH
...|||..|. ||| ..... .|...|...||.|||...|. .||||||.. .|| || |.||.| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPA
|. | | ..| |.|. |||..|..||.. .....||||||||||....|.||....... . .. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 22-291 2.1e-77 253.1 In-house 10-279 (281) alignment 
Range on Protein: 22-291
Range on HMM: 10-279/281.0
ESEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQIT
. || ..  ... |...| ..  .  |..| ||.|.||.|| .|| . |  |.. ..|.|||||||  |.|..  | .||.|...|| .||||||  .. 
keeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvn

QVYGFYDECLRKYGNtNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDR-TGWGISPRGAGFTFGHD
..|||| ||  |||  ..|. |   |. .|..||.....  .||||||.. .|| .|   .  . .. | . ||||.|||..  .|  | ||..||||..
kiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGkn

VSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAPR
| .    | .. |. ||||.|.|||.    |...|.||.||||    | ||.. .|.|.  ..... ||. 
vvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 23-70 6e-06 18.6 In-house 14-61 (339) alignment 
Range on Protein: 23-70
Range on HMM: 14-61/339.0
SEIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGG
.|.  |  .|||..  |  .  . .|. | ||.|||| ||. .. . |
aelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 24-290 2.6e-65 213.6 In-house 24-293 (307) alignment 
Range on Protein: 24-290
Range on HMM: 24-293/307.0
EIRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQITQV
|.  .  .|. |.. |  .  .  |. | ||.|||| ||...| . |  |.| |.| |||||||  |.|..  |.. |. .|| | .||||||  .. . 
efenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkk

YGFYDECLRKYG--NTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDR-TGWGISPRGAGFTFGHD
||||.||.        ..|. |   |. .|..||.  .|. .|||||| .  || .|   .    |  | . |.||.|||     |  | ||.||||| .
ygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtn

VSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPAP
|      | |. |. ||||...|||     |...|||||| ||    |  ... .|.|.    . | |. 
viddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 25-288 1.6e-69 227.5 In-house 8-273 (284) alignment 
Range on Protein: 25-288
Range on HMM: 8-273/284.0
IRALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQITQVY
. .|  .| .|. ..  .  |  |. .|||.|||| ||. ||   |    .||||.||||||| . .||.  |.| || ||... .||||||   | ..|
vetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiy

GFYDECLRKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPM-CDLLWSDPDD-RTGWGISPRGAGFTFGHDVS
|||.|| |.| .  |.. |  .|  .|||||| ..|. .|||.|  .. .  .|.. |  . |    .  |.||||| . . ||    ||  . || |  
gfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdal

KAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEP
. . .|  . || ||||.| |||..  .| .||||||| || .  | ||.| ..  .  .|. . |
rklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_PPPLV_pd Subfamily PPPLV 27-277 5.7e-51 166.5 In-house 4-277 (290) alignment 
Range on Protein: 27-277
Range on HMM: 4-277/290.0
ALTDKAREILTHETNVQPVLCPVTVCGDVHGQFHDLV----ELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQITQ
.| |.| .|| .| .. ..  |. | ||.||...||.     |.|.| .   ...||.||||||| .||| ..||.|||| .| .. .|||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFYDECLRKYGNT--NVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRT----LDRVQEVPHEGPM-CDLLWSDPDDRT-----------
 . .. |.  |.|..  .||  |.. ||..||.| .....|  |.|.   . |   | .    |.|...  .  |.  |.|||||..             
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

-GWG-ISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRcGNQAAIMELDD
 |.   . || |  |..|  .|| .||.|  | |||.    |..  ..  ..|.||. .||    |.||.. .| 
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdk
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 47-288 5.2e-54 176.6 In-house 7-255 (263) alignment 
Range on Protein: 47-288
Range on HMM: 7-255/263.0
CPVTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQITQVYGFYDECLRKYGNTN----VWTW
.|. .||| |||. ||. .|   | .  |.|||.||||||| .|.| .  |..||. .| .. .|||||| . | . |||. |  ...   .    |.  
apinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynh

FTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPM-CDLLWSDPDDRtGWGISP---RGAGFTFGHDVSKAFNERNGLRLVSRAH
| ..| |.|| |.| ..|. .|||.|| . .|| ||..    |  .  |. |||||.||.     |. |   |     ||.     . .|  . |. |||
fnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekd.akgfepnkiraisnvfgkkevddlckrldidlivrah

QLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEP
|.|  || .  .| ..|.|||  |     | ||.. ..  .  .|.|..|
qvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_PPP5C_pd Subfamily PPP5C 48-288 4.8e-81 265.3 In-house 66-308 (322) alignment 
Range on Protein: 48-288
Range on HMM: 66-308/322.0
PVTVCGDVHGQFHDLVELFRIGGEC-PDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQITQVYGFYDECLRKYgNTNVWTWFTDL
 .|||||.||||.||...|.. |   ..  ||| ||.|||| .|||..  |...|. .|... . |||||| .. ..||| .|.  || ...|   ||..
kltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftev

FDYFPLTALVENQIFSLHGGLSPN-VDTLDAIRTLDRVQEVPHEGPMCDLLWSDPDDRTGWGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGY
|...||. ....... .||||  .   ||| .|..|| .. |.|| ...||||||....| . | || |..|| ||.| | . |.|.|. |.|.. ..||
fnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGy

NWSHERNVVTIFSAPNYCYRCGNQAAIMEL-DDTITQTFLQFEP
. .|. ...|.||||||| . ||..|...| .|  . .| .|| 
evehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea
Metallophos Calcineurin-like phosphoesterase 48-240 1.1e-38 126.5 Pfam-A 2-198 (200) alignment 
Range on Protein: 48-240
Range on HMM: 2-198/200.0
PVTVCGDVHGQFHDL----VELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYL--VALKVRFPERITILRGNHESRQITQVYGFYDECL----------
...|.||.||...||     .|..|..|.. ...||.||.|||| .| ||  .|   .||...| ..  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLDAIrtldrvqevphegpmcdllwsdpddrtgwgi
                       .........  . . |.. || |||...|.  ||.||.  .. | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGFTFGHDVSKAFNERNGLRLVSRAHQL
    ... || |.   . |..|. || |.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 49-240 2.7e-77 252.0 In-house 1-197 (198) alignment 
Range on Protein: 49-240
Range on HMM: 1-197/198.0
VTVCGDVHGQFHDLVELFRIGGECPDTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQITQVYGFYDECLRKYGNTNVWTWFTDLFD
||||||.|||..||..||. |...|...|||.|||||||..|.|....|.|||...|.....|||||||.....||||..|.|.|.|...|.. ....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVPHEGPMCDL-----LWSDPDDRTGWGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQL
..||.||...... .|||||.....|| |.. .| .|.|.||...||     |..........  | ||||..||.||.. . |.| |.|. |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 49-240 1.1e-73 240.5 In-house 1-196 (197) alignment 
Range on Protein: 49-240
Range on HMM: 1-196/197.0
VTVCGDVHGQFHDL-VELFRIGGECP-DTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQITQVYGFYDECLRKyGNTNVWTWFTDL
|||.||.|||..|| ..|...||. . ...|.|.|||||||..|.|....|.|||...|.....|||||||......|||..|.|.|  . ... ...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVP-HEGPMCDL-LWSDPD-DRTGWGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQL
||. ||.||...... .|||||.....|| |....| .|.| .|. ..|| |||||  . .|.  | ||||..||.|| . | |.|.|.|. |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 49-240 5.5e-72 234.9 In-house 1-198 (199) alignment 
Range on Protein: 49-240
Range on HMM: 1-198/199.0
VTVCGDVHGQFHDL-VELFRIGGECP-DTNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQITQVYGFYDECLRKYGNTNVWTWFTDL
||||||.|||..|| ..||. ||. . ...|.|.|||||||..|.|....|.|||...|.....||||||..|....|||..|.|.||.. ... ...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYFPLTALVENQIFSLHGGLSPNVDTLDAIRTLDRVQEVP-HEGPMCDL-LWSDPD-DRTG-WGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQL
||. ||.||........||||||...... .. ..| .|.| ..| ..|| |||||  . .| .  | ||||..||.|| . | |.|.| |. |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 50-121 1.3e-08 27.6 In-house 13-80 (235) alignment 
Range on Protein: 50-121
Range on HMM: 13-80/235.0
TVCGDVHGQFHDLVELFR--IGGECPDTNYLFMGDYVDRGYYSVETVTYLvalkvrFPERITILRGNHESRQIT
 | ||||| . .|.||.   |||  ..   ...|| ...|  |||.| |.        .    ..||||   . 
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 75-289 2.3e-72 236.9 In-house 101-315 (317) alignment 
Range on Protein: 75-289
Range on HMM: 101-315/317.0
TNYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQITQVYGFYDECLRKYGNtNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTL
 .|||.||||||| .|.| |. |.|||...|.....|||||||| . . |||| |. ..| . ...  |   |  .||.|.|...|. .|||.| ..  |
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

DAIRTLDRVQEVPHEGPMCDLLWSDPDDR-TGWGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIM
. . .|.|  ..|  | ..|| |.||| . .|.  |.||||. ||..  |.|...  | || ||||.|.|||..  .|..|||||||.|| .  | ||..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

ELDDTITQTFLQFEPA
..|. .. ..  ..| 
svdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 76-289 6.2e-58 189.5 In-house 121-334 (339) alignment 
Range on Protein: 76-289
Range on HMM: 121-334/339.0
NYLFMGDYVDRGYYSVETVTYLVALKVRFPERITILRGNHESRQITQVYGFYDECLRKYgNTNVWTWFTDLFDYFPLTALVENQIFSLHGGLSPNVDTLD
 |||.||||||| .|.| |  | |||. .|.|| .|||||||| .   |||| |   .| .....  | ..|. ||. |...| |. .|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

AIRTLDRVQEVPHEGPMCDLLWSDPDD-RTGWGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIME
 .  . |  |.|  | . || |.|||    |.  | ||| | ||    .|| ..  |..| | ||.| |||..   | .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDDTITQTFLQFEPA
.|  .  .   | | 
idkklkisinvfrpe
subfamily_PPP7C_pd Subfamily PPP7C 192-289 5.1e-22 71.1 In-house 237-335 (383) alignment 
Range on Protein: 192-289
Range on HMM: 237-335/383.0
MCDLLWSDPDDRTG-WGISPRGAGFTFGHDVSKAFNERNGLRLVSRAHQLVMDGYNWSHERNVVTIFSAPNYCYRCGNQAAIMELDDTITQTFLQFEPA
. |.|||||  ..| .  . ||.|  || ||.| . .. .|.|. |.|.  ..||...|...|.||||| ||     |. | . | ...|  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas