Gene PPM1H in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1H
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP147_AA protein Get Run
NvecP147_AA_42-431 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPM1H_pd Subfamily PPM1H 38-431 3.4e-179 588.8 In-house 6-402 (404) alignment 
Range on Protein: 38-431
Range on HMM: 6-402/404.0
HRELPLNAGYAEAINAGKTLHkNEDQALAGMFCLNLDKKTRPAGNEAgrssPTHITQTKIPYACFGVFDGHAGEGASLMAVNTLHIHIMEKLSSVKELLT
 |.||..|||||.|||||. . ||||| | ...|. .||.. . ...    .......|.|.|.||.||||||.||.|.|...|| |..|||..|.|||.
lrrlPwaaGYaevinagksel.neDqaaakvlllkkekkeksvtskp....kekseeeklplayfglfDGhaGsgaalvaskllhkhlkekledvlelll

CKSDEKLALSPQLA-------EA--VVSSISIDKLVIGALEEAFFEMDEQIRRERNTYRITGGCTAVVALFLGKKLYVANAGDSRAIVSQKGKLIELSMD
.||.|.    ..         .     ..|| ..|||||||.||.||||||.|||..|||.|||||.|||.| .|||||||||||||...|...|.||.|
eksaeeeenteesskespssvseiyeekeiskeeLviGalesaflemDeqiarereayrikGGCtalvalvllgklYvanaGDsRailvrkdeiiplsad

FTPETERRRLQLIAYQKPHLLGSEFGRLEFQQRARKKFVGQKLLYRDRHMSGWAHKIVTEEDAqKFPMITGEGKKARLLDTIGTTRGFGDHDLKVPYCNL
|||||||.||| .|..||.|||.||.|||||.|..|| .||..||||..|.|||.| |.|||  |||.|.|||||||||.|||.|||.|||.||| ..||
ftPeteRqRlqelaflkPeLlgkeftrlefqkRlkkkdlgqrvlyRdqnmtGWayktveeeDl.kfplisgegkkaRllatigvtRGlGDheLkvvdtnl

SIKPFLTPEPEVMTYDLTQCKHDEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPKHDKRRYVVAAQTLVAEAKGVLTEKGWRRACGEMGSYDDITAFV
||||||.|.|||...||||....||||||.||||||..|.| ...|||.||..|....||.||...||.|||.|.|.|..|||| ......|.|||..||
sikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkrytavaqeLvaaarGklkdkgWrlkeekaasvDDisvfv

IPL
|||
iPl
0034914 PP2C-like 43-431 7.7e-53 172.2 In-house 19-290 (295) alignment 
Range on Protein: 43-431
Range on HMM: 19-290/295.0
LNAGYAEAINAGKtLHKNEDQALAGMFCLNLDKKtrpagneagrsspthitqtkipYACFGVFDGHAGEGASLMAVNTLHIHIMEKLSSVKELLTCKsde
|.  .. | . |.  ..|||. |. . .|.|...                      ...||||||| |  |. .| ..|. ...| | ..  |||     
lllrvgvasdqGr.rksneDavlvvlnllslled......................lllfgvfDGhgGhaaaevasellvelllellekllllltls...

klalspqlaeavvssisiDKLVIGALEEAFFEMDEQIRRERNT--YRITGGCTAVVALFLGKKLYVANAGDSRAIVSQKGKLIELSMDFTPETERRRLQL
                  .  .. ||..|| ..||.....     .....|.||||||. |.||||||.|||||... .|.|. |. | .|  |  |  .
..................ledieealrkaflaadeellelallrpelagsGtTavvalirgnklyvanvGDSravllrngelvqltvdhkpvnelereri

IAYQkphllgsefgrlefqqrarkkfvgqkllyrdrhmsgwahkivteedaqkfpmitGEGKKARLLDTIGTTRGFGDHDLKVPYCNLSIKPFLTPEPEV
...                                                       |     |.....  || .||.|||... .| ..|....||.|
lsag......................................................gavshgrvngvlavtRalGdfdlklllslllleplvsaePdv

MTYDLTqckHDEDDVLIIATDGLWEKLTNLKALEIVAEVFQKtpkhdKRRYVVAAQTLVAEAKGvltekgwrracgeMGSYDDITAFVIPL
....||   ...||.|..|.||||. |.|  ...||.....|        . .||. || .|                ||.|.||..|. |
tvlelt...ledddfllLasDGlwdvlsneeivdivrsllak.....gldleeaaeeLvdlAla.............rgsrDNiTvvvvrl
0049733 PP2C-like 47-430 4.1e-36 117.5 In-house 5-232 (235) alignment 
Range on Protein: 47-430
Range on HMM: 5-232/235.0
YAEAINAGKTLHKNEDQALAgmfclnldkktrpagneagrsspthitqtkiPYACFGVFDGHAGEGASLMAVNTLHIHIMEKLSSvkeL---Ltcksdek
.. |   |.  . |||  |.                                ...|.|.||| |  |. .| ..|. ...| | .   |           
vgaasdigrvrkvneDavlv...............................glllfavaDGhgghaagevasellvetllellle...lllld.......

lalspqlaeavvssisidklVIGALEEAFFEMDEQIRRERNTY--RITGGCTAVVALFLGKKLYVANAGDSRAIVSQKGKLIELSMDFTPETERRRLQli
                    .. ||..|| ...|.....  ..  . ..|.||||||. |.||||||.|||||.. ..|||. |. | .|  |  |    
....................leealrkaflaaneallelalaspelagmgtTavvalldggklyvanvGDsrayllrdgklvqltedhspvnelerqr..

ayqkphllgsefgrlefqqrarkkfvgqkllyrdrhmsgwahkivteedaqkfpmITGEGKKARLLDTIGTTRGFGDHDLKvpycnlsikpfltpepevm
                                                       |. .|   | .. .  || .||..||                   
.......................................................iitaggavrvpgrlaltralGdlllk...................

tYDLTQCKHDEDDVLIIATDGLWEKLTNLKALEIVAEvfqktpkhdkRRYVVAAQTLVAEAKGvltekgwrracgeMGSYDDITAFVIP
 .|.|... ...|.|..|.||||. |..  .......            .  ||..|| .|                |..|.||. |. 
.pdvtvlelepgdflllasDGlwdvlsdeeivdllrs..........ldleeaaerlvelala.............rggrDNiTvvvvr
PPM_PTC7 94-237 8.1e-24 77.4 In-house 29-149 (259) alignment 
Range on Protein: 94-237
Range on HMM: 29-149/259.0
QTKIPYACFGVFDGHAGEGASLMAVNTLHihimEKLSSVKELLTCKsdeklalspqlaeavvssisidkLVIGALEEAFFE--MDEQIRR-ERNTYRITG
. |.. | |.|||||.|  |.  | ..|.    |.| . |.. ...                       ... || ..| .  .|| ... | ||  .|.
sgkdsvaffavfdghggreaakyarehle....eilkerksfeele.......................klekalrksflaldtdeelksseantepsts

GCTAVVALFLGKKLYVANAGDSRAIVSQKGKLI-ELSMDFTPETERRR
|.||||||. |.||||||.|||||.....|. . .|. |..|. |. |
GstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEr
PP2C Protein phosphatase 2C 94-237 3.2e-22 72.3 Pfam-A 29-150 (255) alignment 
Range on Protein: 94-237
Range on HMM: 29-150/255.0
QTKIPYACFGVFDGHAGEGASLMAVNTLHihimEKLSSVKELLTCKsdeklalspqlaeavvssisidkLVIGALEEAFFE-MDEQIRR-ERNTYRITGG
. |.. | |.|||||.|. |. .| ..|.    |.| . |..|...                       .|  || ..| . .||.... . ||  .. |
sgkssvaffavfdghggreaakyarehle....eilkeqksflele.......................kvekalrksfladtdeelksskantepsksG

CTAVVALFLGKKLYVANAGDSRAIVSQKGKLI-ELSMDFTPETERR--R
.||||||. ||||||||.|||||....|.. . ||. | .|. |.   |
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreR
PP2C Protein phosphatase 2C 94-237 3.2e-22 72.3 In-house 29-150 (255) alignment 
Range on Protein: 94-237
Range on HMM: 29-150/255.0
QTKIPYACFGVFDGHAGEGASLMAVNTLHihimEKLSSVKELLTCKsdeklalspqlaeavvssisidkLVIGALEEAFFE-MDEQIRR-ERNTYRITGG
. |.. | |.|||||.|. |. .| ..|.    |.| . |..|...                       .|  || ..| . .||.... . ||  .. |
sgkssvaffavfdghggreaakyarehle....eilkeqksflele.......................kvekalrksfladtdeelksskantepsksG

CTAVVALFLGKKLYVANAGDSRAIVSQKGKLI-ELSMDFTPETERR--R
.||||||. ||||||||.|||||....|.. . ||. | .|. |.   |
stavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreR
subfamily_PPM1D_pd Subfamily PPM1D 94-221 4.7e-15 48.5 In-house 31-139 (309) alignment 
Range on Protein: 94-221
Range on HMM: 31-139/309.0
QtKIPYACFGVFDGHAGEGASLMAVNtlhiHIMEKLSSVKELlTCKSDEKLalspqlaeavvssisidklvIGALEEAFFEMDEQIRRER-------NTY
. .. .|...||||| |. |.  | .    |.....   |.. . ...|..                    . |..|||... |......       . .
e.elevafvavfDGHGGkeAakfare....hlwsvikkqkkf.lssepedv....................leAireaflatheamkkkleeWpktksgl

RITGGCTAVVALFLGKKLYVANAGDSRAIVSQKGK
  | | || | .. ..|||||. |||......| .
lstaGttasvviirreklyvahvGDsaivlgvkep
subfamily_PPM1E_pd Subfamily PPM1E 95-237 7.7e-19 60.9 In-house 36-149 (265) alignment 
Range on Protein: 95-237
Range on HMM: 36-149/265.0
TKIPYACFGVFDGHAGEGASLMAVNTLHIHIMEKLSSVKELLtcksdeklalspqlaeavvssisidklviGALEEAFFEMDEQIRRERNTYRITGGCTA
 . ..| |.|||||.|  |.  | . || ..... .  .. .                              ||.||| ..||.. .  .  ....|.||
dekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.............................ealkeafkltDerflqkaereklksGsta

VVALFLGKKLYVANAGDSRAIVSQKGKLIELSMDFTPETERRR
||.|  ...||||  |||.|.. .||. ..|     || |. .
vvvliekdqlyvaWlGDsqallvrkgeavqlmkpHkPeredEk
subfamily_PPM1L_pd Subfamily PPM1L 96-237 1.3e-15 50.4 In-house 32-154 (269) alignment 
Range on Protein: 96-237
Range on HMM: 32-154/269.0
KIPYACFGVFDGHAGEGASLMAVNTLHIHIMEKLSSVkelltcksdeklalspQ-------LaeavvssISIDKLVIGALEEAFFEMDEQIRRERNtyri
|.    |.||||| || |. .| . |   |..||  .                .               |. .||.   .  .  .. |...|. .    
ktgesffavfdGhGGefaaefakdvlvkaiknkliel................dadkentep.......infsklltdeilsvdekllekakraed....

TGGCTAVVALFLGKKLYVANAGDSRAIV-SQKGKLIELSMDFTPETERRR
. |.||..||  ...| ||| |||| ..  ..|| | || |  |.  . |
iaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvker
PP2Cc_SM00332 99-429 1.4e-47 155.4 In-house 40-274 (274) alignment 
Range on Protein: 99-429
Range on HMM: 40-274/274.0
YACFGVFDGHAGEGASLMAVNTLHIHIMEKLSSVKELLtcksdeklalspqlaeavvssisiDKLVIGALEEAFFEMDEQIRRERNTYRI---TGGCTAV
 . |||||||.|. .. .. . |. .. |.|...|. |                        .. |  ||..|| ..||.|. | .  .    . |.|||
wlffgvfDGhgGsevakfvskklpealkeelkkkkdel........................eddveealkkaflstdeeileeeqskelenalsGstav

VALFLGKKLYVANAGDSRAIVSQKGKLIELSMDFTP--ETERRRLQLIAYqkphllgsefgrlefqqrarkkfvgqkllyrdrhmsgwahkivteedaqk
|||. ...|||||.|||||.....|| ..|| | .|  |.||.|..  ..                                                  
vallkkedlyvanvGDSravlcrngkavqlsvdhkpedederkRikkagg..................................................

fpmitgEGKKARLLDTIGTTRGFGDHDLKVPYcnLSIKPFLTPEPEVMTYDLtqckHDEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTpkhDKRRYVV
        .| |. ...  .| ||||.|| .    . .|..|.||.| . .|     .||..||.|.||||. |.| .. .|| .  .|.    . ..  
......vvekgrvngglavsrafGdhflkknk..klkepyitaepdvkvvtl....tsedeflilaSDGlwdvlsnqevvdivrkllakg...ktndpqe

AAQTLVAEAKGVltekgwrracgeMGSYDDITAFVI
||. |..||                ||.|.||..|.
aaelldeeairr............ggseDniTvvvv
subfamily_PPM1G2_pd Subfamily PPM1G2 99-238 2.6e-23 75.4 In-house 52-163 (287) alignment 
Range on Protein: 99-238
Range on HMM: 52-163/287.0
YACFGVFDGHAGEGASLMAVNTLHIHIMEklssvkelltcksdeklalspqlaeavVSSISiDKLVIGALEEAFFEMDEQIRRERNTYRITGGCTAVVAL
 | |.||||| |. .. .| . |.  |..                            .| . .  .  .|..|| |.||........   . |.||||.|
lalfavfDGhGGakvakyagkklikkiak...........................kksfk.egaleqilkdafletDeellkdeklkdesaGstavvvl

FLGKKLYVANAGDSRAIVSQKGKLIELSMDFTPETERRRL
   .||||||||||||..|.||..  ||.|  |..|  . 
ikeeklyvanaGDsravlsskgnvkalsfDhkPqeesekk
subfamily_PPM1A_pd Subfamily PPM1A 99-237 2.6e-21 69.2 In-house 42-164 (282) alignment 
Range on Protein: 99-237
Range on HMM: 42-164/282.0
YACFGVFDGHAGEGASLMAVNTLHIHIMEklssvkelltcksdeklalSPQLAEAVVSSISiDKLVIGALEEAFFEMDEQIRRERNTYRI--TGGCTAVV
 . | |||||||. .. .. ..|. .|.|                   . .| ||  .. . .. |  ||...|...||.||.. ....     |.|||.
wsfFavfDGHaGsevakyvkkhllenile...................eeelkeaalease.kdevkealrqgfLaldeairelstdlktadksGsTavt

ALFLGKKLYVANAGDSRAIVSQKGKLIELSMDFTPETE--RRR
.|   |.|..||.|||||.....|| . |. |  |...  ..|
vlvsekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkR
subfamily_TAB1_pd Subfamily TAB1 99-234 9.4e-14 43.9 In-house 28-176 (333) alignment 
Range on Protein: 99-234
Range on HMM: 28-176/333.0
YaCFGVFDGHAGEGASLMAVNTLHIHIMEKL-S------SVKELLTCKSD-EKLALSPQLAEAVVSSISIDKLVIGAL--EEAFFEMDEQIRRERN-TYR
.  ..||||. |. |. .. ..|  ... .  .       ||| |. . .  .  .  .. .|.    .. . .   .   |.. . .|.| | .. .  
i.lyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverkflesiddalaekddlqsqlPegvssyeleeqypekierlqeleee

ITGGCTAVVALFLGKKLYVANAGDSRAIVSQ---KGKLIELSMDFTPETE
|.|| |||||| . .||||||.|||||.. .   . |   ||.| | . |
isgGttAvvalifnnkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNe
subfamily_PP2D1_pd Subfamily PP2D1 99-177 1.3e-07 23.7 In-house 33-127 (492) alignment 
Range on Protein: 99-177
Range on HMM: 33-127/492.0
YACFGVFDGHAGEGASLMAVNTLHIHIMEKLSSVKELLTCKSDEKLALSPQLAEA-------------VVSSISID---KLVIGALEEAFFEMDE
 . ||..||. |  |  .| ..||  ..|.|..| | ... ....|.   .|..              .  . |..   . |  |..... ..|.
scFfgiyDGynGataAeiaakelhevlleelekvdervslttavnlidnndltdyelerasrsdsirailkeesvkpefekvkkAfrksylrldr
subfamily_ILKAP_pd Subfamily ILKAP 100-387 1.7e-17 56.5 In-house 44-250 (293) alignment 
Range on Protein: 100-387
Range on HMM: 44-250/293.0
ACFGVFDGHAGEGASLMAVNTLHIHIMEKLSSvKELLTCKsdeklalspqlaeavvssISIDKlvigALEEAFFEMDEQIRR--ERNTYRITGGCTAVVA
. ..|||||||. ||  | ..|| .|.|||.. ... . .                   .| |    .| ..| . ||.  .  ....     |.||.| 
syyavfdGhaGsrasefaaeklhkkileklpk.sdvsake..................keikk....clvdsfkktdeefLklaskakPvWkdGstatvv

LFLGKKLYVANAGDSRAIVSQK---GK---LIELSMDFTPEterrrlqliayqkphllgsefgrlefqqrarkkfvgqkllyrdrhmsgwahkivTEEDA
| | . ||||| |||.|.. .|   |.    . |. | ||                                                       ..|. 
lvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpv......................................................kyeer

QKFPMITGEGKKARLLDTIGTTRGFGDHDLKvpYCNLsikpflTPEPEVMTYDLTqckhDEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPKHD
..     |  .. |.|  .. .|  ||   |   . .      .  |.|.  .||    . |  ...| ||||. ... .... . .|...  ...
kriqkaGgvvrdgrvlGvlevsrsiGdgrfk..rlGv......istPdvkkceLt....endlfvvlaCdGLwkvfsadevvkfilkvledeeddr
subfamily_KAPP-like_pd Subfamily KAPP-like 100-234 1.1e-09 30.7 In-house 35-148 (266) alignment 
Range on Protein: 100-234
Range on HMM: 35-148/266.0
ACFGVFDGHAGEGASLMAVNTLHIHIMEKLSSvkelltcksdeklalspqlAEAVVSSISIDKlVIGALEEAFFEMDEQIRRERntYRitgGCTAVVALF
| |.||||||| ||.  | . .   . ..| |                   ..      .| .   . ||.|| |.|....     |    |.|| .|| 
alfavfdGhaGkGaadaakklfpkelekllks...................tkqddGGdniyd.qskllenafkevdaklkdfe..ye...Gatatlalv

L--GKK--LYVANAGDSRAIVSQKGKLIELSMDFTPETE
   |..  | ||| ||| |..|.  . .|||.|   . .
wsdGqqrylqvanvGdssaflsrGneslelskdhkakdp
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 100-230 4.3e-07 22.1 In-house 34-154 (276) alignment 
Range on Protein: 100-230
Range on HMM: 34-154/276.0
ACFGVFDGHAGEGASLMAVNTLhIHIMEK-LSSVKELLTCKSDEklalspqlAEAvvsSISIDklviGALEEAFFEMDEQIRRerNTYRitgGCTAVVAL
| |.||||||| ||.  | . .  ...|| | | .  || . |          .             . | ..| |.|....     |    |.|| .||
alfavfdGhaGkGaadaakklf.pkelekllksgnysltkqddG........Gdn...iydqs....kllldlfkevdaklkd..feye...Gatatlal

FLGKK----------LYVANAGDSRAIVSQKGKLIELSMDFT
   .           | ||| ||| |..|.  . .|||.|  
vwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhk
PPM_PTC7_SpoIIE 101-386 3.4e-18 59.3 In-house 36-213 (230) alignment 
Range on Protein: 101-386
Range on HMM: 36-213/230.0
CFGVFDGHAGEGASLMAVNTlhihimeklSSVKEL-----LtcksdeklalspqlaeavvssisidkLVIGALEEAFFEMDEQIRRErntyRITGGCTAV
 .|..||| |  |  |.            . ..||                                ..  .|.... ... ... |     ...|.|||
vvgdvdGhGgraalamgllr.........talrelafagle..........................kpeeilrrlnlalaadlede....psssgaTav

VALFLGKK--LYVANAGDSRAIVSQK-GKlielsmdftpeterrrlqliayqkphllgsefgrlefqqrarkkfvgqkllyrdrhmsgwahkIVTEEDAQ
|||. . .  |||||||||....... |.                                                                ..  .| 
validpstgklyvanaGdsppllvrddgg...............................................................ererivag

KFPMiTG---EgkkaRLLDTIGTTRGFGDHDLKVpycnlsiKPFLT-PEPEvmtyDLTQCKHDEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTpkH
 .|.  |   .    |  ..   .. .||  |.        . ... .||.    . .    ..|. ||.|.||||..|..  ....| . . |   .
glps.lGilpg....rvfgvlavslapGdlllly.......tDGvveaepd....tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp..a
subfamily_PDP_pd Subfamily PDP 101-220 6.2e-10 31.7 In-house 27-182 (398) alignment 
Range on Protein: 101-220
Range on HMM: 27-182/398.0
CFGVFDGHAGEGASLMAVNTLHIHIMEKLSSVKELLTC----KSDEKL------------ALSPQLAEAVV--------SSISID-KLVIGALEEAFFEM
 |||||||.|  ..    . |  ..  .| . ..| .     .|...|              | . ..  .        . .... . |  ||..|| ..
lfgvfDGHggaacaeavskrLlkyvaasllkkqvleeaekalesgkallkllkkskhkldvvsdeakklslselskylqelleaevekvkealkkaFlkl

DEQIRRERN-----TY------RITGGCTAVVALFLGKKLYVANAGDSRAIVSQKG
|..|. |       .         . | .|..||  |..|.|||.||.||.. .. 
DkdistealkklkekslreallvalsGacallaliegtelhvAntGDcravlgvqe
PP2C_SIG_SM00331 102-429 5.4e-13 42.0 In-house 33-215 (217) alignment 
Range on Protein: 102-429
Range on HMM: 33-215/217.0
FGVFDGHA-GEGASLMAVNTLHiHIMEKLSSVkelltcksdeklalsP---------------QlaeavvssisidklvigaleeaffemdeqirrernT
. |.||.  |  |....  ...  ..| ||.                                .                                   .
lvvaDgmGkGlaAaaassqlrt.alrellseg...............eelsqalkrlnraiyee...................................k

YRITGGCTAVVAL--FLGKKLYVANAGDSRAIVSQKGKLIELSMDftpeterrrlqliayqkphllgsefgrlefqqrarkkfvgqkllyrdrhmsgwah
    ...|...||  | ..||..||||||| .. ..|||.|   |                                                       
eekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd.......................................................

kivteedaqkfpmitgegkkarlldtigttrgfgdhdlkvpycnlSIKPFLTPEPEVMtYDLTQCKHDEDDVLIIATDGLWEKLT----NLKALEIVAEV
                                                . |  ||||. .| .. . ...|.|...||||.|. .    . . || . | 
.............................................vegaplGlepevs.vdirelelekgdllllytDGltearsekgfaeerleeiled

FQKTPKHDKRR-YVVAAQTLVAEAKGvltekgwrracgemgsYDDITAFVI
...... .  .  |  . .|.....|                 ||||  |.
lvdseaqelaqkiveellelakgsng................eDdiTvvvv
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 166-239 3.3e-11 35.9 In-house 75-145 (255) alignment 
Range on Protein: 166-239
Range on HMM: 75-145/255.0
GALEEAFFEMDEQIrrerNTYRITGGCTAVVALFLGKKLYVANAGDSRAIVSQK-GKLIELSMDFTPETERRRLQ
 .|..|. |.. ||    . . .  |.||...|....| |.|| ||||....|| |    ||.|  |  |. ...
kslkkaykeistqi....serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekr
subfamily_PPM1K_pd Subfamily PPM1K 168-236 6.1e-11 34.9 In-house 71-145 (263) alignment 
Range on Protein: 168-236
Range on HMM: 71-145/263.0
LEEAFFEMDEQIRRERNT-----YRITGGCTAVVALF-LGKKLYVANAGDSRAIVSQKGKLIELSMDFTPETERR
| .|| |.|....|  .         . | || |.|.  |..| .|. ||||||. ..||   |. | .|| |  
lknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleee
subfamily_PPM1G_pd Subfamily PPM1G 189-236 1.4e-15 50.3 In-house 295-342 (473) alignment 
Range on Protein: 189-236
Range on HMM: 295-342/473.0
TGGCTAVVALFLGKKLYVANAGDSRAIVSQKGKLIELSMDFTPETERR
  |.||||||  .|||.||||||||...|..|| ..||.|  || |  
dsGttAvvaLlkekklivAnaGDsRcvlsrnGkAldlslDHkPeDevE
subfamily_PPM1A_pd Subfamily PPM1A 278-429 3.9e-11 35.8 In-house 149-278 (282) alignment 
Range on Protein: 278-429
Range on HMM: 149-278/282.0
MSGWAHKIVTEEDAQKFPMITGEGKKARLLDTIGTTRGFGDHDLKVPYCNLSIKPFLTPEPEVMTYDltqcKHDEDDVLIIATDGLWEKLTNLKALEIVA
..   ||  .... ..     |.  . |.  ..  .| .||...|      . .  ...||||.. .    ...||| |..| ||.|. |.. ...|.|.
flteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekkaeeqlvsaepevtsie....rseeddflvlacDGiwDvlsdeevvelvr

EVFQKTPKHDKRryvvaaqtlvaeakgvltEKGWRRACGEMGSYDDITAFVI
. .... .  .                    |   . . | || | ... |.
krlevadeleev..................akalvdkalekgsrDNlsvlvv
subfamily_PPM1G2_pd Subfamily PPM1G2 282-387 4.9e-07 22.0 In-house 153-254 (287) alignment 
Range on Protein: 282-387
Range on HMM: 153-254/287.0
AHKIVTEEDAQKFPMITGEGKKARLLDTIGTTRGFGDHDLKVPYCNLSIKPFLTPEPEVMTYDLTqckhDEDDVLIIATDGLWEKLTNLKALEIVAEVFQ
 ||  .|.....     |  .  |  ...   | .||.  |      .     | .|.|.. .|.    ..|. |..| ||.|. ||| . ...| | ..
DhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkld....eddeflvLaCDGiWDvltnkevvdlvrerlv

KTPKHD
.  | |
sgakld
subfamily_PP2D1_pd Subfamily PP2D1 297-392 3.5e-07 22.3 In-house 233-318 (492) alignment 
Range on Protein: 297-392
Range on HMM: 233-318/492.0
ITGEGKKARLLDTIGTTRGFGDHdlkvpyCNLSIKPFLTPEPEVMTYDLTQckhdEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPKHDKRRYV
.. ..|...    ..|||| | .       .. .|  . |||.. .  |..    .. .|..|. |||| |..   |..| ....   .. ..  |
vvkseknglvnGildttRGLGny......GdpkLkksvipePkttsvklde....aaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvraenv
PP2C Protein phosphatase 2C 299-390 2.3e-13 43.3 Pfam-A 156-234 (255) alignment 
Range on Protein: 299-390
Range on HMM: 156-234/255.0
GEGK-KARLLDTIGTTRGFGDHDLKVPYcnlsiKPFLTPEPEVMtydLTQCKHDeDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPkhdkrR
|. . . |. ...  .| .||..||  .     ... ..||.|     .. . . |. ||.|.||||..|.. .| ..| .  .|.       
gsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvt...svkltee.defliLasdGlwdvlsdqeavdlvrselskkk.....s
PP2C Protein phosphatase 2C 299-390 2.3e-13 43.3 In-house 156-234 (255) alignment 
Range on Protein: 299-390
Range on HMM: 156-234/255.0
GEGK-KARLLDTIGTTRGFGDHDLKVPYcnlsiKPFLTPEPEVMtydLTQCKHDeDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPkhdkrR
|. . . |. ...  .| .||..||  .     ... ..||.|     .. . . |. ||.|.||||..|.. .| ..| .  .|.       
gsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvt...svkltee.defliLasdGlwdvlsdqeavdlvrselskkk.....s
PPM_PTC7 302-402 1.1e-12 41.0 In-house 160-250 (259) alignment 
Range on Protein: 302-402
Range on HMM: 160-250/259.0
K---KARLLDTIGTTRGFGDHDLKVPYCnlsIKPFLTPEPEVMtydLTQCKHDeDDVLIIATDGLWEKLTNLKALEIVAEVFQKTpkhdkrRYVVAAQTL
    . |. ...  .| |||..||  .     .. ...||..     |.   . |. ||.|.||||..... .| ..| ....|.          ||. |
snvgngrvngvlavsRafGdfelkpket...eeqlvsaePdis...stkidee.defliLasdGlwdvvsdqeavdlvrselskk......dpmeaaekl

VAEA
| ||
vdea
subfamily_KAPP-like_pd Subfamily KAPP-like 303-388 2.7e-07 22.9 In-house 165-240 (266) alignment 
Range on Protein: 303-388
Range on HMM: 165-240/266.0
KARlLDTIGTTRGFGDHDLKVPYCNLSIKPFLTPEpevmtYDLTQckhdEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPKHDK
..| .. .  .| .||| .|   . |. .|.....     . ||      |. ||.|.||||. ..  .|.|.|  ....   .||
qtr.inGlavsralGdhfikelniGlisepyvsnr.....illtp....fdkflivasdGlwdvisGkdaiekvkslydqqatedk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 308-388 4e-07 22.2 In-house 179-250 (276) alignment 
Range on Protein: 308-388
Range on HMM: 179-250/276.0
DTIGTTRGFGDHDLKVPYCNLSIKPFLTPEpevmtYDLTQckhdEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPKHDK
. .  .| .||| .|   . |. .|.....     . ||      |. ||.|.||||. ..  .|.|.|  ....   .||
nGlavsralGdhfikelniGlisepyvsnr.....illtp....fdkflivasdGlwdvisGkdaiekvkslydqqatedk
subfamily_PPM1L_pd Subfamily PPM1L 309-381 1.3e-07 24.1 In-house 175-237 (269) alignment 
Range on Protein: 309-381
Range on HMM: 175-237/269.0
TIGTTRGFGDHDLKvpycNlsiKPFLTPEPEVMTYDLTQCKhdeDDVLIIATDGLWEKLTNLKALEIVAEVFQ
 . |.| .||. ||    .   | .. ..|...|.|| . |    . ||.|.||||. ..| .|.. . | ..
vlatsralGdyplk....d...knlviadpdiltfdlddhk...peflilasdGlwdtfsneeavrfikerlk
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 327-380 6.5e-08 25.2 In-house 174-224 (255) alignment 
Range on Protein: 327-380
Range on HMM: 174-224/255.0
NLSIKPFLTPEPEVMTydlTQCKHDEDDVLIIATDGLWEKLTNLKALEIVAEVF
.  ..||..|.|..     .  .. .|  ||.| ||.|. ... .| ||||.. 
dsflePfvvpdPdlsq...sleiskkdkflilacdGiwdlisdeeaveivagis
subfamily_PPM1E_pd Subfamily PPM1E 329-403 4.5e-08 25.6 In-house 181-247 (265) alignment 
Range on Protein: 329-403
Range on HMM: 181-247/265.0
SIKPFLTPEPEVMTYDLTqckhDEDDVLIIATDGLWEKLTNLKALEIVAEVFQKtPKHDkrrYVVAAQTLVAEAK
. ||... |..|....|.    .....||.|.||||. ... .....| | ... ...|   .  .|..||..||
klkpyvsgeadvaeveld....gseeylilacDGlwDvvneeevvklveeflad.gaed...lsevakllveaak
subfamily_PDP_pd Subfamily PDP 331-390 6.5e-11 34.9 In-house 267-322 (398) alignment 
Range on Protein: 331-390
Range on HMM: 267-322/398.0
KPFLTPEPEVMTYDLTQckhdEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPKHDKRR
 |.|| ||||... |..    .|  |..||||||. |.| .. ..| | ..|. .... .
PPYltaePevtshklre....ndkFLvlatDGLwdllsneevvslVgehlakkkekepvk
subfamily_PPM1D_pd Subfamily PPM1D 334-404 2.5e-07 23.1 In-house 222-288 (309) alignment 
Range on Protein: 334-404
Range on HMM: 222-288/309.0
LTPEPEVMTYDLTqckHDEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPKHDKRRyVVAAQTLVAEAKG
  |||.|. . |.    .|....|.|.||||. ||  .| ..| .  .|.  ....     |..|| || .
vsPePdvkvrtld...pneekfiilasDGlwnvltpedavsvvekeeekkelkeeqs.rsvakalvkealq
SpoIIE Stage II sporulation protein E (SpoIIE) 339-429 5.7e-06 18.3 Pfam-A 111-190 (193) alignment 
Range on Protein: 339-429
Range on HMM: 111-190/193.0
EvMTYDLTQCKHDEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPKHDKRRYVVAAQTLVAEAKGvltekgwrraCGEMGSYDDITAFVI
| ..|. .... ...|.|...|||. |  .  . |   ..  .   .. ...    ...||.|..           .|. .  |||| .|.
e.adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle..........lgsgeleDDitllvl
SpoIIE Stage II sporulation protein E (SpoIIE) 339-429 5.7e-06 18.3 In-house 111-190 (193) alignment 
Range on Protein: 339-429
Range on HMM: 111-190/193.0
EvMTYDLTQCKHDEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPKHDKRRYVVAAQTLVAEAKGvltekgwrraCGEMGSYDDITAFVI
| ..|. .... ...|.|...|||. |  .  . |   ..  .   .. ...    ...||.|..           .|. .  |||| .|.
e.adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle..........lgsgeleDDitllvl
PPM_PTC7_SpoIIE_motif 343-429 1.3e-08 28.4 In-house 2-78 (81) alignment 
Range on Protein: 343-429
Range on HMM: 2-78/81.0
YDLTQCKHDEDDVLIIATDGLWEKL---TNLKALEIVAEVFQKTpkhDK-RrYVVAAQTLVAEAKGvltekgwrraCGEMGSYDDITAFVI
|| ....  ..|||...||||.|     ..|.. | .......    .. .    .|..||.|..           .|.... |||| .|.
ydeaefqLkpgdvllLyTDGltEardsdgelfgkeellrladra...egks.lqeladklvdevle..........ngsgereDDitllvl
subfamily_PPTC7_pd Subfamily PPTC7 346-405 2.3e-06 20.2 In-house 160-215 (252) alignment 
Range on Protein: 346-405
Range on HMM: 160-215/252.0
TQCKHDEDDVLIIATDGLWEKLTNLKALEIVAEVFQKTPKhdkrRYVVAAQTLVAEAKGV
.. .  ..|....|||||.  |.. . |||..|. .....    .  ..|..|...|. .
ksfavkkgDiivlatDGlfDNlledeileilkelkeseks....slqslakklaekarel
PPM_PTC7_motif 357-402 4.9e-06 19.9 In-house 1-42 (51) alignment 
Range on Protein: 357-402
Range on HMM: 1-42/51.0
IIATDGLWEKLTNLKALEIVAEVFQKTPKhdkrRYVVAAQTLVAEA
|.|.||||..|.. .| ..| .   |. .    ..  ||. || ||
iLAsDGLWDvlsdqeavdlvrdqlskkgl....spqeaAeklvdea