Gene PGAM in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PGAM
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP114_AA protein Get Run
MbreP114_AA_0-238 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049178 Phosphoglycerate mutase-like 1-235 2.5e-69 225.7 In-house 1-233 (243) alignment 
Range on Protein: 1-235
Range on HMM: 1-233/243.0
MAKYQVVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDQEFIPVVKDYRLNERMYGALAGLDK
| ......||||...||.|....||.|.||.|.|. .|...|. |.|.|.||| ...| |||||.|..||||. .....|||.| ||.|| .||| || |
mmmtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltk

KETVEKHGAEQVHIWRRSYDIPPPACEKDHPYHPSKSPWAASIpeDKLPATESLKLTLERVLPYWDEVIVPEIKAGKKVLIAAHGNSIRAILKYLDDISE
.|. .|.. |.|..||..||..||| . .....|   .. |..  | ||  |||. ...||||...|.. . ...|| ||. |||..|||.|..| ... 
aeiaakypeelvawwrdpydarppalllldlllplldrlladl..dllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpl

EVIPALDVPTGVPLFYEFDENMKPIKQEGAAEHLS
| .. |..|.| .. .|.|...  ..  .   ||.
eellrlnlpngsvtvlelddggwvlvslndtshld
0051064 Phosphoglycerate mutase-like 1-225 1.3e-66 217.1 In-house 1-225 (241) alignment 
Range on Protein: 1-225
Range on HMM: 1-225/241.0
MAKYQVVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDQEFIPVVKDYRLNERMYGALAGLDK
|. .....||||.|.||.|....|| ||||.|.|. .|...|. |...|.||| ...| |.||| |..||.|. .....||| | ||.|. .||| || .
mmmkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltl

KETVEKHGAEQVHIWRRSYDIPPPACEKDHPYHPSKSPWAASIPEDKLPATESLKLTLERVLPYWDEVIVPEIKAGKKVLIAAHGNSIRAILKYLDDISE
.|. ||.. |.|...|...|..|| .| ......  ... |....| ||  |||. . .||||...|.. . ...|| ||. .||..|||.|.|| ... 
eeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglpl

EVIPALDVPTGVPLFYEFDENMKPI
| .. |..|.| .. .|.|...|..
eellrlnlpngsvtvleldddgkrv
subfamily_PFKFB_pd Subfamily PFKFB 2-125 4.5e-14 44.3 In-house 5-119 (198) alignment 
Range on Protein: 2-125
Range on HMM: 5-119/198.0
AKYQVVFVRHGQSQWNLENKFTGwvDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIIleesdqeFIPVVKDYRLNERMYGALAGLDKK
.......||||.|..| ... .|  |  |.|.||  ||...  .||.  |  . .|| |||.|.| ...        .|. .   |.|.  | ..||  .
kpreiylvRhGeseknkkgrigg..dseLterGveyakklakfikeenlkelrvwtselkrtiqTaell.......glpkeqwkaLdeldaGkcdgltye

ETVEKHGAEQVHIWRRSYDIPPPA
|. ||.. |  .  . .|   .| 
eikekfpeefkerkkdkyryrypr
0037864 Phosphoglycerate mutase-like 3-225 1.1e-59 193.6 In-house 7-204 (211) alignment 
Range on Protein: 3-225
Range on HMM: 7-204/211.0
KYQVVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDQEFIPVVKDYRLNERMYGALAGLDKKE
 .....||||...||.|....||.||||.|.|. .|...|. |...|..|| ...| |.|||.|..||||. .....||. | ||.|| .||| || ..|
mtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgalegltlee

TVEKHGAEQVHIWRRSYDIPPPACekdhpyhpskspwaasipedklpatESLKLTLERVLPYWDEVIVPEIKAGKKVLIAAHGNSIRAILKYLDDISEEV
. ||...|.|...|..||..|| .                         |||. ...||||...|.. . .| |. ||. .||...||.|.|| ..| | 
iaekypeelvawlrdpydfrppgg.........................EsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglslee

IPALDVPTGVPLFYEFDENMKPI
.. | .|.| .. .|.|.. ...
llrlnlpngsvtvlelddggwvl
subfamily_PGAM_pd Subfamily PGAM 4-256 1.9e-105 343.6 In-house 1-247 (248) alignment 
Range on Protein: 4-256
Range on HMM: 1-247/248.0
YQVVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDQEFIPVVKDYRLNERMYGALAGLDKKET
...|..|||.|..| ||||.||||. |||.|. |||.|| .||.....|| ..|||||||..|...||||.|||.|||.|..|||||.||||.||.|.|.
iklvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltglnkaev

VEKHGAEQVHIWRRSYDIPPPACEKDHPYHPS--KSPWAASIPEDKLPATESLKLTLERVLPYWDEVIVPEIKAGKKVLIAAHGNSIRAILKYLDDISEE
..|.| |.|.|||||||..||..|.|..|. .  |... ....|..||..|||| ..||.||...|.|..|||.||.|||.|||||.||.||.|..||.|
akkyGeekvkiwRRsydvkPPpveedkeyfkeinkdrryeelkeeelPesEslkevveRllpvlneeilkeikegkrvlivahgnsvrallkvlegisde

VIPALDVPTGVPLFYEFDENMKPIKQEgaaehlsgRYLIDEETLKAKIEEVKNQT
.| .||.|||.||.||.|||.||.|..        ..| |||..|...|.|.|| 
aikeldlptgiplvyeldenlkpvkkk........qflgDeesvkkaaeavanqg
0043909 Phosphoglycerate mutase-like 4-227 6.6e-71 230.8 In-house 3-233 (249) alignment 
Range on Protein: 4-227
Range on HMM: 3-233/249.0
YQVVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDQEFIPVVKDYRLNERMYGALAGLDKKET
.....||||...||.|..|.||.|.||.|.|. .|...|. |||.|..|| ...| |||||.|..||||| .....||..| ||.|| .||| ||.|.|.
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaei

VEKHGAEQVHIWRRSYDIPPPACEKDHPYHPSKSPWAA----SIPEDKLPATESLKLTLERVLPYWDEVIVPEIKAGKKVLIAAHGNSIRAILKYLDDIS
 ||.. |.|...|||||..||..|.......  ... |     .. | .| .|||. ...||||...|.. . .| |. ||| |||...||.|.|| ..|
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgls

EEVIPALDVPTGVPLFYEFDENMK---PIKQ
 | |. | .|.| .. .|.|.. |    .. 
ledilrlnlpngsitvlelddggkpvvvlvl
0036777 Phosphoglycerate mutase-like 5-225 5.3e-71 231.2 In-house 4-224 (247) alignment 
Range on Protein: 5-225
Range on HMM: 4-224/247.0
QVVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDQEFIPVVKDYRLNERMYGALAGLDKKETV
....||||...||.|..|.||.||||.|.|. .||..|. |||.|..|| ...| |.|||.|..||||. .....|||.| ||.|| |||| ||.|.|. 
rlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaeia

EKHGAEQVHIWRRSYDIPPPACEKDHPYHPSKSPWAASIPEDKLPATESLKLTLERVLPYWDEVIVPEIKAGKKVLIAAHGNSIRAILKYLDDISEEVIP
||...|.|..||..||..||  |......... .. | .| |.||  |||. ...||||...|.. . .| |. ||. .||...||.|.|| ..| | |.
ekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsledil

ALDVPTGVPLFYEFDENMKPI
 | .|.| .. .|.|.. |..
rlnlpngsitvleldddgklw
0048955 Phosphoglycerate mutase-like 5-228 2.6e-66 216.0 In-house 2-222 (240) alignment 
Range on Protein: 5-228
Range on HMM: 2-222/240.0
QVVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDQEFIPVVKDYRLNERMYGALAGLDKKETV
....||||.|.||.|....|| ||||.|.|. .|...|. |...|.||| ...| |.||| |..||.|. .....||| | ||.|| .||| || ..|. 
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia

EKHGAEQVHIWRRSYDIPPPACEKDHPYHPSKSPWAASIPEDKLPATESLKLTLERVLPYWDEVIVPEIKAGKKVLIAAHGNSIRAILKYLDDISEEVIP
||.. |.|...|...|..|| .| .......  .. |...|| ||  |||. . .|||....|.. . .|.|| ||. .||..|||.|.|| ... | |.
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeil

ALDVPTGVPLFYEFDENmkpIKQE
 |..|.| .. .|.|..   ..  
rlnipngsvtvlelddg...lvsl
0035570 Phosphoglycerate mutase-like 5-222 1.2e-52 170.8 In-house 1-179 (219) alignment 
Range on Protein: 5-222
Range on HMM: 1-179/219.0
QVVFVRHGQSQWNLENKFTGwvDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIIleesdqeFIPVVKDYRLNERMYGALAGLDKKETV
....||||...||||....|  ||||.|.|. .|...|. |...|..|| ...| |.|||.|..||        .||. | ||.|. .|.| ||...|. 
rlyLvRHGetewnlegrlqg..dvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltldeia

EKHGAEQVHIWRRSYDIPPpacekdhpyhpskspwaasipedklPATESLKLTLERVLPYWDEVivpeiKAGKKVLIAAHGNSIRAILKYLDDISEEVIP
||.. |.....|..||..|                         |  |||. . .||||...|.     . |. ||. .||..|||.|.|| ... | |.
ekypeelaawlrdpydyrp.........................pggEsladvvaRvlpaleel.....edgenvlvVsHggvirallayllglpleeil

ALDVPTGVPLFYEFDENM
 |..|.| .. .|.|.. 
rlnlpngsvtvleldggg
0039931 Phosphoglycerate mutase-like 5-238 1.7e-52 170.2 In-house 1-195 (219) alignment 
Range on Protein: 5-238
Range on HMM: 1-195/219.0
QVVFVRHGQSQWNLENKFTGwvDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIIleesdqeFIPVVKDYRLNERMYGALAGLDKKETV
....||||...||.|....|  |.||.|.|. .|...|. ||..|..|| ...| |.|||.|..||        .||. | ||.|. .|.| ||...|. 
rlyLvRHGetewnvegrlqg..dspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.......glpveidprLrEidfgdlegltleeia

EKHGAEQVHIWRRSYDIPPpacekdhpyhpskspwaasipedklPATESLKLTLERVLPYWDEViVPeikaGKKVLIAAHGNSIRAILKYLDDISEEVIP
||.. |.....|..||..|                         |  |||. . .||||...|. ..    |. ||. .||..|||.|.|| ..| | |.
ekypeelaawlrdpydyrp.........................pggEsladvvaRvlpaleel.la....genvlvVsHggvirallayllglsleeil

ALDVPTGVPLFYEFDENMKPIKQEGAAEHLSGRY
 |..|.| .. .|.|..   ..  .  .||.. .
rlnlpngsvtvlelddggwvlvllnltshlddll
0036887 Phosphoglycerate mutase-like 5-231 3.9e-51 165.7 In-house 3-198 (202) alignment 
Range on Protein: 5-231
Range on HMM: 3-198/202.0
QVVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKeqGFKFDEAFTSVLKRAIKTCNIILEESDqefIPVVKDYRLNERMYGALAGLDKKETV
....||||...||.|....|..||||.|.|. .|...|. |.  |..|| ...| |.|||.|..||.|. .   .||. | ||.|. .||| || ..|. 
rlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealg...lpvivdprlrEidfgalegltleeia

EKHGAEQVHIWRRSYDIPPPACekdhpyhpskspwaasipedklpatESLKLTLERVLPYWDEVIVPEikAGKKVLIAAHGNSIRAILKYLDDISEEVIP
||...|.....|..||..||                           |||. ...|||....|.. .   .|. ||. .||...||.|.|| ..| | ..
ekypeelaawlrdpydfrppgg.........................EsladvvaRvlaaleellarl..dggnvlvVsHggvlrallayllglsledll

ALD-VPTGVPLFYEFDENMKPIKQEGAA
 |. .|.| .. .|.|..   ..  .  
rlrklpngsvtvlelddggwvlvllndt
0050036 Phosphoglycerate mutase-like 5-220 7.3e-50 160.7 In-house 2-169 (171) alignment 
Range on Protein: 5-220
Range on HMM: 2-169/171.0
QVVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLkeqgfKFDEAFTSVLKRAIKTCNIILeesdqefIPVVKDYRLNERMYGALAGLDKKETV
....||||...||||..|.||.||||.|.|. .|. .|. |     .|| ...| |.||..|...||       .||..| ||.|| .||. ||...|. 
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.......lpvivdprLrErdfGawegltldeia

EKHGAeqvhiwrrsydipppacekdhpyhpskspWAASIPEDKLPATESLKLTLERVLPYWDEVIvpeikagKKVLIAAHGNSIRAILKYLDDISEEVIP
.|..                              | . .. . .| .|||. .|.||||...|..       . ||..|||..|||.|..| ..| | |.
akype.............................wlldlldlappggEsladvlaRvlpaleell.......gnvlvvaHggvirallalllglsleeil

ALDVPTGVPLFYEFDE
 |..|.|..| .|.|.
rlelpngsvlvleldd
0053607 Phosphoglycerate mutase-like 5-224 2.4e-49 159.7 In-house 3-183 (191) alignment 
Range on Protein: 5-224
Range on HMM: 3-183/191.0
QVVFVRHGQSQWNLENKFTGwvDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIIleesdqeFIPVVKDYRLNERMYGALAGLDKKETV
....||||...||.|....|  ||||.|.|. .|. ... |.|.|.||| ...| |.||..|..||        .||. | ||.|. .|.. || ..|. 
rlyLvRHGetewnaegrlqg..dvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.......glpvevdprlrEidfgdwegltleela

EKHGAEQVHIWRRSYDIPPpacekdhpyhpskspwaasipedklPATESLKLTLERVLPYWDEVIVpeikaGKKVLIAAHGNSIRAILKYLDDISEEVIP
||.. |.....|...|..|                         |  |||. ...||||...|..      |. ||. |||..|||.|.|| ... | ..
ekypeelaawlrdpldyrp.........................pggEsladvaaRvlpaleella.....ggnvlvVaHggvirallayllglpleell

ALDVPTGVPLFYEFDENMKP
 |..|.| .. .|.|..   
rlnlpngsvtvlelddggwv
subfamily_PGAM5_pd Subfamily PGAM5 5-77 3.9e-08 24.7 In-house 3-70 (189) alignment 
Range on Protein: 5-77
Range on HMM: 3-70/189.0
QVVFVRHGQSQWNLENKftgwvDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDQE
....||||| . . ...     .  |.| |   |.. |  ||| ..||..  .| . ||. |..||... ...
hlilvrhgqyvldddsd.....kkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdv
His_Phos_1 Histidine phosphatase superfamily (branch 1) 6-191 8e-44 142.3 Pfam-A 2-158 (158) alignment 
Range on Protein: 6-191
Range on HMM: 2-158/158.0
VVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDqefIPVVKDYRLNERMYGALAGLDKKETVE
...||||.|.|| |....|| ||||.|.|  .|.|.|. ||... ..| ..|| |||||.|..|.||| |   ||. |. ||.||..|.. ||.|.|. |
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevke

KHGAEQVHIWRRSYDIPPPacekdhpyhpskspwaasipedklpATESLKLTLERVLPYWDEVIVpEIKAGKKVLIAAHGNSIRAI
....|. ...|..... ||                           |||. . ||| |...|.|  . . |..||| .||...||.
efpeeyekwkrdkkefrpp.........................egesladvyeRvapfleelie.akdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 6-191 8e-44 142.3 In-house 2-158 (158) alignment 
Range on Protein: 6-191
Range on HMM: 2-158/158.0
VVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDqefIPVVKDYRLNERMYGALAGLDKKETVE
...||||.|.|| |....|| ||||.|.|  .|.|.|. ||... ..| ..|| |||||.|..|.||| |   ||. |. ||.||..|.. ||.|.|. |
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeld...ipiikeprLrerdfgeweglpkeevke

KHGAEQVHIWRRSYDIPPPacekdhpyhpskspwaasipedklpATESLKLTLERVLPYWDEVIVpEIKAGKKVLIAAHGNSIRAI
....|. ...|..... ||                           |||. . ||| |...|.|  . . |..||| .||...||.
efpeeyekwkrdkkefrpp.........................egesladvyeRvapfleelie.akdkgenvlivsHggvlral
subfamily_TIGAR_pd Subfamily TIGAR 6-110 7.3e-24 76.7 In-house 3-106 (222) alignment 
Range on Protein: 6-110
Range on HMM: 3-106/222.0
VVFVRHGQSQWNLENKFTGWVDVPLSEQGVIEAKEAGAVLKEqgFKFDEAFTSVLKRAIKTCNIILEESDQE-FIPVVKDYRLNERMYGALAGLDKKETV
.. ||||....| |. ..| .| ||||.||  || ..  |..   |.. .|.| |.|| .| .|||... ..   .|..| || || || . | ...|  
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsn..ekinyifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldelr

EKHGAE
|   |.
ellkaa
subfamily_TFC7_pd Subfamily TFC7 26-89 1.2e-08 25.8 In-house 29-89 (255) alignment 
Range on Protein: 26-89
Range on HMM: 29-89/255.0
VDVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDqefIPVVKDYRLNE
 ||||||.||  ||| .  ||. . | . .|.| |.| ..| . | || .   |||  |. . |
sdvPlserGveqakelaiylkkldlkpeaifssPlyrcletskpiaeele...iPvyvdrGvge
subfamily_STS_pd Subfamily STS 27-92 1.1e-10 33.3 In-house 52-116 (245) alignment 
Range on Protein: 27-92
Range on HMM: 52-116/245.0
DVPLSEQGVIEAKEAGAVLKEQGFKFDEAFTSVLKRAIKTCNIILEESDqEFIPVVKDYRLNERMY
|.||.| ||| ||. |  | |.| | ...| |   | | |.. ||.. . . |..  .. | | ..
DpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg.kkikikvepgllewlk