Gene PPM1G in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1G
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP134_AA protein Get Run
MbreP134_AA_20-488 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1G_pd Subfamily PPM1G 4-488 3.8e-186 612.7 In-house 1-472 (473) alignment 
Range on Protein: 4-488
Range on HMM: 1-472/473.0
FLEKPITDKEFEEGAdRFGHKFCVGSMQGWRADQEDAHLAIPDIDETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANGEVTQALQKAFL
.|.||...|| |... . ........|||||..||||| .|.|.||......|.|||||       ||.|.||..|.|.||||.|...|.|..||..|||
ylskpkvekesedes.neelsygasamqGwrvsqEDahncitdldedtslfavyDGHGG......kevakyvakklpdllkaqkgykegdvekaleeafl

ALDLQIKAEESLAELQQLAHAGNDSDDDdndSEDDEEDGDNIEALQADADIPIDELKRANgkradnagetatDGQLDQKRAKLQALLTGDLMEDDEDDDE
||| ..||||||.||...|.|..|.|..   .||||||.|.||.|...|.||.|||....            ||. ..|....||||.|...||.||.||
alDeklkaeeslkelkeiaeaeededee...eeddeededeiellteeaeipldellkrl............dgdgsekeelsqallegaasedeedede

DDEDDDDEDDNEEEAKDKDSKQKQSKDGKQSTKEGDDQDQAAD---------------------DSDEDEEGVEEQAFEHSESIRAQLLAALAQHGEGSE
|.|....|.|.|||.|....|.|..|.|||..||.|.......                     |.||.||..||.|.|..|...... .. ...|||.|
deeeeeeekdteeeskeeekkakaakegkqekkeedesekeeeeeekeeeeedekgeteeeeeededeeeeedeeeaeeeeeeedeedeeeeeedgegee

ALQAIQSMQEDEAPGYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSDGRIEGGLNLSRAL
| .......|.|.||..|||||.|.||.|. .|||||||.|         .||.|.|.|.|.|.||||||| |..|||.|||.||.|||..|||||||||
akeeldgseekeepGedsGttAvvaLlkekklivAnaGDsR.........cvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAl

GDWNYKQNAELDHRDQVrigsISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGV--VIKAAITELLDACMAPDTeTGDGSGCDNET
||..||.|.||....|.    |||||||.|..|...|||.|||||||||.|.||.|||..|....||   |......||||||.|||| .|||.||||.|
GDhaYkkneeLplkeqm....isAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdt.sgDGtGCDnmt

AMVVMLRD
...|.|..
viivllkk
subfamily_PPM1G2_pd Subfamily PPM1G2 5-117 5e-22 71.2 In-house 2-112 (287) alignment 
Range on Protein: 5-117
Range on HMM: 2-112/287.0
LEKPITDKEFEEGADRFgHKFCVGSMQGWRADQEDAHLAIPDI-----DETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANGEVTQALQ
|..|...|| . .|..   |.   .|||.| ..||||.  ...     |.. | ..|||||||       .|.|.....|   ..... |..|...|.|.
lsepvvakesascanal.tkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGG......akvakyagkklikkiakkksfkegaleqilk

KAFLALDLQIKAEESLAE
.|||..| ..  .|.|..
dafletDeellkdeklkd
subfamily_PPM1A_pd Subfamily PPM1A 18-115 2.4e-15 49.6 In-house 7-108 (282) alignment 
Range on Protein: 18-115
Range on HMM: 7-108/282.0
ADRFGHKFCVGSMQGWRADQEDAHLAIPDIDET--WACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGF--------ANGEVTQALQKAFLALDL
|.  | ...| ||||||.. |||| .. .. ..  |. . |||||.|       ||.|.|..|||. .  .| .         . || .||...||||| 
aegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaG......sevakyvkkhllenileeeelkeaaleasekdevkealrqgfLalde

QIKAEESL
.|..... 
airelstd
0034914 PP2C-like 21-488 4.7e-59 192.6 In-house 19-292 (295) alignment 
Range on Protein: 21-488
Range on HMM: 19-292/295.0
FGHKFCVGSMQGWRADQEDAHLAIPDI---DETWACYGVFDGHGGWcyaprpEVSKFVARHLLDCLKAQ-------EGFANGEVTQALQKAFLALDLQIK
. ....| |.||.|  .|||.|.....   .| ....||||||||.      .........|.. |. .         .    . .||.|||||.| .. 
lllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGh......aaaevasellvelllellekllllltlsledieealrkaflaadeell

AEESLAelqqlahagndsddddndseddeedgdniealqadadipidelkrangkradnagetatdgqldqkraklqalltgdlmeddedddeddedddd
..  |                                                                                               
elallr..............................................................................................

eddneeeakdkdskqkqskdgkqstkegddqdqaaddsdedeegveeqafehsesiraqllaalaqhgegsealqaiqsmqedeAPGYSSGTTANVMLLN
                                                                                       . ||||| |.|. 
....................................................................................pelagsGtTavvalir

ERLAIVANAGDCRFVLMppsrlavlcRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSdGRIEGGLNLSRALGDWNYKQNAELDHRDQVrigsISALPDI
.. ..|||.||.|.||.         |.|... ...|||| .| || ||..|||.|   ||. |.|...|||||...|..  | .....    .|| ||.
gnklyvanvGDSravll.........rngelvqltvdhkpvnelererilsaggavsh.grvngvlavtRalGdfdlklllsllllepl....vsaePdv

QVMELC-QDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDACMApdtetgdGSGCDNETAMVVMLRD
.|.||  .||.|..||.||.|. ......||..| ...||  ...| .||.|...|       . ..|| |..|| |..
tvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla.......rgsrDNiTvvvvrlng
PP2Cc_SM00332 24-484 4e-67 219.5 In-house 13-274 (274) alignment 
Range on Protein: 24-484
Range on HMM: 13-274/274.0
KFcvGSMQGWRADQEDAHLAIPDI--DETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANG----EVTQALQKAFLALDLQIKAEESLAE
..   ||||||  .||||  ..|    | |. .||||||||      .||.|||...| ..|| .  . ..    .|..||.||||..| .| .||.  |
gk..ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgG......sevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqske

LQQlahagndsddddndseddeedgdniealqadadipidelkrangkradnagetatdgqldqkraklqalltgdlmeddedddeddeddddeddneee
|..                                                                                                 
len.................................................................................................

akdkdskqkqskdgkqstkegddqdqaaddsdedeegveeqafehsesiraqllaalaqhgegsealqaiqsmqedeapgYSSGTTANVMLLNERLAIVA
                                                                                 .||.|| |.||..   .||
................................................................................alsGstavvallkkedlyva

NAGDCRFVLMPPSRlavlcrkgvAMDMSEDHKPEDEPERTRIERAGGTVDSDgRIEGGLNLSRALGDWNYKQNAeldhrdQVRIGSISALPDIQVMELCQ
|.||.| ||.  .          | ..|.||||||| || ||..|||.|  . |. |||..|||.||  .|.|       . .   |.|.||..| .|..
nvGDSravlcrngk.........avqlsvdhkpedederkRikkaggvvekg.rvngglavsrafGdhflkknk......klkepyitaepdvkvvtlts

DDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGvviK----AAITELLDACMAPDtetgdGSGCDNETAMVV
.|||..||.||.|.....|.|||..| . .||   |     .. ||||.. ...     | ..|| |..||
edeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqeaaelldeeairr.....ggseDniTvvvv
0049733 PP2C-like 24-112 2e-10 33.7 In-house 4-82 (235) alignment 
Range on Protein: 24-112
Range on HMM: 4-82/235.0
KFCVGSMQGW-RADQEDAHLAipdideTWACYGVFDGHGGWCyaprpeVSKFVARHLLDCLKAQ-EGFANGEVTQALQKAFLALDLQIKAE
.... |..|. |  .|||.|.       .....|.|||||.       ........|...|... ...   ....||.|||||.. .. ..
svgaasdigrvrkvneDavlv......glllfavaDGhggha......agevasellvetllelllelllldleealrkaflaaneallel
subfamily_PPM1E_pd Subfamily PPM1E 26-110 5.1e-08 25.4 In-house 7-92 (265) alignment 
Range on Protein: 26-110
Range on HMM: 7-92/265.0
CVGSMQGWRADQEDAHLAIPDIDE--------TWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANGEVtQALQKAFLALDLQIK
 . .... |  .|| |.|..|..|        . | ..|||||||       | .|. |.||   |  || . .  . .||..|| ..| .. 
siaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgG......veaakyaaahlhellvrqeklkedpa.ealkeafkltDerfl
PPM_PTC7 27-113 4.4e-11 35.7 In-house 5-91 (259) alignment 
Range on Protein: 27-113
Range on HMM: 5-91/259.0
VGSMQGWRADQEDAHLAIP-----DIDETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANG-EVTQALQKAFLALDLQIKAEE
. ..||.|   ||||.| .     . .. .| ..|||||||       |..|... || ..|| .. | .. .. .|| |.|||||. .. . 
asafqgfrksmedahialanlesssgkdsvaffavfdghgg......reaakyarehleeilkerksfeeleklekalrksflaldtdeelks
PP2C Protein phosphatase 2C 27-111 1.7e-10 33.9 Pfam-A 5-90 (255) alignment 
Range on Protein: 27-111
Range on HMM: 5-90/255.0
VGSMQGWRADQEDAHLAIPD-----IDETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANG-EVTQALQKAFLA-LDLQIKA
. ..||.|   ||||.|...      ....| ..|||||||       |..|. . || ..|| |. |  . .| .||.|.||| .| ..| 
aselqgarksmedahialknlekssgkssvaffavfdghgg......reaakyarehleeilkeqksflelekvekalrksfladtdeelks
PP2C Protein phosphatase 2C 27-111 1.7e-10 33.9 In-house 5-90 (255) alignment 
Range on Protein: 27-111
Range on HMM: 5-90/255.0
VGSMQGWRADQEDAHLAIPD-----IDETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANG-EVTQALQKAFLA-LDLQIKA
. ..||.|   ||||.|...      ....| ..|||||||       |..|. . || ..|| |. |  . .| .||.|.||| .| ..| 
aselqgarksmedahialknlekssgkssvaffavfdghgg......reaakyarehleeilkeqksflelekvekalrksfladtdeelks
PPM_PTC7_SpoIIE 27-111 1.5e-08 27.7 In-house 5-86 (230) alignment 
Range on Protein: 27-111
Range on HMM: 5-86/230.0
VGSMQGWRADQEDAHLAIP-----DIDETWACYGVFDGHGGWCyaprpevsKFVARHLLDCLKAQEgFANGE-VTQALQKAFLALDLQIKA
. ..||.|   |||| . .     . . ... .|..|||||          ......| ..|...  ||..| . ..|....|||. ... 
asaaqgarksmedahispansekssggrlalvvgdvdGhGgra........alamgllrtalrela.faglekpeeilrrlnlalaadled
subfamily_PPM1D_pd Subfamily PPM1D 48-112 5.6e-10 31.8 In-house 32-93 (309) alignment 
Range on Protein: 48-112
Range on HMM: 32-93/309.0
DETWACYGVFDGHGGwcyaprPEVSKFVARHLLDCLKAQEGFANG---EVTQALQKAFLALDLQIKAE
.  .|. .|||||||       | .||. .||.  .| |..| .    .|..|...||||.  ..| .
elevafvavfDGHGG......keAakfarehlwsvikkqkkflssepedvleAireaflatheamkkk
subfamily_PDP_pd Subfamily PDP 225-443 1.2e-20 66.9 In-house 75-309 (398) alignment 
Range on Protein: 225-443
Range on HMM: 75-309/398.0
QK--QSKDGKQSTKEGDDQDQAADDSDedeEGVEEQAFEHSESIRAQLLAALAQHGEG--SEALQAIQSMQEDE-APGYSSGTTANVMLLNERLAIVANA
.|  .... |....  . ... ...     . ..|..  . |... .|  |  .  .   .|||.. .. . .| .    ||..| . |....   |||.
lkllkkskhkldvvsdeakklslsels...kylqelleaevekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAnt

GDCRFVLmppsrlAVLCRKG--VAMDMSEDHKPEDEPERTRIERAGGTVD-----SDGRIEGGLNLSRALGDWNYKQNAELDHRDQVR-----IG-----
|||| ||      .|   .|   |. .|.|.  . | | .||...    .      .||. | |  .|| || .|| ..||...   .     .      
GDcravl......gvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyk

---SISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLR
    ..| |...  .| ..| |.||| ||.|.......||..  
tPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVg
subfamily_PPM1H_pd Subfamily PPM1H 244-357 3.1e-07 22.5 In-house 109-210 (404) alignment 
Range on Protein: 244-357
Range on HMM: 109-210/404.0
AADDSDEDEEGVEEQAFeHSESIRAQLLAALAQhgegSEALQAIQSM--QEDEAPGYSSGTTANVMLLNERLAIVANAGDCRFVLMPPSRLavlcrkgva
 ...|....    .. . . ..|... |   |      .| . . ..  .| ||   . | || | |. .    ||||||.| .|.  ...         
nteesskespssvseiy.eekeiskeeLviGal....esaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdei.........

MDMSEDHKPEDEPERT
...|.|. || | .| 
iplsadftPeteRqRl
subfamily_PPM1A_pd Subfamily PPM1A 258-486 1.7e-45 148.5 In-house 83-280 (282) alignment 
Range on Protein: 258-486
Range on HMM: 83-280/282.0
QAFEHSESIRAQLLAALAQHGEGSEALQ----AiqsmqedeapgyssGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDE
.. |..| .| ..||.  .  | |. |.    .              |.|| ..|..|.  |.||.||.|         |||||.| |. ..|||||...
ekdevkealrqgfLaldeairelstdlktadks..............GsTavtvlvsekhliianlGDsR.........avlcrngkaaflteDHkpsrp

PERTRIERAGGTVDsDGRIEGGLNLSRALGDWNYKQNAELDHRDQVrigsISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIK
 |..||| |||.|   .|..| | .||||||..||.. |..  .|     .|| |.....|  ..|.|.||||||||  .....||.. | |....  ..
kEkkRieqAGGsvv.vsRvnGaLAvsRalGDyeykeeeekkaeeql....vsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadele

AAITELLDACMAPDTEtgdgsgcDNETAMVVML
.  ..|.| ..  ...       || ...||..
evakalvdkalekgsr.......DNlsvlvvlf
subfamily_TAB1_pd Subfamily TAB1 262-434 4.1e-10 32.0 In-house 92-261 (333) alignment 
Range on Protein: 262-434
Range on HMM: 92-261/333.0
HSESIRAQLLAALAQHGEGSE---ALQAIQSMQEDeapgYSSGTTANVMLLNERLAIVANAGDCRFVLMPPSRlavlcrKGVAMDMSEDHKPEDEPERTR
  .... ||   ....   ..    ....|...|.     | |||| | |.      |||.|| | .|.   .      .     .| ||. . | | .|
ekddlqsqlPegvssyeleeqypekierlqeleee....isgGttAvvalifnnkLyVaNvGdsrAllvkrke......sekvkqLsvdHttdNedEllR

IERAG---GTVDSDGRIeGGLNLSRALGDWNYKQN-AELDHRDQVRIGSISALPDIQVM-ELCQDDEFIVLACDGIWNSMT
... |    .. . .|. |. .  |..||.. |.   . |   . .   . | ||||   .. .   |.||  ||. ... 
lkdLGldieqikrnkrl.gskentRsiGdykvkkgykdvdilssakgePviaePdiqgaypiddityflvlmSdGvyktLe
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 283-441 4.6e-25 81.3 In-house 80-219 (255) alignment 
Range on Protein: 283-441
Range on HMM: 80-219/255.0
ALQAIQsMQEDEAPgYSSGTTANVMLLNERLAIVANAGDCRFVLMppsrlavlCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSD---GRIEGGLNLS
| ..|. .| .| |    |||| ..|. |   ..|| || | ||          ..|.|  .| |||| .| |. ||...|||| |.    |..| | .|
aykeis.tqiserp.kfiGttaasvliiedkvyianvGdsrvvlc........qkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavs

RALGDWNYKQNaeldhrdqvrigsISALPDIQ-VMELCQDDEFIVLACDGIWNSMTSQQVVDY
|||||   .               . . ||..  .|  ..|.|..|||||||. .. .. |. 
ralGdsflePf.............vvpdPdlsqsleiskkdkflilacdGiwdlisdeeavei
PPM_PTC7_SpoIIE 283-458 1.8e-17 56.9 In-house 72-216 (230) alignment 
Range on Protein: 283-458
Range on HMM: 72-216/230.0
ALQAIQSMQEDEAPG--YSSGTTANVMLLNERL--AIVANAGDCRFVLMPPSRLavlcrkgvamdmsedhkpedepERTRIeRAGGTVD---SDGRIEGG
.|...    ... .    |||.|| | |..       ||||||....|. ...                       ||.||  ||| ..    .||. | 
ilrrlnlalaadledepsssgaTavvalidpstgklyvanaGdsppllvrddgg......................ereri.vagglpslGilpgrvfgv

LNLSRALGDWNYKQnaeldhrdqvRIGSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGvvikaAITE
|..|.| ||  ..             | ..| || .  || ..|||..||.||.|. ...|..|| .| .. |      |  .
lavslapGdlllly..........tDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeg
0049733 PP2C-like 285-487 3e-32 104.9 In-house 77-234 (235) alignment 
Range on Protein: 285-487
Range on HMM: 77-234/235.0
QAIQSMQEDEAPGYSSGTTANVMLLNERLAIVANAGDCRFVLMppsrlavlcRKGVAMDMSEDHKPEDEPERTRIERAGGTVdsdgRIEGGLNLSRALGD
.|. ...... . . .|||| |.|| .. ..|||.||.|..|.         |.| .. ..|||.| .| || ||..||| |    |. |.| |.|||||
eallelalaspelagmgtTavvalldggklyvanvGDsrayll.........rdgklvqltedhspvnelerqriitaggav....rvpgrlaltralGd

WNYKqnaeldhrdqvrigsisalPDIQVMELCQDDeFIVLACDGIWNSMTSQQVVDYLRVrftkgVVIKAAITELLDACMApdtetgdGSGCDNETAMVV
. .|                   ||..|.|| ..| |..||.||.|. ......||.||        ...|  .|.....|       . |.|| |..||
lllk...................pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala.......rggrDNiTvvvv

MLR
.|.
rld
subfamily_PPM1K_pd Subfamily PPM1K 285-445 1.3e-21 69.9 In-house 83-228 (263) alignment 
Range on Protein: 285-445
Range on HMM: 83-228/263.0
QAIQSMQEDEAPGYSSGTTANVMLLNERLA-IVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSD----GRIEGGLNLS
.    ..  ||   |||||| | || .    ..|. || |         |.|||.| |. ...||.|| | |. || .|||.|...     ...| | ..
krylefsvaeaellssGttatvsllrdGtelvlaslGdsr.........ailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamt

RALGDWNYKQNaeldhrdqvriGSIsALPDIQVMEL-CQDDEFIVLACDGIWNSMTSQQVVDYLRVR
|.||| . |.            | | | |. . ...  ..| |.||  ||| . ..||.. |..|. 
rslGdldlkry...........Gvi.atPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlc
PP2C Protein phosphatase 2C 288-469 3.8e-45 147.4 Pfam-A 89-252 (255) alignment 
Range on Protein: 288-469
Range on HMM: 89-252/255.0
QSMQEDEaPGYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAM-DMSEDHKPEDEPERTRIERAGGTVDSDGRIEGGLNLSRALGDWN
.|... .    .||.|| |.|...   .|||.||.|         ||||||. |   ..|||||.|| || |||.|||.|.  ||. | |..||||||. 
ksskant.epsksGstavvalirgkklyvAnvGDSr.........avLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfe

YKQNAeldhrdqvrIGSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDACMAPDTE
.|..             .|| ||... .| ..|||..||.||.|. ...|..||  | . .|.   . |..||.| ..|. .|
lkpke.........eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse
PP2C Protein phosphatase 2C 288-469 3.8e-45 147.4 In-house 89-252 (255) alignment 
Range on Protein: 288-469
Range on HMM: 89-252/255.0
QSMQEDEaPGYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAM-DMSEDHKPEDEPERTRIERAGGTVDSDGRIEGGLNLSRALGDWN
.|... .    .||.|| |.|...   .|||.||.|         ||||||. |   ..|||||.|| || |||.|||.|.  ||. | |..||||||. 
ksskant.epsksGstavvalirgkklyvAnvGDSr.........avLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfe

YKQNAeldhrdqvrIGSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDACMAPDTE
.|..             .|| ||... .| ..|||..||.||.|. ...|..||  | . .|.   . |..||.| ..|. .|
lkpke.........eqlvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse
subfamily_PPM1G2_pd Subfamily PPM1G2 291-486 7.5e-50 162.5 In-house 105-286 (287) alignment 
Range on Protein: 291-486
Range on HMM: 105-286/287.0
QED-EAPGYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSDgRIEGGLNLSRALGDWNYKQ
..| .    |.|.|| |.|..|.  .|||||| |         |||. || .  .| ||||..| |..||. |||.|. . |. | | |||||||...|.
lkdeklkdesaGstavvvlikeeklyvanaGDsr.........avlsskgnvkalsfDhkPqeesekkriiaagGfveln.rvngnLalsralgDfefkk

NAELDHRDQVrigsISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDACMAPDTETGdGSGCDNETAMVVML
| ..  ..|.    . |.||. | .| .||||.||||||||. .|...|||..| |...|  ... |.|||| |.|||.... | |||| |...|.|
nvkkkpeeqi....vtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssnt.gvGcDnmtvvivvl
subfamily_ILKAP_pd Subfamily ILKAP 291-443 7.4e-28 90.5 In-house 104-240 (293) alignment 
Range on Protein: 291-443
Range on HMM: 104-240/293.0
QEDEAPGYSSGTTANVMLLNERLAIVANAGDCRFVLMppsRLAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVdSDGRIEGGLNLSRALGDWNYKQn
 . . | .  |.|| |.|  . .  ||| || . ||.   |     .| ... .. ||.| .. || ||..|||.|  |||. | |. ||..|| ..|. 
askakPvWkdGstatvvlvldnvlyvanlGdskavlv...rkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvv.rdgrvlGvlevsrsiGdgrfkr.

aeldhrdqvrIGsISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLR
          .| ... ||.. .|| ..| |.||||||.|.... ..||..  
..........lG.vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfil
subfamily_PPM1E_pd Subfamily PPM1E 294-486 2.5e-26 85.5 In-house 96-262 (265) alignment 
Range on Protein: 294-486
Range on HMM: 96-262/265.0
EAPGYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSDG--RIEGGLNLSRALGDWNYKQna
|  .. ||.|| |.|....   ||  || .         |.|.||| |. . . ||||.| |. ||| |||.|   |  |. | |..|||.|| ..|.  
ereklksGstavvvliekdqlyvaWlGDsq.........allvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkp..

eldhrdqvrigSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDAcMAPDtetgDGSgCDNETAMVVML
            .|. .|.  .|| ...|...|||||.|. .. ..||. ..  ...|.  .. ...|| . .| .    .||  || |..||.|
...........yvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllve.aake....ags.sDnitvvvvfl
PPM_PTC7 297-469 2e-43 141.7 In-house 98-256 (259) alignment 
Range on Protein: 297-469
Range on HMM: 98-256/259.0
GYSSGTTANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAM-DMSEDHKPEDEPERTRIERAGGTVD--SDGRIEGGLNLSRALGDWNYKQNAEl
  .||.|| | |...   .|||.||.|         |||||.| |   ..|||||..| || |||.|||.|.  ..||. | |..|||.||. .|..   
pstsGstAvvalitgsklyvAnvGDSr.........avLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket.

dhrdqvRIGSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGvVIKAAITELLDACMAPDTE
      .   .|| |||.. ..  .|||..||.||.|. ...|..||  | .. |.     |...|.| ..|...|
......eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargse
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 297-387 1.9e-10 33.8 In-house 82-185 (292) alignment 
Range on Protein: 297-387
Range on HMM: 82-185/292.0
GYSSGTTANVM-LLNERLAIVANAGDCRFVLMppsRLAVlCRKGVAMDMSEDHKPEDEPERTRIERAGGTVD----------SDGRI------EGGLNLS
. |..|..      ..|  |.|| || | .|    |      .   . .| ||||||  || || |||| |.             |.      ||.| ||
resattavvcarvrddralilanvGdsrallg...rclg.gsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlals

RALGDWNY
|||||   
ralGdfhl
subfamily_PPM1L_pd Subfamily PPM1L 299-446 5.6e-22 71.3 In-house 105-236 (269) alignment 
Range on Protein: 299-446
Range on HMM: 105-236/269.0
SSGTTANVMLLNERLAIVANAGDCRFVLMPpsrlavlcRKGVAMDMSEDHKPEDEPERTRIERAGGTVDSDG--RIEGGLNLSRALGDWNYKQNaeldhr
 .|||| . |..|.  |||| || | ||.         ..| |. .| ||||..  || ||..||| .  .|  |..| |  ||||||.  |..      
iaGttalialvqesdlivanvGdsrGvlyd........krGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdk......

dQVrigsISALPDIQVMELCQ-DDEFIVLACDGIWNSMTSQQVVDYLRVRF
 ..    . | |||  ..| . . ||..||.||.|.... .. | ... |.
.nl....viadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerl
subfamily_PPM1D_pd Subfamily PPM1D 299-368 6.3e-10 31.6 In-house 107-173 (309) alignment 
Range on Protein: 299-368
Range on HMM: 107-173/309.0
SSGTTANVMLLNERLAIVANAGDCRFVLMPPSRlavLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDS
 .|||| |... ..   ||. || . ||          .| .|  . .|||||.  |..|||..|| |  
taGttasvviirreklyvahvGDsaivlgvkep...kekklrakeltkdHkPespeekerieelGGevaa
subfamily_PP2D1_pd Subfamily PP2D1 304-446 2.5e-16 52.5 In-house 180-306 (492) alignment 
Range on Protein: 304-446
Range on HMM: 180-306/492.0
ANVMLLNERLAIVANAGDCRfvlmppsrlAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTVDS---DGRIEGGLNLSRALGdwNYkQNAELDHrdqvr
 .| | .  .  .||||. .         |||||.|.|. .  .| |... ||||.|.||..| .    |...| |.  | ||  ||  . .| .     
sevhleelgvlyianaGnvq.........AvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLG..ny.GdpkLkk.....

igSISALPDIQVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRF
  |.   | .. ..| . . |.|||  |.|. .. ..|.  ..  .
..svipePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtl
subfamily_KAPP-like_pd Subfamily KAPP-like 313-462 8e-13 41.0 In-house 106-248 (266) alignment 
Range on Protein: 313-462
Range on HMM: 106-248/266.0
LAIVANAGDCRFVLM--PPSRLAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTV-DSDGRIEgGLNLSRALGDWNYKQNAeldhrdqvrIGSISAlPD
||.| ..|. |..         | |.|   .. .| ||| .|. |. ||   | |. |.. ||. || .||||||   |.           || ||  | 
lalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrin.GlavsralGdhfikeln.........iGlise.py

I-QVMELCQDDEFIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAAITELLDA
. . . |   |.|...| ||.|. .. .. .. ... . ..   .   . ||..
vsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmassllet
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 332-462 9.7e-12 37.3 In-house 137-258 (276) alignment 
Range on Protein: 332-462
Range on HMM: 137-258/276.0
LAVLCRKGVAMDMSEDHKPEDEPERTRIERAGGTV-DSDGRIEgGLNLSRALGDWNYKQNAeldhrdqvrIGSISAlPDI-QVMELCQDDEFIVLACDGI
 | |.|   .. .| ||| .|  |. ||   | |. |.. ||. || .||||||   |.           || ||  | . . . |   |.|...| ||.
saflsrGneslelskdhkatdpeekqrikddGitlsdnqtrin.GlavsralGdhfikeln.........iGlise.pyvsnrilltpfdkflivasdGl

WNSMTSQQVVDYLRVRFTKGVVIKAAITELLDA
|. .. .. .. ... . ..   .   . ||..
wdvisGkdaiekvkslydqqatedkmassllet
subfamily_PHLPP_pd Subfamily PHLPP 333-444 4e-09 28.7 In-house 117-214 (246) alignment 
Range on Protein: 333-444
Range on HMM: 117-214/246.0
AVLCRKGVAMDMSEDHKPEDEpERTRIERAGGTVDSDGRIEGGLNLSRALGDWNYkqnaeldhrdqvrIGSISALPDIQVMELCQDDEFIVLACDGIWNS
|||.|.|  . .|. .. |.. |  ||  | . .. |..|.| .. .| ||                   ..   | .. . | ..||....  . .|..
avliRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytfl.............fPvvlPkphvrevlLteqdellivGnkalWev

MTSQQVVDYLRV
.  ...|. .| 
lsideaveavrk
subfamily_PPM1D_pd Subfamily PPM1D 376-486 5.6e-09 28.5 In-house 201-307 (309) alignment 
Range on Protein: 376-486
Range on HMM: 201-307/309.0
LNLSRALGD-WNYKQNAEldhrDQVrigsISALPDIQVMELCQDDE-FIVLACDGIWNSMTSQQVVDYLRVRFTKGVVIKAA----ITELLDACMapDTE
|...|.||| | |... .      |    .|  ||..|..| ...| ||.|| ||.|| .|....|. ..   .|... .       . |..  .  .. 
LavaRslGDlWsynaksg....efv....vsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkeal..qrw

TGDGSGCDNETAMVVML
      .|| ...||.|
rskklraDnvsvivvil
PPM_PTC7_motif 423-469 1.4e-08 28.1 In-house 1-48 (51) alignment 
Range on Protein: 423-469
Range on HMM: 1-48/51.0
VLACDGIWNSMTSQQVVDYLRVRFTK-GVVIKAAITELLDACMAPDTE
.||.||.|. ...|..|| .| . .| |     |...| | ..|. .|
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargse