Gene PPP5C in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP120_AA protein Get Run
NvecP120_AA_160-479 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
TPR_11 TPR repeat 20-85 2.1e-18 55.4 Pfam-A 2-68 (69) alignment 
Range on Protein: 20-85
Range on HMM: 2-68/69.0
EAEDLKLKANGYFKEGNYNSAITFYTQAIELKADVPAYYGNRSFCYLKTE-YYGLALADANKAIQLD
.|| || ..| .||||.|  || .|..|.||  . . .| |.. .|||    |  ||.|..||..||
nAealkelGnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleld
TPR_2 Tetratricopeptide repeat 22-50 4.5e-07 19.2 Pfam-A 2-30 (34) alignment 
Range on Protein: 22-50
Range on HMM: 2-30/34.0
EDLKLKANGYFKEGNYNSAITFYTQAIEL
| |   .. |.| |.|. |. .. .|.||
ealynlGlayyklgdyeeAleafekAlel
TPR_1 Tetratricopeptide repeat 24-51 8e-08 21.3 Pfam-A 4-31 (34) alignment 
Range on Protein: 24-51
Range on HMM: 4-31/34.0
LKLKANGYFKEGNYNSAITFYTQAIELK
|. ..| |.| |.|. |. .| .|.|| 
lynlGnaylklgkydeAleyyekALeln
TPR_12 Tetratricopeptide repeat 27-87 3.1e-07 19.7 Pfam-A 11-78 (78) alignment 
Range on Protein: 27-87
Range on HMM: 11-78/78.0
KANGYFKEGNYNSAITFYTQAIELK-------ADVPAYYGNRSFCYLKTEYYGLALADANKAIQLDRK
 |. ....|.| .|...| .|.||        .|.  .. | . .||. . |  ||.  .||.....|
lalvlrrlgdydeAlelyekalellrelgddhpdtaralnnlanlylalgdydeAleylekAleiaek
TPR_7 Tetratricopeptide repeat 28-53 7.5e-06 14.7 Pfam-A 6-31 (36) alignment 
Range on Protein: 28-53
Range on HMM: 6-31/36.0
ANGYFKEGNYNSAITFYTQAIELKAD
|. |.. |.|  ||..|..|..|. |
arlysrlgdyekAielyeraLaltkd
TPR_11 TPR repeat 73-120 1.6e-09 26.9 Pfam-A 21-69 (69) alignment 
Range on Protein: 73-120
Range on HMM: 21-69/69.0
LALADANKAIQLDRKYIKGYYRRATANMALG-KFKLSLKDYEMVVKFHP
 |..  .||..|| .. . ||..| | . || ...  |.|||....  |
eAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_1 Tetratricopeptide repeat 90-122 2.5e-07 19.8 Pfam-A 2-34 (34) alignment 
Range on Protein: 90-122
Range on HMM: 2-34/34.0
KGYYRRATANMALGKFKLSLKDYEMVVKFHPSD
| .|... | . |||..  |..|| ...  |..
kalynlGnaylklgkydeAleyyekALelnPnn
PPP5 PPP5 TPR repeat region 128-220 1.1e-34 108.8 Pfam-A 1-95 (95) alignment 
Range on Protein: 128-220
Range on HMM: 1-95/95.0
KYTECKKIVQRQAFEKAIAAE--EKLVSDSIDVDAIVVENDYDGPRIDENGITSEFIKEMMDRFKDQKKIHKKYAYMILKQAKVMFEKMPSLIEI
|..||.|.|...||||||. .  .. |..|||.. | .|.||||||.... .| ||.||....||.|||.|||..| || . | ...|.|||.||
KlkeCeklvkkiaFekAIevdeekrsvaesidiesieieddYdgprledekvtlefvkelleefkkqkklhkkfvyqilldvkellkklpslvei
0045823 Metallo-dependent phosphatases 161-479 4.9e-106 348.1 In-house 10-338 (473) alignment 
Range on Protein: 161-479
Range on HMM: 10-338/473.0
IVVENDYDGPRIDENgITSEFIKEMMDRFKDQKKIHKKYAYMILKQAKVMFEKMPSLIEITIpkgkTFTVCGDIHGQFYDLLNIFKLNGLPSKeNPYLFN
| |   ...|..  . ..  .........| .......... .|..|| .. |.|.|.|..      ..|.||||||..|||......|.|.. . ..|.
ipvlrlltlpllfil.lglldldlliehlkkegllpeedllklldeakeilkkepnllelsm....rivviGDiHGqlddLlrllekigfppe.drlvfl

GDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYP----YLFTEVYNWLPLCHLINKKVLVMHGGLFSTDgIKLDDLRTI
||.||||..| ||.  |...|..||...|. |||||.  .|..||| .|. .||       | |. ..|||...|..|.|..||||..     ||..|.|
GDlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqirei

SRNKQPPSEGPMCDLLWSDPQPQPG--------RSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGK------CITIFSAPNYCDQM
 |  ..|..|...|||||||... |        .  |.||.| .||||..|.|.|.||| ||.|.|.. |||||...|||      .||.|||||||...
erpleipddgllldllwsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrg

GNKGAFITMGDDLkPKFTTYEAVPHPDVKPMAYSNSL
||..|......|| ..|......||| ..|..... |
gnlaAvlvidedl.isfiqfdpsphplilplfldvfl
subfamily_PPP5C_pd Subfamily PPP5C 163-478 4.9e-182 597.1 In-house 2-322 (322) alignment 
Range on Protein: 163-478
Range on HMM: 2-322/322.0
VENDYDGPRIDENGITSEFIKEMMDRFKDQKKIHKKYAYMILKQAKVMFEKMPSLIEITIPKGKTFTVCGDIHGQFYDLLNIFKLNGLPSKENPYLFNGD
||..||||...|. ||.||.||....||.|||.|||||..||..|| ...|.|||.||||...|..|||||||||||||||||.||||||.|||||||||
vedsydgpkleeekitkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGd

FVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYPY----LFTEVYNWLPLCHLINKKVLVMHGGLFSTDGIKLDDLRTISR
||||||||.|||.||..||||||.|||.|||||||..||..|||.|||||||      |||||.|||||.|.||.||||.||||||.||..|||||.|.|
fvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidr

NKQPPSEGPMCDLLWSDPQPQPGRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITM-GDDLKP
|.|||.|| ...|||||||...|||.||||||.|||||.|.||.|.|.||||||||||| |||||.||||.||.||||||||||||||||||. |||||.
naqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlkl

KFTTYEAVPHPDVKPMAYSNS
||.|.|||.|||||||||.||
kfktfeavehpdvkpmayans
subfamily_PPP7C_pd Subfamily PPP7C 163-360 2e-62 204.1 In-house 2-203 (383) alignment 
Range on Protein: 163-360
Range on HMM: 2-203/383.0
VENDYDGPRIDeNGITSEFIKEMMDRFKDQKKIHKKYAYMILKQAKVMFEKMPSLIEITIPKGKTFTVCGDIHGQFYDLLNIFKLNGLPSKENPYLFNGD
||..|.|||..   .| . ...... || .|..| ||  .||..|| .....|.. ...    |  |||||.||.. ||| |.  |||||.||||.||||
vedsytgprls.lpltkdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGd

FVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYP-------YLFTEVYNWLPLCHLINKKVLVMHGGLfsTDGIKLDDLRT
|||||. | |... |... |.||..... ||||| . .|  |||  ||. ||.        |. .|. ||||. ||..|.|..|||.  .|  .|. |  
fvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGi..sdktdlelldk

ISRNK
|.|.|
iersk
0049330 Metallo-dependent phosphatases 175-471 6.4e-94 307.5 In-house 10-305 (309) alignment 
Range on Protein: 175-471
Range on HMM: 10-305/309.0
NGITSEFIKEMMDRFKDQKKIHKKYAYMILKQAKVMFEKMPSLIEITipkgKTFTVCGDIHGQFYDLLNIFKLNGLPSKeNPYLFNGDFVDRGSFSCEVI
  .. ........... .|..........| .|| .. ..|.|.|..      ..|.||||||..|||......|.|.  . ..|.||.||||..|.||.
lelilslldllielllklkllseeellllllkakeilksepnllels....mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdslevl

FTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYP----YLFTEVYNWLPLCHLINKKVLVMHGGLFSTDgIKLDDLRTISRNKQPPSEGPMCD
 .|...|||||...|. |||||.  .|..||| .|...||       |......|||...|..|.|..||||..     ||..| . |  ..| .|..||
llllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirelerpleipldgllcd

LLWSDPQ-PQPGRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYEAVPHPD
||||||.   .|   ..||.|. ||....|.|.| |||.||||.|.. ..||....|||.||.|||||||...||.||......||.. |...|.||.. 
llwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvplll

VK
..
ll
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 176-462 3.7e-80 262.1 In-house 5-291 (298) alignment 
Range on Protein: 176-462
Range on HMM: 5-291/298.0
GITSEFIKEMMDRFKDQKKIHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIF
 . .|...  .   |  |.|...    ....|| .|.| .||.|.  |     .||||||||. ||| .|. .| | ..| ||| ||.||||... ||| 
ellievlsvslsekkltkvikeedveklielakkifkkqkslvevdap....ikvcGdihGqysdllrlfdkagfppdan.ylflGdyvdrGrqnleviv

TLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYP-----YLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCD
 |...|. ||..||. ||||| ...|..|||  |.| .|        | .|.|.|||. || ...| ||||| |    .||.||...| .....|    |
lllaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGl.skklksldqlrelkrpfdskeeslaid

LLWSDPQP-QPGRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTY
|||.||.  . | ....|||...|| |  ......  ..|..|.| |  .||| . . | .||||||.||.|. |  |.... ..|.  |. .
llwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevl
0053225 Metallo-dependent phosphatases 177-466 1.9e-87 286.4 In-house 4-292 (293) alignment 
Range on Protein: 177-466
Range on HMM: 4-292/293.0
ITSEFIKEMMDRFKDQKKIHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKeNPYLFNGDFVDRGSFSCEVIFT
..  ... ...... .|..........| .|| .. |.|.|.|.. .    ..|.|||||...|||..... |.|.  . ..|.||.||||..| ||.  
lilllldllielllllkllseeelllllleakeilkkepnllelsmr....iyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlel

LFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKY-----PYLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDL
|...|||||..... |||||.  .|..||| .|...||     .  .......|||..||..|.|..|||| | | . ||..| | |  ..| ||...||
llalkllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGl.spdlslldqireinrplriplegllldl

LWSDPQPQPGRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYEAVP
|||||.   |   |.||.|. ||......|.| |||.||||.|.| |.||....|||..|.||||||....||.||.......|...|.....|.
lwsdpdlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP2C_pd Subfamily PPP2C 183-467 9.1e-78 254.4 In-house 5-288 (290) alignment 
Range on Protein: 183-467
Range on HMM: 5-288/290.0
KEMMDRFKDQKKIHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGlPSKENPYLFNGDFVDRGSFSCEVIFTLFSFKL
.......|. |.....    . ..|| ...|   . |. .|     |||||.||||.|||..||. |  | .  ||| ||.|||| .| | .  | ..|.
dklieklkeckqleesevkelcekakeilskesnvqevkcp....vtvcgdvhgqfhdllelfkigg.kspdtnylflgdyvdrgyysvetvtllvalkv

LYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYP-----YLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQ
 |.|   . ||||||  . |.||| .|.  ||       .||.....|||. |........|||| |     ||..|.. | .. | |||.||||||||.
rykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhggl.spsidtldkiraldrlqevphegplcdllwsdpd

PQPGRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYEAVPH
 . | . |.|| | .|| ||.||| | |||.||.|.|..  |||...|| . .||||||||| . ||..| . . |.|| .| .... |.
drggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
subfamily_PPP3C_pd Subfamily PPP3C 183-471 1.3e-74 244.6 In-house 29-328 (452) alignment 
Range on Protein: 183-471
Range on HMM: 29-328/452.0
KEMMDRFKDQKKIHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKeNPYLFNGDFVDRGSFSCEVIFTLFSFKL
. . . |. . ..... |  |...|  ...| ..|.|.  |     ||.|||||||||||..|...| |..   ||| ||.||||.||.|... |.. |.
evlkehflkegrleeeaalkiieeaakllkkektlleveaP....itviGdihGqfydllklfevgGdPas.tkylflGdyvdrGyfsiecvlylyalki

LYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYPY----LFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQP
 ||...|. |||||.  . . . |  |.| ||       ..| .. |||  |.|.. | .|||| |..  .|||.... | |.||. ||.||||||||  
aypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGl.speikslddikkldrfkeppasGplcdllWsdPle

QPGRSA--------SKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHD------GKCITIFSAPNYCDQMGNKGAFITMGDDlKPKFTTYEA
. | ..        | ||  . ..   . .| ..| |  |||.||.. .||.. ..         ||.||||||.|   ||.| . . .. . .   ...
dygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyenn.vmnirqfns

VPHPDVK
.|||   
sphpywl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 188-462 2.6e-61 200.2 In-house 9-286 (290) alignment 
Range on Protein: 188-462
Range on HMM: 9-286/290.0
RFKDQKKIHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEH
..   . .  |  . ||.... ..| .|.|.|.  |     .. ||||||. .||. |.  | | | . .|| ||.||||. | ||   || .|..|...
kygvldafsdkdileilekieeileplpalleveap....ivivgdihgqldallryfdavgyppkvk.flflgdyvdrgakslevslllfcykiryskk

FFMSRGNHESSSMNQMYGFDGEVKAKY----PYLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQP--PSEGPMCDLLWSDPQP---
  . |||||   .|..|||  |.  |        . .|.. |.||  ...|.| ||||. | .    . |... . . |    || . ||||.||.    
vhllrgnhevrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggi.sqkiesweslkalkkprvpltcdeglqvdllwadptrdkd

QPGRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTY
.  .   .|.. . || .  ....|  .|.||.|.|||| ||.. . | |..|.|||| |. .  | || .|. . |. .... 
dtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvl
subfamily_PPP4C_pd Subfamily PPP4C 190-466 9.8e-76 247.7 In-house 11-286 (288) alignment 
Range on Protein: 190-466
Range on HMM: 11-286/288.0
KDQKKIHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPsKENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFF
.. . |...    . ..|. .. .   . ..  |     ||||||||||||||..||..|   .|. ||| ||||||| .| | .. | ..|. ||..  
rrcelikeeevkalcakareilveesnvqrvdsp....vtvcgdihgqfydllelfkvggdv.petnylflgdfvdrgfysvetfllllalkvrypdrit

MSRGNHESSSMNQMYGFDGEVKAKYPY-----LFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQPQPGRSA
. |||||| .. |.|||  |.  ||       . |||...|.|. .|..|....|||| | .  .||..|.| |... | |||.||||||||. . | ..
lirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhggl.spsistldeirsidrkqevphegplcdllwsdpedaegwav

SKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYEAVP
| || |  || |..|.|...|..|||.|.|..  ||| .. . | .|..|||||| . ||. | . . ..|. .|. .||..
sprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_PPP1C_pd Subfamily PPP1C 191-461 1.4e-83 273.4 In-house 6-275 (282) alignment 
Range on Protein: 191-461
Range on HMM: 6-275/282.0
DQKKIHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFM
 . |....   ..||.|. .. . | |.|.. |     ...||||||..|||..|. .| |...| ||| ||.||||..| |.|  |...|. |||..|.
kevklkeaeieallkkareillsqpilleleaP....vkivgdihGqyadllrlfetsgaPpesn.ylflGdyvdrGkqsletivlllaykikypenlfl

SRGNHESSSMNQMYGFDGEVKAKYPY----LFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQPQ-PGRSAS
 ||||||.|.|..|||  |.| .|       ||.|.|.|||. |...|.|..|||| |..  .|...|.|.|  . |..| .||||||||. .  | |..
lrGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGl.spelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsen

KRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTT
.||| ..||.|. |||...| |.||.|.|.|  .||| . . . .|.|||||||....|.|| ... ..|. .|. 
drGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqi
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 192-462 9.1e-68 221.7 In-house 5-280 (284) alignment 
Range on Protein: 192-462
Range on HMM: 5-280/284.0
QKKIHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLP-----SKENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPE
|| ...|  . .  .|. .| | .  .|| .|     ...||||||| ||| ...||| |     .||. ||| ||.|||| || |||  ||..|||.|.
qkllkekelielcyrarelfwkeklkleieap....vkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpd

HFFMSRGNHESSSMNQMYGFDGEVKAKYPYLFTEVY----NWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQPQP-G
. |. ||||||  .|. |||  | | .|   . |..    | .||| ...||.. ||||. | | ..|..|  ..|  . |  | ..|| |.||. .  |
kvfllrgnhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggi.sedlldlkqldklerpidipdigviadltwadpeaeveg

RSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTY
   |.|| |  ||..  ..|.|   |.|..|.|.|  .||| . | | .|||||| || |. | .| ... ..|   ||. 
ykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvl
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 192-451 1.1e-44 145.8 In-house 3-286 (302) alignment 
Range on Protein: 192-451
Range on HMM: 3-286/302.0
QKKIHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGL----------PSKENPYLFNGDFVDRGSFSCEVIFTLFSFK
.|. .|.  ......   ...|  .|.||. |     |. ||||||| ||. |.. .               .. ..| ||.||||| | | |  .|..|
kkeysksellllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalk

LLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYP--------YLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPM-CDLL
.|||... . |||||. ..|  ||| .|.. ..           | ||. ..||  |. .|.| .|||. |     |.|.. |.|  .  .| ..  |||
vlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdll

WSDPQPQPG----------RSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITM
..||    .              .||. . |     ...||  .|.||.|.| . |||.  . | | .||||||.| ... |||| . .
fadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 192-452 1.3e-44 145.6 In-house 4-288 (302) alignment 
Range on Protein: 192-452
Range on HMM: 4-288/302.0
QKKIHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGL----------PSKENPYLFNGDFVDRGSFSCEVIFTLFSFK
.|. .|.  ......   ...|  .|.||. |     |. ||||||| ||. |.. .               .. ..| ||.||||| | | |  .|..|
kkeysksellllieaviellkkektlaeispP....vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalk

LLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYP--------YLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPM-CDLL
.|||... . |||||. ..|  ||| .|.. ..           | ||. ..||  |. .|.| .|||. |     |.|.. |.|  .  .| ..  |||
vlyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdll

WSDPQPQPG----------RSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMG
..||    .              .||. . |     ...||  .|.||.|.| . |||.  . | | .||||||.| ... |||| . . 
fadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 195-465 1.5e-67 221.0 In-house 24-294 (299) alignment 
Range on Protein: 195-465
Range on HMM: 24-294/299.0
IHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGN
....    . . || .| . .||.|.  |      ||||||||. ||| ||. .|.| . | .|| ||.||||    |.|  |. ||. |||.||| |||
vkeqelqtlcavaksvfasqaslleveap....iivcgdihgqysdllrifdkagfppdvn.flflgdyvdrgrqnlelitlllcfkikyperffmlrgn

HESSSMNQMYGFDGEVKAKYP-----YLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQP-QPGRSASKRG
||  ..|..|||  |.. .|       .| . ....||. ||. ..|.||||| |    .|| || ..| ..||.     ||||.||.    .  |  ||
hecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhggl.spklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrg

VGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYEAV
|   ||.|. .. ..  ...|. |.|.|  .||| . . | .|||||| || |. |  | . . ..|   |. ..  
vsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkpt
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 195-462 3.4e-67 219.4 In-house 10-279 (287) alignment 
Range on Protein: 195-462
Range on HMM: 10-279/287.0
IHKKYAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGN
.  |  . .|.... ..| .|.|.|.. |     |..||||||. |||.||.  | ..| . ||| ||.||||. | ||.. |||.|..||..  . |||
fsdkdilevlekieeileplpalleveap....itivGdihGqlddllrifnavGaapkvq.ylflGdyvdrGakslevslllfslkiaypkkvhllrGn

HESSSMNQMYGFDGEVKAKYP----YLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPS--EGPMCDLLWSDPQPQPG--RSASK
||   .|..|||  |.| |.       | .|.. ||||  ..|..| ||||. | .   ||.|..... ..| .  || . ||||.||. .    .    
hevkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGi.spklksldslkalkkpttplacdeglqvdllwadpekdaktfelnki

RGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTY
|..   ||    ....|  ...||.|.|||. |||. . | ...|.|||| |. .  | || ... . |. .|.. 
raisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvl
PP2Ac_SM00156 196-464 5.6e-103 336.7 In-house 2-269 (271) alignment 
Range on Protein: 196-464
Range on HMM: 2-269/271.0
HKKYAYMILKQAKVMFEKMPSLIEITipkgKTFTVCGDIHGQFYDLLNIFKLNGlPSKENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNH
.|.... .|...| .......|.|..    .  ||.||||||..|||....|.| ...|..|.|.||.||||..|.||| .||..|.||||.... ||||
skeevlelleevkeilkqeknlvevs....apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnH

ESSSMNQMYGFDGEVKAKY----PYLFTEVYNWLPLCHLINKKVLVMHGGLFStDGIKLDDLRTISRNKQPPSEGPMCDLLWSDP-QPQPGRSASKRGVG
||||.|..|||  |||.||       |.|....|||. |...|.|.||||| . .  .|||.| . |.|..| ||...||||||| |...| ..||||..
EsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrgls

IQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYEA
..||.|....|.| | |.||||.|||..||||...|.|..||||||||||...||.|.... ..||... ....
vvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
PPP_3 196-463 6.7e-98 320.0 In-house 3-270 (271) alignment 
Range on Protein: 196-463
Range on HMM: 3-270/271.0
HKKYAYMILKQAKVMFEKMPSLIEITipkgKTFTVCGDIHGQFYDLlNIFKLNGLPSKENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNH
... .. ..|..| ..|| ..|.||.    .  |||||||||..|| .... ||.||.|. |||.||.||||..|.||...|...|..||..... ||||
senelkelvkklkeilekesnlveis....apvtvcGDiHGqldDL.lelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnh

ESSSMNQMYGFDGEVK-----AKYPYLFTEVYNWLPLCHLINKKVLVMHGGLFSTDGiKLDDLRTISRNKQPPSEGPMCDL-LWSDPQPQPGRSASKRGV
||...|..|||  ||.     .|    ..||...|||..||..||||.||||...   .||......|... |.||...|| |.|||. . | . ||||.
EsrqinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsik.sldqikklerkievpeegklldlllssdpekeeglenskrGa

GIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYE
|. ||||.||.|...| |.||||.||.|.||||..||||..|.|||||||....|.||.......|...|...|
gllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 199-459 2.9e-63 206.9 In-house 27-289 (297) alignment 
Range on Protein: 199-459
Range on HMM: 27-289/297.0
YAYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESS
    .|  |  .|..  |..|.  |      ||||||||| ||| .|.  | |   | ||| ||.|||| || | |  |...|. .|  .|. |||||  
rvlklldlaldvfkaqksmvevnap....ikvcgdihgqfpdllrlfhrggwpptan.ylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhece

SMNQMYGFDGEVKAKYPY-----LFTEVYNWLPLCHLINKKVLVMHGGLFS--TDGIKLDDLRTISRNKQpPSEGPMCDLLWSDPQP-QPGRSASKRGVG
 .|..|||  |.. .|        | .|.|||||. || .|.|.|||||    |. . || || | |...   |. ..||||.||     |    .|| |
fvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfmenqrgag

IQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKF
  || |   | | .  |.|. |.|.|  .|||..   | .|||||| || |. |  ||..  . |.  |
cgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsf
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 200-459 6.1e-67 218.7 In-house 11-269 (280) alignment 
Range on Protein: 200-459
Range on HMM: 11-269/280.0
AYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSS
 . .... | ..    ...|.  |     .||||.|||. ||| .|.  ..|  .| ||| ||.||||..  |||  |...|. ||..|.. |||||  |
idrviekckkiltaqatmvevdap....vavcgdlhgqytdllrlfarvsfppdqn.ylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevis

MNQMYGFDGEVKAKYPY----LFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQ-PQPGRSASKRGVGIQFG
.|. |||  ||| .|       | |... |||. |.. ..|.||||| | . . ||||. . |  ... |    ||||.||.  . | ... ||| ..||
inrkygfkdevkrryslalynefqelldslplvalvsgrilcmhggl.sqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifg

PDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKF
 ..  ....   ..||.| |.|  .||| . | | .|.||||.|.... |. | . . . |.  |
anvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsf
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 200-461 8.5e-66 215.0 In-house 13-273 (281) alignment 
Range on Protein: 200-461
Range on HMM: 13-273/281.0
AYMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSS
   ...... .| .  .|.||  |     .| ||.|.|| || ..|.| | ...|  ..| ||.||||  | ||.. ||..|. |... .. ||||| .|
ienvireveaifseekaLveidkP....ivvvGdlhaqfndlkrlfellgrvpeev.lvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

MNQMYGFDGEVKAKYP----YLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQPQP-GRSASKRGVGIQFG
.|..|||  | . ||     .|| . .| ||.  ||.|.||.||||| | . . ||.|| . .  ...  | . ||||.||...  .  || ||..  ||
vnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGl.sPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

PDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTT
 .. .. ||  ..|||||.| |  .||||.   | ||.||.||||..  | .| ... ..|. .. .
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislva
subfamily_PPZ_pd Subfamily PPZ 201-460 1.5e-54 178.5 In-house 31-289 (300) alignment 
Range on Protein: 201-460
Range on HMM: 31-289/300.0
YMILKQAKVMFEKMPSLIEITiPKgktFTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSM
  | ..|. .|   |.|.|.. |      . ||.|||. ||| .|   |.| . | ||| ||.||||  | | |. |. .|. ||| ||. ||||| . .
lqicikarelflaqpallels.ps...vkivgdvhgqyadllrlftkcgfppsan.ylflgdyvdrgkqsletillllcykikypenffllrgnhecanv

NQMYGFDGEVKAK----YPYLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQPQPGR-SASKRGVGIQFGP
 ..|||  |.| .        | . .| |||. ..  |....|||| |     .|..| ..|  . |  | . |||||||   .      .|||   .  
trvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhggl.spvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycynk

DITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFT
   .|| .  |..|. |.| |  .|||.. |   .|.||||||| .. | || ... . |   | 
vainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfe
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 201-253 5e-08 25.5 In-house 15-63 (317) alignment 
Range on Protein: 201-253
Range on HMM: 15-63/317.0
YMILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSK
. .  .|. .| | |  .|. .|     |..||||||| ||| ...||| |  
ielcyrarelfwkeplkleleap....vtivGdihGqfedllalldlnGwpls
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 202-457 6.6e-59 192.6 In-house 10-266 (284) alignment 
Range on Protein: 202-457
Range on HMM: 10-266/284.0
MILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMN
 .| .|  .|.| | |||.  |      .|||||||| ||| .|  ||.| . | ||| ||.||||    | |. ||..|...|.|||| ||||| | .|
tllfhafsifnkqpmlievnsp....inicgdihgqfsdllrlfdkngfphran.ylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QMYGFDGEVKAKYP-----YLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPS-EGPMCDLLWSDPQ-PQPGRSASKRGVGIQFG
..|||  |.. .|      . |  |.  .||  |. ...|.||||. |    .. .||.| |  . |  .    |.|||||   | |     |||   ||
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggv.skmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfg

PDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKP
 |   |.     ..|..|.|.|  .|||.. . . .|||||| || |. |  | . .  .|  
sdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvc
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 202-454 1.1e-53 175.5 In-house 27-281 (307) alignment 
Range on Protein: 202-454
Range on HMM: 27-281/307.0
MILKQAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSkENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMN
 .. .|. .|    .|..|  |      | ||.|||| ||.|.| | | |  |  |.| ||.|||| .| |.|. ||..|. |||.  . ||||| . .|
nviyeaqtifssekalvdidpp....cvvvgdlhgqfndlinmfillgrpp.etvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvn

QMYGFDGEVKAKYPY-------LFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQPQP-GRSASKRGVGIQF
. |||  |. .  |        ||  ..| ||.  ||  |.|.||||| |     ||.||   .  . |  | . |.||.||.|      || || |. |
kkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhggl.spaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftf

GPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDD
| .. .  ||  |.|||||.|..  .|| |.   | ||||||| ||.   | |. . . . 
gtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdet
PPP_1 204-450 4.1e-90 294.6 In-house 6-263 (264) alignment 
Range on Protein: 204-450
Range on HMM: 6-263/264.0
LKQAKVMFEKMPSLIEITIPKGKTFTVCGDIHGQFYDLlNIFKLNGLPSKENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQM
|.. | . .....  |...   .  ||||||||||.|| ...  .|.||.|. |||.||.||||..|.|....|...|| ||...|. ||||||......
laelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkv

YGFDGEVK-----AKYPYLFTEVYNWLPLCHLINKKVLVMHGGLFSTDGiKLDDLRTISRNKQPPSEGPMCDLL--------WSDPQPQPGRSASKRGVG
|||  ||.     ..   ..|.|...|||. ||..|.|..|||| ..    ||. |...|... |.||..||||        ..|.. . . . |.||.|
ygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeld.lldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGag

IQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFIT
 .||.|.||||.. |.|.||||.||||.||||.....|..|||||.||.....|.||...
ylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_PPG1_pd Subfamily PPG1 206-467 5.2e-64 209.4 In-house 25-298 (300) alignment 
Range on Protein: 206-467
Range on HMM: 25-298/300.0
QAKVMFEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGlPSKENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYG
. | .. |   .|||  |     || ||.||||||.|.|||. | .  .  ||| ||.|||| .| | |  |  .|| ||    . ||||||  . |.||
klkellvkesnvieirsp....vtvvgdvhgqfydvleifkigg.qvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvyg

FDGEVKAKY------PYLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQ-------PQPGRSA-----SKR
| .|.  ||         .||....| |. .|.... ..|||| | .   .|... . | .. | || ..|||||||.        .| |.      |.|
fyteclrkyggnsrvwkylteifdylvlaaiideeiycvhggl.spsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqhfvvsqr

GVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYEAVPH
| |  .| |..||| . | .. |||.|..  |||... |.|  |..|||||| . ||| . . . . ..  | .||. |.
gagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 211-468 1.9e-55 181.3 In-house 22-278 (280) alignment 
Range on Protein: 211-468
Range on HMM: 22-278/280.0
FEKMPSLIEITIPkgktFTVCGDIHGQFYDLLNIFKLNGLPSkENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEV
| .   |.|   |      | |||| |. |.  .| | |    |.  .| ||.||||    ||.  || .|. | .. .. |||||. |.|..|||  |.
fmeesnlceaeap....ikvigdihaqyqdmnrlfdligrvp.eeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvec

KAKYP----YLFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQPQ-PGRSASKRGVGIQFGPDITEKFCKDN
. ||     . |  ..| .|.. ||.|.||.||||| | . |.|| .| | |  .|   | . |||||||  .  |   | ||.   ||  . |. ||  
qykygvglwwdfqscfnrmpmsgliskrvlcmhggl.spelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvveqacksl

GLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYEAVPHP
 ..||||.|.|  .|||.|   . ||.|| |||| |. |  | . .  .|.  |      | |
eidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippplp
subfamily_PPP6C_pd Subfamily PPP6C 223-467 3.2e-70 229.5 In-house 39-286 (290) alignment 
Range on Protein: 223-467
Range on HMM: 39-286/290.0
PKGKTFTVCGDIHGQFYDLLNIFKLNGLPSkENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYPY-----L
|     |||||||||||||...|.  |    .. |.| ||||||| .| | .  |...|. ||..  . ||||||  . |.|||  | . ||        
pvsspvtvcgdihgqfydleelfrtggqvp.dtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqitqvygfydeclnkygnanawky

FTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPMCDLLWSDPQPQPGRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVK
.|.|.. |... .|...|| .|||| |.|   ||..|.|.|... | .|..|||.||||.     . |.|| |  ||  .|..|.. | |.||.|.|.. 
ctkvfdlltiaaiideqvlcvhGgl.spdvktldqirvieraqeiphkgafcdlvwsdpedvetwavsprgagylfgskvtkefvhinnlklicrahqlv

PEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYEAVPH
 ||.. | | | .|..|||||| . ||  . ... |. . ..  ..|||.
eeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpd
Metallophos Calcineurin-like phosphoesterase 227-418 1.6e-42 139.0 Pfam-A 2-200 (200) alignment 
Range on Protein: 227-418
Range on HMM: 2-200/200.0
TFTVCGDIHGQFYDL---LNIFKLNGLPSKENPYLFNGDFVDRGSFSCEVIFTL--FSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVK----------
...|.||.||...||   |.|.. .. ..| ...||.||.||||  | |..  |  .. |||.| ..|. ||||||...|. |||  |.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

----------------------------AKYPYLFTEVYNWLPLCHLINKKVLVMHGGLFSTDGIKLDDlrtisrnkqppsegpmcdllwsdpqpqpgrs
                             .. . . |....|||..|...|.|..||.|.|..|  .|                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

askrgVGIQFGPDITEKFCKDNGLELIIRSHEVKP
      .  |||| .||.....|. |..|.|. ||
.....gselfgpdalekllekygvdlvlrGHtHkp
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 228-454 3.9e-46 150.8 In-house 9-245 (263) alignment 
Range on Protein: 228-454
Range on HMM: 9-245/263.0
FTVCGDIHGQFYDLLNIFKLNGLPSKENpYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYP---------YLF
  .||| |||. ||| ||.  |  .| . ||| ||.|||| .| |||. |||.||  | .... |||||  ..|. |||  |.| ..            |
inicgdthgqyndllrifnacgaatktq.ylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynhf

TEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLDDLRTISRNKQPPSEGPM-CDLLWSDPQPQP-GRS-ASKRGVGIQFGPDITEKFCKDNGLELIIRSHE
 .|....||| ...|..|.||||. |     |||.|.|    .     |. |||||.||. .  |      | .   ||    . .||   ..||.|.|.
nqvfsymplcaivskrilcmhggi.sphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrahq

VKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDD
|   || .. | . ||.|||  |  .. |  | . .   
vveygyaffadrrlitvfsasryqielcnyaavvvvnkm
PPP_4 229-417 6.1e-71 231.5 In-house 2-197 (197) alignment 
Range on Protein: 229-417
Range on HMM: 2-197/197.0
TVCGDIHGQFYDL-LNIFKLNGLPSKENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAK----YPYLFTEVYN
||.||||||..|| |...|. ||||.|. |.|.||.||||..|.||. .|...|| ||..... ||||||.|.|..|||  ||. |        ...|..
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

WLPLCHLINKKVLVMHGGLFSTDGiKLDDLRTISRNKQPP-SEGPMCDL-LWSDPQ-PQPGRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVK
.|||..||..||||.||||...   .||....|.|... | .|. ..|| |||||.  | | . |.||.|. ||||.||||...|.|.|||||||.|
llplaalidekvlvvhgglsdele.sldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshelk
PPP_2 229-417 1.6e-69 226.6 In-house 2-198 (198) alignment 
Range on Protein: 229-417
Range on HMM: 2-198/198.0
TVCGDIHGQFYDLlNIFKLNGLPSKENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVK-----AKYPYLFTEVYN
|||||.|||..|| .|.. |||||.|. |||.||.||||..|.||...|...|| ||..... ||||||...|..|||  ||.     .|    ..||..
tvcGDlHGqldDL.lilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

WLPLCHLINKKVLVMHGGLFSTDGiKLDDLRTISRNKQPPSEGPMCDL-----LWSDPQPQPGRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVK
.|||..||..||||.||||...   .||. ....|... |.||...||     |..... . . . |.||.|. ||||.||.....| |.||||.||||
lLplaalidekvlvvHGGlseeik.lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHevk
PPP_5_Dcr2 229-417 3.5e-68 222.5 In-house 2-199 (199) alignment 
Range on Protein: 229-417
Range on HMM: 2-199/199.0
TVCGDIHGQFYDLLNIFKLNG-LPSKENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAK-----YPYLFTEVY
|||||.|||..||| |.  .| .||.|. |.|.||.||||..|.||. .|...||.||..... |||||....|..|||  ||. |         ...|.
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NWLPLCHLINKKVLVMHGGLFSTDGiKLDDLRTISRNKQPP-SEGPMCDL-LWSDPQ-PQPG-RSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVK
.||||..||..||||.||||...   ....|. | |... | ..| ..|| |||||.  | |    |.||.|. ||||.||||...|.|.|||||||.|
dwlPlaalidekvlvvhgglspeik.siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_PPPLV_pd Subfamily PPPLV 229-450 6.5e-37 120.4 In-house 27-274 (290) alignment 
Range on Protein: 229-450
Range on HMM: 27-274/290.0
TVCGDIHGQFYDLLNI---FKLNGLPSKENPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYPY-------LF
 | ||.||.. ||  .   .   |       .|| ||.|||| || |.|  |.. |.||| .... |||||  |. . . . || . |.          |
yvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieykgegsfkfgdsleevweaf

TEVYNWLPLCHLINKKVLVMHGGLFS--TDGIKLDDLRTISRNKQPPSEG-PM-CDLLWSDPQPQPG-------------RSASKRGVGIQFGPDITEKF
..|...|||   |..||. .|.|.      . ..  .. |  . . . .| |.  |.|||||. .                . ..|| |  |. |  |.|
nnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvlneGfvdndrrGtghvfsedaleaf

CKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQmGNKGAFIT
 | |.|. ..|.|||| .|... ..|. .|.||. .|| .  |. | | 
lkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalil
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 255-462 9.6e-60 195.4 In-house 101-312 (317) alignment 
Range on Protein: 255-462
Range on HMM: 101-312/317.0
NPYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYPY----LFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKL
. ||| ||.|||| || ||.  ||..|||||.. |. |||||| ..|. |||  ||| .|       |  ..| |||| ..|||.| ||||. | . ..|
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGi.seelldl

DDLRTISRNKQPPSEGPMCDLLWSDPQPQP-GRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFI
. | .. |  . |  | ..|| |.||...  |   |.|| |  ||..  ..|.|   |.|..|.|.|  .||| . | | .||||||.|| |. | .| .
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

TMGDDLKPKFTTY
.. ..||  ....
svdkklkisinvl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 256-456 1.4e-46 152.2 In-house 121-325 (339) alignment 
Range on Protein: 256-456
Range on HMM: 121-325/339.0
PYLFNGDFVDRGSFSCEVIFTLFSFKLLYPEHFFMSRGNHESSSMNQMYGFDGEVKAKYPY----LFTEVYNWLPLCHLINKKVLVMHGGLfSTDGIKLD
 ||| ||.|||| || ||.  | ..|| ||.. .. |||||| |.|  |||  ||. .|       | ...| .|.| .||. ...||||. |     ..
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggi.sehltsfn

DLRTISRNKQPPSEGPMCDLLWSDPQPQ-PGRSASKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFIT
..  . |  . |  | . || |.||.|   |   | ||  . |||     | |   |...|| |.|  .|||..   . .||||||||| |  |  | ..
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

MGDDLK
.   ||
idkklk
subfamily_PPP7C_pd Subfamily PPP7C 368-465 2.4e-34 111.7 In-house 237-335 (383) alignment 
Range on Protein: 368-465
Range on HMM: 237-335/383.0
MCDLLWSDPQPQPGRSA-SKRGVGIQFGPDITEKFCKDNGLELIIRSHEVKPEGYEVMHDGKCITIFSAPNYCDQMGNKGAFITMGDDLKPKFTTYEAV
. |.|||||. . |  . . || |. ||||.|.|. .  .|.|.||||| ||||||..|| |..||||| || ..  |.||.. .|.||.|..  | | 
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas