Gene PFKFB-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP127_AA protein Get Run
NvecP127_AA_274-471 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 67-280 1.5e-89 289.2 Pfam-A 7-222 (223) alignment 
Range on Protein: 67-280
Range on HMM: 7-222/223.0
PRFVNVPTVIVLVGLPARGKTYMAKKLGRYLNWIGIQCKVFNVGEYRRKAVGMDKLHDFFKVDNQEAQAIRRQCAIDCLNDVSSWLD-EGVQAAIFDATN
... | ..||||||||||||||..||| |||.|.|...||||||.|||.||  ..  .||. ||.||...|...| . |.|. ..|  |. | |||||||
knlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaifDAtN

TTRERRRMVLDYCRRRGYKTFFMESVCNNSEIVASNIKEVKVFSPDYKEVDKEQAFNDFKERIKHYQAAYEPLT-MEDGDLSFIKIINAGEQYLVNNIDG
||||||...|. ......|..|.||||.. ||...||||||. |||||. ..|.| .||..|...|...||||.  || .||.||.|..|....|||. |
ttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvvnnvqg

YLQSKSVYFLMNLHVR
||||. ||.|.|.|. 
ylqsrivyyllNihlk
Zeta_toxin Zeta toxin 72-184 8.5e-06 15.1 Pfam-A 15-122 (201) alignment 
Range on Protein: 72-184
Range on HMM: 15-122/201.0
VPTVIVLVGLPARGKTYMAKKLGRYLNwiGIQCKVFNVGEYRRKAVGMDKLHDffKvDNQEAQAIRRQCAIDCLNDVSSWLDEGVQAAIFDATNTTRERR
 |....|.| |. |||..|..| . |.  . .. ...  |.|..   ...| .  | | .||  . .. |      .  .. |. .  |.. | .. .  
kpkavllgGqpGAGKtslaellleela..agnivridaDelrkfhpeyrelek..k.dpkeaseltqkdaselveklidralekgyniilegtlrspdka

RMVLDYCRRRGYK
| . .  ...|||
rkiarklkkagyk
AAA_33 AAA domain 75-227 8e-11 32.5 Pfam-A 1-139 (143) alignment 
Range on Protein: 75-227
Range on HMM: 1-139/143.0
VIVLVGLPARGKTYMAKKLGRYLNwigiqCKVFNVGEYRRKAVGmdklhdfFKVDNQEAQAIRRQCAIDCLNDVSSW-LDEGvQAAIFDATNTTRERRRM
...|||||. ||.. |..| . |      . . .  ..||.  |        . .... .. ... ....||..  . | .| ...|.||||..||.|. 
lvllvGlpGsGKstlaerllkklg.....yvrlsqdtlrrrlfg.......tdqqsltdytrvlkrlyqilnklarkalsag.rsvivdatnlsreerar

VLDYCRRRGYKTFFMESVCNNSEIVASNIKevKVFSPDYKEVDKEQAFNDFKER
... ..| |..   .   .  ... . . |  .  . |..   .|.|......|
fvklakrlgvpvrivylevpeetlaeRlak..Rerngddrsevpeealdrmlar
AAA_17 AAA domain 75-144 1.3e-08 26.2 Pfam-A 1-77 (121) alignment 
Range on Protein: 75-144
Range on HMM: 1-77/121.0
VIVLVGLPARGKTYMAKKLGRYLNwigiqCKVFNVGEYRrKAVGMDKLHDFFKV----DNQEAQAIRRQ---------CAIDC
||...| |. ||...||.| ..|.     ..|.. .... .. |. .|.| ..     |... .||  .           ||.
viaitGppGsGKsTlakeLaerlg.....lpvlslddll.reeglkelddgereskdadadllaaildglaakkdtlswvidg
KTI12 Chromatin associated protein KTI12 76-204 4.6e-07 19.2 Pfam-A 4-119 (270) alignment 
Range on Protein: 76-204
Range on HMM: 4-119/270.0
IVLVGLPARGKTYMAKKLGRYLNWIGIQCKVFNVGEYRrkavgMDKLHdfFKvDNQEAQAIRRQCaidcLNDVSSWLDEGvQAAIFDATNTTRERRRMVL
.|| |||. ||. .||.| ..|.  |... | .  ...     ..| .  .| |... .|.| .      ..|.  |..  .  | |..| ..  |.   
vvltGlPssGKstvakeLakaleeegrsvvvisdeslg.....iekds..yk.dskkekalRssl....rsavkrdLske.kvVIvDslnYikgfRyeLy

DYCRRRGYKTFFMESVCNNSEIVASNIKE
  .. .  .    . |..  ..|  | ..
clakeakttlcvvyvvapletlvkwneer
0037864 Phosphoglycerate mutase-like 275-467 1.2e-43 141.3 In-house 1-206 (211) alignment 
Range on Protein: 275-467
Range on HMM: 1-206/211.0
MNLHVRKRSIYLVRHAECENNVHQLLGG--DTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYI----QH--APVEPWKALNEIDYGIYD
|.|... . .|||||.| | |. ..| |  |..||..| | |. |.... ....|   |..| |.||.|||..|    ..   ||| ...|.|.|.|...
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgale

GRPVSDLNTMGPDDIKARHKNMFIYRYPLGESYSDVCARLEPVIMELERQ-----NNVVLIVHEAVMQIIMAYFTNHTPDEIPNLDIPLHTVFKLTPIAY
|......  . |..  |.. ... .|.| |||. ||.||..|...|| ..     .||... | .|. ...||... ...|...| .| ..|..|.   .
gltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvlelddg

GCRVER
|.....
gwvlvs
subfamily_PFKFB_pd Subfamily PFKFB 276-471 4.5e-85 276.1 In-house 1-196 (198) alignment 
Range on Protein: 276-471
Range on HMM: 1-196/198.0
NLHVRKRSIYLVRHAECENNVHQLLGGDTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIqHAPVEPWKALNEIDYGIYDGRPVSDLNT
|.|...|.||||||.|.|.|... .|||..||.||.|.|..|| ||.|... .|.||||.|||..|||... ..|.| ||||.|.| | .||  ......
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlkelrvwtselkrtiqTaell.glpkeqwkaLdeldaGkcdgltyeeike

MGPDDIKARHKNMFIYRYPLGESYSDVCARLEPVIMELER-QNNVVLIVHEAVMQIIMAYFTNHTPDEIPNLDIPLHTVFKLTPIAYGCRVERFPLE
. |...|.|.|... |||| ||||.|...||||||.|||| |.||..|.|.||.....||..... .|.|.|..|||||.||||.||||.||.. |.
kfpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkld
0049178 Phosphoglycerate mutase-like 282-468 1.4e-44 144.8 In-house 4-226 (243) alignment 
Range on Protein: 282-468
Range on HMM: 4-226/243.0
RSIYLVRHAECENNVHQLLGG--DTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYI-----QH-APVEPWKALNEIDYGIYDGRPVSDL
. .|||||.| | |. ..| |  |..||..| | |. |.... |....   |..| ||||.|||..|     ..  ||. ...|.|.|.|...|......
trlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltkaei

NTMGPDDIKARHKNMFIYRY-----------------------PLGESYSDVCARLEPVIMELERQ-----NNVVLIVHEAVMQIIMAYFTNHTPDEIPN
 .. |... |.. . . .|.                       | |||. ||.||..|...|| ..     ..|... | .|. ...|........|...
aakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleellr

LDIPLHTVFKLTPIAYGCRVERF
|..| ..|..|.   .|......
lnlpngsvtvlelddggwvlvsl
0051064 Phosphoglycerate mutase-like 282-465 6e-44 143.1 In-house 4-225 (241) alignment 
Range on Protein: 282-465
Range on HMM: 4-225/241.0
RSIYLVRHAECENNVHQLLGG--DTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIQH------APVEPWKALNEIDYGIYDGRPVSDL
. .|||||.| | |. ..| |  |..||..| | |. |.... ...|.  .|..| |.||.|||..|         ||. ...|.|||.|...|......
krlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltleei

NTMGPDDIKARHKNMFIYRY-------------------------PLGESYSDVCARLEPVIMELERQ-----NNVVLIVHEAVMQIIMAYFTNHTPDEI
 .. |... |.. . . .|.                         | |||. ||.||..|.. || ..     .||... | .|. ...||.......|.
aekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglpleel

PNLDIPLHTVFKLTPIAYGCRV
..|..| ..|..|.  ..|.||
lrlnlpngsvtvleldddgkrv
0043909 Phosphoglycerate mutase-like 282-465 4.2e-43 139.9 In-house 3-231 (249) alignment 
Range on Protein: 282-465
Range on HMM: 3-231/249.0
RSIYLVRHAECENNVHQLLGG--DTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIQH------APVEPWKALNEIDYGIYDGRPVSDL
. .|||||.| | |.  .. |  |..||..| | |. |.... |..||  .|..| ||||.|||..|         ||| ...|.|.|.|...|......
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfdavysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltkaei

NTMGPDDIKARHK-----------------------------NMFIYRYPLGESYSDVCARLEPVIMELERQ-----NNVVLIVHEAVMQIIMAYFTNHT
  . |..  |..                              . . .|.| |||. ||.||..|...|| ..     .||... | .|. ...||... .
aekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllgls

PDEIPNLDIPLHTVFKLTPIAYGC---RV
...|..| .| .....|.. ..|.   ..
ledilrlnlpngsitvlelddggkpvvvl
subfamily_PGAM5_pd Subfamily PGAM5 282-357 4.3e-06 18.0 In-house 2-75 (189) alignment 
Range on Protein: 282-357
Range on HMM: 2-75/189.0
RSIYLVRHAECENNVHQllgGDTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYI-QHAPVEPWKAL
| . ||||.. ... ..    .  ||..| . |...   ..| ...  |. .| . |||.||. | .. | .| |. 
rhlilvrhgqyvlddds...dkkiltelGrrqaeltGkrlkelnlkftklvastmvravetadiiskqlpdvpkktk
0053607 Phosphoglycerate mutase-like 283-467 1.6e-47 153.7 In-house 3-186 (191) alignment 
Range on Protein: 283-467
Range on HMM: 3-186/191.0
SIYLVRHAECENNVHQLLGGDTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIqHAPVEPWKALNEIDYGIYDGRPVSDLNTMGPDDIK
 .|||||.| | |.. .| ||..||..| | |. ||... |....  .|..| |.||.|||..| . ||| ...|.|||.|...|.....|  . |... 
rlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfdavysSpllRarqTaeii.glpvevdprlrEidfgdwegltleelaekypeela

ARHKNMFIYRYPLGESYSDVCARLEPVIMELERQNNVVLIVHEAVMQIIMAYFTNHTPDEIPNLDIPLHTVFKLTPIAYGCRVER
|.... . ||.| |||. ||.||..|...|| ...||... | .|.....||.......|...|..| ..|..|..  .|.....
awlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvlvl
0036777 Phosphoglycerate mutase-like 283-465 4.1e-43 140.1 In-house 4-226 (247) alignment 
Range on Protein: 283-465
Range on HMM: 4-226/247.0
SIYLVRHAECENNVHQLLGG--DTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIQH------APVEPWKALNEIDYGIYDGRPVSDLN
 .|||||.| | |.  .. |  |..||..| | |. |.... |...|  .|..| |.||.|||..|         ||. ...|.|.|||...|.. ... 
rlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkaeia

TMGPDDIKARHKNMFIYRY-------------------------PLGESYSDVCARLEPVIMELERQ-----NNVVLIVHEAVMQIIMAYFTNHTPDEIP
 . |..  |.. . . ||.                         | |||. ||.||..|...|| ..     .||... | .|. ...||... ....|.
ekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsledil

NLDIPLHTVFKLTPIAYG--CRV
.| .| .....|.  ..|   ..
rlnlpngsitvleldddgklwvl
0036887 Phosphoglycerate mutase-like 283-467 1.1e-41 134.9 In-house 3-194 (202) alignment 
Range on Protein: 283-467
Range on HMM: 3-194/202.0
SIYLVRHAECENNVHQLLGG--DTDLTKRGDEFAQTLAAFINeqDIPDLKVWTSQLKRAVQTAKYIQ---HAPVEPWKALNEIDYGIYDGRPVSDLNTMG
 .|||||.| | || ..| |  |..||..| | |. |....   ..|   |..| |.||.|||..|    . ||. ...|.|||.|...|......  . 
rlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla..glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeiaeky

PDDIKARHKNMFIYRYPLGESYSDVCARLEPVIMELERQ---NNVVLIVHEAVMQIIMAYFTNHTPDEIPNLD-IPLHTVFKLTPIAYGCRVER
|.. .|.. ... .|.| |||. ||.||......|| ..   .||... | .|. ...||... .......|. .| ..|..|.  ..|.....
peelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvlvl
subfamily_TIGAR_pd Subfamily TIGAR 283-417 2.4e-12 39.0 In-house 2-138 (222) alignment 
Range on Protein: 283-417
Range on HMM: 2-138/222.0
SIYLVRHAECENNVHQLLGGD--TDLTKRGDEFAQTLAAFINEQDIPdlKVWTSQLKRAVQTAKYI-------QHAPVEPWKALNEIDYGIYDGRPVSDL
....||| | | | ...| |   | |. .| | |. .| ..... |    . .| |.|| |||..|       ....||  | | | .||.| |  ...|
ilivVrhGetefnkekilqgqtdtpLsekGveQakrvakrLsnekin..yifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldel

NTMgpddIKARHkNMFIYRYPLGESYSDVCARLEPVIMELERQN
. .    .||.  |.     . |||   . .|| . . || ...
rel....lkaag.nvpsfvpegGesieqlelrlvaaleelcaki
0039931 Phosphoglycerate mutase-like 284-471 1.7e-51 167.0 In-house 2-188 (219) alignment 
Range on Protein: 284-471
Range on HMM: 2-188/219.0
IYLVRHAECENNVHQLLGGDTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIqHAPVEPWKALNEIDYGIYDGRPVSDLNTMGPDDIKA
.|||||.| | ||  .| ||..||.|| | |. |.... ....|   |..| |.||.|||..| . ||| ...|.|||.|...|......  . |... |
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpfdavysSpllRaiqTaeii.glpveidprLrEidfgdlegltleeiaekypeelaa

RHKNMFIYRYPLGESYSDVCARLEPVIMELERQNNVVLIVHEAVMQIIMAYFTNHTPDEIPNLDIPLHTVFKLTPIAYGCRVERFPLE
.... . ||.| |||. ||.||..|...||....||... | .|.....||... ...||..|..| ..| .|.. ..|...... | 
wlrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvllnlt
0035570 Phosphoglycerate mutase-like 284-466 9.4e-51 164.6 In-house 2-183 (219) alignment 
Range on Protein: 284-466
Range on HMM: 2-183/219.0
IYLVRHAECENNVHQLLGGDTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIqHAPVEPWKALNEIDYGIYDGRPVSDLNTMGPDDIKA
.|||||.| | |.  .| ||..||.|| | |. |.... ...||  .|..| |.||.|||..| . ||| ...|.|||.|...|...... .. |.. .|
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlgipfdavysSpllRaiqTaeii.glpveidprLrEidfgdlegltldeiaekypeelaa

RHKNMFIYRYPLGESYSDVCARLEPVIMELERQNNVVLIVHEAVMQIIMAYFTNHTPDEIPNLDIPLHTVFKLTPIAYGCRVE
.. . . ||.| |||. ||.||..|...|||...||... | .|.....||... ...||..|..| ..| .|.. ..|....
wlrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwv
0048955 Phosphoglycerate mutase-like 284-465 1.6e-42 138.3 In-house 3-222 (240) alignment 
Range on Protein: 284-465
Range on HMM: 3-222/240.0
IYLVRHAECENNVHQLLGG--DTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIQH------APVEPWKALNEIDYGIYDGRPVSDLNT
.|||||.| | |.  .| |  | .||..| | |. |.... ...|.  .|..| |.||.|||..|         ||. . .|.|.|.|...|......  
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeiae

MGPDDIKARHKNMFIYRY-------------------------PLGESYSDVCARLEPVIMELE-----RQNNVVLIVHEAVMQIIMAYFTNHTPDEIPN
. |... ... . . .|.                         | |||. ||.||..... ||      ...||... | .|.  ..||... ...||..
kfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeilr

LDIPLHTVFKLTPIAYGCRV
|.|| . |..|.   .. ..
lnipngsvtvlelddglvsl
0050036 Phosphoglycerate mutase-like 284-456 2.9e-38 123.1 In-house 3-165 (171) alignment 
Range on Protein: 284-456
Range on HMM: 3-165/171.0
IYLVRHAECENNVHQLLGG--DTDLTKRGDEFAQTLAAFIneqdiPDLKVWTSQLKRAVQTAKYIQhAPVEPWKALNEIDYGIYDGRPVSDLNTMGPDdi
.|||||.| | |. ... |  |..||..| . |. |....     |   |..| |.||.|||..|   ||. ...|.|.|.|...|......  . |.  
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell.....pfdavysSpllRArqTaelil.lpvivdprLrErdfGawegltldeiaakype..

kaRHKNMFIYRYPLGESYSDVCARLEPVIMELErqNNVVLIVHEAVMQIIMAYFTNHTPDEIPNLDIPLHTVFKL
  ...... ...| |||. ||.||. |.. ||   .||... | .|. ...|.... ...||..|..| ..|. |
..wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvl
His_Phos_1 Histidine phosphatase superfamily (branch 1) 284-430 2e-31 102.1 Pfam-A 2-157 (158) alignment 
Range on Protein: 284-430
Range on HMM: 2-157/158.0
IYLVRHAECENNVHQLLGGDTD--LTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIQH---APVEPWKALNEIDYGIYDGRPVSDLNTMGP
.|||||.| | |  . | |..|  ||..| | |. |.. . ..|.|  .|.||.||||.|||....     |..  ..|.|.|.| ..|.| .... . |
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

DDIKARHKNMFIYRYPLGESYSDVCARLEPVIMELE----RQNNVVLIVHEAVMQI
.. ...... . .|.| |||. ||..|..|...||     ...||... |..|.. 
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlra
His_Phos_1 Histidine phosphatase superfamily (branch 1) 284-430 2e-31 102.1 In-house 2-157 (158) alignment 
Range on Protein: 284-430
Range on HMM: 2-157/158.0
IYLVRHAECENNVHQLLGGDTD--LTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIQH---APVEPWKALNEIDYGIYDGRPVSDLNTMGP
.|||||.| | |  . | |..|  ||..| | |. |.. . ..|.|  .|.||.||||.|||....     |..  ..|.|.|.| ..|.| .... . |
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpidavytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeefp

DDIKARHKNMFIYRYPLGESYSDVCARLEPVIMELE----RQNNVVLIVHEAVMQI
.. ...... . .|.| |||. ||..|..|...||     ...||... |..|.. 
eeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlra
subfamily_PGAM_pd Subfamily PGAM 284-368 2.2e-10 32.2 In-house 3-95 (248) alignment 
Range on Protein: 284-368
Range on HMM: 3-95/248.0
IYLVRHAECENNVHQLLGG--DTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIQ------HAPVEPWKALNEIDYGIYDGR
. |.|| | | |  . . |  |..|...| | |....  ......   .|.||.||||.||.. |         |||    |||  ||   | 
lvllRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlefdivytSvlkRaqqTlevileeldqekiPvektwrLnErhyGaltgl
subfamily_STS_pd Subfamily STS 303-432 4.9e-06 18.1 In-house 52-193 (245) alignment 
Range on Protein: 303-432
Range on HMM: 52-193/245.0
DTDLTKRGDEFAQTLAAFINEQDIPDLKVWTSQLKRAVQTAKYIQHAPVepWKALNEIDYGIYDGR---------PV--SDLNTMGPDdIKARHKNMFIY
|. ||.||   |..|.  . |..|    .. |   | .|||. |  .     |.  ....|...           ..  ..|....|. |    | ..  
DpPlterGviqAkllgraLleagikiehifcSPslrciqTaaailkglg..kkikikvepgllewlkldrkpipellspeelkkffpq.idedYkpvlsl

RY-PLGESYSDVCARLEPVIMELERQN---NVVLIVHEAVMQIIM
     .||.... .| . |. |.  .    . .||| .|.. ...
selkskeseeelyeRikkvvkeiiekvpedgniliVahaatldal