Gene PTC7-1 in Nematostella vectensis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PTC7
Protein sequence
ID Type Fasta BLAST phosphatome Note
NvecP150_AA protein Get Run
NvecP150_AA_39-297 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 40-297 3.6e-30 97.9 In-house 19-291 (295) alignment 
Range on Protein: 40-297
Range on HMM: 19-291/295.0
CGFSKDYHTSKKRFAFGEDAYFITENLFS-----NVLGVADGVGGWRQYGIDSSLFSSQLMQSCQRFVKEGRLSALSPIAIIKNAFQEL--------TEL
. ..  ... . |    |||...  ||.|      ..||.||.||..   . |.|. . |.. .....    ||  ... ....||...         . 
lllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieealrkaflaadeellelallr

KASVFGSSTACIVVLdkKDKTLLSVNLGDSGFLVVRKGIVVHQSSEQQHYFNTPYQLAIPPPGqdgRVIQDSLD--------------------------
.   ....||.....  ....|   |.||| ....|.| .|. . .. ..... ..  . . |   .|. . .                           
pelagsGtTavvali..rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsagg...avshgrvngvlavtRalGdfdlklllsllllepl

-----AAESTSFNVEVDDLIVMGTDGLFDNLSTDQILTEIAELQDyDAESiqsladslamkarclafdpsyesPFAKQAKLRGLAITGGKPDDITVLVAV
        ......| ||......|||.|.|| ..|.. ...|      .                       . .   .|  ||. .|. |.|||.|. 
vsaePdvtvleltledddfllLasDGlwdvlsneeivdivrslla.kgld.......................leeaaeeLvdlAlargsrDNiTvvvvr

VS
..
ln
PP2Cc_SM00332 45-174 5.6e-08 25.5 In-house 13-149 (274) alignment 
Range on Protein: 45-174
Range on HMM: 13-149/274.0
DYHTSKKRFAFGEDAYFITENL----FSNVLGVADGvggwrQYGIDSSLFSSQLMQSCQRFVKEGRLS--ALSPIAIIKNAFQELTELKASVF-------
 .......   .|||.... .|    .  . ||.||     . | . . | |. . ..    ... ..    .. ...|.||... |             
gkssmqgwrksmeDahvvvvdlveeedwlffgvfDG.....hgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileeeqskelen

GSSTACIVVLDKKDKTLLSVNLGDSGFLVVRKGIvVHQSSEQQ
 .| .. ||   |...|   |.|||   ..|.|  ..| |...
alsGstavvallkkedlyvanvGDSravlcrngk.avqlsvdh
PP2C_SIG_SM00331 46-294 1.4e-23 76.6 In-house 7-215 (217) alignment 
Range on Protein: 46-294
Range on HMM: 7-215/217.0
YHTSKKRFAFGEDAYFITENLF-SNVLGVADGVGgwrqYGIDSSLFSSQLMQSCQRFVKEGrlsaLSPIAIIKNAFQELTELKASVFGSSTACIVVLDKK
.. ..   ....| |.....   . .| ||||.|     |......|||| .  . ...||     ..  ..|.. . . |.|    .  |... ..| .
aqyyeeatqvsGDyydvvklnegrlllvvaDgmG....kGlaAaaassqlrtalrellseg....eelsqalkrlnraiyeekeekgmfaTlllalydfs

DKTLLSVNLGDSGFLVVRKGIVVHQSSEqqhyfNTPYQLAIPPPGQdgrviqdsldaAESTSFNVEVDDLIVMGTDGLFDNL-----STDQILTEIAELQ
...|  .|.||| ....|.|  |.. ..     .....| . |  .           ........| .||... ||||...       .... . ...|.
sgklsyanaGdsrpyllrdgklveilkd.....vegaplGlepevs...........vdirelelekgdllllytDGltearsekgfaeerleeiledlv

DYDAESIQS-LADSLAMKARCL-AfdpsyespfakqaklrglaitggkPDDITVLVA
|  |. ...   ..|  .|.                            .|||||.| 
dseaqelaqkiveellelakgsng........................eDdiTvvvv
subfamily_PPTC7_pd Subfamily PPTC7 49-297 1.9e-112 367.7 In-house 5-252 (252) alignment 
Range on Protein: 49-297
Range on HMM: 5-252/252.0
SkKRFAFGEDAYFITENLFSNVLGVADGVGGWRQYGIDSSLFSSQLMQSCQRFVKEGRLSALSPIAIIKNAFQELTELKASVFGSSTACIVVLDKKDKTL
. || ..||||||....  ..||||||||||||..|||.| ||..||..|....||.. ..|.|......|.|||.| |..|.||||||||||||.||.|
g.krqkageDayfvsseksadvlgvADGVggWrsvGiDpsefsreLmkaceklskeskaeelkPvelleaayqelleekvpvlGssTacivvldksdkkl

LSVNLGDSGFLVVRKGIVVHQSSEQQHYFNTPYQLAIPPPGQDGRVIQDSLDAAESTSFNVEVDDLIVMGTDGLFDNLSTDQILTEIAELQDYDAESIQS
 |.||||||||||||| ||..|.||||.|||||||.|.|.|..|.||.|. .||.|.||.|. .|.||..||||||||..|.||....||......|.||
esanlGDSgflvvRkgkvvfrskeqqhkfntPyQLsiapegregkvildkpeaadsksfavkkgDiivlatDGlfDNlledeileilkelkeseksslqs

LADSLAMKARCLAFDPSYESPFAKQAKLRGLAITGGKPDDITVLVAVVS
||..||.|||.|..||.||||||..|| .||...|||||||||.|||||
lakklaekarelsldpeyespfaqkakkngleasGGKpDDitvvvavvs
0049733 PP2C-like 50-296 5.7e-34 110.5 In-house 11-233 (235) alignment 
Range on Protein: 50-296
Range on HMM: 11-233/235.0
KKR-FAFGEDAYFItenlFSNVLGVADGVGGWRQYGIDSSLFSSQLMQSCQRfvkegrLSALSPIAIIKNAFQEL--------TELKASVFGSSTACIVV
..|    .|||...       ...||||.||..  .. |.|. . |.. ...      |. |........||...        .. .    . .||....
igrvrkvneDavlv....glllfavaDGhgghaagevasellvetllellle......lllldleealrkaflaaneallelalaspelagmgtTavval

LDkkDKTLLSVNLGDSGFLVVRKGIVVHQSSEQQHYFNTPYQLAIPPPGQD--------GRVIQDSLDAAESTSFNVEVDDLIVMGTDGLFDNLSTDQIL
||  ...|  .|.||| ....|.| .|. . ..........|  | . |           | . |.|  .. |....| .|.... .|||.|.|| ..|.
ld..ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggavrvpgrlaltralGdlllkpdvtvlelepgdflllasDGlwdvlsdeeiv

TEIAElqdydaESIQSLADSLAMKARClafdpsyespfakqaklrglaitGGKPDDITVLVAVV
  ...       ... .|. |.  |.                        .|..|.|||.|. .
dllrs......ldleeaaerlvelala.......................rggrDNiTvvvvrl
PPM_PTC7 51-176 3.7e-08 26.1 In-house 10-143 (259) alignment 
Range on Protein: 51-176
Range on HMM: 10-143/259.0
KRFAFGEDAYFITENLFSNvlgvaDGVGGWRQYGIDSSLFSSQLMQSCQ----RFVKEGRLSALS--PIAIIKNAFQE--LTELKAS-----VFGSSTAC
... . ||| ..  || |.     .|   ...... .. ..... . ..     ..|| .    .  ........|..  . | . |     .  .| ..
gfrksmedahialanless.....sgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsGst

IVVLDKKDKTLLSVNLGDSGFLVVRKGIVVHQSSEQQHY
.||.   ...|   |.|||.....|.| .|.| .|... 
AvvalitgsklyvAnvGDSravLcrsgnavkqltedHkp
PP2C_2 Protein phosphatase 2C 54-236 6.4e-10 31.7 Pfam-A 10-191 (212) alignment 
Range on Protein: 54-236
Range on HMM: 10-191/212.0
AFGEDAYFITENLFSNVLGVADGVGGWRQYGIDSSLFSSQLMQSCQRFVKEGRLS-ALSPIAIIKNAFQEL-------TELKASVFGSSTACIVVLDKKd
.. .||..| |.    .| ||||.|  ..  . . |. . .... .....|.... .   .  |.|. ...        . ....   .|...... .. 
kpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitp.

KTLLSVNLGDSGFLVVRKGIVVHQSSEQQ--HYFNTPYQLAIPPPGQDGrviqdsldaaESTSFNVEVDDLIVMGTDGLFDNLSTDQILTEIA
........||.. .|...   |.. .|..   | |. . |  . ....           .  ....|  | ... |||. |.|.... ..|. 
geivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..........rirrlklepgdalllmTDGvsdslrkeepfrell
PP2C_2 Protein phosphatase 2C 54-236 6.4e-10 31.7 In-house 10-191 (212) alignment 
Range on Protein: 54-236
Range on HMM: 10-191/212.0
AFGEDAYFITENLFSNVLGVADGVGGWRQYGIDSSLFSSQLMQSCQRFVKEGRLS-ALSPIAIIKNAFQEL-------TELKASVFGSSTACIVVLDKKd
.. .||..| |.    .| ||||.|  ..  . . |. . .... .....|.... .   .  |.|. ...        . ....   .|...... .. 
kpcqDalaireasdgwllaVADGaGsakrSdkGarlaveaagealeklleeeseqeeeallrqieneilasvklkqeaeaqqeelkdyatTlllavitp.

KTLLSVNLGDSGFLVVRKGIVVHQSSEQQ--HYFNTPYQLAIPPPGQDGrviqdsldaaESTSFNVEVDDLIVMGTDGLFDNLSTDQILTEIA
........||.. .|...   |.. .|..   | |. . |  . ....           .  ....|  | ... |||. |.|.... ..|. 
geivffqiGDgaivvrdrdgevqllgepdsgeyanettfltsedaeeel..........rirrlklepgdalllmTDGvsdslrkeepfrell
PPM_PTC7_SpoIIE 67-295 5.2e-15 48.9 In-house 31-228 (230) alignment 
Range on Protein: 67-295
Range on HMM: 31-228/230.0
FSNVLGVADGVGgwrqYGIDSSLFSSQLMQSCQRFVKEGRLsalSPIAIIKNAFQEL-TELKASV-FGSSTACIVVLDKKDKTLLSVNLGDSGFLVVRK-
 . .| |.|..|     |....|....| .  ... ..|      | .|.......| ..|. ..  . .||.....|  . .|  .|.||| .|.||. 
grlalvvgdvdG....hGgraalamgllrtalrelafagle...kpeeilrrlnlalaadledepsssgaTavvalidpstgklyvanaGdsppllvrdd

GIvvhqSSEQQHYFNTPYqLAIPPPgqdgrviqdslDAAESTSFNVEVDDLIVMGTDGLFDNL--STDQIL----TEIAELQDY------DAESIQSLAD
|       |.   .. |. |.| |              ......  .  ||... |||. ..   . | .|      .. . |       ..| .. . |
gg....ererivagglps.lGilpg...........rvfgvlavslapGdllllytDGvveaepdtsdgelfgkdeflilasdglwdvlspqelvdlvrd

SLAMKarclafdpsyespfakqaklrglAITGGKPDDITVLVAV
.|  .                       |  |.. ||||.||. 
elekp.......................aaeglleDDitllvvr
SpoIIE Stage II sporulation protein E (SpoIIE) 71-294 8.5e-17 53.6 Pfam-A 7-190 (193) alignment 
Range on Protein: 71-294
Range on HMM: 7-190/193.0
LGVADGVGgwrqYGIDSSLFSSQLMQSCQRFVKEGRLsalsPIAIIKNAFQEL-TELKASvFGSSTACIVVLDKKDKTLLSVNLGDSGFLVVRK-Givvh
|.|.|.||     |....|....| .  ......|      |  ..... . | ..|. .     ||.....| ....|  .|.|.. .|.||. |    
lvvgDvvG....hGleAalimgllrsalrelatagle....paevlerlnealarnleee.erfatavlaeydpstgkleyanaGhpppllvrpdg....

QSSEQQHYFNTPyqLAIPPPgqdgrviqdslDAAESTSFNVEVDDLIVMGTDGLFDNLSTDQIL----TEIAELQDYDAESIQSLADSLAMKARClafdp
.  .. . .. |  | | |              .|.... .| .||... |||.... . |. |      .| |..  .|| . |.|.|  ...      
gtkfllvstglp..lGilpe...........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle.....

syespfakqaklrglAITGGKPDDITVLVA
               .  |.. ||||.||.
...............lgsgeleDDitllvl
SpoIIE Stage II sporulation protein E (SpoIIE) 71-294 8.5e-17 53.6 In-house 7-190 (193) alignment 
Range on Protein: 71-294
Range on HMM: 7-190/193.0
LGVADGVGgwrqYGIDSSLFSSQLMQSCQRFVKEGRLsalsPIAIIKNAFQEL-TELKASvFGSSTACIVVLDKKDKTLLSVNLGDSGFLVVRK-Givvh
|.|.|.||     |....|....| .  ......|      |  ..... . | ..|. .     ||.....| ....|  .|.|.. .|.||. |    
lvvgDvvG....hGleAalimgllrsalrelatagle....paevlerlnealarnleee.erfatavlaeydpstgkleyanaGhpppllvrpdg....

QSSEQQHYFNTPyqLAIPPPgqdgrviqdslDAAESTSFNVEVDDLIVMGTDGLFDNLSTDQIL----TEIAELQDYDAESIQSLADSLAMKARClafdp
.  .. . .. |  | | |              .|.... .| .||... |||.... . |. |      .| |..  .|| . |.|.|  ...      
gtkfllvstglp..lGilpe...........adyeeaelqlepgdllllyTDGvtEardpdgelfgkerllallaeaegesleelldalveelle.....

syespfakqaklrglAITGGKPDDITVLVA
               .  |.. ||||.||.
...............lgsgeleDDitllvl
TSNR_N Thiostrepton-resistance methylase, N terminus 73-133 8.4e-06 12.1 Pfam-A 44-99 (115) alignment 
Range on Protein: 73-133
Range on HMM: 44-99/115.0
VADGVGGWRQYGIDSSLFSSQLMQSCQRFVKEGRLSAlspIAIIKNAFQelTELKASVFGS
.. ||     || ||. . |.|.. |..   . ||      .|. . |.  .| || ||| 
iragvefievygsdsvplpselldlcekreipvrlid...asivnqlfk..aerkakvfgi
PPM_PTC7_SpoIIE_motif 202-294 3.6e-09 30.2 In-house 2-78 (81) alignment 
Range on Protein: 202-294
Range on HMM: 2-78/81.0
AESTSFNVEVDDLIVMGTDGLFDNLsTDQILT-----EIAELQDYDAESIQSLADSLAMKARClafdpsyespfakqaklrglaiT--GGKPDDITVLVA
.....| .. .|.....||||...  .... .      .. ... ...| |.||| |  ...                       .  |.. ||||.||.
ydeaefqLkpgdvllLyTDGltEar.dsdgelfgkeellrladraegkslqeladklvdevle......................ngsgereDDitllvl
subfamily_PPM1H_pd Subfamily PPM1H 205-265 1.6e-06 20.1 In-house 317-381 (404) alignment 
Range on Protein: 205-265
Range on HMM: 317-381/404.0
TSFNVEVDDLIVMGTDGLFDNLSTDQILTEIAE-LQDYD---AESIQSLADSLAMKARCLAFDPS
|... . ||.....||||.| || ..... ..| |....    .   ..| .| ..||    | .
tqvesleDdvlilatDGLWdvlsneevaeivrevlskvepedkkrytavaqeLvaaarGklkdkg
PP2Cc_SM00332 210-293 3.8e-07 22.8 In-house 211-273 (274) alignment 
Range on Protein: 210-293
Range on HMM: 211-273/274.0
EVDDLIVMGTDGLFDNLSTDQILTEIAELQ----DYDAESIQSLADSLAMKArclafdpsyespfakqaklrglaitGGKPDDITVLV
. |..... .|||.|.|| ...   . .|     . |.. .. | | .|...                         ||. |.|||.|
sedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairr.........................ggseDniTvvv