Gene ALP-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP001_AA protein Get Run
NvecP001_AA_31-504 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_AP_pd Subfamily AP 31-507 1.6e-186 611.2 In-house 3-470 (472) alignment 
Range on Protein: 31-507
Range on HMM: 3-470/472.0
NNQWFKDGVSTVKKHLLQRPNTKPAKNLIIFVGDGCDINTNTAGRILKGQLKGQVGEKGWLSYEEFPYTGLSKTYTTNRQGSDSAGTANAMFTGVKTRSA
...|.|.. ...|..| ...|.| |||.|.|.|||....| ||.|||||||||..||. .|..|||||.||||||....| .|||.||.|...||||...
akfwlkkaqeelkealelqsnskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktnng

MIGVNEEVVTNKCETLTeDRKVDSILKLAEEAGMATGFITSMRLTHATPANLYAHSASRYWESDKEMVSRGYgNTSCKDMAQQLVdfQGSVGDGIEVVMG
.|||...| ...||... ...|||||. |..||.|||..|..|.|||.||.||||.|.| ||||.|. ...  ...|||.||||.  . .||. ..|..|
tiGvdaaverkdCeasa.gkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeae.kegckdiaqQLi..eeevgkeldvilG

GGRRSFLPNTTRDPEHVNKtGERYDGRNLIQEWLNKREGSVYAWNKTQFDAVDPKTTKHFLGMFESSHMQFAIDRdeDVGGEPSIAEMVEKAVSILKNND
|||..|||.|..|.|. .| ||| ||||||.|| .......| .|......||...|...||.|..||....|||  |  .|||..||.|||...|..|.
GGrkkflpktvkdseyekk.gerkDgrnLieewekekknakyvenrkelenvdksktdrllGlfadshlkyeidr..dekeePsLkemtekAlevLskne

NgkGFFLAVEAGLIDIGHHNGIARQALNEVVNLEEGVAKAVEMTDKEDTLIISTADHGHVFTLTGYPDINSPIFGLMKQdgevkLALNDNKPYTILGYMN
|  |||| ||.|.||..||.. |..||.|.....| |..|.|.||.|||||..||||.|..|..|||. .|.|.||.|.        .|..|||.| |.|
n..GffLfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglake.....sksadelpyttlsyan

GPGAVK-------GVRANLTGVDTGAKDFKQQALyIGYDyDEAHGSQDVGIYSRGPWAHLLTGVVEQNVIFHVMDHALCLSSSK
|||...       | |..|| ..|.|||...||. .... .|.||..||..|..||..|||||||||. | |||..|.||.. .
gpgyeltesdleegerkdlteaeteakdyvsqaa.vple.eetHggeDvavyasGpqshlltGvveqstiahvmayaaclgeae
0037220 Alkaline phosphatase-like 32-504 8.3e-135 440.3 In-house 10-469 (479) alignment 
Range on Protein: 32-504
Range on HMM: 10-469/479.0
NQWFKDGVSTVKKHLLQRPNTKPAKNLIIFVGDGCDINTNTAGRILKGQLKGQVGEKGWLSYEEFPYTGLSKTYTTNRQGSDSAGTANAMFTGVKTRSAM
. ..   . ..  .||. .|.. |||.|.|.|||....| || ||..|||.|. || |.|....||..||.||| .... .|||..| |..|||||   .
llllllalallllalllllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlatGvKtnnga

IGVNEEVVTNKCETLTEdRKVDSILKLAEEAGMATGFITSMRLTHATPANLYAHSASRYWESDKEMVSRGYGNTsCKDMAQQLVdfqgsVGDGIEVVMGG
|||. .|....|.. .. ..|..||.||.|||.|||..|. |.|||||| .|||.|.| ||.| ..   |...  |||.|.|||     .|.|..|..||
igvdadvsrdncddplg.npvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleag.ckdiatqlv.....lgsgldvilGG

GRRSFLPNTTRDPEHVNK---TGERYDGRNLIQEWLNKREGSVYAWNKTQFDAVDP-KTTKHFLGMFESSHMQFAIDRdeDVGGEPSIAEMVEKAVSILK
||. |||..| |||. ..   .| |.|||.|..|. .|..|  |..|....||.|. ......||.|..||.....||  |. .|||.|||.|||...|.
GrkyflpkgtldpeydlelllggkrldgrdlleeakekkkgytyvtnreeldaldlgsnvdkllGlfadshlpyeldr..daseePsLaemtekAldlLs

NndNGKGFFLAVEAGLIDIGHHNGIARQALNEVVNLEEGVAKAVEMTDKEDTLIISTADHGHVFTLTGYPDINSPIFGLMkqdgevKLALNDNKPYTILG
.  | ||||| ||.| ||...|.. |. ||.||. ..| |. |.|.....|||.. ||||.|.....||.| ..||.||.      .  | |..||| | 
k..ndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgll......pgllldglpyttll

YMNGPG--AVKGVRANLTGVDTGAKDFKQQALYiGYDYdEAHGSQDVGIYSRGPWAHLLTGVVEQNVIFHVMDHALCLS
| ||||  .. ..| .|| ..| |... |.||. |..  . |. .|| .| .||.|.|..||.|.. |.||. .||.|.
yangpgflllldlrldltllvtlallllqralv.gwts.ggHtgedVpvyayGpgaelflgvyentdiahviasalglg
Alk_phosphatase Alkaline phosphatase 55-503 6.3e-117 381.6 Pfam-A 1-421 (421) alignment 
Range on Protein: 55-503
Range on HMM: 1-421/421.0
AKNLIIFVGDGCDINTNTAGRILKGQLKGQVGEKGwLSYEEFPYTGLSKTYTTNRQGSDSAGTANAMFTGVKTRSAMIGVNeevvtnkcetlTEDRKVDS
|||.|...|||    | || |.||.| ||..||.  |  ...|..||||||....|  |||.|| |. .||||    |||.           |....| |
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd...........thgkevks

ILKLAEEAGMATGFITSMRLTHATPANLYAHSASRYWESDKEMvSRGYGNTSCKDMAQQLVDFQgsvgDGIEVVMGGGRRSFLPNTTRDPehVNKTGERY
.|. | .|| .|| .|  |.|||||| |.||.||| ||.| .. .    .  .||.|.||.. .      |.|..||||. |||..|.|.   ...| | 
vleaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaat.aasakkeGkkdiaeqlikak....kkidvllGGGrkeflptgtkde..ekerGtrl

DGRNLIQEWlnKREGSVYAWNKTQFDAVDPKT-TKHFLGMFESSHMQFAIDRDEDvgGEPSIAEMVEKAVSILKNNDngKGFFLAVEAGLIDIGHHNGIA
||||||.|.  |..|. | ...... ..  .  .|..||.|. ........|||.   |||..||.|.|. .|. |.  ||||| || . || ..|.. |
dgrnlieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdek..eePsLkemtevAiklLskne..kGFFLlVEGsrIDhaaHenda

RQALNEVVNLEEGVAKAVEMT-DKEDTLIISTADHGHVFTLTGYPDINSPIFGLMKQdgevkLALNDNKPYTILGYMNGPGAV-K-GVRANLTGVDTGAK
 .||.|||...| |..|.|..  ...||...|||| |||...||.  .. |.||..      .. .| |..... | ||.||  . |.|.|.|  ....|
vgalsEvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaa.....kktkdgkakklilygngegakvedgarenvtaeealek

DFKQQAlYIGYDyDEAHGSQDVGIYSRGPWAHLLTGVVEQNVIFHVMDHALCL
 .....  .|..  | |...|| .. .|| |.|..|| ||. |..|.  ||.|
iyrkrs.avglt.seeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Alk_phosphatase Alkaline phosphatase 55-503 6.3e-117 381.6 In-house 1-421 (421) alignment 
Range on Protein: 55-503
Range on HMM: 1-421/421.0
AKNLIIFVGDGCDINTNTAGRILKGQLKGQVGEKGwLSYEEFPYTGLSKTYTTNRQGSDSAGTANAMFTGVKTRSAMIGVNeevvtnkcetlTEDRKVDS
|||.|...|||    | || |.||.| ||..||.  |  ...|..||||||....|  |||.|| |. .||||    |||.           |....| |
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd...........thgkevks

ILKLAEEAGMATGFITSMRLTHATPANLYAHSASRYWESDKEMvSRGYGNTSCKDMAQQLVDFQgsvgDGIEVVMGGGRRSFLPNTTRDPehVNKTGERY
.|. | .|| .|| .|  |.|||||| |.||.||| ||.| .. .    .  .||.|.||.. .      |.|..||||. |||..|.|.   ...| | 
vleaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaat.aasakkeGkkdiaeqlikak....kkidvllGGGrkeflptgtkde..ekerGtrl

DGRNLIQEWlnKREGSVYAWNKTQFDAVDPKT-TKHFLGMFESSHMQFAIDRDEDvgGEPSIAEMVEKAVSILKNNDngKGFFLAVEAGLIDIGHHNGIA
||||||.|.  |..|. | ...... ..  .  .|..||.|. ........|||.   |||..||.|.|. .|. |.  ||||| || . || ..|.. |
dgrnlieea..kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerdek..eePsLkemtevAiklLskne..kGFFLlVEGsrIDhaaHenda

RQALNEVVNLEEGVAKAVEMT-DKEDTLIISTADHGHVFTLTGYPDINSPIFGLMKQdgevkLALNDNKPYTILGYMNGPGAV-K-GVRANLTGVDTGAK
 .||.|||...| |..|.|..  ...||...|||| |||...||.  .. |.||..      .. .| |..... | ||.||  . |.|.|.|  ....|
vgalsEvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaa.....kktkdgkakklilygngegakvedgarenvtaeealek

DFKQQAlYIGYDyDEAHGSQDVGIYSRGPWAHLLTGVVEQNVIFHVMDHALCL
 .....  .|..  | |...|| .. .|| |.|..|| ||. |..|.  ||.|
iyrkrs.avglt.seeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Phosphodiest Type I phosphodiesterase / nucleotide pyrophosphatase 331-441 7.5e-06 15.0 Pfam-A 183-289 (365) alignment 
Range on Protein: 331-441
Range on HMM: 183-289/365.0
NgKGFFLAVEAGLIDIGHHNGI-ARQALNEVVNLEEGVAKAVEMTDKE----DTLIISTADHGHVFTltgypdINSPIFGL---MKQDGEVKLALNDNKP
.   ..| . ..|  .||. |  . .. . . .. . ... .|  |..    .|.|| ..|||   .      .|.  . |   ....|. ||. .|  .
r.pdlllvylselDsvgHkfgpdspevedalrrvDraigeLlealdergllentniilvSDHGmadv......lnkkvidlnellrlegllkldeddire

YTilgymNGPGAVKGVRAN
|.     .. ||.......
ya.....ldegalaaikpk