Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
0034914 | PP2C-like | 3-286 | 1.8e-89 | 292.2 | In-house | 2-290 (295) | alignment | ||
Range on Protein: 3-286
Range on HMM: 2-290/295.0
QTLSEPVTTKETSSCSNKSYKLASSCMQGWRINMEDAHTEILSLKE-DKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQ-------PAWAKGNVIEALK
..|| |.... ..| .. ... .....||.| ..|||.. .|.| .......||.||||| ..|... ..| . .... . ...|||.
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealr
KGFLSCDTDMLKDEQM--KDEVAGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLALSRALGDFCF
|.||..| ..|. .. .. . ||||||..|..||||.||||||||. ...| ..||..||||.||.| .||..|||.| ..||||.||..||||||..
kaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdl
KKNDKKPPEEQIVTAMPDVIVKDLT-PDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLApdcqmgGLGCDNMTVIILTF
|.. . ...|..|.|.|||.| .|| .|..||.||.||.||||||.|.||..||.||....||...|||. ..|| . ..||.||... .
klllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrl
|
|||||||||
subfamily_PPM1G2_pd | Subfamily PPM1G2 | 4-286 | 1.8e-144 | 473.0 | In-house | 1-286 (287) | alignment | ||
Range on Protein: 4-286
Range on HMM: 1-286/287.0
TLSEPVTTKETSSCSNKSYKLASSCMQGWRINMEDAHTE---ILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKGNVIEALKKGFLSC
||||||..||..||.|...|..||.|||.|.||||||.. .|....||..|...|.||||||.||.|.|..|.||||.......|.. ..||..||..
tlsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaflet
DTDMLKDEQMKDEVAGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLALSRALGDFCFKKNDKKPP
|...||||..|||.||.|||||.||..|||.||.|||||....|| |..|||||||..|.|..|||||||.||.||||||||||||||||.||||.||.|
DeellkdeklkdesaGstavvvlikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkp
EEQIVTAMPDVIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLAPDCQMGGLGCDNMTVIILTF
|||||||.|||.||.|..|.||||||||||||||.|.||||..|.||.....|..|.||||..|||||....|.|||||||.|...
eeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvl
|
|||||||||
subfamily_PPM1G_pd | Subfamily PPM1G | 5-112 | 1.7e-30 | 99.4 | In-house | 2-107 (473) | alignment | ||
Range on Protein: 5-112
Range on HMM: 2-107/473.0
LSEPVTTKETSSCSNKSYKLASSCMQGWRINMEDAHTEILSLkeDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKGNVIEALKKGFLSCDTDM
||.| . ||.. ||.. . . | ||||| ..||||..|. | |..|....|||||||. ||.|| ..| . . | ....|.| .||.. ||..|. .
lskpkvekesedesneelsygasamqGwrvsqEDahncitdl..dedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDekl
LKDEQMKD
..|..|.
kaeeslke
|
|||||||||
subfamily_PPM1A_pd | Subfamily PPM1A | 15-286 | 9.5e-89 | 290.5 | In-house | 5-280 (282) | alignment | ||
Range on Protein: 15-286
Range on HMM: 5-280/282.0
SSCSNKSYKLASSCMQGWRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAW--------AKGNVIEALKKGFLSCDTDMLK
|. ...... . | |||||..|||||| . ||.. |. .| |.|||.|..||.|| ..|...| .. .. | .| |||..|||. | .. .
sqaegnglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeaire
DEQMKD--EVAGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLALSRALGDFCFKKNDKKPPEEQI
... .. . .|.|||.|......|..||.|||||. |..| .. |. |||||...|..|| .||| | .||||.||.||||||. .|....|..|||
lstdlktadksGsTavtvlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeql
VTAMPDVIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLAPDCQmgglgcDNMTVIILTF
|.| |.| . . . ...||||||||||||||..|||...|.|| . |||.....|. ..| . . ||..|....|
vsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsr......DNlsvlvvlf
|
|||||||||
PP2Cc_SM00332 | 16-283 | 1.1e-97 | 319.7 | In-house | 4-273 (274) | alignment | |||
Range on Protein: 16-283
Range on HMM: 4-273/274.0
SCSNKSYKLASSCMQGWRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKG----NVIEALKKGFLSCDTDMLKDEQMK
| ||... . |.||||| .||||| ...|.| ....| ||.|||||..||..| ..| . ..... . |. .| |||||.|||.| ..|..||.|
sgsnlglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqsk
DE---VAGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLALSRALGDFCFKKNDkkPPEEQIVTAM
. .|.||||...|...||.||||||||. |..| . ||| ||||..|.|..|| .|||.||..||||.||.|||.||...|||. ...|...||
elenalsGstavvallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klkepyitae
PDVIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRM-ELEQICEELLTRCLAPDcqmgGLGCDNMTVII
||| | .||...|||.||.||.|||||||||||..|..||.. . | ..|||....... | ..||.||..
pdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr....ggseDniTvvv
|
|||||||||
subfamily_LRR-PP2C_pd | Subfamily LRR-PP2C | 20-262 | 1.2e-51 | 168.5 | In-house | 4-235 (255) | alignment | ||
Range on Protein: 20-262
Range on HMM: 4-235/255.0
KSYKLASSCMQGWRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKGNVIEALKKGFLSCDTDMlkdeQMKDEVAGTTA
. .|.. | | | | ||| . | ..... .. ..||||| . |.. ..|.| .|. . | ...||| . . .| . . . ||||
srfkvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi....serpkfiGtta
VVVVIKNNKLYCANVGDSRAIAC-KKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFN----RVNGNLALSRALGDFCFKkndkkPpeeqIVTAMPDVI-V
..|.| ..| | |||||||.. | |.| ..||.|||||.|.|..|| ..|| | . ||||.||.|||||| .. | |.. ||.
asvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfle.....P....fvvpdPdlsqs
KDLTPDHEFLVLACDGIWDVLSNQEVVDFIrsrlAQRMELEQICEELLT
. . ...||.||||||||..|..| |. . |. . |. .|.|
leiskkdkflilacdGiwdlisdeeaveiv....agisdpekaaeklrd
|
|||||||||
subfamily_PPM1E_pd | Subfamily PPM1E | 21-284 | 2e-57 | 187.4 | In-house | 3-260 (265) | alignment | ||
Range on Protein: 21-284
Range on HMM: 3-260/265.0
SYKLASSCMQGWRINMEDAHTEILS------LKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKGNViEALKKGFLSCDTDMLKDEQMKDEV
.|.. . .... | ||| | . . ||..|..||..|.||||| |.| ..|.. ...|. . . ||||..| .|. .|. . .
eyevsiaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklk
AGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWV---EFNRVNGNLALSRALGDfcfkkndkkPPEEQIVTAMPDV
.|.|||||.|....|| | .|||.|. ..|| . || |||..|.| .|| .||| | . ||||.|..|||.|| . ... |.. .||
sGstavvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGD.........vklkpyvsgeadv
IVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRM-ELEQICEELLTRCLAPDCQmgglgcDNMTVIIL
.|. ..|.|.|||||.|||. ..|||. ... ||. .|... ..|.. . . ||.||..
aeveldgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss......Dnitvvvv
|
|||||||||
0049733 | PP2C-like | 22-285 | 2e-61 | 200.1 | In-house | 3-232 (235) | alignment | ||
Range on Protein: 22-285
Range on HMM: 3-232/235.0
YKLASSCMQGW-RINMEDAHTEilslkedkNTAFLGVYDGHGGARVAQYVGQNLQKKIASQ-PAWAKGNVIEALKKGFLSCDTDMLKDEQM--KDEVAGT
.. . ....|. | ..|||. ......|.|||||....... ..| . .... .. ...|||.| || ... .|. . . . ||
lsvgaasdigrvrkvneDavlv........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmgt
TAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVefnRVNGNLALSRALGDFCFKkndkkppeeqivtamPDVIVKDLT
||||... ..|||.||||||||. ...| ..||..||.|.||.| .|||.|||.| ||.| |||.|||||...| ||| | .|.
TavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvlele
PDHeFLVLACDGIWDVLSNQEVVDFIRSrlaqrMELEQICEELLTRCLApdcqmgGLGCDNMTVIILT
|.. ||.||.||.|||||..|.||..|| ..||...|.|. ..|| . |.||.||...
pgd.flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvvr
|
|||||||||
PPM_PTC7 | 23-269 | 1.5e-87 | 286.3 | In-house | 2-255 (259) | alignment | |||
Range on Protein: 23-269
Range on HMM: 2-255/259.0
KLASSCMQGWRINMEDAHTEILSLK---EDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKG-NVIEALKKGFLSCDTDMLKDE--QM-KDEVA
.. .|..||.| .|||||. | ... ||..|.||||| ..|.|....| ....... .. ....||.|.||..|||. .. .. ...
dggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepsts
GTTAVVVVIKNNKLYCANVGDSRAIACKKGLVE-QLSFDHKPSNEEETRRIIAAGGWVE---FNRVNGNLALSRALGDFCFKKNDKkppEEQIVTAMPDV
|.||||..| ..|||.||||||||. |..| . ||..|||||||.| .|| .|||.|. ..||||.||.|||.|||..|.. . ||| |.| ||.
GstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePdi
IVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRmELEQICEELLTRCLAPDC
. ......|||.||.||.|||.|.||.||..||.|... ... ..|.|.. ..|...
sstkideedefliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargs
|
|||||||||
PP2C | Protein phosphatase 2C | 23-269 | 2.6e-85 | 279.1 | Pfam-A | 2-251 (255) | alignment | ||
Range on Protein: 23-269
Range on HMM: 2-251/255.0
KLASSCMQGWRINMEDAHTEILSL---KEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKG-NVIEALKKGFLScDTDML--KDEQM-KDEVA
.. .|..||.| .|||||. . .| . ... ||..|.||||| ..|.| ...|......|. .. .| .||.|.||. |||. ..... ...
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfla.dtdeelksskantepsks
GTTAVVVVIKNNKLYCANVGDSRAIACKKGLVE-QLSFDHKPSNEEETRRIIAAGGWVE-FNRVNGNLALSRALGDFCFKKNDkkppeEQIVTAMPDVIV
|.||||..|...|||.||||||||. |.|. . .|..|||||.|.|..|| .|||.|. ..||||.||.|||||||..|... ||.|.| ||| .
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts
KDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLAPDC
.||...|||.||.||.|||||.||.||..||.| . ......|||.. ..|. .
vklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs
|
|||||||||
PP2C | Protein phosphatase 2C | 23-269 | 2.6e-85 | 279.1 | In-house | 2-251 (255) | alignment | ||
Range on Protein: 23-269
Range on HMM: 2-251/255.0
KLASSCMQGWRINMEDAHTEILSL---KEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWAKG-NVIEALKKGFLScDTDML--KDEQM-KDEVA
.. .|..||.| .|||||. . .| . ... ||..|.||||| ..|.| ...|......|. .. .| .||.|.||. |||. ..... ...
dvgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfla.dtdeelksskantepsks
GTTAVVVVIKNNKLYCANVGDSRAIACKKGLVE-QLSFDHKPSNEEETRRIIAAGGWVE-FNRVNGNLALSRALGDFCFKKNDkkppeEQIVTAMPDVIV
|.||||..|...|||.||||||||. |.|. . .|..|||||.|.|..|| .|||.|. ..||||.||.|||||||..|... ||.|.| ||| .
GstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts
KDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLAPDC
.||...|||.||.||.|||||.||.||..||.| . ......|||.. ..|. .
vklteedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargs
|
|||||||||
subfamily_PPM1L_pd | Subfamily PPM1L | 23-249 | 7.6e-50 | 162.6 | In-house | 6-238 (269) | alignment | ||
Range on Protein: 23-249
Range on HMM: 6-238/269.0
KLASSCMQGWRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQP---AWAKGNVI-----EALKKGFLSCDTDMLKDEQMKDEV
. | ...| | .||| . .|.. .. |..|.||||| |... . | |.| .. . .| | . . |.. || |...|. . . ..
qvavysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedi
AGTTAVVVVIKNNKLYCANVGDSRAIAC-KKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFN---RVNGNLALSRALGDFCFKkndkkppEEQIVTAMPD
|||||.. ......| ||||||| . . |.| ||||||| . .| .|| |||.. |. ||.| || ||||||. .| ....| | ||
aGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.......dknlviadpd
VIVKDLTP-DHEFLVLACDGIWDVLSNQEVVDFIRSRLAQ
.. || . |||.||.||.|| .||.| | ||. || .
iltfdlddhkpeflilasdGlwdtfsneeavrfikerlke
|
|||||||||
PPM_PTC7_SpoIIE | 23-266 | 2.8e-48 | 157.7 | In-house | 2-223 (230) | alignment | |||
Range on Protein: 23-266
Range on HMM: 2-223/230.0
KLASSCMQGWRINMEDAHTEILSL---KEDKNTAFLGVYDGHGGARvaQYVGQNLQKKIASQPaWAKGN-VIEALKKGFLSCDTDMLKDeqmkDEVAGTT
.. .|..||.| .|||||. . .. ...|..||||| ... | ...... | .. . |.|....| ...|. .. ... |.|
dggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede....psssgaT
AVVVVIKNNK--LYCANVGDSRAIACKK--GlveqlsfdhkpsneeETRRIiAAGGWVE----FNRVNGNLALSRALGDFCFKKndkkppEEQIVTAMPD
|||..| ... ||.||.|||... ... | | .|| .|||... ..||.|.||.|.| ||. .. ....|.| ||
avvalidpstgklyvanaGdsppllvrddgg...............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd
vIVKDLT-PDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRmeleqICEELLTRCLA
. ... ..|||.||.||.|||||.||.||..|..| . ..|.||. ...
.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDit
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 24-174 | 1.5e-30 | 99.3 | In-house | 4-173 (309) | alignment | ||
Range on Protein: 24-174
Range on HMM: 4-173/309.0
LASSCMQGWRINMEDAHTEILSLKED---KNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAWA---KGNVIEALKKGFLSCDTDMLKDEQ-------M
..|.. || | ||| . |. .| .. ||..|.||||| |... ..| ..| | . . .|.||....||.. . | | .
vtseadqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksg
KDEVAGTTAVVVVIKNNKLYCANVGDSRAIACKKGL------VEQLSFDHKPSNEEETRRIIAAGGWVEF
. ||||| ||.|...||| |.||||... .| ..| ||||.. ||..|| .|| |
llstaGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaa
|
|||||||||
subfamily_ILKAP_pd | Subfamily ILKAP | 26-257 | 5.9e-43 | 140.1 | In-house | 9-253 (293) | alignment | ||
Range on Protein: 26-257
Range on HMM: 9-253/293.0
SSCMQGWRINMEDAHTEILSLKED--------KNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPAW----A-KGNVIEALKKGFLSCDTDMLKDEQMKD
.. .| | .|.|||. . .|.|. .. .. .|.|||.| | .... ..|.||| .. . | . .. .| . | | ..|| . .
yaerkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskak
EV--AGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQ------LSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLALSRALGDFCFKKNDkkppeeqi
| |.||.||.. .| || ||.|||.|. ..| . |. ||.| ..|| .|| ||| |. .||.| | ||..|| ||.
PvWkdGstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlG........
VTAMPDVIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQIC
|.. ||| .||.. |.||||||.|.|.|..|||.|| . | .. . ..|
vistPdvkkceLtendlfvvlaCdGLwkvfsadevvkfilkvledeeddrkik
|
|||||||||
subfamily_PPM1K_pd | Subfamily PPM1K | 28-247 | 1.1e-38 | 125.9 | In-house | 10-229 (263) | alignment | ||
Range on Protein: 28-247
Range on HMM: 10-229/263.0
CMQGWRINMEDAhTEILSLkeDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQPaWAKGNVIEALKKGFLSCDTDMLKDEQMK-----DEVAGTTAVVV
..| | . || ... | |.. ...|.|||.|. |..| ..|.| . .. . ||. |. .|... . ... . .|||| |.
sliGkraenedr.iklkel..dpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGttatvs
VIKN-NKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFN-----RVNGNLALSRALGDFCFKKNDkkppeeqiVTAMPDVIVKDL
.... ..| |..|||||| |..| ..|. ||.|. ||| .|| |||| ||.| .||| ||..|.|||. .|. | | |. ..
llrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryG........viatPetkslkv
-TPDHEFLVLACDGIWDVLSNQEVVDFIRSRL
. |||| ||| .|...||. |..|
dhaadsflvlitdgisfvvnsqelcdlvrlch
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 28-76 | 4.1e-09 | 28.7 | In-house | 13-61 (305) | alignment | ||
Range on Protein: 28-76
Range on HMM: 13-61/305.0
CMQGWRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQK
.. | . || . .||..... ..||.|||.| . |.|| ..| .
vsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklve
|
|||||||||
subfamily_KAPP-like_pd | Subfamily KAPP-like | 31-285 | 4.6e-28 | 91.0 | In-house | 7-265 (266) | alignment | ||
Range on Protein: 31-285
Range on HMM: 7-265/266.0
GWRINMEDAHTEILSLKEDKN------TAFLGVYDGHGGARVAQ----YVGQNLQKKIASQPAWAKGNVIEALKKGFLSCDTDMlkDEQM-KDEVAGTTA
| ..||| . | | ..|. |...|.||| | .|. . ..|.|.. | |. | .| .. .. |... . | |.||
gcstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkev..daklkdfeyeGata
VVVVIKN----NKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEF--NRVNGnLALSRALGDFCFKKNDKKPPEEQIVTAMpdviv
.... . | .|||||| |. .. .||.||| ..|| .|| | . |.|| ||.|||||| |. . | |.
tlalvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlisepyvsnr.....
KDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLtrclapDCQMG-GLGCDNMTVIILT
||| ..||..| ||.|||.| .. .. ..| |. ..... || .. .. . ||..||...
illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmassll......etaiqsikakdnvsvivvk
|
|||||||||
subfamily_Dicty-PPM-1_pd | Subfamily Dicty-PPM-1 | 31-285 | 2.6e-24 | 78.5 | In-house | 6-275 (276) | alignment | ||
Range on Protein: 31-285
Range on HMM: 6-275/276.0
GWRINMEDAHTEILSLKEDKN------TAFLGVYDGHGGARVAQ----YVGQNLQKKIAS-----QPAWAKGNVIEALKKGFLSCDTDMlkDEQMKD-EV
| ..||| . | | ..|. |...|.||| | .|. ..|.| . | |. | .| .| .. |...|| |
gcstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkev..daklkdfey
AGTTAVVVVIKNNK----------LYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEF--NRVNGnLALSRALGDFCFKKNDKKPPEE
|.|| .... .. | .|||||| |. .. .||.||| .. || .|| | . |.|| ||.|||||| |. . |
eGatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikddGitlsdnqtrinG.lavsralGdhfikelniGlise
QIVTAMpdvivKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLtrclapDCQMG-GLGCDNMTVIILT
|. ||| ..||..| ||.|||.| .. .. ..| |. ..... || .. .. . ||..||...
pyvsnr.....illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmassll......etaiqsikakdnvsvivvk
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 32-81 | 2.7e-08 | 26.0 | In-house | 13-62 (492) | alignment | ||
Range on Protein: 32-81
Range on HMM: 13-62/492.0
WRINMEDAHTEILSLKEDKNTAFLGVYDGHGGARVAQYVGQNLQKKIASQ
|. .|||..| .| |..|.|.|||. || |. ..|.. ....
WKskmeDkrtlqdyfgndvnscFfgiyDGynGataAeiaakelhevllee
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 36-81 | 2.7e-06 | 19.8 | In-house | 11-54 (398) | alignment | ||
Range on Protein: 36-81
Range on HMM: 11-54/398.0
MEDAHTEILSLKEDknTAFLGVYDGHGGARVAQYVGQNLQKKIASQ
.|| ..| .|... ..|| |||||| |. | ..| | .| .
iEDrrseakllesn..gvlfgvfDGHggaacaeavskrLlkyvaas
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 46-248 | 8.6e-10 | 31.3 | Pfam-A | 18-196 (212) | alignment | ||
Range on Protein: 46-248
Range on HMM: 18-196/212.0
LKEDKNTAFLGVYDGHGGARV--------AQYVGQNLQKKIASQPAWAKGNVIEALKKGFLS-C---DTDMLKdeQMKDEVAGTTAVVVVIKNNKLYCAN
.|... .| | ||.| |. .. .|. |.|..... . .. ........ | . . . . |.. . .|| ...||.........
ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivffq
VGDSRA-IACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFnrvngnlalsralgdfcfkkndkkppeeqivtampdvIVKDL-TPDHEFLVLACDGIW
.||... . . | |..|. ... . ||... . . |. .. | ... . |.| ||..
iGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.....................................rirrlklepgdalllmTDGvs
DVLSNQE-VVDFIRSRLA
| |...| . .... .|.
dslrkeepfrellaelle
|
|||||||||
PP2C_2 | Protein phosphatase 2C | 46-248 | 8.6e-10 | 31.3 | In-house | 18-196 (212) | alignment | ||
Range on Protein: 46-248
Range on HMM: 18-196/212.0
LKEDKNTAFLGVYDGHGGARV--------AQYVGQNLQKKIASQPAWAKGNVIEALKKGFLS-C---DTDMLKdeQMKDEVAGTTAVVVVIKNNKLYCAN
.|... .| | ||.| |. .. .|. |.|..... . .. ........ | . . . . |.. . .|| ...||.........
ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaq..qeelkdyatTlllavitpgeivffq
VGDSRA-IACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVEFnrvngnlalsralgdfcfkkndkkppeeqivtampdvIVKDL-TPDHEFLVLACDGIW
.||... . . | |..|. ... . ||... . . |. .. | ... . |.| ||..
iGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.....................................rirrlklepgdalllmTDGvs
DVLSNQE-VVDFIRSRLA
| |...| . .... .|.
dslrkeepfrellaelle
|
|||||||||
subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 49-192 | 2.1e-22 | 73.0 | In-house | 17-185 (292) | alignment | ||
Range on Protein: 49-192
Range on HMM: 17-185/292.0
DKNTAF-LGVYDGHG--GARVAQYVGQNLQKKIASQPAwAKGNVIEALKKGFLSCDTDMLKDEQMKDEVAGTTAVVVVIKNN-KLYCANVGDSRAIACK-
. .| |.|||| | .|||. ..|.... . . .. ||| .. |. . . | . | |.|..| ..... .|. ||||||||. .
sealtflaavldGhGvnGdkvaqlaedtlevelleltr.qlqelsealllrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrc
----KGLVEQLSFDHKPSNEEETRRIIAAGGWVE-----------FNRV------NGNLALSRALGDFCF
. . || ||||.. .| .|| .||| || || .|.|||||||||| .
lggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhl
|
|||||||||
PP2C_SIG_SM00331 | 49-285 | 2.1e-13 | 43.3 | In-house | 26-216 (217) | alignment | |||
Range on Protein: 49-285
Range on HMM: 26-216/217.0
DKN-TAFLGVYDGHG----GARVAQYVGQNLQKKIASQpawakgnviEALKKGFLSCDTDMLKDeqMKDEVAGTTAVVVVI--KNNKLYCANVGDSRAIA
... . .| | ||.| .| .. . . |.. . .. |.|.. . .. . . ... ..|... .. ...||. ||.|||| .
lnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.........eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyl
CK-KGLVEQLSFdhkpsneeetrriiaaggwvefnrvngnlalsralgdfcfkknDKKPPEEQIVTAMPDVIVKDLTPdHEFLVLACDGIWDVL-----S
..|||.|.. . .| ... ..|. .| . ..|.|. ||....
lrdgklveilkd...........................................vegaplGlepevsvdirelelek.gdllllytDGltearsekgfa
NQEVVDFIRSRLaqRMELEQICE----ELLTRCLAPDCqmgglgCDNMTVIILT
.... ..... . .|.... . |||.. .. |..||...
eerleeiledlv..dseaqelaqkiveellelakgsng......eDdiTvvvvk
|
|||||||||
subfamily_PHLPP_pd | Subfamily PHLPP | 50-245 | 6.4e-12 | 37.9 | In-house | 25-214 (246) | alignment | ||
Range on Protein: 50-245
Range on HMM: 25-214/246.0
KNTAFLGVYDGHGGARVAQYVGQNLQKKIASQpAWAKGNVIEALKKGFLSCDTDMLKDeqmkDEVAGTTAVVVVIKNNK--------LYCANVGDSRAIA
.. | |..||. ... . . ... .. . . |. | .|. .| . .. .. | |..|... |...| | |.|| |.
svealyGlfdGdrneelssllqrlmkdvlkee.vqkdkneeeymkntllvaqrklGea....GeklgsaallilirhdkvdPaksfsLevAsvGtlqavl
CKKGLVEQLSFDHKPSNEeETRRIIAAGGWV-EFNRVNGNLALSRALGDFCFKkndkkPpeeqIVTAMPDVIVKDLTPDHEFLVLACDGIWDVLSNQEVV
...| .|| .. ... | .|| | . . | |..|| .. .| || . | .| | | ||.. |.|.. . .|.||| .|.|
iRngkklrlsksyviekd.elkrikeakaiitednkingviestrllGytflf.....P....vvlPkphvrevlLteqdellivGnkalWevlsideav
DFIRS
. .|
eavrk
|
|||||||||
subfamily_PDP_pd | Subfamily PDP | 88-256 | 6.8e-27 | 87.6 | In-house | 114-321 (398) | alignment | ||
Range on Protein: 88-256
Range on HMM: 114-321/398.0
NVIEALKKGFLSCDTDMLKDEQ-----------MKDEVAGTTAVVVVIKNNKLYCANVGDSRAIACKK---G--LVEQLSFDHKPSNEEETRRIIAAGG-
.| |||||.||..| |. .. . .. ..|..|....|....|. ||.||.||. ... | . .|| |. .|||| .|| ..
kvkealkkaFlklDkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPg
-----WVEFNRVNGNLALSRALGDFCFKKND---KKPPEE--------------QIVTAMPDVIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLA
. .|. |.|. .|| ||. .| . ||. |. .|| |.|. . |... ||||| ||.||.|||.|||. . ||
eesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklrendkFLvlatDGLwdllsneevvslVgehla
QRMELEQI
...| |..
kkkekepv
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 89-162 | 5.2e-17 | 54.7 | In-house | 136-209 (404) | alignment | ||
Range on Protein: 89-162
Range on HMM: 136-209/404.0
VIEALKKGFLSCDTDMLKDEQMKDEVAGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEET
|| || . ||..| . .... | ||.|... ..||| || |||||| ..|. . .||.|. | | .
viGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsadftPeteRqR
|
|||||||||
subfamily_TAB1_pd | Subfamily TAB1 | 110-237 | 9.4e-25 | 80.1 | In-house | 123-263 (333) | alignment | ||
Range on Protein: 110-237
Range on HMM: 123-263/333.0
MKDEV-AGTTAVVVVIKNNKLYCANVGDSRAIACK---KGLVEQLSFDHKPSNEEETRRIIAAG---GWVEFNRVNGNLALSRALGDFCFKKNDK-----
...|. ||||||..| ||||| ||||||||...| . |.||| ||. ||.| |. | .. |.. |. |..||.. || |
leeeisgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgskentRsiGdykvkkgykdvdil
KPPEEQIVTAMPDVIVK-DLTPDHEFLVLACDGIWDVLSNQ
. ... | | ||.. .... |||| ||. | .
ssakgePviaePdiqgaypiddityflvlmSdGvyktLeev
|
|||||||||
subfamily_PPM1G_pd | Subfamily PPM1G | 115-286 | 9.8e-76 | 248.6 | In-house | 296-470 (473) | alignment | ||
Range on Protein: 115-286
Range on HMM: 296-470/473.0
AGTTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVE-FNRVNGNLALSRALGDFCFKKNDKKPPEEQIVTAMPDVIV
.||||||...|..||. ||.||||.. ...| .|| |||| .|.|..|| .||| |. |||| | |||||||...||| . |..||...|.||. |
sGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDikv
KDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRM--ELEQICEELLTRCLAPDCQMGGLGCDNMTVIILTF
. ||...|||||||||||.|.. ||||||.|..|... |..|.|||| ||||| . | |||||||||...
ltlteedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll
|
|||||||||
subfamily_Choan-PPM-1_pd | Subfamily Choan-PPM-1 | 116-270 | 1.6e-06 | 19.6 | In-house | 135-305 (317) | alignment | ||
Range on Protein: 116-270
Range on HMM: 135-305/317.0
GTTAVV-VVIKNNKLYCANVGDSRAIAC---------KKGL-VEQLSFDHKPSNEEETRRIIAAGGWVEFNRVNGNLAL-SRALGDFCF---KKNDKKPP
|||||| ||. . .. .|| ||. |. . || || || |. ..| |. . . .| || || .. | .|
GttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaayelqltkslGhkll
EEQIVTAMPDVIVKDLTPDHEFLVLAC-DGIWDVLSNQEVVDFIRSRLAQRMELEQICEELLTRCLAPDCQ
. |.| |.| .. | | | |... ||| | |....|.| . . . |..|.. .|. ..
kraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraataleasevlcddaqdylldetsi
|
|||||||||
subfamily_PP2D1_pd | Subfamily PP2D1 | 117-252 | 3.6e-21 | 68.4 | In-house | 178-314 (492) | alignment | ||
Range on Protein: 117-252
Range on HMM: 178-314/492.0
TTAVVVVIKNNKLYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGGWVE----FNRVNGNLALSRALGDFCfkkndkKPPEEQIVTAMPDVI
. | .. || ||.|. .|. |..| .| .| | |..| .|. ||. | .||| | | || . | .. | | ..
ngsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyG......dpkLkksvipePktt
VKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRM---E
|. ||||| |.|.|||..||. ... ||. .
svkldeaaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvr
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 117-189 | 8.8e-07 | 21.0 | In-house | 216-294 (305) | alignment | ||
Range on Protein: 117-189
Range on HMM: 216-294/305.0
TTAVVVVIKNNK-LYCANVGDSRAIACKKGLVEQLSFDHKPSNEEETRRIIAAGG---W--VEFNRVNGNLALSRALGD
.. .|. .... | |. .|.. . .. || | ||..... . .| |. .. | | || ...|..| ||
lkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD
|
|||||||||
subfamily_PPM1H_pd | Subfamily PPM1H | 175-250 | 1.1e-10 | 33.9 | In-house | 275-354 (404) | alignment | ||
Range on Protein: 175-250
Range on HMM: 275-354/404.0
NRVNGNLALSRALGDFCFKKNDKKPPEEQIVTAMPDVIVKDLTP----DHEFLVLACDGIWDVLSNQEVVDFIRSRLAQR
.|. . .. .| ||| | |.. .....|.| | ||| . . |.|| ||.||||||.|| .|. |..
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskv
|
|||||||||
subfamily_Dicty-PPM1L-like_pd | Subfamily Dicty-PPM1L-like | 176-285 | 5.2e-08 | 25.1 | In-house | 200-302 (305) | alignment | ||
Range on Protein: 176-285
Range on HMM: 200-302/305.0
RVNGNLALSRALGDFCFKKNDKkPPEEQIVTampdVIVKdltPDHEFLVLACDGIWDVLSNQEVVDFIRSRLAQRMELEQI---CEElLTRCLAPDCQMG
.||. | || || |. |.... . |. | .. .||||| ||.|.|||.|.||.... | ... ..| .| . | .
lvnrllkksrskGdknlkelvi.Pnndspll....vvak...anDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfne.isrviveeavkr
GLGcDNMTVIILT
| | ||.|..|.
gsg.Dnitlviik
|
|||||||||
subfamily_PPM1D_pd | Subfamily PPM1D | 181-286 | 1.2e-14 | 47.1 | In-house | 201-307 (309) | alignment | ||
Range on Protein: 181-286
Range on HMM: 201-307/309.0
LALSRALGDFCFKKNDKkppEEQIVTAMPDVIVKDLTPDHE-FLVLACDGIWDVLSNQEVVDFIRSRLAQRMEL----EQICEELLTRCLApDCQMGGLG
||..|.|||. .. . .| .| ||| |. |.|..| |..|| ||.|.||. ...|..... .... ... . |... | . |
LavaRslGDlWsynaks...gefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealq.rwrskklr
CDNMTVIILTF
.||..||....
aDnvsvivvil
|
|||||||||
subfamily_Choan-PPM1K-like_pd | Subfamily Choan-PPM1K-like | 211-245 | 9.8e-07 | 21.6 | In-house | 238-272 (292) | alignment | ||
Range on Protein: 211-245
Range on HMM: 238-272/292.0
VIVKDLTPDHEFLVLACDGIWDVLSNQEVVDFIRS
. |.| | .||||| ||. |||.|.||| ..
klekeldsddaflvlasdGvldvllnaevvlllak
|
|||||||||
PPM_PTC7_SpoIIE_motif | 221-285 | 1.5e-09 | 31.4 | In-house | 13-79 (81) | alignment | |||
Range on Protein: 221-285
Range on HMM: 13-79/81.0
EFLVLACDGIW-------DVLSNQEVVDFIRSRlaQRMELEQICEELLTRCLApdcQMGGLGCDNMTVIILT
. |.|..||.. ......|........ . ..|......|. ..|. . .| |..|...|
dvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvlr
|
|||||||||
PPM_PTC7_motif | 224-269 | 3.7e-17 | 55.6 | In-house | 1-47 (51) | alignment | |||
Range on Protein: 224-269
Range on HMM: 1-47/51.0
VLACDGIWDVLSNQEVVDFIRSRLA-QRMELEQICEELLTRCLAPDC
.||.||.|||||.||.||..|..|. .. ......|.| ...||. .
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargs
|