Gene PPP3C in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP118_AA protein Get Run
NvecP118_AA_60-263 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP3C_pd Subfamily PPP3C 2-453 2.2e-255 840.5 In-house 9-452 (452) alignment 
Range on Protein: 2-453
Range on HMM: 9-452/452.0
PPVNRLTMADVYDSNGKPRADVLKAHFILEGRVEDEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRG
|. ..||...|.|..|||. .||| ||. |||.|.|.|||||......|.||||.|||.|||||.||||||||||.|||||||.||.|.|||||||||||
pkskklteeevfdetgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrG

YFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPA
||||||||||..||. |..|||||||||||||||||||||.||||||||.||||||||||.||||||.|||||||||||||||..|||.|||||||||||
yfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppa

FGPMCDLLWSDPLEDYGNEKTSEHFSHNTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLK
.||.|||||||||||||.|||.|.|..|.|||||||||| |.|||||.|.|||||||||||||||||||||.|||||||||.||||||||||||||||||
sGplcdllWsdPledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlk

YENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILSICTDEELEDGDEDE--EKTEALKRKEIIRSKIRAIGKMARVFTVLREESESIL
||||||||||||.|||||||||||||||||||||||||||||||||.||.|.|||. .|.|  |..|. ||||.||.|||||||.||||.||||||||.|
yennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeeeskeesesekrkevirnkiraigklarvfsvlreesesvl

QLKGLTpTGHLPVGLLSGGKQEVqaalqghdpTHKISGFEEAKGLDRVNERMPP
.||||| ||.|| |.||.||...         ..|.| |||||.||..||..||
llkglt.tgalprgalsegkegl.........eeklssfeeakkldlineklpp
0045823 Metallo-dependent phosphatases 2-452 2.4e-152 500.7 In-house 11-471 (473) alignment 
Range on Protein: 2-452
Range on HMM: 11-471/473.0
PPVNRLTMADVYDSNGKPRADVLKAHFILEGRVEDEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRG
|.. .||.. ... .|..  |.|. |.. ||... |..||.... . ||.||...||....|.|.||||||..|| .|.|  | |  .|..||||.||||
pvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrG

YFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPA
..|.|....|. ||..| .  ||||||||.|.|. .. |. |.  ||.| .|....| ...|||||. ....|.|||||||....||......|. |.| 
pdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipd

FGPMCDLLWSDPLEDYGNEKTSEHFSHNTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLK
.|...||||||| || |.... ..| .|..||..|.....|..|||..|.|  |.|.|.... ||..... ...|....||.||||||.....|.||||.
dgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlv

YENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILSICTDEELEDGDEDEEKTEALKRKEIIRSKIRAIGKMARVFTVLREESESILQL
.........||..||||..||.|.|||..||||..||.||.|...|.|..|.||.. ..  ...   ...|..|.||.|.||..|||.||||||||.|.|
idedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededilglllleallellrnkilalgkllrvfsvlreesesvlll

KGLTPTGHLPVGLLSGGKQEVQAALQ----------GHDPTHKISGFEEAKGLDRVNERMP
|||||.|.||.|||. ||. .. .|.           ..|....  .||.| |...|||..
kgltpsgllplgllllgkelllesleealkldlineklppsllllsleeekslelinerle
0049330 Metallo-dependent phosphatases 14-321 1.1e-94 310.1 In-house 10-305 (309) alignment 
Range on Protein: 14-321
Range on HMM: 10-305/309.0
DSNGKPRADVLKAHFILEGRVEDEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWT
..  ..  |.|. ... ..... |..|....  . ||..|...||....|.|.||||||..|| .|.|  | |  .|..||||.||||..|.|..|.|. 
lelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevllllla

LKCLYTNTLFLLRGNHECRHLTEYFTFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDP
||.|| .  ||||||||.|.|. .. |. |.. ||.. ....... ...|||||. ....|||||||||....||....|.|. |.|..|..||||||||
lkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdp

LEDYGNektsehFSHNTvRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQF
|... .      | .|. ||..... . |...||. |.|  |||.|.|.. ||... . .      |||.||||||.....|..|||..... |.....|
lpireg......fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisfllf

NCSPHPYWL
...|....|
epvplllll
0053225 Metallo-dependent phosphatases 21-313 2.2e-87 286.2 In-house 9-289 (293) alignment 
Range on Protein: 21-313
Range on HMM: 9-289/293.0
ADVLKAHFILEGRVEDEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTN
 |.|. ...|  ..  |..|....  . ||.||...||....|.|.|||||...|| .|.|  | | ..|..||||.||||..|.|....|. ||.|| .
ldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypd

TLFLLRGNHECRHLTEYFTFKTECKIKY-SEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLEDYGN
  .|||||||...|. .. |. |.. || .....|.... ...|||||| ....|.|||||||....||......|. ..| .|...||||||| . .| 
nvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsgw

EKTSehfshntvRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKsqatgfPSLITIFSAPNYLDVYNNKAAVLKYENN-VMNIRQFN
 .          ||..... . |...||..|.|  |||.|.... ||... .      ..|.|.|||||||....|..|||..... |... .|.
lpsy........rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvwgfklfa
subfamily_PPP5C_pd Subfamily PPP5C 28-320 1e-80 264.1 In-house 28-314 (322) alignment 
Range on Protein: 28-320
Range on HMM: 28-314/322.0
FILEGRVEDEVALKIINDGTAILRKEKTMLEVDAP----ITVCGDIHGQFYDLVKLFEVGGSPATT-RYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTL
|  . ...  .||||. . ...|.|. ...|.. .    .|||||||||||||. .||. |.|...  ||| ||.|||| ||.|..| |...| || | .
fkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhf

FLLRGNHECRHLTEYFTFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLS-PEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLEDYGNEK
|| |||||  .. . . |. |.| ||.|.|.|   |.|. |||| ..|...| |||||   .  ||||..|.||...||  | ...|||||| |  |  .
flsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrsp

TSehfshntvRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKY--ENNVMNIRQFNCSPHPY
..        || .  .    | .||..|||  |||.|| .. ||.. .. .      |||.|||||| |  .||.|...   ... .....|.  .|| 
sk........rGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfktfeavehpd

W
 
v
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 34-307 7.1e-75 244.8 In-house 24-285 (298) alignment 
Range on Protein: 34-307
Range on HMM: 24-285/298.0
VEDEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRH
...|   |.|.  . |..| |...||||||.||||||||. ||..||. .| | .. ||||||||||| ...| .. | . |  | | .||||||||| .
ikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhecea

LTEYFTFKTECKIKY-SEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPledygnEKTSEHFSHNtVR
. . . |. ||| .| | ..| .  . |. |||.||. .. ||.|||||.....||....| | ....      ||||.||      |.. . ...|  |
inrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadp......enavkgwaen.sr

GCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
| |. .   .  ..|.. ..  ..|||     || .. . .      |.||||||.|.. ..| |||.| .....
GvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 34-304 1.3e-65 214.1 In-house 10-270 (287) alignment 
Range on Protein: 34-304
Range on HMM: 10-270/287.0
VEDEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRH
..|.  |....    ||.  ...|||.||||..||||||. ||...|.  | .. ..|||||||||||  |.| .|.|..|| .|.. . |||||||...
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

LTEYFTFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAF--GPMCDLLWSDPledygnEKTSEHFSHNTV
. . . || | | |..| .|    . |. ||| | .... ||.|||.||....||..| | . . | |   | . ||||.||      || .. |  | .
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadp......ekdaktfelnki

RGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYEN
|. |  .      ..|.. ..  |.|||| .. || .. . .      |.|.|||| |     | .||.. ..
raisvvfGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvvsk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 34-304 2e-60 197.6 In-house 23-283 (297) alignment 
Range on Protein: 34-304
Range on HMM: 23-283/297.0
VEDEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRH
. .|  ||...    .....|.|.||.||| ||||||||| ||..||  || | |. ||||||||||| |||| .. | . |  .   ||||||||||  
iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecef

LTEYFTFKTECKIKYS-EAVYDACMESFDCLPLAALMNQQFLCVHGGLSP---EIHTLDDVKKLDRFKEPpAFGPMCDLLWSDPLEDYgnektSEHFSHN
. . . |  ||. .|    .| |  . |. |||. |. .. ||.||||||   .  ||| ..|..| .|    . ..||||.||.        |  .  .
vnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisgl.....sgfmenq

TVRGCSyfYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYEN
   ||   .   |  .   . .|  . |||.  . || ..   .      |.|||||| |   ..| ||..  ..
rgagcg..fgrdavlklcsefkldlvcrahqvvqdgyeffagrk......lvtifsaphycgqfdncaafmscde
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 34-302 2.7e-55 180.4 In-house 16-275 (290) alignment 
Range on Protein: 34-302
Range on HMM: 16-275/290.0
VEDEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRH
 .|.  |.|..    ||.   ..||| |||.. ||||||. .|.. |.  | |   ..||||||||||  |.|  |.|. .| .|.... |||||||.|.
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

LTEYFTFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPP--AFGPMCDLLWSDPLEDygnekTSEHFSHNTV
.   . || |   | .  ..    . |. |.| | .... ||.|||.|..|.. . .| | . . |     | . ||||.|| .|      .. .. |  
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrd.....kddtialnkq

RGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKY
|. |  .   .  ..|..  |  |.|||| .. |. .  . .      |.|.|||| |     |  |... 
raisvvfgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatv
PPP_1 36-301 3.6e-105 344.0 In-house 3-263 (264) alignment 
Range on Protein: 36-301
Range on HMM: 3-263/264.0
DEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLT
 |.. ....  . .|.||...|||...|||||||||||.||.|||.|||....|.|||||||||||..|.|..|.|..||  | ..|||||||||.|..|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

EYFTFKTECK-IKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLEDYGNEKTSEHFSHNTVRGC
....||.|..  |||. .|......||.||||||.....|.||||||||...||...|..|..| |. |..||||..|  ... ..|..|.. .|..||.
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGa

SYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLK
.|.... .|..|||.||| .||||||....||....|..      ..|||||.|| .. .|..|..|
gylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrk......vvtifsasnyyeegsnrgayvk
PP2Ac_SM00156 36-307 3.7e-104 340.5 In-house 3-261 (271) alignment 
Range on Protein: 36-307
Range on HMM: 3-261/271.0
DEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLT
.| .|.....  .||..||...||.||.||.||||||..||..|.| .| |....|.|||||||||..|||..|.|..|| || ....|||||||.....
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

EYFTFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPledygnEKTSEHFSHNTvRGCS
....|. |.|.||.. .|. ..| |..||||||.....||.|||||||...|||..||.|.||.|  |...|||||||      |.. ..|.... ||.|
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp......eqkekgfqpsk.rgls

YFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqatgfpSLITIFSAPNYLDVYNNKAAVLKYENNVM
....  |..|||..|||  ||||||..| ||... ..      .|.||||||||.| ..|||||||.|.|..
vvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
PPP_3 36-307 2e-95 311.8 In-house 4-263 (271) alignment 
Range on Protein: 36-307
Range on HMM: 4-263/271.0
DEVALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLT
 ... ....  . || ||....|..||.|||||||||..||..||..||....|.|||||||||||..|.|..|.|..||..| ....|||||||.|...
enelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqin

EYFTFKTECK-IKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLedygnekTSEHFSHNTVRGC
....||.|..  |... ||....| |..||||||.....|.|||||||.|..||..|||.|..| |  |...|||.|..        ..|.. .|..||.
kvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdp.......ekeeglenskrGa

SYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKsqatgfPSLITIFSAPNYLDVYNNKAAVLKYENNVM
.....  .|.|||..|.|  ||||||....||.....       ...|.||||||.. ..|..|.|| |.. .
gllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
subfamily_PPG1_pd Subfamily PPG1 37-305 1.1e-71 234.6 In-house 16-285 (300) alignment 
Range on Protein: 37-305
Range on HMM: 16-285/300.0
EVALKIINDG-TAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLT
||..| . |    .| ||  . |. .|.|| ||.||||||....|..||    | |||||||||||..|.| .  | .||  |   . ||||||| | .|
evtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqit

EYFTFKTECKIKY--SEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLEDYG-----NEKTSEHFSh
. . | |||  ||     |..   | || | |||.....  ||||||||.. ..|..| ||||.| |  | ..||||||| |.        ..  .||  
qvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfv.

NTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENN
.. ||. | |    . .||.||..  |||||.    ||...  ..      | |..|||||     |||..|. ...
vsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnk......lstvwsapnycyrcgnkasilelyek
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 39-306 3.4e-64 209.8 In-house 13-267 (281) alignment 
Range on Protein: 39-306
Range on HMM: 13-267/281.0
ALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYF
  ..|    ||. .||.. |.|.||.| ||.|.|| || .|||. | .. ....|||||||||  |.|... |.|||  | . ..|||||||  ..   .
ienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiy

TFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPledygNEKTSEHFshNTVRGCSYFY
 |  ||. || | ..    . |. ||..||.... ||.|||||||. .||....  .  ...  | . ||||.||     ..|. | .  ...|| |. .
gfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadp.....dnkveewk..assrGssftf

SYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
      .  .. ..  |||||    .||..    .      |||.||.||| . |.| ||||| ....
GknvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdetl
subfamily_PPZ_pd Subfamily PPZ 39-304 1.3e-59 195.2 In-house 30-282 (300) alignment 
Range on Protein: 39-304
Range on HMM: 30-282/300.0
ALKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYF
 |.|      ..  . ..||.  .. . ||.|||. ||..||   | | .. |||||||||||  |.| .| |.  |  | . .|||||||||  .|  .
ilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvy

TFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLeDYGNEktsehFSHNtVRGCSYFY
 |  ||| .    .. . ...|. |||||..  . .|||||||| . ..|..... |  . | || . |||||||  |  ||     .  |  || || |
gfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdpt.dssne.....wedn.ergvsycy

SYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqatgfpSLITIFSAPNYLDVYNNKAAVLKYEN
   |  .||..  .  . |||   . || ..         ||.|.||||||   ..|  ||.   .
nkvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvse
subfamily_PPP4C_pd Subfamily PPP4C 40-307 6.8e-81 264.6 In-house 22-276 (288) alignment 
Range on Protein: 40-307
Range on HMM: 22-276/288.0
LKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFT
 .. ..   || .|  . .||.|.|||||||||||||..||.|||.   |.||||||.||||..|.|. | | .||. | . . |.|||||.|..|. . 
kalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvyg

FKTECKIKYS-EAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLEDYGnektsehFShNTVRGCSYFY
|  ||  ||   .|.  |.| || |.|||..... .||||||||.|.|||... .|| .| |  ||.|||||||| .  |       ..  . ||  |..
fydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg.......wa.vsprgagylf

SYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
   .. .| ..|..  |.|||.    ||... . .      ..|..|||||     |.||.|...... 
gsdvveqfneandielicrahqlvmegyklhfnek......vltvwsapnycyrcgnvaaileldeeld
subfamily_PPP2C_pd Subfamily PPP2C 40-316 8.6e-80 261.0 In-house 23-287 (290) alignment 
Range on Protein: 40-316
Range on HMM: 23-287/290.0
LKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFT
 ....    ||.||. . || .|.|||||.||||.||..|| .||.   | ||||||||||||.|.|.| .| .||  | . . .|||||| | .|. . 
kelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqitqvyg

FKTECKIKYSE-AVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLEDYGnektsehFShNTVRGCSYFY
|  ||  ||.. .|.    . ||.|||.||...| .|.||||||.|.|||....|||..| |  ||.|||||||| .  |       ..  . ||. | .
fydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrgg.......wg.isprgagytf

SYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQFNCSP
    . .| ..|.|  |.|||.    ||..  . .      ..||||||||     |.||.|. .... ... ||. .|
gkdisekfnktngltliarahqlvmegynwshdrn......vvtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 40-306 4.3e-58 189.9 In-house 12-290 (302) alignment 
Range on Protein: 40-306
Range on HMM: 12-290/302.0
LKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGG-----------SPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGN
|..|.  .. |.||||. |. .|.|. ||||||| |||...               | .. ...|||||||||. ||||.  ...|| || .   |||||
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn

HECRHLTEYFTFKTECKIKYSEAV----YDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAF-GPMCDLLWSDPLEDYGNEKTS
||.. .   ..|. | .......     ..   | |  .|||||. .. ||||||.|| ...|.|.||..|  .  .      |||..|||.  .   .|
hetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavs

--EHFSHNTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
   .. .|.||| |. .   |  .. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
ekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 40-306 6.7e-58 189.2 In-house 13-291 (302) alignment 
Range on Protein: 40-306
Range on HMM: 13-291/302.0
LKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGG-----------SPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGN
|..|.  .. |.||||. |. .|.|. ||||||| |||...               | .. ...|||||||||. ||||.  ...|| || .   |||||
lllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrgn

HECRHLTEYFTFKTECKIKYSEAV----YDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAF-GPMCDLLWSDPLEDYGNEKTS
||.. .   ..|. | .......     ..   | |  .|||||. .. ||||||.|| ...|.|.||..|  .  .      |||..|||.  .   .|
hetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvqllaavs

--EHFSHNTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
   .. .|.||| |. .   |  .. .. ||  |.|||    .|.... . .      |.||||||.|..  .|| |||| . | 
ekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 40-312 1.2e-54 178.7 In-house 12-272 (280) alignment 
Range on Protein: 40-312
Range on HMM: 12-272/280.0
LKIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFT
. ||    ||. .|  . | .||| | |||| |. |. .||.. |     . .|||||||||   || .. |. ||  | . ..|||||||   . . . 
iaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiyg

FKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLEdygneKtSEHFSHnTVRGCSYFYS
|  ||. ||  ...      |. .|...|.... ||.|||||||.  || .... |  ||   | . ||||||| .     |  | . | ..|| ||.. 
fyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptn.....k.gegwfh.sirgisymfg

YPATCEFLQNNNLLSIIRAHEAQDAGYRMYrksqaTGfPSLITIFSAPNYLDVYNNKAAVLKYENNVM-NIRQF
     .  .. ..  |||||.  . || |      .|   |||.|| |||   . | |||.  . |.  ...|.
kgvveqacksleidliirahqvvqdgyemm.....ag.rrlitvfsvpnycaqftnaaavvclnanlqvsfqql
subfamily_PPP7C_pd Subfamily PPP7C 40-197 5.4e-31 100.6 In-house 39-203 (383) alignment 
Range on Protein: 40-197
Range on HMM: 39-203/383.0
LKIINDGTAILRKEKTMLEV----DAPITVCGDIHGQFYDLVKLFEVGGSPATT-RYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHL
|.|. .   .|.. . . .|       .|||||.||.. ||. ..   | |..   |.| ||.||||  |.| .| | .|  .| . ..| |||||   |
llilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhil

TEYFTFKTECKIKY---SEAVYDACMESFDCLPLAALMNQQFLCVHGGLSpEIHTLDDVKKLDRFK
   . |  | . ||   .. .     . |  ||||.|.... | ||||.| ..  |. ..|..| |
nlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersk
subfamily_PPP1C_pd Subfamily PPP1C 41-307 2e-85 279.4 In-house 17-270 (282) alignment 
Range on Protein: 41-307
Range on HMM: 17-270/282.0
KIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTF
....   .|| .. ..||..||....||||||..||..||| .|.|....||||||||||| .|.| .. | ..|. |...|||||||||. ...... |
allkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasinriyGf

KTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPledygnEKTSEHFSHNTvRGCSYFYSY
. ||| .||  .. . .. |.|||||||.... ||||||||||.. |....|. |  | |  | .||||||||      .|... .|.|. || |. .. 
ydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdp......dkevlgwsend.rGvsftfgk

PATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 .  .|||.|.|  |.|||.  ..||... | |      |.|.||||||.. ..|..|||. .....
dvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
subfamily_PPP6C_pd Subfamily PPP6C 41-312 1.5e-73 240.5 In-house 22-281 (290) alignment 
Range on Protein: 41-312
Range on HMM: 22-281/290.0
KIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTF
|. .  . .| .| ..  | .|.|||||||||||||..||  ||.   |.|.||||.|||||.|.| . .| |||  | . . |||||||.|..|. . |
klcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygf

KTECKIKYSEA-VYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPlEDYGNEKTSEhfshntvRGCSYFYS
  ||. || .| ..  |.. || |..||....| |||||||||...|||... ..| .| |  |..|||.|||| ||  . ..|.       ||  |.. 
ydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsp.......rgagylfg

YPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV-MNIRQF
   | ||...|||  |.|||.  . |.. . . .      |.|..|||||     | |..|. |..   . . |
skvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaeereaklf
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 41-305 2.5e-67 219.9 In-house 13-264 (280) alignment 
Range on Protein: 41-305
Range on HMM: 13-264/280.0
KIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTF
..|.  . ||  ..||.|||||..||||.|||. ||..||.  . |  . ||||||||||| . .| .| | . |  | |....||||||. .. . . |
rviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygf

KTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPledyGNEKTSehFSHNtVRGCSYFYSY
| |.| .||.|.|.   | .| |||.||.. . ||.|||||... .|||...| |  ...      ||||.||     |..|   ...|  ||.|. .  
kdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadp....enkvtg..waen.srgvsvifga

PATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENN
    .. .  ..  |.| |.  . || .. . .      |.|.||||.||. ..|.||||. ...
nvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivder
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 41-305 6.1e-49 159.8 In-house 27-281 (307) alignment 
Range on Protein: 41-305
Range on HMM: 27-281/307.0
KIINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTF
..| .  .|.  ||.....| |  | ||.|||| ||...| . | |  | |.| ||||||| .|.||.| |.| |  | . . |||||||  .. . ..|
nviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygf

KTECKI---KYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLEDYGNEKTSEhfshntvRGCSYF
  ||     |  | ..      |. ||..||.  . ||.|||||| .  ||....  .    |  | . |.||.||     . |.|        ||  . 
yeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkass.......rgsgft

YSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSqatgfpSLITIFSAPNYLDVYNNKAAVLKYENN
.      .  .   .  |||||.    || .           |||||||| | ..|.|  .||| .. 
fgtnviddvckrlgveliirahqmcfdgywvlsgr......klitifsapmycnfyknagcvlkvdet
subfamily_PPPLV_pd Subfamily PPPLV 42-307 5.8e-56 182.9 In-house 5-281 (290) alignment 
Range on Protein: 42-307
Range on HMM: 5-281/290.0
IINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLV----KLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEY
. .    || .|. .||...|. | ||.||.. ||.    .|. .|   . . .|||||||||| ||.| . || .|| ||   ..||||||| . ..| 
lcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqes

FTFKTECKIKYS---EAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKK----LDRFKEPPAFGPMC-DLLWSDPLEDY-----GNEKTSE
...|.|.. |.    | |..| .. || ||||| .... .|||.|.   |.|   .      |.|.|..    |.  |.||||| ||      |.  ..|
ieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlne

HFSHNTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
 | .|  || .. .|  |   ||..|||  ..||||....|.|. .|..      |.|.||. .|    |. | .|  .... 
GfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgr......lltvfsssrycGssneaalilvdkkklr
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 42-306 6.2e-56 182.9 In-house 11-264 (284) alignment 
Range on Protein: 42-306
Range on HMM: 11-264/284.0
IINDGTAILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFK
.. .  .|. |.  ..||..|| .|||||||| ||..||.  | |  . |||||||||||   .| .| |.. | .. | .|.|||||||  . . . | 
llfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfy

TECKIKYSE-AVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDR-FKEPPAFGPMCDLLWSDPLEdYgnEKTsehFSHNtVRGCSYFYS
 ||. .| . .|| .    |  .||.||. |. ||.|||.|  .. . ... . | | .|       |.||||| . .  .|    .  |  || || . 
eecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptn.f..qkg...wnpn.srgvsyvfg

YPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNV
  |  ..|.  ..  ..|||.  . || .. . .      |.|||||| |   ..| |||.  ..|.
sdalrklldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 48-307 4.9e-62 202.8 In-house 38-285 (299) alignment 
Range on Protein: 48-307
Range on HMM: 38-285/299.0
AILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECKIK
 .. .. ..|||.||| ||||||||. ||...|.. | |  . .||||||||||   .| .  |   |  | . .|.|||||||  .   . |  ||. .
svfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygfyeecnkr

YS-EAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPledygnEKTSEHFSHNtVRGCSYFYSYPATCEF
|    .. .  ..|. .||. |.. . ||.||||||...||| ...| | ..||.     ||||.||      ...   .  | ||| || .      . 
ykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadp......dqsvkdwlan.vrgvsyvfgqdvvadv

LQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
... ..  . |||.  . || .. . .      |.|||||| |   ..| ||..| ..|..
isrldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlv
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 49-307 2.2e-64 210.6 In-house 23-274 (284) alignment 
Range on Protein: 49-307
Range on HMM: 23-274/284.0
ILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSP------ATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKT
.. |||  ||..||....||||||| ||. |... | |        ..||||||||||| |||| .. |...| |. . .|||||||| | .   . | .
lfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyl

ECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLWSDPLEDYgnektsEHFsHNTVRGCSYFYSYPA
||| .||||.|.|   .| ..||.|..... .|.|||.| ..  |....||.|  . |  | ..|| |.|| ..       |.. ... ||.   .   |
eckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaev......egy.kesprgagkvfgaka

TCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYENNVM
  |||.. .|  ..|||.    || ..   .      |.|||||| |   ..| ||||. .....
vkeflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 49-88 8.3e-11 34.6 In-house 24-63 (317) alignment 
Range on Protein: 49-88
Range on HMM: 24-63/317.0
ILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPAT
.. ||. .||..||.|..||||||| ||. |... | | .
lfwkeplkleleapvtivGdihGqfedllalldlnGwpls
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 49-87 8.7e-07 21.3 In-house 26-64 (339) alignment 
Range on Protein: 49-87
Range on HMM: 26-64/339.0
ILRKEKTMLEVDAPITVCGDIHGQFYDLVKLFEVGGSPA
..  |  .|...||| | ||||||| ||. .... | | 
liwsepiflkleapicvmgdihgqfddllamldmngwpl
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 56-302 1.9e-48 158.4 In-house 2-242 (263) alignment 
Range on Protein: 56-302
Range on HMM: 2-242/263.0
MLEVDAPITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECKIKYS-----E
.||..||| .||| |||. ||...|.  |. . |.||||||||||| .|.| .. |..||      ..||||||| . . . . |..| | ..      |
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

AVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPM-CDLLWSDPledygnEKTSEHFSHNTVRGCSYFYSYPATCEFLQN
.||.   . |  .||.|..... ||.|||.|| ...|||.. .    |     |. |||||.||      || .. |  | .|  |  .      .. . 
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadp......ekdakgfepnkiraisnvfgkkevddlckr

NNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKY
 ..  |.|||.  . || ..   .      |||.|||  |     | |||.  
ldidlivrahqvveygyaffadrr......litvfsasryqielcnyaavvvv
Metallophos Calcineurin-like phosphoesterase 62-262 1.4e-41 135.9 Pfam-A 2-199 (200) alignment 
Range on Protein: 62-262
Range on HMM: 2-199/200.0
PITVCGDIHGQFYDL----VKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYL--WTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECK----------
.|.|.||.||...||     .|.......  . .|||||.||||  |.|.  .|  . || |. . .||||||||........ |. |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------IKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLDDVkkldrfkeppafgpmcdllwsdpledygnek
                         ..   ..... | |..|||.|| ....|..||.||..  . ||                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

tsehfshntvrgCSYFYSYPATCEFLQNNNLLSIIRAHEAQ
            .|. ....|....|.....  ..|.|. .
............gselfgpdalekllekygvdlvlrGHtHk
PPP_4 63-262 1.8e-72 236.5 In-house 1-197 (197) alignment 
Range on Protein: 63-262
Range on HMM: 1-197/197.0
ITVCGDIHGQFYDL-VKLFEVGGSPA-TTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECKIKYSEAVYDACMESF
.||.||||||..|| .||...|| |. ...|.|||||||||..|.|..|.|. ||. | ....|||||||...|.....||.|.. |... ........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

DCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPP-AFGPMCDL-LWSDPLedygneKTSEHfSHNTVRGCSYFYSYPATCEFLQNNNLLSIIRA
|.||||||.....|.||||||.|...||......|..| |   . ..|| |||||       .. |. ..|.|||....... .|..||..||| .|||.
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr......eaqeg.lansvrGagllFgpdvtekfleknnlkliirs

HEAQ
||..
helk
PPP_2 63-261 8.8e-72 233.9 In-house 1-197 (198) alignment 
Range on Protein: 63-261
Range on HMM: 1-197/198.0
ITVCGDIHGQFYDLVKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECK-IKYSEAVYDACMESFD
.|||||.|||..||..||..|.......|||||||||||..|.|..|.|..||. | ....|||||||.........||.|..  |....||....| |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

CLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPPAFGPMCDLLwsdPLEDYGNEKTSEHFSHNTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEA
.||||||.....|.||||||.||..||..|| .|..| |. |...|||   . |.. ..|..|.. .|..||......  .|.|.|..|.|  ||||||.
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_5_Dcr2 63-261 1.8e-68 223.5 In-house 1-198 (199) alignment 
Range on Protein: 63-261
Range on HMM: 1-198/199.0
ITVCGDIHGQFYDL-VKLFEVGGSPA-TTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECKIK-YSEAVYDACMES
.|||||.|||..|| ..||. || |. ...|.|||||||||..|.|..|.|. ||..| ....|||||||...|.|...|..|.. | ... .|... ..
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDCLPLAALMNQQFLCVHGGLSPEIHTLDDVKKLDRFKEPP-AFGPMCDL-LWSDPLedygneKTSEHFSHNTVRGCSYFYSYPATCEFLQNNNLLSIIR
||.||||||.....|.|||||||||.......|..|..| |   | ..|| |||||       .. |.   |..||....... .|..||..|||  |||
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr......daqegcklnseRGagllfgpdvtekfleknnlkliir

AHEA
.||.
shel
subfamily_YNL217W_pd Subfamily YNL217W 63-183 8.7e-07 21.7 In-house 12-139 (235) alignment 
Range on Protein: 63-183
Range on HMM: 12-139/235.0
ITVCGDIHGQFYDLVKLFE--VGGSPATTRYLFLGDYVDRGYFSIECVLYLwtlkclYTNTLFLLRGNHECRHLTEYFTFKTE---------CKIKYS-E
. | ||.|| . .|..|..  .||       ...|| ...|  |.| | |.        .    ..||||   | .|   | .          |...   
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

AVYDACMESFDCLPLA-ALMNQQFLCVHGGLSPE
.. .| ||    |. .  .  .. | ||.||.| 
klskadmeyarelgfsldipsdellvvhaGlvpg
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 88-306 6.5e-55 179.5 In-house 100-305 (317) alignment 
Range on Protein: 88-306
Range on HMM: 100-305/317.0
TTRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTL
  .||||||||||| |||| |. | .|| || . .|||||||| | .   . | .|.| .||.|.|.|    | .|||.|..|.. ||.|||.| |.  |
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DDVKKLDRFKEPPAFGPMCDLLWSDPledygnEKTSEHFsHNTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAP
. ..||.|  . |  | ..|| |.||      ... ... ... || .  .  .|  |||.. .|  ..|||.    || ..   .      |.||||||
kqldklkrpldipdvGvladltwadp......daevkgy.kesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvtifsap

NYLDVYNNKAAVLKYENNV
.|    .| ||||. ....
sycGqldniaavlsvdkkl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 89-305 5e-43 140.5 In-house 120-323 (339) alignment 
Range on Protein: 89-305
Range on HMM: 120-323/339.0
TRYLFLGDYVDRGYFSIECVLYLWTLKCLYTNTLFLLRGNHECRHLTEYFTFKTECKIKYSEAVYDACMESFDCLPLAALMNQQFLCVHGGLSPEIHTLD
 |||||||||||| ||.| |. | .||  | . ..||||||| | .   . |  | . .|   .|..  . |. .|..|..|.  .|.|||.|  . ...
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

DVKKLDRFKEPPAFGPMCDLLWSDPledygneKTSEHFSHNTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPN
..  . |  | |  | . || |.||         .|.  . . ||.|. .  ||   ||.. .|  .|| |.  . || ..   .      |.|||||||
qfsvfkrpleipdvgvltdltwadp.......dptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvtifsapn

YLDVYNNKAAVLKYENN
|    .| |||.  ...
ycgqndntaavfsidkk
subfamily_PPP7C_pd Subfamily PPP7C 205-307 5.5e-14 44.7 In-house 237-326 (383) alignment 
Range on Protein: 205-307
Range on HMM: 237-326/383.0
MCDLLWSDPLEDYGNektsehfSHNTVRGCSYFYSYPATCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQatgfpsLITIFSAPNYLDVYNNKAAVLKYEN
. |.||||| .. |          ||.||   ..    | ..||. ||  .||.|| .  || .  ...      ..||||| || ..  |. | .|  .
vldilwsdpkakeGc.......kpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkk......vltifsasnyyeeGsnrGayvklgk

NVM
...
dlt