Gene MbreHP1-Un-3 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily HP1-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP111_AA protein Get Run
MbreP111_AA_0-214 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0051064 Phosphoglycerate mutase-like 1-208 4.1e-17 55.4 In-house 1-221 (241) alignment 
Range on Protein: 1-208
Range on HMM: 1-221/241.0
MATTRLLIVRHAERLDESRD-H-QaiqafmvrhrhtdRlYDCPITASGRQQARSAASHVASAVHTHAhmplpkdeadrvIIYCSLLQRCVQTADELAQGL
|...||..|||.|. .   . .               . .| |.|. ||.||| .. . |..    .            ..|.| |.|..|||. .|..|
mmmkrlyLvRHGesewnaegrlqg.............w.tDvpLtelGreqaralgerladlgikfd............avysSpllRaiqTaeiiaeal

PFATvlqpvaglascaaavndvgcanFNFLTDPELSALCATPV----------------LPALRNADA--------------------------------
.. .                       .. .||.|  ..                       ||.                                   
glpl......................lpvvvdprlrEidfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggE

--------FEEALDVLHAR--HPDHLIITVSHREGIRELKL--LNHHLSHAAKRRtPRYCAVAQFSHSPD
        ...||. | ||  .... .. |||   || |    |...|... . . . ...|  . ...|
sladvaaRvlpaleellarllldgknvlvVsHggvirallayllglpleellrln.lpngsvtvlelddd
0049178 Phosphoglycerate mutase-like 1-210 3.1e-15 49.0 In-house 1-221 (243) alignment 
Range on Protein: 1-210
Range on HMM: 1-221/243.0
MATTRLLIVRHAERLDESrdhqaiqafmvRHRHTDRlYDCPITASGRQQARSAASHVASAvhtH---AhmplpkdeadrvIIYCSLLQRCVQTADELAQG
| .|||..|||.|                 .|.... .| | |. ||.||| .. . |..   .   .            ..|.| |.|..|||. ....
mmmtrlyLvRHGetewna...........egrlqgw.tDspLtelGreqAralgellael...glkfd............avysSplkRaiqTaeiilea

LPFA-TVLQPVAGL----------ASCAAAVNDVGCANFNFLTDPELSALCATPVL---------------------PALRNADAFEEALDVLHAR--HP
|..    .. . .|           . | .   .. . .....||   .  |  .|                     .    |. ...||. | |.  |.
lglpllpvvvdprLrErdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhd

DHLIITVSHREGIRELK--LLNHHLSHAAKRRtPRYCAVAQFSHSPDAT
.. .. |.|   || |   ||...|..... . .....|  ......  
gktvlvVaHggvirallalllglpleellrln.lpngsvtvlelddggw
0037864 Phosphoglycerate mutase-like 1-205 5.9e-14 44.5 In-house 1-197 (211) alignment 
Range on Protein: 1-205
Range on HMM: 1-197/211.0
MA----TTRLLIVRHAERLDEsrdhqaiqafmVRHRHTDRlYDCPITASGRQQARSAASHVASAVHTHAHmplpkdeadrviIYCSLLQRCVQTADELAQ
|.    .|||..|||.|. .            . .|.... .| |.|. ||.||| .. ..|.. ..  .            .|.| |.|..|||. ...
MslnllmtrlyLvRHGetewn...........aegrlqgw.ldvpLtelGreqaralgealadlglpfda............vysSpllRaiqTaeiile

GLpfatvlqpvaglascaaavndvG----------------CANFNFLTDPELSAlcATPVLPALRNADA-----------------FEEALDVLHARH-
.|                      |                   .. || .|. .  . | ... . .|                  ...||. | ||. 
al......................glpllpvevdprlrErdfgalegltleeiae..kypeelvawlrdpydfrppggEsladvvaRvlpaleellarll

-PDHLIITVSHREGIRELKLLNHHLSHA--AKRrTPRYCAVAQFSH
 ... .. |||   .| |  .  .|| .   .     ...|. . .
kdgenvlvVsHggvlrallayllglsleellrl.nlpngsvtvlel
0036887 Phosphoglycerate mutase-like 3-210 3e-16 52.2 In-house 1-190 (202) alignment 
Range on Protein: 3-210
Range on HMM: 1-190/202.0
TTRLLIVRHAERLDESrdhqaiqafmvRHRHTDRlYDCPITASGRQQARSAASHVAsavHThahmplpkdeaDRVIIYCSLLQRCVQTADELAQGLPfat
.|||..|||.|. .              .|.... .| |.|. ||.||| .. ..|   .            .  ..|.| |.|..|||. .|..|.   
mtrlyLvRHGetewnv...........egrlqgd.ldvpLtelGreqaralgerla...gl...........pfdavysSpllRaiqTaeiiaealg...

vlQPvaglASCAAAVNDVGCANFNFLTDPELSAlcATPVLPALRNADA-----------------FEEALDVLHARHPDHLIITVSHREGIRELKL--LN
   |         . ...    .. || .|. .    | . | . .|                  ...||. | ||.... .. |||   .| |    |.
..lp....vivdprlrEidfgalegltleeiae..kypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllg

HHLSHAAKRRTPRYCAVAQFSHSPDAT
 .| .. . | .....|  ......  
lsledllrlrklpngsvtvlelddggw
0036777 Phosphoglycerate mutase-like 3-209 4e-14 45.3 In-house 2-221 (247) alignment 
Range on Protein: 3-209
Range on HMM: 2-221/247.0
TTRLLIVRHAERLDESrdhqaiqafmvRHRHTDRlYDCPITASGRQQARSAASHVASAvhtH---AhmplpkdeadrvIIYCSLLQRCVQTADELAQGLP
..||..|||.|  .              .|.... .| |.|. ||.||. .. .....   .                ..|.| |.|..|||. ....|.
mkrlyLvRHGetewna...........egrfqgw.lDvpLtelGreqakalgellkel...glpfd............avysSpllRAiqTaeiilealg

FA-TVLQPVAGLA----------SCAAAVNDVGCANFNFLTDPELSALCA--------------TPVLPALRNADA---------FEEALDVLHAR--HP
.    ..   .|           . | . . .. . . ...||   .                 ...||.    ..          ..||. | ||  ..
lsllpvvvdprLrErdyGalegltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkd

DHLIITVSHREGIRELKLLNHHLSHA--AKRrTPRYCAVAQFSHSPDA
.. .. |||   .| |  .  .|| .  ..     ....  .   .| 
genvlvVsHggvlrallayllglsledilrl.nlpngsitvleldddg
0043909 Phosphoglycerate mutase-like 3-209 8.4e-14 44.1 In-house 2-225 (249) alignment 
Range on Protein: 3-209
Range on HMM: 2-225/249.0
TTRLLIVRHAERLDESRdhqaiqafmvrHRHTDrLYDCPITASGRQQARSAASHVASAvhthA---HmplpkdeadrvIIYCSLLQRCVQTADELAQGLP
..||..|||.|  .              .|...  .| |.|. ||.||| .. .....        .           ..|.| |.|..|||  ....|.
mkrlyLvRHGetewnae...........grfqg.wlDspLtelGreqaralgealkel....gipfd...........avysSplkRAiqTaeiileelg

FA-TVLQPVAGL----------ASCAAAVNDVGCANFNFLT----------DPELSALCATPVLPALRNADA-----------------FEEALDVLHAR
.    ..   .|           . | . . .. . ...|.          ..    |   .. .||...|                  ...||. | ||
ldklpvevdprLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellar

--HPDHLIITVSHREGIRELKLLNHHLSHAAK-RRTPRYCAVAQFSHSPDA
  .... .. |.|   .| |  . ..|| ..  |    ....  .  ... 
llkdggnvliVaHggvlrallayllglsledilrlnlpngsitvlelddgg
0053607 Phosphoglycerate mutase-like 4-208 2.3e-11 36.2 In-house 2-180 (191) alignment 
Range on Protein: 4-208
Range on HMM: 2-180/191.0
TRLLIVRHAERLDESRdhqaiqafmvrHRHTDrlyDCPITASGRQQARSAASHVASAvhthA----HmplpkdeadrviIYCSLLQRCVQTADELaqglp
|||..|||.|                 .|..    | |.|. ||.||| .| . |.          .            .|.| |.|..|||. .     
trlyLvRHGetewnae...........grlqg...dvpLtelGreqaralaellael....glkfda............vysSpllRarqTaeii.....

fatvlqpvaglaS----CAAAVNDVGCANFNFLTDPELSALCATPVLP-------------------ALRNADAFEEALDvlharhpDHLIITVSHREGI
            .       . ....   .. ||  || .     .                     | |  .|.|| |.       .. .. |.|   |
............glpvevdprlrEidfgdwegltleelaekypeelaawlrdpldyrppggEsladvaaRvlpaleella.......ggnvlvVaHggvi

RELKLLNHH--LSHAAKRRtPRYCAVAQFSHSPD
| |  .  .  |... . . .....|  ......
rallayllglpleellrln.lpngsvtvlelddg
0048955 Phosphoglycerate mutase-like 5-210 2.7e-16 52.7 In-house 2-219 (240) alignment 
Range on Protein: 5-210
Range on HMM: 2-219/240.0
RLLIVRHAERLDE--SRDHQaiqafmvrhrhtdrLYDCPITASGRQQARSAASHVASAVHTHAhmplpkdeadrvIIYCSLLQRCVQTADELAQGLpfat
||..|||.|. .    | .                .| |.|. ||.||| .. . |.. .  .            ..|.| |.|..|||. .|..|    
rlyLvRHGesewnaegrlqg..............wtDvpLtelGreqaralgerLadlgikfd............lvysSpllRaiqTaeiiaeal....

vlqpvaglascaaavndvG---------------------------------CANFNFLTDPELSALCA-----------------------TPVLPALR
                  |                                  . . .|.||   . .                            .   
..................glpllpvvvdprlrErdfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEslad

NADAFEEALDVLHARH--PDHLIITVSHREGIRELKLLNHHLSH--AAKRRtPRYCAVAQFSHSPDaT
 |. ...||. |.||.  |.. .. |||   || |    ..|.   ... . . ...|  ......  
vaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeilrln.ipngsvtvlelddg.l
0035570 Phosphoglycerate mutase-like 5-209 1.1e-13 43.6 In-house 1-179 (219) alignment 
Range on Protein: 5-209
Range on HMM: 1-179/219.0
RLLIVRHAERLDESrdhqaiqafmvRHRHTDrlyDCPITASGRQQARSAASHVASAVhthahmplpkdeADRVIIYCSLLQRCVQTADELaqglpfatvl
||..|||.|. .              .|...   | |.|. ||.||| .. . |.               .  ..|.| |.|..|||. .          
rlyLvRHGetewnl...........egrlqg...dvpLterGreqaralgealadlg............ipfdavysSpllRaiqTaeii..........

qpvaglascA------AAVNDVGCANFNFLTDPELSALCAtpVLPALRNADA----------FEE----ALDV---LharHPDHLIITVSHREGIRELKL
                 . ....   .. || .|. ..     . |.. .|           ...    .|..   |   .... .. |||   || |  
.........glpveidprLrEidfgdlegltldeiaekyp..eelaawlrdpydyrppggEsladvvaRvlpaleel...edgenvlvVsHggviralla

LNH--HLSHAAKRRtPRYCAVAQFSHSPDA
.    .|..... .   ...|  ... .. 
yllglpleeilrln.lpngsvtvleldggg
0039931 Phosphoglycerate mutase-like 5-214 4.8e-13 41.6 In-house 1-184 (219) alignment 
Range on Protein: 5-214
Range on HMM: 1-184/219.0
RLLIVRHAERLDESrdhqaiqafmvRHRHTDrlyDCPITASGRQQARSAASHVASAVHTHahmplpkdeadrVIIYCSLLQRCVQTADELaqGLPfatvL
||..|||.|  .              .|...   | |.|. ||.||| .. . ..                  ..|.| |.|..|||. .  |||    .
rlyLvRHGetewnv...........egrlqg...dspLterGreqaralgerlkdlglpf............davysSpllRaiqTaeii..glp....v

QPVaglascaAAVNDVGCANFNFLTDPELSALCATPVLPALRN--------ADA-------FEEALDVLHArhpDHLIITVSHREGIRELKLLNHH--LS
.          . ....   .. || .|. ..    .   ||.        ..        ...||. | |   .. .. |||   || |  .  .  |.
eid.......prLrEidfgdlegltleeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleella...genvlvVsHggvirallayllglsle

HAAKRrTPRYCAVAQFSHSPDATCHWT
....   . ...|  ......  . ..
eilrl.nlpngsvtvlelddggwvlvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 5-125 8.8e-13 41.5 Pfam-A 1-72 (158) alignment 
Range on Protein: 5-125
Range on HMM: 1-72/158.0
RLLIVRHAERLdesrdhqaiqaFMVRHRHTDRLYDcPITASGRQQARSAASHVASavhthahmplpkDEADRVIIYCSLLQRCVQTADELAQGLPfatvl
||..|||.|.            .  ..|.. .  . |.|. ||.|||... . ..            ..     .|.| |.|..|||. |...|      
rlylvRHGese...........wnkegrlqgwsdv.pLtekGreqarelgkkLkr............adlpidavytSplkRaiqTaeilleeld.....

qpvaglascaaavndvgcanF
                     
....................i
His_Phos_1 Histidine phosphatase superfamily (branch 1) 5-125 8.8e-13 41.5 In-house 1-72 (158) alignment 
Range on Protein: 5-125
Range on HMM: 1-72/158.0
RLLIVRHAERLdesrdhqaiqaFMVRHRHTDRLYDcPITASGRQQARSAASHVASavhthahmplpkDEADRVIIYCSLLQRCVQTADELAQGLPfatvl
||..|||.|.            .  ..|.. .  . |.|. ||.|||... . ..            ..     .|.| |.|..|||. |...|      
rlylvRHGese...........wnkegrlqgwsdv.pLtekGreqarelgkkLkr............adlpidavytSplkRaiqTaeilleeld.....

qpvaglascaaavndvgcanF
                     
....................i
subfamily_STS_pd Subfamily STS 5-99 2.5e-07 22.4 In-house 2-100 (245) alignment 
Range on Protein: 5-99
Range on HMM: 2-100/245.0
RLLIVRHAERLDESRDHqAIQ---------------AFMVRH--RHTDRLYDCPITASGRQQARSAASHVASAVHTHAHmplpkdeadrviIYCSLLQRC
...||||.|| ||   .  ..                 ..|.    .|   | |.|..| .||.  . .  .|  .  |            |.||   ||
tiyivRhgeRvdevfgk.WlksfdegkyerkdlnlpkelprrpdglkdyksDpPlterGviqAkllgraLleagikieh............ifcSPslrc

VQTADELAQGLP
.|||  ...|| 
iqTaaailkglg
0049059 Phosphoglycerate mutase-like 7-126 7.2e-06 18.3 In-house 48-188 (435) alignment 
Range on Protein: 7-126
Range on HMM: 48-188/435.0
LIVRHAERLDESRDHQAIQAFMVRHRHTDRLYDCP---------------ITASGRQQARSAASHVASAVhthAHMplpkDEADRVIIYCSLLQRCVQTA
...|| .|   |   . ..|.  .  .. . .. |                |. ||.||.  . .  .      ..       | | .. |  .|..|.|
vlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrY...gfL....ynpdevyvrssdvdRtlqSa

DELAQGLPFAT-----------VLQPVAG--LASCAAAVNDVGCANFN
  ...||               | |||.     |    ..   |..|.
qaflaGlfppeilgsqllnplnvyqpvpietvdsdndtlpydscpafd
0053031 Phosphoglycerate mutase-like 8-126 6e-06 19.0 In-house 9-133 (342) alignment 
Range on Protein: 8-126
Range on HMM: 9-133/342.0
IVRHAERLDesrdhqaiQAFMVRHRHTDRLYDC---PITASGRQQARSAASHVASAVhtHAHMPlPKDEADRVIIYCSLLQRCVQTADELAQGL--PFA-
.||| .|          ....   .. .  |.|   . |  ||.||.    .  .    .  .| ..   |.| .. |  .|..|.|  ...||  |   
lvRHGaRtP........lskgpldplnewfypcgageLTplGreqayelGrrlrkrY..lgllp.stynpdevyvrssdvdRtlqSAqaflaGlfppegt

-----------TVLQPVAGLASCAAAVNDVGCANFN
             .. ..   .     |   |..|.
pilnpllgwqpipihtepessdalllpnydpcpafd
0050036 Phosphoglycerate mutase-like 27-102 1.6e-09 29.9 In-house 13-64 (171) alignment 
Range on Protein: 27-102
Range on HMM: 13-64/171.0
FMVRHRHTDRlYDCPITASGRQQARSAASHVasavhthahmplpkdeaDRVIIYCSLLQRCVQTADELAqglpfaT
. . .|.... .| |.|. ||.||| .. .                  .  ..|.| |.|..|||. ..       
wnlegrfqgw.tdvpLtelgraqaralgell.................pfdavysSpllRArqTaelil......l