Gene PPM1A-3 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP130_AA protein Get Run
MbreP130_AA_3-293 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 4-293 5.5e-75 244.8 In-house 3-293 (295) alignment
Range on Protein: 4-293
Range on HMM: 3-293/295.0
FLDKPKYEKETHHNQGNNLIWALSSMQGWRVEMEDAHQAVTDIPE-LPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEDKLNPDMLKDAFRQ
.|..|..|. ... . ..| .. .|.||.| ..|||. .|....  |.....|.|||||||.......    ....||        . |.......|.|.
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrk

GLLDLDASIRATNSDlDSCADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAVSRSLGDYFY
..| .|  ..... . ..  ..||.||| ...........|.|||||...||| .|. | ||||.|| |..||..|.| ||.|||.|.|||.|.|||...
aflaadeellelall.rpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl

KDMPDLDATAQKISPEADMTVIERN-PEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLHLDSKDNMSAILVLFENA
| .. | .. . .|.| |.||.|.. ..|.|.|.|.||..|||.|  ....... |. |. .||..|.|.|..|.  |.||.....| ... 
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl

subfamily_PPM1G_pd Subfamily PPM1G 4-115 1.4e-22 73.3 In-house 1-103 (473) alignment
Range on Protein: 4-115
Range on HMM: 1-103/473.0
FLDKPKYEKETHHNQGNNLIWALSSMQGWRVEMEDAHQAVTDIPElpGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEdklnpdmLKDAFRQG
.|.||| |||....  ..| .. |.||||||..||||...||. |    |.|||.|||||  |.| . .  .. . ..  .|. .       .. |... 
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdlde..dtslfavyDGHGGkevakyvakklpdllkaqkgykegd.......vekaleea

LLDLDASIRATN
 |.||....| .
flalDeklkaee

subfamily_PPM1G2_pd Subfamily PPM1G2 5-290 2e-75 246.4 In-house 2-286 (287) alignment
Range on Protein: 5-290
Range on HMM: 2-286/287.0
LDKPKYEKETHHNQGNNLIWALSSMQGWRVEMEDAHQA---VTDIPELPGGSFFAVFDGHGGDTVSKICGTDSLKAILEtdifkaaEDKLNPDMLKDAFR
|..|  .||..  . ..   . |.|||.|..|||||     . . .. .  ..|||||||||..|.| .|..  | | .        .... ..|. ...
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.......kksfkegaleqilk

QGLLDLDASIRATnSDLDScaDRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAVSRSLGDYF
...|..| ...   . |.   . .||||| |... .... .|.||||| .. .|||   . ||||..|.|  ||.||.| |...||.||||.||.|||. 
dafletDeellkd.eklkd..esaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfe

YKDMPDLDATAQKISPEADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLHLDSK------DNMSAILVLF
.|.   . .  | .  . |..| .....| |...|||||.|||||..   .. ..|. | | .|..|.||| ||  ||.      |||....| .
fkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl

subfamily_PPM1A_pd Subfamily PPM1A 12-291 9.4e-113 369.2 In-house 2-281 (282) alignment
Range on Protein: 12-291
Range on HMM: 2-281/282.0
KETHHNQGNNLIWALSSMQGWRVEMEDAHQAVTDIPELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFK-AAEDKLNPDMLKDAFRQGLLDLDAS
| .....||.| ...||||||||||||||..|.....|...|||||||||.|..|.|.. .  |..|||.. .| ||... . | .|.|.|||.|.|| .
kpksqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldea

IRATNSDLDSCaDRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAVSRSLGDYFYKDMPDLDA
||....||... |.||||||.|.|...|.|. |.|||||..||||...|.|.||||... |  ||..|.| | ..||.|.|||||.||||.||......|
irelstdlkta.dksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekka

TAQKISPEADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLHLDSKDNMSAILVLFE
. |..|.|...|.|||. ||.|...|||||.|||............|......|||...|.|..|. .|.||.|...|||.
eeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa

PP2Cc_SM00332 15-288 1.9e-72 236.9 In-house 3-274 (274) alignment
Range on Protein: 15-288
Range on HMM: 3-274/274.0
HHNQGNNLIWALSSMQGWRVEMEDAHQAVTDIPELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEDklnPDMLKDAFRQGLLDLDASIRAT
 ......|....|||||||..|||||. |.|  |  ...||.|||||||. |.|..     .|. |.  .|. |.    |. ..| ....|..|  |.. 
esgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...eddveealkkaflstdeeilee

NSDLDSCADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAVSRSLGDYFYKDMPdlDATAQK
.. .     .|||||| ....  .... |.|||||..||||..|  . |||| .| |..|||.| | |. ||| |.|||||..||.|.|.      . . 
eqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepy

ISPEADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGY--KAEEVVERLLDYCLHL-DSKDNMSAILV
|..| |..|.. ..||.|...|.||..|||.|  .  .....|. |   ...|. |.| ....    |.||.....|
itaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 21-290 2.7e-39 128.0 In-house 5-253 (255) alignment
Range on Protein: 21-290
Range on HMM: 5-253/255.0
NLIWALSSMQGWRVEMEDAHQAVTDIPELPGGSFFAVFDGHGGDTVSKICgTDSLKAILETdIFKAAEDklNP-DMLKDAFRQGLLDLdasiratnsdlD
 .. . | | | |  |||   .     . ..  ..|.||||||.. .|.. .. |. ||.  .... .   || ..||.|...  . .           .
rfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfa.seelykilae.lldlnna..nPvkslkkaykeistqi...........s

SCADRSGSTAVGVIVTPTHVIFGNCGDSRAFIC-RNGNVVFATDDHKPTNEGEVARIKAADGDVSMG----RVCGNLAVSRSLGDYFYKDMpdldataqk
  . . |.||. |...  .|.  | ||||. .| ..|  .  . ||||..| |  ||... | |  .    || |.|||||.||| | .           
erpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePf.........

ISPEADMT-VIERNPEDQFMLIACDGIYDVLTNANAAAFITNQlkagYKAEEVVERLLDYCLHLDSKDNMSAILVLF
. |. |..  .|   .|.|...|||||.|.... .|   . .      ..|. .|.| |.  .  |.||.| |.. .
vvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagi....sdpekaaeklrdlayssGstdnisvivikl

0049733 PP2C-like 24-291 6.8e-52 169.0 In-house 5-234 (235) alignment
Range on Protein: 24-291
Range on HMM: 5-234/235.0
WALSSMQGW-RVEMEDAHQAvtdipelpGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFkaaedkLNPDMLKDAFRQGLLDLDASIRATNSDLDsCA
.. .|..|. | ..|||. .        |...|||.|||||  .....    ....||          |..  |..|.|. .| ... ..... .     
vgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalasp.el

DRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVsmgRVCGNLAVSRSLGDYFYKdmpdldataqkispeADMT
...|.||| ..... .... |.|||||...|.|..|. | ||.|.|| |..||..|.| |   || | ||..|.|||...|               .|.|
agmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvt

VIERNPEDqFMLIACDGIYDVLTNANAAAFITNqlkagYKAEEVVERLLDYCLHLDSKDNMSAILVLFE
|.| .|.| |.|.|.||..|||..  .......     . .||..|||....|.  ..||.....| ..
vlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld

subfamily_PPM1L_pd Subfamily PPM1L 26-292 1.8e-35 115.5 In-house 9-268 (269) alignment
Range on Protein: 26-292
Range on HMM: 9-268/269.0
LSSMQGWRVEMEDAHQAVTDIPELPGGSFFAVFDGHGGDTVSKICGTdSLKAILETDIFKAAEDKLNPD--MLKDAFRQGLLDLDASIRatnSDLDSCAD
  |..| | .|||  .  .|| .  | |||||||||||.. .. .    |   . . . . ..|| |      .  . . .| .|  .      . .  |
vysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakd.vlvkaiknklieldadkentepinfsklltdeilsvdekll...ekakraed

RSGSTAVGVIVTPTHVIFGNCGDSRAFIC-RNGNVVFATDDHKPTNEGEVARIKAADGDVSM---GRVCGNLAVSRSLGDYFYKDMPDLDATAQKISPEA
 .|.||.  .|. ...|  | ||||  .. ..|. .  . |||| .  |  ||| | | ...    || | ||.||.||||  ||   . |. . .. . 
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdiltfdl

DmtviERNPedQFMLIACDGIYDVLTNANAAAFITNQLKAG-YKAEEVVerllDYCLHLDSKDNMSAILVLFEN
|    ...|  .|...|.||..| ..| .|  || ..||   . |  .|      . .  | ||.. ..| ..|
d....dhkp..eflilasdGlwdtfsneeavrfikerlkepdfGakslv....lesfkrGsvdnitvlvvklkn

subfamily_PPM1D_pd Subfamily PPM1D 26-291 5.4e-26 84.4 In-house 6-308 (309) alignment
Range on Protein: 26-291
Range on HMM: 6-308/309.0
LSSMQGWRVEMEDAHQAVTDI-PEL--PGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEDKLNPDMLKDAFRQGLLDLDASIRATNSDLDSCA
 .. || |  |||  . |..  ...   . .|.||||||||   .|      .. | . . | . |..   . ...|| .    .  . .      .   
seadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgll

DRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGN------VVFATDDHKPTNEGEVARIKAADGDVSMG----RVCG---------N--------LAVSR
  .|.||  ||.. ...  .. |||....  . .          |.|||| .  |. ||. . |.|..     ||.          .        |||.|
staGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaR

SLGDYFYKDMpdlDATAQKISPEADMTVIERNPEDQ-FMLIACDGIYDVLTNANAAAFITNQLKAGYKA----EEVVERLLDYCLHLDSK-----DNMSA
|||| .  ..      .  .||| |..| ...|... |...| ||...||| ..|  ..... . ..      ..|...|..  |.  ..     ||.|.
slGDlWsyna...ksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsv

ILVLFE
|.|..|
ivvile

PPM_PTC7 27-283 5.3e-69 225.5 In-house 6-259 (259) alignment
Range on Protein: 27-283
Range on HMM: 6-259/259.0
SSMQGWRVEMEDAHQAVTDIP---ELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEdklnpdMLKDAFRQGLLDLDASIRATN-SDLDsCA
|..||.|..||||| |  .          .||||||||||....|.....  ... |   |.  |       |..|.| . | ||. .. .. .. .   
safqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele......klekalrksflaldtdeelksseant.ep

DRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVV-FATDDHKPTNEGEVARIKAADGDVS---MGRVCGNLAVSRSLGDYFYKDMPDldaTAQKISPE
..|||||| ...|...... |.||||| .||.||.| . | ||||.|| |..||..|.| ||   .|||.|.|||||..||...|. .    . |..|.|
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsae

ADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGyKAEEVVERLLDYCLHLDSKDNM
 | .......||.|...|.||..||...  |. .....|... ...|. |.|.|...  .|.||.
PdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni

PP2C Protein phosphatase 2C 27-283 6e-69 225.4 Pfam-A 6-255 (255) alignment
Range on Protein: 27-283
Range on HMM: 6-255/255.0
SSMQGWRVEMEDAHQAVTDIP---ELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEdklnpdMLKDAFRQGLLD-LDASIRAtNSDLDsCA
|..||.| .||||| |  .          .||||||||||. ..|.....  . . | . |. .|       ...|.|.. |  .| ...  ... .   
selqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelks.skant.ep

DRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVV-FATDDHKPTNEGEVARIKAADGDVS-MGRVCGNLAVSRSLGDYFYKDMPdldatAQKISPEAD
..|||||| .......... |.||||| .||..| . . | ||||..| |..||..|.| || .|||.|.|||||.|||...|. .      | .|.| |
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

MTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLHLDSKDNM
.|......||.|...|.||..|||..  |. .....|.......|. |.|.|...   |.||.
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 27-283 6e-69 225.4 In-house 6-255 (255) alignment
Range on Protein: 27-283
Range on HMM: 6-255/255.0
SSMQGWRVEMEDAHQAVTDIP---ELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKAAEdklnpdMLKDAFRQGLLD-LDASIRAtNSDLDsCA
|..||.| .||||| |  .          .||||||||||. ..|.....  . . | . |. .|       ...|.|.. |  .| ...  ... .   
selqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele......kvekalrksfladtdeelks.skant.ep

DRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVV-FATDDHKPTNEGEVARIKAADGDVS-MGRVCGNLAVSRSLGDYFYKDMPdldatAQKISPEAD
..|||||| .......... |.||||| .||..| . . | ||||..| |..||..|.| || .|||.|.|||||.|||...|. .      | .|.| |
sksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePd

MTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLHLDSKDNM
.|......||.|...|.||..|||..  |. .....|.......|. |.|.|...   |.||.
vtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

subfamily_PPM1E_pd Subfamily PPM1E 27-291 1.9e-44 144.8 In-house 9-263 (265) alignment
Range on Protein: 27-291
Range on HMM: 9-263/265.0
SSMQGWRVEMEDAHQAVTDIPELPG------GSFFAVFDGHGGDTVSKICGTDSLKAILETDIFKaaEDKLnpdmlkDAFRQGLLDLDASIRATNsDLDS
 .... |  ||| | |. |. || .       .||||||||||   .|   .   . . .   .|  || .      .|.....  .| .. ..    ..
aavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklk..edpa......ealkeafkltDerflqka.erek

CadRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSM---GRVCGNLAVSRSLGDYFYKDMpdldataqkISP
   .|||||| |...  ..  .  |||.|...|.|..|  .. ||| .| | .||..|.| | .    || |.|.|||..||. .|..         .| 
l..ksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpy.........vsg

EADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGY-KAEEVVERLLDYCLHLDSKDNMSAILVLFE
|||.. .| . .......||||..||... ..   ... |. |  . .|| . |..   . .|.||.....|...
eadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfld

PPM_PTC7_SpoIIE 27-274 7.9e-34 110.4 In-house 6-221 (230) alignment
Range on Protein: 27-274
Range on HMM: 6-221/230.0
SSMQGWRVEMEDAHQAVTDI---PELPGGSFFAVFDGHGGDTvsKICGTDSLKAILETDiFKAAEdklnpdmlkdafrqgllDLDASIRATNSDL-DSCA
|..||.| .||||| .  .    ..   . .....|||||.   . . .   .|. |   |. .|                 .... .|..|  | .   
saaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle.................kpeeilrrlnlalaadle

DR---SGSTAVGVIVTPTH--VIFGNCGDSRAFICRNgNVVfatddhkptnegEVARIkAADGDVS----MGRVCGNLAVSRSLGDYFYKDmpdldaTAQ
|.   ||.||| ....|..  . . |.|||.....|. .              |. || .| | .|     ||| |.||||.. ||.....      | .
depsssgaTavvalidpstgklyvanaGdsppllvrd.dgg............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDG

KISPEADmTVIERNPE-DQFMLIACDGIYDVLTNANAAAFITNQLKAGykaeeVVERLLDYC
 ...|.| |. .. .. |.|. .|.||..|||... .. .. ..|..      . |.||...
vveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDD

subfamily_PPM1K_pd Subfamily PPM1K 27-291 4.3e-31 101.0 In-house 9-259 (263) alignment
Range on Protein: 27-291
Range on HMM: 9-259/263.0
SSMQGWRVEMEDAHQAVTDIPELpggSFFAVFDGHGGDTVSKICGtDSLKAILETdiFKAAEDKLNpDMLKDAFRQGLLDLDASIRATNSDLdsCADRSG
 |..| | | ||  .     |||    ..||||||.| .  . .  | |. ||..  ..  |..|.  .||.|| .   .|   .. . ..       ||
dsliGkraenedriklkeldpel...lyvavfdGhaGsaaadfvh.dklekilkr..llekekdle.ivlknafeeldkklkrylefsvaea..ellssG

STAVG-VIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSM-----GRVCGNLAVSRSLGDYfykdmpDLDATAQKISPEAD
.||   ..   |...  . ||||| .||||.    |.||.|  | |  |||||.| |..      .| | ||..|||||       ||        ||. 
ttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdl......dlkryGviatPetk

MTVIERNpEDQFMLIACDGIYDVLTNANAAAFITNqlkaGYKAEEVVERLLDYCLHLDSKDNMSAILVLFE
.  .. . .| |...  ||| .|... . . ...       . ||  . | .  |   |.|| .|..| . 
slkvdha.adsflvlitdgisfvvnsqelcdlvrl....chdpeeaahalteqalqygsednatavvvplg

subfamily_ILKAP_pd Subfamily ILKAP 29-266 3.5e-34 111.3 In-house 12-252 (293) alignment
Range on Protein: 29-266
Range on HMM: 12-252/293.0
MQGWRVEMEDAHQAVTDIP--------ELPGGSFFAVFDGHGGDTVSKICGTDSLKAILETdIFKaAEDKLNPDMLKDAFRQGLLDLDASIRATNSDlDS
 .| | ||.|||  . |.          .   |..||||||.|.  |. .     | |||. . |  . . .   .| .. .     |    .. |  . 
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek.lpk.sdvsakekeikkclvdsfkktdeefLklask.ak

CADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRN---GN---VVFATDDHKPTNEGEVARIKAADGDVSMGRVCGNLAVSRSLGDYFYKDMpdldataqK
 . . ||||. |.|    .  .| |||.|...|.   |.   .|  | ||.|... |  ||. | | |  ||| | | ||||.||  .| .         
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrl........G

ISPEADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAEEV
..   |.. .| .. |.|...||||...|... ... ||...|.. .. ...
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrki

subfamily_PP2D1_pd Subfamily PP2D1 32-83 5.6e-07 21.6 In-house 13-63 (492) alignment
Range on Protein: 32-83
Range on HMM: 13-63/492.0
WRVEMEDAHQAVTDIPELPGGSFFAVFDGHGGDTVSKICGTDsLKAILETDI
|. .|||... . .  . .  .||...||. | |  .|. .. |. .|  ..
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaake.lhevlleel

PP2C_SIG_SM00331 45-288 4.4e-09 29.2 In-house 22-215 (217) alignment
Range on Protein: 45-288
Range on HMM: 22-215/217.0
DIPELPGG-SFFAVFDGHGGDTVSKICGTDSLKAIlETDIFKAaedklnpdmlkDAFRQGLLDLDASIRATnsdlDSCADRSGSTAVGVI-VTPTHVIFG
|. .|..|  ...|.||.|..  .  .    ..|. .. . .            ... | |  |.  |..     . . ..  .  ....  .  .. . 
dvvklnegrlllvvaDgmGkGlaAaaassqlrtal.rellseg...........eelsqalkrlnraiyee....keekgmfaTlllalydfssgklsya

NCGDSRAFICRNGNVVFATDDhkptnegevarikaadgdvsmgrvcgnlavsrslgdyfykdmP-----------DldataqkispeADMTVIERNPeDQ
|.|||| .. |.|. |. ..|                                          .           .           .|.. .| .. . 
naGdsrpyllrdgklveilkd..........................................vegaplGlepevs...........vdirelelek.gd

FMLIACDGIYDVLTNAN-----AAAFITNQLkaGYKAEEVVE----RLLDYCLHLDSKDNMSAILV
..|.. ||. .. . ..        ...  .  .  |.|. .    .|| .      .|... ..|
llllytDGltearsekgfaeerleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvvv

PP2C_2 Protein phosphatase 2C 46-259 2e-10 33.3 Pfam-A 18-197 (212) alignment
Range on Protein: 46-259
Range on HMM: 18-197/212.0
IPELPGGSFFAVFDGHGGDTVSKICGTDSLKAIleTDIFKAAEDKLNPDMLKDAFRQGLLDLDASI----RATNSdlDSCADRSGSTAVGVIVTPTHVIF
| |  .|...|| ||.| .  |..      .|.  .. ...  .. ...  ....|| . ...||.    .|  .  .. ..  ..| . ...||....|
ireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivf

GNCGDSRA-FICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMgrvcgnlavsrslgdyfykdmpdldataqkispeaDMTVIERNPEDQFmLIACDGI
...||... .. |.|.|  ......   ..|. ... .|   ..                                   ..  ....| | . |.  ||.
fqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...................................rirrlklepgdal.llmTDGv

YDVLT-NANAAAFITNQLKA
 | |. ... .......|..
sdslrkeepfrellaellet

PP2C_2 Protein phosphatase 2C 46-259 2e-10 33.3 In-house 18-197 (212) alignment
Range on Protein: 46-259
Range on HMM: 18-197/212.0
IPELPGGSFFAVFDGHGGDTVSKICGTDSLKAIleTDIFKAAEDKLNPDMLKDAFRQGLLDLDASI----RATNSdlDSCADRSGSTAVGVIVTPTHVIF
| |  .|...|| ||.| .  |..      .|.  .. ...  .. ...  ....|| . ...||.    .|  .  .. ..  ..| . ...||....|
ireasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivf

GNCGDSRA-FICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMgrvcgnlavsrslgdyfykdmpdldataqkispeaDMTVIERNPEDQFmLIACDGI
...||... .. |.|.|  ......   ..|. ... .|   ..                                   ..  ....| | . |.  ||.
fqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel...................................rirrlklepgdal.llmTDGv

YDVLT-NANAAAFITNQLKA
 | |. ... .......|..
sdslrkeepfrellaellet

subfamily_KAPP-like_pd Subfamily KAPP-like 53-288 1.3e-25 82.9 In-house 35-264 (266) alignment
Range on Protein: 53-288
Range on HMM: 35-264/266.0
SFFAVFDGHGGDTVSkicgtDSLKAILETDIFKAAEDKLNPDMLKDAFRQGLLdLDASIRATNSDLDSCaDRSGSTAV-GVIVTP---THVIFGNCGDSR
..||||||| |  ..     |. | ...  . |  .   . |  .. . |  | |. ...  .. |.   .  |.||   .. .     ..  .| ||| 
alfavfdGhaGkGaa.....daakklfpkelekllkstkqddGGdniydqskl.lenafkevdaklkdf.eyeGatatlalvwsdGqqrylqvanvGdss

AFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCGN-LAVSRSLGDYFYKDMPDLDATAQKISPEADMTviernPEDQFMLIACDGIYDVLTNA
||..|  . .. . ||| ... |  |||     .| ..   | |||||.|||.| |..    ..   .|..  .|     | |.|...| ||..||..  
aflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGlisepyvsnrillt.....pfdkflivasdGlwdvisGk

NAAAFITNQLKAGYKAEEVVERLLDYCLH-LDSKDNMSAILV
.|   .      .  .... . ||.  ..   .|||.| |.|
daiekvkslydqqatedkmasslletaiqsikakdnvsvivv

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 53-288 5.3e-22 71.0 In-house 34-274 (276) alignment
Range on Protein: 53-288
Range on HMM: 34-274/276.0
SFFAVFDGHGGDT----VSKICGtDSLKAILETDIFKAAEDKLNPDMLKDaFRQGLLDLDASIRATNSDLdscaDRSGSTAVG-VIV---------TPTH
..||||||| |       .|.   . |. .|..  .  ....   |   |  .. ||||   . |  .|     .  |.||   ..             .
alfavfdGhaGkGaadaakklfp.kelekllksgnysltkqddGGdniyd.qskllldlfkevdaklkdf....eyeGatatlalvwsdGeeqqqqqqry

VIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCG-NLAVSRSLGDYFYKDMPDLDATAQKISPEADMTviernPEDQFMLIAC
.  .| ||| ||..|  . .. . ||| |.  |. |||     .| ..     |||||.|||.| |..    ..   .|..  .|     | |.|...| 
lqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGlisepyvsnrillt.....pfdkflivas

DGIYDVLTNANAAAFITNQLKAGYKAEEVVERLLDYCLH-LDSKDNMSAILV
||..||..  .|   .      .  .... . ||.  ..   .|||.| |.|
dGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivv

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 54-189 2.1e-14 46.8 In-house 22-155 (292) alignment
Range on Protein: 54-189
Range on HMM: 22-155/292.0
F-FAVFDGHG--GDTVSKICGTDslkaiLETDIFKAAEDKlnpDMLKDAFRQGLLDLDASIRATNSDldsCADRSGSTAVGVIVTPT-HVIFGNCGDSRA
|  ||.||||  || |...         || .. .   ..     | .|. ...||. | .. .  |      ......|  .|     .|  | |||||
flaavldGhGvnGdkvaqlaedt.....levelleltrql...qelsealllrildiaakldkltid...aresattavvcarvrddralilanvGdsra

FICR-----NGNVVFATDDHKPTNEGEVARIKAADGDVSMGRVCG
 . |     . ...  . |||| . .| |||..| | |   || |
llgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrg

subfamily_PDP_pd Subfamily PDP 95-269 3.8e-17 55.5 In-house 114-324 (398) alignment
Range on Protein: 95-269
Range on HMM: 114-324/398.0
MLKDAFRQGLLDLDASI--RA----TNSDLDS--CADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRN---GNV--VFATDDHKPTNEGEVARIKAAD--
..|.| ... |.||  |   |    ....|..   .  ||..|. . . .|..   | ||.|| ....   |..  |  . |.  .|| || |||..   
kvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPg

-GD---VSMGRVCGNLAVSRSLGDYFYKDMPDLDAT------AQKISP-----------EADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLK
  .   .  ||. |.|. .|  ||. ||   .|. .       . . |           | ..|  . ...|.|...| ||..|.|.| ...  ... |.
eesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehla

AGYKAEEVVER
   ..|.|  .
kkkekepvkve

subfamily_PPM1H_pd Subfamily PPM1H 96-170 6.4e-07 21.4 In-house 136-207 (404) alignment
Range on Protein: 96-170
Range on HMM: 136-207/404.0
LKDAFRQGLLDLDASIRAtnsDLDSCADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEG
.. |. .  |..|  |.    . ..  .. | ||. ..|    .   | ||||| ..|.....    |. |  | 
viGalesaflemDeqiar...ereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteR

subfamily_PPM1G_pd Subfamily PPM1G 119-292 7.2e-45 146.8 In-house 290-472 (473) alignment
Range on Protein: 119-292
Range on HMM: 290-472/473.0
DSCADRSGSTAVGVIVTPTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDVS-MGRVCGNLAVSRSLGDYFYKDMPDLDATAQKISP
..    ||.||| ...   ..|  | ||||. ..|||. .    |||| .| | .||..| | |   ||| | | .|| |||..||   .|..  | || 
eepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisA

EADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGY--KAEEVVERLLDYCLHLDSK------DNMSAILVLFEN
  |. | .  .||.|. .|||||..|..  .   |....|| |   . .|.||.||| ||  | .      |||..|.||...
lPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk

subfamily_PP2D1_pd Subfamily PP2D1 123-258 7.5e-15 47.6 In-house 175-307 (492) alignment
Range on Protein: 123-258
Range on HMM: 175-307/492.0
DRSGSTAVGVIVTpTHVIFGNCGDSRAFICRNGNVVFATDDHKPTNEGEVARIKAADGDV----SMGRVCGNLAVSRSLGDYfyKDmPDLDataQKISPE
. | .. |  ... . .   | |. .| .||.|. .  | .| | |. |  |.. | . |     .|.| | | . | || |   | |.|    . . ||
kesngsevhleel.gvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGny..Gd.pkLk...ksvipe

ADMTVIERNPEDQFMLIACDGIYDVLTNANAAAFITNQLK
  .| .. . ..||...|  |...||.. . .. ... |.
PkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtla

subfamily_TAB1_pd Subfamily TAB1 124-248 1.4e-10 33.5 In-house 128-264 (333) alignment
Range on Protein: 124-248
Range on HMM: 128-264/333.0
RSGSTAVGVIVTPTHVIFGNCGDSRAFICR---NGNVVFATDDHKPTNEGEVARIKAADG---DVSMGRVCGNLAVSRSLGDYF----YKDMPDLDATAQ
. |.||| ...   ..   |.||||| ...   . .|.    ||.  || |. |.|        .   .. |.    ||.|||     |||.  | ....
sgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakg

-KISPEADMTVI-ERNPEDQFMLIACDGIYDVLTNAN
  .  | |..   . ..  .|...  ||.|  | ...
ePviaePdiqgaypiddityflvlmSdGvyktLeevt

subfamily_PHLPP_pd Subfamily PHLPP 142-290 2.1e-06 19.8 In-house 110-245 (246) alignment
Range on Protein: 142-290
Range on HMM: 110-245/246.0
GNCGDSRAFICRNGNVVFATDDHKPTNEgEVARIKAADGDVS-MGRVCGNLAVSRSLGDYFykdmpdldaTAQKISPEADMTVIERNPEDQFMLIACDGI
 . |   | ..|||. .  .  ..  .. |. ||| | . ..  ... | .. .| || .|         .   . |.  .  .  ...| ....  . .
AsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytf.........lfPvvlPkphvrevlLteqdellivGnkal

YDVLTNANAAAFITNQLKAGYKAEevveRLLDYCLHLDSKDNMSAILVLF
..||   .|.  . .. ..   |     .| |     . .|..|.. | .
WevlsideaveavrkeedplvaAk....klvdlaqsygaadsvsvlvvrl

subfamily_PPM1H_pd Subfamily PPM1H 184-260 4e-06 18.8 In-house 274-354 (404) alignment
Range on Protein: 184-260
Range on HMM: 274-354/404.0
MGRVCGNLAVSRSLGDYFYKDMPDLDATAQKISPEADMTVIE----RNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAG
  |. . ..|.| |||.  | .         .||. ...|..     . ||. ...| ||..|||.| ..|. ... |.. 
kaRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskv

Subfamily Dicty-PPM1L-like 189-290 2.1e-06 19.8 In-house 203-303 (305) alignment
Range on Protein: 189-290
Range on HMM: 203-303/305.0
GNLAVSRSLGDYFYKDMPDldataqkISPEADMTVIeRNPEDQFMLIACDGIYDVLTNANAAAFITNQLKAGYKAE-------EVVERLLDYCLHLDSKD
. | .||| ||   | .           ..  . |.  ...|||...| ||...|| . .   .. . |.  .. .       |. ..     .. .|.|
rllkksrskGdknlkelvi.......Pnndspllvv.akanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD

NMSAILVLF
|.  ... .
nitlviikl

PPM_PTC7_motif 234-283 7.9e-11 35.3 In-house 1-51 (51) alignment
Range on Protein: 234-283
Range on HMM: 1-51/51.0
LIACDGIYDVLTNANAAAFITNQLKAGYKA-EEVVERLLDYCLHLDSKDNM
..|.||..|||..  |  ... ||.. ..  .|. |.| |..|   |.||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni