Gene PPM1D in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1D
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP143_AA protein Get Run
NvecP143_AA_1-309 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1D_pd Subfamily PPM1D 2-308 5.4e-140 458.8 In-house 3-308 (309) alignment
Range on Protein: 2-308
Range on HMM: 3-308/309.0
RVSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDPEHVVKAIKEGFMATHRSMWKVLENWPKTRH
.|.|||.|||||.|||...| ............||.||||||||.||| |||..||..||||..|.||.||.|..||.|.|.|||..|.|.||.||||..
svtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktks

GLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTKRLEAYPLTDDHKPEAPHEKRRIEDLGGSVLARNGVYRVAWERPVCHgHRGPmrrsTKTER
||.||.|||..|.|||..|..|||||||..||..|||..|.|.| .||.|||||.|.||.|||.|||.| |..||.||.|.|| .. |.||    |....
gllstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprle.hngp....tvide

VPFLAVSRSLGDLWSFDYFRGEFVVSPVPDVKVYTINPATDKHVILASDGLWGVVQPDDAVRCVMWYSCVNTWH----PSYLPRLVSKALSRWRARKLRA
.|||||.||||||||.....|||||||.|||||.|..|...|..|||||||| |..|.|||..|..........     |. ..||..||.|||..||||
iPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklra

DNTSVIVVSFE
||.||||| .|
Dnvsvivvile

0034914 PP2C-like 2-309 1.9e-58 190.6 In-house 22-292 (295) alignment
Range on Protein: 2-309
Range on HMM: 22-292/295.0
RVSSEAHQGGRKCMEDFTSILFDRQHIGKdiGQAFIAVFDGHGGREAAVFARSRLWETIKKQ----RGFYSSDPEHVVKAIKEGFMATHRSMWKVLENwp
||..  .|| || .||. .....  .  .  ......||||||| .|| .|...|.|.....      ......| ...|....|.|... ... ...  
rvgvasdqGrrksneDavlvvlnllslle..dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall..

ktrHGLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEpgtkrlEAYPLTDDHKPEAPHEKRRIEDLGGSVLArngV--Yrvawerpvchghrgpmrr
   .   ..||||..|..|||.|..||.|||| ||| ..       |...|| ||||  . |..||...|| |        .                  
...rpelagsGtTavvalirgnklyvanvGDSravllrng......elvqltvdhkpvnelererilsaggavsh...grvn..................

stktervPFLAVSRSLGDLWSF---DYFRGEFVVSPVPDVKVYTINPATDKHVILASDGLWGVVQPDDAVRCVMWYSCVNTWHPSYLPRLVSKALSrwra
       ..|||.|.||| . .    ..  |..||..|||.|.....  |. ..|||||||.|. ....|..|. .   ..       .||  ||.    
.......gvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla....

rKLRADNTSVIVVSFED
 .   ||..|.|| ...
.rgsrDNiTvvvvrlng

subfamily_PPM1A_pd Subfamily PPM1A 2-308 9.7e-45 146.1 In-house 13-281 (282) alignment
Range on Protein: 2-308
Range on HMM: 13-281/282.0
RVSSEAHQGGRKCMEDFTSILfdrQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGF-----YSSDPEHVVKAIKEGFMATHRSMWKVLENW
|.. .. || |..|||  ..    ...|.  ...| ||||||.|.|.| .. . | |.| ..  .      .|. ..| .|...||.|.. .. .  .. 
rygvssmqgwrvemEDahtvv...aslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdl

PKTrhglpSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEpgtkrlEAYPLTDDHKPEAPHEKRRIEDLGGSVLarngVYRVAWErpvchghrgpmrrs
 ..       ||.|....... .....|..||| |||....      .|  ||.||||. |.||.|||. ||||.    | ||                 
kta.....dksGsTavtvlvsekhliianlGDsRavlcrng......kaaflteDHkpsrpkEkkRieqAGGsvv....vsRvnGa..............

tktervpfLAVSRSLGDLwSFDY----FRGEFVVSPVPDVKVYTINPATDkHVILASDGLWGVVQPDDAVRCVMWYSCVNTWHPSYLPRLVSKALsrwra
        |||||.|||  ...        |  ||..|.|..  ..   | ...||.||.| |.. ...|  |     |..   .   .|| |||     
........LAvsRalGDy.eykeeeekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkal.....

RKLRADNTSVIVVSFE
.|   || ||.|| |.
ekgsrDNlsvlvvlfa

subfamily_PPM1G2_pd Subfamily PPM1G2 2-171 8.9e-28 90.0 In-house 20-173 (287) alignment
Range on Protein: 2-171
Range on HMM: 20-173/287.0
RVSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYssdPEHVVKAIKEGFMATHRSMWKVlenwpktRH
.|.| | || |  |||   .  .  .   |   |..||||||||...| .| ..| ..|.|.. |     ... ...|..|..| ... |        ..
kvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfk...egaleqilkdafletDeellkd.......ek

GLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPgTKRLeayplTDDHKPEAPHEKRRIEDLGGSVL
   ...|.| .|..|. .|..|| .||| |||.||   .| |     . ||||.  .||.||.. || | 
lkdesaGstavvvlikeeklyvanaGDsravlsskgn.vkal.....sfDhkPqeesekkriiaagGfve

PPM_PTC7 3-300 1.8e-66 217.3 In-house 3-259 (259) alignment
Range on Protein: 3-300
Range on HMM: 3-259/259.0
VSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDpeHVVKAIKEGFMATHRSMWKVLenwPKTRHg
....| || ||.|||   .|.. .  ....  || |||||||||||| .||..|.| .|... |....   . ||....|.| .  ... .   ..... 
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele..klekalrksflaldtdeelks...seant.

LPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTkrleaYPLTDDHKPEAPHEKRRIEDLGGSVLARnGVYRVAWErpvchghrgpmrrstkterv
.|||||.| .|..|.|.|..||.||||.|||....         .|| ||||. . |..|||..||||    |. || .                     
epstsGstAvvalitgsklyvAnvGDSravLcrsgnav.....kqltedHkpsnedEreRiegaggsvsnv.gngrvngv....................

pfLAVSRSLGDLWSFDYFRGEFVVSPVPDVKVYTINPAtDKHVILASDGLWGVVQPDDAVRCVmwYSCVNTWhpsyLPRLVSKALSRWRARKLRADNT
  |||||..||.........|..||. ||... .|..  |...|||||||| || ...||  |   |... .     |. ....| ... .. ..||.
..lavsRafGdfelkpketeeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlv..rselskk....dpmeaaeklvdeaiargsedni

PP2C Protein phosphatase 2C 3-300 8.3e-65 211.9 Pfam-A 3-255 (255) alignment
Range on Protein: 3-300
Range on HMM: 3-255/255.0
VSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDpeHVVKAIKEGFMAtHRSMWKVLenwPKTRHg
|.... || ||.|||   .| . .  ....  ||.|||||||||||| .||..|.| .|.|. |....   | ||....|.| . .... .   .|... 
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.

LPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTkrleaYPLTDDHKPEAPHEKRRIEDLGGSVLArngVYRVAWErpvchghrgpmrrstkterv
.||.||.| .|..|||.|..||.|||| |||..|           || ||||. . |..|||..||||     . || .                     
epsksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsn...ngrvngs....................

pfLAVSRSLGDLWSFDYFrgEFVVSPVPDVKVYTINPAtDKHVILASDGLWGVVQPDDAVRCVMwySCVNTWHpsyLPRLVSKALSRWRARKLRADNT
  |||||.|||.......  |..||. |||.. ....  |. .|||||||| |.....||  |   |... ..    |. ....| ... .. ..||.
..LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvr..selskkk...spmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 3-300 8.3e-65 211.9 In-house 3-255 (255) alignment
Range on Protein: 3-300
Range on HMM: 3-255/255.0
VSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDpeHVVKAIKEGFMAtHRSMWKVLenwPKTRHg
|.... || ||.|||   .| . .  ....  ||.|||||||||||| .||..|.| .|.|. |....   | ||....|.| . .... .   .|... 
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele..kvekalrksfla.dtdeelks...skant.

LPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTkrleaYPLTDDHKPEAPHEKRRIEDLGGSVLArngVYRVAWErpvchghrgpmrrstkterv
.||.||.| .|..|||.|..||.|||| |||..|           || ||||. . |..|||..||||     . || .                     
epsksGstavvalirgkklyvAnvGDSravLcrkdnak.....keltedHkpsdedEreRIeeaggsvsn...ngrvngs....................

pfLAVSRSLGDLWSFDYFrgEFVVSPVPDVKVYTINPAtDKHVILASDGLWGVVQPDDAVRCVMwySCVNTWHpsyLPRLVSKALSRWRARKLRADNT
  |||||.|||.......  |..||. |||.. ....  |. .|||||||| |.....||  |   |... ..    |. ....| ... .. ..||.
..LavsRalGdfelkpke..eqlvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvr..selskkk...spmeaaeelvdeaiargsedni

0049733 PP2C-like 3-308 1.4e-43 141.9 In-house 5-234 (235) alignment
Range on Protein: 3-308
Range on HMM: 5-234/235.0
VSSEAHQGG-RKCMEDFTSIlfdrqhigkdiGQAFIAVFDGHGGREAAVFARSRLWETIKKQrgFYSSDPEHVVKAIKEGFMATHRSMWKVLENWPktrh
|.   ..|  || .||.  .           |....||.||||| .|. .|...|.||....  ... .......|... |.|... ...  ...|    
vgaasdigrvrkvneDavlv...........glllfavaDGhgghaagevasellvetllel..llelllldleealrkaflaaneallelalasp....

gLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEpgtkrlEAYPLTDDHKPEAPHEKRRIEDLGGSVlarngvyrvawerpvchghrgpmrrstktER
   ...|||..|....|.|..||.|||| |.| ...      ....|| ||.|  . |..||...|| |                               
.elagmgtTavvalldggklyvanvGDsrayllrdg......klvqltedhspvnelerqriitaggav.............................rv

VPFLAVSRSLGDLWSFdyfrgefvvspvPDVKVYTINPATdkHVILASDGLWGVVQPDDAVRCVMWyscvnTWHPSYLPRLVSKALSRWRArklraDNTS
 . ||..|.||||.              ||| |....|     ..|||||||.|. ....|....      .    .  |||. ||.|.       ||..
pgrlaltralGdlllk............pdvtvlelepgd..flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelalarggr.....DNiT

VIVVSFE
|.|| ..
vvvvrld

PPM_PTC7_SpoIIE 3-265 7.7e-35 113.8 In-house 3-205 (230) alignment
Range on Protein: 3-265
Range on HMM: 3-205/230.0
VSSEAHQGGRKCMEDFTSILFDRQHIGKDIGQAFIAVFDGHGGREaaVFARSRLWETIKKQRgFYSSDpeHVVKAIKEGFMATHRSMWKVlenwpktrhg
... | || ||.|||   .... .  ...   ......||||||.   .|...|........ | ...   . ....... | .. ...           
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle..kpeeilrrlnlalaadlede..........

lPSTSGTTVTVIIIRGHK--MFVAHVGDSGAVLASKEPGtkrleaypltddhkpeaphEKRRIeDLGGSV-L-ARNGvyRVAWErpvchghrgpmrrstk
 ||.||.|..|..|....  . ||..||| ..| ....|                   |..|| ..|| . | ...|  ||...                
.psssgaTavvalidpstgklyvanaGdsppllvrddgg...................ereri.vagglpslGilpg..rvfgv................

tervpfLAVSRSLGDLWSFDyfrGEFVVSPVPDvKVYTINPATDKHVILASDGLWGVVQPDDAVRCV
      ||||.. |||. ..    ..||.. ||  . .. .  |...|||||||| |. |...|. |
......lavslapGdlllly...tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlv

subfamily_PPM1E_pd Subfamily PPM1E 3-179 1.2e-31 102.8 In-house 6-167 (265) alignment
Range on Protein: 3-179
Range on HMM: 6-167/265.0
VSSEAHQGGRKCMEDFTSILFD-RQHIG--KDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFySSDPEhvvKAIKEGFMATHRSMWKvlenwPKT
||..| .. |. |||   .| |  . ..  ..  .|| |||||||| ||| .| ..|.|.. .|  .  .||.   .|.||.| .| ... .       .
vsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqekl.kedpa...ealkeafkltDerflq.....kae

RHGLpsTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKepgtkrLEAYPLTDDHKPEAPHEKRRIEDLGGSVLARnGVYRV
| .|  .||.|  |..|......|| .||| |.| .|       ||  |.. |||| . ||.|||..|| |.   |..||
rekl..ksGstavvvliekdqlyvaWlGDsqallvrk......geavqlmkpHkPeredEkkRieeagGlvvvi.gawRv

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 4-272 5.3e-35 113.9 In-house 9-227 (255) alignment
Range on Protein: 4-272
Range on HMM: 9-227/255.0
SSEAHQGGRKCMEDFTSILFDRQhigKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDPEhvvKAIKEGFMATHRSMwkvlenwpktrHGL
.     | |  ||| ..|    .   .. .. ..|.|||||||.|| ||  .|   ...    ....|.   |..|. . ...  .              
gfsdmiGrrptmedelviyGsfr...dksdedyyalfdGhgGraaakfaseelykilaelldlnnanPv...kslkkaykeistqi...........ser

PSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTKRLeayplTDDHKPEAPHEKRRIEDLGGSVLARngvyrvawerpvchghrgpmrrsTKTERVP
|   ||| ....| ..|...| |||| .||. |.  .|||     . ||||  ..|..||..||| |..                        ..| || 
pkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrl.....sldhkPseeseekriselGGtvvst.......................vvtsrvn

-FLAVSRSLGDLwsfdyFRGEFVVsPVPDVKVYTINPATDKHVILASDGLWGVVQPDDAVRCVMWYSCVN
  |||||.|||      |   ||| | ||..    .  .||..||| ||.| ..  ..||  |.  |  .
GtlavsralGds.....flePfvv.pdPdlsqsleiskkdkflilacdGiwdlisdeeaveivagisdpe

subfamily_PPM1L_pd Subfamily PPM1L 4-180 1.7e-24 79.6 In-house 8-173 (269) alignment
Range on Protein: 4-180
Range on HMM: 8-173/269.0
SSEAHQGGRKCMEDFTSILfdrQHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDPEHVV-----KAIKEGFMATHRSMWKVLENwpk
.  . .| |. |||   |    ..| ...|. |.||||||||  || ||...| ..||..   . .| |. .     | ...  ..  . . .....   
avysvlGrrprmedrfeie...ediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakr...

TRhglpSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEpGtkrlEAYPLTDDHKPEAPHEKRRIEDLGGsVLARNGVYRVA
.      ..|||. . ....... || ||||  ||  |. |    .| ||. ||||. ..|..||.. ||  .| .||.|||
ae....diaGttalialvqesdlivanvGdsrGvlydkr.G....kaiplsfdhkpqqvkerkrikkaGG.fiafrGvwrva

subfamily_PPM1G_pd Subfamily PPM1G 4-89 3.7e-11 35.7 In-house 22-99 (473) alignment
Range on Protein: 4-89
Range on HMM: 22-99/473.0
SSEAHQGGRKCMEDFTSILFDRQHigkdiGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSDpehVVKAIKEGFMATHRSM
.  | || |. .||    . | ..       .. ||.|||||.| |..  ..| . .|.|.|.   |   | ||..| |.|  ...
gasamqGwrvsqEDahncitdlde.....dtslfavyDGHGGkevakyvakklpdllkaqkgykegd...vekaleeaflalDekl

PP2Cc_SM00332 6-305 5.9e-52 169.7 In-house 15-274 (274) alignment
Range on Protein: 6-305
Range on HMM: 15-274/274.0
EAHQGGRKCMEDFTSILFDRQhigKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQRGFYSSD-PEHVVKAIKEGFMATHRSMWKVLENWPKTRhglp
 . || || |||.. . .| .   .  . .|..||||||| |.| |....|.| .|..  . ...  . | .|.|..| .|.  ...  ... . .    
ssmqgwrksmeDahvvvvdlv...eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen....

STSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPgtkrleAYPLTDDHKPEAPHEKRRIEDLGGsvlarngvyrvawerpvchghrgpmrrSTKTERVPF
..||.|..|..... ...||.|||| |||....       | .|. ||||| . |..||.. ||                           ... .||  
alsGstavvallkkedlyvanvGDSravlcrngk......avqlsvdhkpedederkRikkagg...........................vvekgrvng

-LAVSRSLGDLWSFD-YFRGEFVVSPVPDVKVYTInPATDKHVILASDGLWGVVQPDDAVRCVMWYS--CvntwhPSYLPRLVSKALSRWRAR-KLRADN
 |||||..|| .  .     | .... ||||| |.    |. .|||||||| |. ....| .|..              |  ... | .  .| .  .||
glavsrafGdhflkknkklkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakg.....ktndpqeaaelldeeairrggseDn

TSVIVV
..|.||
iTvvvv

subfamily_ILKAP_pd Subfamily ILKAP 8-171 6e-22 71.1 In-house 12-177 (293) alignment
Range on Protein: 8-171
Range on HMM: 12-177/293.0
HQGGRKCMEDFTSILFDRQ---HIGKD--IGQAFIAVFDGHGGREAAVFARSRLWETIKKQrgFYSSDPEHVVKAIKEGFMATHRSMWKvlENWPKTRHG
 .| |. |.| . || | .   .  |.     .. ||||||.|. |. || ..| ..|...  . .||     | ||  .. ...   .  |   . ...
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkilek..lpksdvsakekeikkclvdsfkktde..efLklaska

LPS-TSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTKRLEAYPLTDDHKPEAPHEKRRIEDLGGSVL
 |.   |.|.||...    ..|| .||| |||. |.. .... . .|| ||.|    |..||.  ||.| 
kPvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvr

PP2C_2 Protein phosphatase 2C 8-257 4.1e-09 29.0 Pfam-A 5-182 (212) alignment
Range on Protein: 8-257
Range on HMM: 5-182/212.0
HQGGRKCMEDFTSilfdrqhIGKDIGQAFIAVFDGHGGREA----AVFARSRLWETIKKQRGFYSSD-PEHVVKAIKEGFMATHRsmwkvLENWPKTRHG
|. ..|. .| .        | .. .  ..|| ||.| ..     | .| . . |...|.    | .  |.....|...  |. .     |..  . .. 
hrrkgkpcqDala.......ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk.....lkqeaeaqqe

LPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASkepgtKRLEAYPLTDDHKPEAPHEKRRIEDL--GGSVlarngvyrvawerpvchghrgpmrrstkte
 ..  .||... .|..........||...|. .     .  |. .|..... |.  | ... .   ....                              
elkdyatTlllavitpgeivffqiGDgaivvrd.....rdgevqllgepdsgeyanettfltsedaeeel..............................

rvpflavsrslgdlwsfdyfrgefvvspvpdvKVYTINPATDKHVILASDGLWGVVQ
                                .. ...    ....| .||..  ..
................................rirrlklepgdalllmTDGvsdslr

PP2C_2 Protein phosphatase 2C 8-257 4.1e-09 29.0 In-house 5-182 (212) alignment
Range on Protein: 8-257
Range on HMM: 5-182/212.0
HQGGRKCMEDFTSilfdrqhIGKDIGQAFIAVFDGHGGREA----AVFARSRLWETIKKQRGFYSSD-PEHVVKAIKEGFMATHRsmwkvLENWPKTRHG
|. ..|. .| .        | .. .  ..|| ||.| ..     | .| . . |...|.    | .  |.....|...  |. .     |..  . .. 
hrrkgkpcqDala.......ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk.....lkqeaeaqqe

LPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASkepgtKRLEAYPLTDDHKPEAPHEKRRIEDL--GGSVlarngvyrvawerpvchghrgpmrrstkte
 ..  .||... .|..........||...|. .     .  |. .|..... |.  | ... .   ....                              
elkdyatTlllavitpgeivffqiGDgaivvrd.....rdgevqllgepdsgeyanettfltsedaeeel..............................

rvpflavsrslgdlwsfdyfrgefvvspvpdvKVYTINPATDKHVILASDGLWGVVQ
                                .. ...    ....| .||..  ..
................................rirrlklepgdalllmTDGvsdslr

subfamily_KAPP-like_pd Subfamily KAPP-like 26-170 1.4e-10 33.7 In-house 26-161 (266) alignment
Range on Protein: 26-170
Range on HMM: 26-161/266.0
QHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKQrgFYSSDPEHVVKAIKEGFMATHRsMWKVLENWPKTrHGLpSTSGTTVTVIIIRGHKMFVA-
... .    |..|||||| |. ||. |.  . . ..|.    |.. ..  . | .     .  . | ...  |  .     . .|....   |.. ..  
kklsncsnialfavfdGhaGkGaadaakklfpkelekl..lkstkqddGGdniydqskllen.afkevdaklkd.fey.eGatatlalvwsdGqqrylqv

-HVGDSGAVLASkepGTkrlEAYPLTDDHKPEAPHEKRRIEDLGGSV
  |||| | |.    |    |.  |. ||| . |.||.|| | | ..
anvGdssaflsr...Gn...eslelskdhkakdpeekqrikddGitl

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 26-170 2.4e-08 26.2 In-house 25-171 (276) alignment
Range on Protein: 26-170
Range on HMM: 25-171/276.0
QHIGKDIGQAFIAVFDGHGGREAAVFARSRLWETIKKqrgFYSSDPEHVVKaIKEGFMATHrSMWKVLENWPKT-RHGLP--STSGTTVTVII--IRG--
... .    |..|||||| |. ||. |.  . . ..|   .  |    . |  ..|    .  . |.| .  |     |      |.| |. .    |  
kdlsncsnialfavfdGhaGkGaadaakklfpkelek...llksgnysltk.qddGGdniy.dqskllldlfkevdaklkdfeyeGatatlalvwsdGee

----HKMF--VAHVGDSGAVLASkepGTkrlEAYPLTDDHKPEAPHEKRRIEDLGGSV
    .. .  || |||| | |.    |    |.  |. ||| . |.||.|| | | ..
qqqqqqrylqvanvGdssaflsr...Gn...eslelskdhkatdpeekqrikddGitl

PP2C_SIG_SM00331 33-260 6.4e-10 31.9 In-house 29-168 (217) alignment
Range on Protein: 33-260
Range on HMM: 29-168/217.0
GQAFIAVFDGHG-GREAAVFARS--RLWETIKKQRGFYSSDPEHVVKAIKEGfmathrsmwkvlenwpktrhGLPSTSGTTVTVIII--RGHKMFVAHVG
|. ...|.||.| | .||.....   . ... ...   |. .... .||.|                        . ...|......  ...|. .|..|
grlllvvaDgmGkGlaAaaassqlrtalrellsegeelsqalkrlnraiyee....................keekgmfaTlllalydfssgklsyanaG

DSGAVLASKEPGTKRLEAypltddhkpeaphekrriedlggsvlarngvyrvawerpvchghrgpmrrstktervpflAVSRSLGDLWSFDyfrgefvvs
||  .|  ..  ...|..                                                              .. ||  ....         
dsrpyllrdgklveilkd............................................................vegaplGlepevs.........

pvpdVKVYTINPATDKHVILASDGLWGVVQPDD
    |......   .  ..|..|||. ......
....vdirelelekgdllllytDGltearsekg

Subfamily Dicty-PPM1L-like 34-135 2.1e-06 19.8 In-house 37-143 (305) alignment
Range on Protein: 34-135
Range on HMM: 37-143/305.0
QAFIAVFDGHGGREAAVFARSRLWET----IKKQRGFYSSDPEHV----VKAIKEGFMATHRSMWKVLENWPKTrHGLpSTSGTTVTViIIRGHKMFVAH
. .  |||||.|  || ... .| |     .|. .  ||..   |    ..|||.....| .|. .  |   |   |  .  |.. .| |.   .. |. 
lslfGvfdGhnGdiaaeyvkkklveivnkyvkenkvGysaknlnvddlpleaiksaslstdkssldsaesdnkk.aGt.tlngssasv.ilerertivst

VGDSGAVLAS
 .|. .||.|
asdtevvlss

subfamily_PPM1K_pd Subfamily PPM1K 35-171 7.3e-19 60.9 In-house 32-157 (263) alignment
Range on Protein: 35-171
Range on HMM: 32-157/263.0
AFIAVFDGHGGREAAVFARSRLWETIKKQRgfysSDPEHVVKAIKEGFMATHRSMWKVLENW-PKTrhgLPSTSGTTVTVIIIR-GHKMFVAHVGDSGAV
 ..||||||.|  || |. ..| ...|.         . . . .|. |   .. . . ||   ...      .|||| || ..| | .. .| .||| |.
lyvavfdGhaGsaaadfvhdklekilkrll....ekekdleivlknafeeldkklkrylefsvaea...ellssGttatvsllrdGtelvlaslGdsrai

LASKEpgtkrlEAYPLTDDHKPEAPHEKRRIEDLGGSVL
|  .       .|  ||.||.||  .||.||   |||| 
lcrnG......kakkltrdhdPeleeekerikaagGsve

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 36-216 7.7e-21 67.9 In-house 22-185 (292) alignment
Range on Protein: 36-216
Range on HMM: 22-185/292.0
F-IAVFDGHG--GREAAVFARSRLWETIKKQRGFYSSDPEHVVKAIKeGFMAThrsmWKVLenwpKTRHGLpsTSGTTVTVIIIRGH-KMFVAHVGDSGA
|  ||.||||  |.. | .| ..|   . .        .| ... |     |     .. |       ...   ..|.|.  ..|   ....|.|||| |
flaavldGhGvnGdkvaqlaedtlevelleltrqlqelsealllril.diaak....ldkl....tidare..sattavvcarvrddralilanvGdsra

VLASKePGTKRLEAYPLTDDHKPEAPHEKRRIEDLGGSVLARngvyRVawerpVCHGHRGPMRRSTKTERVPFLAVSRSLGDLWS
.|     |  . |  ||. ||||| | |..||   || |       ||       .|.||. |   . ..   ||.||.|||.  
llgrc.lggsdyeliPlsrdhkPedPderarilraGGrvept....rv.....rgwgfrGtarvwrrrqqeGdlalsralGdfhl

subfamily_PDP_pd Subfamily PDP 100-164 2.8e-10 32.9 In-house 144-208 (398) alignment
Range on Protein: 100-164
Range on HMM: 144-208/398.0
R-HGLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGTKrLEAYPLTDDHKPEAPHEKRRIE
| . |...||.. ..  |.|....|| .||. |||...|. ..  || .|. |.  . ..| .||.
reallvalsGacallaliegtelhvAntGDcravlgvqeeegs.weavkLskdqtadneeEveRik

subfamily_PP2D1_pd Subfamily PP2D1 101-175 2.3e-07 22.9 In-house 171-238 (492) alignment
Range on Protein: 101-175
Range on HMM: 171-238/492.0
HGLPSTSGTTVTViIIRGHKMFVAHVGDSGAVLASKepGtkrlEAYPLTDDHKPEAPHEKRRIEDLGGSVLARNG
.||   | ..     .    ...|..|. .|||  .  |    .|. || .| |. ..|..|.|  |..| . . 
eGlekesngsevh.leelgvlyianaGnvqAvLcre..G....kaiiLtreHtprnkkERtRvekagsvvvksek

subfamily_PPM1H_pd Subfamily PPM1H 101-166 4.4e-06 18.7 In-house 156-213 (404) alignment
Range on Protein: 101-166
Range on HMM: 156-213/404.0
HGLPSTSGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPGtkrleaYPLTDDHKPEAphEKRRIEDL
.    . | |. | ..   |..||  ||| |.|  |.         ||  |. ||.  |..|.  |
eayrikGGCtalvalvllgklYvanaGDsRailvrkdei......iplsadftPet..eRqRlqel

subfamily_PPM1G_pd Subfamily PPM1G 105-170 4.2e-14 45.4 In-house 294-353 (473) alignment
Range on Protein: 105-170
Range on HMM: 294-353/473.0
STSGTTVTVIIIRGHKMFVAHVGDSGAVLASKepgtkrLEAYPLTDDHKPEAPHEKRRIEDLGGSV
. |||| .|......|..|| .||| .||...       .|  |  ||||| ..|..|||  || |
edsGttAvvaLlkekklivAnaGDsRcvlsrn......GkAldlslDHkPeDevEleRiekAGGkv

subfamily_TAB1_pd Subfamily TAB1 107-167 3.3e-08 25.7 In-house 129-186 (333) alignment
Range on Protein: 107-167
Range on HMM: 129-186/333.0
SGTTVTVIIIRGHKMFVAHVGDSGAVLASKEPgtkRLEAYPLTDDHKPEAPHEKRRIEDLG
 |||  |..|   |..|| |||| |.|  ...     .   |  ||. . ..|  |..|||
gGttAvvalifnnkLyVaNvGdsrAllvkrke...sekvkqLsvdHttdNedEllRlkdLG

subfamily_KAPP-like_pd Subfamily KAPP-like 199-306 8.9e-10 31.0 In-house 165-265 (266) alignment
Range on Protein: 199-306
Range on HMM: 165-265/266.0
TERVPFLAVSRSLGDLWSFDYFRGefvVSPVPDVK-VYTINPaTDKHVILASDGLWGVVQPDDAVRCVMW-YSCVNTwHPSYLPRLVSKALSRWRARklr
  |.  |||||.||| .  .   |   ..  | |   ... |  ||..|.|||||| |.. .||.  |   |   .| . .    |.  |.   .|.   
qtrinGlavsralGdhfikelniG...lisepyvsnrilltp.fdkflivasdGlwdvisGkdaiekvkslydqqat.edkmasslletaiqsikak...

aDNTSVIVVS
 || ||||| 
.dnvsvivvk

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 199-306 9e-10 30.9 In-house 175-275 (276) alignment
Range on Protein: 199-306
Range on HMM: 175-275/276.0
TERVPFLAVSRSLGDLWSFDYFRGefvVSPVPDVK-VYTINPaTDKHVILASDGLWGVVQPDDAVRCVMW-YSCVNTwHPSYLPRLVSKALSRWRARklr
  |.  |||||.||| .  .   |   ..  | |   ... |  ||..|.|||||| |.. .||.  |   |   .| . .    |.  |.   .|.   
qtrinGlavsralGdhfikelniG...lisepyvsnrilltp.fdkflivasdGlwdvisGkdaiekvkslydqqat.edkmasslletaiqsikak...

aDNTSVIVVS
 || ||||| 
.dnvsvivvk

subfamily_PPM1G2_pd Subfamily PPM1G2 204-307 2.1e-10 33.0 In-house 180-286 (287) alignment
Range on Protein: 204-307
Range on HMM: 180-286/287.0
FLAVSRSLGDLwSFDYFR----GEFVVSPVPDVKVYTINpATDKHVILASDGLWGVVQPDDAVRCVMWYSCVNTWHPSYLPRLVSKALSRWRA-RKLRAD
 ||.||.|||  .|         | .|  |||| |  ..   |  ..|| ||.| |.. .. |  |      ..   .   .|..|.|..      . .|
nLalsralgDf.efkknvkkkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcD

NTSVIVVSF
| .|..|..
nmtvvivvl

subfamily_ILKAP_pd Subfamily ILKAP 204-266 1.5e-08 27.2 In-house 184-240 (293) alignment
Range on Protein: 204-266
Range on HMM: 184-240/293.0
FLAVSRSLGDLwsfdYFRGEFVVSpVPDVKVYTINPAtDKHVILASDGLWGVVQPDDAVRCVM
 | ||||.||      |..  |.| .||||  ....  |..|.|| |||| |.. |..|. ..
vlevsrsiGdg....rfkrlGvis.tPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfil

subfamily_PPM1L_pd Subfamily PPM1L 204-266 3.8e-08 25.9 In-house 175-233 (269) alignment
Range on Protein: 204-266
Range on HMM: 175-233/269.0
FLAVSRSLGDLWsfdyFRGEFVVSPVPDVKVYTINPATDKHVILASDGLWGVVQPDDAVRCVM
 ||.||.|||      .. . .| . ||.  . ..    . .||||||||     ..||| ..
vlatsralGdyp....lkdknlviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfik

Subfamily Dicty-PPM1L-like 204-267 4e-07 22.1 In-house 204-261 (305) alignment
Range on Protein: 204-267
Range on HMM: 204-261/305.0
FLAVSRSLGDLWSfdyfrGEFVVsPVPDVKVYTINPATDKHVILASDGLWGVVQPDDAVRCVMW
.| .||| ||         |.|. | .| ... .. | |. ..|| |||| |.. .| |  |  
llkksrskGdknl.....kelvi.PnndspllvvakanDqflvlatdGlwevlsyqdvveevke

subfamily_PPM1E_pd Subfamily PPM1E 205-307 5.4e-09 28.6 In-house 171-262 (265) alignment
Range on Protein: 205-307
Range on HMM: 171-262/265.0
LAVSRSLGDLWSFDYfrgefvVSPVPDVKVYTINPaTDKHVILASDGLWGVVQPDDAVRCVMWYSCVNTWHPSYLPrlvsKALSRWRARKLRADNTSVIV
|.|||..||  . .|      ||  .||  ....  ... .|||.|||| ||.....|. |  .   .. . | ..    | |      .  .|| .|.|
LsvsRaiGDvklkpy......vsgeadvaeveldg.seeylilacDGlwDvvneeevvklveefladgaedlseva....kllveaakeagssDnitvvv

VSF
| .
vfl

subfamily_PPM1H_pd Subfamily PPM1H 205-266 1.3e-06 20.4 In-house 281-348 (404) alignment
Range on Protein: 205-266
Range on HMM: 281-348/404.0
LAVSRSLGD--LWSFD-YFRGEFVVSPVPDVKVYTIN---PATDKHVILASDGLWGVVQPDDAVRCVM
..|.| |||  |   |       ..||||.|.|. ..     .|. .|||.|||| |.. ... . | 
igvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivr

subfamily_PPM1G_pd Subfamily PPM1G 206-264 5.8e-06 18.6 In-house 364-424 (473) alignment
Range on Protein: 206-264
Range on HMM: 364-424/473.0
AVSRSLGDLW---SFDYFRGEFVVSPVPDVKVYTINPAtDKHVILASDGLWGVVQPDDAVRC
 .|| |||       .    | ..| .||.|| |. .. |. ..||.||.| |.. .. |  
nlsRAlGDhaYkkneeLplkeqmisAlPDikvltltee.deFlvlAcDGiWnvmesqevvdf

subfamily_PDP_pd Subfamily PDP 229-270 1.2e-07 24.2 In-house 273-313 (398) alignment
Range on Protein: 229-270
Range on HMM: 273-313/398.0
VPDVKVYTINPaTDKHVILASDGLWGVVQPDDAVRCVMWYSC
 |.|  . ... .|| ..||.|||| .......|. |. . .
ePevtshklre.ndkFLvlatDGLwdllsneevvslVgehla