Gene MbrePPM-Un-3 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP135_AA protein Get Run
MbreP135_AA_22-304 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 23-304 7.6e-69 224.7 In-house 15-292 (295) alignment 
Range on Protein: 23-304
Range on HMM: 15-292/295.0
GLHGPHIALGACGIQGYRRNMEDAHILNNDLLEDGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQVSDRSALTDDALEQLMIDACKSTDHDLPSH
 .. ...  |.. .||.|...|||..   .|| . ..|.|..  ||||| |||  |.. |.. .. .|...   . |... .|. ...| ...|..| ..
sslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellel

IPNfrtVEDMEDPGSTCVGALLLEDRLVVFNIGDSRAVLAqaiDSPDALLATRDHKPQTPSERQRIEAAGGFVAGNRVCQSLAVSRAFGDFSFK-DPNIK
. .     ..   |.|.| ||. ...|.|.|.|||||||     .  ..  |.||||  ..||.||..|||.|  .||. .|||.||.|||..|  ..  
all...rpelagsGtTavvalirgnklyvanvGDSravll...rngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllsll

PEEHMVTCIPDITIVPRN-ENLEFIILACDGVWDVLRSETVVGMVREELLSEAALDAVCQTVVMDALQRGSSDNISCCILTLDG
..|..|...||.|..... |. .|..||.||.|||| .|..| .||. | .   |..... .|  ||.|||.|||..... |.|
lleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
subfamily_PPM1G2_pd Subfamily PPM1G2 28-303 8.2e-102 333.0 In-house 18-287 (287) alignment 
Range on Protein: 28-303
Range on HMM: 18-287/287.0
HIALGACGIQGYRRNMEDAHILNNDLLE--DGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAalrqvsdRSALTDDALEQLMIDACKSTDHDLPSHipn
 ...|....||||.||||||||.|.|||  | . |.|.|..|||||...| .|...| .|.|.       .......||||...||...||..| ..   
ltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiak.......kksfkegaleqilkdafletDeellkd...

fRTVEDmEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDsPDALlaTRDHKPQTPSERQRIEAAGGFVAGNRVCQSLAVSRAFGDFSFKDPN-IKPEE
 ....| |..|||.| .|. |..|.|.|.|||||||.....  .||  ..|||||. ||..||.||||||. |||...||.|||.|||.||. . .||||
.eklkd.esaGstavvvlikeeklyvanaGDsravlsskgn.vkal..sfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpee

HMVTCIPDITIVPRNENLEFIILACDGVWDVLRSETVVGMVREELLSEAALDAVCQTVVMDALQRGSS------DNISCCILTLD
..||..||...  ..|. ||..|||||.||||....|| .|||.| |.|.||..........|.. ||      ||....|..|.
qivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvll
subfamily_PPM1G_pd Subfamily PPM1G 29-87 1e-07 24.4 In-house 19-74 (473) alignment 
Range on Protein: 29-87
Range on HMM: 19-74/473.0
IALGACGIQGYRRNMEDAHILNNDLLEDGSglvLIACLDGHGGRAAALSAAHDLPQKVA
.. ||   ||.| ..||||    || || |   | |  |||||.. |   |. ||. . 
lsygasamqGwrvsqEDahncitdldedts...lfavyDGHGGkevakyvakklpdllk
subfamily_PPM1A_pd Subfamily PPM1A 30-302 1.1e-69 227.9 In-house 13-280 (282) alignment 
Range on Protein: 30-302
Range on HMM: 13-280/282.0
ALGACGIQGYRRNMEDAHILNNDLLeDGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAA--LRQvSDRSALTDDALEQLMIDACKSTDHDLPSHIPNFR
  |    ||.|..|||||.   .|    ..  . | .|||.|. .|  ... |....     |.. .  .| ..|.... . ..  ..|... ..  . .
rygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelke.aaleasekdevkealrqgfLaldeairelstdlk

TVedmEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIdspDALLATRDHKPQTPSERQRIEAAGGFVAGNRVCQSLAVSRAFGDFSFKD-PNIKPEEHM
|    .  |||.|..|. |. |.. |.|||||||..      |  .|.||||..|.|..|||.|||.|  .||. .||||||.||...|. .. |.|| .
ta...dksGsTavtvlvsekhliianlGDsRavlcrng...kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeql

VTCIPDITIVPRNENLEFIILACDGVWDVLRSETVVGMVREELLSEAALDAVCQTVVMDALQRGSSDNISCCILTL
|.  |..|.. |.|. .|..|||||.|||| .|.|| .||..|     | .|....|  ||..|| ||.|......
vsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
0049733 PP2C-like 30-303 3.9e-49 160.0 In-house 4-234 (235) alignment 
Range on Protein: 30-303
Range on HMM: 4-234/235.0
ALGACGIQGY-RRNMEDAHILnndlledgsGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQvsdrsaLTDDALEQLMIDACKSTDHDLPSHIPNFRt
  ||. ..|. |...|||...         ||.|.|  ||||| ||.  |.. |.. ....|..      |.   ||.....|.. ... | ..  . . 
svgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalasp.

veDMEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQaidSPDALLATRDHKPQTPSERQRIEAAGGFVagnRVCQSLAVSRAFGDFSFKdpnikpeehmvt
  ..   |.|.| ||| ...|.|.|.|||||.| .   .  ..  |.||.|  . |||||..|||.|   || ..||..||.||. .|            
..elagmgtTavvalldggklyvanvGDsrayllr...dgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk............

ciPDITIVPRNENLeFIILACDGVWDVLRSETVVGMVREellseAALDAVCQTVVMDALQRGSSDNISCCILTLD
  ||.|... ...  |..||.||.|||| .|..|...|.       |.......|  ||.||. |||.. .. ||
..pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrld
PP2C Protein phosphatase 2C 31-295 1.6e-61 201.1 Pfam-A 3-255 (255) alignment 
Range on Protein: 31-295
Range on HMM: 3-255/255.0
LGACGIQGYRRNMEDAHILNNDLL--EDGSGLVLIACLDGHGGRAAALSAAHDLPqKVAAALRQVSDRSaltddALEQLMIDACKS-TDHDLPSHIPNfr
.||. .||.|..||||||....|   .. |   ..|  |||||| ||  |. .|. ....  .. ..        .|......  . ||  | |.. |  
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle.eilkeqksflele.....kvekalrksfladtdeelksskan..

tVeDMEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDSPdaLLATRDHKPQTPSERQRIEAAGGFVA-GNRVCQSLAVSRAFGDFSFKDPNikpeEHM
     .. |||.| ||. ...| | |.|||||||... ..      |.||||. ..||.|||.|||.|   .||..|||||||.||| .|. .    | .
.t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke....eql

VTCIPDITIVPRNENLEFIILACDGVWDVLRSETVVGMVREELLSEAALDAVCQTVVMDALQRGSSDNI
|.. ||.| |...|. ||.|||.||.|||| ....| .||.|| .. ... ... .| .|..|||.|||
vsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 31-295 1.6e-61 201.1 In-house 3-255 (255) alignment 
Range on Protein: 31-295
Range on HMM: 3-255/255.0
LGACGIQGYRRNMEDAHILNNDLL--EDGSGLVLIACLDGHGGRAAALSAAHDLPqKVAAALRQVSDRSaltddALEQLMIDACKS-TDHDLPSHIPNfr
.||. .||.|..||||||....|   .. |   ..|  |||||| ||  |. .|. ....  .. ..        .|......  . ||  | |.. |  
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehle.eilkeqksflele.....kvekalrksfladtdeelksskan..

tVeDMEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDSPdaLLATRDHKPQTPSERQRIEAAGGFVA-GNRVCQSLAVSRAFGDFSFKDPNikpeEHM
     .. |||.| ||. ...| | |.|||||||... ..      |.||||. ..||.|||.|||.|   .||..|||||||.||| .|. .    | .
.t.epsksGstavvalirgkklyvAnvGDSravLcrkdnak..keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke....eql

VTCIPDITIVPRNENLEFIILACDGVWDVLRSETVVGMVREELLSEAALDAVCQTVVMDALQRGSSDNI
|.. ||.| |...|. ||.|||.||.|||| ....| .||.|| .. ... ... .| .|..|||.|||
vsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7 31-295 4.3e-59 193.0 In-house 3-259 (259) alignment 
Range on Protein: 31-295
Range on HMM: 3-259/259.0
LGACGIQGYRRNMEDAHILNNDLL--EDGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQVSDRsaltddALEQLMIDACKS--TDHDLPSHIPNf
.||. .||.|..||||||....|   .. .   . |  |||||| ||  |. .|..... . .  ...       ||. ....  .  ||  | |.. | 
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele......klekalrksflaldtdeelkssean.

rtVeDMEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDSPdaLLATRDHKPQTPSERQRIEAAGGFVA---GNRVCQSLAVSRAFGDFSFKDPNIkpE
      .. |||.| ||. ...| | |.|||||||..  ..      |.||||. ..||.|||.|||.|     .||. .|||||||||| .|.  .  |
..t.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav..kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket..e

EHMVTCIPDITIVPRNENLEFIILACDGVWDVLRSETVVGMVREELLSEaALDAVCQTVVMDALQRGSSDNI
| .|.. |||. ....|. ||.|||.||.|||. ....| .||.|| .. ... ... .| .|..|||.|||
eqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 31-302 7.1e-40 129.9 In-house 8-253 (255) alignment 
Range on Protein: 31-302
Range on HMM: 8-253/255.0
LGACGIQGYRRNMEDAHILNNDlLEDGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRqVSDRsaltddALEQLMIDACKSTDHDLpshipnfrtVE
.| . . | |  |||  ..     .|.|.  ..| .|||||||||  |...|.. .|  |  . .       . .. . .| |...  .          |
vgfsdmiGrrptmedelviyGs.frdksdedyyalfdGhgGraaakfaseelykilaelld.lnna......nPvkslkkaykeistqi.........se

DMEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDSpdALLATRDHKPQTPSERQRIEAAGGFVAGN----RVCQSLAVSRAFGDfSFKDPNIKPEEHM
     |.| . .|..||. .. |.||||.||.|      |   . ||||. .||..||...||.|  .    ||   ||||||.|| || .| . |. ..
rpkfiGttaasvliiedkvyianvGdsrvvlcqkdgt..akrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGd.sflePfvvpdPdl

VTcipDITIvprNENLEFIILACDGVWDVLRSETVVGMVreelLSEAALDAVCQTVVMDALQRGSSDNISCCILTL
      ..|    .. .|.||||||.||..  |  | .|    .. .  .  ....   | ..||.|||| ... |
sq...slei...skkdkflilacdGiwdlisdeeaveiv....agisdpekaaeklrdlayssGstdnisvivikl
PPM_PTC7_SpoIIE 31-290 4.6e-33 107.9 In-house 3-225 (230) alignment 
Range on Protein: 31-290
Range on HMM: 3-225/230.0
LGACGIQGYRRNMEDAHILNNDLL--EDGSGLVLIACLDGHGGRAaalsaahdlpQKVAAALRQVSDRSA-----LTDDALEQLMIDACKSTDHDlpshi
.||...||.|..||||||.....    .|.  ....  |||||||          ..... ||.. .. |     . ...|. |   ... ....     
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..........alamgllrtalrelafaglekpeeilrrlnlalaadlede.....

pnfrtvedMEDPGSTCVGALLLEDR--LVVFNIGDSRAVLAQAiDSPdallatrdhkpqtpsERQRIeAAGGFVA----GNRVCQSLAVSRAFGDFSFKD
         .. |.|.| ||.  ..  | | | |||...| .. |                 || || .|||..     ..|| ..||||.|.||. ...
........psssgaTavvalidpstgklyvanaGdsppllvrd.dgg...............ereri.vagglpslGilpgrvfgvlavslapGdlllly

pnikpEEHMVTCIPDiTIVPRNEN-LEFIILACDGVWDVLRSETVVGMVREELLSEaaldaVCQTVVMDALQRG
     .. .|.. || |.  . ..  ||.|||.||.||||... .| .||.||..      ...  . |..  .
.....tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDitll
PP2Cc_SM00332 32-299 6.5e-66 215.5 In-house 13-273 (274) alignment 
Range on Protein: 32-299
Range on HMM: 13-273/274.0
GACGIQGYRRNMEDAHILNNDLLeDGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQVSDRSaltDDALEQLMIDACKSTDHDLPSHI----PNFr
| .  ||.|..|||||.  .||    ..  ...  ||||| ..|  ..  ||. ..  | ...| .   .|. |... .| .||| ..  .     ... 
gkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...eddveealkkaflstdeeileeeqskelen.

tvedmEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDspdALLATRDHKPQTPSERQRIEAAGGFVAGNRVCQSLAVSRAFGDFSFKDPNiKPEEHMV
     .. |||.| ||| ...|.|.|.|||||||... .   |.  ..||||. ..||.||..|||.|. .|| ..|||||||||. .|... |..| ..
.....alsGstavvallkkedlyvanvGDSravlcrngk...avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk.klkepyi

TCIPDITIVPRNENLEFIILACDGVWDVLRSETVVGMVREELLSE--AALDAVCQTVVMDALQR-GSSDNISCCI
|. ||...|  ... ||.|||.||.|||| ...||..||. | ..   . ..... ... |..| ||.|||....
taepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvv
subfamily_PPM1K_pd Subfamily PPM1K 32-302 1.5e-27 89.3 In-house 7-258 (263) alignment 
Range on Protein: 32-302
Range on HMM: 7-258/263.0
GACGIQGYRRNMEDAHILnndlLEDGSGLVLIACLDGHGGRAAALSAAHDLPQKvaaaLRQVSDRsaltDDALEQLMIDACKSTDHDLPSHIPNFRTVED
|   ..| |.. ||   |    .|    |. .|  |||.| |||  . ..| .     |... ..    .. ||... .| .  |..| ...    . ..
GkdsliGkraenedrikl....keldpellyvavfdGhaGsaaadfvhdkleki....lkrllek....ekdleivlknafeeldkklkrylefsvaeae

MEDPGSTCVGALLLED-RLVVFNIGDSRAVLAQAidsPDALLATRDHKPQTPSERQRIEAAGGFVAGN-----RVCQSLAVSRAFGDFSFKDpnikpeeH
..  |.|   .|| .   ||. ..|||||.| .     .|   ||||.|.   |..|| ||||.|. |     .|   ||..|..||. .|        .
llssGttatvsllrdGtelvlaslGdsrailcrn...GkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkr.......y

MVTCIPDITIVPR-NENLEFIILACDGVWDVLRSETVVGMVREELLSEAALDAVCQTvvmdALQRGSSDNISCCILTL
 |   |.   .    ..  |..|  ||. .|. |. .  .||     | | .|....    ||| || || .. .. |
GviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvrlchdpeeaahalteq....alqygsednatavvvpl
subfamily_PPM1L_pd Subfamily PPM1L 34-302 9e-43 139.4 In-house 10-266 (269) alignment 
Range on Protein: 34-302
Range on HMM: 10-266/269.0
CGIQGYRRNMEDAHILNNDLlEDGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQVSDRSALTD-DALEQLMIDACKSTDHDLPSHIpnfRTVEDM
  ..| | .|||  ....|. ... |  ..|  |||||  ||  | . |.... . | ..      |   . ..|. |   | |..|  ..   .. ||.
ysvlGrrprmedrfeieedi.knktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdeklleka...kraedi

edPGSTCVGALLLEDRLVVFNIGDSRAVLAQAidSPDALLATRDHKPQTPSERQRIEAAGGFVAGN---RVCQSLAVSRAFGDFSFKDPNikpeehMVTC
   |.|.. ||. |. |.| |.|||| || .   .  |.  . ||||| . ||.||. ||||.| .   ||   ||.|||.||. .|| |      .|  
..aGttalialvqesdlivanvGdsrGvlydk..rGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdkn......lvia

IPDITIVPRN-ENLEFIILACDGVWDVLRSETVVGMVREElLSEAALDAvcQTVVMDALQRGSSDNISCCILTL
 |||     .  . ||.|||.||.|| .  |  | ...|. |.|  . |  ...|... .||| |||.  ...|
dpdiltfdlddhkpeflilasdGlwdtfsneeavrfiker.lkepdfGa..kslvlesfkrGsvdnitvlvvkl
subfamily_PPM1E_pd Subfamily PPM1E 35-303 1e-42 139.2 In-house 10-263 (265) alignment 
Range on Protein: 35-303
Range on HMM: 10-263/265.0
GIQGYRRNMEDAHILNND---LLE--DGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQVSDRSaltddaleQLMIDACKSTDHDLPShipnfRTV
 ... || ||| |.  .|   |.|  | .     | .|||||  ||  ||. |.. ..   .. .|          . . .| | ||. . .     ...
avknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa........ealkeafkltDerflq.....kae

EDMEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDspdALLATRDHKPQTPSERQRIEAAGGFVA---GNRVCQSLAVSRAFGDFSfkdpnikpEEHM
..    ||| | .|. .|.| |  .|||.|.| . ..   |.  .. |||. . |..|||.|||.|      ||  .|.|||| || .        ....
reklksGstavvvliekdqlyvaWlGDsqallvrkge...avqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvk........lkpy

VTCIPDITIVPRNENLEFIILACDGVWDVLRSETVVGMVREELLSEA-ALDAVCQTVVMDALQRGSSDNISCCILTLD
|.  .|.. |. ... |..||||||.|||.. |.|| .|.| | ..|  |. | ...|  | ..||||||.  .  ||
vsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfld
subfamily_PPM1D_pd Subfamily PPM1D 35-198 2.7e-19 62.4 In-house 8-174 (309) alignment 
Range on Protein: 35-198
Range on HMM: 8-174/309.0
GIQGYRRNMEDAHILNNDLLEDGS--GLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQVSDRSALTDDALEQLMIDACKSTDHDLPSHiPNFRTvEDM
  || |. |||   .  .  | .   .   .|  |||||. ||  | . | ...      .|. ..   .|...  ..  ..  . | .  |. ..  ..
adqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeW.pktks.gll

EDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAID---SPDALLATRDHKPQTPSERQRIEAAGGFVAGN
   |.|.   .. ...| | ..|||..||..  .   .  |   |.||||..|.|..||| .|| || .
staGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
subfamily_ILKAP_pd Subfamily ILKAP 37-301 1.9e-41 135.1 In-house 13-291 (293) alignment 
Range on Protein: 37-301
Range on HMM: 13-291/293.0
QGYRRNMEDAHILNNDLLED-------GSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQvSDRSALTdDALEQLMIDACKSTDHDLPSHIpnfRTV
.| | .|.|||.. .|| |.        | .   |. |||.|. |.  ||. | .|. . | . || || .   . . ..|. | ||... .     .  
kGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpk.sdvsake.keikkclvdsfkktdeefLkla...ska

EDMEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDSPD---ALLATRDHKPQTPSERQRIEAAGGFVAGNRVCQSLAVSRAFGDFSFKDpnikpeeHM
. .   ||| .  | |.. | | |.|||.|||..  ...|   ..  |.||.| .  ||.||. |||.|  .||   | |||. ||  ||          
kPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkr.......lG

VTCIPDITIVPRNENLEFIILACDGVWDVLRSETVVGMVREELLSE----------------AALDAVCQTVVMDALQRGSSDNISCCILT
|.. ||.. .  .||  |..|||||.|.|.. . ||  . . | .|                . ....|. .  .|..||||||..  .. 
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvllvk
subfamily_PP2D1_pd Subfamily PP2D1 40-103 1.7e-07 23.3 In-house 14-76 (492) alignment 
Range on Protein: 40-103
Range on HMM: 14-76/492.0
RRNMEDAHILNNDLLEDGSgLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQVSDRSALTDDA
. .|||.. | .. ..|      ..  ||. |..||  ||..|.. ..  | .| .|  || . 
KskmeDkrtlqdyfgndvn.scFfgiyDGynGataAeiaakelhevlleelekvdervslttav
subfamily_KAPP-like_pd Subfamily KAPP-like 42-302 7.3e-24 77.2 In-house 11-266 (266) alignment 
Range on Protein: 42-302
Range on HMM: 11-266/266.0
NMEDAHILNNDLLE-----DGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQ-VSDRSALTDDALEQLMIDACKSTDHDLpshipnfrtvEDMEDP
.||| ..    ||.     . | . |.| .||| |. || .| . .|...   |..   |          .|. .| |. |  |          .| |  
emedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdakl..........kdfeye

GSTCVGALLLED---RLV-VFNIGDSRAVLAQAIDSpdaLLATRDHKPQTPSERQRIEAAGGFVAGNRV-CQSLAVSRAFGDFSFKDPNIKPEEHMvTCI
|.|   ||. .|   |.. | |.||| | |..  .|   |  . ||| . |.|.|||   |  .. |.   . ||||||.||   |. ||    .     
GatatlalvwsdGqqrylqvanvGdssaflsrGnes...lelskdhkakdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGlisep.yvs

PDITIVPRNenlEFIILACDGVWDVLRSETVVGMVREELLSEAALDAVCQTVVMDALQRG-SSDNISCCILTL
. |.. | .   .|.|.| ||.|||.  .  . .|.     .|. | ......  |.|   . ||.|  ...|
nrilltpfd...kflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 42-302 1.5e-22 72.8 In-house 10-276 (276) alignment 
Range on Protein: 42-302
Range on HMM: 10-276/276.0
NMEDAHILNNDLLE-----DGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRqvSDRSALTDDALEQLMIDACKSTDHDLPSHIPNfrTVEDMEDPG
.||| ..    ||.     . | . |.| .||| |. || .| . .|...   |.  |   .||..      |   .    || ... .   ..| |  |
emedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllk..sgnysltkqddGGdniydqskllldlfkevda..klkdfeyeG

STCVGALLLEDR----------LVVFNIGDSRAVLAQAIDSpdaLLATRDHKPQTPSERQRIEAAGGFVAGNRV-CQSLAVSRAFGDFSFKDPNIKPEEH
.|   ||. .|           | | |.||| | |..  .|   |  . ||| . |.|.|||   |  .. |.   . ||||||.||   |. ||    .
atatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGnes...lelskdhkatdpeekqrikddGitlsdnqtrinGlavsralGdhfikelniGlise

MvTCIPDITIVPRNenlEFIILACDGVWDVLRSETVVGMVREELLSEAALDAVCQTVVMDALQRG-SSDNISCCILTL
     . |.. | .   .|.|.| ||.|||.  .  . .|.     .|. | ......  |.|   . ||.|  ...|
p.yvsnrilltpfd...kflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
PP2C_SIG_SM00331 50-300 5.6e-09 28.9 In-house 20-215 (217) alignment 
Range on Protein: 50-300
Range on HMM: 20-215/217.0
NNDLLEDGSGLVLIACLDGHG-GRAAALSAAhdlpqKVAAALRQ-------VSDRSALTDDALEQLmidackstdhdlpshipnfrtvEDMEDPGSTCVG
. |..... | .|..  ||.| | |||. ..     ..  |||.       .|.    ...|....                      .. .. . |.. 
yydvvklnegrlllvvaDgmGkGlaAaaass.....qlrtalrellsegeelsqalkrlnraiyee......................keekgmfaTlll

ALL--LEDRLVVFNIGDSRAVLAQaiDSPDALLATRdhkpqtpserqrieaaggfvagnrvcqslavsrafgdF-----------Sfkdpnikpeehmvt
||.   ...| ..|.|||| .| .  |.      .                                                  |              
alydfssgklsyanaGdsrpyllr..dgklveilkd.....................................vegaplGlepevs..............

ciPDITIVPRNEnLEFIILACDGVWDVL-----RSETVVGMVREEL-LSEAALDA-VCQTVVMDALQRGSSDNISCCIL
  .||. .  ..  ....|. ||....      . |.. ..... .  . ..|..   . ..  | ... .|.|.  ..
..vdirelelek.gdllllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvv
PP2C_2 Protein phosphatase 2C 56-267 2e-12 39.9 Pfam-A 20-192 (212) alignment 
Range on Protein: 56-267
Range on HMM: 20-192/212.0
DGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQVSDRSALT--DDALEQLMIDACKSTDhdlpSHIPNFRTVEDMEDPGSTCVGALLLEDRLVVFN
. |.  |.|  ||.| .. .  .|  . . .. ||..  ......  ...|.|.  .. .|..        .  . |...| ..|.. |.. ....|.|.
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk....lkqeaeaqqeelkdyatTlllavitpgeivffq

IGDSRAVLAQaidspdallatRDHKPQTPSERQRIEAAGGfvagnrvCQSLAVSRAFGDFsfkdpnikpeehmvtcipDITIVPrNENLEFIILACDGVW
|||...|. .           ||.. | ..|..  |.|.         ..|  . |....                  .| ... .| .. ..|  |||.
iGDgaivvrd...........rdgevqllgepdsgeyane.......ttfltsedaeeel..................rirrlk.lepgdalllmTDGvs

DVLRSETVVGMVRE
| ||.|. .  . .
dslrkeepfrella
PP2C_2 Protein phosphatase 2C 56-267 2e-12 39.9 In-house 20-192 (212) alignment 
Range on Protein: 56-267
Range on HMM: 20-192/212.0
DGSGLVLIACLDGHGGRAAALSAAHDLPQKVAAALRQVSDRSALT--DDALEQLMIDACKSTDhdlpSHIPNFRTVEDMEDPGSTCVGALLLEDRLVVFN
. |.  |.|  ||.| .. .  .|  . . .. ||..  ......  ...|.|.  .. .|..        .  . |...| ..|.. |.. ....|.|.
easdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk....lkqeaeaqqeelkdyatTlllavitpgeivffq

IGDSRAVLAQaidspdallatRDHKPQTPSERQRIEAAGGfvagnrvCQSLAVSRAFGDFsfkdpnikpeehmvtcipDITIVPrNENLEFIILACDGVW
|||...|. .           ||.. | ..|..  |.|.         ..|  . |....                  .| ... .| .. ..|  |||.
iGDgaivvrd...........rdgevqllgepdsgeyane.......ttfltsedaeeel..................rirrlk.lepgdalllmTDGvs

DVLRSETVVGMVRE
| ||.|. .  . .
dslrkeepfrella
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 57-200 7.1e-17 54.8 In-house 17-153 (292) alignment 
Range on Protein: 57-200
Range on HMM: 17-153/292.0
GSGLVL-IACLDGHG--GRAAALSAAHDLPQKVAAALRQVSDrsalTDDALEQLMIDACKSTDHdlpshipnfRTVEDMEDPGSTCVGALLLED-RLVVF
 . | .  | |||||  |.. |  |.  | ...    ||  .    . .|| . ..| .   |.          |..  |  ... | |   .| .|.. 
sealtflaavldGhGvnGdkvaqlaedtlevelleltrqlqe....lsealllrildiaakldk.........ltidaresattavvcarvrddralila

NIGDSRAVLAQAIDSPDA--LLATRDHKPQTPSERQRIEAAGGFVAGNRV
|.|||||.| ...   |      .|||||. | ||.|| .|||.|   ||
nvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrv
subfamily_PPM1H_pd Subfamily PPM1H 106-189 3.6e-06 19.0 In-house 134-211 (404) alignment 
Range on Protein: 106-189
Range on HMM: 134-211/404.0
QLMIDACKSTDHDLPSHIPNFRTVEDMeDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDSpdaLLATRDHKPQTpsERQRIE
.|.| |  |   .. . | . |.   .   | | . ||.|...| | | |||||.| .  ..       .|. |.|  ||||. 
eLviGalesaflemDeqiarereayri.kGGCtalvalvllgklYvanaGDsRailvrkdei...iplsadftPet..eRqRlq
subfamily_TAB1_pd Subfamily TAB1 119-285 7.8e-11 34.3 In-house 113-298 (333) alignment 
Range on Protein: 119-285
Range on HMM: 113-298/333.0
LPSHIPNFRTVEDMEDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDSPDALLATRDHKPQTPSERQRIEAAG---GFVAGNRVCQSLAVSRAFGDFS-
 |..| .....|.    |.| | ||.. . | | |.|||||.| .  .| .      ||. . . | .|..  |     .  |..  |    |. ||.. 
ypekierlqeleeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykv

---FKDPNI--KPEEHMVTCIPDITIV-PRNENLEFIILACDGVWDVLRSE---------TVVGMVREELLSEAALDAVCQTVVMD
   .|| .|  . ... |   |||.   | ..   |..|  |||   |.            .. .|  ||  .| |..| | || .
kkgykdvdilssakgePviaePdiqgaypiddityflvlmSdGvyktLeevtgpetsnvenillevitelekqatlqdvAqavvdk
subfamily_PPM1G_pd Subfamily PPM1G 133-289 2.9e-39 128.3 In-house 294-451 (473) alignment 
Range on Protein: 133-289
Range on HMM: 294-451/473.0
EDPGSTCVGALLLEDRLVVFNIGDSRAVLAQAidsPDALLATRDHKPQTPSERQRIEAAGGFVA-GNRVCQSLAVSRAFGDFSFKD-PNIKPEEHMVTCI
|| |.| | ||| |..|.| |.||||.||...     ||    ||||. . |..|||.||| |    ||   | .|||.||...|   .....| |.. .
edsGttAvvaLlkekklivAnaGDsRcvlsrn...GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAl

PDITIVPRNENLEFIILACDGVWDVLRSETVVGMVREELLSEA--ALDAVCQTVVMDALQR
||| .    |. ||..|||||.|.|. |. ||  ||..|  .    | .......  .|  
PDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclap
subfamily_PDP_pd Subfamily PDP 135-278 1.5e-17 56.8 In-house 152-321 (398) alignment 
Range on Protein: 135-278
Range on HMM: 152-321/398.0
PGSTCVGALLLEDRLVVFNIGDSRAVLAQAIDSP--DALLATRDHKPQTPSERQRIEAA------GGFVAGNRVCQSLAVSRAFGDFSFKDPN-------
 |.... ||. .. | | |.||.||||..  ..    |   ..|.  ....| .||...         .  .|.  .|. .|||||. .| ..       
sGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvl

-------IKPEEH----MVTCIPDITIVPRNENLEFIILACDGVWDVLRSETVVGMVREELLSEAALDAV
       ..|...     .|  |..|  . .||  |..|| || ||.|..|.|| .| | | .... . |
ekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehlakkkekepv
subfamily_PP2D1_pd Subfamily PP2D1 149-268 4.5e-15 48.3 In-house 190-305 (492) alignment 
Range on Protein: 149-268
Range on HMM: 190-305/492.0
LVVFNIGDSRAVLAQAidsPDALLATRDHKPQTPSERQRIEAAGGFVAGN----RVCQSLAVSRAFGDFSfkDPNIKpeeHMVTCIPDITIVPRNENLEF
| . |.|. .||| ..     |   ||.| |. . ||.|.| ||. |  .    .|   | . |  | .   ||..|   . | . | .| |. .|.  |
lyianaGnvqAvLcre...GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG..dpkLk...ksvipePkttsvkldeaaqf

IILACDGVWDVLRSETVVGMVREE
..||  |.|.||  | |. .|.. 
lvlAsnGlWevlseeevlsLvkqt
subfamily_PHLPP_pd Subfamily PHLPP 149-275 2e-06 19.9 In-house 107-222 (246) alignment 
Range on Protein: 149-275
Range on HMM: 107-222/246.0
LVVFNIGDSRAVLAQAIDspdALLATRDHKPQTPsERQRIEAAGGFVAG-NRVCQSLAVSRAFGDFsFKDPNIKPEEHMVTcipditiVPRNENLEFIIL
| | ..|   |||.        |  .. .. ..  | .||  | ...   |..   .. .| .| . |  | . |. |.         |. .|. |..|.
LevAsvGtlqavliRngk...klrlsksyviekd.elkrikeakaiitednkingviestrllGyt.flfPvvlPkphvre.......vlLteqdelliv

ACDGVWDVLRSETVVGMVREELLSEAAL
  . .|.||  . .|  ||.|  . .| 
GnkalWevlsideaveavrkeedplvaA
Subfamily Dicty-PPM1L-like 184-303 3.1e-08 25.8 In-house 182-304 (305) alignment 
Range on Protein: 184-303
Range on HMM: 182-304/305.0
ERQRIEAAGGFVAGN---RVCQSLAVSRAFGDFSFKDPNIKPEEHMVTCIpditivpRNENLEFIILACDGVWDVLRSETVVGMVREELLSEAA------
.| ||| ... .      .| . | .||  || . |   | ...  .  .        . | .|..|| ||.|.||  . ||. |.| |  .        
iririeslqaalynygellvnrllkksrskGdknlkelviPnndspllvv.......akanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiew

-LDAVCQTVVMDALQRGSSDNISCCILTLD
  . . . .|  |..||| |||   |. | 
dfneisrviveeavkrgsgDnitlviiklk
subfamily_PPM1H_pd Subfamily PPM1H 198-277 9.7e-09 27.4 In-house 275-359 (404) alignment 
Range on Protein: 198-277
Range on HMM: 275-359/404.0
NRVCQSLAVSRAFGDFSFKDPN----IKPeehMVTCIPDITIVPR----NENLEFIILACDGVWDVLRSETVVGMVREELLSEAALDA
.|. . ..|.| .|| . |  .    |||   .... |.....      ... . .||| ||.||||  |.|  .||| | .    | 
aRllatigvtRGlGDheLkvvdtnlsikP...fLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedk
subfamily_PPM1D_pd Subfamily PPM1D 204-302 7.2e-13 41.3 In-house 201-307 (309) alignment 
Range on Protein: 204-302
Range on HMM: 201-307/309.0
LAVSRAFGDF-SFkdpNIKPEEHMVTCIPDITIVPRNENLE-FIILACDGVWDVLRSETVVGMVREELLSEAAL----DAVCQTVVMDALQRGSS-----
|||.|. ||. |.   | | .|..|   ||.. . .. | | ||||| ||.|.|| .|..| .|..|   .         | ...|  |||| .|     
LavaRslGDlWsy...naksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNISCCILTL
||.|  ...|
Dnvsvivvil
PPM_PTC7_SpoIIE_motif 244-302 3.6e-07 23.8 In-house 14-80 (81) alignment 
Range on Protein: 244-302
Range on HMM: 14-80/81.0
FIILACDGVW-------DVLRSETVVGMVREEllSEAALDAVCQTVVMDALQRG---SSDNISCCILTL
 ..|..||..       ...  |... .....  ..  |. .....| ..|..|   ..|.|.  .| .
vllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvlrv
PPM_PTC7_motif 246-295 2.8e-13 43.1 In-house 1-51 (51) alignment 
Range on Protein: 246-295
Range on HMM: 1-51/51.0
ILACDGVWDVLRSETVVGMVREELLSE-AALDAVCQTVVMDALQRGSSDNI
|||.||.|||| ....|..||..| ..   .  ... .| .||.|||.|||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni