Gene PPM1K-2 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1K
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP149_AA protein Get Run
NvecP149_AA_86-180 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 87-174 6e-16 51.4 In-house 19-117 (295) alignment 
Range on Protein: 87-174
Range on HMM: 19-117/295.0
SIDSVGFNSLQGKKFVNEDRFKLLE----LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRR-------MHRDGENDLEKILVQAFEECDTELKRHLEY
 . .||. | ||..  |||..  .     |..|...|.||||||| . ||.|.. |.|....       .. . ..|.|..|..|| ..| || .... 
lllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelall
subfamily_PPM1K_pd Subfamily PPM1K 88-183 6.4e-41 133.2 In-house 3-97 (263) alignment 
Range on Protein: 88-183
Range on HMM: 3-97/263.0
IDSVGFNSLQGKKFVNEDRFKLLELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHrDGENDLEKILVQAFEECDTELKRHLEYLVSEKDTQE
..|||..||.||. .||||.||.||||...|.||||||.|...|.|.||||..|..|.. ..|.|||..|..||||.|..|||.||..|.|.....
lesvGkdsliGkraenedriklkeldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaells
PP2Cc_SM00332 89-172 2.5e-11 36.5 In-house 10-100 (274) alignment 
Range on Protein: 89-172
Range on HMM: 10-100/274.0
DSVGFNSLQGKKFVNEDRFKLL-EL--DPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGEN----DLEKILVQAFEECDTELKRHL
 | |..| ||..  .||..    .|    |. .|.||||||| . |.|. .||.|.. .     ..    | |..| .||...| |.  . 
lsygkssmqgwrksmeDahvvvvdlveeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileee
subfamily_PPM1G2_pd Subfamily PPM1G2 90-172 3.8e-13 42.0 In-house 20-108 (287) alignment 
Range on Protein: 90-172
Range on HMM: 20-108/287.0
SVGFNSLQGKKFVNEDRFKL----LE--LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGENDLEKILVQAFEECDTELKRHL
 ||  ..|| ..  ||   |    ||   |..  .||||||||| . |..|  ||.... . .   |. ||.|| .|| |.|.|| .. 
kvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdafletDeellkde
0049733 PP2C-like 90-174 5.4e-13 42.1 In-house 4-85 (235) alignment 
Range on Protein: 90-174
Range on HMM: 4-85/235.0
SVGFNSLQGK-KFVNEDRFKLleldpDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRM-HRDGENDLEKILVQAFEECDTELKRHLEY
|||. | .|. . ||||.. .     ....|||.|||||   .|.| . |.|..... ..  . |||..|..||......| .. . 
svgaasdigrvrkvneDavlv.....glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelala
subfamily_PPM1G_pd Subfamily PPM1G 90-170 8.9e-13 41.0 In-house 20-101 (473) alignment 
Range on Protein: 90-170
Range on HMM: 20-101/473.0
SVGFNSLQGKKFVNEDRFK-LLELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGENDLEKILVQAFEECDTELKR
|.|. . || .  .||  . ...|| |   |||.|||||   |..  .|| ....  .   |.|.|| | .|| ..|..|| 
sygasamqGwrvsqEDahncitdldedtslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalDeklka
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 90-170 4.3e-09 29.0 In-house 7-90 (255) alignment 
Range on Protein: 90-170
Range on HMM: 7-90/255.0
SVGFNSLQGKKFVNEDRFKLL---ELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGENDLEKILVQAFEECDTELKR
 |||  . |..   ||.. .    . ..|  |.|.|||||| ..|.|| ..|. |.. .    . . .|.| .|..| .| .. 
kvgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqise
subfamily_PPM1A_pd Subfamily PPM1A 91-167 7.4e-10 31.6 In-house 14-101 (282) alignment 
Range on Protein: 91-167
Range on HMM: 14-101/282.0
VGFNSLQGKKFVNEDRFKLL---ELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRR---M-----HRDGENDLEKILVQAFEECDTE
.| .| || .  .||...     .  .|  .|||||||.| . |......|.| . .   .     ... ...... | |.| . | .
ygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldea
PP2C Protein phosphatase 2C 92-172 4.3e-09 29.3 Pfam-A 4-92 (255) alignment 
Range on Protein: 92-172
Range on HMM: 4-92/255.0
GFNSLQGKKFVNEDRFKLLE------LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGEN-DLEKILVQAFEE-CDTELKRHL
|...||| .  .||.  .|.       . .. .|||||||||   |..|. .|.||. .   . |  ..||.| ..|..  | |||.. 
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelkssk
PP2C Protein phosphatase 2C 92-172 4.3e-09 29.3 In-house 4-92 (255) alignment 
Range on Protein: 92-172
Range on HMM: 4-92/255.0
GFNSLQGKKFVNEDRFKLLE------LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGEN-DLEKILVQAFEE-CDTELKRHL
|...||| .  .||.  .|.       . .. .|||||||||   |..|. .|.||. .   . |  ..||.| ..|..  | |||.. 
gaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelkssk
subfamily_PPM1L_pd Subfamily PPM1L 92-155 2.5e-08 26.5 In-house 8-74 (269) alignment 
Range on Protein: 92-155
Range on HMM: 8-74/269.0
GFNSLQGKKFVNEDRFKLLELD---PDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGENDLEK
   |..|..   ||||.. |      .  .|||||||||  .||||.|.| . ...   . ..| |.
avysvlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknklieldadken
PPM_PTC7 96-169 3.8e-09 29.3 In-house 8-90 (259) alignment 
Range on Protein: 96-169
Range on HMM: 8-90/259.0
LQGKKFVNEDRFKLLE------LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDGEN-DLEKILVQAFEECDTE--LK
 || .  .||.  .|        . .. .|||||||||   |..|. .|.||. .  .. |  .|||.|  .|...||.  ||
fqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelk
subfamily_TAB1_pd Subfamily TAB1 99-184 2.7e-08 26.0 In-house 10-98 (333) alignment 
Range on Protein: 99-184
Range on HMM: 10-98/333.0
KKFVNEDRFKLLELDPDFYYFAVFDGHGGVSSAEFAHDKLH-EIVR-RMHRDG-ENDLEKILVQAFEECDTELKRHLEYLVSEKDTQEP
..  .||.. |.. . | . .|||||. | ..|.|....|  |..   .  .  | . ...| .|||| . .. .... .. |||  . 
edhevedkvflfktendpilyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverkflesiddalaekddlqs
PP2C_SIG_SM00331 100-171 2.2e-06 20.4 In-house 14-80 (217) alignment 
Range on Protein: 100-171
Range on HMM: 14-80/217.0
KFVNEDRFKLLELDPDFYYFAVFDGHG-GVSSAEFAHDKLHEIVRRMHRDgendleKILVQAFEECDTELKRH
. | .| . ...|. . . ..|.||.| |. .|...   .. .   ....      . |.||.....  ... 
tqvsGDyydvvklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg......eelsqalkrlnraiyee
Subfamily Dicty-PPM1L-like 102-144 4.3e-06 18.7 In-house 20-65 (305) alignment 
Range on Protein: 102-144
Range on HMM: 20-65/305.0
VNEDRFKL---LELDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRR
 .||| |    || . . ..| |||||.|  .||... || ||| .
yqedrnkvkislessqelslfGvfdGhnGdiaaeyvkkklveivnk
subfamily_PPM1E_pd Subfamily PPM1E 112-170 1.4e-11 37.1 In-house 36-93 (265) alignment 
Range on Protein: 112-170
Range on HMM: 36-93/265.0
LDPDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRDgENDLEKILVQAFEECDTELKR
 ...  .|||||||||| .|..|  .||| . | ... ..| .. | .||...|... .
dekeraffavfDGHgGveaakyaaahlhellvrqekl.kedpaealkeafkltDerflq
subfamily_PPM1D_pd Subfamily PPM1D 114-176 2.6e-08 26.3 In-house 33-98 (309) alignment 
Range on Protein: 114-176
Range on HMM: 33-98/309.0
PDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRM---HRDGENDLEKILVQAFEECDTELKRHLEYLV
 .. ..||||||||   |.||...| . ...      . ..|. . . .|| .. ...|..||  .
levafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWp
subfamily_PPM1H_pd Subfamily PPM1H 114-148 2e-06 19.8 In-house 60-94 (404) alignment 
Range on Protein: 114-148
Range on HMM: 60-94/404.0
PDFYYFAVFDGHGGVSSAEFAHDKLHEIVRRMHRD
 ...||..||||.| . |  |  .||.....  .|
lplayfglfDGhaGsgaalvaskllhkhlkekled
subfamily_ILKAP_pd Subfamily ILKAP 117-168 3.6e-08 25.9 In-house 44-100 (293) alignment 
Range on Protein: 117-168
Range on HMM: 44-100/293.0
YYFAVFDGHGGVSSAEFAHDKLHE-IVRRMHRDG----ENDLEKILVQAFEECDTEL
 |.||||||.|  ..||| .|||. |.... ..     |... | ||..|.. | |.
syyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeef