Gene PPM1A in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP142_AA protein Get Run
NvecP142_AA_3-296 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 4-296 6.6e-87 283.8 In-house 3-292 (295) alignment 
Range on Protein: 4-296
Range on HMM: 3-292/295.0
FLDKPRTEKETKTGEGNGLRYGLAAMQGWRVEMEDAHTAVIGLSDHLKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEaaikESSDSPDLDQLRS
.|..| .|. . . . . ||.| | .||.| ..|||...|..|  .|.|...|.||||| | ......|..|.|.||..          .....|.....
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekl....lllltlslediee

GLRDAFLELDSTMQKLPKWSSGEDKSGSTAIALLVTPKYYIFANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVMIQRVNGALAVSRALGD
 ||.|||..|  . .|  ...  . ||.||...|........||.|||| .|..|||... |||||| |..|. ||..||| |.  |||| |||.|||||
alrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGd

FEYKLDSSLHATKQLVSPEPDIFFQSRS-DQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITDDLQRVSCELLDTCLTKGSRDNMSVIIISLPG
|..||  ||.....|||.|||....... ..|.|..||.||.|||..|.|. ..|||.|. ..||. .. ||.| .| .|||||..|... |.|
fdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlng
subfamily_PPM1G_pd Subfamily PPM1G 4-117 2.6e-27 89.0 In-house 1-100 (473) alignment 
Range on Protein: 4-117
Range on HMM: 1-100/473.0
FLDKPRTEKETKTGEGNGLRYGLAAMQGWRVEMEDAHTAVIGLSdhlKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAaikessdspdlDQLRS
.|.||..|||....  ..|.|| .|||||||..||||.... |    .|.|.|||.||| |..|.||....| . | .......           .....
ylskpkvekesedesneelsygasamqGwrvsqEDahncitdld...edtslfavyDGHGGkevakyvakklpdllkaqkgyke...........gdvek

GLRDAFLELDSTMQ
.|..|||.||....
aleeaflalDeklk
subfamily_PPM1G2_pd Subfamily PPM1G2 5-294 8.9e-86 280.4 In-house 2-286 (287) alignment 
Range on Protein: 5-294
Range on HMM: 2-286/287.0
LDKPRTEKETKTGEGNGLRYGLAAMQGWRVEMEDAHTA---VIGLSDHlKDWSFFAVFDGHAGENVSKYCSSNLHETLLKhqsfeaaikesS---DspdL
|..| ..||..... .  . | .||||.|..|||||.    .. .||. |. ..||||||| |..|.||....|.... |               .    
lsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksdd.kslalfavfDGhGGakvakyagkklikkiak...........kksfk...e

DQLRSGLRDAFLELDSTMQKLPKwsSGEDKSGSTAIALLVTPKYYIFANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVMIQRVNGALAVS
..|.  |.|||||.|. ..|  |    ....||||.. |.. .  . ||.|||| .||..|.|   ..|||| . .||.||..||| | ..||||.||.|
galeqilkdafletDeellkdek..lkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLals

RALGDFEYKLDSSLHATKQLVSPEPDIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITDDLQRVSCELLDTCLTKGSR------DNMSVIII
|||||||.|  .....  |.|  .||.  ......|||.||||||.|||.||.||  .||.||.   .|.... ||||.||.. |.      |||.|.|.
ralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvviv

SL
.|
vl
subfamily_PPM1A_pd Subfamily PPM1A 13-295 9.1e-122 398.8 In-house 3-281 (282) alignment 
Range on Protein: 13-295
Range on HMM: 3-281/282.0
ETKTGEGNGLRYGLAAMQGWRVEMEDAHTAVIGLSdHLKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAaikESSDSPDLDQLRSGLRDAFLEL
 ....||||||||...|||||||||||||.|. |. .|||||||||||||||..|.||....|.|..|.......   ..... . |.....||..||.|
pksqaegnglrygvssmqgwrvemEDahtvvaslg.alkdwsfFavfDGHaGsevakyvkkhllenileeeelke...aaleasekdevkealrqgfLal

DSTMQKLPKWSSGEDKSGSTAIALLVTPKYYIFANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVMIQRVNGALAVSRALGDFEYKLDSSL
|.....| ......|||||||...||..|..|.||.||||..|..||.....| |||| .|.||.|||.|||||...||||||||||||||.||| ....
deairelstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeek

HATKQLVSPEPDIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITDDLQRVSCELLDTCLTKGSRDNMSVIIISLP
.|..||||.||... ..||..|.|.||||||.|||....|| ..||.||...|.|..|. .|.|..|.||||||.||... ..
kaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlfa
PP2Cc_SM00332 15-292 2.9e-80 262.6 In-house 3-274 (274) alignment 
Range on Protein: 15-292
Range on HMM: 3-274/274.0
KTGEGNGLRYGLAAMQGWRVEMEDAHTAVIGLSdHLKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAAIKessdspdLDQLRSGLRDAFLELDS
..|...||.||...|||||..|||||  |. |. . .||.||.|||||.|..|.|..|..|.| | .. ....  .        |.    |..|||..|.
esgsnlglsygkssmqgwrksmeDahvvvvdlv.eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdel.......eddveealkkaflstde

TMQKL-PKWSSGEDKSGSTAIALLVTPKYYIFANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVMIQRVNGALAVSRALGDFEYKLDSslH
 . .   ..   . .|||||.  |.. .  ..||.|||| .|. ||...  .||||| ..||. ||..|||.|. .|||| ||||||.||...|  .   
eileeeqskelenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..k

ATKQLVSPEPDIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRL--QITDDLQRVSCELLDTCLTK-GSRDNMSVIII
 ... ...|||.   .  ..|||..||.||.|||..|.||  .||..|  . | | |... .| . .. . ||.||..|...
lkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 21-295 3.1e-46 150.7 In-house 5-254 (255) alignment 
Range on Protein: 21-295
Range on HMM: 5-254/255.0
GLRYGLAAMQGWRVEMEDAHTAvIGLSDHLKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSfeaaIKESsdSPdLDQlrsgLRDAFLELDSTMQKLP
 .. | . | | |  |||  ..  |   . .|  ..|.||||.|.. .|..| .|.  | .       ....  .| ..     |..|. |..  ... |
rfkvgfsdmiGrrptmedelvi.yGsfrdksdedyyalfdGhgGraaakfaseelykilaelld....lnna..nP.vks....lkkaykeistqiserp

kwssgeDKSGSTAIALLVTPKYYIFANCGDSRGILS-HNGEVIYNTVDHKPGNPDEKTRIENAGGSVMIQ----RVNGALAVSRALGDfeykldSSLhat
         |.||...|.. .... || |||| .|. ..|     ..|||| ...|. ||...|| |. .    |||| |||||||||      | |   
......kfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGd......sfl...

KQLVSPEPDIF-FQSRSDQDEFIVLACDGVWDVMTNDEVGAFVrsrLQITdDLQRVSCELLDTCLTKGSRDNMSVIIISLP
.  | |.||.      | .|.|..|||||.||.....|    |   ..|. | .. . .| |   ..|| ||.|||.| |.
ePfvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiv...agis.dpekaaeklrdlayssGstdnisvivikls
0049733 PP2C-like 22-294 2.3e-60 196.7 In-house 3-233 (235) alignment 
Range on Protein: 22-294
Range on HMM: 3-233/235.0
LRYGLAAMQGW-RVEMEDAHTAviglsdhlkDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFeaaikessdsPDLDQLRSGLRDAFLELDSTMQKLP
|..| | ..|. | ..|||. .         ....|||.||| | ......|..|.||||..             ..| .|.  ||.|||.... . .| 
lsvgaasdigrvrkvneDavlv.........glllfavaDGhgghaagevasellvetllellle..........lllldleealrkaflaaneallela

KWSSGEDKSGSTAIALLVTPKYYIFANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVmiqRVNGALAVSRALGDFEYKldsslhatkqlvs
. | . . .|.||...|........||.|||| .| ..|.... |.||.| |..|. ||..||| |   ||.| ||..|||||...|             
laspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk.............

pePDIFFQSRSDQDeFIVLACDGVWDVMTNDEVGAFVRSrlqitDDLQRVSCELLDTCLTKGSRDNMSVIIISL
  ||...   ...| |..||.||.|||....|. ...||     .||. .  .|....|..|.|||..|... |
..pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggrDNiTvvvvrl
PPM_PTC7 23-287 2.1e-78 256.4 In-house 2-259 (259) alignment 
Range on Protein: 23-287
Range on HMM: 2-259/259.0
RYGLAAMQGWRVEMEDAHTAVIGLS--DHLKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAAIkessdspdldQLRSGLRDAFLE--LDSTMQK
..|  |.||.|..|||||.|  .|.  .. ....||||||||.|  ..||....|.| | . .|||              |  .||..||.  .|... .
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele..........klekalrksflaldtdeelks

lPKWSSGEDKSGSTAIALLVTPKYYIFANCGDSRGILSHNGEVI-YNTVDHKPGNPDEKTRIENAGGSVM---IQRVNGALAVSRALGDFEYKLDSSlha
 .. ......|||||. .|.|..  ..||.|||| .|. .|...   |.|||| |.||. |||.|||||.    .|||| ||||||.||||.| . .   
.seantepstsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...

TKQLVSPEPDIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITdDLQRVSCELLDTCLTKGSRDNM
..||||.||||    ....|||..||.||.|||....|.  .|||.|. . |..... .|.|... .||.||.
eeqlvsaePdisstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedni
PP2C Protein phosphatase 2C 23-287 2.8e-78 256.0 Pfam-A 2-255 (255) alignment 
Range on Protein: 23-287
Range on HMM: 2-255/255.0
RYGLAAMQGWRVEMEDAHTAVIGL--SDHLKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAAIkessdspdldQLRSGLRDAFLE-LDSTMQKL
..|  ..||.| .|||||.|   |  |.. ....||||||||.|. ..||....|.| | . .||. .           ... .||..||. .|..... 
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..........kvekalrksfladtdeelkss

PKWSsGEDKSGSTAIALLVTPKYYIFANCGDSRGILSHNGEVI-YNTVDHKPGNPDEKTRIENAGGSVM-IQRVNGALAVSRALGDFEYKLDSslhatKQ
 . .  ..||||||.  |...|  ..||.|||| .|. ... .   |.|||| ..||. |||.|||||. ..|||| |||||||||||.| ..     .|
kant.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eq

LVSPEPDIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITDDLQRVSCELLDTCLTKGSRDNM
|||.|||.   .....|||..||.||.|||....|.  .|||.|. ........ ||.| .. .||.||.
lvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 23-287 2.8e-78 256.0 In-house 2-255 (255) alignment 
Range on Protein: 23-287
Range on HMM: 2-255/255.0
RYGLAAMQGWRVEMEDAHTAVIGL--SDHLKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAAIkessdspdldQLRSGLRDAFLE-LDSTMQKL
..|  ..||.| .|||||.|   |  |.. ....||||||||.|. ..||....|.| | . .||. .           ... .||..||. .|..... 
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..........kvekalrksfladtdeelkss

PKWSsGEDKSGSTAIALLVTPKYYIFANCGDSRGILSHNGEVI-YNTVDHKPGNPDEKTRIENAGGSVM-IQRVNGALAVSRALGDFEYKLDSslhatKQ
 . .  ..||||||.  |...|  ..||.|||| .|. ... .   |.|||| ..||. |||.|||||. ..|||| |||||||||||.| ..     .|
kant.epsksGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eq

LVSPEPDIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITDDLQRVSCELLDTCLTKGSRDNM
|||.|||.   .....|||..||.||.|||....|.  .|||.|. ........ ||.| .. .||.||.
lvsaePdvtsvklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PPM_PTC7_SpoIIE 23-275 2.3e-39 128.6 In-house 2-218 (230) alignment 
Range on Protein: 23-275
Range on HMM: 2-218/230.0
RYGLAAMQGWRVEMEDAHTAVIGLS--DHLKDWSFFAVFDGHAGENvsKYCSSNLHeTLLKHQSFEAAIkessdspdldQLRSGLRDAFLELDSTMQKLp
..|  |.||.| .|||||..  ..   ..   . .....||| |    ..... |. |.|. ..|. .           ..   ||...|.|.  ...  
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllr.talrelafagle..........kpeeilrrlnlalaadlede.

kwssgEDKSGSTAIALLVTPKY--YIFANCGDSRGILSHNGEViyntvdhkpgnpdEKTRIeNAGGSVM----IQRVNGALAVSRALGDFEYKLdsslha
     ...||.||. .|..|      .||.|||. .|.....              |..||  ||| ..     .||.| ||||.| ||. ..       
.....psssgaTavvalidpstgklyvanaGdsppllvrddgg.............ereri.vagglpslGilpgrvfgvlavslapGdlllly......

TKQLVSPEPDiFFQSRSDQ-DEFIVLACDGVWDVMTNDEVGAFVRSRLQITddlqrVSCELL
| ..|..|||   . . .. |||..||.||.|||....|.  .||..|        .. .||
tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaegll
Subfamily Dicty-PPM1L-like 23-131 2.5e-09 29.4 In-house 8-112 (305) alignment 
Range on Protein: 23-131
Range on HMM: 8-112/305.0
RYGLAAMQGWRVEMEDAHTAVIGLSDHlKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAaIKESSDSPDLDQLR-SGLRDAFLELDSTMQklpK
.|.| . .. |   || .   |.| .  .. |.| ||||| |.  ..|   .| | . |.      .  |..  . |.|    ...|.|. |. .    .
kyelyvsansrkyqedrnkvkisless.qelslfGvfdGhnGdiaaeyvkkklveivnkyvkenk.vGysaknlnvddlpleaiksaslstdkssl...d

WSSGEDKSGS
 .....| . 
saesdnkkaG
subfamily_PPM1K_pd Subfamily PPM1K 25-294 5.7e-37 120.3 In-house 7-258 (263) alignment 
Range on Protein: 25-294
Range on HMM: 7-258/263.0
GLAAMQGWRVEMEDAhTAVIGLSDhlkDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSfeaaiKESsdspDLDQLrsgLRDAFLELDSTMQKLPKWS-
| ....| | | ||    .  |..   .  ..||||||||    ... ..|...| .        ||     ||...   |..||.|||  ...  ..| 
GkdsliGkraenedr.iklkeldp...ellyvavfdGhaGsaaadfvhdklekilkrlle.....kek....dleiv...lknafeeldkklkrylefsv

--SGEDKSGSTA-IALLVTPKYYIFANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVMI-----QRVNGALAVSRALGDFEYKLDSsLHAT
  . . .||.|| ..||   .  . |. |||| ||  ||.    | ||.|   .|| || .|||||        .||| ||..|.|||.. |    . ||
aeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG.viat

kqlvsPEPDIfFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRsrlqITDDLQRVSCELLDTCLTKGSRDNMSVIIISL
     ||    .. . ..| |.||  ||. .|... |.. .||    .  | .. .  | .. |  || || ..... |
.....Petks.lkvdhaadsflvlitdgisfvvnsqelcdlvr....lchdpeeaahalteqalqygsednatavvvpl
subfamily_PPM1E_pd Subfamily PPM1E 26-294 3.5e-54 176.8 In-house 8-262 (265) alignment 
Range on Protein: 26-294
Range on HMM: 8-262/265.0
LAAMQGWRVEMEDAHTAVIGLSDHLK-----DWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAAIKessdspdldqlrSGLRDAFLELDSTMQKlp
.||... |  ||| | |.  |   ..     . .||||||||.| . .|| ...|||.| ......   .            . |..|| ..|... .  
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa............ealkeafkltDerflq..

KWSSGEDKSGSTAIALLVTPKYYIFANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVMI---QRVNGALAVSRALGDFEYkldsslhatKQ
|  . . ||||||.. |.. .    |  |||...| ..||..  .  ||| ..||| |||.||| |.     |||| |.||||.|| ..         |.
kaereklksGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvkl.........kp

LVSPEPDIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITD-DLQRVSCELLDTCLTKGSRDNMSVIIISL
 || |.|.   .  ...|...|||||.|||....||   |.. |. .  ||..|. .|...   .||.||..|... |
yvsgeadvaeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_ILKAP_pd Subfamily ILKAP 26-268 1.7e-42 138.6 In-house 9-250 (293) alignment 
Range on Protein: 26-268
Range on HMM: 9-250/293.0
LAAMQGWRVEMEDAHTAVIGLS-------DHLKDWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAAIKESsdspdlDQLRSGLRDAFLELDSTMQK
 |  .| | ||.|||. .  |.       ....  |..||||||||.  |......||...|.. . .   ..        ...  | |.| . |. . |
yaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsake......keikkclvdsfkktdeefLk

LPKWSSGEDKSGSTAIALLVTPKYYIFANCGDSRGILSH---NGE---VIYNTVDHKPGNPDEKTRIENAGGSVMIQRVNGALAVSRALGDFEYKldssl
| . .    | ||||. .||  .    || |||. .|     .|.   ..  |.||.| . .|. ||. |||.|   ||.| | |||..|| ..|     
laskakPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfk.....

hatKQLVSPEPDIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITDDLQ
   .  |.  ||.     .. | |.||||||.|.|...|||  |. . |.  .| .
...rlGvistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddr
subfamily_PPM1D_pd Subfamily PPM1D 27-189 1.5e-27 89.5 In-house 7-174 (309) alignment 
Range on Protein: 27-189
Range on HMM: 7-174/309.0
AAMQGWRVEMEDAHTAVIGLSDHLK--DWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFeaaikESSDSPDLdqlRSGLRDAFLELDSTMQK-LPKWS
.| || |  |||  . |.  .....  ...|.|||||| |.. .|. ...| ... |.. |      ||...|.   .. .|.|||.. ..|.| | .|.
eadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkf.....lssepedv...leAireaflatheamkkkleeWp

SGEDK----SGSTAIALLVTPKYYIFANCGDSRGILSHNGE------VIYNTVDHKPGNPDEKTRIENAGGSVMIQ
  ...    .|.||  .... .    |. |||. .|. . .          |.|||| .|.||.|||..||.|...
ktksgllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak
subfamily_PPM1L_pd Subfamily PPM1L 28-294 2.8e-44 144.4 In-house 11-266 (269) alignment 
Range on Protein: 28-294
Range on HMM: 11-266/269.0
AMQGWRVEMEDAHTAVIGLSDHLKdWSFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEAAIKESSDSPDLDQLrsgLRDAFLELDSTMqkLPKWSSGED
...| | .|||  .   ..... .  ||||||||| ||  .... . | ......    .| || .   . ..|   | |  | .|  .  | |  . ||
svlGrrprmedrfeieediknktg.esffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfskl...ltdeilsvdekl..lekakraed

KSGSTAIALLVTPKYYIFANCGDSRGILS-HNGEVIYNTVDHKPGNPDEKTRIENAGGSVMI---QRVNGALAVSRALGDFEYKldsslhaTKQLVSPEP
 .|.||.  ||. .  | || |||||.|  ..|. |  . |||| .. |. ||..||| . .    ||.| ||.||||||.  |        |.|| ..|
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.......dknlviadp

DIF-FQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITDdLQRVSceLLDTCLTKGSRDNMSVIIISL
||. |.    . ||..||.||.|| ..|.|   |.. ||.  | .   |  |   .  .|| ||..|... |
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepd.fGaks..lvlesfkrGsvdnitvlvvkl
subfamily_KAPP-like_pd Subfamily KAPP-like 31-294 8.4e-30 96.7 In-house 7-266 (266) alignment 
Range on Protein: 31-294
Range on HMM: 7-266/266.0
GWRVEMEDAHTAVIGLSDHLK-----DWSFFAVFDGHAGENVSKYCSSNLHETLLKHqsFEAAIKESSDSPDLDQlRSGLRDAFLELDSTMQKLpkwssg
|  .|||| . |.  | .. |     . ..|||||||||  ...  .  . . | |.   . . ..    .  || .  |..|| |.|. ...       
gcstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekl..lkstkqddGGdniydq.skllenafkevdaklkdf......

eDKSGSTAIALLV----TPKYYIFANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVM--IQRVNGaLAVSRALGDFEYKLDSSLHATKQLV
 .  |.||   ||      .|   || |||  .||.  | .. . |||  .|.|| || . | ..     |.|| |||||||||   |      ...  |
.eyeGatatlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyv

SPEPDIffqsrSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITDDLQRVSCELLDTCLT-KGSRDNMSVIIISL
|..  .     . .|.|...| ||.|||.. ..    |.|  .  .  ....  ||.| .    ..||.|||.. |
snrill.....tpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 31-294 3.1e-28 91.4 In-house 6-276 (276) alignment 
Range on Protein: 31-294
Range on HMM: 6-276/276.0
GWRVEMEDAHTAVIGLSDHLK-----DWSFFAVFDGHAGENVSKYCSSNLHETLLKHQ-SFEAAIKESSDSPD-LDQLRSGLRDAFLELDSTMQKLpkws
|  .|||| . |.  | |. .     . ..|||||||||  ...  .  . . |.|   | . .. .  |  |   . .  | |.| |.|. ...     
gcstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdf....

sgeDKSGSTAIALLV----------TPKYYIFANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVM--IQRVNGaLAVSRALGDFEYKLDSS
   .  |.||   ||            .|   || |||  .||.  | .. . |||  .|.|| || . | ..     |.|| |||||||||   |    
...eyeGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelni

LHATKQLVSPEPDIffqsrSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITDDLQRVSCELLDTCLT-KGSRDNMSVIIISL
  ...  ||..  .     . .|.|...| ||.|||.. ..    |.|  .  .  ....  ||.| .    ..||.|||.. |
Glisepyvsnrill.....tpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvkl
subfamily_PP2D1_pd Subfamily PP2D1 32-83 4.1e-08 25.3 In-house 13-64 (492) alignment 
Range on Protein: 32-83
Range on HMM: 13-64/492.0
WRVEMEDAHTAVIGLSDHLkDWSFFAVFDGHAGENVSKYCSSNLHETLLKH-Q
|. .|||..| .    ..  . .||...||. |    . ....||| ||.. .
WKskmeDkrtlqdyfgndv.nscFfgiyDGynGataAeiaakelhevlleele
PP2C_2 Protein phosphatase 2C 48-262 6.8e-08 25.1 Pfam-A 19-196 (212) alignment 
Range on Protein: 48-262
Range on HMM: 19-196/212.0
DHLKDWSFFAVFDGHAGENVSKYCSSNLHETLlkHQSFEAAIKESSDSPdLDQLRSGLRDAFLE-LDSTMQKLPKWSsGEDKSGSTAIALLVTPKYYIFA
 . .|....|| ||.   . |.  .  . |..   ...|. ..|.| .   ..|.  .. . |. ..   ..  ...   .. ..| .....||.. .|.
reasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqe.eeallrqieneilasvklkqeaeaqqe.elkdyatTlllavitpgeivff

NCGDSRG-ILSHNGEVIYNTVDHKPGNPDEKTRIENA--GGSVmiqrvngalavsralgdfeykldsslhatkqlvspepdIFFQSRSDQDEFIVLACDG
..||..  . ...|||   . ... .   | |..  .  ....                                       . . . .. . ..|  ||
qiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel......................................rirrlklepgdalllmTDG

VWDVMT-NDEVGAFVRSRLQ
|.| .. .... .... .|.
vsdslrkeepfrellaelle
PP2C_2 Protein phosphatase 2C 48-262 6.8e-08 25.1 In-house 19-196 (212) alignment 
Range on Protein: 48-262
Range on HMM: 19-196/212.0
DHLKDWSFFAVFDGHAGENVSKYCSSNLHETLlkHQSFEAAIKESSDSPdLDQLRSGLRDAFLE-LDSTMQKLPKWSsGEDKSGSTAIALLVTPKYYIFA
 . .|....|| ||.   . |.  .  . |..   ...|. ..|.| .   ..|.  .. . |. ..   ..  ...   .. ..| .....||.. .|.
reasdgwllaVADGaGsakrSdkGarlaveaa..gealeklleeeseqe.eeallrqieneilasvklkqeaeaqqe.elkdyatTlllavitpgeivff

NCGDSRG-ILSHNGEVIYNTVDHKPGNPDEKTRIENA--GGSVmiqrvngalavsralgdfeykldsslhatkqlvspepdIFFQSRSDQDEFIVLACDG
..||..  . ...|||   . ... .   | |..  .  ....                                       . . . .. . ..|  ||
qiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel......................................rirrlklepgdalllmTDG

VWDVMT-NDEVGAFVRSRLQ
|.| .. .... .... .|.
vsdslrkeepfrellaelle
subfamily_PPM1H_pd Subfamily PPM1H 52-82 6.4e-06 18.2 In-house 61-91 (404) alignment 
Range on Protein: 52-82
Range on HMM: 61-91/404.0
DWSFFAVFDGHAGENVSKYCSSNLHETLLKH
.  .|..||||||. ..  .| .||..| ..
playfglfDGhaGsgaalvaskllhkhlkek
PP2C_SIG_SM00331 54-293 4.2e-14 45.6 In-house 31-216 (217) alignment 
Range on Protein: 54-293
Range on HMM: 31-216/217.0
SFFAVFDGHAGENVSKYCSSNLHETLLKHQSFEaaikessdspdldqlrSGLRDAFLELDSTMQKLpkwsSGEDKSGSTAIALLV--TPKYYIFANCGDS
 ...|.||. .   .  .|| |.. | .. | .                . | .|. .|.. ....    ..|. .. |....|.  . .   .||.|||
lllvvaDgmGkGlaAaaassqlrtalrellseg................eelsqalkrlnraiyee....keekgmfaTlllalydfssgklsyanaGds

RGILSHNGEVIYNTVDhkpgnpdektrienaggsvmiqrvngalavsralgdfeykldsslhATKQLVSPEPDIF---FQSRSDQDEFIVLACDGVWDVM
| .| ..|. .. . |                                               . .... ||..     .   .......|. ||.....
rpyllrdgklveilkd..............................................vegaplGlepevsvdirelelekgdllllytDGltear

-----TNDEVGAFVRSRLqiTDDLQRVSC----ELLDTCLTKGSRDNMSVIIIS
      ....  .... .  .. .|...     ||| .   .. .|...|... 
sekgfaeerleeiledlv..dseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 55-205 3.6e-15 49.2 In-house 22-184 (292) alignment 
Range on Protein: 55-205
Range on HMM: 22-184/292.0
F-FAVFDGHA--GENVSKYCSSNLHETLLkhqsfeaaikESsdSPDLDQLRSGLRDAFLeldSTMQKLPKWSSGEDKSGSTAIALLVTPKY--YIFANCG
|  ||.|||   |..|...  ..|   ||          |.   ..| .|   |    |   ..  || |    . .|..||.   ...     | || |
flaavldGhGvnGdkvaqlaedtlevell..........el..trqlqelsealllril...diaakldkltidaresattavvcarvrddralilanvG

DSRGILSH-----NGEVIYNTVDHKPGNPDEKTRIENAGGSVM-----------IQRV------NGALAVSRALGDFE
||| .|       . |.|  . |||| .|||. || .||| |              ||      .| ||.||||||| 
dsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfh
subfamily_PDP_pd Subfamily PDP 98-280 1.8e-20 66.4 In-house 112-331 (398) alignment 
Range on Protein: 98-280
Range on HMM: 112-331/398.0
LDQLRSGLRDAFLELDSTM-----QKLPKWSSGE----DKSGSTAIALLVTPKYYIFANCGDSRGILSH---NG--EVIYNTVDHKPGNPDEKTRIENAG
...... |. |||.||. .     .||.. |. |      ||..|.. |. ..    || ||.| .|     .|  |..  . |.   |..| .||... 
vekvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeH

---G---SVMIQRVNGALAVSRALGDFEYKLDSSLHA---TK---QLVSP-----------EPDIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSR
        .. .|. | |. .|| ||..||... |.    .|   . . |           ||... .  . .| |.||| || ||...|.||   |   
PgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgeh

LQITDDLQRVSCELLDTCLT
|. ... . |. |  .. |.
lakkkekepvkveeakltlk
subfamily_PPM1H_pd Subfamily PPM1H 104-179 4.3e-08 25.3 In-house 139-210 (404) alignment 
Range on Protein: 104-179
Range on HMM: 139-210/404.0
GLRDAFLELDSTMQKlpKWSSGEDKSGSTAI-ALLVTPKYYIfANCGDSRGILSHNGEVIYNTVDHKPGNpdEKTRI
 | .||||.|. ...    .. ..| | ||. ||... | |. || |||| ||....|.|    |. |    |. |.
alesaflemDeqiar..ereayrikGGCtalvalvllgklYv.anaGDsRailvrkdeiiplsadftPet..eRqRl
subfamily_PPM1G_pd Subfamily PPM1G 125-294 8.5e-53 173.0 In-house 293-470 (473) alignment 
Range on Protein: 125-294
Range on HMM: 293-470/473.0
GEDkSGSTAIALLVTPKYYIFANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVM-IQRVNGALAVSRALGDFEYKLDSSLHATKQLVSPEP
||| ||.||.  |.  |  | || |||| .||.||. .   .|||| .. |..|||.||| |    |||| | .||||||. || ...| .  |..|  |
Ged.sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlP

DIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITD--DLQRVSCELLDTCLTKGS------RDNMSVIIISL
||  .   ..|||.||||||.|.||. .||  |||..|. ..   |...  ||||.||..         |||.|||..|
DikvltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
subfamily_PP2D1_pd Subfamily PP2D1 126-265 3e-22 72.0 In-house 174-310 (492) alignment 
Range on Protein: 126-265
Range on HMM: 174-310/492.0
EDKSGSTAIALLVTPKYYIfANCGDSRGILSHNGEVIYNTVDHKPGNPDEKTRIENAGGSVM----IQRVNGALAVSRALGDFEyklDSSLhatKQLVSP
|..| .. . | ..   || || |. . .| ..|. |  | .| |.|. |.||.|.||..|.      .|||.| . | || .    |  |   |. | |
ekesngsevhleelgvlyi.anaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG...dpkL...kksvip

EPDIFFQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITD
|| .      ... |.|||  |.|.|....|| . |.. |.|  
ePkttsvkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyk
subfamily_TAB1_pd Subfamily TAB1 129-249 2.3e-10 32.8 In-house 129-261 (333) alignment 
Range on Protein: 129-249
Range on HMM: 129-261/333.0
SGSTAIALLVTPKYYIFANCGDSRGILSH---NGEVIYNTVDHKPGNPDEKTRIENAGGS-VMIQR--VNGALAVSRALGDFEYK-----LDSSLHATKQ
 |.||.  |.  .    ||.|||| .| .   . .|    |||.  |.|| .|... |     |.|  . |     |..||.. |      |   .|...
gGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdilssakge

LVSPEPDIFFQSR-SDQDEFIVLACDGVWDVMT
 |  ||||       |   |.||  |||   . 
PviaePdiqgaypiddityflvlmSdGvyktLe
subfamily_PHLPP_pd Subfamily PHLPP 146-293 1.2e-06 20.6 In-house 110-244 (246) alignment 
Range on Protein: 146-293
Range on HMM: 110-244/246.0
ANCGDSRGILSHNGEVIYNTVDHKpGNPDEKTRIENAGGSVMI-QRVNGALAVSRALGDFeykldsSLHatkQLVSPEPDIFFQSRSDQDEFIVLACDGV
|. |    .|  ||. .  .  ..  . ||  || .| . .   ...|| .. .| || .      .|.     | |.| .     ..|||....  . .
AsvGtlqavliRngkklrlsksyv.iekdelkrikeakaiitednkingviestrllGyt......flf...PvvlPkphvrevlLteqdellivGnkal

WDVMTNDEVGAFVRSRlqiTDDLqRVSCELLDTCLTKGSRDNMSVIIIS
|.|.  ||.   ||      | |  .   | |     | .|..||... 
Wevlsideaveavrke...edpl.vaAkklvdlaqsygaadsvsvlvvr
Subfamily Dicty-PPM1L-like 175-294 7.9e-12 37.6 In-house 182-303 (305) alignment 
Range on Protein: 175-294
Range on HMM: 182-303/305.0
EKTRIENAGGSVMI---QRVNGALAVSRALGDfeykldsslHATKQLVSPEPDIFFQ-SRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITDDLQ--
.. ||| ......     .||. | .||  ||           .|.|| |..|         .|.|.||| ||.|.|. ...|  .|.  |...   .  
iririeslqaalynygellvnrllkksrskGd.........knlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkki

-----RVSCELLDTCLTKGSRDNMSVIIISL
      .|       . .||.||. ..|| |
ewdfneisrviveeavkrgsgDnitlviikl
subfamily_PPM1H_pd Subfamily PPM1H 189-265 1.6e-13 43.2 In-house 275-355 (404) alignment 
Range on Protein: 189-265
Range on HMM: 275-355/404.0
QRVNGALAVSRALGDFEYKLDSSLHATKQLVSPEPDIF----FQSRSDQDEFIVLACDGVWDVMTNDEVGAFVRSRLQITD
.|. . ..|.| ||| | |  ..    | ..||.|..      |  |..|. ..|| ||.|||..|.||.. ||. |. ..
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskve
subfamily_PPM1D_pd Subfamily PPM1D 195-294 3e-14 45.8 In-house 201-307 (309) alignment 
Range on Protein: 195-294
Range on HMM: 201-307/309.0
LAVSRALGDFeYKLdsSLHATKQLVSPEPDIFFQSRSDQ-DEFIVLACDGVWDVMTNDEVGAFVRSRLQITDD----LQRVSCELLDTCLTKGSR-----
|||.|.|||. .    . .  . .||||||.  . .  . ..||.|| ||.|.|.| ...  .|..  ...       . |.  |... | . ..     
LavaRslGDl.Wsy..naksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNMSVIIISL
||.|||.. |
Dnvsvivvil
PPM_PTC7_SpoIIE_motif 235-293 3.9e-08 26.9 In-house 13-79 (81) alignment 
Range on Protein: 235-293
Range on HMM: 13-79/81.0
EFIVLACDGVWD-------VMTNDEVGAFVRSRlqITDDLQRVSCELLDTCLTKG---SRDNMSVIIIS
. ..|..||...       .....|. ......     .||... .|.|..|  |   ..|....... 
dvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevlengsgereDDitllvlr
PPM_PTC7_motif 238-287 1.2e-14 47.5 In-house 1-51 (51) alignment 
Range on Protein: 238-287
Range on HMM: 1-51/51.0
VLACDGVWDVMTNDEVGAFVRSRLQI-TDDLQRVSCELLDTCLTKGSRDNM
.||.||.|||....|.  .||..|    ...|... .| |..| .|| ||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni
PP2C_C Protein serine/threonine phosphatase 2C, C-terminal domain 288-358 8.8e-23 69.9 Pfam-A 1-71 (81) alignment 
Range on Protein: 288-358
Range on HMM: 1-71/81.0
SVIIISLPGSPKVTDEAIKNEQKVEAELEAKLEALLEEETNLAEVDVSYAMQSLSQEEIQGLPPGGGLASK
|.|.. .|| |||..||.|.|.. .. ||.. | ..|....  . |. . ...|..|.| .||||||||||
siilvcfpgAPkvseeAvkkeaeLdkalesrveeiieksseeevpdllsvlktlasedipnLPPGGglasK