Gene PPP6C in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP6C
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP106_AA protein Get Run
MbreP106_AA_1-292 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP4C_pd Subfamily PPP4C 1-288 3.6e-148 485.4 In-house 1-287 (288) alignment 
Range on Protein: 1-288
Range on HMM: 1-287/288.0
MDVDQWVELVKDCKYLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKY
.|.|. .| ...|. . |.|.||||.|..|||.||. ||.| |||||||||||||||| |||. ||.||.| |.|.|||||||.||.|||  ||.||..|
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

PDRMVLLRGNHETRQITQAYGFYDECLQKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDEIE
|||..|.|||||.|||||.||||||||.|||..| |.|||||||.||.||.||..|.||||||||.. |.|.||.|.|.||.||||..|||.||||...|
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

TWLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHFENnALATVWSAPNYCYRCGNVASILEINEKLEQHPIFFEAVPE
.| ||||||||||||.||..|.. | ..|||||||||.|| ..||..  . ||||||||||||||||.|||..|.|...   |||...
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfne.kvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaa
subfamily_PPP6C_pd Subfamily PPP6C 2-291 3.7e-173 567.4 In-house 1-289 (290) alignment 
Range on Protein: 2-291
Range on HMM: 1-289/290.0
DVDQWVELVKDCKYLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYP
..|.|.||.|.|||||||.||.||..|...||||..||.|||||||||||||||||||||||.|||||||.|.|.|||||||.|||||||||||||||||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

DRMVLLRGNHETRQITQAYGFYDECLQKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDEIET
||..|||||||.|||||.||||||||.||||.|||||||.|||||..||.||.|.||||||||||| |.||||.|||.|||||.|||||||||||...||
dritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvet

WLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHFENNaLATVWSAPNYCYRCGNVASILEINEKLEQHPIFFEAVPEEKR
| ||||||||||||||..||..||.|||||||||||.|||.|.|... |.|||||||||||||||||||..... |... .|.|||.|.|
wavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdek.lvtvwsapnycyrcgnvasilaledaeereaklfkavpdeer
subfamily_PPP2C_pd Subfamily PPP2C 2-288 1.1e-134 441.2 In-house 3-288 (290) alignment 
Range on Protein: 2-288
Range on HMM: 3-288/290.0
DVDQWVELVKDCKYLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYP
|.|...| .|.|| | |.|.|.|| |. ||| .|  || |..|||||||.||||.|| |||. ||..||| |.|.||.||||.||.|| | | .|| .|.
dldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvryk

DRMVLLRGNHETRQITQAYGFYDECLQKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDEIET
.|...||||||.||||| ||||||||.||||.| ||| |..|| |...||.|.||.|.|||||| . |.|.||...| ||.||||..|||.|||||. . 
eritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrgg

WLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHFENNaLATVWSAPNYCYRCGNVASILEINEKLEQHPIFFEAVPE
| .||||||| || ..  .| . |.|.|| |||||| || .. ...| ..|..||||||||||| |.|||...||... . |.. |.
wgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrn.vvtifsapnycyrcgnqaailelddklkysflqfdpapr
0045823 Metallo-dependent phosphatases 2-292 8.4e-116 380.3 In-house 29-330 (473) alignment 
Range on Protein: 2-292
Range on HMM: 29-330/473.0
DVDQWVELVKDCKYLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYP
|.|...|  | ...|||..|. |.... ||| .| ... .| ...|.||||||..||..|... |  |.....|.||.||||..|||.. .|| || |||
dldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikyp

DRMVLLRGNHETRQITQAYGFYDECLQKYgNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDEIET
....|||||||.|.....|||.||.|.|| . . .... |... | .||.|...||.||||||||.|..||||.||| .|||..|...||.||||.|.. 
gnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPweddg

--------WLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHFENNA-----LATVWSAPNYCYRCGNVASILEINEKLeQHPIFFEAVPE
        .  |||||||||| ..| ||.. | |.||.|.|. |.|| ...| ...     ..||.||||||.|.|| |..|.|.|.|  ..| |...| 
dgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph

EKRN
... 
plil
0053225 Metallo-dependent phosphatases 2-288 5.6e-105 343.8 In-house 8-293 (293) alignment 
Range on Protein: 2-288
Range on HMM: 8-293/293.0
DVDQWVELVKDCKYLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYP
..|...||.. .|.|.|.||. |. .. |||..|.... .| ...|.|||||...||..|... | .|.....|.||.||||..|||....|| ||..||
lldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllyp

DRMVLLRGNHETRQITQAYGFYDECLQKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDEIET
|..||||||||.......|||.||.|.|||... |........ | .||||...||.||||||||....|||| |.|...||.||...||.|||||....
dnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsg

WLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHFEnNALATVWSAPNYCYRCGNVASILEINEKLEQHPIFFEAVPE
|| |.||.|..||  .| .|...| |.||.|.||.|..|....|. . | ||.|||||..|.||....|...|.|  ....|..|.|
wlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfd.gklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvle
0049330 Metallo-dependent phosphatases 3-291 1.2e-108 355.8 In-house 17-304 (309) alignment 
Range on Protein: 3-291
Range on HMM: 17-304/309.0
VDQWVELVKDCKYLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPD
.|...||.. .|.|.|.||. |. |. |||..|.... .| ...|.||||||..||..|... | .|.....|.||.||||..|||....|| || .|||
ldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypd

RMVLLRGNHETRQITQAYGFYDECLQKYGnSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPD-EIET
...|||||||.|.....|||.||.|.||| .. |........ | .||.|...|||||||||||....|||| .|| .|||..| .|||.||||. ..|.
nvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpireg

WLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHFEnNALATVWSAPNYCYRCGNVASILEINEKLEQHPIFFEAVPEEKR
.. .|||.|..||  .| .|...| |.||.|.|..|..| ...|. . | ||.||||||.|.||....|||.|.|. ....||.|| . .
fapnprglgvvfghtaverflkkngldliirghgavfgGyltffd.gklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
subfamily_PPG1_pd Subfamily PPG1 4-290 1.4e-122 401.6 In-house 2-300 (300) alignment 
Range on Protein: 4-290
Range on HMM: 2-300/300.0
DQWVELVKDCKYLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDR
|. .| .. .. |||  .|.|. |. |.|..|  |. . ||||| ||.||||||. |.|. ||||||| |.|.||.||||.||.|| . |..|| .|| |
decleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsr

MVLLRGNHETRQITQAYGFYDECLQKY-GNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPD-----
. |||||||.|||||.|||| |||.|| |||. ||| ||.|| |..||.||..| ||||||||.| ..|||. ..| .|.|.|||..||.||||.     
itllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnp

-------EIETWLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHFENnALATVWSAPNYCYRCGNVASILEINEKLEQHPIFFEAVPEEK
       | . . ||.||||| .| .|| .| . | .. | |||||..|| | .|.|  |.|||||||||||||| |||||..||.|..   .|. ||.|
tldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdn.klstvwsapnycyrcgnkasilelyekderyfnvyeeapesk
subfamily_PPP5C_pd Subfamily PPP5C 4-288 1.8e-76 250.2 In-house 22-311 (322) alignment 
Range on Protein: 4-288
Range on HMM: 22-311/322.0
DQWVELVKDCKYLPENELKALCSKVSEILLEEGTVQTVSS----PVTVCGDIHGQFYDLEELFRHGGQV-PDTTYIFMGDFVDRGHYSLETFTRLLTLKA
.. .||.|. |.|..    .. ....|.| .. ..  ..      .||||||||||||| ..|.  |.. .. .|.| ||||||| .|.|.   ||..| 
kellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkl

KYPDRMVLLRGNHETRQITQAYGFYDECLQKYGNsNAWKYCTEVFDLLSVAALIDDQILCVHGGL-SPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPD
 ||... | |||||. .. . ||| .|. .|| . .  .  ||||. | .| .|....| ||||| | |  |.|..|.|.| .. |.||....|.||||.
lyPnhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq

EIETWLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHfENNALATVWSAPNYCYRCGNVASILEI-NEKLEQHPIFFEAVPE
| .    | || |  ||  | ..|.. | |.|| |.|.. .|| . . ..  | ||.|||||| . || ...... ...|. .   ||||. 
eanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyeve.hdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeaveh
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 11-277 2.4e-86 282.5 In-house 19-285 (298) alignment 
Range on Protein: 11-277
Range on HMM: 19-285/298.0
KDCKYLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGN
| .| . |.... |.... .|. .  ..  | .|..||||||||. ||  || ..|  ||. |.|.||.||||...||. . ||. |.|||....|||||
kltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGn

HETRQITQAYGFYDECLQKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDE-IETWLVSPRGA
||. .| . ||||.|| ..| . . ..   .||. | ..||| ..|||.|||||. . ..||.|...| .. ..|    ||.|.||.. .. |  . ||.
heceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkgwaensrGv

GYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKLE
.. ||..|| ....  .. |..||||.||.| .. | .. | |..|||.|| .  | |......|||.
svvfGedvvkdllekldidlvvrahqvvqdGyef.faekklvtifsaphycgqfdnsaavmkvdeklv
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 13-277 5.2e-66 216.0 In-house 3-266 (280) alignment 
Range on Protein: 13-277
Range on HMM: 3-266/280.0
CKYLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHE
|. .   |. |.   |  |..||  .    .|. | |||| |. |.. ||   |.||.   .|.||.||||   .| .  |. || .| ||. |||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

TRQITQAYGFYDECLQKYGNSNAWKYCTeVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPD-EIETWLVSPRGAGY
|  . . |||| ||  |||    | . . .|. . ...||  ..||.||||||..  .| || | |  |    | . ||.||||  . | |. | ||  |
tpsvnkiygfyvecqykygvglwwdfqs.cfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

LFGSKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKLE
.||  || . |.   . || ||||.||.| .  .    | ||.| |||| .  | |... .| .|.
mfgkgvveqacksleidliirahqvvqdgyem.magrrlitvfsvpnycaqftnaaavvclnanlq
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 14-277 3.8e-75 246.0 In-house 6-274 (284) alignment 
Range on Protein: 14-277
Range on HMM: 6-274/284.0
KYLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQV------PDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLL
| | |.||  || .  |.. .|   . . .||...||||||| ||  |.   |         .. |.|.||.|||| .|.|  | |...| ..||...||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHETRQITQAYGFYDECLQKYGNSnAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPD-EIETWLVSP
|||||.| . . |||| || ..| ..  ..     |  . ..|.....|.|.|||.| |.  ..|.  .||  .||  |  .||.|.||. |.|..  ||
rgnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesp

RGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKLE
|||| .||.| | ||..   |.|. ||||.|..| .. | .. | |..||| || .  |.|..|...|.|.
rgagkvfgakavkeflkkfkldlvvrahqvvmdgyef.fadrklvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 15-63 1.7e-10 33.6 In-house 8-56 (317) alignment 
Range on Protein: 15-63
Range on HMM: 8-56/317.0
YLPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFR
 . |.||  || .  |.. .|     . .|||..||||||| ||  |. 
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalld
PPP_3 16-283 7.3e-112 365.8 In-house 2-269 (271) alignment 
Range on Protein: 16-283
Range on HMM: 2-269/271.0
LPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQ
|.||||| |..|..||| .| .....|.|||||||||||..|| |||..||..|.|.|.|.||.||||..|||... ||.|| |||....|||||||.||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQAYGFYDECLQKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDL-VWSDPDEIETWLVSPRGAGYLFG
|.. |||..|.|.|.|... .|...|||.||..|||||...|.|||||||.. ..|||...|| .|.|.||...|| ..|||.. |..  |.||||.|||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

SKVVSEFCNINSLKLICRAHQLVQEGLQYHFEnNALATVWSAPNYCYRCGNVASILEINEKLEQHPIFF
..|..||.. |.||||.|||.|..|| ..... . . ||.||||||.|..|...||...|.|.... ..
pdvteefleknkLkliiRaHelkeeGyeilhd.gkvvtvfSapnycerasnagailkleealtsefkql
subfamily_PPP1C_pd Subfamily PPP1C 16-277 8.2e-99 323.3 In-house 10-270 (282) alignment 
Range on Protein: 16-277
Range on HMM: 10-270/282.0
LPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQ
| |.|..||..|  ||||.. .. ... ||...||||||..||  || ..|  |...|.|.||.||||. |||| . ||..| |||... |||||||. .
lkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesas

ITQAYGFYDECLQKYGNSnAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDE-IETWLVSPRGAGYLFG
|.. ||||||| ..|..   ||  |.||. | .|||.|..||||||||||..  ..|||.|.|  |.|..|  |||.|||||. ...|  . ||  . ||
inriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsftfg

SKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKLE
..||..|.. | |.||.||||.|..| .. |... | ||.|||||| . .| ...|...|.| 
kdvvekflqkndldlivrahqvvedGyef.fakrqlvtvfsapnycgefdnagavlsvdeell
subfamily_PPP3C_pd Subfamily PPP3C 16-274 4.8e-79 259.2 In-house 41-311 (452) alignment 
Range on Protein: 16-274
Range on HMM: 41-311/452.0
LPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQ
| |..   . ......| .| |. .|..|.||.|||||||||| .||  ||.  .|.|.|.||.|||| .|.|.   |..|| .||... |||||||.| 
leeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrh

ITQAYGFYDECLQKYGNsNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDE-I------ET-WLVSPR
.|. . | .|| .||.. . .. |.| || | .|||...| |||||||||.. ..|.|....| .|.|. |..|||.|||| |        |.    |.|
lteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvr

GAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHFENN-----ALATVWSAPNYCYRCGNVASILEINE
|  |... | |.|| . | |  | |||.  ..| . . ...     .| |..|||||.    | |..|....
GcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 16-276 6.1e-77 251.8 In-house 24-284 (299) alignment 
Range on Protein: 16-276
Range on HMM: 24-284/299.0
LPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQ
. |.||. ||.   ...... ..  | .|. ||||||||. ||  .| . |  ||. ..|.||.||||   ||. | ||  | |||.|. .||||||   
vkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpa

ITQAYGFYDECLQKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDE-IETWLVSPRGAGYLFG
| . ||||.|| ..|  .  |    . |. . .. ||  .|||.|||||| . |.||.| . | |. |      ||.|.|||. .  ||   ||  |.||
inrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvfg

SKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKL
 .||.. ..   . |..||||.||.| .. | .. | |..||| || .  | |.|....|.|
qdvvadvisrldidlvarahqvvqdgyef.faskklvtifsaphycgqfdnsaaimkvdenl
subfamily_PPZ_pd Subfamily PPZ 16-276 1.7e-69 227.7 In-house 25-284 (300) alignment 
Range on Protein: 16-276
Range on HMM: 25-284/300.0
LPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQ
| ..|.  .| |  |..| . ..  .| .| . ||.|||. ||  || . |  | . |.|.||.||||. ||||   ||  | |||. ..|||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQAYGFYDECLQKyGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDP-DEIETWLVSPRGAGYLFG
.|. ||||||| ..  | . ||   . |. | .||..  .|.|||||||| . ..|.|| . |  ..|  |   ||.|||| |  . |    ||  | . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

SKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKL
   . .| |   . |.|||| .|..| .. |.. .| ||.||||||    |  ... ..| |
kvainkflnkfgfdlvcrahmvvedgyef.fndrslvtvfsapnycgefdnwgavmsvsegl
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 16-276 7.6e-63 205.6 In-house 3-264 (284) alignment 
Range on Protein: 16-276
Range on HMM: 3-264/284.0
LPENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQ
.| .....|  .. .|. ..  .  | ||. .|||||||| ||  || . |    . |.|.||.||||.. |||   |.. |  .|.....||||||   
ippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecsl

ITQAYGFYDECLQKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAF-CDLVWSDPDEIE-TWLVSPRGAGYLF
| . ||||.|| ..| .   ..    ||  . ..||. ..|||.|||.|  .  | |.|.|.|  . |   ..  |..|||| ...  |    ||  |.|
inkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvf

GSKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKL
||  . .. .   . |. ||||.||.| .. | |  | |..||| || .  | |... .|..|
gsdalrklldrlqidlvvrahqvvqdgyef.fanrrlvtifsapfycgqfdnaaavmyvnknl
PP2Ac_SM00156 17-284 1.9e-101 331.7 In-house 2-268 (271) alignment 
Range on Protein: 17-284
Range on HMM: 2-268/271.0
PENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQI
 ..|...|...| ||| .| ..  ||.||||.||||||..|| .|.. .|..|...|.|.||.||||..|.|. . |..|| .||...||||||||....
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQAYGFYDECLQKYgNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDP-DEIETWLVSPRGAGYLFGS
...|||..|. .|| ...... ..|.|.||..|||.|..|||.||||||.. ..|.|| ..| .|.|.|| ..||.|||| .. ...  | ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

KVVSEFCNINSLKLICRAHQLVQEGLQYHFENnALATVWSAPNYCYRCGNVASILEINEKLEQHPIFFE
..|.||.. | ||||.|||..|.|| .. ...  | |..||||||....|.|..|.....|. . . ..
davkeflkknnlkliiRahevvdeGyeffadk.klvtifsapnycdefsnkaavlkveknlklsieqlk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 17-279 1.8e-75 246.7 In-house 9-270 (281) alignment 
Range on Protein: 17-279
Range on HMM: 9-270/281.0
PENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQI
 ..|....  .|  |. || ..  . .|..| ||.|.|| ||..||   |.||.. ..|.||.||||  |||..  |.||| .|.||.||||||||. ..
tkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasv

TQAYGFYDECLQKYGNsNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDE-IETWLVSPRGAGYLFGS
 . |||| ||  |||  . |    . |. | ..|||. ..||.||||||.. . |..| . .  . .. |   ||.|.|||.  | |  | ||....|| 
nkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGk

KVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKLEQH
.|| . |    . || ||||.||.| .  ..   | ||.|.||||    | |..| ..|.|. .
nvvddvckrleveliirahqvvqdGyev.lsgrklitvfsvpnycafyknaaavlkvdetlgis
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 17-286 1.7e-74 243.4 In-house 7-272 (280) alignment 
Range on Protein: 17-286
Range on HMM: 7-272/280.0
PENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQI
 | .....  |. .||. . |.  | .||.||||.|||. ||  || . .  ||. |.|.||.||||.. ||    ||. |..||.....||||||. .|
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

TQAYGFYDECLQKYGNsNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPD-EIETWLVSPRGAGYLFGS
 . |||.||. ..| . . ..   |..| | ..||.  .|||.|||||... ..|... . |  . ..|    ||.|.||. ..  |  ..||. ..||.
nrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifga

KVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKLEqhpIFFEAV
.|| ....   . ||.| ||.||.| .. | .. | ||.|||.|.    | |..| ..|.|.   . || .
nvvkdltekldidliarghqvvqdgyef.fadkklvtvfsapkylgefdnsaavlivderli...vsfevl
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 17-274 5.1e-53 173.2 In-house 7-288 (302) alignment 
Range on Protein: 17-274
Range on HMM: 7-288/302.0
PENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQ-----------VPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMV
 ..|| .|...| | | .| |. ..|.|||. ||||||| ||  .. .  .                ..|.||.||||. |.|  . ...||  || . .
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LLRGNHETRQITQAYGFYDECLQKYGNSN---AWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERC-QEIPHEGAFCDLVWSDPDEIET
||||||||. |  |||| .|  ...|...    |.   |||  . .|||. ..|||||||.|| . ....|. |.|  .|. ..    ||...|| ....
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

WLVSP----------RGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINE
  . .          ||  ..|    | ..|.  .|||| |||| . || .. | .. | |..|||.|     |  ..|... 
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkf.fadkklltifsaprymnesdnkGavlkvdt
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 17-274 7.5e-53 172.7 In-house 8-289 (302) alignment 
Range on Protein: 17-274
Range on HMM: 8-289/302.0
PENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQ-----------VPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMV
 ..|| .|...| | | .| |. ..|.|||. ||||||| ||  .. .  .                ..|.||.||||. |.|  . ...||  || . .
sksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyi

LLRGNHETRQITQAYGFYDECLQKYGNSN---AWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERC-QEIPHEGAFCDLVWSDPDEIET
||||||||. |  |||| .|  ...|...    |.   |||  . .|||. ..|||||||.|| . ....|. |.|  .|. ..    ||...|| ....
llrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvql

WLVSP----------RGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINE
  . .          ||  ..|    | ..|.  .|||| |||| . || .. | .. | |..|||.|     |  ..|... 
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkf.fadkklltifsaprymnesdnkGavlkvdt
PPP_1 18-271 2.9e-103 337.8 In-house 3-263 (264) alignment 
Range on Protein: 18-271
Range on HMM: 3-263/264.0
ENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQIT
|.||..|..|..|.| .| ....||...||||||||||.|| .||. ||..|.|.|.|.||.||||..|.|... ||.|| |||... |||||||.||.|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

QAYGFYDECLQKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDL--------VWSDPDEIETWLVSPRGA
. |||..|.|.|..... .|..|.|||.|..|||||..||.|||||||.. ..||||...| .|.|.||..|||        ...|... |..  |.|||
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

GYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHFeNNALATVWSAPNYCYRCGNVASILE
|||||..|...|.. | ||||.|||....|| .... .. . |..||.||.....| .....
gylfgkdvtekflqknnlkliiRaHevkeeGyeflk.krkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 18-61 1.9e-06 20.2 In-house 13-56 (339) alignment 
Range on Protein: 18-61
Range on HMM: 13-56/339.0
ENELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEEL
  ||  || .  |..  |  .  . .|. | ||||||| ||  .
aaelaelchrareliwsepiflkleapicvmgdihgqfddllam
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 19-286 3.8e-59 193.4 In-house 23-292 (307) alignment 
Range on Protein: 19-286
Range on HMM: 23-292/307.0
NELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQ
.|.. .  .   |.  | ..  .  |. | ||.|||| || ..|   |. |.| |.| ||.||||  |||.   |.| |  ||. .||||||||  .. .
eefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnk

AYGFYDECLQKYGN--SNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDLVWSDPDE-IETWLVSPRGAGYLFGS
 ||||.||.    .   . |     .|. | ..|||  .|||.|||||| .  .|..|   .    |  |   |..|.|||  .  |  | ||.|. ||.
kygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgt

KVVSEFCNINSLKLICRAHQLVQEGLqYHFENNALATVWSAPNYCYRCGNVASILEINEKLEQHPIFFEAV
.|. . |.   ..|| ||||.. .|  . .    | |..||| ||    |   .| ..| |  . . |   
nviddvckrlgveliirahqmcfdgy.wvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpe
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 20-278 1.8e-68 223.6 In-house 14-274 (287) alignment 
Range on Protein: 20-278
Range on HMM: 14-274/287.0
ELKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQA
..  .  |. |||    ..  | .|.|..||||||. ||  .|   |. |.. |.|.||.||||  |||    |..|| .|| .. ||||||| ..| . 
dilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinkl

YGFYDECLQKYGnSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEI--PHEGAFCDLVWSDPDE-IETWL-VSPRGAGYLFGS
|||..|  .|.. .. .|   .||. |.. | .. .|||.|||.||.. ..|....... .     .||   ||.|.||..  .|      |.   .|| 
yGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfGk

KVVSEFCNINSLKLICRAHQLVQEGLQYHFENnALATVWSAPNYCYRCGNVASILEINEKLEQ
|.| ....  ...|| |||....|| .. |..  | ||.||| |. .  |..... ... || 
kevddllkkldidlivrahevseeGyaflfdk.rlvtvfsapyysgedtnlgavvvvskslel
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 21-277 7.2e-68 222.0 In-house 28-286 (297) alignment 
Range on Protein: 21-277
Range on HMM: 28-286/297.0
LKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQAY
.  |     ...  . ..  | .|. ||||||||| ||  ||..||  | . |.|.||.||||..|.||   ||. | |.|  ..|||||||   . ..|
vlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvy

GFYDECLQKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSP---DVPTVDQIRTIERCQEiPHEGAFCDLVWSDPD-EIETWLVSPRGAGYLFGSK
|||.|| ..|     .    .||. | .. || ..|||.||||||   .  |.| .| ||| .|  .|.  .||.|.||   .  ..   ||||  ||  
gfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfmenqrgagcgfgrd

VVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKLE
 | . |    | |.|||||.||.| .. |    | |..||| || .  |.|...  .|||.
avlklcsefkldlvcrahqvvqdgyef.fagrklvtifsaphycgqfdncaafmscdeklq
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 21-277 3.6e-62 203.0 In-house 21-280 (290) alignment 
Range on Protein: 21-277
Range on HMM: 21-280/290.0
LKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQAY
.  .  |. |||    ..  | .|... ||||||. .| . | . |. |.  ..|.||.||||  |||    |. .| .|. .. |||||||.|.. . |
ileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrly

GFYDECLQKYgNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERC--QEIPHEGAFCDLVWSDPDE--IETWLV-SPRGAGYLFGS
||..|  .|  .|. ||   .||. ||. | .. .|||.|||.|... . . ......   .   .||   ||.|.||..   .|  .   |.   .|| 
gfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfgk

KVVSEFCNINSLKLICRAHQLVQEGLQYHFENNaLATVWSAPNYCYRCGNVASILEINEKLE
|.. ....  .|.|| |||.. .|| .. |... | ||.||| |. .  |. .|... | ||
kglddllkklalslivrahevkeegfnflfdkk.lvtvfsapyysgndtnlgaiatvsesle
subfamily_PPPLV_pd Subfamily PPPLV 21-276 7.7e-51 166.1 In-house 2-280 (290) alignment 
Range on Protein: 21-276
Range on HMM: 2-280/290.0
LKALCSKVSEILLEEGTVQTVSSPVTVCGDIHGQFYDLE----ELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQI
| .||..  .||..|  .  . ||. | ||.||.. ||      |.| | ..  ....|.||.||||..|.|  . ||.||  || ...||||||| . .
llslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesv

TQAYGFYDECLQKYGNS--NAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQE---IPHEGA--FCDLVWSDPDEI-----ETWLV
.... .. |.  |.|.|  ..|.  ..||| | .|| ||....|||.|.   . |  .| .|.   |    . .||    |..||||.|       . ||
qesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelv

S--------PRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHfENNALATVWSAPNYCYRCGNVASILEINEKL
          || |..|... .  | . |.|. . |||.  ..|...  ..  | ||.|. .||    . | ||  ..||
lneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlq.qkgrlltvfsssrycGssneaalilvdkkkl
subfamily_PPP7C_pd Subfamily PPP7C 39-179 1.3e-33 109.3 In-house 59-202 (383) alignment 
Range on Protein: 39-179
Range on HMM: 59-202/383.0
Q-TVSSPVTVCGDIHGQFYDLEELFRH-GGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQAYGFYDECLQKY--GNSN
. ..|  ||||||.||.. ||  ..   |   .. .|.| |||||||. |.|    ||.|   ||  . | |||||   .   |||  |  .||   ...
staiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkk

AWKYCTEVFDLLSVAALIDDQILCVHGGLSpDVPTVDQIRTIERC
  .   .||  | .|.|||..|| ||||.| |   .. .  ||| 
ilrlledvfawlplatlidekilivhGGis.dktdlelldkiers
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 41-279 6.4e-50 163.2 In-house 5-249 (263) alignment 
Range on Protein: 41-279
Range on HMM: 5-249/263.0
VSSPVTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQAYGFYDECLQKYGNSNA----W
. .|. .||| |||. ||  .|   |    | |.|.||.|||| .|||    |..||   | .| ||||||| . | . |||. |  ...   .     .
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

KYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHE-GAFCDLVWSDPDEIETWLV--SPRGAGYLFGSKVVSEFCNINSLKLICRA
..  .||  . ..|..  .|||.|||.|| . ..|.||.|    |  .     |||.|.||..    .     |    .|| | | ..|.   . || ||
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivra

HQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASILEINEKLEQH
||.|. |  . | .  | ||.||  |     | |... .|. ||  
hqvveygyaf.fadrrlitvfsasryqielcnyaavvvvnkmlels
Metallophos Calcineurin-like phosphoesterase 44-236 1.2e-46 152.5 Pfam-A 2-198 (200) alignment 
Range on Protein: 44-236
Range on HMM: 2-198/200.0
PVTVCGDIHGQFYDL----EELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRL--LTLKAKYPDRMVLLRGNHETRQITQAYGFYDECL----------
...|.||.||...||    ..|...... . ....|.||.|||| .|.||. .|  | || ..|.. .||||||| .....||||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------QKYGNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVDQIrtiercqeiphegafcdlvwsdpdeietwlv
                        .... .|. .. |.|..|. .||.| .||..||.||..  ..|.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYLFGSKVVSEFCNINSLKLICRAHQL
    ...|||......... . ..|..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_YNL217W_pd Subfamily YNL217W 44-117 3.5e-07 23.0 In-house 11-80 (235) alignment 
Range on Protein: 44-117
Range on HMM: 11-80/235.0
PVTVCGDIHGQFYDLEELFR--HGGQVPDTTYIFMGDFVDRGHYSLETFTRLltlkakYPDRMVLLRGNHETRQIT
 . | ||.|| . .| ||.    ||. .. . ...||....|  |.|.   .        |    ..||||   . 
rllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
PPP_2 45-236 9.9e-79 256.6 In-house 1-197 (198) alignment 
Range on Protein: 45-236
Range on HMM: 1-197/198.0
VTVCGDIHGQFYDLEELFRHGGQVPDTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQAYGFYDECLQKYGNSNAWKYCTEVFD
||||||.|||..|| .||..|...|...|.|.||.||||..|||... ||.|| .||....|||||||...... |||..|.|.|.|.....|...|||.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

LLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIPHEGAFCDL-----VWSDPDEIETWLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQL
||..|||||...|.||||||... ..|||...|| .|.|.||...||     ....... |..  | ||||.|||..|..|... |.||||.|||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 45-236 2.7e-74 242.5 In-house 1-196 (197) alignment 
Range on Protein: 45-236
Range on HMM: 1-196/197.0
VTVCGDIHGQFYDL-EELFRHGGQVP-DTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQAYGFYDECLQKyGNSNAWKYCTEV
|||.||||||..||  .|.. ||. . .. |.|.||.||||..|||... || || .||...||||||||...... |||..|.|.|  .....|....|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIP-HEGAFCDLV-WSDPD-EIETWLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQL
||||..|||||...|.||||||... ..|.|..||| .|.| .|....||  ||||  . |..  | ||||.|||..|...|.. | ||||.|.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 45-236 2.3e-73 239.4 In-house 1-198 (199) alignment 
Range on Protein: 45-236
Range on HMM: 1-198/199.0
VTVCGDIHGQFYDL-EELFRHGGQVP-DTTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQAYGFYDECLQKYGNSNAWKYCTEV
||||||.|||..||  .||..||. . .. |.|.||.||||..|||... || || .||....|||||||..|... |||..|.|.||......|....|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDLLSVAALIDDQILCVHGGLSPDVPTVDQIRTIERCQEIP-HEGAFCDLV-WSDPD-EIET-WLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQL
|| |..|||||...|.|||||||.. ...... ||| .||| ..|  .||. ||||  . |. .| | ||||.||| .|...|.. | ||||.|.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 71-278 4.9e-66 216.0 In-house 101-307 (317) alignment 
Range on Protein: 71-278
Range on HMM: 101-307/317.0
TTYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQAYGFYDECLQKYGNsNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTV
  |.|.||.|||| .|.|  . |..|| .|||...|||||||.| . . |||| |. ..| . . ..    .|  | ..|.....|||.|||.| ..  .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa.alyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQIRTIERCQEIPHEGAFCDLVWSDPDE-IETWLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASI
.|. ...|  .||  |  .||.|.|||. ....  |.|||| .||.| | ||..  .|.|. ||||.|..| .. |..  | |..|||.|| .  |.|..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyef.fadrklvtifsapsycGqldniaav

LEINEKLEQ
|....||. 
lsvdkklki
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 72-278 4.4e-51 167.0 In-house 121-326 (339) alignment 
Range on Protein: 72-278
Range on HMM: 121-326/339.0
TYIFMGDFVDRGHYSLETFTRLLTLKAKYPDRMVLLRGNHETRQITQAYGFYDECLQKYgNSNAWKYCTEVFDLLSVAALIDDQILCVHGGLSPDVPTVD
 |.|.||.|||| .|.|    | .||  ||||. |||||||.| .  .|||| |   .| ... ..   ..|... ..|.|.. |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QIRTIERCQEIPHEGAFCDLVWSDPDEIET-WLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYhFENNALATVWSAPNYCYRCGNVASIL
|.  ..|  |||  | . || |.|||  |  .  | ||| ..||   .  | .   |... | ||.|..| .. |.   | |..|||||| .  | |...
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyef.fdgrrlvtifsapnycgqndntaavf

EINEKLEQ
 |..||. 
sidkklki
subfamily_PPP7C_pd Subfamily PPP7C 189-286 1.6e-12 39.9 In-house 238-335 (383) alignment 
Range on Protein: 189-286
Range on HMM: 238-335/383.0
CDLVWSDPDEIET-WLVSPRGAGYLFGSKVVSEFCNINSLKLICRAHQLVQEGLQYHFENnALATVWSAPNYCYRCGNVASILEINEKLEQHPIFFEAV
 |..|||| . |  .  . ||.|  ||. | ... .  .|||. |.|.  .|| ..  ..  . |..|| ||     |  . . ....|. . . . | 
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdk.kvltifsasnyyeeGsnrGayvklgkdltprivqyqas