Gene PPM1E in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1E
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP133_AA protein Get Run
MbreP133_AA_109-334 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 108-332 4.1e-45 147.0 In-house 3-214 (255) alignment
Range on Protein: 108-332
Range on HMM: 3-214/255.0
GRRYNIDIFTSRGRRHTMEDRHLAiedlnallgikasWPAVNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDD-PVKALHDGFLACDKMFl
..|...      ||| ||||.  .             . . .| . . ..|..||||| .|||||  .|.|..||    ..  |||.|.. . . . .. 
ssrfkvgfsdmiGrrptmedelvi.............yGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi.

kkSERDaLTCGATAVTVLVRGRKLYVAWLGDSQVAMC-RNGEMVTLMNPHKPEREDEKQRIADNEGVVVWY-GAWRVNGVLSVSRAIGDRKLKQWVIGKP
  |||    .|.||..||. . | |.| .|||.| .| ..|  . |   |||  |.|..||..  | ||    . |||| |.||||.||  |. .|. .|
..serp.kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvvpdP

DIA-EFDITDDCEYLIAGCDGLWDVMNTE
|.  ...|. . ..||  |||.||..  |
dlsqsleiskkdkflilacdGiwdlisde

subfamily_PPM1E_pd Subfamily PPM1E 110-335 9.3e-107 349.1 In-house 3-221 (265) alignment
Range on Protein: 110-335
Range on HMM: 3-221/265.0
RYNIDIFTSRGRRHTMEDRHLAIEDLNALLGIkaswpavNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPVKALHDGFLACDKMFLKKS
 |...|.. ...|..|||||.|.||||.|...       .|......|||.||||||||||.|.|.||.....|...|.||..||...| ..|..||.|.
eyevsiaavknkrrkmEDrhvaledlnelfel.......kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpaealkeafkltDerflqka

ERDALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWYGAWRVNGVLSVSRAIGDRKLKQWVIGKPDIAEF
||..|..|.|||.||.....||||||||||....|.||.|.||.||||||||||.||....|.||..|||||||||||||||||.|||..|.|..|.||.
ereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaev

DITDDCEYLIAGCDGLWDVMNTETVR
......||||..|||||||.|.|.| 
eldgseeylilacDGlwDvvneeevv

0034914 PP2C-like 110-334 9.3e-61 198.2 In-house 20-249 (295) alignment
Range on Protein: 110-334
Range on HMM: 20-249/295.0
RYNIDIFTSRGRRHTMEDRHLAIEdlnallgikaswPAVNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAE--------QPTFKDDPVKALHDGFLAC
.... ... .|||...||..|..             . .........|.| ||||| .||..|.  |.. ..|         ... .|...||...|||.
llrvgvasdqGrrksneDavlvvl............nllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaa

DKMFLKKSER--DALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWygaWRVNGVLSVSRAIGDRKLK--
|. .|.....  . ...|.|||..|.||.|||||..|||.. ..||||.| | . ||| .|.|..|| ...|.|..   .|||||| |.||.||. ||  
deellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh...grvngvlavtRalGdfdlkll

-------QWVIGKPDIAEFDIT-DDCEYLIAGCDGLWDVMNTETV
       ..|.  ||.  ...| .|...|. ..||||||.. |..
lslllleplvsaePdvtvleltledddfllLasDGlwdvlsneei

subfamily_PPM1A_pd Subfamily PPM1A 111-334 4.8e-51 166.7 In-house 12-239 (282) alignment
Range on Protein: 111-334
Range on HMM: 12-239/282.0
YNIDIFTSRGRRHTMEDRHLAIEDLNALlgikaswpavndmPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTF---------KDDPVKALHDGFLAC
. . . . .|.| .|||.| .. .|.||             . .|.|||.|||.| |.||... .|.. | |. ..         ||.  .||..|||| 
lrygvssmqgwrvemEDahtvvaslgal.............kdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLal

DKMFLKKSERDA--LTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVwygAWRVNGVLSVSRAIGDRKLKQ-
|.   ..|..    . .|.|||||||. ..|..| ||||   .||||... | . |||.|..||.|| .  | ||     |||| | ||||.|| ..|. 
deairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv...vsRvnGaLAvsRalGDyeykee

--------WVIGKPDIAEFDITDDCEYLIAGCDGLWDVMNTETV
         |...|... ...... ..|.  |||.|||.. |.|
eekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeev

0049733 PP2C-like 111-334 1.3e-46 151.8 In-house 3-197 (235) alignment
Range on Protein: 111-334
Range on HMM: 3-197/235.0
YNIDIFTSRGR-RHTMEDRHLAiedlnallgikaswpavndmpPQSWFAVMDGHGGVEAAKFAQAQLHKVIAE--QPTFKDDPVKALHDGFLACDKMFLK
...  .. .|| |...||..|.                      ...||| ||||| .|...|  .|.....|  ....  |...||.. |||.....|.
lsvgaasdigrvrkvneDavlv.....................glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaanealle

KSER--DALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVvwygawRVNGVLSVSRAIGDRKLKqwvigkPD
....  .  ..|.|||..|..|.|||||..||| . ..|.|..| |  .|.| .|.|.||| . .|.|      ||.|.| ..||.||. ||      ||
lalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav......rvpgrlaltralGdlllk......pd

IAEFDITDDCeYLIAGCDGLWDVMNTETV
. ........ .|.  .||||||.. |..
vtvlelepgd.flllasDGlwdvlsdeei

subfamily_PPM1L_pd Subfamily PPM1L 111-334 2e-41 135.1 In-house 5-229 (269) alignment
Range on Protein: 111-334
Range on HMM: 5-229/269.0
YNIDIFTSRGRRHTMEDRHLAIEDLNallgikaswpavnDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQP----TFKDDPV-----KALHDGFLAC
 .. ... .|||  ||||    ||..             .   .| |||.|||||  ||.||.  | | | ..     . |.. .     | | |  |. 
qqvavysvlGrrprmedrfeieedik.............nktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsv

DKMFLKKSERDALTCGATAVTVLVRGRKLYVAWLGDSQVAMC-RNGEMVTLMNPHKPEREDEKQRIADNEGVVVWYGAWRVNGVLSVSRAIGDRKLK--Q
|. .|.| .|   . |.||.  ||....| || .|||.  .. ..|. . |   |||..  |..|| .  | . . |.|||.|||..|||.||  ||  .
dekllekakraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdkn

WVIGKPDIAEFDITD-DCEYLIAGCDGLWDVMNT-ETV
 || .|||  ||. | . |.||  .||||| .   |.|
lviadpdiltfdlddhkpeflilasdGlwdtfsneeav

subfamily_PPM1G2_pd Subfamily PPM1G2 114-334 2.7e-51 167.2 In-house 22-239 (287) alignment
Range on Protein: 114-334
Range on HMM: 22-239/287.0
DIFTSRGRRHTMEDRHLAIEDlnallgikasWPAVNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPVK-ALHDGFLACDKMFLKKSERD
   . .| | .||| |.  ..            . .| .  . |||.||||| ..||.|  .|.|.||....||.. .. .|.|.||..|. .||... .
gssamqGyrlnmeDahilene..........lleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkdeklk

ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVwygAWRVNGVLSVSRAIGDRKLKQ---------WVIGK
  ..|.|||.||.. .|||||  |||.  .. .|.. .|   |||..|.||.|| ...|.|      ||||.|..|||.|| . |.          |   
desaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfve...lnrvngnLalsralgDfefkknvkkkpeeqivtav

PDIAEFDITDDCEYLIAGCDGLWDVMNTETV
||.   ....| |.|.  |||.|||.. ..|
PDvlvkkldeddeflvLaCDGiWDvltnkev

subfamily_PPM1D_pd Subfamily PPM1D 115-334 6.9e-30 97.2 In-house 6-257 (309) alignment
Range on Protein: 115-334
Range on HMM: 6-257/309.0
IFTSRGRRHTMEDRHLAIEDL-NALLGIkaswpavndmpPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDP----VKALHDGFLACDKMFLKK-
 ....| |. |||.     .  . .. .            .. .||.||||| ||||||. .| .|| .|  |  ..    ..|....|||. .   || 
seadqGgrkymeDvvaivleeeesaeel...........evafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkl

------SERDALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGE------MVTLMNPHKPEREDEKQRIADNEGVV---------VWYG-AWRVNGV--
       . .  | |.|| .|..|..|||||  |||.. .  . .        .|.. ||||  .||.||..  | |         ||     . ||   
eeWpktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptv

------LSVSRAIGD-----RKLKQWVI-GKPDIAEFDITDDCE-YLIAGCDGLWDVMNTETV
      |.|.|..||      | ...|.  .||. .. .. . | ..| . ||||.|...|..
ideiPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpeda

PPM_PTC7 116-334 2.3e-62 203.8 In-house 6-226 (259) alignment
Range on Protein: 116-334
Range on HMM: 6-226/259.0
FTSRGRRHTMEDRHLAIEDLNALlgikaswpavNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDD--PVKALHDGFLA--CDKMFLKKSER
   .|.|..|||.|.|  .|..           ..  . . ||| ||||| ||||.|. .|.....|...|...  . ||| ..|||   |... .....
safqgfrksmedahialanless..........sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelkssean

-DALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMV-TLMNPHKPEREDEKQRIADNEGVVVWYGAWRVNGVLSVSRAIGDRKLKQ------WVIGK
   .|.|.|||..|..| |||||..|||.. .||.|. | .| . |||..|||..|| .. | | . | .|||||| ||||.|| .||.      .|.  
tepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsae

PDIAEFDITDDCEYLIAGCDGLWDVMNTETV
||| . .|... |.|| ..||||||.. ...
PdisstkideedefliLasdGlwdvvsdqea

PP2Cc_SM00332 116-334 1.1e-58 191.8 In-house 15-232 (274) alignment
Range on Protein: 116-334
Range on HMM: 15-232/274.0
FTSRGRRHTMEDRHLAIEDLNallgikaswpavnDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDD-----PVKALHDGFLACDKMFLKKSE
 .. |.|..|||.|  . ||.                  . |.| ||||| |.|||....|.. ..|.. .|.|     . .||...||..|. .|.. .
ssmqgwrksmeDahvvvvdlv.............eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeq

RDAL---TCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWYgawRVNGVLSVSRAIGDRKLK-------QWV
.  |   ..|.|||..|... .||||..|||.. .||||..| | . ||||.|||..|| .. ||| .    ||||.|.||||.||..||       . .
skelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg...rvngglavsrafGdhflkknkklkepyi

IGKPDIAEFDITDDCEYLIAGCDGLWDVMNTETV
. .||.   ..|.. | ||  .||||||.. ..|
taepdvkvvtltsedeflilaSDGlwdvlsnqev

PP2C Protein phosphatase 2C 117-334 1.4e-62 204.6 Pfam-A 7-221 (255) alignment
Range on Protein: 117-334
Range on HMM: 7-221/255.0
TSRGRRHTMEDRHLAIEDLNALlgikaswpavNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDD--PVKALHDGFLA-CDKMFLKKSER-D
. .|.|..|||.|.|...|..           ..  . . |||.||||| ||||.|. .|.....||..|...    ||| ..|||  |... .....  
elqgarksmedahialknleks..........sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskante

ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMV-TLMNPHKPEREDEKQRIADNEGVVVWygAWRVNGVLSVSRAIGDRKLKQ----WVIGKPDIA
 ...|.|||..|.|| |||||..|||.. .||... . .|.. |||..|||..|| ...| | .   .||||.|.||||.|| .||.    .|. .||. 
psksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvt

EFDITDDCEYLIAGCDGLWDVMNTETV
....|.. |.|| ..||||||.. ...
svklteedefliLasdGlwdvlsdqea

PP2C Protein phosphatase 2C 117-334 1.4e-62 204.6 In-house 7-221 (255) alignment
Range on Protein: 117-334
Range on HMM: 7-221/255.0
TSRGRRHTMEDRHLAIEDLNALlgikaswpavNDMPPQSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDD--PVKALHDGFLA-CDKMFLKKSER-D
. .|.|..|||.|.|...|..           ..  . . |||.||||| ||||.|. .|.....||..|...    ||| ..|||  |... .....  
elqgarksmedahialknleks..........sgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskante

ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMV-TLMNPHKPEREDEKQRIADNEGVVVWygAWRVNGVLSVSRAIGDRKLKQ----WVIGKPDIA
 ...|.|||..|.|| |||||..|||.. .||... . .|.. |||..|||..|| ...| | .   .||||.|.||||.|| .||.    .|. .||. 
psksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn..ngrvngsLavsRalGdfelkpkeeqlvsaePdvt

EFDITDDCEYLIAGCDGLWDVMNTETV
....|.. |.|| ..||||||.. ...
svklteedefliLasdGlwdvlsdqea

PPM_PTC7_SpoIIE 117-332 1.8e-31 102.7 In-house 7-199 (230) alignment
Range on Protein: 117-332
Range on HMM: 7-199/230.0
TSRGRRHTMEDRHLAIEDLNALlgikaswpavNDMPPQSWFAVMDGHGGVEaaKFAQAQLHKVIAEQPtFKDD--PVKALHDGFLACDKMFLKKserdAL
  .|.|..|||.| .  ....           ..      ... ||||| .  ..| ..|.....|.  |..   | ..|....||... . ..      
aaqgarksmedahispanseks..........sggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede....ps

TCGATAVTVLVRGRK--LYVAWLGDSQVAMCRN-GEmvtlmnphkperedEKQRIaDNEGVV-VWYGAWRVNGVLSVSRAIGDRKLKQ---WVIGKPDiA
..||||| .|... .  ||||..||| . ..|. |               |. || .  | . .  . .||.|||.||.|.||. |.     |  .||  
ssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.t

EFDITDD-CEYLIAGCDGLWDVMNTE
. .....  |.||...||||||.. .
sdgelfgkdeflilasdglwdvlspq

subfamily_PPM1G_pd Subfamily PPM1G 117-208 3.1e-12 39.3 In-house 25-102 (473) alignment
Range on Protein: 117-208
Range on HMM: 25-102/473.0
TSRGRRHTMEDRHLAIEDLNAllgikaSWpavndmppqSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPV-KALHDGFLACDKMFLKK
.  | |. .|| | .| ||.        .         | ||| ||||| | ||.  ..| ... .| ..|.. | |||.. |||.|.   ..
amqGwrvsqEDahncitdlde......dt.........slfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklkae

subfamily_ILKAP_pd Subfamily ILKAP 118-334 2e-40 131.8 In-house 12-235 (293) alignment
Range on Protein: 118-334
Range on HMM: 12-235/293.0
SRGRRHTMEDRHLAIEDLNALLGIKASwpAVNDMppqSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPV------KALHDGFLACDKMFLKKSER
 .| |..|.| |. .|||.  |. . |   |. .   |..|| |||.|  |..||. .|||.| |. . .|         |.| | | . |. |||....
rkGereemqdahviledldeqlrleks..lvsrv...syyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklask

D--ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGE------MVTLMNPHKPEREDEKQRIADNeGVVVWYGawRVNGVLSVSRAIGDRKLKQW-VIG
.  .   |.||..|||    |||| ||||.  ..|. |      .|.|   |.| ...|..||    | ||. |  ||.||| |||.||| . |.  || 
akPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqka.Ggvvrdg..rvlGvlevsrsiGdgrfkrlGvis

KPDIAEFDITDDCEYLIAGCDGLWDVMNTETV
.||.   ..|..  ...  |||||.|.... |
tPdvkkceLtendlfvvlaCdGLwkvfsadev

Subfamily Dicty-PPM1L-like 153-333 1.9e-14 46.2 In-house 36-254 (305) alignment
Range on Protein: 153-333
Range on HMM: 36-254/305.0
PQSWFAVMDGHGGVEAAKFAQAQLHKVI------------AEQPTFKDDPVKALHDGFLACDKMFLKKSERDALTCGATA----VTVLVRGRKLYVAWLG
 .| | |.|||.|  ||.... .| ...            |.    .| |..|.....|. || .|. .| |    |.|      .| .   .. |.  .
elslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkkaGttlngssasvilerertivstas

DSQVAMCRNGEMVTLMNPHKPE---------------------REDEKQRIADNEGVVVWYGAWRVNGVLSVSRAIGDRKLKQWVIGKPDIAEFDIT--D
|..|...  .    |   . |                      ..... ||   .. .. ||  .||..|..|| .||. ||. || ..|   . ..  .
dtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvvakan

DCEYLIAgCDGLWDVMNTET
|  ...|  ||||.|.. . 
Dqflvla.tdGlwevlsyqd

subfamily_PHLPP_pd Subfamily PHLPP 154-333 2.3e-19 62.3 In-house 27-207 (246) alignment
Range on Protein: 154-333
Range on HMM: 27-207/246.0
QSWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPVKALHDGFLACDKMFLKKSERdaltCGATAVTVLVRGRK--------LYVAWLGDSQVAMCRN
.. . ..||.  .| ..  |  ...|..|. . . .  . ..  .|.. .   .. |.     |..|. .|.|  |        | ||  |  | ...||
ealyGlfdGdrneelssllqrlmkdvlkeevqkdkneeeymkntllvaqrklGeaGek....lgsaallilirhdkvdPaksfsLevAsvGtlqavliRn

GEMVTLMNPHKPEREdEKQRIADNEGVVVWYGawRVNGVLSVSRAIGDRKLKQWVIGKPDIAEFDITDDCEYLIAGCDGLWDVMNTET
|. ..| .... |.. | .|| ......   .  ..|||.. .| .|   |  .|. || . |  .|.. |.|| | . ||.|.. . 
gkklrlsksyviekd.elkrikeakaiitedn..kingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWevlside

PP2C_SIG_SM00331 154-333 2e-09 30.3 In-house 30-168 (217) alignment
Range on Protein: 154-333
Range on HMM: 30-168/217.0
QSWFAVMDGHG-GVEAAKFAqAQLHKVIAEQPTFKddpvKALHDGFLACDKMFLKKSERDALtcGATAVTV--LVRGRKLYVAWLGDSQVAMCRNGEMVT
.  ..| ||.| |..|| .. .||.... |. . .    ..| . . .... . ...| .    .||..      ...||..| .||| . . |.|..|.
rlllvvaDgmGkGlaAaaas.sqlrtalrellseg....eelsqalkrlnraiyeekeekgm..faTlllalydfssgklsyanaGdsrpyllrdgklve

LMNPhkperedekqriadnegvvvwygawrvngvlSVSRAIGDRKLKQwvigkPDIAEFDITDDCEYLIAgCDGLWDVMNTET
                                     ....|  .  .     .||.|...  .. .|..  |||........
ilkd...............................vegaplGlepevs.....vdirelelekgdlllly.tDGltearsekg

subfamily_PPM1K_pd Subfamily PPM1K 155-333 1.7e-35 115.4 In-house 32-220 (263) alignment
Range on Protein: 155-333
Range on HMM: 32-220/263.0
SWFAVMDGHGGVEAAKFAQAQLHKVIAEQPTFKDDPVKALHDGFLACDKMFLK-----KSERDALTCGATAVTVLVR-GRKLYVAWLGDSQVAMCRNGEM
 ..|| |||.|. ||.|.  .|.|.. .     .|  . |.. |. .|| . .      .|.. |. |.||  .|.| | .| .| ||||.  .||||. 
lyvavfdGhaGsaaadfvhdklekilkrllekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGka

VTLMNPHKPEREDEKQRIADNEGVVVWY--GAWRVNGVLSVSRAIGDRKLKQW-VIGKPDIAEFDI-TDDCEYLIAGCDGLWDVMNTET
  | . |.||.|.||.||   .| | |   |  .|||.|...|..|| .||.. || .|.  ....  ..  .|.   ||. .|.| . 
kkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqe

subfamily_KAPP-like_pd Subfamily KAPP-like 155-332 1.6e-23 76.1 In-house 35-222 (266) alignment
Range on Protein: 155-332
Range on HMM: 35-222/266.0
SWFAVMDGHGGVEAAKFAQAQLHKVIAEQP--TFKDDPVKALHDGFLACDKMFL------KKSERDalTCGATAVTVLVRGRKLY--VAWLGDSQVAMCR
. |||.||| |  ||. |.  . |.. ..   | .||  .  .|     ...|       |. | .   . || . |   |.. |  || .|||   ..|
alfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeye..GatatlalvwsdGqqrylqvanvGdssaflsr

NGEMVTLMNPHKPEREDEKQRIAdNEGVVVWYGAWRVNGVlSVSRAIGDRKLKQWV---IGKPDIA-EFDITDDCEYLIAGCDGLWDVMNTE
  | . |   || . ..|||||  ..|. .  .  |.||.  ||||.||  .|.     |..| .. .. .|   ..||   ||||||.. .
Gneslelskdhkakdpeekqrik.ddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGk

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 155-332 2.8e-19 62.1 In-house 34-232 (276) alignment
Range on Protein: 155-332
Range on HMM: 34-232/276.0
SWFAVMDGHGGVEAAKFAQA----QLHKVIAE---QPTFKDDPVKALHDGFLACDKMFLK----KSERDALTCGATAVTVLVRG--------RKLYVAWL
. |||.||| |  ||. |.     .| |..       | .||  .  .|      ..| .     .. .   . || . |   |        | | || .
alfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqrylqvanv

GDSQVAMCRNGEMVTLMNPHKPEREDEKQRIAdNEGVVVWYGAWRVNGVlSVSRAIGDRKLKQWV---IGKPDIA-EFDITDDCEYLIAGCDGLWDVMNT
|||   ..|  | . |   || .  .|||||  ..|. .  .  |.||.  ||||.||  .|.     |..| .. .. .|   ..||   ||||||.. 
GdssaflsrGneslelskdhkatdpeekqrik.ddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisG

E
.
k

PP2C_2 Protein phosphatase 2C 155-329 1.5e-07 23.9 Pfam-A 25-181 (212) alignment
Range on Protein: 155-329
Range on HMM: 25-181/212.0
SWFAVMDGHGGVE----AAKFAQ----AQLHKVIAEQPTF-KDDPVKALHDGFLACDKMFLK--KSERDALTCGATAVTVLVRGRKLYVAWLGDSQVA-M
...|| ||.|  .    .|..|      .| | ..|. .  ... ..... . ||  | . .  ... ..   ..| . .............||. .. .
wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvr

CRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWygawrvngvlsvsraigdrklkqwvigkpDIAEFDiTDDCEYLIAGCDGLWDVM
 |.||.  |  |.. | . | ... ...    .                             .| ... ... . |.   ||..| .
drdgevqllgepdsgeyanettfltsedaeeel.............................rirrlk.lepgdalllmTDGvsdsl

PP2C_2 Protein phosphatase 2C 155-329 1.5e-07 23.9 In-house 25-181 (212) alignment
Range on Protein: 155-329
Range on HMM: 25-181/212.0
SWFAVMDGHGGVE----AAKFAQ----AQLHKVIAEQPTF-KDDPVKALHDGFLACDKMFLK--KSERDALTCGATAVTVLVRGRKLYVAWLGDSQVA-M
...|| ||.|  .    .|..|      .| | ..|. .  ... ..... . ||  | . .  ... ..   ..| . .............||. .. .
wllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitpgeivffqiGDgaivvr

CRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWygawrvngvlsvsraigdrklkqwvigkpDIAEFDiTDDCEYLIAGCDGLWDVM
 |.||.  |  |.. | . | ... ...    .                             .| ... ... . |.   ||..| .
drdgevqllgepdsgeyanettfltsedaeeel.............................rirrlk.lepgdalllmTDGvsdsl

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 157-327 1.2e-20 67.3 In-house 24-213 (292) alignment
Range on Protein: 157-327
Range on HMM: 24-213/292.0
FAVMDGHG--GVEAAKFAQAQLHKVIAEQPTFKDDPVKALHDGFLACDKMfLKKSERDALTCGATA-VTVLVR-GRKLYVAWLGDSQVAMCR-----NGE
 ||.||||  | . |..|. .| . . |    . .  .||  . |      |.|.  ||   ..|| |   || .|.|..| .|||.. . |     . |
aavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllrildiaak.ldkltidaresattavvcarvrddralilanvGdsrallgrclggsdye

MVTLMNPHKPEREDEKQRIADNEGVVV--------WYGAWRV------NGVLSVSRAIGDRKLKQ-WVIGKPDIaefDITDDCEYLIAGcDGLWD
.. | . ||||  ||..||    | |         . |. ||      .| |..|||.||  |..  |. .|..   .|    .||  |  ||| 
liPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePel...qihagrqylgrg.pglwt

subfamily_PPM1H_pd Subfamily PPM1H 192-266 2.2e-10 32.9 In-house 138-210 (404) alignment
Range on Protein: 192-266
Range on HMM: 138-210/404.0
KALHDGFLACDKMFLKKSERDALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREdeKQRI
 || . || .|..  .  |.  .. | ||. .||   |||||  |||.  ..|..|.. | . . || |  .||.
GalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPete..RqRl

subfamily_PPM1G_pd Subfamily PPM1G 209-334 4.7e-28 91.4 In-house 289-421 (473) alignment
Range on Protein: 209-334
Range on HMM: 289-421/473.0
SERDALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWYGawRVNGVLSVSRAIGDRKLK---------QW
.|      |.||| .|....||.||  |||   ..|||. . |   |||| | |..||    | |   |  |||| | .|||.||   |         | 
keepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedg..RvnGGLnlsRAlGDhaYkkneeLplkeqm

VIGKPDIAEFDITDDCEYLIAGCDGLWDVMNTETV
.   |||    .|.. |.|.  |||.|.||. . |
isAlPDikvltlteedeFlvlAcDGiWnvmesqev

subfamily_TAB1_pd Subfamily TAB1 213-297 7.3e-08 24.6 In-house 126-213 (333) alignment
Range on Protein: 213-297
Range on HMM: 126-213/333.0
ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCR---NGEMVTLMNPHKPEREDEKQRIADNeGV-VVWYGAWRVNGVLSVSRAIGDRKLK
 .. |.||| .|.   |||||  |||.  ...   . ... |   |. . ||| .|..|  |. .      .. |     |.||| |.|
eisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdL.GldieqikrnkrlgskentRsiGdykvk

subfamily_PDP_pd Subfamily PDP 213-297 1.6e-07 23.7 In-house 149-241 (398) alignment
Range on Protein: 213-297
Range on HMM: 149-241/398.0
ALTCGATAVTVLVRGRKLYVAWLGDSQVAMCRNG-----EMVTLMNPHKPEREDEKQRIADN----EG-VVVWYGawRVNGVLSVSRAIGDRKLK
. . ||.|...|..|..|.||  ||..  ....      |.|.| . .  . |.| .||  .    |   |.  |  |. | |  .|| || ..|
valsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirng..RlLgeLqPlRAFGdvryK

subfamily_PP2D1_pd Subfamily PP2D1 229-334 3.1e-20 65.3 In-house 189-298 (492) alignment
Range on Protein: 229-334
Range on HMM: 189-298/492.0
KLYVAWLGDSQVAMCRNGEMVTLMNPHKPEREDEKQRIADNEGVVVWYGA-WRVNGVLSVSRA---IGDRKLKQWVIGKPDIAEFDITDDCEYLIAGCDG
 ||.|  |. |  .||.|....|   | |. . |..|.  . .|||  .   .|||.|.. |    .|| |||. || .| .    ... . .|.    |
vlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflvlAsnG

LWDVMNTETV
||.|.. | |
lWevlseeev