Gene MbreHP1-Un-2 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily HP1-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP110_AA protein Get Run
MbreP110_AA_0-201 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051064 Phosphoglycerate mutase-like 1-199 7.2e-18 57.9 In-house 1-197 (241) alignment 
Range on Protein: 1-199
Range on HMM: 1-197/241.0
MATARLFVARHCERAAFARDGHFDlelchqeqagkrrfWND-ALTGEGTRQAVALSRDLPV--GSVRRIVASDWLRCVQTASIVARELGL--TEIELDPA
|.. ||.. || |.   | . . .              | |  || .| .|| || . |     .. ....|..||..||| |.|..|||   ....||.
mmmkrlyLvRHGesewnaegrlqg..............wtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdpr

LGEHEREAWFGETGSR-----PGHLTHSLPELQDFVDATLGPNGQRILLKPHAQPFPDPR--RATDAWEVGEARTAAVAQAILTAGVKTFGHTLLVTHGG
| |    |. | | .      |..| . | .  |.   .|.. ....||  .     ..        ..   || ... . .|.  ..  .. |.|.|||
lrEidfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHgg

VGQRTVEALTG
|    .  |.|
virallayllg
0049178 Phosphoglycerate mutase-like 1-199 1.1e-13 43.9 In-house 1-195 (243) alignment 
Range on Protein: 1-199
Range on HMM: 1-195/243.0
MATARLFVARHCERAAFARDGHFDlelchqeqagkrrFWNDALTGEGTRQAVALSRDLP--VGSVRRIVASDWLRCVQTASIVARELGL--TEIELDPAL
| . ||.. || |    | . . .               .  || .| .|| || . |      . ....|. .|..||| |....|||   ....||.|
mmmtrlyLvRHGetewnaegrlqg.............wtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprL

GEHEREAWFGETGSRP-----GHLTHSLPELQDFVDATLGPNGQRILLKPHAQPFPDPRRATDAWEVGEARTAAVAQAILTAGVKTFGHTLLVTHGGVGQ
 |    |. | | .       ..| . .    |..   | . .... |        |.    . ..   ||  .. . .| . ... .. |.|.||||  
rErdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvir

RTVEALTG
  . .|.|
allalllg
0037864 Phosphoglycerate mutase-like 2-199 9.1e-16 50.4 In-house 2-176 (211) alignment 
Range on Protein: 2-199
Range on HMM: 2-176/211.0
A----TARLFVARHCERAAFARDGHFDlelchqeqagkrrFWNDALTGEGTRQAVALSRDLPV--GSVRRIVASDWLRCVQTASIVARELGL--TEIELD
.    . ||.. ||.|.   | . . .              ..  || .| .|| || . |     .. ....|. ||..||| |....|||   ..|.|
slnllmtrlyLvRHGetewnaegrlqg.............wldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevd

PALGEHEREAWFGetgsrpghlthslpELQDFVDATLGPNGQRILLKPHAQPFPDPrratDAWEVGEARTAAVAQAILTAGVKTFGHTLLVTHGGVGQRT
|.| |    |. |                 . . .. .   ...|  |.  ..|.     . ..   || ... . .|.  .|  .. |.|.||||    
prlrErdfgaleg..............ltleeiaekypeelvawlrdpydfrppgg....EsladvvaRvlpaleellarllkdgenvlvVsHggvlral

VEALTG
.  |.|
layllg
0036887 Phosphoglycerate mutase-like 4-199 8.2e-16 50.7 In-house 2-163 (202) alignment 
Range on Protein: 4-199
Range on HMM: 2-163/202.0
ARLFVARHCERAAFARDGHFDlelchqeqagkrrFWNDALTGEGTRQAVALSRDLPVGSVRRIVASDWLRCVQTASIVARELGlTEIELDPALGEHEREA
 ||.. || |.   . . . .              ..  || .| .|| || . |    . ....|. ||..||| |.|..||  ....||.| |    |
trlyLvRHGetewnvegrlqg.............dldvpLtelGreqaralgerlaglpfdavysSpllRaiqTaeiiaealg.lpvivdprlrEidfga

WFGetgsrpghlthslpELQDFVDATLGPNGQRILLKPHAQPFPDPrratDAWEVGEARTAAVAQAILTAGvkTFGHTLLVTHGGVGQRTVEALTG
. |                 . . .. .   ...|  |.  ..|.     . ..   || .|. ...|       |..|.|.||||    . .|.|
leg..............ltleeiaekypeelaawlrdpydfrppgg....EsladvvaRvlaaleellarl..dggnvlvVsHggvlrallayllg
0043909 Phosphoglycerate mutase-like 4-199 6.7e-15 47.7 In-house 3-200 (249) alignment 
Range on Protein: 4-199
Range on HMM: 3-200/249.0
ARLFVARHCERAAFARdghfdlelchqeqaGKRR-FWNDALTGEGTRQAVALSRDLP--VGSVRRIVASDWLRCVQTASIVARELGL--TEIELDPALGE
 ||.. || |    |               |.    ..  || .| .|| || . |     .. ....|. .|..||| |...||||   ..| ||.| |
krlyLvRHGetewnae..............grfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrE

HEREAWFGETgsrPGHLTHSLPELQDFVDA--------------TLGPNGQRILLKPHAQPFPDPRRATDAWEVGEARTAAVAQAILTAGVKTFGHTLLV
    |. | |      .    ||.. .  .              .| ..  ....  .. |. |.   .. ..   ||  .. . .|   .|  |. |.|
rdfGaleglt...kaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliV

THGGVGQRTVEALTG
.||||    .  |.|
aHggvlrallayllg
0036777 Phosphoglycerate mutase-like 4-199 7e-14 44.5 In-house 3-196 (247) alignment 
Range on Protein: 4-199
Range on HMM: 3-196/247.0
ARLFVARHCERAAFArdghfdlelchqeqA----GkrrfWNDA-LTGEGTRQAVALSRDLPV--GSVRRIVASDWLRCVQTASIVARELG--LTEIELDP
 ||.. || |    |              .    |    | |. || .| .|| || . |      . ....|. ||..||| |....||  | ... ||
krlyLvRHGetewna..............egrfqg....wlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdp

ALGEHEREAWfgeTGSRPGHLTHSLPELQDFVDATLGP----------NGQRILLKPHAQPFPDPRRATDAWEVGEARTAAVAQAILTAGVKTFGHTLLV
.| |    |.   .|     .    ||.. .  .   .          .   . |   |  . |.    . ..   ||  .. . .|   .|  .. |.|
rLrErdyGal...egltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvV

THGGVGQRTVEALTG
.||||    .  |.|
sHggvlrallayllg
0048955 Phosphoglycerate mutase-like 5-199 4.1e-17 55.4 In-house 2-194 (240) alignment 
Range on Protein: 5-199
Range on HMM: 2-194/240.0
RLFVARHCERAAFARDGHFDlelchqeqagkrrfWND-ALTGEGTRQAVALSRDLPV--GSVRRIVASDWLRCVQTASIVARELGL--TEIELDPALGEH
||.. || |.   | . . .              | |  || .| .|| || . |      . ....|..||..||| |.|..|||   ....||.| | 
rlyLvRHGesewnaegrlqg..............wtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrEr

EREAWFGetgsrpghlthslpELQDFVDATLGPNGQRILLKPHAQPFPDPR---------------------RATDAWEVGEARTAAVAQAILTAGVKTF
   |..|               . | . ....   ...|  |.  ..|  .                          ..   || .|. . .|.   |. 
dfgaleg..............ltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpg

GHTLLVTHGGVGQRTVEALTG
.. |.|.||||    .  |.|
knvlvVsHggvirallayllg
His_Phos_1 Histidine phosphatase superfamily (branch 1) 5-189 2.1e-14 46.8 Pfam-A 1-154 (158) alignment 
Range on Protein: 5-189
Range on HMM: 1-154/158.0
RLFVARHCERAafardghfdlelchQEQAGKRRFWNDA-LTGEGTRQAVALSRDLP--VGSVRRIVASDWLRCVQTASIVARELGlTEIELDPALGEHER
||...|| |.               ....|. . |.|. || .| .|| .| . |      . ....|. .|..||| |.. ||. ..|. .|.| |   
rlylvRHGese..............wnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld.ipiikeprLrerdf

EAWfgEtGSRPGHLTHSLPelqdfvdatlgP------NgqrillKPHAQPFPdprRATDAWEVGEaRTAAVAQAILTaGVKTFGHTLLVTHGGV
..|  | | .  ..   .|                  .      ...   .|   ..  . .| | |.|.. ....    .. . .|.|.||||
gew..e.glpkeevkeefp...........eeyekwkr......dkkefrpp...egesladvye.Rvapfleelie.akdkgenvlivsHggv
His_Phos_1 Histidine phosphatase superfamily (branch 1) 5-189 2.1e-14 46.8 In-house 1-154 (158) alignment 
Range on Protein: 5-189
Range on HMM: 1-154/158.0
RLFVARHCERAafardghfdlelchQEQAGKRRFWNDA-LTGEGTRQAVALSRDLP--VGSVRRIVASDWLRCVQTASIVARELGlTEIELDPALGEHER
||...|| |.               ....|. . |.|. || .| .|| .| . |      . ....|. .|..||| |.. ||. ..|. .|.| |   
rlylvRHGese..............wnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld.ipiikeprLrerdf

EAWfgEtGSRPGHLTHSLPelqdfvdatlgP------NgqrillKPHAQPFPdprRATDAWEVGEaRTAAVAQAILTaGVKTFGHTLLVTHGGV
..|  | | .  ..   .|                  .      ...   .|   ..  . .| | |.|.. ....    .. . .|.|.||||
gew..e.glpkeevkeefp...........eeyekwkr......dkkefrpp...egesladvye.Rvapfleelie.akdkgenvlivsHggv
0039931 Phosphoglycerate mutase-like 5-199 4.7e-13 41.6 In-house 1-154 (219) alignment 
Range on Protein: 5-199
Range on HMM: 1-154/219.0
RLFVARHCERAAFArdghfdlelchqeqA----GkrrfwNDALTGEGTRQAVALSRDLPV--GSVRRIVASDWLRCVQTASIVarelGLTeIELDPALGE
||.. || |  . .              .    |     .  || .| .|| || . |     .. ....|. ||..||| |.    ||. .|.||.| |
rlyLvRHGetewnv..............egrlqg.....dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii....glp.veidprLrE

HEREAWFGetgsrpghlthslpELQDFVDATLGPNGQRILLKPHAQPFPDprraTDAWEVGEARTAAVAQAILTagvktFGHTLLVTHGGVGQRTVEALT
    .. |                 . . .. ..  ...|  |   ..|.     . ..   ||  .. ...|       ...|.|.|||| .  .  |.
idfgdleg..............ltleeiaekypeelaawlrdpydyrppg....gEsladvvaRvlpaleella.....genvlvVsHggvirallayll

G
|
g
0035570 Phosphoglycerate mutase-like 5-201 1e-12 40.5 In-house 1-156 (219) alignment 
Range on Protein: 5-201
Range on HMM: 1-156/219.0
RLFVARHCERAAFArdghfdlelchqeqA----GkrrfwNDALTGEGTRQAVALSRDLPV--GSVRRIVASDWLRCVQTASIVarelGLTeIELDPALGE
||.. || |.   .              .    |     .  || .| .|| || . |      . ....|..||..||| |.    ||. .|.||.| |
rlyLvRHGetewnl..............egrlqg.....dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii....glp.veidprLrE

HEREAWFGetgsrpghltHSLPELQdfvdATLGPNGQRILLKPHAQPFPdprrATDAWEVGEARTAAVAQAIltagvKTFGHTLLVTHGGVGQRTVEALT
    .. |          ..|.|..    .. .   ...|  |.  ..|      . ..   ||  .. ...     .  .. |.|.|||| .  .  |.
idfgdleg..........ltldeia....ekypeelaawlrdpydyrpp....ggEsladvvaRvlpaleel.....edgenvlvVsHggvirallayll

GDF
|  
glp
subfamily_STS_pd Subfamily STS 6-99 1.9e-08 26.0 In-house 3-114 (245) alignment 
Range on Protein: 6-99
Range on HMM: 3-114/245.0
LFVARHCERAA---------FArDGHF---DL----ELCHQEQAGKRRFWNDALTGEGTRQAVALSRDL--PVGSVRRIVASDWLRCVQTASIVARELG-
....|| ||           |  .|..   ||    || ..... |   ... ||  |  ||  | | |      .  |..|  |||.|||. .. .|| 
iyivRhgeRvdevfgkWlksfd.egkyerkdlnlpkelprrpdglkdyksDpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglgk

LTEIELDPALGEH
 ..|...|.|.| 
kikikvepgllew
0053607 Phosphoglycerate mutase-like 7-199 8.1e-12 37.6 In-house 5-156 (191) alignment 
Range on Protein: 7-199
Range on HMM: 5-156/191.0
FVARHCERAAFARDGHFDlelchqeqagkrrfwNDALTGEGTRQAVALSRDLP--VGSVRRIVASDWLRCVQTASIVarelGLTeIELDPALGEHEREAW
.. || |  . | . .                 .  || .| .|| || . |     .. ....|..||..||| |.    ||. .|.||.| |    .|
yLvRHGetewnaegrlqg...............dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii....glp.vevdprlrEidfgdw

FGetgsrpghlthslpELQDFVDATLG--------------PngqrillkphaqpfpdprRATDAWEVGEARTAAVAQAILTagvktFGHTLLVTHGGVG
 |                 . . ....              |                     . ..   ||. .. . .|       |..|.|.|||| 
eg..............ltleelaekypeelaawlrdpldyrp..................pggEsladvaaRvlpaleella.....ggnvlvVaHggvi

QRTVEALTG
.  .  |.|
rallayllg
0050036 Phosphoglycerate mutase-like 39-195 1.8e-11 36.2 In-house 23-142 (171) alignment 
Range on Protein: 39-195
Range on HMM: 23-142/171.0
WNDALTGEGTRQAVALSRDLpvgSVRRIVASDWLRCVQTASIVArelglTEIELDPALGEHEREAWFGETGSRPGHLTHSlpelqdfvdatlgpngqril
..  || .| .|| || . |   .. ....|. ||..||| ...      ....||.| |    || | | .   .                        
tdvpLtelgraqaralgell...pfdavysSpllRArqTaelil.....lpvivdprLrErdfGawegltldeiaakype....................

lkPHAQPFPDPRRATDAWEVGEARTAAVAQAILtagvktfGHTLLVTHGGVGQRTVE
   .. .. ..   .. ..   ||  .. . .|       |..|.|.||||    . 
..wlldlldlappggEsladvlaRvlpaleell.......gnvlvvaHggviralla
subfamily_TIGAR_pd Subfamily TIGAR 40-96 7.2e-06 17.8 In-house 24-83 (222) alignment 
Range on Protein: 40-96
Range on HMM: 24-83/222.0
NDALTGEGTRQAVALSRDLPVGSVRRIVASDWLRCVQTASIVARELGLTE---IELDPAL
.  |. .| .|| .... |    . .|..|| ||  |||.|. ..|   .   .| |. |
dtpLsekGveQakrvakrLsnekinyifsSdllRAkqTaeiilkalkekkreaverdkrL
Methyltransf_24 Methyltransferase domain 276-404 1e-20 61.1 Pfam-A 1-106 (106) alignment 
Range on Protein: 276-404
Range on HMM: 1-106/106.0
LELGSWEGLSMSMWLKELVSMHPeSCLVCIDHFDDmQTEAGQLRR-QRLHANTRCLTQHYkirvvprftlpalMDALHDFNgwhgdgpaiDEGFDLVYVD
.|.|...| |. ..|. |   .  ..|...|. .. . ||..| . . |... | | .                .||....         |. .||...|
vEiGvysGvstlvllqalkrnga.grlysvdpdpg.aeeaaalaeeagladrvrllkgds.............eealasla.........dgsiDllfiD

ADHAAHSTLLDALLAWRLLRKGGYLLFDDY
..|||...| |  .....|..|| .|.|||
gghaaeavladleallprlapggvvlldDy
Methyltransf_3 O-methyltransferase 365-409 7.7e-07 14.7 Pfam-A 119-161 (205) alignment 
Range on Protein: 365-409
Range on HMM: 119-161/205.0
DEGFDLVYVDADHAAHSTLLDALLawRLLRKGGYLLFDDYEWPTR
.  |||..|||| ... .  . ||  .|...|| . .|.  |  .
qgefDlifvDaDkssYknyyekll..eLvkvGgliaiDntLweGk