Gene PDP-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PDPc
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP138_AA protein Get Run
NvecP138_AA_105-497 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PP2Cc_SM00332 106-494 4.5e-61 199.6 In-house 14-274 (274) alignment 
Range on Protein: 106-494
Range on HMM: 14-274/274.0
YeTNQLASNQPMEDRKFVVRLL-HQDGGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHRHVLLahpdlmpkltdyltitknedhcynyandpacrnsl
. ...  ....|||. .||  | ..... .||| |||||...|  |.|.||.... .|      |                                   
k.ssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel...................................

nkyfyelqdmveahVEMHVRSIREAYIRLDQDIRNEAVKESKSKlpegsschafdaANAGACALVAYIQGTELFLANAGDCRAVLGVQGEdgcwsAMQLS
               ..  . ...|. ..|..|. |. .. . .            |..|..|.||....  |..||.||.||||. .|.     | |||
..............eddveealkkaflstdeeileeeqskelen............alsGstavvallkkedlyvanvGDSravlcrngk.....avqls

SDHTAGNPEEVQRILNQHPpeesttVIRFERLLGRLAPLRAFGDARFKWDKktqnkvysksslnpmsevehFYTPPYLTAEPEVMSYQLQRTDKFLVLAT
 ||.. ...|..|| ....      |....|. | ||  |||||  .|. |                      ..||.||||.|   .|   |.||.||.
vdhkpedederkRikkagg......vvekgrvngglavsrafGdhflkknk....................klkepyitaepdvkvvtltsedeflilaS

DGLWDMLSNEEVVHYVQEHVCKKvedtskgvlpqditfneqeLPCDLNNAASCLVREALGGddhvavsttlsipypdvRMYRDDISVIVV
|||||.|||.||| .|...  |.                      |  .||  |..||.                   ....|.|.|.||
DGlwdvlsnqevvdivrkllakg...................ktndpqeaaelldeeairr.................ggseDniTvvvv
subfamily_PDP_pd Subfamily PDP 107-498 3.6e-160 526.4 In-house 1-398 (398) alignment 
Range on Protein: 107-498
Range on HMM: 1-398/398.0
ETNQLASNQPMEDRKFVVRLLHQDgGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHRHVLLAHPDLMPKLTDYLTITKNEDHCYNYANDPACRNSLNK
..||||||.|.|||.....||... |.||||.|||||.|||..|.|||..|.|.|||...|| .. . ... ...|...|...|......| |...||..
dsnqLasNePiEDrrseakllesn.gvlfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakklslse

YFYELQDMVEAHVEMHVRSIREAYIRLDQDIRNEAVKESksklPEGSSCHAFDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEDGCWSAMQLSSD
. ..||...||.||.. .....|. .||.||..||.|..    .| |...|...| .|||||.|.|.||||..||.|||||||||| |.|.|.|..||.|
lskylqelleaevekvkealkkaFlklDkdistealkkl....kekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskd

HTAGNPEEVQRILNQHPPEESTTVIRFERLLGRLAPLRAFGDARFKWDKKTQNKVYSKSSlNPMSEVEHFYTPPYLTAEPEVMSYQLQRTDKFLVLATDG
.|| |.|||.|| ..|| |||.|||| .||||.|.|||||||.|.||....|.||..|.. ....|.....|||||||||||.|..|...||||||||||
qtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekay.lkvlepkdyktPPYltaePevtshklrendkFLvlatDG

LWDMLSNEEVVHYVQEHVCKKVEDTSKGVLPQDITFN-----EQELPCDL----NNAASCLVREALGGD---DHVAVSTTLSIPYPDVRMYRDDISVIVV
|||.|||||||..|.||..|| |... .| ....|..     ..|  ..|    .|||..|.|.||||.   |. .||..||||.. .|||||||.|.||
LwdllsneevvslVgehlakkkekepvkveeakltlkqvveelkerkrklkredknaAthLirhalggneagdkekvsallsiPeelaRmyRDDitvtVv

FFNW
|||.
ffns
subfamily_TAB1_pd Subfamily TAB1 112-412 1.1e-17 56.8 In-house 9-261 (333) alignment 
Range on Protein: 112-412
Range on HMM: 9-261/333.0
ASNQPMEDRKFVVrlLHQDGGYLFGVMDGHGGNACAHNVCKRLPDyialSLLHrhvllahPDLMPKLTDYLTITKnedhcYNYandpACRNSLNKYFYEL
  ....||. |..    ... .|..| ||. ||  |. | .||.      ||        ..|...|... .        ..     |  .  .|.. ..
kedhevedkvflf..ktendpilyavFdGydGnkaakfveqrLva....elll.......eqltdelaeaevkev.....lkr....afeeverkflesi

QDMVEAHVEMHVRsireayirLDQDIRN-EAVKESKSKLPEGSSCHafDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEdgCWSAMQLSSDHTAG
.|... . ... .        | ... . |. .....|.   .. .  .  . |. |.|| |   .|. ||.|| ||.|  . |       |||.|||  
ddalaekddlqsq........lPegvssyeleeqypekierlqele..eeisgGttAvvalifnnkLyVaNvGdsrAllvkrke..sekvkqLsvdHttd

NPEEVQRILNQHPpeeSTTVIRFERLLGRLAPLRAFGDARFKWDKKtQNKVYSKSSLNPMsevehfytppylTAEPEVMS-YQLQRTDKFLVLATDGLWD
|..|..|. .       .  |.  ..||   . |. || . |   | .....|... .|.             |||..   |... . .||||  ||.  
NedEllRlkdLGl...dieqikrnkrlgskentRsiGdykvkkgyk.dvdilssakgePv............iaePdiqgaypiddityflvlmSdGvyk

MLS
 | 
tLe
0034914 PP2C-like 114-497 2.4e-59 193.5 In-house 32-291 (295) alignment 
Range on Protein: 114-497
Range on HMM: 32-291/295.0
NQPMEDRKFVVRLL--HQDGGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHRHVLLAHPdlmpkltdyltitknedhcynyandpacrnslnkyfyel
. ..||. .||. |  ......|||| ||||| |.|. ....|.....  | . ..|| ..                                       
rksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltls.......................................

qdmveahVEMHVRSIREAYIRLDQDIRNEAVKEsksklpegsschaFDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGedgcwSAMQLSSDHTAGN
        |. ....|.|....|......|...              . |. |..|.||.|.|. |..||.||.||||  .|      ..||. ||.  |
.......ledieealrkaflaadeellelallr.............pelagsGtTavvalirgnklyvanvGDSravllrng.....elvqltvdhkpvn

PEEVQRILNQHPpeesttVIRFERLLGRLAPLRAFGDARFKWDKKTqnkvysksslnpmsevehFYTPPYLTAEPEVMSYQLQ-RTDKFLVLATDGLWDM
..|..|||. ..      .....|..| ||  ||.|| ..|. ..                   ....|...|||.|....|.   |.||.||.|||||.
elererilsagg......avshgrvngvlavtRalGdfdlklllsl..................llleplvsaePdvtvleltledddfllLasDGlwdv

LSNEEVVHYVQEHVCKKVEdtskgvlpqditfneqelpcdLNNAASCLVREALGgddhvavsttlsipypdvRMYRDDISVIVVFFN
|||||.|..|.... |  .                     |..||  ||..||                   |..||.|.|.||..|
lsneeivdivrsllakgld.....................leeaaeeLvdlAla..................rgsrDNiTvvvvrln
0049733 PP2C-like 114-497 4.1e-40 130.6 In-house 15-234 (235) alignment 
Range on Protein: 114-497
Range on HMM: 15-234/235.0
NQPMEDRKFVvrllhqdGGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHrhvlL---Ahpdlmpkltdyltitknedhcynyandpacrnslnkyfye
.. .||. .|       |..||.| ||||| |... . ..|.....  ||.    |                                            
rkvneDavlv.......glllfavaDGhgghaagevasellvetllellle....lllld........................................

lqdmveahvemHVRSIREAYIRLDQDIRNEAVKESksklpegsschafDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEdgcwsAMQLSSDHTAG
            ....|.|. .... ....|...              . |  |..|.||...|  |..||.||.||.|  .|.     ..||. ||.  
...........leealrkaflaaneallelalasp.............elagmgtTavvalldggklyvanvGDsrayllrdgk.....lvqltedhspv

NPEEVQRILNQHPPEesttvirfeRLLGRLAPLRAFGDARFKwdkktqnkvysksslnpmsevehfytppyltaePEVMSYQLQRTDkFLVLATDGLWDM
|..|.|||.. ..           | .|||| .||.||  .|                                 |.|....|.  | ||.||.|||||.
nelerqriitaggav.........rvpgrlaltralGdlllk.................................pdvtvlelepgd.flllasDGlwdv

LSNEEVVHYVQEhvckkveD-TskgvlpqditfneqelpcdlNNAASCLVREALGgddhvavsttlsipypdvRMYRDDISVIVVFFN
||.||.|.....       .                      ..||..||..||                   |  ||.|.|.||...
lsdeeivdllrs.......ldl....................eeaaerlvelala..................rggrDNiTvvvvrld
subfamily_PPM1A_pd Subfamily PPM1A 115-497 1.4e-37 122.6 In-house 24-281 (282) alignment 
Range on Protein: 115-497
Range on HMM: 24-281/282.0
QPMEDRKFVVRLLHQD-GGYLFGVMDGHGGNACAHNVCKRLPDYIALsllhrhvllahpdlmpkltdyltitknedhcynyandpacrnslNKYFYElQD
. |||.  ||  | .  .. .| |.|||.|. .|. | | |.. |                                              .. . | . 
vemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenile............................................eeelke.aa

MVEAHVEMHVRSIREAYIRLDQDIRNEAVKESKS-KLpegsschafdaanaGACALVAYIQGTELFLANAGDCRAVLGVQGedgcwSAMQLSSDHTAGNP
. . . . .   .|.....||..||..  . ... |               |. |... .. ..|..||.||.||||  .|     .|. |..|| . .|
leasekdevkealrqgfLaldeairelstdlktadks..............GsTavtvlvsekhliianlGDsRavlcrng.....kaaflteDHkpsrp

EEVQRIlnqhppEESTTVIRFERLLGRLAPLRAFGDARFKWDKKTQNKvysKSslnpmsEvehfytppyLTAEPEVMSYQLQRTDKFLVLATDGLWDMLS
.| .||      |.    .  .|. | ||  ||.||  .| ... ...   .                 ..|||||.| . .  |.||||| ||.||.||
kEkkRi......eqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkae...eq......l.........vsaepevtsierseeddflvlacDGiwDvls

NEEVVHYVQEHVCKKvEDTSKGvlpqditfneqelpcdlnnaasclvrealggddhvaVSTTLSIPYpdVRMYRDDISVIVVFFN
.||||..|.... .. .. ..                                     ... .   .   .  || .||.||.|.
deevvelvrkrleva.deleev....................................akalvdkal..ekgsrDNlsvlvvlfa
subfamily_PPM1L_pd Subfamily PPM1L 115-352 9.7e-13 41.0 In-house 17-188 (269) alignment 
Range on Protein: 115-352
Range on HMM: 17-188/269.0
QPMEDRKFVVRLLHQD-GGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHRhvllahpdlmpkltdyltitknedhcY-------Nyandpacrnslnk
. ||||  .   .... |  .|.|.|||||.  |. . ..|.. |   |..                                                 
prmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel..........................dadkentep.............

yfyelqdmveahvemhvrsireayIRLDQDIRNEAVKeSKSKLPEGSScHAfdAANAGACALVAYIQGTELFLANAGDCRAVLgvqgEDGCWSAMQLSSD
                        |  .. . .| .     || |    .|     ||. ||.| .|...| .|| || | ||     |    |. || |
........................infsklltdeils.vdekllekak.ra..ediaGttalialvqesdlivanvGdsrGvl....ydkrGkaiplsfd

HTAGNPEEVQRILNQHPPEESTTVirfERLLGRLAPLRAFGDARFK
|   ...| .|| .         |    |. | ||  ||.||  .|
hkpqqvkerkrikkaGGfiafrGv...wrvaGvlatsralGdyplk
subfamily_PPM1G2_pd Subfamily PPM1G2 126-429 1.8e-34 112.0 In-house 46-252 (287) alignment 
Range on Protein: 126-429
Range on HMM: 46-252/287.0
LLHQDGGYLFGVMDGHGGNACAHNVCKRLPDYIALsllhrhvllahpdlmpkltdyltitknedhcynyandpacrnslnkyfyelqdmveahvE-----
.  ..   ||.|.|||||...|. . |.|  .||                                                                  
ksddkslalfavfDGhGGakvakyagkklikkiak...........................................................kksfke

-MHVRSIREAYIRLDQDIRNEavkesksklpegsscHAFDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEdgcwsAMQLSSDHTAGNPEEVQRIL
 .  . ...|....|......               ....  .||. |.|. |. ..|. ||||| |||| ..|.     . .|| ||   . .| .|| 
galeqilkdafletDeellkd...............eklkdesaGstavvvlikeeklyvanaGDsravlsskgn.....vkalsfDhkPqeesekkrii

NqhppeeSTTVIRFERLLGRLAPLRAFGDARFKWDKKtqnkvysksslnpmsevehfyTP---PYLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEV
.      .  .. ..|  | ||  ||.||  ||  .|                     ..      ||.|.|.  .|.  | ||||| ||.||.|.|.||
a......agGfvelnrvngnLalsralgDfefkknvk.....................kkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkev

VHYVQEHVCKKVE
|..|.|.. .. .
vdlvrerlvsgak
subfamily_PPM1H_pd Subfamily PPM1H 131-311 6.8e-11 34.5 In-house 61-205 (404) alignment 
Range on Protein: 131-311
Range on HMM: 61-205/404.0
GGYLFGVMDGHGGNACAHNVCKRLPDYIALSLLHRHVLLAHPDLmpkltdyltitknEDHCYNYANDPACRNSLNKYFyeLQDMVEaHVEMHVRSIREAY
  ..||. |||.|.. |    | |   .   | .   ||.. .              |..    ....   .| .. .   .  .. . |. . .. .|.
playfglfDGhaGsgaalvaskllhkhlkekledvlellleksa.............eeeenteesskespssvseiy..eekeis.keeLviGalesaf

IRLDQDIRNEAVKeskSKlpegsschafdaANAGACALVAYIQGTELFLANAGDCRAVLGVQGEDgcwsaMQLSSDHTAGN
...|. |..|  .    .             . | .|||| .    |..|||||.||.|  ..|      ..||.|.|   
lemDeqiarerea...yr............ikGGCtalvalvllgklYvanaGDsRailvrkdei.....iplsadftPet
subfamily_PPM1D_pd Subfamily PPM1D 133-319 2.5e-13 42.8 In-house 36-165 (309) alignment 
Range on Protein: 133-319
Range on HMM: 36-165/309.0
YLFGVMDGHGGNACAHNVCKRLPDYIALSllhRHVLLAHPDLMpkltdyltitknedhcynyandpacrnslnkyfyelqdmveahvemhVRSIREAYIR
  ..|.|||||.  |. . ..|  .|      ...|  .|. .                                               .. ||||.. 
afvavfDGHGGkeAakfarehlwsvikkq...kkflssepedv...............................................leAireafla

LDQDIRneavkESKSKLPEGSSCHafdAANAGACALVAYIQGTELFLANAGDCRAVLGVQGE-DGCWSAMQLSSDHTAGNPEEVQRIL
. . ..     ..... |.  | .    . ||. | |  |....|..|. || ..||||. . .  . | .| .||   .|||..|| 
theamk.....kkleeWpktksgl...lstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerie
PP2C Protein phosphatase 2C 210-427 6.7e-41 133.5 Pfam-A 47-232 (255) alignment 
Range on Protein: 210-427
Range on HMM: 47-232/255.0
ELQDMVEAHVEMHVRSIREAYIR-LDQDIRNEAVKE-SKSKLPEgSSCHAfDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEDGcwsaMQLSSDH
|.... . |.| .. . .. .   ..... .... .  ...|   |....    . |..|.||.|.|..|..||.||.||||. ....      .|. ||
eaakyarehleeilkeqksflelekvekalrksfladtdeelks.skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedH

TAGNPEEVQRILNQHPPEESttvirFERLLGRLAPLRAFGDARFKWDKktqnkvysksslnpmsevehfytPPYLTAEPEVMSYQLQRTDKFLVLATDGL
.. ...|..|| ...   .      . |. | ||  ||.|| ..| ..                       ... .|||.| | .|.. |.||.||.|||
kpsdedEreRIeeaggsvsn.....ngrvngsLavsRalGdfelkpke.......................eqlvsaePdvtsvklteedefliLasdGl

WDMLSNEEVVHYVQEHVCKK
||.||..|.|. |.... ||
wdvlsdqeavdlvrselskk
PP2C Protein phosphatase 2C 210-427 6.7e-41 133.5 In-house 47-232 (255) alignment 
Range on Protein: 210-427
Range on HMM: 47-232/255.0
ELQDMVEAHVEMHVRSIREAYIR-LDQDIRNEAVKE-SKSKLPEgSSCHAfDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEDGcwsaMQLSSDH
|.... . |.| .. . .. .   ..... .... .  ...|   |....    . |..|.||.|.|..|..||.||.||||. ....      .|. ||
eaakyarehleeilkeqksflelekvekalrksfladtdeelks.skant.epsksGstavvalirgkklyvAnvGDSravLcrkdnak....keltedH

TAGNPEEVQRILNQHPPEESttvirFERLLGRLAPLRAFGDARFKWDKktqnkvysksslnpmsevehfytPPYLTAEPEVMSYQLQRTDKFLVLATDGL
.. ...|..|| ...   .      . |. | ||  ||.|| ..| ..                       ... .|||.| | .|.. |.||.||.|||
kpsdedEreRIeeaggsvsn.....ngrvngsLavsRalGdfelkpke.......................eqlvsaePdvtsvklteedefliLasdGl

WDMLSNEEVVHYVQEHVCKK
||.||..|.|. |.... ||
wdvlsdqeavdlvrselskk
PP2C_SIG_SM00331 211-495 1.5e-08 27.5 In-house 52-216 (217) alignment 
Range on Protein: 211-495
Range on HMM: 52-216/217.0
LQDMVEAHVEMHvRSIREAYIRLDQDIRNEavkesksklpegsscHAFDAANAGACALVAYIQGTELFLANAGDCRAVLGVqgEDGCWSAMQLssdhtag
|..... ... .  .. .|  ||.. |..|               . ..   | .....  ... .| .|||||.| .|    ...     .        
lrtalrellseg.eelsqalkrlnraiyee...............keekgmfaTlllalydfssgklsyanaGdsrpyllr..dgklveilkd.......

npeevqrilnqhppeesttvirferllgrlaplrafgdarfkwdkktqnkvysksslnpmseV-----------EhfytppyltaePEVMSYQLQRtDKF
                                                              |           .           ... . .|.  . .
..............................................................vegaplGlepevs...........vdirelelek.gdl

LVLATDGLWDMLSNE-----EVVHYVQEHVCKKVEDTSKGVLPQDITFNEQELPcdlnnaasclvrealggddhvavsttlsipypdvrmyRDDISVIVV
|.|.||||... | .     .. . ....|.  ... ..  . . ... ...                                       .|||.|.||
lllytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsng.....................................eDdiTvvvv

F
.
k
subfamily_PPM1K_pd Subfamily PPM1K 213-352 3.2e-11 35.9 In-house 47-182 (263) alignment 
Range on Protein: 213-352
Range on HMM: 47-182/263.0
DMVEAHVEMHVRSIREAYIRLdQDIRNEAVKESKSKLPEGSSCHAF--DAANAGACALVAYI-QGTELFLANAGDCRAVLGVQGEdgcwsAMQLSSDHTA
| |  ..| ... . |    | . . ..| .| . ||      .    .  ..|. | |. . .|||| ||. || ||.|  .|.     |..|..||. 
dfvhdklekilkrllekekdl.eivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGk.....akkltrdhdP

GNPEEVQRILNQHPPEESTTViRFERLLGRLAPLRAFGDARFK
   || .||..     |....    .. ||||  |..||  .|
eleeekerikaagGsvewnsl.gkplvngrlamtrslGdldlk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 214-320 8.2e-08 25.1 In-house 40-143 (292) alignment 
Range on Protein: 214-320
Range on HMM: 40-143/292.0
MVEAHVEMHVRSIREAYIRLDQDIRNEAVkESKSKLPEGSSCHAFDAANAGACALVAyiQGTELFLANAGDCRAVLGVQGEDGCWSAMQLSSDHTAGNPE
. | ..|... .       | . . .  . .  .|| .    .   |. |  || |    . .|.||| || ||.||          . || ||   .|.
laedtlevelleltrqlqelsealllril.diaakldkltidaresattavvcarvr..ddralilanvGdsrallgrclggsdyeliPlsrdhkPedPd

EVQRILN
| .|||.
erarilr
PPM_PTC7 225-427 4.4e-39 127.5 In-house 75-237 (259) alignment 
Range on Protein: 225-427
Range on HMM: 75-237/259.0
SIREAYIRLDQDIRNEAvkesksklpegSSCHAfDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEDGcwsaMQLSSDHTAGNPEEVQRILNQHPP
 .|... .||.|....            |....    . |..|.||.|.|..|. ||.||.||||. .|..      ||. ||.. |..|..|| . .  
alrksflaldtdeelks...........seant.epstsGstAvvalitgsklyvAnvGDSravLcrsgnav....kqltedHkpsnedEreRiegaggs

EESTtviRFERLLGRLAPLRAFGDARFKWDKKtqnkvysksslnpmsevehfyTPPYLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQEHV
 ..    .. |. | ||  ||||| ..| ...                     ......|||.. | ...  |.||.||.|||||..|..|.|. |....
vsnv...gngrvngvlavsRafGdfelkpket.....................eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrsel

CKK
 ||
skk
PPM_PTC7_SpoIIE 225-441 4.3e-20 65.5 In-house 72-223 (230) alignment 
Range on Protein: 225-441
Range on HMM: 72-223/230.0
SIREAYIRLDQDIRNEavkesksklpegsschafdAANAGACALVAYIQGTE--LFLANAGDCRAVLGVQgEDGcwsamqlssdhtagnpeEVQRILNQH
 .|... .|..|...|                    .. ||.|.||.|...   | .|||||....|  . ..|                 |. ||    
ilrrlnlalaadlede...................psssgaTavvalidpstgklyvanaGdsppllvrd.dgg.................ererivagg

PPE----ESttvirfeRLLGRLAPLRAFGDARFKWdkktqnkvysksslnpmsevehfyTPPYLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVH
.|.    .        |  | ||  .|.||  ..                         |  . .|||. .   | . |.||.||.|||||.||..|.|.
lpslGilpg.......rvfgvlavslapGdlllly........................tDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvd

YVQEHVCKKvedTSKGVLPQDIT
 |.... |.    ..| |  |||
lvrdelekp...aaeglleDDit
PP2C_2 Protein phosphatase 2C 228-431 3.2e-07 22.8 Pfam-A 82-201 (212) alignment 
Range on Protein: 228-431
Range on HMM: 82-201/212.0
EayirldqdirneavkesksKLPEGSSCHAfDAANAGACALVAYIQGTELFLANAGDCRAVlgVQGEDGCWSAmqLSSDHTAGNPEEVQRILNQHPPEES
.                   .  | .. .. .. . ..  |.| |...|..... ||...|  |...|| . .  |..... .   |....  . . || 
k...................lkqeaeaqqe.elkdyatTlllavitpgeivffqiGDgaiv..vrdrdgevql..lgepdsgeyanettfltsedaeeel

ttvirferllgrlaplrafgdarfkwdkktqnkvysksslnpmsevehfytppyltaepEVMSYQlQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKK
                                                           .. . .  .  . |.| |||..|.|..|| .. . ......
...........................................................rirrlk.lepgdalllmTDGvsdslrkeepfrellaellet

VEDT
.|..
leee
PP2C_2 Protein phosphatase 2C 228-431 3.2e-07 22.8 In-house 82-201 (212) alignment 
Range on Protein: 228-431
Range on HMM: 82-201/212.0
EayirldqdirneavkesksKLPEGSSCHAfDAANAGACALVAYIQGTELFLANAGDCRAVlgVQGEDGCWSAmqLSSDHTAGNPEEVQRILNQHPPEES
.                   .  | .. .. .. . ..  |.| |...|..... ||...|  |...|| . .  |..... .   |....  . . || 
k...................lkqeaeaqqe.elkdyatTlllavitpgeivffqiGDgaiv..vrdrdgevql..lgepdsgeyanettfltsedaeeel

ttvirferllgrlaplrafgdarfkwdkktqnkvysksslnpmsevehfytppyltaepEVMSYQlQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKK
                                                           .. . .  .  . |.| |||..|.|..|| .. . ......
...........................................................rirrlk.lepgdalllmTDGvsdslrkeepfrellaellet

VEDT
.|..
leee
subfamily_PPM1G_pd Subfamily PPM1G 239-430 1.4e-25 83.2 In-house 271-435 (473) alignment 
Range on Protein: 239-430
Range on HMM: 271-435/473.0
NEAVKESKS-KLPEGSSCHAFDAANAGACALVAYIQGTELFLANAGDCRAVLGVQGEdgcwsAMQLSSDHTAGNPEEVQRILNQhppeeSTTVIRFERLL
.| .....  .  .||  .     ..|. | || ... .|. |||||.|.||  .|.     |..|| ||   ...| .|| .        .|    |. 
eedgegeeakeeldgseekeepGedsGttAvvaLlkekklivAnaGDsRcvlsrnGk.....AldlslDHkPeDevEleRiekA.....GGkvdedgRvn

GRLAPLRAFGDARFKWDKKTQNKVYSksslnpmsevehfytppyLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKKVED
| |   ||.||  .| ... ..|                     ..| |..   .|.  |.|||||.||.|.... .||| .|.... |. |.
GGLnlsRAlGDhaYkkneeLplkeqm..................isAlPDikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgees
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 261-349 7.2e-09 28.3 In-house 93-175 (255) alignment 
Range on Protein: 261-349
Range on HMM: 93-175/255.0
ANAGACALVAYIQGTELFLANAGDCRAVLGVQgeDGcwSAMQLSSDHTAGNPEEVQRILNQHPPEESTtvIRFERLLGRLAPLRAFGDA
   |. | ...| .   ..|| || |.||. .  ||   | .|| ||   ...| .|| .      ||      |. | ||  ||.||.
kfiGttaasvliiedkvyianvGdsrvvlcqk..dg..takrlsldhkPseeseekriselGGtvvst..vvtsrvnGtlavsralGds
subfamily_ILKAP_pd Subfamily ILKAP 264-352 1.1e-08 27.6 In-house 114-197 (293) alignment 
Range on Protein: 264-352
Range on HMM: 114-197/293.0
GACALVAYIQGTELFLANAGDCRAVLGVQGEDGC-WSAMQLSSDHTAGNPEEVQRIlnqhppEESTTVIRFERLLGRLAPLRAFGDARFK
|. | |  .    |. || || .|||  . |.|   ....|. |||. . || .||      . . .|.|  |.|| |   |. || |||
GstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkri......qkaGgvvrdgrvlGvlevsrsiGdgrfk
subfamily_PP2D1_pd Subfamily PP2D1 271-320 9.6e-06 17.5 In-house 184-228 (492) alignment 
Range on Protein: 271-320
Range on HMM: 184-228/492.0
YIQGTELFLANAGDCRAVLGVQGedgcwSAMQLSSDHTAGNPEEVQRILN
 .. . |..||||. .|||  .|     .|..|  .|| .|..| .|. .
leelgvlyianaGnvqAvLcreG.....kaiiLtreHtprnkkERtRvek
subfamily_PHLPP_pd Subfamily PHLPP 372-422 2.3e-07 23.0 In-house 164-214 (246) alignment 
Range on Protein: 372-422
Range on HMM: 164-214/246.0
EVEHFYTPPYLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQE
 . .... |..  .|.| . .|.  | .|..  . ||..|| .|.|. |..
llGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavrk
subfamily_PPM1H_pd Subfamily PPM1H 376-428 9.6e-12 37.3 In-house 299-355 (404) alignment 
Range on Protein: 376-428
Range on HMM: 299-355/404.0
FYTPPYLTAEPEVMSYQLQR----TDKFLVLATDGLWDMLSNEEVVHYVQEHVCKKV
 .  |.|...|||. ..|.     .|. |.||||||||.|||||| . |.| . |  
lsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 376-422 3.4e-10 32.6 In-house 175-222 (255) alignment 
Range on Protein: 376-422
Range on HMM: 175-222/255.0
FYTPPYLTAEPEVM-SYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQE
 .  |.....|..  |.. ...||||.|| ||.||..|.|| |. | .
sflePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveivag
subfamily_PPM1E_pd Subfamily PPM1E 380-432 9.2e-13 41.0 In-house 184-236 (265) alignment 
Range on Protein: 380-432
Range on HMM: 184-236/265.0
PYLTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKKVEDTS
||...|..|....|. ....|.||.|||||.. .||||. |.|.. ...||.|
pyvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedls
subfamily_ILKAP_pd Subfamily ILKAP 382-431 2.4e-10 33.1 In-house 201-250 (293) alignment 
Range on Protein: 382-431
Range on HMM: 201-250/293.0
LTAEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKKVEDT
... |.|.  .|.  |.|.||| ||||. .|..|||..... . .. .|.
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddr
subfamily_PPM1L_pd Subfamily PPM1L 383-424 4.4e-11 35.6 In-house 194-236 (269) alignment 
Range on Protein: 383-424
Range on HMM: 194-236/269.0
TAEPEVMSYQLQR-TDKFLVLATDGLWDMLSNEEVVHYVQEHV
 |.|......|.    .||.||.||||| .|||| |....|..
iadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerl
subfamily_PPM1K_pd Subfamily PPM1K 383-443 2.7e-06 19.7 In-house 187-246 (263) alignment 
Range on Protein: 383-443
Range on HMM: 187-246/263.0
TAEPEVMSYQL-QRTDKFLVLATDGLWDMLSNEEVVHYVQehVCKKVEDTSKGVLPQDITFN
 |.||  | ..   .| |||| |||. ......|. ..|.  .|.. |.... .  | . . 
iatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr..lchdpeeaahalteqalqyg
subfamily_PP2D1_pd Subfamily PP2D1 384-438 9e-10 30.8 In-house 266-320 (492) alignment 
Range on Protein: 384-438
Range on HMM: 266-320/492.0
AEPEVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKKVEDTSKGVLPQ
 ||.. | .|. ...|||||. |||..||.|||.  |.. .    . . ....|.
pePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenvpd
subfamily_PPM1D_pd Subfamily PPM1D 384-463 1.7e-09 30.2 In-house 224-287 (309) alignment 
Range on Protein: 384-463
Range on HMM: 224-287/309.0
AEPEVMSYQLQRT-DKFLVLATDGLWDMLSNEEVVHYVQEHVCKKVEDTSKGvlpqditfneqelpcdlNNAASCLVREAL
 ||.|. ..|.   .||..||.||||..|. |..|. |... .||.   ...                 .. |..||.|||
PePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs.................rsvakalvkeal
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 387-422 4.3e-07 22.7 In-house 237-272 (292) alignment 
Range on Protein: 387-422
Range on HMM: 237-272/292.0
EVMSYQLQRTDKFLVLATDGLWDMLSNEEVVHYVQE
  .. .|.. |.|||||.||. |.|.|.||| ....
rklekeldsddaflvlasdGvldvllnaevvlllak
subfamily_PPTC7_pd Subfamily PPTC7 387-432 4.2e-06 19.3 In-house 158-202 (252) alignment 
Range on Protein: 387-432
Range on HMM: 158-202/252.0
EVMSYQLQRTDkFLVLATDGLWDMLSNEEVVHYVQEHVCKKVEDTS
...|..... |  .|||||||.| |...|... ..|  ... ..  
dsksfavkkgD.iivlatDGlfDNlledeileilkelkeseksslq
Subfamily Dicty-PPM1L-like 395-427 2.6e-06 19.5 In-house 234-266 (305) alignment 
Range on Protein: 395-427
Range on HMM: 234-266/305.0
RTDKFLVLATDGLWDMLSNEEVVHYVQEHVCKK
  |.||||||||||..||...||  |.| . .|
anDqflvlatdGlwevlsyqdvveevkellrdk
PPM_PTC7_motif 401-427 3.5e-10 33.2 In-house 1-27 (51) alignment 
Range on Protein: 401-427
Range on HMM: 1-27/51.0
VLATDGLWDMLSNEEVVHYVQEHVCKK
.||.|||||.||..|.|. |.....||
iLAsDGLWDvlsdqeavdlvrdqlskk