Gene ILKAP in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily ILKAP
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP137_AA protein Get Run
NvecP137_AA_95-389 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 96-389 5.9e-68 221.7 In-house 10-287 (295) alignment 
Range on Protein: 96-389
Range on HMM: 10-287/295.0
KKLATGVKLYKLKGFFAERKGEREEMQDAHVIRDEYYPEPGRgddvqrMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPKG--SITGKDKEIKKCLVDA
 .| .   |..|. ..|  .| |....||...  ....  .       .....||||| | .|. .|.|.|.|.... . |   . |  .  |...|..|
ellllsslllllrvgvasdqGrrksneDavlvvlnllslled......lllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrka

YTLTDEQFLHEASKGTPVWKDGSTAVSVLVINNTLYVANLGDSKALVCRCDsagkiSVVRLSKDHSPTGYDERMRIQKAGGYVKDGRVLGVLEVSRSIGD
.  .||..|..| .   ..  |.||| .|...|.|||||.|||.|...| .      .|.|..||.|. ..||.||..|||.| .|||.||| |.|..||
flaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrng.....elvqltvdhkpvnelererilsaggavshgrvngvlavtRalGd

GRFK--------RCGVISTPDIMRCTLT-DNDRFLLLACDGLWKGFSVDEAVKYISKILDVRYTyiltneepgldpvearFQLACDRIASDAVRNGSSDN
 ..|        . .|...||..  .|| ..| |||||.||||. .| .|.|..... |  ...                 . |.....  |...||.||
fdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgld................leeaaeeLvdlAlargsrDN

VTVML
.||..
iTvvv
subfamily_ILKAP_pd Subfamily ILKAP 104-389 2.2e-142 466.4 In-house 2-289 (293) alignment 
Range on Protein: 104-389
Range on HMM: 2-289/293.0
LYKLKGFFAERKGEREEMQDAHVIRDEYYPEPGRGDD-VQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPKGSITGKDKEIKKCLVDAYTLTDEQFL
||||||..||||||||||||||||.......... .. |.|..||||||||||.||| ||||.||..|....||.... |.|||||||||... |||.||
lyklkgayaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefL

HEASKGTPVWKDGSTAVSVLVINNTLYVANLGDSKALVCRCDSAGK-ISVVRLSKDHSPTGYDERMRIQKAGGYVKDGRVLGVLEVSRSIGDGRFKRCGV
..|||..|||||||||..|||..|.|||||||||||...|....|. |..|.|.|||.|. |.||.|||||||.|.|||||||||||||||||||||.||
klaskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlGv

ISTPDIMRCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILDVRYTYILTNEEPGLDPVEARFQLACDRIASDAVRNGSSDNVTVML
|||||...|.||.||.|..||||||||.||.||.||.|.|.|. ....  ..||....  |.||..||.|.||.||..||||||||.|
istPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkikeeekkskeevrfevacnrlaseavkrgssdnvtvll
subfamily_PPM1G_pd Subfamily PPM1G 105-205 1.7e-09 30.2 In-house 17-103 (473) alignment 
Range on Protein: 105-205
Range on HMM: 17-103/473.0
YKLKGFFAERKGEREEMQDAHVIRDEYypepgrgddVQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRmpkgsITGKDKEIKKCLVDAYTLTDEQFLHE
 .|.  ..  .| |... |||    .           . .. .||.||| |   . . |..| . .| .      . |. ...|.| .|.   ||.   |
eelsygasamqGwrvsqEDahncitdl.........dedtslfavyDGHGGkevakyvakklpdllkaq.....kgykegdvekaleeaflalDeklkae

A
.
e
0049733 PP2C-like 109-389 2.3e-52 170.6 In-house 5-230 (235) alignment 
Range on Protein: 109-389
Range on HMM: 5-230/235.0
GFFAERKGE-REEMQDAHVIrdeyypepgrgddvqRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPKgsitGKDKEIKKCLVDAYTLTDEQFLHEASK
 ..| ..|  |....||...                ....||.||| | .|. .|.|.|.|.... . .        .....|..|.. ..|..|..| .
vgaasdigrvrkvneDavlv...............glllfavaDGhgghaagevasellvetllellle....lllldleealrkaflaaneallelala

GTPVWKDGSTAVSVLVINNTLYVANLGDSKALVCRCDSagkisVVRLSKDHSPTGYDERMRIQKAGGYVkdgRVLGVLEVSRSIGDGRFKrcgvistPDI
  ...  |.||| .|.....|||||.||| |...| .      .|.|..||||.  .||.||..|||.|   ||.|.| ..|..||  .|       ||.
spelagmgtTavvalldggklyvanvGDsrayllrdgk.....lvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.......pdv

MRCTLTDNDrFLLLACDGLWKGFSVDEAVKYISKiLDVrytyiltneepgldpvearfQLACDRIASDAVRNGSSDNVTVML
....|...| |||||.||||. .| .|.|..... ||.                    . |..|... |...|. ||.||..
tvlelepgd.flllasDGlwdvlsdeeivdllrs.ldl....................eeaaerlvelalarggrDNiTvvv
PPM_PTC7 110-385 7e-59 192.4 In-house 4-259 (259) alignment 
Range on Protein: 110-385
Range on HMM: 4-259/259.0
FFAERKGEREEMQDAHVIRDEYYPEpgrgDDVQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPKGSITgkdkEIKKCLVDAYTL--TDEQFLH-EAS
 . . .| |..| |||.. .    .    .. .  |..||||||.| .|. .|.|||.| .|.|  . . .    . .|.| ...    ||| .   ||.
gasafqgfrksmedahialanless....sgkdsvaffavfdghggreaakyarehleeilkerksfeele....klekalrksflaldtdeelkssean

kgTPVWKDGSTAVSVLVINNTLYVANLGDSKALVCRCDSAGkisvVRLSKDHSPTGYDERMRIQKAGGYVK---DGRVLGVLEVSRSIGDGRFKR-----
  |  .. |||||..|.....|||||.|||.|..|| . |     ..|..||.|.  ||| ||..|||.|    .||| |||.|||..|| ..|.     
..tepstsGstAvvalitgsklyvAnvGDSravLcrsgnav....kqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketee

CGVISTPDIMRCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILDVRytyiltneepgldpveaRFQLACDRIASDAVRNGSSDNV
. |...|||   .....| ||.||.||||  .| .|||  . . |. .                   . |.......|...||.||.
qlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.................dpmeaaeklvdeaiargsedni
PPM_PTC7_SpoIIE 110-378 2.7e-30 98.9 In-house 4-223 (230) alignment 
Range on Protein: 110-378
Range on HMM: 4-223/230.0
FFAERKGEREEMQDAHVIRDEYYPEpgrgDDVQRMAYYAVFDGHAGPRasLFAAEHLHENIKSRMpKGSITgkdkEIKKCLVDAYTLTDEQFLHEaskgt
 . . .| |..| |||....    .    .. .  ......||| |.    .|...|.. ....  . . .    . ...| ... . . .. .|     
gasaaqgarksmedahispanseks....sggrlalvvgdvdGhGgra..alamgllrtalrela.fagle....kpeeilrrlnlalaadlede.....

pVWKDGSTAVSVLVINNT--LYVANLGDSKALVCRCdSAGkisvvrlskdhsptgydERMRIqKAGGYV-K---DGRVLGVLEVSRSIGDGRFKR--CGV
 ... |.||| .|. ..|  |||||.||| .|..|  ..|                 || || .||| .     .||| |||.||...||  ..     |
.psssgaTavvalidpstgklyvanaGdsppllvrd.dgg.................ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvv

ISTPDIMRCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILDVRytyiltneepgldpvearfqlACDRIASDAVR
 . || ..  | ..|.|| ||.|||| . | .|.|  . . |.                       |......|...
eaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....................aaeglleDDit
PP2C Protein phosphatase 2C 111-385 2.4e-60 197.3 Pfam-A 5-255 (255) alignment 
Range on Protein: 111-385
Range on HMM: 5-255/255.0
FAERKGEREEMQDAHVIRDEYYPEpgrgDDVQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPKGSITgkdkEIKKCLVDAYTL-TDEQFLHEASKgT
. | .| |..| |||.. ..   .    .. .. |..||||||.| .|. .|.|||.| .|..  . . .    . .|.| ...   |||..  .. . |
aselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelksskan.t

PVWKDGSTAVSVLVINNTLYVANLGDSKALVCRCDSAGkisvVRLSKDHSPTGYDERMRIQKAGGYVK-DGRVLGVLEVSRSIGDGRFKR---CGVISTP
  .| |||||..|. ...|||||.|||.|..|| | |     ..|..||.|.  ||| ||..|||.|.  ||| |.|.|||..|| ..|.   . |.. |
epsksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaeP

DIMRCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILDVRYtyiltneepgldpveaRFQLACDRIASDAVRNGSSDNV
|.   .||..| ||.||.||||  .| .|||  . . |.  .                  . |..... .|...||.||.
dvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk................spmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 111-385 2.4e-60 197.3 In-house 5-255 (255) alignment 
Range on Protein: 111-385
Range on HMM: 5-255/255.0
FAERKGEREEMQDAHVIRDEYYPEpgrgDDVQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPKGSITgkdkEIKKCLVDAYTL-TDEQFLHEASKgT
. | .| |..| |||.. ..   .    .. .. |..||||||.| .|. .|.|||.| .|..  . . .    . .|.| ...   |||..  .. . |
aselqgarksmedahialknleks....sgkssvaffavfdghggreaakyarehleeilkeqksflele....kvekalrksfladtdeelksskan.t

PVWKDGSTAVSVLVINNTLYVANLGDSKALVCRCDSAGkisvVRLSKDHSPTGYDERMRIQKAGGYVK-DGRVLGVLEVSRSIGDGRFKR---CGVISTP
  .| |||||..|. ...|||||.|||.|..|| | |     ..|..||.|.  ||| ||..|||.|.  ||| |.|.|||..|| ..|.   . |.. |
epsksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaeP

DIMRCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILDVRYtyiltneepgldpveaRFQLACDRIASDAVRNGSSDNV
|.   .||..| ||.||.||||  .| .|||  . . |.  .                  . |..... .|...||.||.
dvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkk................spmeaaeelvdeaiargsedni
subfamily_PPM1A_pd Subfamily PPM1A 111-389 1.1e-55 181.9 In-house 16-277 (282) alignment 
Range on Protein: 111-389
Range on HMM: 16-277/282.0
FAERKGEREEMQDAHVIRDEYypepgrGdDVQRMAYYAVFDGHAGPRASLFAAEHLHENIKS--RMPK-GSITGKDKEIKKCLVDAYTLTDEQFLHEASK
 .. .| | || |||..  .       |  ..  ...|||||||| ... ....||.||| .  .. .  .   ...|.|. | ...  .||.  .. ..
vssmqgwrvemEDahtvvasl......g.alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstd

GTPVWKDGSTAVSVLVINNTLYVANLGDSKALVCRCDsagkiSVVRLSKDHSPTGYDERMRIQKAGGYVKDGRVLGVLEVSRSIGDGRFKR--------C
 .   | |||||.||| ...|..||||||.|..||       ....|..|| |.  .|. ||..||| |  .|| | | |||..||  .|.         
lktadksGsTavtvlvsekhliianlGDsRavlcrng.....kaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeq

GVISTPDIMRCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILDVRYTYILTneepgldpvearfqlaCDRIASDAVRNGSSDNVTVML
 |.. |... .  ...| ||.|||||.|   | .|.|... | |.| .                     ....   | ..|| ||..|..
lvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleev................akalvdkalekgsrDNlsvlv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 111-344 1.5e-43 142.0 In-house 10-225 (255) alignment 
Range on Protein: 111-344
Range on HMM: 10-225/255.0
FAERKGEREEMQDAHVIRDEYYPEPgrGDDvqrmaYYAVFDGHAGPRASLFAAEHLHENIKSRMPKgsitgKDKEIKKCLVDAYTLTDEQFlheasKGTP
|..  | |  |.|  ||  ..  ..  ..|     |||.||||.| .|. ||.|.|.  ... .       .. . .|.| .||  .. |.     .  |
fsdmiGrrptmedelviyGsfrdks..ded.....yyalfdGhgGraaakfaseelykilaelldl.....nnanPvkslkkaykeistqi.....serp

vWKDGSTAVSVLVINNTLYVANLGDSKALVCRCDSAgkisVVRLSKDHSPTGYDERMRIQKAGGYVKDG----RVLGVLEVSRSIGDGrFKRCGVISTPD
    |.||.|||.|..  |.||.|||....|. |.      .||| || |.  .|. ||...|| |  .    || | | |||..||  |    |.. ||
.kfiGttaasvliiedkvyianvGdsrvvlcqkdgt....akrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGds.flePfvvpdPd

IM-RCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILD
.    . . .|.||.|||||.|   | .|||. . .| |
lsqsleiskkdkflilacdGiwdlisdeeaveivagisd
PP2Cc_SM00332 112-388 7.4e-69 225.2 In-house 15-272 (274) alignment 
Range on Protein: 112-388
Range on HMM: 15-272/274.0
AERKGEREEMQDAHVIRDEYYpepgrgdDVQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPKGSITGkDKEIKKCLVDAYTLTDEQFLHEASKGTP-
.. .|.|..|.||||.. ..          .. ....|||||.|.... |....|.|..|... | . .  .......| .|.  |||..|.|...  . 
ssmqgwrksmeDahvvvvdlv.......eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.eddveealkkaflstdeeileeeqskele

VWKDGSTAVSVLVINNTLYVANLGDSKALVCRCDSagkisVVRLSKDHSPTGYDERMRIQKAGGYVKDGRVLGVLEVSRSIGDGRFKR------CGVIST
 .. |||||..|. ...|||||.|||.| .|| ..     .|.||.||.|   ||| ||.||||.|..||| |.|.|||..||. .|.       .....
nalsGstavvallkkedlyvanvGDSravlcrngk.....avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknkklkepyitae

PDIMRCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILDVRytyiltneepgldpVEARFQLACDRIASDAVRN-GSSDNVTVM
||.  .|||..|.||.||.||||  .| .|.|... |.|. .              .. . | |.....  | |. ||.||.||.
pdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakg..............ktndpqeaaelldeeairrggseDniTvv
subfamily_PPM1E_pd Subfamily PPM1E 114-388 9.1e-52 168.8 In-house 11-258 (265) alignment 
Range on Protein: 114-388
Range on HMM: 11-258/265.0
RKGEREEMQDAHVIRDEYYPEPGRgDDVQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPKG--SItgkdkeikKCLVDAYTLTDEQFLHEASKGtpV
 |..|  | | ||. ...    .  .| .  |..||||||.|  |. .||.||||.. ..      .         . | .|. ||||.||. | .    
vknkrrkmEDrhvaledlnelfel.kdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa........ealkeafkltDerflqkaere..k

WKDGSTAVSVLVINNTLYVANLGDSKALVCRcdsagKISVVRLSKDHSPTGYDERMRIQKAGGYVK---DGRVLGVLEVSRSIGDGRFKRCgVISTPDIM
.| |||||.||. ...|||| ||||.||..|     |...|.| | |.|   ||. ||..||| |      || ||| |||.||| . |.  |.. .|..
lksGstavvvliekdqlyvaWlGDsqallvr.....kgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpy.vsgeadva

RCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILDvrytyiltneepglDPVEARFQLAcDRIASDAVRNGSSDNVTVM
...|.... .|.|||||||  .  .|.|| ... |               |..| . ..|   . . |  .|||||.||.
eveldgseeylilacDGlwDvvneeevvklveefla..............dgaedlseva.kllveaakeagssDnitvv
subfamily_PPM1D_pd Subfamily PPM1D 114-388 3.2e-30 98.3 In-house 9-303 (309) alignment 
Range on Protein: 114-388
Range on HMM: 9-303/309.0
RKGEREEMQDAHVIRDEYYPEPGrgddVQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRmpKGSITGKDKEIKKCLVDAYTLTDEQFLHEASKGTPVW-
..|.|. |.|  .|  |  ..       . .|. |||||| |  |. || ||| ..|| .  |. .. ..... . . .|.  | |.  .. .. ..   
dqGgrkymeDvvaivleeeesae....elevafvavfDGHGGkeAakfarehlwsvikkq..kkflssepedvleAireaflatheamkkkleeWpktks

----KDGSTAVSVLVINNTLYVANLGDSKALVCRCDS-AGKISVVRLSKDHSPTGYDERMRIQKAGGYVKDG----RV-----------------LGVLE
      |.||  |.. .. ||||. |||....   .    |.    | ||| |   .|. ||...|| |..     ||                 .  | 
gllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLa

VSRSIGD-----GRFKRCGVISTPDIMRCTLTDND-RFLLLACDGLWKGFSVDEAVKYISKILDVRYTyilTNE-EpgLDPVEARFQLACDRIASDAVRn
|.||.||      . ..  |   ||..  ||. |. .|..|| ||||.  . ..||. ..|   ....   ..| .   ....|  . | .| .|  .| 
vaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkel...keeqs..rsvakalvkealqrwrskklr.

gsSDNVTVM
  .|||.|.
..aDnvsvi
subfamily_PPM1G2_pd Subfamily PPM1G2 115-343 7.2e-50 162.5 In-house 27-247 (287) alignment 
Range on Protein: 115-343
Range on HMM: 27-247/287.0
KGEREEMQDAHVIRDEYYPEpgrgDDVQRMAYYAVFDGHAGPRASLFAAEHLHENIKSrmpKGSITgkDKEIKKCLVDAYTLTDEQFLHEASKGTpvWKD
.| | .| |||....|   .    .| ...|..|||||| | ... .|...|.. |..   | | .  . .....| ||.  |||..|.. .      . 
qGyrlnmeDahilenellek....sddkslalfavfDGhGGakvakyagkklikkiak...kksfk..egaleqilkdafletDeellkdeklkd..esa

GSTAVSVLVINNTLYVANLGDSKALVCRcdsAGKisVVRLSKDHSPTGYDERMRIQKAGGYVKDGRVLGVLEVSRSIGDGRFKRCG--------VISTPD
|||||.||.... ||||| |||.|...    .|.  |  || || |.  .|. ||..|||.|. .|| |.| .||..||  ||..         |  .||
GstavvvlikeeklyvanaGDsravlss...kgn..vkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPD

IMRCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKIL
..   |...| ||.|||||.|  .. .| |... . |
vlvkkldeddeflvLaCDGiWDvltnkevvdlvrerl
subfamily_PPM1L_pd Subfamily PPM1L 116-344 1.5e-38 125.6 In-house 14-237 (269) alignment 
Range on Protein: 116-344
Range on HMM: 14-237/269.0
GEREEMQDAHVIRDEYypepgrgDDVQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPKGSITGKDKE---IKKCLVDAYTLTDEQFLHEASKGTPVw
| |..|.|   | ..        ..   . ..|||||| |  |. || . | ..||... .     ...|    .| |.|     ||..|..| . . . 
Grrprmedrfeieedi.......knktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedi.

kDGSTAVSVLVINNTLYVANLGDSKALVCrcDSAGKisVVRLSKDHSPTGYDERMRIQKAGGYVK---DGRVLGVLEVSRSIGDGRFKRC-GVISTPDIM
  |.||.  || .. | |||.|||. ...  |  ||   . || || |    || ||.||||..      || ||| .||..||  .|    ||..|||.
.aGttalialvqesdlivanvGdsrGvly..dkrGk..aiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpdil

RCTLTDN-DRFLLLACDGLWKGFSVDEAVKYISKILD
   | |   .||.||.||||  || .|||..| . |.
tfdlddhkpeflilasdGlwdtfsneeavrfikerlk
subfamily_PP2D1_pd Subfamily PP2D1 120-186 7.5e-06 17.9 In-house 16-79 (492) alignment 
Range on Protein: 120-186
Range on HMM: 16-79/492.0
EMQDAHVIRDEYYPEPgrgddvqRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPK----GSITGKDKEI
.|.|.... |.. ...         ......||. |  |   ||..||| . ... |     |.| . . |
kmeDkrtlqdyfgndv.......nscFfgiyDGynGataAeiaakelhevlleelekvdervslttavnli
subfamily_KAPP-like_pd Subfamily KAPP-like 139-346 7.3e-25 80.5 In-house 29-235 (266) alignment 
Range on Protein: 139-346
Range on HMM: 29-235/266.0
DDVQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRMPK--GSITGK-DKEIKKCLVDAYTLTDEQF-LHEASKGT----PVWKDGstavsvlvINNTLYV
 .. ..| .||||||||  |.  | . . ....  . .      |.   . .| | .|.   |...  .|    |     ||.||            | |
sncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdG........qqrylqv

ANLGDSKALVCRCDSAgkisvVRLSKDHSPTGYDERMRIQKAGGYVKDG--RVLGVlEVSRSIGDGRFK--RCGVISTPDIM-RCTLTDNDRFLLLACDG
||.||| |...| . .     . |||||  .  .|. ||.. |  . |.  |. |.  |||..||   |   .|.||.| .  | .||  |.||..| ||
anvGdssaflsrGnes.....lelskdhkakdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkflivasdG

LWKGFSVDEAVKYISKILDVR
||   | ..|.. .. . | .
lwdvisGkdaiekvkslydqq
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 139-346 1.6e-23 76.0 In-house 28-245 (276) alignment 
Range on Protein: 139-346
Range on HMM: 28-245/276.0
DDVQRMAYYAVFDGHAGPRASLFAAEhLHENIKSRMPKG---SITGKD------KEIKKCLVDAYTLTDEQFLHEASKG---T--PVWKDGSTAVSvlVI
 .. ..| .||||||||  |.  | . |  ..  .. |    |.| .|       . .| | |..   |... .   .|   |   ||.||         
sncsnialfavfdGhaGkGaadaakk.lfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqq..qq

NNTLYVANLGDSKALVCRCDSAgkisvVRLSKDHSPTGYDERMRIQKAGGYVKDG--RVLGVlEVSRSIGDGRFK--RCGVISTPDIM-RCTLTDNDRFL
.  | |||.||| |...| . .     . |||||  |  .|. ||.. |  . |.  |. |.  |||..||   |   .|.||.| .  | .||  |.||
qrylqvanvGdssaflsrGnes.....lelskdhkatdpeekqrikddGitlsdnqtrinGl.avsralGdhfikelniGlisepyvsnrilltpfdkfl

LLACDGLWKGFSVDEAVKYISKILDVR
..| ||||   | ..|.. .. . | .
ivasdGlwdvisGkdaiekvkslydqq
subfamily_PPM1H_pd Subfamily PPM1H 141-174 6.8e-08 24.7 In-house 59-92 (404) alignment 
Range on Protein: 141-174
Range on HMM: 59-92/404.0
VQRMAYYAVFDGHAGPRASLFAAEHLHENIKSRM
   .||...||||||. |.| |.. ||. .|...
klplayfglfDGhaGsgaalvaskllhkhlkekl
Subfamily Dicty-PPM1L-like 142-388 2.1e-15 49.4 In-house 35-299 (305) alignment 
Range on Protein: 142-388
Range on HMM: 35-299/305.0
QRMAYYAVFDGHAGPRASLFAAEHLHENIKSR--MPKGSITGKDKEI----KKCLVDAYTLTDEQFLHEASKGTpvWKDGSTA----VSVLVINNTLYVA
| . .. ||||| | .|. ..  .| | . .   . |   . |..       ... .|.  ||. .|  |. .    | |.|      || . .. . |.
qelslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdn..kkaGttlngssasvilerertivs

NLGDSKALVCRCDSAGKISVVRLSK---DHSPT-------------GYDERMRIQKAGGYVKDGRV---LGVLEVSRSIGDGRFKrCGVISTPDI-MRCT
. .|... ..   .|  .|...  |     ||                ..|.||. ... . .       ..|..|||.||.  | . ||  .|  .   
tasdtevvlssGaiaeglsiinsPkgvgfdspgwmkfnhlynqnnfldeiririeslqaalynygellvnrllkksrskGdknlk.elviPnndspllvv

LTDNDRFLLLACDGLWKGFSVDEAVKYISKILDVRYTyiLTNeepgldpVEARFQLACDRIASDAVRNGSSDNVTVM
   || ||.|| ||||. .| .. |. . ..|  ...    .       .|  |.    .|.  ||. || ||.|..
akanDqflvlatdGlwevlsyqdvveevkellrdkss..qkk.......iewdfneisrviveeavkrgsgDnitlv
subfamily_PPM1K_pd Subfamily PPM1K 144-342 4.3e-32 104.3 In-house 31-228 (263) alignment 
Range on Protein: 144-342
Range on HMM: 31-228/263.0
MAYYAVFDGHAGPRASLFAAEHLHENIKSRMPkgsitgKDKEIKKCLVDAYTLTDEQFLHEASK---GTPVWKDGSTAVSVLVIN-NTLYVANLGDSKAL
. |.||||||||. |  |. ..|.. .|  ..      |.|.... |..|.   |... . .      .   . |.||  .|. . . | .|.||||.|.
llyvavfdGhaGsaaadfvhdklekilkrlle......kekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrai

VCRcdsAGKIsvVRLSKDHSPTGYDERMRIQKAGGYVK-----DGRVLGVLEVSRSIGDGRFKRCGVISTPDIMRCTL-TDNDRFLLLACDGLWKGFSVD
.||    ||    .|..||.|   .|. ||..||| |.       .| |.| ..||.||  .|| |||.||.  .  .  ..| ||.|  ||.    .  
lcr...nGka..kkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsq

EAVKYISKI
|  ..... 
elcdlvrlc
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 146-338 3.3e-23 75.6 In-house 22-223 (292) alignment 
Range on Protein: 146-338
Range on HMM: 22-223/292.0
Y-YAVFDGHA--GPRASLFAAEHLHENIKSRMPKGSITGKdKEIKKCLvDAYTLTDEQFLHEASKGTpvwkdgSTAVSVLVINN-TLYVANLGDSKALVC
.  ||.|||   | . . .|...|  .. . ...   . .   ... | |  .  |. ....  ..|      ...|   | ..  |..||.|||.||. 
flaavldGhGvnGdkvaqlaedtlevelleltrqlqelse.alllril.diaakldkltidaresat......tavvcarvrddralilanvGdsrallg

RCDSAGKISVVRLSKDHSPTGYDERMRIQKAGGYVK-----------DGRV------LGVLEVSRSIGDGRFKRCGVISTPDIMrctlTDNDRFLLLACD
||  . .  .. ||.|| |   ||| ||..|||.|.             ||       | | .||..||  ..  ||.. |..         |  |    
rclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePelq....ihagrqylgrgp

GLWKGFSVDEAVKY
|||   |.   . |
glwtrssiarhiay
PP2C_SIG_SM00331 147-334 4.9e-08 25.8 In-house 33-168 (217) alignment 
Range on Protein: 147-334
Range on HMM: 33-168/217.0
YAVFDGHA-GPRASLFAAEhLHENIKSRMPKGsitgkdKEIKKCLVDAYTLTDEQflheaskgtPVWKDGSTAVSVLVI---NNTLYVANLGDSKALVCR
..|.||.  | .|...... |.. ..  . .|      .|... |  .  . .|.          . |.. ... ....   ...|..||.|||  .. |
lvvaDgmGkGlaAaaassq.lrtalrellseg......eelsqalkrlnraiyee.........keekgmfaTlllalydfssgklsyanaGdsrpyllr

cdSAGKISVVRLskdhsptgydermriqkaggyvKDGRVLGVLEVSRsigdgrfkrcgvistPDIMRCTLTDNDrFLLLACDGLWKGFSVDE
  ... .  .                        . |..||. . ..               .||   .|   | .|||. |||.   | ..
..dgklveilkd......................vegaplGlepevs...............vdirelelekgd.llllytDGltearsekg
subfamily_PPM1H_pd Subfamily PPM1H 183-271 1.3e-12 40.2 In-house 133-212 (404) alignment 
Range on Protein: 183-271
Range on HMM: 133-212/404.0
DKEIKKCLVDAYTLTDEQFLHEASKgtPVWKDGSTAVSVLVINNTLYVANLGDSKALVCRCDSAgkisvVRLSKDHSPTGydERMRIQK
.. ..  | .|..  |||  .| ..     | | ||...||... ||||| |||.|...|.|.      . ||.|. |    || |.|.
eeLviGalesaflemDeqiarerea..yrikGGCtalvalvllgklYvanaGDsRailvrkdei.....iplsadftPet..eRqRlqe
subfamily_PDP_pd Subfamily PDP 184-297 6.6e-17 54.7 In-house 113-241 (398) alignment 
Range on Protein: 184-297
Range on HMM: 113-241/398.0
KEIKKCLVDAYTLTDEQFLHEAS---KGTPVW------KDGSTAVSVLVINNTLYVANLGDSKALVCRCDSAGKISVVRLSKDHSPTGYDERMRIQKAG-
...|. |  |..  |... .||    |.. .         |..|. .|. ...|.||| ||..|.... .  |. ..|.||||.. .  .|  ||.|.  
ekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHP

-----GYVKDGRVLGVLEVSRSIGDGRFK
       ...||.|| |  .|  || |.|
geesktvirngRlLgeLqPlRAFGdvryK
subfamily_PPM1G_pd Subfamily PPM1G 213-344 1.7e-33 109.3 In-house 295-430 (473) alignment 
Range on Protein: 213-344
Range on HMM: 295-430/473.0
KDGSTAVSVLVINNTLYVANLGDSKALVCRCdsaGKisVVRLSKDHSPTGYDERMRIQKAGGYVK-DGRVLGVLEVSRSIGDGRFKRCG-------VIS-
. |.||| .|. ...|.||| |||.. ..|    ||   . || || |    |. ||.|||| |. |||| | | .|| .||  .|.         .|| 
dsGttAvvaLlkekklivAnaGDsRcvlsrn...Gk..AldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisA

TPDIMRCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILD
 |||   |||..| || |||||.|   . .| | .. . | 
lPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklk
subfamily_TAB1_pd Subfamily TAB1 213-329 1.9e-18 59.4 In-house 128-259 (333) alignment 
Range on Protein: 213-329
Range on HMM: 128-259/333.0
KDGSTAVSVLVINNTLYVANLGDSKALVCRCDSagKISVVRLSKDHSPTGYDERMRIQKAG---GYVKDGRVLGVLEVSRSIGDGRFKR-----------
..|.||| .|..|| ||||| |||.||...  .  .  |. ||.||.    || .|... |     .|  ..||  |  ||||| . |            
sgGttAvvalifnnkLyVaNvGdsrAllvkrke..sekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssa

--CGVISTPDIMRC-TLTDNDRFLLLACDGLWKG
    ||..|||     ..|  .||.|  ||. | 
kgePviaePdiqgaypiddityflvlmSdGvykt
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 215-334 1.7e-07 22.8 In-house 135-273 (317) alignment 
Range on Protein: 215-334
Range on HMM: 135-273/317.0
GSTAVSVLVINNTL-YVANLGDSKALVCRCDSAGK-----ISVVRLSKDHSPTGYDERMRIQKA----GGYVKDGrVLGV---------LEVSRSIGDGR
|.|||  .|...|   ||| ||. |||   | ||.     .||  ||. |.    .|| |....    . . .||  | .         | ...|.|  .
GttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedg.ylaildealaayelqltkslGhkl

FKRCGVISTPDIMRCTLTDNDRFLLLAC-DGLWKGFSVDE
.|| |||  |..   .|  .. | .... ||.  ... ..
lkraGviadPevrsrvldvdevfavvvvsdGitdelkrld
subfamily_PP2D1_pd Subfamily PP2D1 222-345 3.7e-21 68.4 In-house 184-308 (492) alignment 
Range on Protein: 222-345
Range on HMM: 184-308/492.0
LVINNTLYVANLGDSKALVCRCdsaGKisVVRLSKDHSPTGYDERMRIQKAGGYV----KDGRVLGVLEVSRS---IGDGRFKRCgVISTPDIMRCTLTD
|..  .||.|| |. .|..||    ||   ..| ..| |    || |..|||. |    | |.| |.|.. |    .||.. |.  ||  | .   .|..
leelgvlyianaGnvqAvLcre...Gk..aiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkks.vipePkttsvklde

NDRFLLLACDGLWKGFSVDEAVKYISKILDV
.. ||.||  |||. .| .| .. . ..| .
aaqflvlAsnGlWevlseeevlsLvkqtlai
subfamily_PHLPP_pd Subfamily PHLPP 227-341 5.3e-13 41.4 In-house 106-214 (246) alignment 
Range on Protein: 227-341
Range on HMM: 106-214/246.0
TLYVANLGDSKALVCRCDSagkisVVRLSKDHSpTGYDERMRIQKAGGYVK-DGRVLGVLEVSRSIGDgRFKRCGVISTPDIMRCTLTDNDRFLLLACDG
.| ||. |  .| ..|  .      .|||| ..    ||  ||..| .... |... ||.| .| .|   |    |. .| .   .||..| .|..  . 
sLevAsvGtlqavliRngk.....klrlsksyv.iekdelkrikeakaiitednkingviestrllGy.tflfPvvlPkphvrevlLteqdellivGnka

LWKGFSVDEAVKYISK
||. .|.||||. . |
lWevlsideaveavrk
subfamily_PDP_pd Subfamily PDP 301-344 8.8e-09 27.9 In-house 270-313 (398) alignment 
Range on Protein: 301-344
Range on HMM: 270-313/398.0
VISTPDIMRCTLTDNDRFLLLACDGLWKGFSVDEAVKYISKILD
....|...   |. ||.||.|| ||||  .| .|.|..... |.
ltaePevtshklrendkFLvlatDGLwdllsneevvslVgehla