Gene PPPLV in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPPLV
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP107_AA protein Get Run
MbreP107_AA_198-511 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPPLV_pd Subfamily PPPLV 199-511 4.9e-168 550.8 In-house 1-290 (290) alignment 
Range on Protein: 199-511
Range on HMM: 1-290/290.0
LLPSLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFASQFWRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELES
||.||||||...|||.|.||||.||||||||||||||||.||....||||||..|..|||||||||||..|||||||||||||||||||.||||||||||
lllslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnheles

VCGNIEYYGAGSFRHqlhsllvaagrGDQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMTQAPTSPAQNILERIKamqrplcedDDIDGAPdc
|...|||.|.|||..           ||.||..|.||.|.|..|||||.|||.|||.||||||||||||..|..|.||||.|         |||||||  
vqesieykgegsfkf...........gdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk.........ddidgap..

MAMDMLWSDPASGRDLPFMGHQGLPAGFAPNmDRGGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLSNSAALIVISK
.|.|.||||||..|||...|...|..||..| ||.|...||.|.|..||.|.....|.||||....||||.|...|..||||||||||.||.||||...|
laldilwsdpaedrdlslrgelvlneGfvdn.drrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalilvdk

SSMDIVTTGPTDE
....|.|||||||
kklriittgptde
0045823 Metallo-dependent phosphatases 199-511 1.3e-70 231.4 In-house 47-326 (473) alignment 
Range on Protein: 199-511
Range on HMM: 47-326/473.0
LLPSLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFASQFWRTGVDicpsNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELES
 | .|.| |.  |.    ||||. ...|.||.||.. ||.    .. . ..|    .|.||||.|||||.|.| . .|||||..||..|.||||||||  
dllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfpped....rlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHElrl

VCGNIEyygagsFRHQLHSLLvAAGrgdqlesTWGAFMNCFNWLPLAATIDRTVFCCHAGIPraimtqaptsPAQNILERIKAMQRPLCEDDdidgapDC
..|         |.....  . ..         . .|......||||| |. .....|.|..          |  . |. |....|||  .|      |.
lnglyg......fgdetleky.ged.......lyeeflewlrslPlaaviggkilfvHGGls..........pdlplldqireierpleipd......dg

MAMDMLWSDPasgrdLPFMGHQGLPAGFAPNMDRGgDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGAR------VVTVFSSSRYCG-LSNSA
 ..|.|||||      . .|.  |.  | .|  ||  ...||. ||. |.|. |.|.. |.|.. . |.... . .      ..||||.. |||   | |
llldllwsdP.....weddgdgllrlrffgnsprg.agylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnla

ALIVISKSSMDIVTTGPTDE
|..||..  . ...  |.. 
Avlvidedlisfiqfdpsph
0053225 Metallo-dependent phosphatases 199-498 1.6e-58 191.6 In-house 26-279 (293) alignment 
Range on Protein: 199-498
Range on HMM: 26-279/293.0
LLPSLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFASQFWRTgvdiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELES
 |  |.. |.. |     ||||. ..||.||.|||. ||.    ..        ...|.||||.|||||.|.| . .|||||.|||..|.||||||||  
elllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfp....pedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElml

VCGNIEyygagSFRH-----QlhsllvaagrgdqLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMtqaptspaqnILERIKAMQRPLCEDddid
..|  .      ...                    .. | ........||||| |. .....|.|..  .            |. |. ..||| ..    
lnglyg.....fgdetlrkyg.............aaelwdelldwlrslplaaliggkilfvHgGlspdls..........lldqireinrplrip....

gaPDCMAMDMLWSDPasgrdlpfmghqGLPAGFAPNMDRGGdsCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCG-LSNSAA
   . . .|.|||||             |  |..|.... |  .|||. ||. |.|. | |.. |.||. . |...  . ..|||||...|.| |.| .|
..legllldllwsdp............dlwsgwlpsyrglg..vvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlga

LIVISK
......
vlalde
0049330 Metallo-dependent phosphatases 200-499 4.9e-62 202.9 In-house 35-288 (309) alignment 
Range on Protein: 200-499
Range on HMM: 35-288/309.0
LPSLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFASQFWRTGVdicpSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESV
|  |.. |.. |     ||||. ...| ||.||.. ||.    ..   ..     .|.||||.|||||.|.| . .|||||.|||..|.||||||||  .
llllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppe....drlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrll

CGNIEyygagsFRHQLHSL---LvaagrgdqlesTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAImtqaptspaqNILERIKAMQRPLCEDDDiDgap
.|  .      |.....                  | .|......||||| |. ...|.|.|..  .          . |. |....|||  ..| .   
nglyg......fgdetlrkygae...........lweefldwlrslplaaviggkilcvHgGlspdl..........llldqirelerpleipld.g...

dcMAMDMLWSDPASGRDLpfmghqglpagFAPNMdRGGDsCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGL-SNSAALIV
  . .|.|||||   |.            ||||  || . .|||. ||. |.|. | |.. |.|.. . |...  . ...||||...|||  .| .|...
..llcdllwsdplpireg...........fapnp.rglg.vvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavle

ISKS
|...
ided
PPP_3 200-500 1.1e-55 181.6 In-house 7-262 (271) alignment 
Range on Protein: 200-500
Range on HMM: 7-262/271.0
LPSLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFAsqfwRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESV
| .|.. . . |   ..|.|...|  |.||.|| . ||  .     ..| ..  .. |||||||||| .|.| . .|||||..||..|.||||||| ...
lkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelf....knggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

CgniEYYGagsFRHQLHsllvaagRGDQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMTQAPTSPAQNILERikAMQRPLCEDDdidgapdcm
    ..||   |.. .        .  . .... .....|..||||| ||..|...| |. ..| .   ..  ..  |    .. .|...          
n...kvYg...Fkkevl.......kkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkiev..peegklldll.........

amdmlwsdpasgrdlpfMGHQGLPAGFAPNMDRGGdSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGL-SNSAALIVISK
                 . ..    ..  | .||  ...||. ... |....  ....|||.  ..| ....  .|||||| . ||.  || .|.. ...
.................lssdpekeeglenskrGa.gllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailklee

SS
. 
al
subfamily_PPP1C_pd Subfamily PPP1C 201-500 3.7e-59 193.2 In-house 16-269 (282) alignment 
Range on Protein: 201-500
Range on HMM: 16-269/282.0
PSLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFasqFWRTGVDiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVC
 .|.. | . | .. .||||| |  ..||.||.| ||  .   | ..|.    || |||||||||| .|.| |. |||.|. ||....|||||||  |. 
eallkkareillsqpilleleaPvkivgdihGqyadllrl...fetsgaP.pesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasin

GNIEYYGAGSFRHQLHsllvaagrgdqlesTWGAFMNCFNWLPLAATIDRTVFCCHAGipraimtqapTSPAQNILERIKAMQRPLCEDDDidgapdCMA
    .|     |.. .               | .|...||.||||| .|  ..|.| |           ||  . || |. .||||  ...       ..
riyGfydeckrrysik..............lWktftdvfnclPlaalvdekilcvhGG..........lspelksleqirkiqrPlevpek......gll

MDMLWSDPASGrdlpFmghqglpAGFAPNmDRGGdSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCG-LSNSAALIVISKS
.|.||||| .              |.. | |||  | .||. .|..|....  |...||||  ..| .. .  ..|||||.. ||| . |..|.. ....
cdllWsdpdke....v.......lgwsen.drGv.sftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdee

S
 
l
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 201-496 3.3e-40 131.2 In-house 30-280 (299) alignment 
Range on Protein: 201-496
Range on HMM: 30-280/299.0
PSLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFasqFWRTGVDiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVC
 .||.|| . .| . .|||.|.|  | ||.||.| ||  .   | ..|     .| ||||||||||   .|||. ||. |. || . ..||||||  .. 
qtlcavaksvfasqaslleveapiivcgdihgqysdllri...fdkagfp.pdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpain

GNIEYYGAGSFRHQLHSLlvaagrgdqlestWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRPLcedddiDGAPDCMA
    .|     |..   |             | .| ..|...||.  |   ..| | |.          ||  . |.... ..||       |     . 
rvygfyeecnkrykstrl.............wsifqdafaampltgligsrilcmhggl..........spklqtldqlrdltrpq......dppnpslg

MDMLWSDPASgrdlPFmghqglpAGFAPNMdRgGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCG-LSNSAALIVI
.|.||.||                .. .|. | | | |||.  |.  ... . |.. ||||  . |  . .  ..||.||.  ||| . ||||.. .
idllwadpdq....sv.......kdwlanv.r.gvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkv
subfamily_PPP6C_pd Subfamily PPP6C 201-498 1.3e-35 115.9 In-house 21-272 (290) alignment 
Range on Protein: 201-498
Range on HMM: 21-272/290.0
PSLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQyfasQFWRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVC
  |||. .  |  .  .  ..||  | ||.||.. ||.    ...||| ..  .. .||||.|||| .|.| ...||.||. ||... |||||||   ..
kklcdlvldllleesnvqpvsspvtvcgdihgqfydle....elfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqit

GNIEYYGAGSFRHqlhsllvaaGRGdqleSTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRplCEDDDIDGApdcmA
    .|     ..         |..    ..|  ... |. |..|| ||  |.| | |.          ||  ..|..|. ..|  ...   .||     
qvygfydeclnky.........gna....nawkyctkvfdlltiaaiideqvlcvhGgl..........spdvktldqirvier..aqeiphkga....f

MDMLWSDPasgRDLPFMghqglpagfApnMDRGGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLS-NSAALIVISK
 |..||||    |.            |  .   |   .||.  .| |..    ... ||||  ..|..|.   ..|||.|.  ||    | |... ...
cdlvwsdp...edvetw.........a..vsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaled
PP2Ac_SM00156 202-500 3.9e-60 196.2 In-house 8-260 (271) alignment 
Range on Protein: 202-500
Range on HMM: 8-260/271.0
SLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFAsqfWRTGvDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCg
.|.. . . | ....|.|...| .| ||.||.. || ..     ..|   . .. .||||||||||.|.| | .|.|||.|||.||.||||||| .||  
elleevkeilkqeknlvevsapvtvvGdihGqlddllrll...elag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn.

niEYYGagsFRHQLHSLLvaagrgdqLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRaimtqaptspAQNILERIKAMQRplceddDIDGAPDCMAM
  ..||   |.....            ....  |...|..||||| .|....| | |..             . |..|. ..|        . . .....
..kiyg...feeevkrky........gkeiyekfeeafsllPlaalvdskilcmhGGlsp..........eleslddirklkr......vkekpeeglli

DMLWSDPasgrdlpfmghQGLPAGFAPNMdRGGdSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCG-LSNSAALIVISKSS
|.|||||           .    ||.|.. ||  |.||||.||| |.|.   .   |||.  |.| .. .  ..||.||...||.  ||.|| . ..|..
dllwsdp...........eqkekgfqpsk.rgl.svvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 202-498 4.1e-50 163.5 In-house 31-282 (298) alignment 
Range on Protein: 202-498
Range on HMM: 31-282/298.0
SLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFasqFWRTGVDiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCG
.|...|.  ... ..|.|...|  | ||.||.| ||  .   | ..|     .| |||||||||| ...|.|  ||| || ||....||||||| |..  
klielakkifkkqkslvevdapikvcGdihGqysdllrl...fdkagfp.pdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceainr

NIEYYGAGSFRHQLHSllvaagrgdqlesTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMtqaptspaqnILERIKAMQRPLcedddiDGAPDCMAM
.  .|   . |..  .              . .| . ||.|||.| |   ..| | |. . .            |.......||       |.  ...|.
vyGfyeeckrrykslr.............lyaefqdvfnalpltaliggrilcmhGGlskklk..........sldqlrelkrpf......dskeeslai

DMLWSDPASGRdlpfmghqglpAGFAPNMdRgGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCG-LSNSAALIVISK
|.||.||..              |.|.|  | | |.|||| .|| ....   |.. ||||    |  . .. ..||.||. .||| . ||||.. ...
dllwadpenav...........kgwaens.r.GvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvde
PPP_1 202-491 5.7e-50 163.0 In-house 8-258 (264) alignment 
Range on Protein: 202-491
Range on HMM: 8-258/264.0
SLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLqyFasQFWRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCg
.|.. . . |  .|.|||....  | ||.||.. ||  .  .. ..| .   .| |||||||||| .||| . .|||||. ||....||||||| ..|  
elkkklkellnkeenllevseeitvcGDiHGqfdDL..l..klfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt.

niEYYGagsFRHQLHsllvaagRGDQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMTQAPTSPAQNILEriKAMQRPLCEDDDIDgapdcmam
  ..||   |.. .        .  . .. . .....|..||||| ||  ....| |.   . ..      ..  |   ... .||.. . |        
..kvyg...FkkEvl.......kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrkte..vpeegklcdllekd........

dmlwsdpasgrDLPFMGHQGLPAGFAPNMDRGGdSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLSNSA
               . ..   ... .| .||. ...||. ... |..... ....|||.  ..| .. .  .|||.||.| |.   . .
...........vdillsddkeqeeavansiRGa.gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnr
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 202-497 2.2e-47 154.7 In-house 13-287 (302) alignment 
Range on Protein: 202-497
Range on HMM: 13-287/302.0
SLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFAS-Q------FWRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNH
.|..  . .|  .. | |. .|  ..||.||...||      .        .. .  . .  .|||||||||..|.| |. ..|||||||..  ||||||
llieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnh

ELESVcgniEYygAGSFRHQLHSLLvaaGRGDqLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRPLCEdddIdg
| ...    ..  | .||..|.  |   |. |     |  | ..| ..|||| . . ..| | ||          ||  . || || ..||| |   .  
etkai....nf..aygfreelenrl...gkkd.gkeiwekfnevfsfmplaalvgekilcvhggi..........spklesledikkikrplke...v..

APDCMAMDMLWSDPASGRDLPFMGHQglPAgFAPNMDRGgDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLS-NSAAL
..| .| |.|..||. .  |  . ..  |. .| |. ||  | || ||||. . |. . ....||||   .| .. .  ...|.||..||   | |. | 
tedslaqdllfadpldvqllaavsek..Pk.yaknivrg.lsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGav

IVIS
. . 
lkvd
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 202-497 3.3e-47 154.1 In-house 14-288 (302) alignment 
Range on Protein: 202-497
Range on HMM: 14-288/302.0
SLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFAS-Q------FWRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNH
.|..  . .|  .. | |. .|  ..||.||...||      .        .. .  . .  .|||||||||..|.| |. ..|||||||..  ||||||
llieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgnh

ELESVcgniEYygAGSFRHQLHSLLvaaGRGDqLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRPLCEdddIdg
| ...    ..  | .||..|.. |   |. |     |  | ..| ..|||| . . ..| | ||          ||  . || || ..||| |   .  
etkai....nf..aygfreelenrl...gkkd.gkeiwekfnevfsfmplaalvgekilcvhggi..........spklesledikkikrplke...v..

APDCMAMDMLWSDPASGRDLPFMGHQglPAgFAPNMDRGgDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLS-NSAAL
..| .| |.|..||. .  |  . ..  |. .| |. ||  | || ||||. . |. . ....||||   .| .. .  ...|.||..||   | |. | 
tedslaqdllfadpldvqllaavsek..Pk.yaknivrg.lsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGav

IVIS
. . 
lkvd
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 202-498 3.3e-41 134.6 In-house 15-271 (284) alignment 
Range on Protein: 202-498
Range on HMM: 15-271/284.0
SLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYF-ASQFWR-TGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESV
 ||  |  ..  ... ||.|.|  . ||.||.. ||. .   . |  .  .   .. |||||||||||.|.|.|. |.|.|.|.| ||.|||||||   |
elcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpv

CGNIEYYGAGSFRHqlhSllvaagrgdqlESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMTqaptspaqniLERIKAMQRPLcEDDDIdgapdCM
  .  .|     |.   |           |. . ||  .|| .||.| ... ..| | ||.  ..           |.......||. .  ||      .
nmqygfyleckkry...s...........ealyeafqlafnamplcavvskkiicmhggisedlld..........lkqldklerpi.dipdi.....gv

AMDMLWSDPASGRDlpfmGHQglpagfapNMDRGgDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLSN-SAALIVISK
  |. |.|| .  .    |..        . .||    |||..||| |.|.   |...||||    |  . .  ..||.||.  |||  .  ||.. ...
iadltwadpeaeve....gyk........esprg.agkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvde
subfamily_PPP4C_pd Subfamily PPP4C 202-496 1.1e-38 126.1 In-house 23-271 (288) alignment 
Range on Protein: 202-496
Range on HMM: 23-271/288.0
SLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQyfasQFWRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCG
.||  |   |  .  . ...||  | ||.||.. ||.    .... | |.   | |||||.|||| .||| .  |||||| || ...|.|||||  ..  
alcakareilveesnvqrvdspvtvcgdihgqfydll....elfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitq

NIEYYGAgsfrhqlhsLLVAAGRgdqlESTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRplCEDDDIDGapdcMAM
   .|            |   |      . |   .. |..|.||| ||  .|| | |.          ||  . |. |....|  ...   .|    .  
vygfyde.........clrkygs....anvwryctevfdylslaaiidgkifcvhggl..........spsistldeirsidr..kqevpheg....plc

DMLWSDPASGRdlpfmGHqglpaGFAPnmdRgGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGL-SNSAALIVI
|.|||||   .     |      . .|   | |   .||. .|. |... . ... ||||   .| ...   .|.||.|.  ||    | ||.. .
dllwsdpedae.....gw.....avsp...r.gagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaailel
subfamily_PPP2C_pd Subfamily PPP2C 202-497 3.5e-38 124.4 In-house 24-273 (290) alignment 
Range on Protein: 202-497
Range on HMM: 24-273/290.0
SLCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQyfasQFWRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCG
.||. |   |. .. . |...|  | ||.||.. ||     .... | .   .| |||||||||| .||| ...| |||| |.... .||||||   .  
elcekakeilskesnvqevkcpvtvcgdvhgqfhdll....elfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitq

NIEYYGAgSFRHQlhsllvaaGRgdqlESTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRplcedddIDGAPDC-MA
   .|.   .|.         |      . |  | . |..|||.| .|. .|| | |.          ||. . |..|.|..|       ..  |.    
vygfyde.clrky........gn....anvwkyftdlfdylpltalvdeqifclhggl..........spsidtldkiraldr.......lqevphegpl

MDMLWSDPAsGRdlpfmghqglpAGFApnMDRGGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGL-SNSAALIVIS
 |.|||||   |           .|..  . . |    ||.   ..| |. |  .. ||||   .| ..    .|||.||.  ||    | ||.. . 
cdllwsdpd.dr...........ggwg..isprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaaileld
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 203-494 2.8e-40 131.5 In-house 31-279 (297) alignment 
Range on Protein: 203-494
Range on HMM: 31-279/297.0
LCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFasqFWRTGVDiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGN
| |.|.  . |.. ..|...|  | ||.||.. ||  .   | | |     .| ||||||||||  |.| |  ||| || .|....||||||| | |   
lldlaldvfkaqksmvevnapikvcgdihgqfpdllrl...fhrggwp.ptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkv

IEYYGAGSFRHQlhSLlvaagrgdqleSTWGAFMNCFNWLPLAATIDRTVFCCHAGIPrAIMTQAPTspaqniLERIKAMQRPlcedddIDGApDCMAMD
  .|     |.|  |.             . || . ||||||.  |   ..| | |.   ..|.  |      |. .. ..|.       .|  . .  |
ygfyeecqkryq..sv...........rmyaafqdvfnwlpltgliatkilcmhggls.plltkeft......ldtlrkiers......tegk.erlvad

MLWSDPASGRdlpfmghqglpAGFAPNmDRgGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGL-SNSAALI
.||.|| ||            .||  | .| |  | ||  ||     .   |.. ||||  . |  . .| ..||.||. .|||   | ||..
llwadpisgl...........sgfmen.qr.gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafm
subfamily_PPZ_pd Subfamily PPZ 203-498 4.1e-34 111.5 In-house 33-282 (300) alignment 
Range on Protein: 203-498
Range on HMM: 33-282/300.0
LCDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFasqFWRTGVDiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGN
.|  |   . |.  ||||  .  ..||.||.| ||  .   | . |.    .| |||||||||| .|.| |  ||. |. || ...|||||||   |   
icikarelflaqpallelspsvkivgdvhgqyadllrl...ftkcgfp.psanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrv

IEYYGAGSFRHQLhsllvaagrgdqleSTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRPLceddDIdgaPD-CMAM
  .|     | ..                | .|.. || ||||| .   .|| | |.          ||  | .. |. . ||     |.   ||  .  
ygfydeckrrcni..............kiwktfvdtfntlplaaivagkifcvhggl..........spvlnsmdeirhvvrpt....dv...pdfglin

DMLWSDPASGrdlpfmghqglPAGFAPNmDRGGdSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCG-LSNSAALIVISK
|.|||||.             .  .  | .||  | .. . |.. |... | |.. |||   . |  .     .|||||.  ||| . |  |.. .|.
dllwsdptds...........snewedn.ergv.sycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvse
subfamily_PPG1_pd Subfamily PPG1 204-495 1.8e-37 122.2 In-house 23-280 (300) alignment 
Range on Protein: 204-495
Range on HMM: 23-280/300.0
CDVAMRQLAADEVLLELESPTYVLGDLHGNYRDLQyfasQFWRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGNI
.|     |  .  . |..||  |.||.||.. |.     . .. | ..  .| |||||||||| .||| |. |..||. |||.. |||||||   .    
tdklkellvkesnvieirspvtvvgdvhgqfydvl....eifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvy

EYYGAGSFRHqlhsllvaAgrGDqlESTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRplCEDDDIDGApdcmAMDM
 .|.    ..        .  |.     |  . . |..| ||| ||  ..| | |.          ||.   ...|| ..|   ..   .||      |.
gfyteclrky........g..gn..srvwkylteifdylvlaaiideeiycvhggl..........spsvlsidqikvldr..frevpnega....ladl

LWSDPASGrDLPFMGHQGLPAGFAPNMDRgGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLSNSAALIV
|||||    . | . |      .  . .| |    .|.  |. |...   . ..||||   .| .    ... ||.|.  ||      | |.
lwsdpeen.nnptldhpdregqhfvvsqr.gagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasil
subfamily_PPP3C_pd Subfamily PPP3C 206-504 3.5e-45 147.6 In-house 52-317 (452) alignment 
Range on Protein: 206-504
Range on HMM: 52-317/452.0
VAMRQLAADEVLLELESPTYVLGDLHGNYRDLQYFASqfwrTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCgniEY
 | . |  .. |||.|.|  |.||.|| . ||  . .     | |   .. |||||||||| .|.| . ||.|||. |||...|||||||   .    ||
eaakllkkektlleveaPitviGdihGqfydllklfe....vgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlt...ey

ygagsF--RHQLHSllvaagrgDQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRplCEDDDIDGaPDCmamDM
     |  ......           |... |.|..|. ||||| ...  .|.| |.          ||  . |. || ..|   .. .  | | |   |.
.....ftfkeecki........kyseevydacmesfdslPlaallnqqflcvhGGl..........speikslddikkldr..fkeppasG.plc...dl

LWSDPAsgrdLPFmGHQGLPAGFAPNMDRGGdSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTG------ARVVTVFSSSRYCGL-SNSAALIVI
|||||.      . |..     | ||  ||  |.... .||  |....    ..|||.  |.| | .          ..|.||.. |..  .| ||.. .
lWsdPl....edy.geekteekfvpnsvrGc.syfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlky

SKSSMDIV
 . .|.| 
ennvmnir
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 208-498 5.8e-42 136.7 In-house 19-263 (280) alignment 
Range on Protein: 208-498
Range on HMM: 19-263/280.0
MRQLAADEVLLELESPTYVLGDLHGNYRDLQYFASQFwrtGVDiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGNIEYYG
 . |.|.. ..|...|  | |||||.| ||  . ..    .     .| |||||||||| . .|.|  ||| || || . ..||||||  |.  .  .. 
kkiltaqatmvevdapvavcgdlhgqytdllrlfarv...sfp.pdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfkd

AGSFRhqlhsllvaagrgdQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMTqaptspaqniLERIKAMQRPLCEDDdidgapDCMAMDMLWSD
    |                .. .  | . .. |||.| .   ..| | |. . ...          |. .. ..||.  .|      .|.|||.||.|
evkrr..............yslalynefqelldslplvalvsgrilcmhgglsqklvs..........lddlaelrrpfdsed......eclamdllwad

PASGRdlpfmghqglpAGFAPNmDRgGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCG-LSNSAALIVISK
|..             .|.| |  | | | .||.  || ....   |.. | ||  . |  . .. ..|||||. .|.| ..||||......
penkv...........tgwaen.sr.gvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivde
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 210-508 1.4e-50 164.8 In-house 25-281 (287) alignment 
Range on Protein: 210-508
Range on HMM: 25-281/287.0
QLAADEVLLELESPTYVLGDLHGNYRDLQYFASQfwrTGVDiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGNIEYYGAG
 |   ..|||.|.|  ..||.||.. ||  .  .    |      . ||||||||||..|.|.. .|..||..|| ||.|||||||.. .  .  ..   
ileplpalleveapitivGdihGqlddllrifna...vGaa.pkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkeel

SFRHQlhsllvaagrgdqlESTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRPlceddDIDG-APDCMAMDMLWSDP
  ..|              |. .  | . |. ||| |.... ..| | ||          ||  . |. .||...|       ..   . . .|.||.||
krkrq..............erlykqfndvfselplcarvskrilcmhGGi..........spklksldslkalkkp.....ttplacdeglqvdllwadp

ASGRDlpfmghqglpaGFAPNMDRGgDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCG-LSNSAALIVISKS-SMDIVTT
    .           .|..|  |.  | |||.  |  ..|. . |...|||.  ..|  .    |.|||||...|.|  .| .|..|.|||  . .|. 
ekdak...........tfelnkira.isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvl

GP
 |
kp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 211-499 1.4e-37 122.6 In-house 19-263 (284) alignment 
Range on Protein: 211-499
Range on HMM: 19-263/284.0
LAADEVLLELESPTYVLGDLHGNYRDLQYFasqFWRTGVDIcPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGNIEYYGAGS
.  . .|.| .||  . ||.||.. ||  .   | . |.    .| |||||||||| | .| |  |.| ||..| ....||||||   .     .|    
fnkqpmlievnspinicgdihgqfsdllrl...fdkngfph.ranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfyeecq

frhqlhsllvaagRGDQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAImtqaptspaQNIlERIKAMQRPLcedDdiDGAPDCMAMDMLWSDPAS
             |  .  | . .|   |  .||.| . . ..| | |. . .         ||.  ...|..||.   |  .  |. .|.|.|||||. 
.............rrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskml.........qnv.sqlraikrpf...d..npepntlaidilwsdptn

grdlpfmgHQglpAGFAPNMdRgGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGL-SNSAALIVISKS
         |    |. ||  | | | |||  |.. .. .   |...||||  . |  . .  |.||.||.  |||   |.||.. . | 
........fq...kgwnpns.r.gvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnkn
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 212-499 2.6e-27 88.8 In-house 37-280 (307) alignment 
Range on Protein: 212-499
Range on HMM: 37-280/307.0
AADEVLLELESPTYVLGDLHGNYRDLQYFASQFWRTgvdiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGNIEYYgagsf
...  |.... |  |.|||||.. ||  .   . |       .  .| |||||||  |.| |  |.. |. || .. |||||||.  |  .  .|     
ssekalvdidppcvvvgdlhgqfndlinmfillgrp....petvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfy.....

RHQLHSLlVAAGrgdqlESTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRPLCEddDIDGapdcMAMDMLWSDPAsg
   . |.   .|     |  |  |  ||| ||..| |   ..| | |.          |||   |. ..   .|. .   . |    .  ||||.||   
eecvtsi.pkcg.....eeiwalfqrcfnnlpisaliatkilcmhggl..........spaltcldelrnhpkpirn..pfrg....ivndmlwadpd..

rdlpfmghqglPAGFAPNMDRGGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLSNSAALIVISKS
           |. |  .    |    ||   .    |. | ....||||    |    .| ...|.||.  || . . |  ..    
...........psvfewkassrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvde
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 213-500 3.2e-41 134.2 In-house 34-279 (290) alignment 
Range on Protein: 213-500
Range on HMM: 34-279/290.0
ADEVLLELESPTYVLGDLHGNYRDLQYFASQFWRTgvdiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVcgNiEYYGagsFR
   .|||.|.|  ..||.||.  .|  .  .  .        . ||||||||||..|.|.  .|. .|..|. ||.|||||||   |  |   ||   |.
plpalleveapivivgdihgqldallryfdavgyp....pkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkv..n.rlyg...fk

HQLhsllvAAGRGDQLestWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRPLCEDDDIdgapDCMAMDMLWSDPASGR
 .|     |  || .|   |  . . |. |.| |...| ..| | ||          |.  .  | .||...|  . .      . . .|.||.||.  .
eel.....arkrgsrl...wkqyqdvfaelslcarvgrkilcmhggi..........sqkiesweslkalkkprvpltcd....eglqvdllwadptrdk

DlpfmghqglpAGFAPNMDRGgDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGL-SNSAALIVISKSS
|            .| |  |.  | |||. ..  ..|. . ....|||.  ..|  ..   ..|||||.  |.|  .|  |.. .|.| 
d..........dtialnkqra.isvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvsesl
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 213-503 2e-40 131.8 In-house 26-269 (281) alignment 
Range on Protein: 213-503
Range on HMM: 26-269/281.0
ADEVLLELESPTYVLGDLHGNYRDLQYFASQFWRTgvdiCPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGNIEYYGAGSFr
 .. | |...|. |.||||....||.       |         |.||||||||||.|.|..  |..||. |. ...|||||||. ||     .|    . 
eekaLveidkPivvvGdlhaqfndlkrlfellgrv....peevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygfyvecvt.

hqlhsllvaagrgDQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRPLCEDDdidgapDCMAMDMLWSDPAsgr
                |  |  | .||| ||..| |.. | | | |.          ||.   |.... . .|. . |        . .|.||.||    
.............kyGeelwalfqrcfnrlpisaliakrvlcmhGGl..........sPeltaldelrnrpkpirnld......rGlviDllwadpd...

dlpfmghqglPAGFAPNMDRGGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLSNSAALIVISKSSMDI
          . ..       | | .||.. |.   |. . ... ||||    |..  .| ...||||   ||   . || ..  . ...|
..........nkveewkassrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgi
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 215-502 1.4e-34 112.8 In-house 26-266 (280) alignment 
Range on Protein: 215-502
Range on HMM: 26-266/280.0
EVLLELESPTYVLGDLHGNYRDLQYFASQFWRtgvdICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGNIEYYGAGSFRHQ
  | | |.|  |.||.| .|.|.. .     |    .   .|.||||||||||. .|..  |..||. |  ..||||||||  ||     .|    ... 
snlceaeapikvigdihaqyqdmnrlfdligr....vpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqykyg

LhsllvaagrGdqlesTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRPlCEDDDidgapDCMAMDMLWSDPASGRDL
.         |      |  | .||| .|... | . |.| |.|.          ||    |. |. . || ||  |       . .|.|||||.   . 
v.........g.....lwwdfqscfnrmpmsgliskrvlcmhggl..........spelinldtirniprp.cepld.....rgllidllwsdptnkgeg

PFMGHQGLpagfapnmdrggdSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLSNSAALIVISKSSMD
 |   .|.             | .||.. |.   |    |...||||  . |    .| |..||||   ||     || .|. .. ..
wfhsirgi.............symfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlq
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 217-499 1.3e-38 126.1 In-house 2-245 (263) alignment 
Range on Protein: 217-499
Range on HMM: 2-245/263.0
LLELESPTYVLGDLHGNYRDLQYFasqFWRTGVdICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGNIEYYGAGSFRHQlh
||||..|  . || ||.| ||      |   |     .. |||||||||| ||.|.|  |..||.  | |..||||||||...  |  ..     | |  
llelqapinicgdthgqyndllri...fnacga.atktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfq..

sllvaagRGDQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIpraimtqaptSPAQNILERIKAMQRPLCEDDdidgaPDCMAMDMLWSDPASgrDLpf
       | .  || .  | . |...||.| . . ..| | ||          ||  . |. |.|.  ||            .| |.||.||    |   
.......reevyesvynhfnqvfsymplcaivskrilcmhggi..........sphlkslddiraiplpletak.....thplacdllwadpek..da..

mghqglpAGFAPNMDRGgDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYC-GLSNSAALIVISKS
        || ||  |   | |||.  |  . |.   |...||||  . |  . .  |..||||.|||   | | ||..|. | 
.......kgfepnkira.isnvfgkkevddlckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkm
subfamily_PPP5C_pd Subfamily PPP5C 222-500 2.1e-33 108.7 In-house 65-298 (322) alignment 
Range on Protein: 222-500
Range on HMM: 65-298/322.0
SPTYVLGDLHGNYRDLQYFasqFWRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVcgNiEYYGagsFRHQlhsllVA
.   | ||.||.. ||      |   |.       || ||.|||| .|||.|  ||..|.||| ...| ||||| ...  | . ||   |. .     | 
kkltvcGdihgqfydllni...felnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnm..n.klyG...fege.....vk

AGRGdqlESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPraimtqaptSPAQNILERIKAMQRPLCEDDdidgapDCMAMDMLWSDPASgrdlpfmgHQg
|      |     | . |||||||  |.  |. .| |..         |  .  |. .. ..|   . .      . . ...||||| .        .. 
akyt...ekvadlftevfnwlPlahvinekvlvvhGGlf.........sedgvtlddlrkidrnaqppe......egllvellwsdpqe........an.

lpaGFAPNmdRGGDSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCG-LSNSAALIVISKSS
   | .|   . | .. ||    | |.|. . . ..|.|.  ..|.. .   ...||||.  ||   .| .|.| . .. 
...Grsps..krGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd
Metallophos Calcineurin-like phosphoesterase 224-462 4.5e-29 95.1 Pfam-A 3-198 (200) alignment 
Range on Protein: 224-462
Range on HMM: 3-198/200.0
TYVLGDLHGNYRDLQYFASQFWRTGVDICPSNLLFLGDYVDRGPHSVELIAYL--LALKVLYPSKVYLLRGNHELESVCGNIEYYGAGSF----------
  |.|||||.. || ... .. . ...  | ..|||||.||||..| | .|.|  |.||.|.| .|.|||||||  ..      .   .           
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

----------RHQLHSLLVAAGRGDQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMTQAPTspaqnilerikamqrplcedddidgapdcmam
           ..         ...   |.. .. ..|..|||.| .| .....|... .   .  ..                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

dmlwsdpasgrdlpfmghqglpagfapnmdrggDSCVFGEAAVKAFMKQTGCDFMLRAHQP
                                  |. ||. |.  . .. |.|  ||.|. 
.................................gselfgpdalekllekygvdlvlrGHtH
subfamily_YNL217W_pd Subfamily YNL217W 224-298 2.7e-07 23.3 In-house 12-78 (235) alignment 
Range on Protein: 224-298
Range on HMM: 12-78/235.0
TYVLGDLHGNYRDLQYFA-SQFWRTGVDIcpsNLLFLGDYVDRGPHSVELIAYLlalkvlYPSKVYLLRGNHELES
 .| || ||.| .|  .   .    . ..    ....|| ...||.||| . |.        ..|. ..||||   
llvvGdvhgaYDelieLlddkiggkdenv...lvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelv
PPP_4 225-461 2.4e-43 141.5 In-house 2-195 (197) alignment 
Range on Protein: 225-461
Range on HMM: 2-195/197.0
YVLGDLHGNYRDL-QYFAsQfwrTGVDICP-SNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVcgNiEYYGA-GSFRHQlhsllva
.| ||.|| . || ...  .   .|..  . ....|||||||||..|.| . .|||||. ||..|.||||||| .|.  | ..||   .. ..       
tvvGDiHGqlddlllkll.k...ngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEsksl..n.llygfkkevlek.......

agrgdQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMTqapTSPAQNILERIKAmqrplcedddidgA-PDCMAMDM-LWSDPAsgrdlpfmgh
     . .... .....|..||||| ||..|...| |... . .    .  ..| . |.                 .....|. |||||.          
.....hgkeilkklqdvfdllplaalidekvlvvhgglsdeles...ldkierierkies.............pleeekrkdlllwsdpr..........

Q---GlpagFAPNmDRGGDScVFGEAAVKAFMKQTGCDFMLRAHQ
.   |    .|..  ||..  .||. ... |..... ....|.|.
eaqeg....lans.vrGagl.lFgpdvtekfleknnlkliirshe
PPP_5_Dcr2 225-461 1e-42 139.4 In-house 2-197 (199) alignment 
Range on Protein: 225-461
Range on HMM: 2-197/199.0
YVLGDLHGNYRDL-QYFASqfwrTGVDICP-SNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCgniEYYGAGSFRHQ-Lhsllva
.|.||||| . ||  ..      .| |  .  ...|||||||||..|.| . .|||||..||..|.||||||| |..    |.||  .  ..        
tvcGDlHGqlddlllilfk....eggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqln...eiygftkevlsky......

agrgdQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMtQaptspaqniLERIKAMQRPlCEDddidgA-PDCMAMDM-LWSDPAsgrdlpfmgh
     . .. . .. ..|.|||||| ||..|...| |... |  .         .| .....|. .|         .   .|. |||||.          
.....hgkkiykilsdvfdwlPlaalidekvlvvhgglspeik.s.........iellekierk.iei.....peekgekadlllwsdpr..........

qG----LpagFAPNMdRGGDScVFGEAAVKAFMKQTGCDFMLRAHQ
      .   ....  ||..  .||. ... |..... ... |.|.
.daqegc...klnse.RGagl.lfgpdvtekfleknnlkliirshe
PPP_2 226-461 2.1e-41 134.8 In-house 3-196 (198) alignment 
Range on Protein: 226-461
Range on HMM: 3-196/198.0
VLGDLHGNYRDLQYFAsqfwRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCgniEYYGagsFRHQLHsllvaagRG
|.|||||.. ||  .     ..| ..  .. |||||||||| .|.| . .|||||. ||..|.||||||| ..|    ..||   |....        . 
vcGDlHGqldDLlilf....knglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvn...kvyg...Fkkevl.......kk

DQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMTQAPTSPAQNILERikAMQRPLCEDD---DidgapdcmamdmlwsdpasgrdlpfMGHQGL
 . .... .....|..||||| ||..|...| |. ..| .   ..  ..  |    .. .|...    .                         . ..  
kggkkvykklqevfelLplaalidekvlvvHGGlseeiklldqikkeerkies..peegklldlleeek.........................lsdpke

PAGFAPNMDRGGdSCVFGEAAVKAFMKQTGCDFMLRAHQ
  ..  |  ||. ...||. ... .....  ....|||.
keellansarGa.gllfgpdvteelleknklkliiRaHe
subfamily_PPP7C_pd Subfamily PPP7C 226-503 1.7e-31 102.3 In-house 68-328 (383) alignment 
Range on Protein: 226-503
Range on HMM: 68-328/383.0
VLGDLHGNYRDLQYFasqFWRTGVDICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVcgNIEYygaGsFRHQLHSLLVAagrg
| |||||.  ||      ... |.     . .| ||.|||| .|||..  |||| ..|| .||| |||||   .  |. |   | | ....|        
vcGdlhGklddllli...lyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhil..nlry...G.fikeveskykv....

dQLESTWGAFMNCFNWLPLAATIDRTVFCCHAGIPRAIMT----QAPTSPAQNIlerikaMQRPLCEDDDIDGAPD-----------CMAMDMLWSDPAS
 . .     . . | |||||. ||. .. .| ||          .   |  . .      .. || |. . .   .              .|.||||| .
.hgkkilrlledvfawlplatlidekilivhGGisdktdlelldkiersklvsv......lrpplkegeeaekekeessvkvdkeewrqvldilwsdpka

grdlpfmgHqglpAGFAPNMDRGGdSCVFGEAAVKAFMKQTGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCG-LSNSAALIVISKSSMDI
        .     |  ||  |||  . ||    | .... . ....|.|.   .|  .    .|.|.||.| |    ||  | . ..|. .  
........k....eGckpntlrGg.GsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltpr
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 251-498 7.4e-40 130.0 In-house 98-303 (317) alignment 
Range on Protein: 251-498
Range on HMM: 98-303/317.0
ICPSNLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGNIEYYGAGSFRHQlhsllvaagrgdqlESTWGAFMNCFNWLPLAATIDR
 . .. |||||||||||.|.|..  |.|||.||| ||.|||||||  .|  .  .|     |..              .. . || . || |||.| .. 
kgykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrys..............aalyeafqlafnvlplcavvnk

TVFCCHAGIPRAIMTqaptspaqniLERIKAMQRPLcEDDDIdgapdCMAMDMLWSDPASGRDlpfmghqglpaGFAPNmDRgGDSCVFGEAAVKAFMKQ
...| | ||.  ..           |.......||| .  |.      .  |. |.|| .  .           |...   | | . |||..|||.|.|.
kilcmhGGiseelld..........lkqldklkrpl.dipdv.....Gvladltwadpdaevk...........gykes.ar.GagkvfGakavkeflkk

TGCDFMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLS-NSAALIVISK
   |...||||    |  .  . ..||.||.  |||   | ||.. . |
ldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavlsvdk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 255-498 2.3e-33 108.7 In-house 121-322 (339) alignment 
Range on Protein: 255-498
Range on HMM: 121-322/339.0
NLLFLGDYVDRGPHSVELIAYLLALKVLYPSKVYLLRGNHELESVCGNIEYYGAGSFRHQlhsllvaAgrgdQLestWGAFMNCFNWLPLAATIDRTVFC
  ||||||||||| |.|..  | |||. || ..||||||||  ||     .|    .|..       |    ||   . .| | || .|..| |. |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryd.......a....ql...yecfqnmfnvfpfcavinntimc

CHAGIPRAImtqapTSpaqniLERIKAMQRPLcEDDDIdgapdCMAMDMLWSDPASGRdlpfmghqglpAGFAPNMdRgGDSCVFGEAAVKAFMKQTGCD
 | ||   .     ||     ....  ..||| |  |.      .  |. |.||                |. |   | | | |||  |..||.|.   .
mhggisehl.....ts.....fnqfsvfkrpl.eipdv.....gvltdltwadpdpte...........kgykpsa.r.gasfvfgppalraflkkldlq

FMLRAHQPPDKGIRYQTGARVVTVFSSSRYCGLS-NSAALIVISK
...| ||  . |  .  | |.||.||.  |||   |.||.. | |
mvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsidk