Gene PPM1A-1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP128_AA protein Get Run
MbreP128_AA_19-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 20-302 4.2e-77 251.7 In-house 3-291 (295) alignment
Range on Protein: 20-302
Range on HMM: 3-291/295.0
FLPSPKTDITSMDQRTADQKFGLAYMQGWRAHMEDAHITQPELPG-LPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYELLP----VKDSLHAISDAMHR
.|. |.......       ..| | .||.| ..|||... ..|.  |...... | ||| | ..|..  ..|.  .| .|        .||. | .|...
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrk

AFLRHDRALFADNKV--RLDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAISRAFGDFDYK
|||. |..|.. .    .|..|| |.. .|. ...... |.|||| .|.|.|.| . |.||||  . || ||..|||.|..||| |.||..||.||||.|
aflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlk

RNPQLGALEQKVVADPDVTLVERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRrSPDNPKAVCQALLKRCLELGSRDNMSACLVVFN
....| .||. |.| |||| .|..||.||||||..||..||.|| .....|.. |. . .........|....|. |||||.....| .|
lllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.kgldleeaaeeLvdlAlargsrDNiTvvvvrln

subfamily_PPM1G_pd Subfamily PPM1G 21-128 2.3e-19 62.8 In-house 2-104 (473) alignment
Range on Protein: 21-128
Range on HMM: 2-104/473.0
LPSPKTDITSMDQRTADQKFGLAYMQGWRAHMEDAHITQPELPGlpGWSFYSVIDGHAGAEVAHYSEDHLLaSVLYELLPVKDSlhAISDAMHRAFLRHD
|  ||.. .| |. . . ..| . |||||. .|||| . ..|     .|...| ||| |.|||.|  ..|.  .| .    |.    .. |.. |||  |
lskpkvekesedesneelsygasamqGwrvsqEDahncitdlde..dtslfavyDGHGGkevakyvakklp.dllkaqkgykeg..dvekaleeaflalD

RALFADNK
. | |.. 
eklkaees

subfamily_PPM1A_pd Subfamily PPM1A 30-302 2.8e-104 341.4 In-house 4-281 (282) alignment
Range on Protein: 30-302
Range on HMM: 4-281/282.0
SMDQRTADQKFGLAYMQGWRAHMEDAHITQPELPGLPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYE-----LLPVKDSLHAISDAMHRAFLRHD---R
........ ..|...|||||..|||||... .|..|..|||..|.|||||.|||.|...|||...| |         ... .....|....||..|   |
ksqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeair

ALFADNKVRlDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAISRAFGDFDYKRNPQLGALE
.|..|.| . |.|| |...||||..|.|..||||||..|||.|| ||.|.||||. |.|..||..|||.|...||.| ||.|||.||..||......| |
elstdlkta.dksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaee

QKVVADPDVTLVERDLEHDdFLLLCCDGIFDVMSNATAIKFVATKLRRSpDNPKAVCQALLKRCLELGSRDNMSACLVVFN
|.|.|.|.|| .||. |.| ||.|.||||.||.|.......|...|... |....|..||....|| |||||.|...|.|.
qlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrleva.deleevakalvdkalekgsrDNlsvlvvlfa

subfamily_PPM1G2_pd Subfamily PPM1G2 32-302 6e-73 238.3 In-house 13-287 (287) alignment
Range on Protein: 32-302
Range on HMM: 13-287/287.0
DQRTADQKFGLAYMQGWRAHMEDAHITQPELPG---LPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYellpvKDSLH--AISDAMHRAFLRHDRALFAD
  . |  |.| . |||.| .||||||...||      .  ....| ||| ||.||.|.  .|   . .     |.|..  |.. ... |||. |. |  |
scanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.....kksfkegaleqilkdafletDeellkd

NKVRLDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAISRAFGDFDYKRNPQLGALEQKVVA
.|.. ...| |...||.. .. .  | ||||..|.  |..   ..||||   .|..|| .|||||  .|| | ||.|||.||| .|.| .... || | |
eklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivta

DPDVTLVERDlEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSpDNPKAVCQALLKRCLELGSR------DNMSACLVVFN
 |||.. ..| |.|.||.| ||||.||..|.. ...| ..|..   ....... ||..||   |.      |||....||..
vPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsg.akldeiieelldkclapdssntgvGcDnmtvvivvll

PP2Cc_SM00332 38-299 3.9e-70 229.4 In-house 10-274 (274) alignment
Range on Protein: 38-299
Range on HMM: 10-274/274.0
QKFGLAYMQGWRAHMEDAHITQPELPGLPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYELLPVKDS-LHAISDAMHRAFLRHDRALFADNKVRLD---N
  .|.. |||||  |||||.....|    .|.|..| |||.|.||| .  ..|   .  ||  .||   ... .|...|||. | .. ..... ..   .
lsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelenal

SGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAISRAFGDFDYKRNPqlGALEQKVVADPDVTLV
|| |....|..  . .. |.||||  |||.||    ..||||  ..|| ||..|||.|..|||.||||.||||||...|.|   .  |. ..|.|||. |
sGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitaepdvkvv

ERdLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRR-SPDNPKAVCQALLKRCLEL-GSRDNMSACLV
.   ..|.||.|..||..||.|| .....|  .|.. .  .|..... | . ...  ||.||.....|
tl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

0049733 PP2C-like 39-302 4.5e-56 182.7 In-house 4-234 (235) alignment
Range on Protein: 39-302
Range on HMM: 4-234/235.0
KFGLAYMQGW-RAHMEDAHITqpelpglpGWSFYSVIDGHAGAEVAHYSEDHLLASVLYELLPvkDSLHAISDAMHRAFLRHDRALFADNKVR--LDNSG
..| | ..|. | ..|||..         |.... | ||| |......  ..|.  .| .||.   .|. . .|...|||. ..||.. .. .  |. .|
svgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle..lllldleealrkaflaaneallelalaspelagmg

GTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVingRVDGGLAISRAFGDFDYKrnpqlgaleqkvvadpdVTLVER
 |.. .|. . .....|.|||| .|.|.||| . |.||.|  ..|| ||..|||.|   || |.||..||.||...|                 . ... 
tTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.................pdvtvl

DLEHDDFLLLCCDGIFDVMSNATAIKFVATklrrspDNPKAVCQALLKRCLELGSRDNMSACLVVFN
.||..|||||..||..||.|. ........      .........|....|. |.|||... .| ..
elepgdflllasDGlwdvlsdeeivdllrs......ldleeaaerlvelalarggrDNiTvvvvrld

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 39-301 5.6e-42 136.8 In-house 7-253 (255) alignment
Range on Protein: 39-301
Range on HMM: 7-253/255.0
KFGLAYMQGWRAHMEDAHITQPELPGLPGWSFYSVIDGHAGAEVAHYSEDHLlASVLYELLPVKDSlhAISDAMHRAFLRHDRALfadnKVRLDNSGGTC
| | . | | |. |||  .   .  . ..  .|.. |||.| . |... ..|   .| ||| ....  .  .....|.   .  .    . |    | | 
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseel.ykilaelldlnna..nPvkslkkaykeistqi....serpkfiGtta

TSVLVSPTHYIFVNLGDSRSLLC-RGGKLAFQTRDHKPILPQERTRIRNAGGFVING----RVDGGLAISRAFGDFdYkrnpqlgaLEQKVVADPDVTLV
.|||.   ...  |.|||| .|| . |     . ||||  ..|. ||...||.|...    ||.| ||.|||.||  .        ||  ||.|||..  
asvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.f........lePfvvpdPdlsqs

ERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKlrrspDNPKAVCQALLKRCLELGSRDNMSACLVVF
 .  ..| ||.| ||||.|..|.  |.. ||.       .|.  .. |     . || ||.| ... .
leiskkdkflilacdGiwdlisdeeaveivagi.....sdpekaaeklrdlayssGstdnisvivikl

PPM_PTC7 40-294 4.7e-63 206.0 In-house 3-259 (259) alignment
Range on Protein: 40-294
Range on HMM: 3-259/259.0
FGLAYMQGWRAHMEDAHITQPELP---GLPGWSFYSVIDGHAGAEVAHYSEDHLLasVLYELLPVKDSLHAISDAMHRAFLR--HDRALFA--DNKvRLD
.|   .||.| .||||||  . |    |   ..|..| |||.| |.|.| . ||     ... . ...|   ..|.  .||.   |  |    .|.   .
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehle..eilkerksfeeleklekalrksflaldtdeelksseant.eps

NSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLA-FQTRDHKPILPQERTRIRNAGGFVI---NGRVDGGLAISRAFGDFDYKRNPQlgaLEQKVVADP
.|| |....|..... .. |.|||| .|||.|. . . |.|||| ...|| ||..|||.|.   |||| | || |||||||..|...     ||.|.|.|
tsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaeP

DVTLVERDLEhDDFLLLCCDGIFDVMSNATAIKFVATKLRRSpdNPKAVCQALLKRCLELGSRDNM
|.. ...| | |.||.|..||..||.|. .|. .| . |      |  ....|.. ... ||.||.
disstkidee.defliLasdGlwdvvsdqeavdlvrselskk..dpmeaaeklvdeaiargsedni

subfamily_PPM1K_pd Subfamily PPM1K 40-302 1e-36 119.4 In-house 6-259 (263) alignment
Range on Protein: 40-302
Range on HMM: 6-259/263.0
FGLAYMQGWRAHMEDAhITQPELPglPGWSFYSVIDGHAGAEVAHYSEDHLlASVLYELLPVKDSLHAIS----DAMHRAFLRHDRALFADNkvRLDNSG
 | . ..| ||  ||  |.  ||   |   ...| |||||.  |..  |.|   .| .||.  . |. .     . ..... |. . ..|..   | .||
vGkdsliGkraenedr.iklkeld..pellyvavfdGhaGsaaadfvhdkl.ekilkrllekekdleivlknafeeldkklkrylefsvaea..ellssG

GTCTSVLV-SPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVIN-----GRVDGGLAISRAFGDFDYKRNpqlGaleqkVVADPD
 | | .|.   |. .  .|||||..||| ||    ||||.| | .|. ||..|||.|        .|.| ||..|..||.| ||    |     |.|.|.
ttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkry...G.....viatPe

VTLVERDLEHDDFLLLCCDGIFDVMSNATAIKFVatklrRSPDNPKAVCQALLKRCLELGSRDNMSACLVVFN
  ... | ..| ||.|. ||| .|...    ..|     |   .|.   .|| .  |. || || .| .| ..
tkslkvdhaadsflvlitdgisfvvnsqelcdlv.....rlchdpeeaahalteqalqygsednatavvvplg

PPM_PTC7_SpoIIE 40-293 9e-32 103.7 In-house 3-229 (230) alignment
Range on Protein: 40-293
Range on HMM: 3-229/230.0
FGLAYMQGWRAHMEDAHITQPEL---PGLPGWSFYSVIDGHAGAEvaHYSEDHLL---ASVLYELLP-VKDSLHAISDAMHRAFLRHdralfadnkvrLD
.|   .||.| .||||||  . .   .|   . .. . ||| | .  ..   .|    ..  .. |. ... |... .|.....               .
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrelafaglekpeeilrrlnlalaadlede...........ps

NSGGTCTSVLVSPTH--YIFVNLGDSRSLLCRG-GKlafqtrdhkpilpqERTRIrNAGGFV-I---NGRVDGGLAISRAFGDFDYKRnpqlgaLEQKVV
.|| |.. .|. |..    ..|.|||. ||.|. |.              ||.||  |||.. .   .||| | ||.|.|.||. ..        .. | 
ssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvve

ADPDvTLVERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSpdnpkaVCQALLKRCLELGSRDN
| || |  ... ..|.|| |..||..||.|.. .. .|   | .       ....||. .. |.. ..
aepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp......aaeglleDDitllvvrv

PP2C Protein phosphatase 2C 41-294 1.3e-64 211.2 Pfam-A 4-255 (255) alignment
Range on Protein: 41-294
Range on HMM: 4-255/255.0
GLAYMQGWRAHMEDAHITQPEL---PGLPGWSFYSVIDGHAGAEVAHYSEDHLLasVLYELLPVKDSLHAISDAMHRAFLR-HDRALFADNKV-RLDNSG
|   .||.| .||||||  ..|    |   ..|. | |||.| |.|.| . ||    .... . ...|   ..|. ..||.  |  |  ...    ..||
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle..eilkeqksflelekvekalrksfladtdeelksskantepsksG

GTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLA-FQTRDHKPILPQERTRIRNAGGFVI-NGRVDGGLAISRAFGDFDYKRNPqlgalEQKVVADPDVTLV
 |....|..... .. |.|||| .|||... . . |.||||  ..|| ||..|||.|. |||| | || |||.|||..|...     || |.|.|||| |
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsv

ERDLEhDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPdNPKAVCQALLKRCLELGSRDNM
... | |.||.|..||..||.|. .|. .|  .|     .|. ....|.. ... ||.||.
kltee.defliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 41-294 1.3e-64 211.2 In-house 4-255 (255) alignment
Range on Protein: 41-294
Range on HMM: 4-255/255.0
GLAYMQGWRAHMEDAHITQPEL---PGLPGWSFYSVIDGHAGAEVAHYSEDHLLasVLYELLPVKDSLHAISDAMHRAFLR-HDRALFADNKV-RLDNSG
|   .||.| .||||||  ..|    |   ..|. | |||.| |.|.| . ||    .... . ...|   ..|. ..||.  |  |  ...    ..||
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle..eilkeqksflelekvekalrksfladtdeelksskantepsksG

GTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLA-FQTRDHKPILPQERTRIRNAGGFVI-NGRVDGGLAISRAFGDFDYKRNPqlgalEQKVVADPDVTLV
 |....|..... .. |.|||| .|||... . . |.||||  ..|| ||..|||.|. |||| | || |||.|||..|...     || |.|.|||| |
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvtsv

ERDLEhDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPdNPKAVCQALLKRCLELGSRDNM
... | |.||.|..||..||.|. .|. .|  .|     .|. ....|.. ... ||.||.
kltee.defliLasdGlwdvlsdqeavdlvrselskkk.spmeaaeelvdeaiargsedni

subfamily_PPM1E_pd Subfamily PPM1E 42-302 1.6e-43 141.8 In-house 8-263 (265) alignment
Range on Protein: 42-302
Range on HMM: 8-263/265.0
LAYMQGWRAHMEDAHITQPELPGLPG------WSFYSVIDGHAGAEVAHYSEDHLLASVLYELLPVKDSLhaisDAMHRAFLRHDRALFADNKVRLDNSG
.| ... | .||| |.. ..|  | .       .|..| |||.| | |.|.  ||   .  .    .|..    .|...|| . |... .  .    .||
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa....ealkeafkltDerflqkaereklksG

GTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVIN---GRVDGGLAISRAFGDFDYKrnpqlgaleQKVVADPDVTL
 |  .||..  .     ||||..||.| |.    .. |||  ..|. || .|||.|..    ||.| |..||| || ..|         . |....||. 
stavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsgeadvae

VERDlEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPDNPKAVCQALLKRCLELGSRDNMSACLVVFN
|| | .....|.| |||..||. . ...| |   |... .. . | . |..   | ||.||... .|...
veld.gseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfld

subfamily_ILKAP_pd Subfamily ILKAP 43-270 1.7e-34 112.3 In-house 10-246 (293) alignment
Range on Protein: 43-270
Range on HMM: 10-246/293.0
AYMQGWRAHMEDAHITQPELP--------GLPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYElLPVKDSLH---AISDAMHRAFLRHDRALFAD--NKV
|  .| |..|.|||. . .|          .   |.|.| |||||   .... ..|  ..| . || .|       |  ..  .| . |. ...   .. 
aerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek.lpksdvsakekeikkclvdsfkktdeefLklaskak

RLDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLA------FQTRDHKPILPQERTRIRNAGGFVINGRVDGGLAISRAFGDFDYKRnpqLGaleqk
     | | |.|||        |||||...|.|  . .        |.||.|.  .|| ||. |||.| .||| | | .||. ||  .||   ||     
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkr...lG.....

VVADPDVTLVERDLEhDDFLLLCCDGIFDVMSNATAIKFVATKLRRS
|.. |||. .| .   | |..|.|||...|.|.  ..||.   |   
vistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvlede

subfamily_PPM1L_pd Subfamily PPM1L 44-303 5e-39 127.2 In-house 11-268 (269) alignment
Range on Protein: 44-303
Range on HMM: 11-268/269.0
YMQGWRAHMEDAHITQPELPGLPGWSFYSVIDGHAGAEVAHYSEDHLLASVLYELLPV---KDSLH--AISDAMHRAFLRHDRALFADNKVRLDNSGGTC
 ..| | .|||  . . ..    | ||..| ||| |   |....| |  ... .|. .   |.     . |  .    |  |. |    |.  | .| |.
svlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraediaGtta

TSVLVSPTHYIFVNLGDSRSLLCRG-GKLAFQTRDHKPILPQERTRIRNAGGFV-ING--RVDGGLAISRAFGDFDYKRNpqlgaleQKVVADPDVTLVE
   ||. .. |  |.|||| .|.   ||    . ||||  ..|| ||..||||. ..|  || | ||.|||.||.  | .       . |.||||.   .
lialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk.......nlviadpdiltfd

RDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLrrspDNPKAVCQALLKRCLELGSRDNMSACLVVFNK
 |  . .||.| .||..| .||  |..|.  .|    ..|.   ..|  ..   || ||..  .|....
lddhkpeflilasdGlwdtfsneeavrfikerl....kepdfGakslvlesfkrGsvdnitvlvvklkn

subfamily_PPM1D_pd Subfamily PPM1D 45-193 2.8e-18 59.1 In-house 9-173 (309) alignment
Range on Protein: 45-193
Range on HMM: 9-173/309.0
MQGWRAHMEDAHITQ--PELPGL-PGWSFYSVIDGHAGAEVAHYSEDHLLASVLYELLPVKDSLHAISDAMHRAFLRHDRAL------FADNKVRLD-NS
 || | .|||    .  .|  ..  ...| .|.||| | | |..  .||.  .  .   . .. ... .|...|||   .|.      .. .|  |   .
dqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllsta

GGTCTSVLVSPTHYIFVNLGDSRSLLCRGGK------LAFQTRDHKPILPQERTRIRNAGGFVIN
| |.. |..  ..    . |||. .|    .          |.||||  |.|..||...|| | .
GttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa

subfamily_KAPP-like_pd Subfamily KAPP-like 68-298 4.1e-18 58.4 In-house 34-263 (266) alignment
Range on Protein: 68-298
Range on HMM: 34-263/266.0
WSFYSVIDGHAGAEVAHySEDHLLASVLYELLPVKDSLHAISDAMHRAFLRHDRALFADNKV-RLDNSGGTCTSVLVSP---THYIF-VNLGDSRSLLCR
 ....|.|||||  .|  . ..|.  .| .||   .  .   .  ..  | ..     |.|.   .  | | | .||      .|.   |.||| ..|.|
ialfavfdGhaGkGaad.aakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssaflsr

GGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVD-GGLAISRAFGDFDYKRnPQLGALEQKVVADPdVTLVerdlEHDDFLLLCCDGIFDVMSNATAIK
| .  . . |||   |.|. ||.. |  . ...    |||.|||.||   |.  ..|   .  |... ..|      .|.||..  ||..||.|   ||.
GneslelskdhkakdpeekqrikddGitlsdnqtrinGlavsralGdhfike.lniGlisepyvsnr.illt....pfdkflivasdGlwdvisGkdaie

FVATKLRRSpDNPKAVCQALLKRCLE-LGSRDNMSACL
 | .   .  .  . ....||.  ..   ..||.|  .
kvkslydqq.atedkmasslletaiqsikakdnvsviv

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 70-211 1.6e-16 53.7 In-house 22-185 (292) alignment
Range on Protein: 70-211
Range on HMM: 22-185/292.0
F-YSVIDGHA--GAEVAHYSEDHLLAsvlyELLPVKDSLHAISDAMHRAFLrHDRALFADNKVRLDNSGGTCTSVLVSPTH--YIFVNLGDSRSLLCR--
|  .|.|||   | .|| ..||.|      ||| .   | ..|.|.    |    | . .  .   .|..|..   . .     |  |.||||.|| |  
flaavldGhGvnGdkvaqlaedtlev....elleltrqlqelsealllril.diaakldkltidaresattavvcarvrddralilanvGdsrallgrcl

GG---KLAFQTRDHKPILPQERTRIRNAGGFVI-----------NGRV------DGGLAISRAFGDFDY
||   .|   .|||||  |.|| ||..|||.|              ||      .|.||.||| |||  
ggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhl

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 70-298 7.8e-16 50.7 In-house 35-273 (276) alignment
Range on Protein: 70-298
Range on HMM: 35-273/276.0
FYSVIDGHAGAEVAHySEDHLLASVLYELLPV-KDSLHAISDAMHRAFLR----HDRALFADNKVR-LDNSGGTCTSVLVSPTH---------YIF-VNL
...|.|||||  .|  . ..|.  .|  ||   . ||    |  .  . .     |     |.|..  .  | | | .||             |.   |.
lfavfdGhaGkGaad.aakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqrylqvanv

GDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVINGRVD-GGLAISRAFGDFDYKRnPQLGALEQKVVADPdVTLVerdlEHDDFLLLCCDGIFD
||| ..|.|| .  . . |||   |.|. ||.. |  . ...    |||.|||.||   |.  ..|   .  |... ..|      .|.||..  ||..|
GdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinGlavsralGdhfike.lniGlisepyvsnr.illt....pfdkflivasdGlwd

VMSNATAIKFVATKLRRSpDNPKAVCQALLKRCLE-LGSRDNMSACL
|.|   ||. | .   .  .  . ....||.  ..   ..||.|  .
visGkdaiekvkslydqq.atedkmasslletaiqsikakdnvsviv

PP2C_SIG_SM00331 89-298 3.3e-12 39.4 In-house 54-214 (217) alignment
Range on Protein: 89-298
Range on HMM: 54-214/217.0
HLLASVLYELLPVKDSLHAISDAMHRAflrhdralfadnkVRLDNSGGTCTSVLV--SPTHYIFVNLGDSRSLLCRGGKLAFQTRDhkpilpqertrirn
..|   | |   ... |... .|...                 .... |..  |.  |  .  ..|.|||| .| | ||| ... |              
talrellsegeelsqalkrlnraiyee.............keekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd..............

aggfvingrvdgglaisrafgdfdyKRNPQLGALEQKVvadpdVTLVERDLEHDDFLLLCCDGIFDVMSNAT-AIKFVATKLRRSP----DNPKA-VCQA
                         .. ..||  ..       |.  |..|| .|.|||. ||.....| .. | . . . |. .     .  ..   . 
.........................vegaplGlepevs.....vdirelelekgdllllytDGltearsekgfaeerleeiledlvdseaqelaqkivee

LLKRCLELGSRDNMSACL
|| .  . . .|...  .
llelakgsngeDdiTvvv

subfamily_PPM1H_pd Subfamily PPM1H 109-186 8.1e-06 17.8 In-house 137-212 (404) alignment
Range on Protein: 109-186
Range on HMM: 137-212/404.0
SDAMHRAFLRHDRALFADNKVRLDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPIlpQERTRIRN
  |.  |||. |  .  ...   .. | |  ..||        | ||||..|.| ...    .|. |    || |...
iGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPe..teRqRlqe

subfamily_PDP_pd Subfamily PDP 124-271 2.2e-14 46.4 In-house 142-316 (398) alignment
Range on Protein: 124-271
Range on HMM: 142-316/398.0
FADNKVRLDNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLA---F--QTRDHKPILPQERTRIRNAG------GFVINGRVDGGLAISRAFGDFDYK
  .....   || ... .|...|.    | ||.|..|..  . .       ..|.    ..| .||...         . |||. | |. .|||||. ||
slreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryK

RNPQLGA--LEQ---------------KVVADPDVTLVErDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSP
 . .|    ||.                . |.|.||  .   |.| ||.|  ||..|..|| .... |   | .. 
wseelqkkvlekaylkvlepkdyktPPYltaePevtshk.lrendkFLvlatDGLwdllsneevvslVgehlakkk

subfamily_PPM1G_pd Subfamily PPM1G 132-301 1.1e-43 142.9 In-house 294-470 (473) alignment
Range on Protein: 132-301
Range on HMM: 294-470/473.0
DNSGGTCTSVLVSPTHYIFVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVI-NGRVDGGLAISRAFGDFDYKRNPQLGALEQKVVADPDV
 .|| | . .|.   . |  | ||||. |.| ||      ||||. ..|..||..||| |  .|||.||| .|||.||. ||.| .|.. || . | ||.
edsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDi

TLVErDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPDN-PKAVCQALLKRCLELGS------RDNMSACLVVF
   .   |.|.|| | ||||..||.    . || .||. . ..  ......||  ||           |||.. .|..
kvlt.lteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll

subfamily_PP2D1_pd Subfamily PP2D1 144-268 9.4e-17 53.9 In-house 187-307 (492) alignment
Range on Protein: 144-268
Range on HMM: 187-307/492.0
SPTHYIfVNLGDSRSLLCRGGKLAFQTRDHKPILPQERTRIRNAGGFVI----NGRVDGGLAISRAFGDFDykrNPQlgaLEQKVVADPDVTLVERDlEH
. . ||  | |. . .|||.||    ||.| |  ..||||...||. |     ||.|.| |   |  | .    .|.   |.. |. .| .| |. | |.
lgvlyi.anaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG...dpk...LkksvipePkttsvkld.ea

DDFLLLCCDGIFDVMSNATAIKFVATKLR
. ||.|   |...|.|.   .. | . |.
aqflvlAsnGlWevlseeevlsLvkqtla

subfamily_PPM1H_pd Subfamily PPM1H 195-273 3.4e-07 22.4 In-house 276-358 (404) alignment
Range on Protein: 195-273
Range on HMM: 276-358/404.0
RVDGGLAISRAFGDFDYKRNPQLGALEQKVVADPDVTL---VERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPD-N
|. . ....| .|| . |   .   .   . . |.|.     . . ..|| |.|  ||..||.|| .. . |.  | . .. .
RllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskveped

subfamily_PPM1D_pd Subfamily PPM1D 200-301 8.4e-10 31.2 In-house 201-307 (309) alignment
Range on Protein: 200-301
Range on HMM: 201-307/309.0
LAISRAFGDFdYKRNPQLGalEQKVVADPDVTLVERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRS---PDNPKAVCQALLKRCLELGSR-----
||..|. ||. .  | . |  |  |  .|||. ...| ....|..|  ||...|.. ..|...| ..   .    .. . | .||.|. |.  ..     
LavaRslGDl.Wsynaksg..efvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNMSACLVVF
||.|. .|..
Dnvsvivvil

SpoIIE Stage II sporulation protein E (SpoIIE) 213-294 1.5e-06 20.2 Pfam-A 102-185 (193) alignment
Range on Protein: 213-294
Range on HMM: 102-185/193.0
RNPQLGALEQkvvadPDVTLVERDLEHDDFLLLCCDGIFDVMSNATAI----KFVATKLRRSPDNPKAVCQALLKRCLELG---SRDNM
... || |..      |.. .| .|| .| |||. ||... .. .. .    .. |.  ... ........||....||||    .| .
tglplGilpe.....adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveellelgsgeleDDi

SpoIIE Stage II sporulation protein E (SpoIIE) 213-294 1.5e-06 20.2 In-house 102-185 (193) alignment
Range on Protein: 213-294
Range on HMM: 102-185/193.0
RNPQLGALEQkvvadPDVTLVERDLEHDDFLLLCCDGIFDVMSNATAI----KFVATKLRRSPDNPKAVCQALLKRCLELG---SRDNM
... || |..      |.. .| .|| .| |||. ||... .. .. .    .. |.  ... ........||....||||    .| .
tglplGilpe.....adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveellelgsgeleDDi

PPM_PTC7_SpoIIE_motif 233-299 8e-09 29.1 In-house 5-78 (81) alignment
Range on Protein: 233-299
Range on HMM: 5-78/81.0
VERDLEHDDFLLLCCDGIF-------DVMSNATAIKFVATKlrrSPDNPKAVCQALLKRCLELG---SRDNMSACLV
.| .|. .| |||..||..       ..... ........    .  ... ....|....||.|   ..|...  ..
aefqLkpgdvllLyTDGltEardsdgelfgkeellrladra...egkslqeladklvdevlengsgereDDitllvl

subfamily_PPTC7_pd Subfamily PPTC7 234-297 9.6e-06 18.2 In-house 161-224 (252) alignment
Range on Protein: 234-297
Range on HMM: 161-224/252.0
ERDLEHDDFLLLCCDGIFDVMSNATAIKFVATKLRRSPDNPKAVCQALLKRCLELGSRDNMSAC
. .....| ..|  ||.|| ... . .....    ..... . ....| ..  ||.   .... 
sfavkkgDiivlatDGlfDNlledeileilkelkeseksslqslakklaekarelsldpeyesp

PPM_PTC7_motif 244-294 5.8e-10 32.5 In-house 1-51 (51) alignment
Range on Protein: 244-294
Range on HMM: 1-51/51.0
LLCCDGIFDVMSNATAIKFVATKLRRSPDNPKAVCQALLKRCLELGSRDNM
.|..||..||.|. .|. .|   |    . |  ... | ...|. || ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni