Gene PPM1A-3 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP130_AA protein Get Run
MbreP130_AA_3-293 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 4-293 5.5e-75 244.8 In-house 3-293 (295) alignment 
Range on Protein: 4-293
Range on HMM: 3-293/295.0
FLDKPKYEKETHHNQGNNLIWALSSMQGWRVEMEDAHQAVTDIPE-LPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEDKLNPDMLKDAFRQ
.|..|..|. ... . ..| .. .|.||.| ..|||. .|....  |.....|.|||||||.......    ....||        . |.......|.|.
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrk

GLLDLDASIRATNSDlDSCADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAVSRSLGDYFY
..| .|  ..... . ..  ..||.||| ...........|.|||||...||| .|. | ||||.|| |..||..|.| ||.|||.|.|||.|.|||...
aflaadeellelall.rpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KDMPDLDATAQKISPEADMTVIERN-PEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLHLDSKDNMSAILVLFENA
| .. | .. . .|.| |.||.|.. ..|.|.|.|.||..|||.|  ....... |. |. .||..|.|.|..|.  |.||.....| ... 
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
subfamily_PPM1G_pd Subfamily PPM1G 4-115 1.4e-22 73.3 In-house 1-103 (473) alignment 
Range on Protein: 4-115
Range on HMM: 1-103/473.0
FLDKPKYEKETHHNQGNNLIWALSSMQGWRVEMEDAHQAVTDIPElpGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEdklnpdmLKDAFRQG
.|.||| |||....  ..| .. |.||||||..||||...||. |    |.|||.|||||  |.| . .  .. . ..  .|. .       .. |... 
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaqkgykegd.......vekaleea

LLDLDASIRATN
 |.||....| .
flalDeklkaee
subfamily_PPM1G2_pd Subfamily PPM1G2 5-290 2e-75 246.4 In-house 2-286 (287) alignment 
Range on Protein: 5-290
Range on HMM: 2-286/287.0
LDKPKYEKETHHNQGNNLIWALSSMQGWRVEMEDAHQA---VTDIPELPGGSFFAVFDGHGGDTVSKICGTDSLKAILEtdifkaaEDKLNPDMLKDAFR
|..|  .||..  . ..   . |.|||.|..|||||     . . .. .  ..|||||||||..|.| .|..  | | .        .... ..|. ...
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.......kksfkegaleqilk

QGLLDLDASIRATnSDLDScaDRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAVSRSLGDYF
...|..| ...   . |.   . .||||| |... .... .|.||||| .. .|||   . ||||..|.|  ||.||.| |...||.||||.||.|||. 
dafletDeellkd.eklkd..esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfe

YKDMPDLDATAQKISPEADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLHLDSK------DNMSAILVLF
.|.   . .  | .  . |..| .....| |...|||||.|||||..   .. ..|. | | .|..|.||| ||  ||.      |||....| .
fkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
subfamily_PPM1A_pd Subfamily PPM1A 12-291 9.4e-113 369.2 In-house 2-281 (282) alignment 
Range on Protein: 12-291
Range on HMM: 2-281/282.0
KETHHNQGNNLIWALSSMQGWRVEMEDAHQAVTDIPELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFK-AAEDKLNPDMLKDAFRQGLLDLDAS
| .....||.| ...||||||||||||||..|.....|...|||||||||.|..|.|.. .  |..|||.. .| ||... . | .|.|.|||.|.|| .
kpksqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldea

IRATNSDLDSCaDRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAVSRSLGDYFYKDMPDLDA
||....||... |.||||||.|.|...|.|. |.|||||..||||...|.|.||||... |  ||..|.| | ..||.|.|||||.||||.||......|
irelstdlkta.dksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekka

TAQKISPEADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLHLDSKDNMSAILVLFE
. |..|.|...|.|||. ||.|...|||||.|||............|......|||...|.|..|. .|.||.|...|||.
eeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
PP2Cc_SM00332 15-288 1.9e-72 236.9 In-house 3-274 (274) alignment 
Range on Protein: 15-288
Range on HMM: 3-274/274.0
HHNQGNNLIWALSSMQGWRVEMEDAHQAVTDIPELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEDklnPDMLKDAFRQGLLDLDASIRAT
 ......|....|||||||..|||||. |.|  |  ...||.|||||||. |.|..     .|. |.  .|. |.    |. ..| ....|..|  |.. 
esgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...eddveealkkaflstdeeilee

NSDLDSCADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAVSRSLGDYFYKDMPdlDATAQK
.. .     .|||||| ....  .... |.|||||..||||..|  . |||| .| |..|||.| | |. ||| |.|||||..||.|.|.      . . 
eqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepy

ISPEADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGY--KAEEVVERLLDYCLHL-DSKDNMSAILV
|..| |..|.. ..||.|...|.||..|||.|  .  .....|. |   ...|. |.| ....    |.||.....|
itaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 21-290 2.7e-39 128.0 In-house 5-253 (255) alignment 
Range on Protein: 21-290
Range on HMM: 5-253/255.0
NLIWALSSMQGWRVEMEDAHQAVTDIPELPGGSFFAVFDGHGGDTVSKICgTDSLKAILETdIFKAAEDklNP-DMLKDAFRQGLLDLdasiratnsdlD
 .. . | | | |  |||   .     . ..  ..|.||||||.. .|.. .. |. ||.  .... .   || ..||.|...  . .           .
rfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfa.seelykilae.lldlnna..nPvkslkkaykeistqi...........s

SCADRSGSTAVGVIVTPTHVIFGNCGDSRAFIC-RNGNVVFATDDHKPTNEGEVARIKAADGDVSMG----RVCGNLAVSRSLGDYFYKDMpdldataqk
  . . |.||. |...  .|.  | ||||. .| ..|  .  . ||||..| |  ||... | |  .    || |.|||||.||| | .           
erpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePf.........

ISPEADMT-VIERNPEDQFMLIACDGIYDVLTNANAAAFITNQlkagYKAEEVVERLLDYCLHLDSKDNMSAILVLF
. |. |..  .|   .|.|...|||||.|.... .|   . .      ..|. .|.| |.  .  |.||.| |.. .
vvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagi....sdpekaaeklrdlayssGstdnisvivikl
0049733 PP2C-like 24-291 6.8e-52 169.0 In-house 5-234 (235) alignment 
Range on Protein: 24-291
Range on HMM: 5-234/235.0
WALSSMQGW-RVEMEDAHQAvtdipelpGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFkaaedkLNPDMLKDAFRQGLLDLDASIRATNSDLDsCA
.. .|..|. | ..|||. .        |...|||.|||||  .....    ....||          |..  |..|.|. .| ... ..... .     
vgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalasp.el

DRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVsmgRVCGNLAVSRSLGDYFYKdmpdldataqkispeADMT
...|.||| ..... .... |.|||||...|.|..|. | ||.|.|| |..||..|.| |   || | ||..|.|||...|               .|.|
agmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvt

VIERNPEDqFMLIACDGIYDVLTNANAAAFITNqlkagYKAEEVVERLLDYCLHLDSKDNMSAILVLFE
|.| .|.| |.|.|.||..|||..  .......     . .||..|||....|.  ..||.....| ..
vlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld
subfamily_PPM1L_pd Subfamily PPM1L 26-292 1.8e-35 115.5 In-house 9-268 (269) alignment 
Range on Protein: 26-292
Range on HMM: 9-268/269.0
LSSMQGWRVEMEDAHQAVTDIPELPGGSFFAVFDGHGGDTVSKICGTdSLKAILETDIFKAAEDKLNPD--MLKDAFRQGLLDLDASIRatnSDLDSCAD
  |..| | .|||  .  .|| .  | |||||||||||.. .. .    |   . . . . ..|| |      .  . . .| .|  .      . .  |
vysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakd.vlvkaiknklieldadkentepinfsklltdeilsvdekll...ekakraed

RSGSTAVGVIVTPTHVIFGNCGDSRAFIC-RNGNVVFATDDHKPTNEGEVARIKAADGDVSM---GRVCGNLAVSRSLGDYFYKDMPDLDATAQKISPEA
 .|.||.  .|. ...|  | ||||  .. ..|. .  . |||| .  |  ||| | | ...    || | ||.||.||||  ||   . |. . .. . 
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdl

DmtviERNPedQFMLIACDGIYDVLTNANAAAFITNQLKAG-YKAEEVVerllDYCLHLDSKDNMSAILVLFEN
|    ...|  .|...|.||..| ..| .|  || ..||   . |  .|      . .  | ||.. ..| ..|
d....dhkp..eflilasdGlwdtfsneeavrfikerlkepdfGakslv....lesfkrGsvdnitvlvvklkn
subfamily_PPM1D_pd Subfamily PPM1D 26-291 5.4e-26 84.4 In-house 6-308 (309) alignment 
Range on Protein: 26-291
Range on HMM: 6-308/309.0
LSSMQGWRVEMEDAHQAVTDI-PEL--PGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEDKLNPDMLKDAFRQGLLDLDASIRATNSDLDSCA
 .. || |  |||  . |..  ...   . .|.||||||||   .|      .. | . . | . |..   . ...|| .    .  . .      .   
seadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgll

DRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGN------VVFATDDHKPTNEGEVARIKAADGDVSMG----RVCG---------N--------LAVSR
  .|.||  ||.. ...  .. |||....  . .          |.|||| .  |. ||. . |.|..     ||.          .        |||.|
staGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaR

SLGDYFYKDMpdlDATAQKISPEADMTVIERNPEDQ-FMLIACDGIYDVLTNANAAAFITNQLKAGYKA----EEVVERLLDYCLHLDSK-----DNMSA
|||| .  ..      .  .||| |..| ...|... |...| ||...||| ..|  ..... . ..      ..|...|..  |.  ..     ||.|.
slGDlWsyna...ksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsv

ILVLFE
|.|..|
ivvile
PPM_PTC7 27-283 5.3e-69 225.5 In-house 6-259 (259) alignment 
Range on Protein: 27-283
Range on HMM: 6-259/259.0
SSMQGWRVEMEDAHQAVTDIP---ELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEdklnpdMLKDAFRQGLLDLDASIRATN-SDLDsCA
|..||.|..||||| |  .          .||||||||||....|.....  ... |   |.  |       |..|.| . | ||. .. .. .. .   
safqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele......klekalrksflaldtdeelksseant.ep

DRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVV-FATDDHKPTNEGEVARIKAADGDVS---MGRVCGNLAVSRSLGDYFYKDMPDldaTAQKISPE
..|||||| ...|...... |.||||| .||.||.| . | ||||.|| |..||..|.| ||   .|||.|.|||||..||...|. .    . |..|.|
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsae

ADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGyKAEEVVERLLDYCLHLDSKDNM
 | .......||.|...|.||..||...  |. .....|... ...|. |.|.|...  .|.||.
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 27-283 6e-69 225.4 Pfam-A 6-255 (255) alignment 
Range on Protein: 27-283
Range on HMM: 6-255/255.0
SSMQGWRVEMEDAHQAVTDIP---ELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEdklnpdMLKDAFRQGLLD-LDASIRAtNSDLDsCA
|..||.| .||||| |  .          .||||||||||. ..|.....  . . | . |. .|       ...|.|.. |  .| ...  ... .   
selqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelks.skant.ep

DRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVV-FATDDHKPTNEGEVARIKAADGDVS-MGRVCGNLAVSRSLGDYFYKDMPdldatAQKISPEAD
..|||||| .......... |.||||| .||..| . . | ||||..| |..||..|.| || .|||.|.|||||.|||...|. .      | .|.| |
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

MTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLHLDSKDNM
.|......||.|...|.||..|||..  |. .....|.......|. |.|.|...   |.||.
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 27-283 6e-69 225.4 In-house 6-255 (255) alignment 
Range on Protein: 27-283
Range on HMM: 6-255/255.0
SSMQGWRVEMEDAHQAVTDIP---ELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEdklnpdMLKDAFRQGLLD-LDASIRAtNSDLDsCA
|..||.| .||||| |  .          .||||||||||. ..|.....  . . | . |. .|       ...|.|.. |  .| ...  ... .   
selqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelks.skant.ep

DRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVV-FATDDHKPTNEGEVARIKAADGDVS-MGRVCGNLAVSRSLGDYFYKDMPdldatAQKISPEAD
..|||||| .......... |.||||| .||..| . . | ||||..| |..||..|.| || .|||.|.|||||.|||...|. .      | .|.| |
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

MTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLHLDSKDNM
.|......||.|...|.||..|||..  |. .....|.......|. |.|.|...   |.||.
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
subfamily_PPM1E_pd Subfamily PPM1E 27-291 1.9e-44 144.8 In-house 9-263 (265) alignment 
Range on Protein: 27-291
Range on HMM: 9-263/265.0
SSMQGWRVEMEDAHQAVTDIPELPG------GSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKaaEDKLnpdmlkDAFRQGLLDLDASIRATNsDLDS
 .... |  ||| | |. |. || .       .||||||||||   .|   .   . . .   .|  || .      .|.....  .| .. ..    ..
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklk..edpa......ealkeafkltDerflqka.erek

CadRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSM---GRVCGNLAVSRSLGDYFYKDMpdldataqkISP
   .|||||| |...  ..  .  |||.|...|.|..|  .. ||| .| | .||..|.| | .    || |.|.|||..||. .|..         .| 
l..ksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpy.........vsg

EADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGY-KAEEVVERLLDYCLHLDSKDNMSAILVLFE
|||.. .| . .......||||..||... ..   ... |. |  . .|| . |..   . .|.||.....|...
eadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfld
PPM_PTC7_SpoIIE 27-274 7.9e-34 110.4 In-house 6-221 (230) alignment 
Range on Protein: 27-274
Range on HMM: 6-221/230.0
SSMQGWRVEMEDAHQAVTDI---PELPGGSFFAVFDGHGGDTvsKICGTDSLKAILETDiFKAAEdklnpdmlkdafrqgllDLDASIRATNSDL-DSCA
|..||.| .||||| .  .    ..   . .....|||||.   . . .   .|. |   |. .|                 .... .|..|  | .   
saaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle.................kpeeilrrlnlalaadle

DR---SGSTAVGVIVTPTH--VIFGNCGDSRAFICRNgNVVfatddhkptnegEVARIkAADGDVS----MGRVCGNLAVSRSLGDYFYKDmpdldaTAQ
|.   ||.||| ....|..  . . |.|||.....|. .              |. || .| | .|     ||| |.||||.. ||.....      | .
depsssgaTavvalidpstgklyvanaGdsppllvrd.dgg............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDG

KISPEADmTVIERNPE-DQFMLIACDGIYDVLTNANAAAFITNQLKAGykaeeVVERLLDYC
 ...|.| |. .. .. |.|. .|.||..|||... .. .. ..|..      . |.||...
vveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDD
subfamily_PPM1K_pd Subfamily PPM1K 27-291 4.3e-31 101.0 In-house 9-259 (263) alignment 
Range on Protein: 27-291
Range on HMM: 9-259/263.0
SSMQGWRVEMEDAHQAVTDIPELpggSFFAVFDGHGGDTVSKICGtDSLKAILETdiFKAAEDKLNpDMLKDAFRQGLLDLDASIRATNSDLdsCADRSG
 |..| | | ||  .     |||    ..||||||.| .  . .  | |. ||..  ..  |..|.  .||.|| .   .|   .. . ..       ||
dsliGkraenedriklkeldpel...lyvavfdGhaGsaaadfvh.dklekilkr..llekekdle.ivlknafeeldkklkrylefsvaea..ellssG

STAVG-VIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSM-----GRVCGNLAVSRSLGDYfykdmpDLDATAQKISPEAD
.||   ..   |...  . ||||| .||||.    |.||.|  | |  |||||.| |..      .| | ||..|||||       ||        ||. 
ttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdl......dlkryGviatPetk

MTVIERNpEDQFMLIACDGIYDVLTNANAAAFITNqlkaGYKAEEVVERLLDYCLHLDSKDNMSAILVLFE
.  .. . .| |...  ||| .|... . . ...       . ||  . | .  |   |.|| .|..| . 
slkvdha.adsflvlitdgisfvvnsqelcdlvrl....chdpeeaahalteqalqygsednatavvvplg
subfamily_ILKAP_pd Subfamily ILKAP 29-266 3.5e-34 111.3 In-house 12-252 (293) alignment 
Range on Protein: 29-266
Range on HMM: 12-252/293.0
MQGWRVEMEDAHQAVTDIP--------ELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETdIFKaAEDKLNPDMLKDAFRQGLLDLDASIRATNSDlDS
 .| | ||.|||  . |.          .   |..||||||.|.  |. .     | |||. . |  . . .   .| .. .     |    .. |  . 
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek.lpk.sdvsakekeikkclvdsfkktdeefLklask.ak

CADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRN---GN---VVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAVSRSLGDYFYKDMpdldataqK
 . . ||||. |.|    .  .| |||.|...|.   |.   .|  | ||.|... |  ||. | | |  ||| | | ||||.||  .| .         
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrl........G

ISPEADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEV
..   |.. .| .. |.|...||||...|... ... ||...|.. .. ...
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrki
subfamily_PP2D1_pd Subfamily PP2D1 32-83 5.6e-07 21.6 In-house 13-63 (492) alignment 
Range on Protein: 32-83
Range on HMM: 13-63/492.0
WRVEMEDAHQAVTDIPELPGGSFFAVFDGHGGDTVSKICGTDsLKAILETDI
|. .|||... . .  . .  .||...||. | |  .|. .. |. .|  ..
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaake.lhevlleel
PP2C_SIG_SM00331 45-288 4.4e-09 29.2 In-house 22-215 (217) alignment 
Range on Protein: 45-288
Range on HMM: 22-215/217.0
DIPELPGG-SFFAVFDGHGGDTVSKICGTDSLKAIlETDIFKAaedklnpdmlkDAFRQGLLDLDASIRATnsdlDSCADRSGSTAVGVI-VTPTHVIFG
|. .|..|  ...|.||.|..  .  .    ..|. .. . .            ... | |  |.  |..     . . ..  .  ....  .  .. . 
dvvklnegrlllvvaDgmGkGlaAaaassqlrtal.rellseg...........eelsqalkrlnraiyee....keekgmfaTlllalydfssgklsya

NCGDSRAFICRNGNVVFATDDhkptnegevarikaadgdvsmgrvcgnlavsrslgdyfykdmP-----------DldataqkispeADMTVIERNPeDQ
|.|||| .. |.|. |. ..|                                          .           .           .|.. .| .. . 
naGdsrpyllrdgklveilkd..........................................vegaplGlepevs...........vdirelelek.gd

FMLIACDGIYDVLTNAN-----AAAFITNQLkaGYKAEEVVE----RLLDYCLHLDSKDNMSAILV
..|.. ||. .. . ..        ...  .  .  |.|. .    .|| .      .|... ..|
llllytDGltearsekgfaeerleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvvv
PP2C_2 Protein phosphatase 2C 46-259 2e-10 33.3 Pfam-A 18-197 (212) alignment 
Range on Protein: 46-259
Range on HMM: 18-197/212.0
IPELPGGSFFAVFDGHGGDTVSKICGTDSLKAIleTDIFKAAEDKLNPDMLKDAFRQGLLDLDASI----RATNSdlDSCADRSGSTAVGVIVTPTHVIF
| |  .|...|| ||.| .  |..      .|.  .. ...  .. ...  ....|| . ...||.    .|  .  .. ..  ..| . ...||....|
ireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivf

GNCGDSRA-FICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMgrvcgnlavsrslgdyfykdmpdldataqkispeaDMTVIERNPEDQFmLIACDGI
...||... .. |.|.|  ......   ..|. ... .|   ..                                   ..  ....| | . |.  ||.
fqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...................................rirrlklepgdal.llmTDGv

YDVLT-NANAAAFITNQLKA
 | |. ... .......|..
sdslrkeepfrellaellet
PP2C_2 Protein phosphatase 2C 46-259 2e-10 33.3 In-house 18-197 (212) alignment 
Range on Protein: 46-259
Range on HMM: 18-197/212.0
IPELPGGSFFAVFDGHGGDTVSKICGTDSLKAIleTDIFKAAEDKLNPDMLKDAFRQGLLDLDASI----RATNSdlDSCADRSGSTAVGVIVTPTHVIF
| |  .|...|| ||.| .  |..      .|.  .. ...  .. ...  ....|| . ...||.    .|  .  .. ..  ..| . ...||....|
ireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivf

GNCGDSRA-FICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMgrvcgnlavsrslgdyfykdmpdldataqkispeaDMTVIERNPEDQFmLIACDGI
...||... .. |.|.|  ......   ..|. ... .|   ..                                   ..  ....| | . |.  ||.
fqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...................................rirrlklepgdal.llmTDGv

YDVLT-NANAAAFITNQLKA
 | |. ... .......|..
sdslrkeepfrellaellet
subfamily_KAPP-like_pd Subfamily KAPP-like 53-288 1.3e-25 82.9 In-house 35-264 (266) alignment 
Range on Protein: 53-288
Range on HMM: 35-264/266.0
SFFAVFDGHGGDTVSkicgtDSLKAILETDIFKAAEDKLNPDMLKDAFRQGLLdLDASIRATNSDLDSCaDRSGSTAV-GVIVTP---THVIFGNCGDSR
..||||||| |  ..     |. | ...  . |  .   . |  .. . |  | |. ...  .. |.   .  |.||   .. .     ..  .| ||| 
alfavfdGhaGkGaa.....daakklfpkelekllkstkqddGGdniydqskl.lenafkevdaklkdf.eyeGatatlalvwsdGqqrylqvanvGdss

AFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGN-LAVSRSLGDYFYKDMPDLDATAQKISPEADMTviernPEDQFMLIACDGIYDVLTNA
||..|  . .. . ||| ... |  |||     .| ..   | |||||.|||.| |..    ..   .|..  .|     | |.|...| ||..||..  
aflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGlisepyvsnrillt.....pfdkflivasdGlwdvisGk

NAAAFITNQLKAGYKAEEVVERLLDYCLH-LDSKDNMSAILV
.|   .      .  .... . ||.  ..   .|||.| |.|
daiekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 53-288 5.3e-22 71.0 In-house 34-274 (276) alignment 
Range on Protein: 53-288
Range on HMM: 34-274/276.0
SFFAVFDGHGGDT----VSKICGtDSLKAILETDIFKAAEDKLNPDMLKDaFRQGLLDLDASIRATNSDLdscaDRSGSTAVG-VIV---------TPTH
..||||||| |       .|.   . |. .|..  .  ....   |   |  .. ||||   . |  .|     .  |.||   ..             .
alfavfdGhaGkGaadaakklfp.kelekllksgnysltkqddGGdniyd.qskllldlfkevdaklkdf....eyeGatatlalvwsdGeeqqqqqqry

VIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCG-NLAVSRSLGDYFYKDMPDLDATAQKISPEADMTviernPEDQFMLIAC
.  .| ||| ||..|  . .. . ||| |.  |. |||     .| ..     |||||.|||.| |..    ..   .|..  .|     | |.|...| 
lqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGlisepyvsnrillt.....pfdkflivas

DGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLH-LDSKDNMSAILV
||..||..  .|   .      .  .... . ||.  ..   .|||.| |.|
dGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 54-189 2.1e-14 46.8 In-house 22-155 (292) alignment 
Range on Protein: 54-189
Range on HMM: 22-155/292.0
F-FAVFDGHG--GDTVSKICGTDslkaiLETDIFKAAEDKlnpDMLKDAFRQGLLDLDASIRATNSDldsCADRSGSTAVGVIVTPT-HVIFGNCGDSRA
|  ||.||||  || |...         || .. .   ..     | .|. ...||. | .. .  |      ......|  .|     .|  | |||||
flaavldGhGvnGdkvaqlaedt.....levelleltrql...qelsealllrildiaakldkltid...aresattavvcarvrddralilanvGdsra

FICR-----NGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCG
 . |     . ...  . |||| . .| |||..| | |   || |
llgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrg
subfamily_PDP_pd Subfamily PDP 95-269 3.8e-17 55.5 In-house 114-324 (398) alignment 
Range on Protein: 95-269
Range on HMM: 114-324/398.0
MLKDAFRQGLLDLDASI--RA----TNSDLDS--CADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRN---GNV--VFATDDHKPTNEGEVARIKAAD--
..|.| ... |.||  |   |    ....|..   .  ||..|. . . .|..   | ||.|| ....   |..  |  . |.  .|| || |||..   
kvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPg

-GD---VSMGRVCGNLAVSRSLGDYFYKDMPDLDAT------AQKISP-----------EADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLK
  .   .  ||. |.|. .|  ||. ||   .|. .       . . |           | ..|  . ...|.|...| ||..|.|.| ...  ... |.
eesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehla

AGYKAEEVVER
   ..|.|  .
kkkekepvkve
subfamily_PPM1H_pd Subfamily PPM1H 96-170 6.4e-07 21.4 In-house 136-207 (404) alignment 
Range on Protein: 96-170
Range on HMM: 136-207/404.0
LKDAFRQGLLDLDASIRAtnsDLDSCADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEG
.. |. .  |..|  |.    . ..  .. | ||. ..|    .   | ||||| ..|.....    |. |  | 
viGalesaflemDeqiar...ereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteR
subfamily_PPM1G_pd Subfamily PPM1G 119-292 7.2e-45 146.8 In-house 290-472 (473) alignment 
Range on Protein: 119-292
Range on HMM: 290-472/473.0
DSCADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVS-MGRVCGNLAVSRSLGDYFYKDMPDLDATAQKISP
..    ||.||| ...   ..|  | ||||. ..|||. .    |||| .| | .||..| | |   ||| | | .|| |||..||   .|..  | || 
eepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisA

EADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGY--KAEEVVERLLDYCLHLDSK------DNMSAILVLFEN
  |. | .  .||.|. .|||||..|..  .   |....|| |   . .|.||.||| ||  | .      |||..|.||...
lPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
subfamily_PP2D1_pd Subfamily PP2D1 123-258 7.5e-15 47.6 In-house 175-307 (492) alignment 
Range on Protein: 123-258
Range on HMM: 175-307/492.0
DRSGSTAVGVIVTpTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDV----SMGRVCGNLAVSRSLGDYfyKDmPDLDataQKISPE
. | .. |  ... . .   | |. .| .||.|. .  | .| | |. |  |.. | . |     .|.| | | . | || |   | |.|    . . ||
kesngsevhleel.gvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny..Gd.pkLk...ksvipe

ADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLK
  .| .. . ..||...|  |...||.. . .. ... |.
PkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtla
subfamily_TAB1_pd Subfamily TAB1 124-248 1.4e-10 33.5 In-house 128-264 (333) alignment 
Range on Protein: 124-248
Range on HMM: 128-264/333.0
RSGSTAVGVIVTPTHVIFGNCGDSRAFICR---NGNVVFATDDHKPTNEGEVARIKAADG---DVSMGRVCGNLAVSRSLGDYF----YKDMPDLDATAQ
. |.||| ...   ..   |.||||| ...   . .|.    ||.  || |. |.|        .   .. |.    ||.|||     |||.  | ....
sgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakg

-KISPEADMTVI-ERNPEDQFMLIACDGIYDVLTNAN
  .  | |..   . ..  .|...  ||.|  | ...
ePviaePdiqgaypiddityflvlmSdGvyktLeevt
subfamily_PHLPP_pd Subfamily PHLPP 142-290 2.1e-06 19.8 In-house 110-245 (246) alignment 
Range on Protein: 142-290
Range on HMM: 110-245/246.0
GNCGDSRAFICRNGNVVFATDDHKPTNEgEVARIKAADGDVS-MGRVCGNLAVSRSLGDYFykdmpdldaTAQKISPEADMTVIERNPEDQFMLIACDGI
 . |   | ..|||. .  .  ..  .. |. ||| | . ..  ... | .. .| || .|         .   . |.  .  .  ...| ....  . .
AsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytf.........lfPvvlPkphvrevlLteqdellivGnkal

YDVLTNANAAAFITNQLKAGYKAEevveRLLDYCLHLDSKDNMSAILVLF
..||   .|.  . .. ..   |     .| |     . .|..|.. | .
WevlsideaveavrkeedplvaAk....klvdlaqsygaadsvsvlvvrl
subfamily_PPM1H_pd Subfamily PPM1H 184-260 4e-06 18.8 In-house 274-354 (404) alignment 
Range on Protein: 184-260
Range on HMM: 274-354/404.0
MGRVCGNLAVSRSLGDYFYKDMPDLDATAQKISPEADMTVIE----RNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAG
  |. . ..|.| |||.  | .         .||. ...|..     . ||. ...| ||..|||.| ..|. ... |.. 
kaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskv
Subfamily Dicty-PPM1L-like 189-290 2.1e-06 19.8 In-house 203-303 (305) alignment 
Range on Protein: 189-290
Range on HMM: 203-303/305.0
GNLAVSRSLGDYFYKDMPDldataqkISPEADMTVIeRNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAE-------EVVERLLDYCLHLDSKD
. | .||| ||   | .           ..  . |.  ...|||...| ||...|| . .   .. . |.  .. .       |. ..     .. .|.|
rllkksrskGdknlkelvi.......Pnndspllvv.akanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD

NMSAILVLF
|.  ... .
nitlviikl
PPM_PTC7_motif 234-283 7.9e-11 35.3 In-house 1-51 (51) alignment 
Range on Protein: 234-283
Range on HMM: 1-51/51.0
LIACDGIYDVLTNANAAAFITNQLKAGYKA-EEVVERLLDYCLHLDSKDNM
..|.||..|||..  |  ... ||.. ..  .|. |.| |..|   |.||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni