Gene PPM1K-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1K
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP148_AA protein Get Run
NvecP148_AA_86-351 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 87-351 1.8e-68 223.4 In-house 19-293 (295) alignment 
Range on Protein: 87-351
Range on HMM: 19-293/295.0
SIDSVGFNSLQGKKSVNEDRFKLLE----LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRL-------HRDGENDLEEILVQAFEECDTELKRHLEHl
 . .||. | ||... |||..  .     |..|...|.||||||| . ||.|.. |.|....|       . . ..|.||.|..|| ..| || ..... 
lllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall.

vsekgeDLSELSSGTTATVVLLRDGTdLAIASTGDSRAVLCRNGETSCITRDHHPSLEEEQQRILSCNGRIEStssdlLRVNGRLAMTRSLGDFDLK---
      . . . |||||.|.|.|... | .| .|||||||.||||  ..|.||.|. |.|..||||..|..        |||| ||.||.|||||||   
......rpelagsGtTavvalirgnk.lyvanvGDSravllrngelvqltvdhkpvnelererilsaggavsh.....grvngvlavtRalGdfdlklll

-----PYGVIATPDTKLLKVDHNADAFIVLITDGISDVISSYELGFLVRM----CTDPEQAAHSLTCCAMQYGSDDNVTAVVVPLRAW
     ...|.|.||.. |..... | |..| .||..||.|. |.  .||     ..|.|.||. |.  |...|| ||.|.||| |. .
slllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvvvvrlngl
PP2Cc_SM00332 87-346 1.2e-57 188.4 In-house 8-274 (274) alignment 
Range on Protein: 87-346
Range on HMM: 8-274/274.0
SIDSVGFNSLQGKKSVNEDRFKLL-EL--DPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDGEN----DLEEILVQAFEECDTELKRHLEHLVSEK
.  | |..| ||... .||..    .|    |. .|.||||||| . |.|. .||.|.. .     ..    | ||.| .||...| |.  . . .  |.
lglsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen

gedlseLSSGTTATVVLLRDGTdLAIASTGDSRAVLCRNGETSCITRDHHPSLEEEQQRILSCNGRIESTssdllRVNGRLAMTRSLGDFDLK------P
       .||.||.|.||.... | .|..|||||||||||.   ...||.|. |.| .|| . .| .|       |||| ||..|..||..||      .
......alsGstavvallkked.lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekg.....rvngglavsrafGdhflkknkklke

YGVIATPDTKLLKVdHNADAFIVLITDGISDVISSYELGFLVRMCT------DPEQAAHSLTCCAMQY-GSDDNVTAVVV
 ...|.||.| ...  ..| |..|..||. ||.|. |.  .|| .       ||..||  |. .|... || ||.|.|||
pyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvvv
subfamily_PPM1K_pd Subfamily PPM1K 88-353 6.6e-142 464.2 In-house 3-263 (263) alignment 
Range on Protein: 88-353
Range on HMM: 3-263/263.0
IDSVGFNSLQGKKSVNEDRFKLLELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLHrDGENDLEEILVQAFEECDTELKRHLEHLVSEKgedlSELS
..|||..||.||...||||.||.||||...|.||||||.|...|.|.||||..|..||. ..|.|||..|..||||.|..|||.||..|.|.    ..||
lesvGkdsliGkraenedriklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaea....ells

SGTTATVVLLRDGTDLAIASTGDSRAVLCRNGETSCITRDHHPSLEEEQQRILSCNGRIESTSSDLLRVNGRLAMTRSLGDFDLKPYGVIATPDTKLLKV
|||||||.||||||.|..||.|||||.|||||.....||||.|.||||..||....|..|..|.. ..|||||||||||||.|||.|||||||.||.|||
sGttatvsllrdGtelvlaslGdsrailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkv

DHNADAFIVLITDGISDVISSYELGFLVRMCTDPEQAAHSLTCCAMQYGSDDNVTAVVVPLRAWRK
||.||.|.||||||||.|..|.||..|||.|.|||.|||.||..|.||||.||.|||||||.||.|
dhaadsflvlitdgisfvvnsqelcdlvrlchdpeeaahalteqalqygsednatavvvplgawgk
0049733 PP2C-like 90-348 1.3e-55 181.2 In-house 4-233 (235) alignment 
Range on Protein: 90-348
Range on HMM: 4-233/235.0
SVGFNSLQGK-KSVNEDRFKLleldpDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRL-HRDGENDLEEILVQAFEECDTELKRHLEHLVsekgedlSELS
|||. | .|. ..||||.. .     ....|||.|||||   .|.| . |.|....| ..  . ||||.|..||......| .. ..         .   
svgaasdigrvrkvneDavlv.....glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalasp.......elag

SGTTATVVLLRdGTDLAIASTGDSRAVLCRNGETSCITRDHHPSLEEEQQRILSCNGRIestssdllRVNGRLAMTRSLGDFDLKpygviatPDTKLLKV
.||||.|.||. |  | .|. |||||.|.|.|.  ..|.||.|. |.|.|||....|..        ||.||||.||.|||..||       ||.  |..
mgtTavvalld.ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav........rvpgrlaltralGdlllk.......pdvtvlel

DHNAdaFIVLITDGISDVISSYELGFLVRMcTDPEQAAHSLTCCAMQYGSDDNVTAVVVPL
...   |..| .||..||.|. |.  |.|  .|.|.||. |.  |...|. ||.|.||| |
epgd..flllasDGlwdvlsdeeivdllrs.ldleeaaerlvelalarggrDNiTvvvvrl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 90-348 1.5e-46 151.7 In-house 7-253 (255) alignment 
Range on Protein: 90-348
Range on HMM: 7-253/255.0
SVGFNSLQGKKSVNEDRFKLL---ELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDGENDLEEILVQAFEECDTELkrhlehlvSEKGedlseL
 |||  . |...  ||.. .    . ..|  |.|.|||||| ..|.|| ..|. |.. |    . . ...| .|..| .| .        ||..      
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqi........serp.....k

SSGTTATVVLLRDgTDLAIASTGDSRAVLC-RNGETSCITRDHHPSLEEEQQRILSCNGRIESTsSDLLRVNGRLAMTRSLGDFDLKPYgVIATPDTKLL
  ||||..||. .     ||  ||||.||| ..| .  .. ||.|| |.|..||    | . ||     |||| ||..|.|||  |.|. |.. || .  
fiGttaasvliie.dkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvst.vvtsrvnGtlavsralGdsflePf.vvpdPdlsqs

KVDHNADAFIVLITDGISDVISSYELGFLVRMCTDPEQAAHSLTCCAMQYGSDDNVTAVVVPL
   .. | |..|  ||| |.||  |   .|   .|||.||  |   | . ||.||.. .|. |
leiskkdkflilacdGiwdlisdeeaveivagisdpekaaeklrdlayssGstdnisvivikl
subfamily_PPM1G2_pd Subfamily PPM1G2 90-346 3e-44 144.1 In-house 20-284 (287) alignment 
Range on Protein: 90-346
Range on HMM: 20-284/287.0
SVGFNSLQGKKSVNEDRFKL----LE--LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDGENDLEEILVQAFEECDTELKRHlehlvsekgEDL
 ||  ..|| .   ||   |    ||   |..  .||||||||| . |..|  ||.... . .   |. ||.|| .|| |.|.|| ..         | |
kvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkd.........ekl

SELSSGTTATVVLLRDGTdLAIASTGDSRAVLCRNGETSCITRDHHPSLEEEQQRILSCNGRIESTssdllRVNGRLAMTRSLGDFDLKPYG--------
.. |.|.||.|||...   | .| .|||||||. .|... ...|| |. |.|..||   .| .|       |||| ||. |.||||  |           
kdesaGstavvvlikeek.lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfveln.....rvngnLalsralgDfefkknvkkkpeeqi

VIATPDTKLLKVDhNADAFIVLITDGISDVISSYELGFLVRMC----TDPEQAAHSLTCCAMQYGSD------DNVTAVVV
| |.||  . |.| . | |.||  ||| ||... |.  |||      ..... ...|   ...  |.      ||.|.|.|
vtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvviv
subfamily_PPM1G_pd Subfamily PPM1G 90-170 4.8e-13 41.9 In-house 20-101 (473) alignment 
Range on Protein: 90-170
Range on HMM: 20-101/473.0
SVGFNSLQGKKSVNEDRFK-LLELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDGENDLEEILVQAFEECDTELKR
|.|. . || .  .||  . ...|| |   |||.|||||   |..  .|| ....  .   |.|.|. | .|| ..|..|| 
sygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklka
subfamily_PPM1A_pd Subfamily PPM1A 91-348 6.5e-52 169.6 In-house 14-280 (282) alignment 
Range on Protein: 91-348
Range on HMM: 14-280/282.0
VGFNSLQGKKSVNEDRFKLL---ELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRR--------LHRDGENDLEEILVQAFEECDTELKRHLEHLVSE-
.| .| || .. .||...     .  .|  .|||||||.| . |......|.| . .        |... .....| | |.| . | ..... ..| .. 
ygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeairelstdlktad

KGedlselssGTTATVVLLRdGTDLAIASTGDSRAVLCRNGETSCITRDHHPSLEEEQQRILSCNGRIEstssdLLRVNGRLAMTRSLGDFDLKP-----
|         |.||..||..  . | ||  |||||||||||..   |.|| || ..|..||    | .        |||| ||..|.|||...|      
ks........GsTavtvlvs.ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvv.....vsRvnGaLAvsRalGDyeykeeeekk

---YGVIATPDTKLLKVDHNADaFIVLITDGISDVISSYELGFLVRMC----TDPEQAAHSLTCCAMQYGSDDNVTAVVVPL
     |.| |... .. ... | |.||  ||| ||.|. |.  |||      ...|. |..|   |.. || ||....|| .
aeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf
PP2C Protein phosphatase 2C 92-341 2.4e-54 177.6 Pfam-A 4-255 (255) alignment 
Range on Protein: 92-341
Range on HMM: 4-255/255.0
GFNSLQGKKSVNEDRFKLLE------LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDGEN-DLEEILVQAFEE-CDTELKRHLEHlvsekgeDl
|...||| .. .||.  .|.       . .. .|||||||||   |..|. .|.||. .   . |  ..|..| ..|..  | |||.. ..       . 
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskan.......t.

SELSSGTTATVVLLRDGTdLAIASTGDSRAVLCRNGETS-CITRDHHPSLEEEQQRILSCNGRIEStssdLLRVNGRLAMTRSLGDFDLKP---YGVIAT
....||.||.|.|.|. . | .| .|||||||||....   .|.||.|| |.| .|| . .|...       |||| ||..|.||||.|||   . |.| 
epsksGstavvalirgkk.lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn....ngrvngsLavsRalGdfelkpkeeqlvsae

PDTKLLKVDHNaDAFIVLITDGISDVISSYELGFLVRMCTD----PEQAAHSLTCCAMQYGSDDNV
||..  | . . | |..| .||. ||.|. |.  ||| . .    |..||  |   |...|| ||.
Pdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
PP2C Protein phosphatase 2C 92-341 2.4e-54 177.6 In-house 4-255 (255) alignment 
Range on Protein: 92-341
Range on HMM: 4-255/255.0
GFNSLQGKKSVNEDRFKLLE------LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDGEN-DLEEILVQAFEE-CDTELKRHLEHlvsekgeDl
|...||| .. .||.  .|.       . .. .|||||||||   |..|. .|.||. .   . |  ..|..| ..|..  | |||.. ..       . 
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskan.......t.

SELSSGTTATVVLLRDGTdLAIASTGDSRAVLCRNGETS-CITRDHHPSLEEEQQRILSCNGRIEStssdLLRVNGRLAMTRSLGDFDLKP---YGVIAT
....||.||.|.|.|. . | .| .|||||||||....   .|.||.|| |.| .|| . .|...       |||| ||..|.||||.|||   . |.| 
epsksGstavvalirgkk.lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsn....ngrvngsLavsRalGdfelkpkeeqlvsae

PDTKLLKVDHNaDAFIVLITDGISDVISSYELGFLVRMCTD----PEQAAHSLTCCAMQYGSDDNV
||..  | . . | |..| .||. ||.|. |.  ||| . .    |..||  |   |...|| ||.
Pdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni
subfamily_PPM1L_pd Subfamily PPM1L 92-349 2.5e-38 124.9 In-house 8-267 (269) alignment 
Range on Protein: 92-349
Range on HMM: 8-267/269.0
GFNSLQGKKSVNEDRFKLLELD---PDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDGENDLEEILVQAFEECDTELKRHLEHLVSEKGEDlSELSS
   |..|..   ||||.. |      .  .|||||||||  .||||.|.| . ...   . ..| |. .  .|..  |.    ... . || .  .|  .
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakr.aedia

GTTATVVLLRDgTDLAIASTGDSRAVLC-RNGETSCITRDHHPSLEEEQQRILSCNGRIESTSSdlLRVNGRLAMTRSLGDFDLKPYG-VIATPDTKLLK
|||| . |... .|| .|  |||| ||. ..|..  .. ||.|   .|..|| .  | |    .   ||.| ||..|.|||. ||    |||.||   ..
Gttalialvqe.sdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGv..wrvaGvlatsralGdyplkdknlviadpdiltfd

VDHNADAFIVLITDGISDVISSYE-LGFLVRMCTDPEQAAHSLTCCAMQYGSDDNVTAVVVPLR
.|.    |..| .||. | .|  | . |.     .|.  |.||.  . . || ||.| .|| |.
lddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvklk
Subfamily Dicty-PPM1L-like 93-143 9.7e-07 20.9 In-house 11-64 (305) alignment 
Range on Protein: 93-143
Range on HMM: 11-64/305.0
FNSLQGKKSVNEDRFKL---LELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVR
 .  ..... .||| |    || . . ..| |||||.|  .||... || ||| 
lyvsansrkyqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivn
PPM_PTC7 94-341 2.7e-53 174.0 In-house 6-259 (259) alignment 
Range on Protein: 94-341
Range on HMM: 6-259/259.0
NSLQGKKSVNEDRFKLLE------LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDGEN-DLEEILVQAFEECDTELKRHLehlvS--EkgeDlS
.. || .. .||.  .|        . .. .|||||||||   |..|. .|.||. .  .. |  .||..|  .|...||. .  .    |      .  
safqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelks....sean...t.e

ELSSGTTATVVLLRDGTdLAIASTGDSRAVLCRNGETS-CITRDHHPSLEEEQQRILSCNGRIESTssDLLRVNGRLAMTRSLGDFDLKP-----YGVIA
...||.||.|.|... . | .| .|||||||||.|..    |.||.||.|.| .|| . .|....   .  |||| ||..|..|||.|||       |.|
pstsGstAvvalitgsk.lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnv..gngrvngvlavsRafGdfelkpketeeqlvsa

TPDTKLLKVDHNaDAFIVLITDGISDVISSYELGFLVRMCTD---PEQAAHSLTCCAMQYGSDDNV
.||..  | | . | |..|..||. ||.|. |.  ||| . .   |. ||  |   |...|| ||.
ePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni
PP2C_2 Protein phosphatase 2C 96-320 2.9e-15 49.1 Pfam-A 5-197 (212) alignment 
Range on Protein: 96-320
Range on HMM: 5-197/212.0
LQGKKSVNEDRFKlLELDPDFYYFAVFDGHGGVSS----AEFAHDKLHEIVRRLHRDGEND-LEEILVQAFEECDTELKrhleHLVSEKGEDLSELSSGT
 . |.....|..     . |. ..|| ||.|  .     |..|   . | ...|. ... .  |..|.|. .|.....|    .  ... .. .  . .|
hrrkgkpcqDala.ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk....lkqeaeaqqeelkdyat

TATVVLlRDGTDLAIASTGDSRA-VLCRNGETSCITRDHHPSLEEEQQRILSCNGRIEStssdllrvngrlamtrslgdfdlkpygviatpdtKLLKVDH
| .... .... ..... ||... |  |.||. ... ...   . | ... | .   |                                   .. ... 
Tlllav.itpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..................................rirrlkl

NADAFIVLITDGISDVISSYE--LGFLVRMCTD
..   ..| |||.|| ....|    .| ...  
epgdalllmTDGvsdslrkeepfrellaellet
PP2C_2 Protein phosphatase 2C 96-320 2.9e-15 49.1 In-house 5-197 (212) alignment 
Range on Protein: 96-320
Range on HMM: 5-197/212.0
LQGKKSVNEDRFKlLELDPDFYYFAVFDGHGGVSS----AEFAHDKLHEIVRRLHRDGEND-LEEILVQAFEECDTELKrhleHLVSEKGEDLSELSSGT
 . |.....|..     . |. ..|| ||.|  .     |..|   . | ...|. ... .  |..|.|. .|.....|    .  ... .. .  . .|
hrrkgkpcqDala.ireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvk....lkqeaeaqqeelkdyat

TATVVLlRDGTDLAIASTGDSRA-VLCRNGETSCITRDHHPSLEEEQQRILSCNGRIEStssdllrvngrlamtrslgdfdlkpygviatpdtKLLKVDH
| .... .... ..... ||... |  |.||. ... ...   . | ... | .   |                                   .. ... 
Tlllav.itpgeivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..................................rirrlkl

NADAFIVLITDGISDVISSYE--LGFLVRMCTD
..   ..| |||.|| ....|    .| ...  
epgdalllmTDGvsdslrkeepfrellaellet
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 99-282 5.6e-28 91.3 In-house 3-196 (292) alignment 
Range on Protein: 99-282
Range on HMM: 3-196/292.0
KKSVNEDRFKLLE-LDPDFYYFAVFDGHG--GVSSAEFAHDKLHEIVRRLHRDgENDLEEILVQAFEECDTElkrhLEHLVSEKGEdlselSSGTTATVV
 |  |.||| |.|  ..  .  ||.||||  |   |..| |.|   .  | |.   .| | |..   .  ..    |..|  ...|     |..|...  
nkkenqdrfllvegsealtflaavldGhGvnGdkvaqlaedtlevelleltrq.lqelsealllrildiaak....ldkltidare.....sattavvca

LLRDGTDLAIASTGDSRAVLCR-----NGETSCITRDHHPSLEEEQQRILSCNGRIESTS------SDLLRV------NGRLAMTRSLGDFDLKPYGVIA
  ||.  | .|  |||||.| |     . |   ..|||.|.  .|..|||   ||.| |           ||      .| ||..|.|||| |.  ||.|
rvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvva

TPDT
 |. 
ePel
PP2C_SIG_SM00331 99-347 6.5e-19 61.3 In-house 13-216 (217) alignment 
Range on Protein: 99-347
Range on HMM: 13-216/217.0
KKSVNEDRFKLLELDPDFYYFAVFDGHG-GVSSAEFAHDKLHEIVRRLHRDgendleEILVQAFEECDTELKRHlehlvsekgedLSELSSGTTATVVLL
 ..| .| . ...|. . . ..|.||.| |. .|...   .. .   |...      | |.||.....  ...              | ....|... |.
atqvsGDyydvvklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg......eelsqalkrlnraiyee...........keekgmfaTlllaly

-RDGTDLAIASTGDSRAVLCRNGETSCITRDhhpsleeeqqrilscngriestssdllrvngrlamtrslgdFDLKPYGVIATPDTKLLKVDHNADAFIV
   .  | .|. |||| .| |.|..  |. |                                            .| |.. ... .  ... ... ...
dfssgklsyanaGdsrpyllrdgklveilkd.........................................vegaplGlepevsvdirelelekgdlll

LITDGISDVIS-----SYELGFLVRMC--TDPEQAAH----SLTCCAMQYGSDDNVTAVVVP
| |||. .. |      ..|  ... .  . ... |.    .|   | ...  |..| ||| 
lytDGltearsekgfaeerleeiledlvdseaqelaqkiveellelakgsngeDdiTvvvvk
subfamily_TAB1_pd Subfamily TAB1 99-180 8.5e-09 27.6 In-house 10-94 (333) alignment 
Range on Protein: 99-180
Range on HMM: 10-94/333.0
KKSVNEDRFKLLELDPDFYYFAVFDGHGGVSSAEFAHDKLHE--IVRRLHRDG-ENDLEEILVQAFEECDTELKRHLEHLVSEKG
..  .||.. |.. . | . .|||||. | ..|.|....|    .   |  .  | . .|.| .|||| . .. ....... || 
edhevedkvflfktendpilyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverkflesiddalaekd
subfamily_PPM1H_pd Subfamily PPM1H 107-146 1.4e-06 20.3 In-house 53-92 (404) alignment 
Range on Protein: 107-146
Range on HMM: 53-92/404.0
FKLLELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLH
 |  |   ...||..||||.| . |  |  .||.....  
ekseeeklplayfglfDGhaGsgaalvaskllhkhlkekl
subfamily_PPM1E_pd Subfamily PPM1E 112-348 4.2e-49 160.1 In-house 36-262 (265) alignment 
Range on Protein: 112-348
Range on HMM: 36-262/265.0
LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDgENDLEEILVQAFEECDTELKRHlehLVSEkgedlsELSSGTTATVVLLRDGTdLAIASTGDS
 ...  .|||||||||| .|..|  .||| . | ... ..| .| | .||...|... ..    ..|      .| ||.|| |||..  . |..|  |||
dekeraffavfDGHgGveaakyaaahlhellvrqekl.kedpaealkeafkltDerflqk...aere......klksGstavvvliekdq.lyvaWlGDs

RAVLCRNGETSCITRDHHPSLEEEQQRILSCNGRIESTssDLLRVNGRLAMTRSLGDFDLKPYgVIATPDTKLLKVDHNADaFIVLITDGISDVISSYEL
.|.|.|.||.  ... |.|. |.|..|| . .| .  .  . .|||| |...|..|| .|||| |.. .|.  ...|.. . ...| .||..||.   |.
qallvrkgeavqlmkpHkPeredEkkRieeagGlvvvi..gawRvnGvLsvsRaiGDvklkpy.vsgeadvaeveldgsee.ylilacDGlwDvvneeev

G-----FLVRMCTDPEQAAHSLTCCAMQYGSDDNVTAVVVPL
      || .  .| ...|..|   | . ||.||.|.||| |
vklveefladgaedlsevakllveaakeagssDnitvvvvfl
subfamily_PPM1D_pd Subfamily PPM1D 113-320 1.8e-30 99.1 In-house 32-266 (309) alignment 
Range on Protein: 113-320
Range on HMM: 32-266/309.0
DPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRR---LHRDGENDLEEILVQAFEECDTELKRHLEHLVSEKGEDLSelSSGTTATVVLLRdGTDLAIASTG
. .. ..||||||||   |.||...| . ...   .  . ..|. | . .|| .. ...|..||. . .|  .||   .||||.||..| ...| .|  |
elevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksglls..taGttasvviir.reklyvahvG

DSRAVLCRNGE------TSCITRDHHPSLEEEQQRILSCNGRIESTsSDLLR---------VNGR--------LAMTRSLGDF-----DLKPYGVIATPD
||..||  . .      ....|.||.|.  ||..|| .. |..    | . |          ||.        ||..|||||.       . . |   ||
DsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak.sGvkRvvWkRprlehngptvideiPFLavaRslGDlWsynaksgefvvsPePd

TKLLKVDHNADAFIVLITDGISDVISSYELGFLVRMCTD
.|  ..| | . ||.| .||. .|... .   .|.    
vkvrtldpneekfiilasDGlwnvltpedavsvvekeee
PPM_PTC7_SpoIIE 113-311 2.5e-25 82.6 In-house 31-201 (230) alignment 
Range on Protein: 113-311
Range on HMM: 31-201/230.0
DPDFYYFAVFDGHGGVSsaEFAHDKLHEIVRRLHrDGEND-LEEILVQAFEECDTELKRHlehlvsekgedlsELSSGTTATVVLLRDGT-DLAIASTGD
.  . .....||||| .   .|.  |....|.|  . . . .||||  ........|.               . |||.||.|.|..  |  | .|. ||
grlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede.............psssgaTavvalidpstgklyvanaGd

SRAVLCRNGETscitrdhhpsleeEQQRIlSCNGRIEsTSS--DllRVNGRLAMTRSLGDFDLKP--YGVIATPDtKLLKVDHNADAFIVLITDGISDVI
|...|.|....             |  ||    | ..  .   .  ||.| ||.... ||. |..    | | ||    . . . |.|..|..||. || 
sppllvrddgg.............ereri.vagglps.lGilpg..rvfgvlavslapGdllllytDGvveaepd.tsdgelfgkdeflilasdglwdvl

SSYEL
|. ||
spqel
subfamily_ILKAP_pd Subfamily ILKAP 117-310 7.5e-31 100.4 In-house 44-234 (293) alignment 
Range on Protein: 117-310
Range on HMM: 44-234/293.0
YYFAVFDGHGGVSSAEFAHDKLHE-IVRRLHRDG----ENDLEEILVQAFEECDTELkrhLEHlvseKGEDLSELSSGTTATVVLLRDGTdLAIASTGDS
 |.||||||.|  ..||| .|||. |...| ..     |...   ||..|.. | |.   |.       ..      |.||||||  | . | .|  |||
syyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeef...Lkl....askakPvWkdGstatvvlvldnv.lyvanlGds

RAVLCRNGETS------CITRDHHPSLEEEQQRILSCNGRIESTssdllRVNGRLAMTRSLGDFDLKPYGVIATPDTKLLKVDHNaDAFIVLITDGISDV
.|||.|. | .      ..|.||.|  .||..||  . | ..       ||.| | ..||.||   |  |||.|||.| .....| | |.||  ||. .|
kavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdg.....rvlGvlevsrsiGdgrfkrlGvistPdvkkceLten.dlfvvlaCdGLwkv

ISSYE
.|  |
fsade
subfamily_KAPP-like_pd Subfamily KAPP-like 118-347 1.4e-22 73.0 In-house 36-265 (266) alignment 
Range on Protein: 118-347
Range on HMM: 36-265/266.0
YFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDGENDleeilvqAFEECDTELKRHLEHLVSEKGEDLSEL-SSGTTATVVLL-RDGTD--LAIASTGDSRA
 ||||||| |  .|. |.. . ... .| .  ..|          .   . .. || ...|  . |..    |.|||..|. .||    | .|  ||| |
lfavfdGhaGkGaadaakklfpkelekllkstkqd.......dGGdniydqskllenafkevdaklkdfeyeGatatlalvwsdGqqrylqvanvGdssa

VLCRNGETSCITRDHHPSLEEEQQRILscNGRIEsTSSDLLRVNGrLAMTRSLGDFDLKP--YGVIATPDTKLLKVDHNADAFIVLITDGISDVISSYEL
 |.|  |.  .. ||.   .||.|||   .  |   | .  |.|| ||..|.|||  .|    |.|..|      .    | |... .||. ||||  . 
flsrGneslelskdhkakdpeekqrik..ddGit.lsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdvisGkda

GFLVRMCTDPEQAAHSLTCC----AMQ-YGSDDNVTAVVVP
   |.   | ........ .    |.|   . |||. .|| 
iekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 118-347 6.9e-21 67.3 In-house 35-275 (276) alignment 
Range on Protein: 118-347
Range on HMM: 35-275/276.0
YFAVFDGHGGVSSAEFAHDKLHEIVRRLHRDGENDLEEIlvQAFEECDTELKRHLEHLVSEKGEDLSELS-SGTTATVVLL-RDG--------TDLAIAS
 ||||||| |  .|. |.. . ... .| . |.  | .   .   .   . .. | .| .|  . |..    |.|||..|. .||          | .| 
lfavfdGhaGkGaadaakklfpkelekllksgnysltkq..ddGGdniydqskllldlfkevdaklkdfeyeGatatlalvwsdGeeqqqqqqrylqvan

TGDSRAVLCRNGETSCITRDHHPSLEEEQQRILscNGRIEsTSSDLLRVNGrLAMTRSLGDFDLKP--YGVIATPDTKLLKVDHNADAFIVLITDGISDV
 ||| | |.|  |.  .. ||. .  ||.|||   .  |   | .  |.|| ||..|.|||  .|    |.|..|      .    | |... .||. ||
vGdssaflsrGneslelskdhkatdpeekqrik..ddGit.lsdnqtrinG.lavsralGdhfikelniGlisepyvsnrilltpfdkflivasdGlwdv

ISSYELGFLVRMCTDPEQAAHSLTCC----AMQ-YGSDDNVTAVVVP
||  .    |.   | ........ .    |.|   . |||. .|| 
isGkdaiekvkslydqqatedkmasslletaiqsikakdnvsvivvk
subfamily_PDP_pd Subfamily PDP 148-272 2.2e-14 46.4 In-house 110-241 (398) alignment 
Range on Protein: 148-272
Range on HMM: 110-241/398.0
DGENDLEEILVQAFEECDTEL-KRHLEHLVSEKGED-LSELSSGTTATVVLLrDGTDLAIASTGDSRAVLCRNGETS---C--ITRDHHPSLEEEQQRIL
   ....| | .||...| .. .  |..| ... .. |    ||..|...|. .||.| .|.|||.||||... |..   .  ...|.  . ||| .|| 
aevekvkealkkaFlklDkdistealkklkekslreallvalsGacallali.egtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRik

SCNGRIES-TSSDLLRVNGRLAMTRSLGDFDLK
.     || |     |. |.|. .|  ||. .|
keHPgeesktvirngRlLgeLqPlRAFGdvryK
subfamily_PPM1H_pd Subfamily PPM1H 159-240 1.5e-08 26.8 In-house 142-211 (404) alignment 
Range on Protein: 159-240
Range on HMM: 142-211/404.0
QAFEECDTELKRHLEHlvsekgedlSELSSGTTATVVLLRDGtDLAIASTGDSRAVLCRNGETSCITRDHHPslEEEQQRIL
.|| |.|  ..|  |.          ... | || |.|. .|  | .|  |||||.|.|..|.  . .|. |  | |.||..
saflemDeqiarerea.........yrikGGCtalvalvllg.klYvanaGDsRailvrkdeiiplsadftP..eteRqRlq
subfamily_PPM1G_pd Subfamily PPM1G 175-311 8e-27 87.3 In-house 283-421 (473) alignment 
Range on Protein: 175-311
Range on HMM: 283-421/473.0
LVSEKGEDLSELSSGTTATVVLLRDgTDLAIASTGDSRAVLCRNGETSCITRDHHPSLEEEQQRILSCNGRIESTssdlLRVNGRLAMTRSLGDFDLK--
| ......    .|||||.|.||..  .| .|  ||||.||.|||.   .  || |  |.|..||    |....     .|||| | . | |||.  |  
ldgseekeepGedsGttAvvaLlke.kklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvded....gRvnGGLnlsRAlGDhaYkkn

------PYGVIATPDTKLLKVDhNADAFIVLITDGISDVISSYEL
         . | || | |..  ..| |.|| .||| .|..| | 
eeLplkeqmisAlPDikvltlt.eedeFlvlAcDGiWnvmesqev
subfamily_Choan-PPM-1_pd Subfamily Choan-PPM-1 177-347 7.6e-12 37.0 In-house 123-314 (317) alignment 
Range on Protein: 177-347
Range on HMM: 123-314/317.0
SEKGEDLSELSSGTTATVVLLRDGTDLAIASTGDSRA-V-LCR-------NG-ETSCITRDHHPSLEEEQQRILSCNGRIE-STSSDLLRVN------GR
| .. . . |  ||||.| .. | | ...| .||. | | | .       .| .   ... |    ..|..|. .  .     |  . | ..       .
srddvptrPldfGttavvavvvdethvvvanaGdaaalvllrdqaghedrdGlsvealsvrhtlrskaerarvaevlpgaahvtedgylaildealaaye

LAMTRSLGDFDLKPYGVIATPDTKLLKVDHNADAFIVLITDGISDVISSYE-LGFLVRMCTDPEqAAHSLTCCA----MQYGSDDNVTAVVVP
| .|.|||   || .|||| |. .   .| .    .| ..|||.| ..  . |  ..| .|  | |.. |   |    ..  | |..||||. 
lqltkslGhkllkraGviadPevrsrvldvdevfavvvvsdGitdelkrldvldrvlraatale.asevlcddaqdylldetsiddatavvll
subfamily_TAB1_pd Subfamily TAB1 185-284 2.2e-08 26.3 In-house 126-238 (333) alignment 
Range on Protein: 185-284
Range on HMM: 126-238/333.0
ELSSGTTATVVLLRDgTDLAIASTGDSRAVLCR---NGETSCITRDHHPSLEEEQQRILSCNGRIESTSSdlLRVNGRLAMTRSLGDFDLKP--------
|.| |||| |.|.    .| .|  |||||.|..   . .   .  ||.   |.| .|.      ||   .   .. |    |||.||. .|         
eisgGttAvvalifn.nkLyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikr..nkrlgskentRsiGdykvkkgykdvdil

-----YGVIATPDTKL
       |||.|| . 
ssakgePviaePdiqg
subfamily_PP2D1_pd Subfamily PP2D1 192-316 1.2e-21 70.1 In-house 179-303 (492) alignment 
Range on Protein: 192-316
Range on HMM: 179-303/492.0
ATVVLLRDGTDLAIASTGDSRAVLCRNGETSCITRDHHPSLEEEQQRILSCNGRIESTsSDLLRVNGRLAMTRSLG---DFDLKpYGVIATPDTKLLKVD
.. | |   . | || .|. .|||||.|.. ..||.| |  ..| .|.    . . ..     .||| |  || ||   | .||   ||  | |.  |.|
gsevhleelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvks.eknglvnGildttRGLGnyGdpkLk.ksvipePkttsvkld

hNADAFIVLITDGISDVISSYELGFLVR
 .|. |.|| . |. .|.|  |   ||.
.eaaqflvlAsnGlWevlseeevlsLvk
Subfamily Dicty-PPM1L-like 197-268 4.5e-09 28.6 In-house 223-294 (305) alignment 
Range on Protein: 197-268
Range on HMM: 223-294/305.0
LRDGTDLAIASTGDSRAVLCRNGETSCITRDHHPSLEEEQQRILSCNGRIESTSSDLLRVNGRLAMTRSLGD
  |   | .| ..|.. ||...|    .  .. .   .| .|. | ...||    .. || . .|. |  ||
nndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavkrgsgD
subfamily_PHLPP_pd Subfamily PHLPP 202-348 3e-14 45.5 In-house 106-245 (246) alignment 
Range on Protein: 202-348
Range on HMM: 106-245/246.0
DLAIASTGDSRAVLCRNGETSCITRDHHPSLEeEQQRILSCNGRIESTSsdllRVNGRLAMTRSLGDFDLKPYgVIATPDTKLLKVDHNaDAFIVLITDG
 | .||.|   |||.|||.   ... .  . . | .||   .. |.  .    ..|| .. || || . | |. |. .|  . ... .. | ....  . 
sLevAsvGtlqavliRngkklrlsksyviekd.elkrikeakaiitedn....kingviestrllGytflfPv.vlPkphvrevlLteq.dellivGnka

ISDVISSYELGFLVRMCTDPEQAAHSLTCCAMQYGSDDNVTAVVVPL
. .|.|  |.   ||   ||  ||  |.  |  || .|.|...|| |
lWevlsideaveavrkeedplvaAkklvdlaqsygaadsvsvlvvrl
Subfamily Dicty-PPM1L-like 254-311 2e-08 26.5 In-house 199-255 (305) alignment 
Range on Protein: 254-311
Range on HMM: 199-255/305.0
LRVNGRLAMTRSLGDFDLKPYgVIATPDTKLLKVDHNADAFIVLITDGISDVISSYEL
|.||. |   || || .|| . ||  .| .|| | .  | |.|| |||. .|.|  ..
llvnrllkksrskGdknlkel.viPnndspllvvakanDqflvlatdGlwevlsyqdv
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 281-338 2.7e-06 20.1 In-house 236-291 (292) alignment 
Range on Protein: 281-338
Range on HMM: 236-291/292.0
DTKLLKVDHNADAFIVLITDGISDVISSYELGFLVRMctDPEQAAHSLTCCAMQYGSD
| || |  .. |||.|| .||. ||... |.  |.     .| |.. .|  |..||. 
drklekeldsddaflvlasdGvldvllnaevvlllak..sqeaadkvitelaleygls
PPM_PTC7_motif 296-341 1.8e-06 21.4 In-house 1-51 (51) alignment 
Range on Protein: 296-341
Range on HMM: 1-51/51.0
VLITDGISDVISSYELGFLVRMCTD-----PEQAAHSLTCCAMQYGSDDNV
.| .||. ||.|..|.  ||| . .     |..||  |   |...||.||.
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni