Gene PPP3C-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP101_AA protein Get Run
MbreP101_AA_76-279 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045823 Metallo-dependent phosphatases 9-393 9.2e-129 423.0 In-house 2-386 (473) alignment 
Range on Protein: 9-393
Range on HMM: 2-386/473.0
ERQISWVPAPASRILDEEDIFDENGIPLVNVLCQHFKREGRLTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYL
.| ...|. | .|.|. . .|...|.. ...| .|.|.||.|. . ....||.......||||.|......|..||||||..||....   | |  ....
drvlklvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlv

FLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINS
||||.||||..|||.......||.|||||..|||||||.|.|.  . |  |. .| . ..|..... ...||.||. ......||||.||... ...|..
flGDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqire

LDRFNEPDESGALCDLLWADPHDRFDEDLGDTAFQHNETRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNPSTGFPSVITLFSAPNYLDV
..|..|....|.|.||||.|| . . ..| .. | .|  ||..|.....||. ||..| |  ..|.|.... ||...  .  .|....||.||||||...
ierpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgr

YGNKAAVMIYANNSMNIKKFSASEHPYWLPNFMDVFTWSLPFIGEKTTEMLEHLMNVCSAEELAQTNTEVDELADKMKKAMSRVK
.||.|||... .. .... | .|.||..||.|.|||..||||..|| ||.| .|.|..| .|| ... ....|  .... . | |
ggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededilglllleallellrnk
subfamily_PPP3C_pd Subfamily PPP3C 11-449 8.4e-207 680.4 In-house 2-451 (452) alignment 
Range on Protein: 11-449
Range on HMM: 2-451/452.0
QISWVPAPASRILDEEDIFDENGIPLVNVLCQHFKREGRLTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFL
....||.|.|. |.||..|||.|.| ..||..||..||||...||..|....|....||...|.| ||....||||||||||.|.|.||||||.||||||
vvkkvplpkskklteeevfdetgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylfl

GDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLD
||||||||||.|||||...||..|| ...|||||||||||||.|||..|. .|.| .||||||.|||.||.||..|.||.|||||.|||.....||..||
GdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkld

RFNEPDESGALCDLLWADPHDRFDEDLGDTAFQHNETRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNPSTGFPSVITLFSAPNYLDVYG
||.||..||.||||||.||.....|. ....|..|..|||||.|..||||.||..|.|||.||||||||||||||. . .|||||.||||||||||||| 
rfkeppasGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvyn

NKAAVMIYANNSMNIKKFSASEHPYWLPNFMDVFTWSLPFIGEKTTEMLEHLMNVCSAEELAQTNTEV--DELADKMKKAMSRVKTRR-----QSYSEVN
|||||. | ||.|||..|..|.||||||||||||||||||.|||.|||| ...|.|| .||.....|   .| .....| . | |.|      . .| . 
nkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeeeskeesesekrkevirnkiraigklarvfsvlr

ELNRKALSMAGAA---SPTGE-APSEEVIETAKQTFEGVRSLDRANESRP
| . . | . | .    |.|  .  .| .| . ..||  . ||. ||  |
eesesvlllkglttgalprgalsegkegleeklssfeeakkldlineklp
0049330 Metallo-dependent phosphatases 28-337 1.7e-90 296.3 In-house 8-305 (309) alignment 
Range on Protein: 28-337
Range on HMM: 8-305/309.0
IFDENGIPLVNVLCQHFKREGRLTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYI
...|  ..|...| ........|. . ....|. . .....|||.|......|..||||||..||....   | |  ....||||.||||..|||..|..
lllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevllll

WSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWA
..|||.||.|..|||||||.|.|. .. |  |. .| . ........ ...||.||. .....|||||.||..  ...|..|.|. |... | ||||||.
lalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllws

DPHDRFDEdlgdtaFQHNEtRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNPstgfpsVITLFSAPNYLDVYGNKAAVMIYANN-SMNIK
|| . ...      |..|  ||......| ||..||..| |  .||.|.|.. ||...  .       .||.||||||....||..||... ..  ....
dplpireg......fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisfl

KFSASEHPYWL
 | .......|
lfepvplllll
0053225 Metallo-dependent phosphatases 34-321 2.1e-84 276.4 In-house 6-280 (293) alignment 
Range on Protein: 34-321
Range on HMM: 6-280/293.0
IPLVNVLCQHFKREGRLTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLK
..|...| .....  .|.   ....|. . ....||||.|.........|||||...||....   | | .....||||.||||..|||.......|||.
lllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkll

YPGNFWLLRGNHECRHLTEFFTFQTEVGYKN-SLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDR
||.|..|||||||...|. .. |  |. .|  . ...|.... ...||.||. ......||||.||..| ...|....|. .... |.|.|||| ||...
ypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlw

FDEDLGDtafqhnetRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPnpstgfPSVITLFSAPNYLDVYGNKAAVMIYANN
..   .         ||..... | ||. ||..| |  .||.|.... ||...        ....|.|||||||...||..||... ..
sgwlpsy........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeg
subfamily_PPP5C_pd Subfamily PPP5C 36-336 5.6e-72 235.4 In-house 20-314 (322) alignment 
Range on Protein: 36-336
Range on HMM: 20-314/322.0
LVNVLCQHFKREGRLTDRAAIRILDDVADVMRKEPNVLQVPAP----VVIVGDIHGQFYDLMKVFSVGGDPATT-KYLFLGDYVDRGYFSLECVLYIWSL
.|. | ..|| . .|  . |..|| .. ....|.| ....  .    . . ||||||||||. .| . | |...  ||| ||.|||| ||.|..| ....
fvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgf

KLKYPGNFWLLRGNHECRHLTEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGI-SPEVSKVEDINSLDRFNEPDESGALCDLLWADP
|| || .|.| |||||  .. ... |. || .| .  |.|   ..|. ||.| ..|.... ||||. | .  ...|.  .||...| |.|.|..|||.||
kllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdp

HDRfdedLGdtafQHNETRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPnpstGfpSVITLFSAPNYLDVYGNKAAVMIY--ANNSMNIKK
...     |    . . .|| . ..       ||. |.|  .||.|| .. ||.. .     |  ..||.|||||| |  |||.|..    ... ...|.
qea....nG....rspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehd....G..klitvfsapnycdqmgnkgafitlrgddlklkfkt

FSASEHPYW
| | |||  
feavehpdv
subfamily_PPP7C_pd Subfamily PPP7C 37-211 2.8e-30 98.3 In-house 20-201 (383) alignment 
Range on Protein: 37-211
Range on HMM: 20-201/383.0
VNVLCQHFKREGRLTDRAAIRILDDVADVMRKEPNVLQVPA----PVVIVGDIHGQFYDLMKVFSVGGDPATT-KYLFLGDYVDRGYFSLECVLYIWSLK
|. | ..||.. .|  .  . || . ..|... ||. .| .     | . ||.||.. ||. ..   | |..   |.| ||.||||  |.| .| . .| 
veklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillall

LKYPGNFWLLRGNHECRHLTEFFTFQTEVGYKN---SLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISpEVSKVEDINSLDR
| || ...| |||||   |   . |  ||  |    .  .     . |  ||.|...... . |||||| . ...| .....|
lvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkier
subfamily_PPP2C_pd Subfamily PPP2C 43-321 1.1e-73 241.0 In-house 10-275 (290) alignment 
Range on Protein: 43-321
Range on HMM: 10-275/290.0
HFKREGRLTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLR
..|.  .|..    .. . . ....|| || .| .|| ..||.||||.||...| .||.   |.||||||||||||.|.|.| .. .||..|.    .||
klkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilr

GNHECRHLTEFFTFQTEVGYK-NSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRfdedlgdTA
|||| | .|. . |  |.  |  . .|.    . ||.||..|....| ||.|||.||... ...|..|||..|  . |.||||||.|| ||       . 
gnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr.......gg

FQhNETRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYANN
..    ||. | . ..   .| ..|.|  ..|||.    ||..   .       |.|.||||||    ||.||..   ..
wg.isprgagytfgkdisekfnktngltliarahqlvmegynwshdr......nvvtifsapnycyrcgnqaailelddk
subfamily_PPP1C_pd Subfamily PPP1C 49-321 4.3e-81 265.2 In-house 9-268 (282) alignment 
Range on Protein: 49-321
Range on HMM: 9-268/282.0
RLTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECR
.|. .   ..|.   ... ..| .|.. ||| ||||||||..||...|. .| |....||||||||||| .||| .. . ..|.||| |..|||||||. 
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

HLTEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPhdrfDEDlgDTAFQHNEtR
...... |  |.  . |  .. . .. |.|||.||..... .|||||.|||....|.|... |  | .|.| ||||||.||    |..   . ...|. |
sinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdp....dke..vlgwsend.r

GCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYANN
| |. . ...| .||..|.|  ..|||.  ..||.... .       ..|.||||||.. ..|..||.   ..
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakr......qlvtvfsapnycgefdnagavlsvdee
subfamily_PPP6C_pd Subfamily PPP6C 49-330 8.4e-69 224.9 In-house 14-283 (290) alignment 
Range on Protein: 49-330
Range on HMM: 14-283/290.0
RLTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECR
 |..  . .. | |.|.. .| ||  | .|| ..||||||||||...|  ||.   |.|.||||.|||||.||| . .. .||.||| .  |||||||.|
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

HLTEFFTFQTEVGYKN-SLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPhdrfdEDLGDtafQHNET
..|. . |  |   |  . ...  |.. || |.||||...| .|||||.||.|  ...|. ..| .|  . ||.|||.|.||     ||. .    .  .
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.....edvet...wavsp

RGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYANNS-MNIKKFSA
||  | . .| . .|.. |.|  ..|||.  . |.. .  .      ...|..|||||    || |....  ...  . | |.|
rgagylfgskvtkefvhinnlklicrahqlveeglkymfde......klvtvwsapnycyrcgnvasilaledaeereaklfka
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 50-321 5.5e-67 218.9 In-house 24-283 (298) alignment 
Range on Protein: 50-321
Range on HMM: 24-283/298.0
LTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRH
....   .... . ....| . ...| ||. . ||||||. ||...|. .| | .. ||||||||||| ..|| .. . . |.||| ||.|||||||| .
ikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhecea

LTEFFTFQTEVGYKN-SLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRFdedlgdTAFQHNeTR
. . . |. |.  .  ||..| .  . |. ||..|.. .. .|.|||.|...........| |  ...|.    |||||||..        . ...| .|
inrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenav......kgwaen.sr

GCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYANN
| |. . ...|  .||. ..  |.|||     || ..  .       ..|.||||.|.. . | ||||.  ..
GvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaek......klvtifsaphycgqfdnsaavmkvdek
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 50-324 7.7e-67 218.2 In-house 10-273 (287) alignment 
Range on Protein: 50-324
Range on HMM: 10-273/287.0
LTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRH
..|.  . .|. . ....  | .|.| ||..||||||||. ||...|   | .. ..|||||||||||  ||| .|...|||..|| .  |||||||...
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

LTEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDES--GALCDLLWADPHDrfdeDlgDTAFQHNET
. . . |. |.  | . ..|    . |. ||. |...|. .|.||||||..  ......| . . | .   |   |||||||.     |  . .|. |  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpek....d..aktfelnki

RGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYaNNSMN
|. |  . .| | ..|.. ..  ..|||| .. || ..  .       ..|.|||| |     | .||.   ..|..
raisvvfGkkevddllkkldidlivrahevseeGyaflfdk......rlvtvfsapyysgedtnlgavvvv.sksle
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 50-319 1.5e-58 191.1 In-house 16-276 (290) alignment 
Range on Protein: 50-319
Range on HMM: 16-276/290.0
LTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRH
..|.  . ||. . ....  | .|.| ||.|||||||||. .|.. |   | |   |.||||||||||  |||  |... .|..|. .  |||||||.|.
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

LTEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPD--ESGALCDLLWADPHDrfdeDLgDTAFQHNET
.  .. |. |.  | .  ..    . |. |.. | .... .|.|||||...   | ...| . . |   . |   |||||||      |  | ... |  
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptr....dk.ddtialnkq

RGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYA
|. |  . .|.. ..|..  |  ..|||| .. |. .   .       ..|.|||| |     |  |..  .
raisvvfgkkglddllkklalslivrahevkeegfnflfdk......klvtvfsapyysgndtnlgaiatvs
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 50-325 3.2e-55 180.3 In-house 8-269 (281) alignment 
Range on Protein: 50-325
Range on HMM: 8-269/281.0
LTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRH
.|..  . ..  |  .. .| .. .. .|.|.|||.|.|| || ..| . | .. ....|||||||||  |||... ...||..|. . .|||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

LTEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRFDEdlgdtaFqHNETRG
.   . |  |  .|    ..    . |. |||.| ..|.  |.|||.|||.   ...    .  .. . | . |||||||...  |      . .. .||
vnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkvee......w.kassrG

CSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYaNNSMNI
 |. . .. |     | |.  .||||    .||.. .         .||.||.||| . | | |||.   .....|
ssftfGknvvddvckrleveliirahqvvqdGyevlsgr......klitvfsvpnycafyknaaavlkv.detlgi
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 50-317 1.7e-54 178.1 In-house 23-280 (297) alignment 
Range on Protein: 50-317
Range on HMM: 23-280/297.0
LTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRH
.|.   ...||   ||.... ....| ||. ..||||||| ||...|  || | |..||||||||||| ||.| .. . . |.|.|||..||||||||  
iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

LTEFFTFQTEVGYK-NSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDES--GALCDLLWADPHDrfdedlGDTAFQHNe
. . . |  |.  . .|. .| |  . |. ||.. .. .. .|.|||.|| ..|   ...| ... . |   . ..|||||||        | . | .| 
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegkerlvadllwadpis......glsgfmen.

TRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMI
 ||.   . . ||       .|  | |||.  . || ..          ..|.|||| |   . | ||.| 
qrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagr......klvtifsaphycgqfdncaafms
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 50-328 1.7e-54 178.1 In-house 6-297 (302) alignment 
Range on Protein: 50-328
Range on HMM: 6-297/302.0
LTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGD--P---------ATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNF
..    . ... | . ..|| .. .. .|| ||||||||| ||....    .            .. |..|||||||||. |.||.  ...||. || |.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

WLLRGNHECRHLTEFFTFQTE----VGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRF-NEPDESGALCDLLWADPHDRF
 |||||||.. .   ..|. |    .| |.   ...   . |  .|.||.. .. .|||||||| .. .|||....|  .|  |     |||.||| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

--DEDLGDTAFQHNETRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVM-IYANNSMNIKKF
         ....|  || |. . . ||  . .| .|  ..|||    .|....  .       ..|.||||.|..   || ||. . .|  ..| ..
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadk......klltifsaprymnesdnkGavlkvdtngklsisvl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 50-328 2.5e-54 177.5 In-house 7-298 (302) alignment 
Range on Protein: 50-328
Range on HMM: 7-298/302.0
LTDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGD--P---------ATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNF
..    . ... | . ..|| .. .. .|| ||||||||| ||....    .            .. |..|||||||||. |.||.  ...||. || |.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

WLLRGNHECRHLTEFFTFQTE----VGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRF-NEPDESGALCDLLWADPHDRF
 |||||||.. .   ..|. |    .| |.   ...   . |  .|.||.. .. .|||||||| .. .|||....|  .|  |     |||.||| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

--DEDLGDTAFQHNETRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVM-IYANNSMNIKKF
         ....|  || |. . . ||  . .| .|  ..|||    .|....  .       ..|.||||.|..   || ||. . .|  ..| ..
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadk......klltifsaprymnesdnkGavlkvdtngklsisvl
PPP_3 51-323 3e-89 291.6 In-house 3-263 (271) alignment 
Range on Protein: 51-323
Range on HMM: 3-263/271.0
TDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHL
. . . .... ..... ||.|.... |||...||||||..||...|..||....|||||||||||||..|||..|....||.||| ...|||||||.|..
senelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

TEFFTFQTEVG-YKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHdrfdedlGDTAFQHNETRG
.. ..|..||   |.. .||..... |..||.||........||||.||.......|..|.|..|  |.|.|.|||. ...        .. . .|..||
nkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdp.......ekeeglenskrG

CSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPnpstgfPSVITLFSAPNYLDVYGNKAAVMIYANNSM
............|||.|.|  .|||||....||....        .|.|.||||||.. ..|..|..  ... .
agllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
subfamily_PPP4C_pd Subfamily PPP4C 51-322 2.1e-74 243.3 In-house 17-275 (288) alignment 
Range on Protein: 51-322
Range on HMM: 17-275/288.0
TDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHL
...   ..  .. ... .| || .| .||.. ||||||||||...| ||||   |.||||||.||||..|.|. | . .||..|| .  |.|||||.|..
keeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqi

TEFFTFQTEVGYK-NSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRfdedlgdTAFqHNETRG
|. . |  |.  |  | .|.  |.. || |..|||.... ||||||.||..|....| |.|| .|  ..|.||||||.||.|        ...     ||
tqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpeda.......egw.avsprg

CSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYANNS
  | . ...| .| |.|..  ..|||.    ||...  .      .|.|..|||||    ||.||.. . ...
agylfgsdvveqfneandielicrahqlvmegyklhfne......kvltvwsapnycyrcgnvaaileldeel
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 51-321 5.5e-50 163.4 In-house 7-264 (280) alignment 
Range on Protein: 51-321
Range on HMM: 7-264/280.0
TDRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHL
| .  | |.  |  .. .| |. .  ||. ..|||| |. |. ..| . |     | .|||||||||   .| .. .. ||..|    .|||||||   .
tgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsv

TEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRfdedlGDTAFqHnETRGC
 . . |  |. ||  . ..    . |. .|......|. .|.|||.|||. ... |  . |  || . | | ||||.|| ..     |.  | |   || 
nkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnk.....gegwf.h.sirgi

SYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYkpnpsTGFpSVITLFSAPNYLDVYGNKAAVMIYANN
|| . .  |    .  |.  .||||.  . || |      .|   .||.|| |||   . | |||..   |
symfgkgvveqacksleidliirahqvvqdgyemm.....agr.rlitvfsvpnycaqftnaaavvclnan
subfamily_PPZ_pd Subfamily PPZ 52-319 6.1e-61 199.5 In-house 27-281 (300) alignment 
Range on Protein: 52-319
Range on HMM: 27-281/300.0
DRAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLT
.   ..|     ...  .|..|..  .| ||||.|||. ||...|.  | | ...|||||||||||  ||| .| ..  |.||| ||.||||||||  .|
nseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvt

EFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRFDEdlgdtaFQHNEtRGCS
  . |  |.  .  . .. . ...|. ||.|||.  . ||||||.|| .  ...|  . |  .  . | . ||||.|| |  .|      .. || || |
rvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssne......wedne.rgvs

YYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYA
| | . |.  ||..  .  | |||   . || ...        |..|.||||||   . |  |||  .
ycynkvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvs
PP2Ac_SM00156 53-323 1.2e-92 302.8 In-house 4-261 (271) alignment 
Range on Protein: 53-323
Range on HMM: 4-261/271.0
RAAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTE
  ....|..|......|.|...| |||..|||||||..||..... .| |...||.|||||||||..|.|..|....||..|| .. |||||||......
eevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnk

FFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPhdrfdeDLGDTAFQHNEtRGCSY
...|. || .|.. ..|. ... |..||.||.......|.|||.|||.....||..|.|..|. |.| |.||||.||      .  .  ||..  ||.|.
iygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp......eqkekgfqpsk.rglsv

YYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYANNSM
.....||. ||..|.|  .|||||..| ||.... .      ...|.||||||.| ..|||||. . .|..
vFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
PPP_1 54-316 3.1e-94 308.1 In-house 5-262 (264) alignment 
Range on Protein: 54-316
Range on HMM: 5-262/264.0
AAIRILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEF
 ...... ......||.|.|.| ... ..|||||||.||.|.| |||....|.|||||||||||..|.|..|....|||||| ...|||||||.|..|. 
elaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkv

FTFQTEVG-YKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRFDEDLGDTAFQHNETRGCSY
..|..||  .| | ..|......||.||.||........||||.|||.. ...|. ..|..|  |.|.|||||..| .. ...|  .. . .| .||..|
ygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagy

YYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVM
.........||..|.| ..|||||....||...| .      .|.|.|||.|| .. .|..|..
lfgkdvtekflqknnlkliiRaHevkeeGyeflkkr......kvvtifsasnyyeegsnrgayv
subfamily_PPG1_pd Subfamily PPG1 57-321 1.3e-70 231.0 In-house 21-286 (300) alignment 
Range on Protein: 57-321
Range on HMM: 21-286/300.0
RILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTF
 . | . ... || || .. .|| .|||.||||||....| .||.   |.|||||||||||..|.| .  .  |||.||    ||||||| | .|. . |
eltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygf

QTEVGYKN--SLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRFD--EDLGDTAFQH--NETRGC
 ||.  |      |..   . || | .|||.... .|||||.||.|  ...|. ||||.|  . |||.||||.||..  .   |  |   ||  .  ||.
yteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqrga

SYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVM-IYANN
 | | .. |  ||. |..  .||||.    ||...  |       . |..|||||    ||||... .| ..
gysygkdvvekflrnndmnriirahqlcnegyqilfdn......klstvwsapnycyrcgnkasilelyekd
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 57-320 1.1e-58 191.6 In-house 13-263 (280) alignment 
Range on Protein: 57-320
Range on HMM: 13-263/280.0
RILDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTF
|... . ...  .  ...| ||| ..||.|||. ||...|.  . |  ..||||||||||| . || .| . . |..|| || .||||||. .. . . |
rviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygf

QTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRFdedlgdTAFQhNETRGCSYYYTH
. ||  . ||..|.   . .| ||..|... . .|.|||.|...  ..|.. | |  .....    |||||||...       | .  ...||.|. . .
kdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkv......tgwa.ensrgvsvifga

KAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYAN
. |  . |. ..  ..| |.  . || ..  .       ..|.||||.||. . |.|||.|  .
nvvkdltekldidliarghqvvqdgyeffadk......klvtvfsapkylgefdnsaavlivde
subfamily_PPPLV_pd Subfamily PPPLV 59-326 1.1e-54 178.8 In-house 6-283 (290) alignment 
Range on Protein: 59-326
Range on HMM: 6-283/290.0
LDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMK----VFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFF
 |   |.. .| ..|.. .|. ..||.||.. ||.     .. .| | . ...|||||||||| ||.| . |. .||. ||  ..||||||| . ..| .
cdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesi

TFQTEVGYKN--SL-SVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEV------SKVEDInsLDRFNEPDESGAL-CDLLWADPHDRFDEDL-----GD
....|  .|   || .|..| .| || ||.||..... ||||.||   .      | ..||  |.|.... .   |  |.||.|| .  |. |     ..
eykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdi..lerlkddidgaplaldilwsdpaedrdlslrgelvln

TAFQHNETRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVyGNKAAVMIYANNSMNIK
  | .|. || .. ....|. .||.||.|  |.||||....|.|. .         ..|.||. .|     |.||...  .....| 
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkg......rlltvfsssrycGs.sneaalilvdkkklrii
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 59-321 1.1e-51 169.0 In-house 12-263 (284) alignment 
Range on Protein: 59-321
Range on HMM: 12-263/284.0
LDDVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQT
| .. ... |.| ...| .|. |.||||||| ||...|   | |  ..|||||||||||   || .| ... |. .|  |..|||||||  . . . |  
lfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfye

EVGYK-NSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDR-FNEPDESGALCDLLWADPHDrFDEDlgdtaFQhNETRGCSYYYTH
|.  . |  ||| .    |  .|..|.. .. .|.|||.|  . .| .. .. | |..|.      |.||.|| . |..      ..  ..|| || .  
ecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptn.fqkg.....wn.pnsrgvsyvfgs

KAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYANN
 |.  .|.| ..  |.|||.  . || ..          ..|.|||| |   . | ||||   .|
dalrklldrlqidlvvrahqvvqdgyeffanr......rlvtifsapfycgqfdnaaavmyvnkn
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 61-321 8.8e-57 185.7 In-house 19-272 (284) alignment 
Range on Protein: 61-321
Range on HMM: 19-272/284.0
DVADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDP------ATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFF
   ... ||.  |.. ||| ||||||||| ||. .. . | |        .|||||||||||| ||.| .. ....||..| .  ||||||| | .   .
rarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqy

TFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRFDedlgdtAFQhNETRGCSYYY
 | .|   . | ..|.|   .| ..|..|...|. .|.||||| .. ...... |.|  .  . | ..|| ||||. . .       .. .  ||.   .
gfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaeve......gyk.esprgagkvf

THKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYANN
 .|||  ||.. .|  |.|||.    || ..  .       ..|.|||| |   . | |||.  ...
gakavkeflkkfkldlvvrahqvvmdgyeffadr......klvtifsapsycgqldniaavlnvdee
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 63-321 5.7e-54 176.4 In-house 37-283 (299) alignment 
Range on Protein: 63-321
Range on HMM: 37-283/299.0
ADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVGY
 .|. ... .|.| ||....||||||. ||...|.. | |  ...||||||||||   || .  .   |.||| .|..|||||||  .   . |  |.  
ksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnk

K-NSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRFDEdlgdtaFQHNeTRGCSYYYTHKAVCS
. .|  .. .  ..|. .|.. ... . .|.|||.||...... .  | | ..| .     ||||||| .   .      .. | .|| || . .. |  
rykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkd......wlan.vrgvsyvfgqdvvad

FLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYANN
 ..| ..  | |||.  . || ..  .       ..|.|||| |   . | ||.|   .|
visrldidlvarahqvvqdgyeffask......klvtifsaphycgqfdnsaaimkvden
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 63-104 7.5e-09 28.2 In-house 22-63 (317) alignment 
Range on Protein: 63-104
Range on HMM: 22-63/317.0
ADVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPAT
 ... |||  |.. ||| ||||||||| ||. .. . | | .
relfwkeplkleleapvtivGdihGqfedllalldlnGwpls
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 64-317 1.1e-39 129.5 In-house 34-277 (307) alignment 
Range on Protein: 64-317
Range on HMM: 34-277/307.0
DVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVG--
 ..  |  ....  |.|.|||.|||| ||...| . | |  | |.| ||||||| .||||.| ... |. || |  |||||||  .. . ..|  |.   
tifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvts

-YKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLWADPHDRFDEdlgdtafQHNETRGCSYYYTHKAVC
  |    ..      |. |||.|..  . .|.|||.|| .. ....    .       | . |.|||||     |        .  .||  . .  . . 
ipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfe.......wkassrgsgftfgtnvid

SFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMI
    |  .  .||||.    || .           .||.|||| | ..| |  .|. 
dvckrlgveliirahqmcfdgywvlsgr......klitifsapmycnfyknagcvlk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 64-103 1.8e-06 20.3 In-house 25-64 (339) alignment 
Range on Protein: 64-103
Range on HMM: 25-64/339.0
DVMRKEPNVLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPA
...  || .|.. ||....||||||| ||. .. . | | 
eliwsepiflkleapicvmgdihgqfddllamldmngwpl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 72-318 6.8e-47 153.3 In-house 2-242 (263) alignment 
Range on Protein: 72-318
Range on HMM: 2-242/263.0
VLQVPAPVVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVGYKNS-----L
.|.. ||. |.|| |||. ||...|   |  . |.||||||||||| .||| .. ..||||  | .. ||||||| . . . . |..|.  .        
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

SVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGAL-CDLLWADPHDrfdeDlgDTAFQHNETRGCSYYYTHKAVCSFLER
|||.   . |  .|..||..|. .|.|||||| .  ..|| ..    |  ..  | ||||||||      |     |. |. |  |  . .| |  . .|
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek....d..akgfepnkiraisnvfgkkevddlckr

NELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIY
 ..  ..|||.  . || ..          .||.|||  |     | |||.. 
ldidlivrahqvveygyaffadr......rlitvfsasryqielcnyaavvvv
Metallophos Calcineurin-like phosphoesterase 78-278 1.4e-39 129.4 Pfam-A 2-199 (200) alignment 
Range on Protein: 78-278
Range on HMM: 2-199/200.0
PVVIVGDIHGQFYDL----MKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYI--WSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVG----------
.....||.||...||    .... .....  . .|||||.||||  |.|.  .   ..|||..|....|||||||........ |  |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------YKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVEDInsldrfnepdesgalcdllwadphdrfdedl
                        ...  |..... . |..||..|. .......||..|..   ..||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

gdtafqhnetrgCSYYYTHKAVCSFLERNELLSVIRAHEAQ
            .|...  .|.. .||.. .  |.|.|. .
............gselfgpdalekllekygvdlvlrGHtHk
PPP_4 79-278 8.7e-69 224.5 In-house 1-197 (197) alignment 
Range on Protein: 79-278
Range on HMM: 1-197/197.0
VVIVGDIHGQFYDL-MKVFSVGGDPA-TTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVGYKNSLSVYDACMNSF
|..|||||||..|| .|.. .||.|. ...|.|||||||||..|||..|....|||.|| ...|||||||...|.....|..||  |.. .........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPD-ESGALCDL-LWADPHdrfdeD--LGdtaFQHNeTRGCSYYYTHKAVCSFLERNELLSVI
|.||.||........||||.|.|......|. ..|. | . |.....|| ||.||      .   |   .... .||............|||.|.| ..|
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.....eaqeg...lans.vrGagllFgpdvtekfleknnlklii

RAHEAQ
|.||..
rshelk
PPP_2 79-277 7.9e-68 221.0 In-house 1-197 (198) alignment 
Range on Protein: 79-277
Range on HMM: 1-197/198.0
VVIVGDIHGQFYDLMKVFSVGGDPATTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVG-YKNSLSVYDACMNSFD
|...||.|||..||...|..|......||||||||||||..|||..|....|||.|| ...|||||||...... ..|..||   |.. .||..... |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPDESGALCDLLwadPHDRFDEDLGDTAFQHNETRGCSYYYTHKAVCSFLERNELLSVIRAHEA
.||.||........||||.|.|......|.. .|..|  |.|.|.|||   ..... ..  .. . .|..||.............||.|.|  .|||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_5_Dcr2 79-277 1.8e-65 213.6 In-house 1-198 (199) alignment 
Range on Protein: 79-277
Range on HMM: 1-198/199.0
VVIVGDIHGQFYDL-MKVFSVGGDPA-TTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVGYK-NSLSVYDACMNS
|...||.|||..|| ...|  ||||. ...|.|||||||||..|||..|....|||.|| ...|||||||...|.|...|..||  | .. ..|... ..
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDCLPIAAIMNKQFFCVHGGISPEVSKVEDINSLDRFNEPD-ESGALCDL-LWADPHDRFDEDlgdtafQHNETRGCSYYYTHKAVCSFLERNELLSVIR
||.||.||........||||.|||. ..|... ..|. |   |.|  .|| ||.|| |. ...      . |..||........... |||.|.|  .||
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegc......klnseRGagllfgpdvtekfleknnlkliir

AHEA
.||.
shel
subfamily_YNL217W_pd Subfamily YNL217W 79-199 8.4e-07 21.7 In-house 12-139 (235) alignment 
Range on Protein: 79-199
Range on HMM: 12-139/235.0
VVIVGDIHGQFYDLMKVFS--VGGDPATTKYLFLGDYVDRGYFSLECVLYIwslklkYPGNFWLLRGNHECRHLTEFFTFQTEVGYKNS--------L--
...|||.|| . .|....   .||       ...|| ...|  |.| | |.         .   ..||||   | ..   . ..|...         |  
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

SVYDACMNSFDCLPIA-AIMNKQFFCVHGGISPE
.. .| |.    |. .  |  .. . ||.|..| 
klskadmeyarelgfsldipsdellvvhaGlvpg
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 104-320 2e-51 168.0 In-house 100-303 (317) alignment 
Range on Protein: 104-320
Range on HMM: 100-303/317.0
TTKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKV
  |||||||||||| ||.| |. . .|||.|| . .||||||| | .   . | .|| .. | ..|.|  . | .||..|..||. .|.||||| |. ..
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

EDINSLDRFNEPDESGALCDLLWADPHDRFDedlgdtAFQhNETRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAP
. .. |.|  .  . | |.|| ||||. . .       .. . .|| .  . .|||  ||.. .|  |.|||.    || ...         ..|.||||
kqldklkrpldipdvGvladltwadpdaevk......gyk.esarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadr......klvtifsap

NYLDVYGNKAAVMIYAN
.|     | |||.  ..
sycGqldniaavlsvdk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 105-317 7.3e-44 143.2 In-house 120-319 (339) alignment 
Range on Protein: 105-317
Range on HMM: 120-319/339.0
TKYLFLGDYVDRGYFSLECVLYIWSLKLKYPGNFWLLRGNHECRHLTEFFTFQTEVGYKNSLSVYDACMNSFDCLPIAAIMNKQFFCVHGGISPEVSKVE
 .||||||||||| ||.| |. . .||| ||   .||||||| | .   . |  || |.    .|..  | |. .|..|..|.  .|.|||||  .. ..
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

DINSLDRFNEPDESGALCDLLWADPhdrfdeDLGDTAFQhNETRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPN
..  . |  |  . | | || ||||      |  .  ..   .||.|. .   |. .||.. .|  ||| |.  . || ..          ..|.|||||
qfsvfkrpleipdvgvltdltwadp......dptekgyk.psargasfvfgppalraflkkldlqmvirghqvvedgyeffdgr......rlvtifsapn

YLDVYGNKAAVMI
|     | |||. 
ycgqndntaavfs
subfamily_PPP7C_pd Subfamily PPP7C 220-321 5.9e-11 34.7 In-house 236-324 (383) alignment 
Range on Protein: 220-321
Range on HMM: 236-324/383.0
ALCDLLWADPHDRfdedlgdTAFQHNETRGCSYYYTHKAVCSFLERNELLSVIRAHEAQDAGYRMYKPNpstgfpSVITLFSAPNYLDVYGNKAAVMIYA
 . |.||.||. .       .  . |  ||   |.      ..|.. .|  .||.|| .  || . . .       |.|.||| || ..  |. | .  .
qvldilwsdpkak.......eGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdk......kvltifsasnyyeeGsnrGayvklg

NN
..
kd
DUF4332 Domain of unknown function (DUF4332) 349-409 8.9e-06 12.2 Pfam-A 59-119 (122) alignment 
Range on Protein: 349-409
Range on HMM: 59-119/122.0
PFIGEKTTEMLEHlMNVCSAEELAQTNteVDELADKMKKAMSRVKTRRQS---YSEVNELNRKA
. ||..  |.||.   | ...||||.|  ..|| .|...     |..||     ..|... ..|
kgigpeyaeLLea.aGvdtvkeLaqrn..pqeLhqklgrlnrslklkrqlvpslaqvkkWieqA