Gene HP1LE in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily HP1LE
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP112_AA protein Get Run
MbreP112_AA_142-300 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0035570 Phosphoglycerate mutase-like 143-294 4.2e-24 77.7 In-house 20-163 (219) alignment 
Range on Protein: 143-294
Range on HMM: 20-163/219.0
GlepEYGLTETGKEQAIAAAMRLKRQvrRVEDVIIYSSDFARARETALCVaatlKLAePNVDQRLRERFFGTLDLgpsQHYEDVWE--------HDAHSA
|   ...|||.|.||| |.. .|...  ...  ..|||.. ||..||  .    .|  . .| ||||. || |.    .......|        . ....
g...dvpLterGreqaralgealadl..gipfdavysSpllRaiqTaeii....glp.veidprLrEidfgdleg...ltldeiaekypeelaawlrdpy

SHTQYDVEPLESVVTRMSAVVEHCeqtHDNAIVVLVAHGDPLQILQTWFLDVSPCLHRRY
 ..  . |.|. || |. ...|.    .|.  |..|.|| ....|  ..|....   .| 
dyrppggEsladvvaRvlpaleel...edgenvlvVsHggvirallayllglpleeilrl
0039931 Phosphoglycerate mutase-like 143-300 1.6e-23 75.7 In-house 20-168 (219) alignment 
Range on Protein: 143-300
Range on HMM: 20-168/219.0
GlepEYGLTETGKEQAIAAAMRLKRQvrRVEDVIIYSSDFARARETALCVaatlKLAePNVDQRLRERFFGTLDLG-----PSQHYEDVWEHDAHSASHT
|   ...|||.|.||| |.. |||..  ...  ..|||.. ||..||  .    .|  . .| ||||. || |.         .. |... . .... ..
g...dspLterGreqaralgerlkdl..glpfdavysSpllRaiqTaeii....glp.veidprLrEidfgdlegltleeiaekypeelaawlrdpydyr

QYDVEPLESVVTRMSAVVEHCEQthdNAIVVLVAHGDPLQILQTWFLDVSPCLHRRYaHLTTG
  . |.|. || |. ...|. ..   .  |..|.|| ....|  ..|..|.   .|. .| .|
ppggEsladvvaRvlpaleella...genvlvVsHggvirallayllglsleeilrl.nlpng
0053607 Phosphoglycerate mutase-like 143-295 7.1e-23 73.6 In-house 22-166 (191) alignment 
Range on Protein: 143-295
Range on HMM: 22-166/191.0
GlepEYGLTETGKEQAIAAAMRLKRQvrRVEDVIIYSSDFARARETALCVaatlkLAEPNVDQRLRERFFGTLDLGPSQHYED-----VWEHDAHSASHT
|   ...|||.|.||| |.| .|...   ..  ..|||.. |||.||  .       .. || ||||. || ..  . . ...     .. . ...  ..
g...dvpLtelGreqaralaellael..glkfdavysSpllRarqTaeii.....glpvevdprlrEidfgdwegltleelaekypeelaawlrdpldyr

QYDVEPLESVVTRMSAVVEHCEQthdNAIVVLVAHGDPLQILQTWFLDVSPCLHRRYA
  . |.|. |..|. ...|.  .   .  |..|||| ....|  ..|....  ..|. 
ppggEsladvaaRvlpaleella...ggnvlvVaHggvirallayllglpleellrln
0037864 Phosphoglycerate mutase-like 144-300 1.4e-26 85.7 In-house 29-190 (211) alignment 
Range on Protein: 144-300
Range on HMM: 29-190/211.0
LePEYGLTETGKEQAIAAAMRLKRQvrRVEDVIIYSSDFARARETALCVAATLKL--AEPNVDQRLRERFFGTLDL-----GPSQHYEDVWEHDAHSASH
  ....|||.|.||| |.. .|...   ..  ..|||.. ||..||  ... |.|   .. || |||||.|| |.        ... |. . . .... .
w.ldvpLtelGreqaralgealadl..glpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltleeiaekypeelvawlrdpydf

TQYDVEPLESVVTRMSAVVEHCEQTH--DNAIVVLVAHGDPLQILQTWFLDVSPCLHRRYaHLTTG
.  . |.|..|| |. ...|.  ...  |.  |..|.|| .| .|  ..|..|.  ..|. .| .|
rppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrl.nlpng
0048439 Phosphoglycerate mutase-like 144-197 8.2e-06 18.5 In-house 40-107 (391) alignment 
Range on Protein: 144-197
Range on HMM: 40-107/391.0
LEPEYG---LTETGKEQAIAAAMRLKRQV---------R--RVEDVIIYSSDFARARETALCVAATLK
.  ..|   ||..|.||...   || .                ..| ..|||. |....| ...| | 
pngpcglgeLTplGreqlyelGrrlrkrYvdlgllpskytlnpsevyvrssdvdRtlqSAqaflaGlf
0049178 Phosphoglycerate mutase-like 146-299 1.7e-26 85.8 In-house 26-208 (243) alignment 
Range on Protein: 146-299
Range on HMM: 26-208/243.0
PEYGLTETGKEQAIAAAMRLKRQvrRVEDVIIYSSDFARARETALCVAATLKL--AEPNVDQRLRERFFGTLDlgpSQHYEDVWEHD--------AHSAS
....|||.|.||| |.. .|...   .   ..|||.  ||..||  ....|.|   .. || ||||| ||.|.    .........         ...  
tDspLtelGreqAralgellael..glkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGale...gltkaeiaakypeelvawwrdpyd

HTQ-----------------------YDVEPLESVVTRMSAVVEHCEQT--HDNAIVVLVAHGDPLQILQTWFLDVSPCLHRRYAhLTT
..                         . |.|. |..|. ...|.  ..  ||.  |..|||| .. .|  ..|....  ..|.  | .
arppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleellrln.lpn
0036887 Phosphoglycerate mutase-like 146-300 2.3e-26 85.1 In-house 24-178 (202) alignment 
Range on Protein: 146-300
Range on HMM: 24-178/202.0
PEYGLTETGKEQAIAAAMRLKrqvrRVEDVIIYSSDFARARETALCVAATLKlAEPNVDQRLRERFFGTLDLGPSQH-----YEDVWEHDAHSASHTQYD
....|||.|.||| |.. ||.     .   ..|||.. ||..||  .|..|.  .. || ||||..|| |.  . .       |... . .... ..  .
ldvpLtelGreqaralgerla....glpfdavysSpllRaiqTaeiiaealg.lpvivdprlrEidfgalegltleeiaekypeelaawlrdpydfrppg

VEPLESVVTRMSAVVEHCEQTHDNAIVVLVAHGDPLQILQTWFLDVSPCLHRRYAHLTTG
 |.|. || |. |..|.  ...|.  |..|.|| .| .|  ..|..|.  ..|. .| .|
gEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpng
0036777 Phosphoglycerate mutase-like 146-300 5e-26 84.2 In-house 25-210 (247) alignment 
Range on Protein: 146-300
Range on HMM: 25-210/247.0
PEYGLTETGKEQAIAAAMRLKRQvrRVEDVIIYSSDFARARETALCVAATLK--LAEPNVDQRLRERFFGTLDlgpSQHYEDVWEHDAH--------SAS
.. .|||.|.||| |.. .||..   .   ..|||.. ||..||  ....|.  | .. || ||||| .|.|.    .......|.  .        .. 
lDvpLtelGreqakalgellkel..glpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGale...gltkaeiaekypeelvawwrdpyd

HTQ-------------------------YDVEPLESVVTRMSAVVEHCEQT--HDNAIVVLVAHGDPLQILQTWFLDVSPCLHRRYaHLTTG
..                           . |.|. || |. ...|.  ..  .|.  |..|.|| .| .|  ..|..|.   .|. .| .|
yrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsledilrl.nlpng
0051064 Phosphoglycerate mutase-like 146-295 2e-25 82.5 In-house 26-207 (241) alignment 
Range on Protein: 146-295
Range on HMM: 26-207/241.0
PEYGLTETGKEQAIAAAMRLKRQVRRVEdvIIYSSDFARARETALCVAATLKL--AEPNVDQRLRERFFGTLDLGPSQH-----YEDVWEHDAHSASHTQ
.. .|||.|.||| |.. ||...  ...  ..|||.. ||..||  .|. |.|   .. || ||||..|| |.  . .       |... .. ..  .. 
tDvpLtelGreqaralgerladlgikfd..avysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltleeiaekfpeelvawlrdpldvrp

-------------------------YDVEPLESVVTRMSAVVEHCEQT--HDNAIVVLVAHGDPLQILQTWFLDVSPCLHRRYA
                          . |.|. |. |. ...|.. ..  .|.  |..|.|| .. .|  ..|....  ..|. 
pllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglpleellrln
0048955 Phosphoglycerate mutase-like 146-294 3.4e-25 81.8 In-house 23-203 (240) alignment 
Range on Protein: 146-294
Range on HMM: 23-203/240.0
PEYGLTETGKEQAIAAAMRLKRQvrRVEDVIIYSSDFARARETALCVAATLKL--AEPNVDQRLRERFFGTLDLGPSQH-----YEDVWEHDAHSASHTQ
.  .|||.|.||| |.. ||...   .   ..|||.. ||..||  .|. |.|   .. || |||||.|| |.  . .       |... . ... ... 
tDvpLtelGreqaralgerLadl..gikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiaekfpeelvlwlrdpldvrp

-------------------------YDVEPLESVVTRMSAVVEHCEQTH--DNAIVVLVAHGDPLQILQTWFLDVSPCLHRRY
                          . |.|. |. |. |..|.. ...  ..  |..|.|| ..  |  ..|....   .|.
pllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeilrl
0043909 Phosphoglycerate mutase-like 147-300 9.9e-26 83.1 In-house 26-214 (249) alignment 
Range on Protein: 147-300
Range on HMM: 26-214/249.0
EYGLTETGKEQAIAAAMRLKRQvrRVEDVIIYSSDFARARETALCVAATLKL--AEPNVDQRLRERFFGTLDlgpSQHYEDVWEHDA-------------
. .|||.|.||| |.. .||..  ..   ..|||.. ||..||  ... |.|   .. || |||||.|| |.    .......|.               
DspLtelGreqaralgealkel..gipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGale...gltkaeiaekypeelvawlrrsydv

------------------------HSASHTQYDVEPLESVVTRMSAVVEHCEQT--HDNAIVVLVAHGDPLQILQTWFLDVSPCLHRRYaHLTTG
                        .. ... .. |.|. || |. ...|.  ..  .|.  |..||||  | .|  ..|..|.   .|  .| .|
lpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllglsledilrl.nlpng
0050036 Phosphoglycerate mutase-like 147-293 3.6e-20 64.4 In-house 24-154 (171) alignment 
Range on Protein: 147-293
Range on HMM: 24-154/171.0
EYGLTETGKEQAIAAAMRLkrqvrrvEDVIIYSSDFARARETALCVAatlklAEPNVDQRLRERFFGTLDLGP-SQHYEDVWEHDAHSASHTQYDVEPLE
...|||.|..|| |.. .|       .  ..|||.  |||.||  ..      .. || ||||| || ..  . .. .. ..|.... . ..  . |.|.
dvpLtelgraqaralgell.......pfdavysSpllRArqTaelil.....lpvivdprLrErdfGawegltldeiaakypewlldlldlappggEsla

SVVTRMSAVVEHCEqthdnAIVVLVAHGDPLQILQTWFLDVSPCLHRR
 |..|. ...|.         |..||||  . .|  ..|..|.  ..|
dvlaRvlpaleell.....gnvlvvaHggvirallalllglsleeilr
His_Phos_1 Histidine phosphatase superfamily (branch 1) 147-278 2e-19 63.1 Pfam-A 24-157 (158) alignment 
Range on Protein: 147-278
Range on HMM: 24-157/158.0
EyGLTETGKEQAIAAAMRLKRQVRRVEDviIYSSDFARARETALCVAATLKlAEPNVDQRLRERFFGTLDlGPSQ-HYED----VWEHDAHSASHTQY-D
.  |||.|.||| ... .|||.  ...   .|.|.. ||..||  ... |.  .   ..||||| ||... | .. . ..     .|.      . .. .
v.pLtekGreqarelgkkLkradlpida..vytSplkRaiqTaeilleeld.ipiikeprLrerdfgewe.glpkeevkeefpeeyekwkrdkkefrppe

VEPLESVVTRMSAVVEHCEQ-THDNAIVVLVAHGDPLQI
 | |. |..|.....|.  . ....  |..|.||  |. 
gesladvyeRvapfleelieakdkgenvlivsHggvlra
His_Phos_1 Histidine phosphatase superfamily (branch 1) 147-278 2e-19 63.1 In-house 24-157 (158) alignment 
Range on Protein: 147-278
Range on HMM: 24-157/158.0
EyGLTETGKEQAIAAAMRLKRQVRRVEDviIYSSDFARARETALCVAATLKlAEPNVDQRLRERFFGTLDlGPSQ-HYED----VWEHDAHSASHTQY-D
.  |||.|.||| ... .|||.  ...   .|.|.. ||..||  ... |.  .   ..||||| ||... | .. . ..     .|.      . .. .
v.pLtekGreqarelgkkLkradlpida..vytSplkRaiqTaeilleeld.ipiikeprLrerdfgewe.glpkeevkeefpeeyekwkrdkkefrppe

VEPLESVVTRMSAVVEHCEQ-THDNAIVVLVAHGDPLQI
 | |. |..|.....|.  . ....  |..|.||  |. 
gesladvyeRvapfleelieakdkgenvlivsHggvlra
subfamily_TIGAR_pd Subfamily TIGAR 148-258 4.8e-13 41.3 In-house 25-134 (222) alignment 
Range on Protein: 148-258
Range on HMM: 25-134/222.0
YGLTETGKEQAIAAAMRLKRqvrrVEDVIIYSSDFARARETALCVAATLKLAEPN---VDQRLRERFFGTLDLGPSQHYEDVWEHDAHSASHTQYDVEPL
  |.|.| |||...| ||.      . . |.|||  ||..||  .   ||  ...   .|.||||| .| .     . ....      . |..    | .
tpLsekGveQakrvakrLsn....ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelrellkaagnvpsfvpegGesi

ESVVTRMSAVVEHC
| . .|..| .|. 
eqlelrlvaaleel
0047369 Phosphoglycerate mutase-like 149-290 2.7e-10 33.1 In-house 98-253 (438) alignment 
Range on Protein: 149-290
Range on HMM: 98-253/438.0
GLTETGKEQAIAAAMRLKRQ---VrRVEDV-IIYSSDFARARETALCVAATLK--------------LAEPNVDQRLRERFFGTLDLGPSQHYEDVWEHD
 ||..|.|||..   || .        |||  ..|||. |....| ...| |                .  ... . .. ....|. .. . ...... .
qLTplGreqayelGkrlrkrYglL.npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtipesddfllnllpsdscpafdellkef

AHSASHTQYDvepLESVVTRMSAVVEHCEQTHDNAIVVLVAHGDPLQILQTWFLDVSPCL
. |..  .     |...  |.. . . .. | .... . . . . ....... |  || .
lasdeflell...lkdilkrlkkllpglnltpsdvldlydlcaydtlangyaglplspfc
subfamily_PFKFB_pd Subfamily PFKFB 149-287 7.2e-10 30.6 In-house 30-164 (198) alignment 
Range on Protein: 149-287
Range on HMM: 30-164/198.0
GLTETGKEQAIAAAMRLKRqvRRVEDVIIYSSDFARARETALCVaatlKLAEPNVDQrLRERFFGTLDLGPSQHYEDVWEHDAHSASHTQYD-----VEP
 ||| |.|.| ..|  .|.    ........| ..|. .||  .    .| . .. . |.|.  |..|    .  .. . .. .  .. .|       | 
eLterGveyakklakfike..enlkelrvwtselkrtiqTaell....glpkeqwka.LdeldaGkcdgltyeeikekfpeefkerkkdkyryryprgEs

LESVVTRMSAVVEHCEQTHDNaiVVLVAHGDPLQILQTWFLDVS
 | .|.|.  |.   |....|  |...||   |..|  ..|| |
yedlvqRlepvileLereqen..vliiaHqavlrvllaylldks
0049059 Phosphoglycerate mutase-like 149-273 9.6e-08 24.5 In-house 97-245 (435) alignment 
Range on Protein: 149-273
Range on HMM: 97-245/435.0
GLTETGKEQAIAAAMRLKRQ---VRRVEDVIIYSSDFARARETALCVAATL-------------KLAEPNVDQRLRERFFGTLDLGPSQHYEDVWEHDAH
 ||..|.|||.  . || .      . ..| ..|||. |....| ...| |                   |  . ..... ||.  . . ...... .. 
eLTplGreqayelGkrlrkrYgfLynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtlpydscpafdellkella

SASHTQYDvepLESVVTRMSAVVEHCEQTHDNAIVVLV-----------AHG
|.   .     ||..  ... . .....| ..   .             |||
sdeflelf...lerilkllqellpglgltpsdvldlydlckydtlllgyahg
0053031 Phosphoglycerate mutase-like 150-292 1.1e-08 28.0 In-house 38-197 (342) alignment 
Range on Protein: 150-292
Range on HMM: 38-197/342.0
LTETGKEQAIAAAMRLKRQVR-------RVEDVIIYSSDFARARETALCVAATLKLAEPN-----------VDQRLRERFFGTLDLGPSQHYeDVWEHDA
||..|.|||..   ||..          . ..| ..|||. |....| ...| |   |.            ..    .. ...| |...... . ...  
LTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllpnydpc.pafdkll

HSASHTQYDVEPLESVVTRMSAVVEHCEQTHDNAIVVLVAHGDPLQILQTWFLDVSPCLHR
..| ....  | ||..  ..... .....|...   ..    | |.. ... |...|..  
kealaseevkellerylellqklskglgltlsdlldlvsdlydlllyelahglplppwctl
subfamily_PGAM_pd Subfamily PGAM 150-241 1.9e-07 22.6 In-house 27-118 (248) alignment 
Range on Protein: 150-241
Range on HMM: 27-118/248.0
LTETGKEQAIAAAMRLKRQVRRVedVIIYSSDFARARETALCVAATLKLAEPNV--DQRLRERFFGTLDLGPSQHYEDVWEHDAHSASHTQYDV
|.|.|||.| .|.  ||..  ..   |.|.|.  ||..|.  .   |. .   |  . ||.|| .|.|     ..  . . ..   .   .|||
LsekGkeeAkkagkalkqanlef..divytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaevakkyGeekvkiwRRsydv
0049226 Phosphoglycerate mutase-like 150-204 8.5e-06 18.4 In-house 38-97 (342) alignment 
Range on Protein: 150-204
Range on HMM: 38-97/342.0
LTETGKEQAIAAAMRLKRQ-------VRRVEDVIIYSSDFARARETALCVAATLKlaEPNVD
||..|.|||.. . ||..          . ..| ..|||. |. ..| ...| |   .|.  
LTplGreqayelGrrlrkrYlgllpstynpdevyvrssdvdRtlqSaqaflaGlf..ppelt