Gene PFKFB in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP113_AA protein Get Run
MbreP113_AA_292-508 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 46-81 3.1e-13 39.7 Pfam-A 11-46 (223) alignment 
Range on Protein: 46-81
Range on HMM: 11-46/223.0
AEKLAVVMVGLPARGKTYIATKLAYYLNWVMLKTRD
..||..|.|||||||||||..||  ||.|. ..|. 
nsklvivlvGLpargKtyiskkltrylkwlgvrtkv
AAA_33 AAA domain 51-223 2.8e-09 27.5 Pfam-A 2-120 (143) alignment 
Range on Protein: 51-223
Range on HMM: 2-120/143.0
VVMVGLPARGKTYIATKLAYYLNWVMLKTRDlslslslslslslslslminliltampllavlrdcwfthvavfnlgrYRREKYGPQSPamffHPNNTAG
|..||||. ||.. | .|.  | .| | . .                                               .||. .| ...    .... . 
vllvGlpGsGKstlaerllkklgyvrlsqdt...............................................lrrrlfgtdqq....sltdytr

VEQRrllALEAIDDVMEWLKSGGVCAVFDATNSARERRMMIFRELTQRGVPVFFVESVCNDDDQITRNIMQVK
|..|   ..... .. ..  | |  ...||||  ||.|. . . . . ||||  |   . ..    |.    .
vlkr...lyqilnklarkalsagrsvivdatnlsreerarfvklakrlgvpvrivylevpeetlaeRlakRer
6PF2K 6-phosphofructo-2-kinase 121-298 3.7e-56 180.0 Pfam-A 44-222 (223) alignment 
Range on Protein: 121-298
Range on HMM: 44-222/223.0
VAVFNLGRYRREKYGPQSPAMFFHPNNTAGVEQRRLLALEAIDDVMEWLK-SGGVCAVFDATNSARERRMMIFRELTQRGVPVFFVESVCNDDDQITRNI
  |||.|.||||.   .| | ||.|.|. ... |. |||.|..|....|.  .|  |.|||||. |||| .|......... |.|.||||.| . |..||
tkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDAtNttrerRklilefveennlkvlflesvcsdeeiikeNi

MQVKVGLPDYMSSTVEAAVSDFKERIDYYKMLYEPLHVDVDRALSFIKLVDVGRYFLVHRCEGYLQMRISRFLMNIHIE
..||.. |||  .. | |..||..|.. |.  ||||. . |. ||.||..|||. ..|.. .|||| ||  .|.||| .
kevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvvnnvqgylqsrivyyllNihlk
0037864 Phosphoglycerate mutase-like 293-502 5.2e-42 135.9 In-house 1-205 (211) alignment 
Range on Protein: 293-502
Range on HMM: 1-205/211.0
MNIHIEKRHIYISRHGESMYNTKGLIGG--DSDLSPRGRLYARRLRNFMAKFvSW---RsdgdgdgddtngekldnlrVWCSSLNRTIQTVEHF------
|....  ...|. ||||...|..|.. |  |..|...|| .||.|....|..  .   .                   |..| | |.||| |..      
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadl.glpfda...................vysSpllRaiqTaeiilealgl

--RYKEAWKALDELDAGECDGLSYEETKERFPEMYKERQGNKYWTRYPRGESYADVVQRLEPRIMELERMR----DNVLVVCHQAVARCLLAYFQNMSdl
     | ...| |.| |...||..||..|..||..  .. ..|..|.| |||.||||.|..| ..|| ..     .|||||.|..| |.||||. ..|  
pllpvevdprlrErdfgalegltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllgls..

ADQLPYLKIPLHTVFKITPIPYGNRIE
 ..|..|..| ..|....  ..| ...
leellrlnlpngsvtvlelddggwvlv
subfamily_PFKFB_pd Subfamily PFKFB 294-508 3.7e-89 289.4 In-house 1-197 (198) alignment 
Range on Protein: 294-508
Range on HMM: 1-197/198.0
NIHIEKRHIYISRHGESMYNTKGLIGGDSDLSPRGRLYARRLRNFMAKfvswrsdgdgdgddtngEKLDNLRVWCSSLNRTIQTVEHFRYK-EAWKALDE
|||...|.||..|||||..|.|| |||||.|..||. ||..|..|...                 |.|..||||.|.|.|||||.|..... |.||||||
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfike.................enlkelrvwtselkrtiqTaellglpkeqwkaLde

LDAGECDGLSYEETKERFPEMYKERQGNKYWTRYPRGESYADVVQRLEPRIMELERMRDNVLVVCHQAVARCLLAYFQNMSdlADQLPYLKIPLHTVFKI
||||.||||.|||.||.|||..|||. .||. ||||||||.|.|||||| |.||||...|||...||||.|.||||....|  |..|||||.|||||.|.
ldaGkcdgltyeeikekfpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldks..aeelpylkvplhtvikl

TPIPYGNRIEVFDLGV
||..||...|...| |
tpvaYgckvellkldv
0036777 Phosphoglycerate mutase-like 300-503 8.3e-43 139.1 In-house 3-226 (247) alignment 
Range on Protein: 300-503
Range on HMM: 3-226/247.0
RHIYISRHGESMYNTKGLIGG--DSDLSPRGRLYARRLRNFMAKFvSWRSDgdgdgddtngekldnlRVWCSSLNRTIQTVEHF--------RYKEAWKA
...|. ||||...|. |.. |  |..|...|| .|..|. ....   .. |                .|..| | |.||| |..           . ...
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkel.glpfd................avysSpllRAiqTaeiilealglsllpvvvdpr

LDELDAGECDGLSYEETKERFPEMYKERQGNKYWTRY-------------------------PRGESYADVVQRLEPRIMELERM----RDNVLVVCHQA
| |.| |...||...|..|..||..  .. ..|..|.                         | |||.||||.|..| ..|| .      .|||||.|..
LrErdyGalegltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHgg

VARCLLAYFQNMSdlADQLPYLKIPLHTVFKITPIPYGNRIEV
| |.||||. ..|   .....|..| .......  ..|... .
vlrallayllgls..ledilrlnlpngsitvleldddgklwvl
0053607 Phosphoglycerate mutase-like 300-503 3.1e-42 136.6 In-house 2-186 (191) alignment 
Range on Protein: 300-503
Range on HMM: 2-186/191.0
RHIYISRHGESMYNTKGLIGGDSDLSPRGRLYARRLRNFMAKFvswrsdgdgdgddtngeKLDNLRVWCSSLNRTIQTVEHFRYK-EAWKALDELDAGEC
...|. ||||...|..|.. ||..|...|| .||.| ...|..                  |.  .|..| | |..|| |.. .. | ...| |.|.|..
trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellael.................glkfdavysSpllRarqTaeiiglpvevdprlrEidfgdw

DGLSYEETKERFPEMYKERQGNKYWTRYPRGESYADVVQRLEPRIMELERmRDNVLVVCHQAVARCLLAYFQNMSdlADQLPYLKIPLHTVFKITPIPYG
.||..||..|..||..  .. .....|.|.|||.|||..|..| ..|| .  .|||||.|..| |.||||. ...   ..|..|..| ..|..... ..|
egltleelaekypeelaawlrdpldyrppggEsladvaaRvlpaleella.ggnvlvVaHggvirallayllglp..leellrlnlpngsvtvlelddgg

NRIEV
 ....
wvlvl
0051064 Phosphoglycerate mutase-like 300-506 6e-42 136.5 In-house 4-230 (241) alignment 
Range on Protein: 300-506
Range on HMM: 4-230/241.0
RHIYISRHGESMYNTKGLIGG--DSDLSPRGRLYARRLRNFMAKFvSW--RsdgdgdgddtngekldnlRVWCSSLNRTIQTVEHF--------RYKEAW
...|. |||||..|. |.. |  |..|...|| .||.|....|..  .                     .|..| | |.||| |..           . .
krlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladl.gikfd..................avysSpllRaiqTaeiiaealglpllpvvvd

KALDELDAGECDGLSYEETKERFPEMYKERQGNKYWTRY-------------------------PRGESYADVVQRLEPRIMELERM----RDNVLVVCH
..| |.| | ..||..||..|.||| .  .  .....|.                         |.|||.|||..|..| . || ..     .|||||.|
prlrEidfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsH

QAVARCLLAYFQNMSdlADQLPYLKIPLHTVFKITPIPYGNRIEVFDL
..| |.||||. ...   ..|..|..| ..|....  ..|.|. .  |
ggvirallayllglp..leellrlnlpngsvtvleldddgkrvvlvll
0049178 Phosphoglycerate mutase-like 300-504 7.7e-42 135.9 In-house 4-226 (243) alignment 
Range on Protein: 300-504
Range on HMM: 4-226/243.0
RHIYISRHGESMYNTKGLIGG--DSDLSPRGRLYARRLRNFMAKFvSWRSDgdgdgddtngekldnlRVWCSSLNRTIQTVEHF--------RYKEAWKA
...|. ||||...|..|.. |  ||.|...||  ||.|....|.   .. |                .|..| | |.||| |..           . ...
trlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellael.glkfd................avysSplkRaiqTaeiilealglpllpvvvdpr

LDELDAGECDGLSYEETKERFPEMYKERQGNKYWTRY-----------------------PRGESYADVVQRLEPRIMELERM----RDNVLVVCHQAVA
| |.| |...||...|.....||..  .. ..|..|.                       | |||.|||..|..| ..|| .      ..||||.|..| 
LrErdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvi

RCLLAYFQNMSDlaDQLPYLKIPLHTVFKITPIPYGNRIEVF
|.|||.. ....  ..|..|..| ..|....  ..| ... .
rallalllglpl..eellrlnlpngsvtvlelddggwvlvsl
0043909 Phosphoglycerate mutase-like 300-502 1.4e-41 134.9 In-house 3-232 (249) alignment 
Range on Protein: 300-502
Range on HMM: 3-232/249.0
RHIYISRHGESMYNTKGLIGG--DSDLSPRGRLYARRLRNFMAKFvSWRSDgdgdgddtngekldnlRVWCSSLNRTIQTVEHF--------RYKEAWKA
...|. ||||...|..|.. |  ||.|...||  ||.|......   .. |                .|..| | |.||| |..           | ...
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkel.gipfd................avysSplkRAiqTaeiileelgldklpvevdpr

LDELDAGECDGLSYEETKERFPEMYKERQG-----------------------------NKYWTRYPRGESYADVVQRLEPRIMELERM----RDNVLVV
| |.| |...||...|..|..|| .  ..                              .... |.|.|||.||||.|..| ..|| ..     .|||.|
LrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliV

CHQAVARCLLAYFQNMSdlADQLPYLKIPLHTVFKITPIPYGN---RIE
.|..| |.||||. ..|   .....|..| ........ ..|.   ...
aHggvlrallayllgls..ledilrlnlpngsitvlelddggkpvvvlv
0036887 Phosphoglycerate mutase-like 300-497 3.8e-40 130.0 In-house 2-188 (202) alignment 
Range on Protein: 300-497
Range on HMM: 2-188/202.0
RHIYISRHGESMYNTKGLIGG--DSDLSPRGRLYARRLRNFMAKFvswrsdgdgdgddtngeklDNLRVWCSSLNRTIQTVEHFRYK-----EAWKALDE
...|. ||||...|..|.. |  |..|...|| .||.| ...|..                   .  .|..| | |.|||.|..        . ...| |
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerlagl...................pfdavysSpllRaiqTaeiiaealglpvivdprlrE

LDAGECDGLSYEETKERFPEMYKERQGNKYWTRYPRGESYADVVQRLEPRIMELERMR--DNVLVVCHQAVARCLLAYFQNMSdlADQLPYLK-IPLHTV
.| | ..||..||..|..||... .. ..|..|.|.|||.||||.|... ..|| ..   .|||||.|..| |.||||. ..|   ..|..|. .| ..|
idfgalegltleeiaekypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllgls..ledllrlrklpngsv

FKITPIPY
....  ..
tvlelddg
0039931 Phosphoglycerate mutase-like 301-506 5.8e-48 155.4 In-house 1-187 (219) alignment 
Range on Protein: 301-506
Range on HMM: 1-187/219.0
HIYISRHGESMYNTKGLIGGDSDLSPRGRLYARRLRNFMAKF-V-SwrsdgdgdgddtngekldnLRVWCSSLNRTIQTVEHFRYK-EAWKALDELDAGE
..|. ||||...|..|.. |||.|..||| .||.| .....  .                      .|..| | |.||| |.. .. | ...| |.|.| 
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpf...................davysSpllRaiqTaeiiglpveidprLrEidfgd

CDGLSYEETKERFPEMYKERQGNKYWTRYPRGESYADVVQRLEPRIMELERmRDNVLVVCHQAVARCLLAYFQNMSdlADQLPYLKIPLHTVFKITPIPY
..||..||..|..||..  .. ..|..|.|.|||.||||.|..| ..||..  .|||||.|..| |.||||. ..|   .....|..| ..| .... ..
legltleeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleella.genvlvVsHggvirallayllgls..leeilrlnlpngsvtvlelddg

GNRIEVFDL
|.... ..|
gwvlvllnl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 301-465 6.7e-33 106.8 Pfam-A 1-158 (158) alignment 
Range on Protein: 301-465
Range on HMM: 1-158/158.0
HIYISRHGESMYNTKGLIGGDSD--LSPRGRLYARRLRNFMAKfvswrsdgdgdgddtngEKLDNLRVWCSSLNRTIQTVEHFRYKEAW-----KALDEL
..|. ||||| .|..| . |.||  |...||  ||.| . ...                 ..|   .|..| | |.|||.| .. .        ..| |.
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr.................adlpidavytSplkRaiqTaeilleeldipiikeprLrer

DAGECDGLSYEETKERFPEMYKERQGNKYWTRYPRGESYADVVQRLEPRIMELE---RMRDNVLVVCHQAVARCL
|.||..||..||.||.||| |.... .|.  |.|.|||.|||..|..| ..||    .  .|||.|.|..| |.|
dfgeweglpkeevkeefpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 301-465 6.7e-33 106.8 In-house 1-158 (158) alignment 
Range on Protein: 301-465
Range on HMM: 1-158/158.0
HIYISRHGESMYNTKGLIGGDSD--LSPRGRLYARRLRNFMAKfvswrsdgdgdgddtngEKLDNLRVWCSSLNRTIQTVEHFRYKEAW-----KALDEL
..|. ||||| .|..| . |.||  |...||  ||.| . ...                 ..|   .|..| | |.|||.| .. .        ..| |.
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr.................adlpidavytSplkRaiqTaeilleeldipiikeprLrer

DAGECDGLSYEETKERFPEMYKERQGNKYWTRYPRGESYADVVQRLEPRIMELE---RMRDNVLVVCHQAVARCL
|.||..||..||.||.||| |.... .|.  |.|.|||.|||..|..| ..||    .  .|||.|.|..| |.|
dfgeweglpkeevkeefpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
0035570 Phosphoglycerate mutase-like 302-508 3.3e-47 153.0 In-house 2-189 (219) alignment 
Range on Protein: 302-508
Range on HMM: 2-189/219.0
IYISRHGESMYNTKGLIGGDSDLSPRGRLYARRLRNFMAKFVswrsdgdgdgddtngekLDNLRVWCSSLNRTIQTVEHFRYK-EAWKALDELDAGECDG
.|. ||||...|..|.. ||..|..||| .||.| ...|.                   ..  .|..| | |.||| |.. .. | ...| |.|.|...|
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlg.................ipfdavysSpllRaiqTaeiiglpveidprLrEidfgdleg

LSYEETKERFPEMYKERQGNKYWTRYPRGESYADVVQRLEPRIMELERmRDNVLVVCHQAVARCLLAYFQNMSdlADQLPYLKIPLHTVFKITPIPYGNR
|...|..|..|| .. .. ..|..|.|.|||.||||.|..| ..|||.  .|||||.|..| |.||||. ...  ......|..| ..| .... ..|..
ltldeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleeled.genvlvVsHggvirallayllglp..leeilrlnlpngsvtvleldggggk

IEVFDLGV
...  |. 
wvlvllnd
0048955 Phosphoglycerate mutase-like 302-499 5.2e-40 130.2 In-house 3-220 (240) alignment 
Range on Protein: 302-499
Range on HMM: 3-220/240.0
IYISRHGESMYNTKGLIGG--DSDLSPRGRLYARRLRNFMAKFvswR---SdgdgdgddtngekldnlRVWCSSLNRTIQTVEHF--------RYKEAWK
.|. |||||..|..|.. |  |..|...|| .||.|....|.        .                 .|..| | |.||| |..           . . 
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadl...gikfd.................lvysSpllRaiqTaeiiaealglpllpvvvdp

ALDELDAGECDGLSYEETKERFPEMYKERQGNKYWTRY-------------------------PRGESYADVVQRLEPRIMELER----MRDNVLVVCHQ
.| |.| | ..||...|..|.||| .  .  .....|.                         |.|||.|||..|... . || .      .|||||.|.
rlrErdfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHg

AVARCLLAYFQNMSdlADQLPYLKIPLHTVFKITPIPYGN
.| |.||||. ...   .....|.|| . |....  ....
gvirallayllglp..leeilrlnipngsvtvlelddglv
0050036 Phosphoglycerate mutase-like 302-475 1.4e-33 107.9 In-house 3-150 (171) alignment 
Range on Protein: 302-475
Range on HMM: 3-150/171.0
IYISRHGESMYNTKGLIGG--DSDLSPRGRLYARRLRNFMakfvswrsdgdgdgddtngeklDNLRVWCSSLNRTIQTVEHFRYK-EAWKALDELDAGEC
.|. ||||...|..|.. |  |..|...|| .||.|....                      .  .|..| | |..|| |.. .. . ...| |.| |..
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell......................pfdavysSpllRArqTaelillpvivdprLrErdfGaw

DGLSYEETKERFPEmykeRQGNKYWTRYPRGESYADVVQRLEPRIMELErmrDNVLVVCHQAVARCLLAYFQNMSDL
.||...|.....||    .  .... ..| |||.|||..|. | . ||    .|||||.|..| |.|||.. ..|. 
egltldeiaakype....wlldlldlappggEsladvlaRvlpaleell...gnvlvvaHggvirallalllglsle
subfamily_TIGAR_pd Subfamily TIGAR 302-472 1e-06 20.6 In-house 3-176 (222) alignment 
Range on Protein: 302-472
Range on HMM: 3-176/222.0
IYISRHGESMYNTKGLIGGDS--DLSPRGRLYARRLRNFMAKfvswrsdgdgdgddtngEKLDnlRVWCSSLNRTIQTVEHFRY----KEAW-----KAL
... ||||...| .... | .   ||..|.  | |. ....                  ||..  ..  | | |. ||.|  .     |.       | |
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsn.................ekin..yifsSdllRAkqTaeiilkalkekkreaverdkrL

DELDAGECDGLSYEETKERFPEMYkerqgnKYWTRYP-RGESYADVVQRLEPRIMEL-------E---------RMRDNVLVVCHQAVARCLLAYFQNM
 | . |.  | ...| .|    .       . .   |  ||| . . .|| . . ||       |         .   .||||.|... | ||...  .
rEreyGvyeGvaldelrellkaag......nvpsfvpegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlhve
subfamily_PGAM_pd Subfamily PGAM 404-475 1.4e-06 19.8 In-house 124-200 (248) alignment 
Range on Protein: 404-475
Range on HMM: 124-200/248.0
EETKERFPEMYKERQ-GNKYWTRYPRGESYADVVQRLEPRIME----LERMRDNVLVVCHQAVARCLLAYFQNMSDL
|| || | |..|.|.  ..   ..|. || ..||.||.| . |      .   .||.| |  . |.|| . ...|| 
eedkeyfkeinkdrryeelkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisde