Gene PPP2C in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP115_AA protein Get Run
NvecP115_AA_4-296 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP5C_pd Subfamily PPP5C 4-292 9.9e-86 280.6 In-house 14-308 (322) alignment 
Range on Protein: 4-292
Range on HMM: 14-308/322.0
DKTTAKDLEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCP----VTVCGDVHGQFHDLMELFRIGGK-SPDTNYLFMGDYVDRGYYSVETV
.| | . ..  .|.. . |.| .  . ..  .|||.|.|.. . |.. .    .|||||.||||.||...|.. |. |..  ||| ||.|||| .|||..
ekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsvevi

TLLVTLKVRFPHRICILRGNHESRQITQVYGFYDECLRKYGNaSVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSI-DTLDHIRALDRIQEVPHEGPMC
 .|...|. .|... . |||||| .. ..||| .|.  || .  | . ||..|..|||. ....... .||||  .   |||..| .|| .. |.|| ..
ltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakyte.kvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllv

DLLWSDPDDRGGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL-DDALKYSFLQFDP
.||||||... | . | || | .|| |... | ..|.|.|| |.|.. .|||.  || ...|.||||||| . ||..|...| .| ||  | .|. 
ellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea
0049330 Metallo-dependent phosphatases 5-296 6.6e-115 376.3 In-house 11-302 (309) alignment 
Range on Protein: 5-296
Range on HMM: 11-302/309.0
KTTAKDLEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTL
. . ..|...||.|. .|.|.| ....|..|||||| .|.|..|.. ...|.||.|||..||..|... |  |.....|.||.||||..|.|...||  |
elilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllal

KVRFPHRICILRGNHESRQITQVYGFYDECLRKYGnASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDP
|...|... .||||||.|.....|||.||.||||| |..|..|.|....|||.|.....|.| ||||||.. .||.||.|.| .|.|..|..||||||||
kllypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdp

D-DRGGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPRR
. .| |.. .|||.|..|| .. | | ..|||.|| |.|..|..|| ...|....|.|||||||.|.||..|..|.|. |..|||.|.|.|. 
lpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
0053225 Metallo-dependent phosphatases 5-294 1.9e-110 361.7 In-house 3-292 (293) alignment 
Range on Protein: 5-294
Range on HMM: 3-292/293.0
KTTAKDLEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTL
...  .|...||.|. .|.|.| ....|...|||||.||.|..|.. ...|.||.||...||..|... |  |.....|.||.||||..|.|...||  |
slilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllal

KVRFPHRICILRGNHESRQITQVYGFYDECLRKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDP
|...|... .||||||.......|||.||.|||||.|..|....|....|||.||....|.. ||||||....||.|| ..| ...|.||...|||||||
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp

DDRGGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAP
|.. ||..|.||.|..|| .. . | ..|||.|| |.||.|..|| ...|...||.||||||..|.||..|...||. |...| .|.| .
dlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 5-294 7.5e-101 330.1 In-house 5-295 (298) alignment 
Range on Protein: 5-294
Range on HMM: 5-295/298.0
KTTAKDLEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTL
.  .. |.| ...   .|...|..|..|.|.||.|..| . . ||. |..||||.|||. ||. ||  .|  ||.||||.||||||| ...|...||.. 
ellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllay

KVRFPHRICILRGNHESRQITQVYGFYDECLRKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDP
||..|... .||||||  .| .|||||.|| |.| . .... | |.|. ||||||. ..|.|.|||||. . .||..|.| | .. ..|    ||||.||
kvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadp

DD-RGGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAP
..   ||  . ||....||.|  . . ..  . |..||||.| .||..  ....|||||||.|| .  | ||.|..|. |. ||  . |. 
enavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_PPP3C_pd Subfamily PPP3C 5-281 4.7e-90 295.5 In-house 22-311 (452) alignment 
Range on Protein: 5-281
Range on HMM: 22-311/452.0
KTTAKDLEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTL
.|    |||  | ...  .|.|...  . |.| ..|.||... ||. |.||.||.||||.||..|| .||.  .|.|||.||||||||.|.|.|  | .|
etgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyal

KVRFPHRICILRGNHESRQITQVYGFYDECLRKYGNaSVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDP
|. .|... .||||||.| .|. . | .||  ||.. .|.. ... || |||.||...| .|.|||||| | .|| |. ||| .|.|. ||.||||||||
kiaypstlfllrGnhecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdP

DDRGGWGI--------SPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHD------RNVVTIFSAPNYCYRCGNQAAIMELDD
 .. |           |.||  | ..   . .| ..| |  | |||.   .||.  ..        ..|.||||||.    |.||......
ledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
0045823 Metallo-dependent phosphatases 7-295 1.8e-122 402.3 In-house 26-326 (473) alignment 
Range on Protein: 7-295
Range on HMM: 26-326/473.0
TAKDLEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKV
.  ||...||.|.....|.| ... |...|||||.||.|..|.. ...|.||.|||..||..|... |  |.....|.||.||||..|.|.. ||  ||.
glldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalki

RFPHRICILRGNHESRQITQVYGFYDECLRKYgNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD
..|... .||||||.|.....|||.||.|.|| .......| .....|||.|.....|.. ||||||....|| ||...| .|.|..|...|||||||..
kypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwe

RGG--------WGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRN------VVTIFSAPNYCYRCGNQAAIMELDDALkYSFLQFDP
  |        .| |||||||.||.|. | | . |||.|| |.|. |.|||....|..      ..|.|||||||.|.|| ||....|. | .|| ||||
ddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdp

APR
.| 
sph
subfamily_PPP2C_pd Subfamily PPP2C 9-297 3e-193 633.4 In-house 2-290 (290) alignment 
Range on Protein: 9-297
Range on HMM: 2-290/290.0
KDLEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRF
|||. .||.|.|||||.|..||.|||||||||||||||||||||||||||||||||||.|||.||||||||||||.||||||||||||||||||.||||.
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PHRICILRGNHESRQITQVYGFYDECLRKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG
..||.||||||||||||||||||||||||||||.|||||||||||||||||||.|||||||||||||||||.||||||.||||||||.||||||||||||
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPRRG
||||||||||||||.||||.||.|||||||.||||||||||||.||||||||||||||||||||||||.||||.|||||||||||||||
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 9-296 3.7e-90 295.2 In-house 9-297 (299) alignment 
Range on Protein: 9-296
Range on HMM: 9-297/299.0
KDLEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRF
| |.|   .    | . | ...|||. ||... ... . ||. |. ||||.|||. ||. .| . |  ||.|.||.|||||||   .|..|||.  |...
kllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkiky

PHRICILRGNHESRQITQVYGFYDECLRKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-
|.|. .||||||   | .|||||.|| ..|  . .|  | | |...||| |. ..|.|.|||||| ..||| .| | | |. |      ||||.|||.  
perffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsv

GGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPRR
 .|    ||  | ||||. .   .. .. |..||||.| .||..  ....||||||| || .  | ||||..|. |  .|  . |.|..
kdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_PPP7C_pd Subfamily PPP7C 9-187 8.6e-40 129.6 In-house 18-202 (383) alignment 
Range on Protein: 9-187
Range on HMM: 18-202/383.0
KDLEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKC----PVTVCGDVHGQFHDLMELF-RIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVT
...|  ||.. | |.|    | ..  .||..| .  |...|.      ||||||.||.. ||. .. . |  |.. .|.| ||.||||  ||| . .|..
deveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillilla

LKVRFPHRICILRGNHESRQITQVYGFYDECLRKY--GNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDtLDHIRALDRI
| . .|. . . |||||   .   |||  |   ||   .. . . . |.| .|||..|.|..|. .|||.| . | |. .  ..| 
lllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiers
subfamily_PPP4C_pd Subfamily PPP4C 10-294 1.6e-150 493.2 In-house 2-286 (288) alignment 
Range on Protein: 10-294
Range on HMM: 2-286/288.0
DLEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFP
||.  ||.|..|. ..| .||.||.||.||| .|||||.|..|||||||.||||.||.|||..||. |.|||||.||.||||.|||||  ||..||||.|
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

HRICILRGNHESRQITQVYGFYDECLRKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGG
 || ..||||||||||||||||||||||||.|.||.| |..||||.|.|..|..|||.||||||||.|||.||..|| ||||||||.||||||||.|  |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAP
|..||||||| ||.|..|.||..|...||.||||||||||..  ...|.|..||||||||||| |||.|||..|.. |  |. |.
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP6C_pd Subfamily PPP6C 11-291 1.3e-139 457.2 In-house 2-282 (290) alignment 
Range on Protein: 11-291
Range on HMM: 2-282/290.0
LEVWIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPH
|. |||.  .|| |.|...| ||.. ...|..||||| |..|||||||.||||.||.|||| ||. |||.|.|.||.|||||||.||.|.|.|||...|.
ldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypd

RICILRGNHESRQITQVYGFYDECLRKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGGW
|| .|||||||||||||||||||||.|||||..|||.|..|| |...|..|.|..|.|||||| . |||.|| ..| ||.||.|..|||.||||.|   |
ritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvetw

GISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFD
 .||||||| ||. ... |.|.| | ||.||||||.||...  | ..||..||||||||||| |.|..|.|| . ..  |.
avsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPG1_pd Subfamily PPG1 14-295 2.7e-131 430.3 In-house 4-298 (300) alignment 
Range on Protein: 14-295
Range on HMM: 4-298/300.0
WIEQLMECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRIC
 .|.|  .. | |. || |..| ||.| |||||.|...|||| |||||||.|..|.|.|||. |||||||.|||||||.|||||..||..||.|.| || 
cleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsrit

ILRGNHESRQITQVYGFYDECLRKY-GNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD-------
.||||||||||||||||| |||||| ||. ||||.|..|||| |.|..|..|.|.|||||||. ..| |. |||..|||.|| ..|||||||.       
llrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptl

---DRGG--WGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPR
   || |  . .|.|||||..|.|. | | ..| .  | |||||..|||.   |  . |..|||||||||||.|.|.|| . ... |  .. ||.
dhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 18-293 7.1e-87 284.1 In-house 2-275 (280) alignment 
Range on Protein: 18-293
Range on HMM: 2-275/280.0
LMECkqLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRG
|..|  . ||..... || |.||. .. . ||..||.||||.|||. ||. ||   .  ||.||||.||||||| . .| . ||.. |||.| .. ||||
llac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrg

NHESRQITQVYGFYDECLRKYGNAsVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD-DRGGWGISPRG
|||  .| . |||.||. |.| .| ... | .|.| |||.|||  .|.|.|||||. . .||... | |  . ..|    ||||.||. .  ||. ..||
nhevisinrkygfkdevkrrysla.lynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrg

AGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPA
. . ||...   . .   . ||.| ||.| .||..  |...||.||||.|.    |.||.. .|. |. ||  . ||
vsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 19-291 1.3e-79 260.6 In-house 18-293 (297) alignment 
Range on Protein: 19-291
Range on HMM: 18-293/297.0
MECKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGN
. .| .|| .|  | . | ... .. .. ||..|. ||||.|||| ||. ||. ||  | .||||.||||||| .|.||. ||.. ||.||  . .||||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYDECLRKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSP---SIDTLDHIRALDRIQEVpHEGPMCDLLWSDPD-DRGGWGISP
||   . .|||||.|| ..|    ..  | |.|..|||| |. ..|.|.||||||      ||| .| ..| .|  .|. ..||||.||     |.    
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFD
||||  ||.|          | |. ||||.| .||..   |..||||||| || .  | ||.|  |. |. ||  . 
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 21-291 1.2e-84 277.2 In-house 4-281 (284) alignment 
Range on Protein: 21-291
Range on HMM: 4-281/284.0
CKQL-TEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKS------PDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRIC
|..| .| ..  || .|.|.. ||.  .|...||...||.|||| ||. |. . |         ...|||.||||||| .|.| .||| ..|...|... 
cqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvf

ILRGNHESRQITQVYGFYDECLRKYGNAsVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGI
.|||||||| . . |||| || ..| .| ... |   |  .||.|.|...|.|.|||.|  .  |. . .|.|  ..|  | ..|| |.||. .  |.  
llrgnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyke

SPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFD
|||||| .||..  . |...  | |. ||||.||.||..  ||..||||||| || .  | ||....|. |  ||  . 
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 21-294 9.5e-72 234.8 In-house 3-276 (280) alignment 
Range on Protein: 21-294
Range on HMM: 3-276/280.0
CKQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHE
|. .|  .. ..    . |. .|||. | ..|. | ||.| |..|.  || . |. |. . .|.|||||||   .| . ||. ||.|.  || .||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGNAsVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGY
.  . ..|||| ||  ||| . .|  |   |. .|...|. ....|.|||||| .  || || . |  |    | . ||||||| ..| ||  | ||  |
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

TFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAP
 ||. . |   ..  . || ||||.| .||.    | ..|.|| |||| .  | ||.. |.  |. || |. | |
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 21-74 3.8e-13 42.3 In-house 5-59 (317) alignment 
Range on Protein: 21-74
Range on HMM: 5-59/317.0
CKQ-LTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGG
|.. ..|...  || .|.|.. ||    |...|||..||.||||.||. |. . |
cqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_PPP1C_pd Subfamily PPP1C 22-291 9.7e-107 349.3 In-house 8-277 (282) alignment 
Range on Protein: 22-291
Range on HMM: 8-277/282.0
KQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHES
 .|.||....|..||.||| ... . |.. ||...||.|||..||. || ..|  |..||||.|||||||  |.||..||...|...|... .|||||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RQITQVYGFYDECLRKYGNAsVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYT
 .|...||||||| |.|..  .|| ||| |..|||.||||..|.|.||||||... |..|| . |  |||..| .|||||||||. . ||. . ||  .|
asinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFD
||.|. |.| . | | || ||||.| .||..  .|..||.||||||| . .|..|....|. |. ||  . 
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 22-292 1.2e-79 260.2 In-house 8-281 (287) alignment 
Range on Protein: 22-292
Range on HMM: 8-281/287.0
KQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHES
. ... .. .. ||..|||   . . ||. |.|..||.|||..||. .|   |..|...|||.|||||||  |.| . || .||...|... .|||||| 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RQITQVYGFYDECLRKYGnASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQ--EVPHEGPMCDLLWSDPDDRgGWGIS---PRG
..| ..|||..|  ||..  ...| | |.|..||| | |...|.|.|||.|| ...|| ..|| . .     .|| . ||||.||.     ..     |.
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkira

AGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDP
    ||.   . . .. .. || |||... |||..  |...||.|||| |. .  | .|.. ....|. || .. |
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 22-292 1e-70 231.0 In-house 14-288 (290) alignment 
Range on Protein: 22-292
Range on HMM: 14-288/290.0
KQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHES
. ... .. .. ||..|||     . ||. |... ||.|||. .|.. |   |. |. ..||.|||||||  |.|   ||  .|.|..... .|||||| 
dafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhev

RQITQVYGFYDECLRKYgNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDR--IQEVPHEGPMCDLLWSDPDD--RGGWGI-SPRG
|.. ..|||..|  ||  .. .|| . |.|. |.| | |...|.|.|||.|. |.. . ..|| .  ..   .|| . ||||.||.        .   |.
rkvnrlygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqra

AGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDP
    ||..  ... .. .| || |||..  ||.|.  |...||.|||| |. .  |  ||... ..|. |.  . |
isvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 22-286 2.6e-58 190.6 In-house 5-294 (302) alignment 
Range on Protein: 22-286
Range on HMM: 5-294/302.0
KQLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPH
|.... .. .|.|.  | |.||... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. .||| .|.
keysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlypt

RICILRGNHESRQITQVYGFYDECLRKYGNAS---VWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDR-IQEVPHEGPMCDLLWSDPDD
.  .||||||.. |   ||| .|   ..|..    .|. | . | ..||.||| ..|.|.|||.|| ...|..|. ..| ..|| ..    |||..|| |
nyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld

RGGWGISPRGAGYTFG--QDISETFNHT--------NGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYS
  .  . ..   |..   ...| .||..         .| || |||| . ||...  |....||||||.|     |. |....|   | |
vqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 23-295 4.9e-83 271.6 In-house 7-279 (281) alignment 
Range on Protein: 23-295
Range on HMM: 7-279/281.0
QLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESR
|.|. .....  ... |.|.|... |.. |..| ||.|.||.|| .|| . |. |.. ..|.|||||||  |.|.. || |||.|...|| .||||||  
qytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheia

QITQVYGFYDECLRKYGNaSVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTF
.. ..|||| ||  |||   .|  |   |. ||..||..... |.|||||| . .||..|   .  . .. | . ||||.|||... .|  | ||...||
svnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftf

GQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPR
|... .    . .. || ||||.|..||.    |...|.||.||||    | ||.. .|..|. |.... ||. 
GknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 23-294 8.2e-68 221.8 In-house 19-293 (307) alignment 
Range on Protein: 23-294
Range on HMM: 19-293/307.0
QLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESR
| |  ... .  .|. |.| |  . ..  |. | ||.|||| ||...| . |. |.| |.| |||||||  |.|.. ||.| |. .|. | .||||||  
qytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheia

QITQVYGFYDECLRKYGN--ASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGY
.. . ||||.||.    .    .|  |   |. ||..||.  .|.|.||||||..  || .|   .    |  | . |.||.|||     |  | ||.|.
rvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgf

TFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAP
||| .. .   .  |. || ||||....||     |...|||||| ||    |  ... .|..|    . | |. 
tfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 23-286 1.6e-58 191.3 In-house 5-293 (302) alignment 
Range on Protein: 23-286
Range on HMM: 5-293/302.0
QLTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSP-----------DTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHR
.... .. .|.|.  | |.||... |.  |||. ||.||||.||. ..    ..               ..|.|||||||. |.| ..|. .||| .|..
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

ICILRGNHESRQITQVYGFYDECLRKYGNAS---VWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDR-IQEVPHEGPMCDLLWSDPDDR
  .||||||.. |   ||| .|   ..|..    .|. | . | ..||.||| ..|.|.|||.|| ...|..|. ..| ..|| ..    |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

GGWGISPRGAGYTFG--QDISETFNHT--------NGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYS
 .  . ..   |..   ...| .||..         .| || |||| . ||...  |....||||||.|     |. |....|   | |
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
PPP_3 24-291 1.5e-119 391.0 In-house 2-270 (271) alignment 
Range on Protein: 24-291
Range on HMM: 2-270/271.0
LTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQ
|.| ..|.|..|.||||.||||..|.. |||||||.|||..||.|||..||.||.|.|||.|||||||..|.|...||..||...|... .|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGYTFG
|..||||..|.|.|.|...|.|.....|..|||.||.|......||||||||..||.|. |.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFD
.|..|.|...| |.|| |||.|..|||. .||..|||.|||||||.|..|..||..|..||...| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_PPZ_pd Subfamily PPZ 24-292 4.8e-80 262.2 In-house 25-293 (300) alignment 
Range on Protein: 24-292
Range on HMM: 25-293/300.0
LTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQ
| ....  .| ||.|..  . .. |.  .| . ||||||. ||. ||   |  | .||||.|||||||  |.||. ||.  |...|  . .||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECLRKyGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFG
.|.|||||||| |.  |  .|| | | |. |||.|.|  .|||.|||||| ....| || . |  .||  | . ||||||| |    |    ||  | . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

QDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDP
.   . |    |. |. ||| .| .||..  ||..||.|||||||    |  |.| . . |  ||  .||
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 24-74 4.8e-08 25.5 In-house 11-61 (339) alignment 
Range on Protein: 24-74
Range on HMM: 11-61/339.0
LTEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGG
.  |..  || .|.|..  |  . ....|. | ||.|||| ||. .. . |
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
PPP_1 25-279 1.6e-117 384.5 In-house 2-264 (264) alignment 
Range on Protein: 25-279
Range on HMM: 2-264/264.0
TEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQI
.|.....|..|.||.|.||.|..||. ..|||||.||||.||..||..||.||.|||||.|||||||..|||...||..||...|... .|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|.......|..||.||.|||.||.|..|...||||||..|.||.|| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL
|||.||.|..|.|...|.|.||.|||....|||.....|.|||||||.||.....|..|...|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PP2Ac_SM00156 25-293 1.6e-110 361.4 In-house 2-270 (271) alignment 
Range on Protein: 25-293
Range on HMM: 2-270/271.0
TEAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQI
.. .|..|.|..||||..|.|. ||. ||||.||.|||..||..|.. .|..|...|.|.|||||||..|.|...||..||...| .. .|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGYTFGQ
...|||..|. ||| ...... |...|..|||.||||..|.|.||||||.. .||.|| |.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPA
|. . | ..| | || |||..|.|||....|...||||||||||....|.||.......|| |. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 26-292 7.6e-75 244.9 In-house 5-273 (284) alignment 
Range on Protein: 26-292
Range on HMM: 5-273/284.0
EAQVKTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQIT
  .|.||  .| .|. |.  . ||. |. .|||.|||| ||. ||   |    .||||.||||||| . .||. ||.. || || .. .||||||   | 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QVYGFYDECLRKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGYTFGQ
..||||.|| |.| . ||.. |  .|  .|||||| ..|.|.|||.|  .. . ..||. |  . |    .  |.||||| . . ||    ||  | || 
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDP
|    .     . |. ||||.| .||..  .| .||||||| || .  | ||.| ..  |  ||. . |
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_PPPLV_pd Subfamily PPPLV 30-279 9.2e-55 179.0 In-house 3-275 (290) alignment 
Range on Protein: 30-279
Range on HMM: 3-275/290.0
KTLCEKAKEILSKESNVQEVKCPVTVCGDVHGQFHDLM----ELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQIT
 .||..| .|| .| .. |.| |. | ||.||...||.     |.|.| .   ...||.||||||| .||| .. |..||| .| .. .|||||| . ..
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

QVYGFYDECLRKYGNA--SVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRI----QEVPHEGPM-CDLLWSDPDDR-----------
. . .. |.  |.|.   .||. |.. ||.|||.| .|...|| |.|.  .| |  .| |.. |    ..  .  |.  |.|||||..            
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvl

--GGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRcGNQAAIMEL
  |    . || |. |..|  |.| . |.|  . |||.   .|..  ..  ..|.||. .||    |.||.. .
neGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilv
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 47-292 1.7e-60 197.9 In-house 3-255 (263) alignment 
Range on Protein: 47-292
Range on HMM: 3-255/263.0
QEVKCPVTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQITQVYGFYDECLRKYGN----AS
 |...|. .||| |||. ||. .|   | .  |.|||.||||||| .|.| . ||..||. .|... .|||||| . | . |||. |  ...       |
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGYTFGQDISETFNHTNGLTLI
|...| ..| |.|| |.| ..|.|.|||.|| . .|| |||.    |  .  |. |||||.||.     |. |   |     ||.   . . .   . ||
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidli

TRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDP
 ||||.|  || .  || ..|.|||  |     | ||.. ..  |. ||.|. |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
Metallophos Calcineurin-like phosphoesterase 52-244 7.4e-43 140.1 Pfam-A 2-198 (200) alignment 
Range on Protein: 52-244
Range on HMM: 2-198/200.0
PVTVCGDVHGQFHDL----MELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLL--VTLKVRFPHRICILRGNHESRQITQVYGFYDECL----------
...|.||.||...||    ..|..|..... ...||.||.|||| .| ||  ||    ||...|...  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLDHIraldriqevphegpmcdllwsdpddrggwgi
                       ..... |.. .. . |..||| ||||..|.. ||.||.| .. | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYTFGQDISETFNHTNGLTLITRAHQL
    ... || |  | .   .|..|. |.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 53-244 2.8e-80 261.7 In-house 1-197 (198) alignment 
Range on Protein: 53-244
Range on HMM: 1-197/198.0
VTVCGDVHGQFHDLMELFRIGGKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQITQVYGFYDECLRKYGNASVWKYFTDLFD
||||||.|||..||..||. |..||...|||.|||||||..|.|...||..||...|... .|||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQL
.|||.||.|......|||||..|..||.|.  .| .|.|.||...||     |..........  | ||||..||.|..|.. ..| |.|| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 53-244 4.6e-76 248.2 In-house 1-196 (197) alignment 
Range on Protein: 53-244
Range on HMM: 1-196/197.0
VTVCGDVHGQFHDL-MELFRIGGKSP-DTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQITQVYGFYDECLRKyGNASVWKYFTDL
|||.||.|||..|| ..|...||. . ...|.|.|||||||..|.|...||. ||...|.....|||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQL
||.|||.||.|......|||||.....||.|....| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.| || |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 53-244 5.9e-75 244.6 In-house 1-198 (199) alignment 
Range on Protein: 53-244
Range on HMM: 1-198/199.0
VTVCGDVHGQFHDL-MELFRIG-GKSPDTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQITQVYGFYDECLRKYGNASVWKYFTDL
||||||.|||..|| ..||. |  .|....|.|.|||||||..|.|...||. ||...|.....||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLPLTALVDNQIFCLHGGLSPSIDTLDHIRALDRIQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGYTFGQDISETFNHTNGLTLITRAHQL
||.|||.||.|......||||||.|..........| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| ..|.| || |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 53-126 3.3e-09 29.6 In-house 12-81 (235) alignment 
Range on Protein: 53-126
Range on HMM: 12-81/235.0
VTVCGDVHGQFHDLMELFR--IGGKSPDTNYLFMGDYVDRGYYSVETVTLLvtlkvRFPHRICiLRGNHESRQITQ
. | ||||| . .|.||.   |||| ..   ...|| ...|  |||.| ..     |  .  | ..||||   . .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv.....rkdqvkc.vkGnheelvlla
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 78-293 1.6e-73 240.6 In-house 100-315 (317) alignment 
Range on Protein: 78-293
Range on HMM: 100-315/317.0
DTNYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQITQVYGFYDECLRKYGnASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDT
  .|||.||||||| .|.| |.||..||...|... .|||||||| . . |||| |. ..|  |.... |   |  |||.|.|...|.|.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrys.aalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAI
|. . .|.|  ..|  | ..|| |.||| .  |.  |.||||  ||..  . |...  | |. ||||.|..||..  ||..|||||||.|| .  | ||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MELDDALKYSFLQFDPA
...|. || |.  . | 
lsvdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 80-295 5.1e-58 189.8 In-house 121-336 (339) alignment 
Range on Protein: 80-295
Range on HMM: 121-336/339.0
NYLFMGDYVDRGYYSVETVTLLVTLKVRFPHRICILRGNHESRQITQVYGFYDECLRKYgNASVWKYFTDLFDYLPLTALVDNQIFCLHGGLSPSIDTLD
 |||.||||||| .|.| | || .||. .| || .|||||||| .   |||| |   .| .| ... | ..|. .|. |...| |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

HIRALDRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIME
..  . |  |.|  | . || |.|||    |.  | ||| . ||     .| .   | .. | ||.| .||..   | .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDDALKYSFLQFDPAPR
.|  || |   | |  |
idkklkisinvfrpesr
subfamily_PPP7C_pd Subfamily PPP7C 196-293 3.3e-22 71.7 In-house 237-335 (383) alignment 
Range on Protein: 196-293
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHTNGLTLITRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPA
. |.|||||   .| .  . ||.|  || |... . .  .|.|. |.|.  .|||...||..|.||||| ||     |. | . | ..|.  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas