Gene ILKAP in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily ILKAP
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP123_AA protein Get Run
MbreP123_AA_17-321 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 18-321 2.3e-62 203.4 In-house 17-290 (295) alignment 
Range on Protein: 18-321
Range on HMM: 17-290/295.0
QPSRFFAGHAERRGAREAIEDVCVVQEQLDLQRQacarisSAAYFACFDGHAGRRAADHCAEHMLPHILAHLPSLsDFGSKECATKIRKSLGQAFAAEDR
.. .. .|.|  .| |.  || ..|  .|  . .      . ..|. |||| | .||....|... ..| .| .| .. . .  . |...| .|| | |.
lllllrvgvasdqGrrksneDavlvvlnllslle......dlllfgvfDGhgGhaaaevasellvelllellekl.lllltlsledieealrkaflaade

EFLALARAGQPQWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEAptvadtesvlpmlvdqdiatLVLTKDHNPVVYEERQRIQKAGGSVTDNRVQGV
|.|.||..    .  |.||.|.|  .. |..||||| .|.|.| .|.                    . ||.||.|| ..||.||..||| |...|| ||
ellelallrpelagsGtTavvalirgnklyvanvGDSravllrngel....................vqltvdhkpvnelererilsaggavshgrvngv

LGVSRSIGDGRYK--------HLGVSSQPFTSKCTLDPNKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEQddqlagqpklqATHVAARLANHAVEKG
| |.|..|| ..|        . .||. | ..  .|....| ||.||.||||..|| ......... . .              ....| .|...|...|
lavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld...........leeaaeeLvdlAlarg

ASDNVSVLLVRF
..||..|..||.
srDNiTvvvvrl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 19-322 2.6e-37 121.5 In-house 3-254 (255) alignment 
Range on Protein: 19-322
Range on HMM: 3-254/255.0
PSRFFAGHAERRGAREAIEDVCVVQEQLDLQrqacariSSAAYFACFDGHAGRRAADHCAEHmLPHILAHLPSLSDFgskecatKIRKSLGQAFAAEDRE
 |||  |...  | | ..||  |.  .   .       |   |.| ||||.||.||....|. |..|||.|  | .        .  ||| .|. . .  
ssrfkvgfsdmiGrrptmedelviyGsfrdk.......sdedyyalfdGhgGraaakfasee.lykilaelldlnna.......nPvkslkkaykeistq

FlalarAGQPqWKDGCTATVCLALNDVLFTANVGDAKAILVrykeaptvadtesvlpmlvDQDIATLVLTKDHNPVVYEERQRIQKAGGSVTDN----RV
.     . .|    |.||.. | ..|  . |||||....|                    ..|  .  |. ||.|.  .|..||...|| |  .    ||
i.....serp.kfiGttaasvliiedkvyianvGdsrvvlc...................qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrv

QGVLGVSRSIGDGrYKHLGVSSQPFTSKCTLDPNKDLFLVLACDGLWGTLSASDVIQFCMKAfgeAEQDdqlagqpklqatHVAARLANHAVEKGASDNV
 | | |||..||  . .  | ..|  |.     .|| ||.|||||.|  .|  . ..  ..    .. .            . | .| ..| ..|..||.
nGtlavsralGds.flePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagi...sdpe............kaaeklrdlayssGstdni

SVLLVRFA
||......
svivikls
subfamily_ILKAP_pd Subfamily ILKAP 20-321 1.4e-126 414.5 In-house 3-292 (293) alignment 
Range on Protein: 20-321
Range on HMM: 3-292/293.0
SRFFAGHAERRGAREAIEDVCVVQEQLDLQ-RQACARISSAAYFACFDGHAGRRAADHCAEHMLPHILAHLPSlSDFGSKEcaTKIRKSLGQAFAAEDRE
..... .|||.|.||...|..|..|.|| | |......|...|.|.||||||.||....||..  .||..||. ||. .||  ..|.|.| ..|...|.|
yklkgayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsake..keikkclvdsfkktdee

FLALARAGQPQWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEAPTVadtesvlpmlvdqdIATLVLTKDHNPVVYEERQRIQKAGGSVTDNRVQGVL
||.||....|.||||.||||.|.|..||..||.||.||.|||.||....              ||..||||||.|| ||||.|||||||.|.|.||.|||
fLklaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdk..............iasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvl

GVSRSIGDGRYKHLGVSSQPFTSKCTLDPNkDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEQDDQLAGQPKLQATHV-----AARLANHAVEKGASDN
.|||||||||.|.|||.|.|...||.|..| |||.|||||||| ..||..|..|..|.....|.|.......|.....|     ..|||..||..|.|||
evsrsiGdgrfkrlGvistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdn

VSVLLVRF
|.||||..
vtvllvki
subfamily_PPM1A_pd Subfamily PPM1A 24-164 9.7e-21 67.3 In-house 14-147 (282) alignment 
Range on Protein: 24-164
Range on HMM: 14-147/282.0
AGHAERRGAREAIEDVCVVQEQLDlQrqacarISSAAYFACFDGHAGRRAADHCAEHMLPHILAHLPSLSDFGSKECATKIRKSLGQAFAAEDREFLALA
.| .. .| |   ||  .|. .|  .      ... ..|| ||||||...|.....|.| .|| .    .   ... . .... | |.| | | .  .| 
ygvssmqgwrvemEDahtvvaslg.a......lkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairels

RAGQPQWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEA
.  . . | |.||...|  .. |..||.||..|.|.| ..|
tdlktadksGsTavtvlvsekhliianlGDsRavlcrngka
PP2Cc_SM00332 25-319 4.6e-53 173.4 In-house 13-274 (274) alignment 
Range on Protein: 25-319
Range on HMM: 13-274/274.0
GHAERRGAREAIEDVCVVQEQLDlqrqacaRISSAAYFACFDGHAGRRAADHCAEHMLPHILAHLPSLSDFGskecATKIRKSLGQAFAAEDREFLALAR
| ..  |.|...||..||. .|.         .....|. ||||.| ..|. .....  ..  .| . .|        .. . | .|| . | |.|. ..
gkssmqgwrksmeDahvvvvdlv.......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel....eddveealkkaflstdeeileeeq

AGQPQ-WKDGCTATVCLALNDVLFTANVGDAKAILVRYKEaptvadtesvlpmlvdqdiaTLVLTKDHNPVVYEERQRIQKAGGSVTDNRVQGVLGVSRS
  ... .. |.||.|.|  .. |. ||||| .|.|.| ..                     . |..||.| . .||.||.||||.| ..||.|.| |||.
skelenalsGstavvallkkedlyvanvGDSravlcrngk....................avqlsvdhkpedederkRikkaggvvekgrvngglavsra

IGDGRYK------HLGVSSQPFTSKCTLdPNKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAeqddqlagqPKLQATHVAARLANHAVEK-GASDNVSV
.||. .|        .....| .. .||  ..| ||.||.||||  ||  .|.....|   .           . ... .|..|...| .. |..||..|
fGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg.........ktndpqeaaelldeeairrggseDniTv

LLV
..|
vvv
0049733 PP2C-like 25-321 5.6e-44 143.2 In-house 6-233 (235) alignment 
Range on Protein: 25-321
Range on HMM: 6-233/235.0
GHAERRGA-REAIEDVCVVqeqldlqrqacarisSAAYFACFDGHAGRRAADHCAEHMLPHILAHLPSlsdfgskECATKIRKSLGQAFAAEDREFLALA
|.| ..|  |.  || ..|               . ..|| .||| | .|.....|... ..|..| .          ......| .|| | ....|.||
gaasdigrvrkvneDavlv...............glllfavaDGhgghaagevasellvetllellle.......lllldleealrkaflaaneallela

RAGQPQWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEAptvadtesvlpmlvdqdiatLVLTKDHNPVVYEERQRIQKAGGSVtdnRVQGVLGVSRS
.| .. .  |.||.|.|  .. |..|||||  |.|.| ...                    . ||.||.||  .|||||..||| |   || |.| ..|.
laspelagmgtTavvalldggklyvanvGDsrayllrdgkl....................vqltedhspvnelerqriitaggav...rvpgrlaltra

IGDGRYKhlgvssqPFTSKCTLDPNKdlFLVLACDGLWGTLSASDVIQFCMKafgeaeqddqlagqpkLQATHVAARLANHAVEKGASDNVSVLLVRF
.||  .|       | .. ..|.|.   ||.||.||||. || .........                | . ..| ||...|...|  ||..|..||.
lGdlllk.......pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs................ldleeaaerlvelalarggrDNiTvvvvrl
PP2C Protein phosphatase 2C 28-314 3.1e-53 173.9 Pfam-A 7-255 (255) alignment 
Range on Protein: 28-314
Range on HMM: 7-255/255.0
ERRGAREAIEDVCVVQEQLDLQrqacARISSAAYFACFDGHAGRRAADHCAEHMLphilAHLPSLSDFGSKEcatKIRKSLGQAFAA-EDREFLALARAg
| .|||. .|| ..  ..|  .     . || |.|| ||||.||.||. ..||.      .| . ..| . |   | .| | ..|.| .| |.   . . 
elqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehle....eilkeqksflele...kvekalrksfladtdeelksskan.

QPQWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEAPtvadtesvlpmlvdqdiatLVLTKDHNPVVYEERQRIQKAGGSVT-DNRVQGVLGVSRSIG
. ..| |.||.|.|  .. |..|||||..|.|.| ..|                      ||.|| |   .||.||..|||||   .||.|.| |||..|
tepsksGstavvalirgkklyvAnvGDSravLcrkdnak...................keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalG

DGRYKH---LGVSSQPFTSKCTLDPNkDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEqddqlagqpklQATHVAARLANHAVEKGASDNV
| ..|      ||..| ... .|... | ||.||.||||  ||  ...... .   . .           ... .| .|...|...|..||.
dfelkpkeeqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk...........spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 28-314 3.1e-53 173.9 In-house 7-255 (255) alignment 
Range on Protein: 28-314
Range on HMM: 7-255/255.0
ERRGAREAIEDVCVVQEQLDLQrqacARISSAAYFACFDGHAGRRAADHCAEHMLphilAHLPSLSDFGSKEcatKIRKSLGQAFAA-EDREFLALARAg
| .|||. .|| ..  ..|  .     . || |.|| ||||.||.||. ..||.      .| . ..| . |   | .| | ..|.| .| |.   . . 
elqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehle....eilkeqksflele...kvekalrksfladtdeelksskan.

QPQWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEAPtvadtesvlpmlvdqdiatLVLTKDHNPVVYEERQRIQKAGGSVT-DNRVQGVLGVSRSIG
. ..| |.||.|.|  .. |..|||||..|.|.| ..|                      ||.|| |   .||.||..|||||   .||.|.| |||..|
tepsksGstavvalirgkklyvAnvGDSravLcrkdnak...................keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalG

DGRYKH---LGVSSQPFTSKCTLDPNkDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEqddqlagqpklQATHVAARLANHAVEKGASDNV
| ..|      ||..| ... .|... | ||.||.||||  ||  ...... .   . .           ... .| .|...|...|..||.
dfelkpkeeqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkk...........spmeaaeelvdeaiargsedni
PPM_PTC7 28-314 1.1e-50 165.5 In-house 7-259 (259) alignment 
Range on Protein: 28-314
Range on HMM: 7-259/259.0
ERRGAREAIEDVCVVQEQLDLQrqacARISSAAYFACFDGHAGRRAADHCAEHMLphilAHLPSLSDFGSKEcatKIRKSLGQAFAA--EDREFLA-LAR
. .|.|. .||....  .|  .     . .| |.|| ||||.||.||. ..||.      .| . ..| . |   |  | |  .|.|   | |.    |.
afqgfrksmedahialanless....sgkdsvaffavfdghggreaakyarehle....eilkerksfeele...klekalrksflaldtdeelkssean

agQPQWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEAPtvadtesvlpmlvdqdiatLVLTKDHNPVVYEERQRIQKAGGSVT---DNRVQGVLGVS
  .  .. |.||.|.|  .. |..|||||..|.|.| ..|                      ||.||.|.  .||.||..|||||    ..|| ||| ||
..tepstsGstAvvalitgsklyvAnvGDSravLcrsgnav...................kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavs

RSIGDGRYKH-----LGVSSQPFTSKCTLDPNkDLFLVLACDGLWGTLSASDVIQFCMKAFGEAeqddqlagqpklQATHVAARLANHAVEKGASDNV
|..|| ..|        ||. | .|. ..|.. | ||.||.||||  .|  ...... . . .             ... .| .|...|...|..||.
RafGdfelkpketeeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk............dpmeaaeklvdeaiargsedni
subfamily_PPM1D_pd Subfamily PPM1D 29-217 9.2e-24 77.1 In-house 9-177 (309) alignment 
Range on Protein: 29-217
Range on HMM: 9-177/309.0
RRGAREAIEDVCVVQeqldLQRQACARISSAAYFACFDGHAGRRAADHCAEHMLPHILAHlpslSDFGSKEcATKIRKSLGQAFAAEDREFLALAR----
..| |. .|||....    |...  |.  . |..| |||| |. || .  ||..  |  .    ..| |.|   .... . .|| |  ..     .    
dqGgrkymeDvvaiv....leeeesaeelevafvavfDGHGGkeAakfarehlwsvikkq....kkflsse.pedvleAireaflatheamkkkleeWpk

--AGQPQwKDGCTATVCLALNDVLFTANVGDAKAILVRYKEaptvadtesvlpmlVDQDIATLVLTKDHNPVVYEERQRIQKAGGSVTDNrvQGV
   |..    | ||.| .  .. |..|.|||....|   ..               .. . . .||||| |   ||..||...||.|...  .||
tksglls.taGttasvviirreklyvahvGDsaivlgvkep..............kekklrakeltkdHkPespeekerieelGGevaak..sGv
subfamily_PPM1E_pd Subfamily PPM1E 29-165 1.8e-18 59.7 In-house 11-135 (265) alignment 
Range on Protein: 29-165
Range on HMM: 11-135/265.0
RRGAREAIEDVCVVQEQLDLQRQAcARISSAAYFACFDGHAGRRAADHCAEHMLPHILAHLPSLSDFGskecatkirKSLGQAFAAEDREFLalARAGQP
 .. |   || .|. |.|.   .     .  |.|| ||||.|  ||.. |.|.  ..  .    .|           . | .|| . |..||  ..| . 
vknkrrkmEDrhvaledlnelfel.kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.........ealkeafkltDerfl..qkaere

QWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEAP
..| |.|| |.|  .| |. | .||..|.|||  || 
klksGstavvvliekdqlyvaWlGDsqallvrkgeav
subfamily_PPM1G2_pd Subfamily PPM1G2 30-320 4.6e-36 117.2 In-house 27-285 (287) alignment 
Range on Protein: 30-320
Range on HMM: 27-285/287.0
RGAREAIEDVCVVQEQLdLQRQacaRISSAAYFACFDGHAGRRAADHCAEHMLPHILAhlpslsdfgSKEC-ATKIRKSLGQAFAAEDREFLALARAGQp
.| |   ||  .....| |...     .|.|.||.|||| |...| ......   | .          |.    .... | .|| . |.|.|   .  . 
qGyrlnmeDahilenel.leks...ddkslalfavfDGhGGakvakyagkklikkiak.........kksfkegaleqilkdafletDeellkdeklkd.

qWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEAPTVadtesvlpmlvdqdiatlvlTKDHNPVVYEERQRIQKAGGSVTDNRVQGVLGVSRSIGDGR
  . |.||.| |  .. |. ||.||..|.|    .. ..                    . || |   .|..||..||| |  |||.|.| .||..||  
.esaGstavvvlikeeklyvanaGDsravlsskgnvkal....................sfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfe

YKHLG--------VSSQPFTSKCTLDpNKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEQDDQLAGqpKLQATHVAARLANHAVekGaSDNVSVLLVR
.|.          |   |      || ..| ||||||||.|  |. ..|.... . . .  . |...   .|  . .|    | .|  |  ||..|..| 
fkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiie..elldkclapdssntgv..G.cDnmtvvivv
subfamily_PPM1L_pd Subfamily PPM1L 31-322 1.8e-28 92.6 In-house 14-267 (269) alignment 
Range on Protein: 31-322
Range on HMM: 14-267/269.0
GAREAIEDVCVVQEQLDLQrqacariSSAAYFACFDGHAGRRAADHCAEHMLPHILAHLPSLSDFGSKECATKIRKSLGQAFAAEDREFLALARAGQpqW
| |. .||   ..|... .        .  .|| |||| |  ||... . .   |...|  |     ..   .  | | .   . |...|  |.. .   
Grrprmedrfeieediknk.......tgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakrae..d

KDGCTATVCLALNDVLFTANVGDAKAIlvrykeaptvadtesvlpmLVDQDIATLVLTKDHNPVVYEERQRIQKAGGSVTDN---RVQGVLGVSRSIGDG
  |.|| . |  .. |  |||||.. .                   |.|..  .. |. || |   .||.||.|||| .. .   ||.||| .||..|| 
iaGttalialvqesdlivanvGdsrGv...................lydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdy

RYKHLG-VSSQPFTSKCTLDPNKDLFLVLACDGLWGTLSASDVIQFCMKAFGEaeqddqlagqPKLQathvAARLANHAVEKGASDNVSVLLVRFA
  |.   | ..|      ||  |  ||.||.|||| |.|  . ..| .. ..|          |..     |  |. ..  .|. ||..||.|.. 
plkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlke..........pdfG....akslvlesfkrGsvdnitvlvvklk
subfamily_KAPP-like_pd Subfamily KAPP-like 31-319 8.8e-28 90.1 In-house 7-264 (266) alignment 
Range on Protein: 31-319
Range on HMM: 7-264/266.0
GAREAIEDVCVVQEQLdLQRQACARISSAAYFACFDGHAGRRAADhCAEHMLPHILAH-LPS-LSDFGSKEcATKIRKSLGQAFAAEDREFLALAragqp
|.   .||| . .  | |. .  . .|  | || ||||||. ||| .|....|..| . | |   | | ..   . .| | .||   | ..         
gcstemedvslaiypl.lkekklsncsnialfavfdGhaGkGaad.aakklfpkelekllkstkqddGGdn.iydqskllenafkevdaklkdfe.....

qwKDGCTATVCLALNDVlftanvgdakaiLVRYKEAPTVADTESVLPmlvdQDIATLVLTKDHNPVVYEERQRIQKAGGSVTDN--RVQGVLgVSRSIGD
   .|.|||..|  .|               ||  .  | |. . |     .   .| |.|||.    ||.|||.. | ...||  |..|.. |||..||
..yeGatatlalvwsdG............qqrylqvanvGdssafls....rGneslelskdhkakdpeekqrikddGitlsdnqtrinGla.vsralGd

GRYKHL--GVSSQPFTSKCTLDPNKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEQDDQLAGQpKLQaTHVAARLanhavekgASDNVSVLLV
   |.|  |..|.|. |.  |   .| ||..| ||||  .|  | |.     . . . .|..|    |. | . . .        | |||||..|
hfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmass.lle.taiqsik........akdnvsvivv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 31-319 1.7e-27 89.0 In-house 6-274 (276) alignment 
Range on Protein: 31-319
Range on HMM: 6-274/276.0
GAREAIEDVCVVQEQLdLQRQACARISSAAYFACFDGHAGRRAADhCAEHMLPHILAHLPSL-------SDFGSKEcATKIRKSLGQAFAAEDREFlala
|.   .||| . .  | |. .  . .|  | || ||||||. ||| .|....|..| .|           | | ..   . .| | ..|   | ..    
gcstemedvslaiypl.ldekdlsncsnialfavfdGhaGkGaad.aakklfpkelekllksgnysltkqddGGdn.iydqskllldlfkevdakl....

ragQPQWKDGCTATVCLALNDvlftanVGDAKAILVRYKEAPTVADTESVLPmlvdQDIATLVLTKDHNPVVYEERQRIQKAGGSVTDN--RVQGVLgVS
   .    .|.|||..|  .|        . .    || ..  | |. . |     .   .| |.|||.    ||.|||.. | ...||  |..|.. ||
...kdfeyeGatatlalvwsd......GeeqqqqqqrylqvanvGdssafls....rGneslelskdhkatdpeekqrikddGitlsdnqtrinGla.vs

RSIGDGRYKHL--GVSSQPFTSKCTLDPNKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEQDDQLAGQpKLQaTHVAARLanhavekgASDNVSVLLV
|..||   |.|  |..|.|. |.  |   .| ||..| ||||  .|  | |.     . . . .|..|    |. | . . .        | |||||..|
ralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmass.lle.taiqsik........akdnvsvivv
PPM_PTC7_SpoIIE 31-285 1.5e-21 70.3 In-house 10-213 (230) alignment 
Range on Protein: 31-285
Range on HMM: 10-213/230.0
GAREAIEDVCVVQEQLDLQrqacARISSAAYFACFDGHAGRRaaDHCAEHMLphilAHLPSLS----DfgskecatKIRKSLGQAFAA--EDREFLalar
|||. .||....  ..        . ..|.... .||| ||     .....       | .|.    .        |  . |. ...|   | |      
garksmedahispanseks....sggrlalvvgdvdGhGgra..alamgllr....talrelafagle........kpeeilrrlnlalaadlede....

agqpQWKDGCTATVCLALNDV--LFTANVGDAKAILVRYKEAptvadtesvlpmlvdqdiatlvltkdhnpvvyeERQRIqKAGGSVT----DNRVQGVL
     .. |.||.|.|  ..   | .||.||  ..||| ..                                  || || .||| .     ..|| |||
....psssgaTavvalidpstgklyvanaGdsppllvrddgg.................................ereri.vagglpslGilpgrvfgvl

GVSRSIGDGRYKH--LGVSSQPFtSKCTLDPNKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAeqddQ
 ||...||  ...    |.. |  .. .....|| ||.||.||||  ||. ........ ...      
avslapGdllllytDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp....a
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 57-217 1.2e-12 41.0 In-house 17-156 (292) alignment 
Range on Protein: 57-217
Range on HMM: 17-156/292.0
SSAAYF--ACFDGHA--GRRAADHCAEHMLPHILAHLPSLSDFgSKecaTKIRKSLgqAFAAEDREFLALARagqpqwKDGCTATVCLALNDV--LFTAN
|.|  |  | .|||   |.. |.  ....  ..|   . | .  |.   . . . |    ||. ..  . ||      . . ||.||   .|   |. ||
sealtflaavldGhGvnGdkvaqlaedtlevelleltrqlqel.se...alllril..diaakldkltidar......esattavvcarvrddralilan

VGDAKAILVRykeaptvadtesvlpMLVDQDIATLVLTKDHNPVVYEERQRIQKAGGSVTDNRVQGV
|||..|.| |                |   |     |..|| |   .||.||..||| |.  ||.| 
vGdsrallgr...............clggsdyeliPlsrdhkPedPderarilraGGrveptrvrgw
subfamily_PPM1K_pd Subfamily PPM1K 60-321 3.6e-28 91.4 In-house 32-258 (263) alignment 
Range on Protein: 60-321
Range on HMM: 32-258/263.0
AYFACFDGHAGRRAADHCAEHMLPHILAHLPslsdfgsKEcaTKIRKSLGQAFAAEDREF---LALARAGQPQWKDGCTATVCLALNDV-LFTANVGDAK
 |.| ||||||  |||.. ...  ..   |.       ||   .... | .||   |...   | .  | . . . | ||||.|  . . |  |..||..
lyvavfdGhaGsaaadfvhdklekilkrlle.......ke..kdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsr

AILVRYKEAptvadtesvlpMlvdqdiatlVLTKDHNPVVYEERQRIQKAGGSVTDN-----RVQGVLGVSRSIGDGRYKHLGVSSQPFTSKCTLDPNKD
||| |  .|           .          ||.||.|   ||..||..|||||. |     .| |.| ..||.||   |. || ..| | .  .| ..|
ailcrnGka...........k.........kltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaad

LFLVLACDGLWGTLSASDVIQFCmkafgeaeqddQLAGQPKlQAthvAARLANHAVEKGASDNVSVLLVRF
 ||||  ||.   ..  .. ..            .|  .|. .|   |  |.. |.. |. ||.....| .
sflvlitdgisfvvnsqelcdlv...........rlchdpe.ea...ahalteqalqygsednatavvvpl
Subfamily Dicty-PPM1L-like 60-321 1.7e-15 49.6 In-house 38-303 (305) alignment 
Range on Protein: 60-321
Range on HMM: 38-303/305.0
AYFACFDGHAGRRAADHCAEHMlPHILAHLPSLSDFGS--K--ECATKIRKSLGQAFAAEDREFLALARAGQPQW---KDGCTATVCLALNDVlFTANVG
 .|  |||| | .||..   ..  .|. .       |   |         ... .|. . |. .|. | ... .     .| .|.| |  . .  ... .
slfGvfdGhnGdiaaeyvkkkl.veivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGttlngssasvilerert.ivstas

DAKAILVRYKEAPTVADTESVLPMLVDQD-IATLVLTKDHNPVVYEERQRIQKAGGSVTDN---RVQGVLGVSRSIGDGRYKHLGVsSQPFTSKCTLDPN
|... |     |  ..  .|   . .|      .    ..| .  |.| ||. ..... .    .| ..| .|||.||.  | | .  ..      .   
dtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGdknlkelvi.Pnndspllvvaka

KDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEQDDQLagqpKLQATHVAARLANHAVEKGASDNVSVLLVRF
 | ||||| ||||  ||  ||...  .   .  .. ..    .     .  . .. ||..|  ||. .... .
nDqflvlatdGlwevlsyqdvveevkellrdkssqkki....ewdfneisrviveeavkrgsgDnitlviikl
PP2C_SIG_SM00331 62-321 1.3e-09 30.9 In-house 33-217 (217) alignment 
Range on Protein: 62-321
Range on HMM: 33-217/217.0
FACFDGHAGRRAADHCAEHMLPHILAHLPSLsdfgskecatkirKSLGQAFAAEDREFLALaragqPQWK-DGCTATVCLA--LNDVLFTANVGDAKAIL
.. .||. .  ||  ... ... .  .| .              ..| ||. . .| . ..      . |  ..|....|    .. |  ||.||   .|
lvvaDgmGkGlaAaaassqlrtalrellseg.............eelsqalkrlnraiyee.....keekgmfaTlllalydfssgklsyanaGdsrpyl

VRykEAPTVADTESvlpmlvdqdiatlvltkdhnpvvyeerqriqkaggsvtdnrvqgvlgvsrsigdGRYKHLGVSSQPF--TSKCTLDPnkDLFLVLA
.|  .. .| ....                                                       . . ||. ...   ... .|..  . .|.|.
lr..dgklveilkd......................................................vegaplGlepevsvdirelelek..gdlllly

CDGLWGTLSASDVIQFCMKAFGEAEQddqlaGQPKLQATH-VAARLANHAVEKGASDNVSVLLVRF
 |||.   |. .. .. .. . |. .     .... . ..   ..| ..| ... .|...|..|..
tDGltearsekgfaeerleeiledlv.....dseaqelaqkiveellelakgsngeDdiTvvvvkv
subfamily_PPM1G_pd Subfamily PPM1G 127-321 1.1e-29 96.8 In-house 291-470 (473) alignment 
Range on Protein: 127-321
Range on HMM: 291-470/473.0
QPQWKDGCTATVCLALNDVLFTANVGDAKAILVRYkeaptvadtesvlpmlvdqdIATLVLTKDHNPVVYEERQRIQKAGGSVT-DNRVQGVLGVSRSIG
.|  . |.||.|.|  .. |. ||.||....| |                        | |  || |   .|..||.|||| |. | ||.| | .|| .|
epGedsGttAvvaLlkekklivAnaGDsRcvlsrn....................GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlG

DGRYKH---LGVSSQ-----PFTSKCTLDPnKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEQDdqlaGQPKLQATHVAARLANHAVEKGA-SDNVSV
|  ||.   |.   |     |   . || . .| ||||||||.| .... .|..|  . . . |..       ..  . . | ||.     |.  || .|
DhaYkkneeLplkeqmisAlPDikvltlte.edeFlvlAcDGiWnvmesqevvdfvraklkkgees....vlseiveeLlDaclapdtsgDGtGCDnmtv

LLVRF
..| .
iivll
subfamily_PPM1H_pd Subfamily PPM1H 127-204 1.5e-09 30.1 In-house 157-212 (404) alignment 
Range on Protein: 127-204
Range on HMM: 157-212/404.0
QPQWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEAptvadtesvlpmlvdqdiatLVLTKDHNPVvyEERQRIQK
. . | |||| | | |.. |. || ||..||||| .|                       | .|. |    ||||.|.
ayrikGGCtalvalvllgklYvanaGDsRailvrkdei....................iplsadftPe..teRqRlqe
subfamily_TAB1_pd Subfamily TAB1 129-227 5.8e-07 21.6 In-house 126-210 (333) alignment 
Range on Protein: 129-227
Range on HMM: 126-210/333.0
QWKDGCTATVCLALNDVLFTANVGDAKAILVRYKEaptvadTESvlpmlVDQdiatlvLTKDHNPVVYEERQRIQKAG---GSVTDNRVQGVLGVSRSIG
. ..| || | | .|. |. |||||..|.||. ||      .|      | |      | .||.    .| .|... |     .  |.. |     ||||
eisgGttAvvalifnnkLyVaNvGdsrAllvkrke......sek.....vkq......LsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiG

DG
| 
dy
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 133-287 1.8e-07 22.7 In-house 135-292 (317) alignment 
Range on Protein: 133-287
Range on HMM: 135-292/317.0
GCTATVCLALNDVLF-TANVGDAK-AILVRYKEAPTVADTESVLPMlVDQDIATLVLTKDHNPVVYEERQRIQKAGGSV-TDNR-VQGVLGVSRSIGDGR
|.||.| . .... . .|| |||   .|.| .. .  .|  ||  .   .  .     ..    |. ..  . . |     |.   .  | ...|.|  .
GttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsveal.svrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhkl

YKHLGVSSQPFTSKCTLDPNKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEQDDQLA
 |  ||. .|     .|| ..   .|   ||.   |.  ||.   ..|    |  ..| 
lkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlc
subfamily_PP2D1_pd Subfamily PP2D1 139-281 9.9e-17 53.8 In-house 183-310 (492) alignment 
Range on Protein: 139-281
Range on HMM: 183-310/492.0
CLALNDVLFTANVGDAKAILVRykeaptvadtesvlpmlvdQdIATLVLTKDHNPVVYEERQRIQKAGGSVTDN----RVQGVLGVSRSIGDGRYKHL--
 |    ||. ||.|. .|.|.|                   .   . .||..|.|   .||.|..|||..|. .    .|.|.|.. | .|     .|  
hleelgvlyianaGnvqAvLcr...................e.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkk

GVSSQPFTSKCTLDpNKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAE
 |  .| |   .|| ... |||||  |||  ||. .|..  .. .   .
svipePkttsvkld.eaaqflvlAsnGlWevlseeevlsLvkqtlaiyk
subfamily_PPM1E_pd Subfamily PPM1E 179-321 5.1e-25 81.1 In-house 129-262 (265) alignment 
Range on Protein: 179-321
Range on HMM: 129-262/265.0
DQDIATLVLTKDHNPVVYEERQRIQKAGGSVT---DNRVQGVLGVSRSIGDGRYKHLgVSSQPFTSKCTLDPNKDlFLVLACDGLWGTLSASDVIQFCMK
 ... .. |.| |.|   .|..||..||| |      || ||| |||.||| ..|.  ||... .....|| ... .|.||||||| ..  ..|..   .
vrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpy.vsgeadvaeveldgsee.ylilacDGlwDvvneeevvklvee

AFGEaEQDDqlagqpklqATHVAARLANHAVEKGASDNVSVLLVRF
 . . ...|          ..||  | ..| |.|.|||..|..| .
flad.gaed.........lsevakllveaakeagssDnitvvvvfl
subfamily_PPM1A_pd Subfamily PPM1A 183-322 5.9e-35 114.0 In-house 146-281 (282) alignment 
Range on Protein: 183-322
Range on HMM: 146-281/282.0
ATLVLTKDHNPVVYEERQRIQKAGGSVTDNRVQGVLGVSRSIGDGRYKH--------LGVSSQPFTSKCTLDPNKDlFLVLACDGLWGTLSASDVIQFCM
..  ||.|| |   .|..||..|||||. .||.| | |||..||  ||.        . ||..| .  .  . ..| ||||||||.| .|| ..|...  
kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvr

KAFGEAEQDDQLagqpklqathvAARLANHAVEKGASDNVSVLLVRFA
| .. |..  ..           |..| ..| |||. ||.|||.| ||
krlevadeleev...........akalvdkalekgsrDNlsvlvvlfa
subfamily_PHLPP_pd Subfamily PHLPP 184-273 4.5e-08 25.3 In-house 125-212 (246) alignment 
Range on Protein: 184-273
Range on HMM: 125-212/246.0
TLVLTKDHNpVVYEERQRIQKAGGSVT-DNRVQGVLGVSRSIGDgRYKHLGVSSQPFTSKCTLDPNkDLFLVLACDGLWGTLSASDVIQFC
 | |.| .  .  .| .||..| . .| ||...||.. .| .|   . .  |  .|  .. .| .. | .|..  . || .||  .. .  
klrlsksyv.iekdelkrikeakaiitednkingviestrllGy.tflfPvvlPkphvrevlLteq.dellivGnkalWevlsideaveav
subfamily_PPM1D_pd Subfamily PPM1D 218-321 1.5e-12 40.3 In-house 201-307 (309) alignment 
Range on Protein: 218-321
Range on HMM: 201-307/309.0
LGVSRSIGD-----GRYKHLGVSSQPFTSKCTLDPNKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEQDDQLAgqPKLQATHVAARLANHAVEKGASD
| |.||.||      . ..  || .| ... |||||.. |..|| ||||  |...|......|     |  ..     .   . |   | . . .|  .|
LavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs..rsvakalvkealqrwrskklraD

NVSVLLVRF
||||..| .
nvsvivvil
subfamily_PDP_pd Subfamily PDP 243-322 1.6e-08 27.1 In-house 279-359 (398) alignment 
Range on Protein: 243-322
Range on HMM: 279-359/398.0
CTLDPnKDLFLVLACDGLWGTLSASDVIQFCMKAFGEAEQDDQLAGQP-KLQATHVAARLANHAVEK-GASDNVSVLLVRFA
  | . .| ||||| |||| .|| ..|..  .. . ......... .. ||. ..|  .|.... ..  .. |.   |.| |
hklre.ndkFLvlatDGLwdllsneevvslVgehlakkkekepvkveeakltlkqvveelkerkrklkredknaAthLirha
PPM_PTC7_SpoIIE_motif 252-321 6.2e-06 19.8 In-house 14-80 (81) alignment 
Range on Protein: 252-321
Range on HMM: 14-80/81.0
FLVLACDGLWGTLsASDVIQFCMKAFGEAEQDDqlAGQPklqATHVAARLANHAVEKG---ASDNVSVLLVRF
 |.|..|||. .   ||   |  ... .. ..    |..   . ..| .| ....| |    .|....|..|.
vllLyTDGltEar.dsdgelfgkeellrladra..egks...lqeladklvdevlengsgereDDitllvlrv
PPM_PTC7_motif 254-314 3e-06 20.6 In-house 1-51 (51) alignment 
Range on Protein: 254-314
Range on HMM: 1-51/51.0
VLACDGLWGTLSASDVIQFCMKAFGEAEQddqlagqpklQATHVAARLANHAVEKGASDNV
.||.||||  ||  ...... .   .  .          . . .| .|...|...| .||.
iLAsDGLWDvlsdqeavdlvrdqlskkgl..........spqeaAeklvdealargseDni