Gene PTC4 in Saccharomyces cerevisiae

Synonym: GCT1, YBR125C, PTC4

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP005_AA protein Get Run
ScerP005_AA_26-370 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 27-370 5.4e-60 195.7 In-house 16-292 (295) alignment 
Range on Protein: 27-370
Range on HMM: 16-292/295.0
GIVPRFYNCVGSMQGYRLTQEDAHLIRN-----ENSvvyvrffnpfidkyetlsLNVFAVFDGHGGDDCSKFLSGGRHHRDG------------Ngssng
   .... .| |.||.| ..|||.|.       ...                  | .|.|||||||.......|   ..               .     
slllllrvgvasdqGrrksneDavlvvlnllslled..................lllfgvfDGhgGhaaaevasellvelllellekllllltls.....

ngepnaglikwiaysfenhhytsttnndsskfkrsfntlEGLVSQIFKDAFILQDEELYRHFAN----SSCGSTAVVACIiNEESLYVANCGDSRCILSs
                                       .  . .....||.  ||||.... .    . .|.||||| |  .. |||||.||||..|. 
.......................................ledieealrkaflaadeellelallrpelagsGtTavvali.rgnklyvanvGDSravll.

KSNGIKTMSFDHKPQHIGELIRINDNGGTVSLGRVGGVLALSRAFSDFQFKRGVTYphrrtkltnitqnltygtPPQEAQVTVEPDVLMHKIDYSKDEFL
... .. ...|||| .  |  || ..||.|| ||| ||||..||. ||..|.  ..                  .. |  |..|||| ........|.||
rngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalGdfdlklllsl..................llleplvsaePdvtvleltledddfl

VLACDGIWDIYNNKQLIHFIKYHLVSGTKLDTIITKLLDHGIAqansntGVGFDNMTAIIVVLNR
.||.||.||  .|........ .| .|. |. . ..|.|. .|      . . ||.|...| || 
lLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrlng
subfamily_PPM1G2_pd Subfamily PPM1G2 28-369 3.1e-120 393.4 In-house 6-287 (287) alignment 
Range on Protein: 28-369
Range on HMM: 6-287/287.0
IVPRFYNC-------VGS--MQGYRLTQEDAHLIRNEnsvvyvrffnpFIDKYETLSLNVFAVFDGHGGDDCSKFlsGGRHhrdgngssngngepnagLI
.|......       |||  ||||||..||||...||           ...|... ||..|||||||||....|.  .|..                 ||
vvakesascanaltkvgssamqGyrlnmeDahilene...........lleksddkslalfavfDGhGGakvaky..agkk.................li

KWIAYsfenhhytsttnndsskfKRSFNtlEGLVSQIFKDAFILQDEELYRH--FANSSCGSTAVVACIINEEsLYVANCGDSRCILSSKSNgIKTMSFD
|.||.                  |.||.  || ..||.||||. .||||...  ....|.||||||..|..|. |||||.||||..||||.| .|..|||
kkiak..................kksfk..egaleqilkdafletDeellkdeklkdesaGstavvvlikeek.lyvanaGDsravlsskgn.vkalsfD

HKPQHIGELIRINDNGGTVSLGRVGGVLALSRAFSDFQFKRGVTyphrrtkltnitqnltygTPPQEAQVTVEPDVLMHKIDySKDEFLVLACDGIWDIY
||||...| .||...||.|.|.||.|.||||||..||.||..|.                  ..|.|..||..||||..|.| ..|||||||||||||..
hkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvk..................kkpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvl

NNKQLIHFIKYHLVSGTKLDTIITKLLDHGIAQANSNTGVGFDNMTAIIVVLN
.||.........||||.|||.||..|||...|...||||||.||||..||||.
tnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvll
subfamily_PPM1G_pd Subfamily PPM1G 30-95 3.6e-07 22.5 In-house 17-66 (473) alignment 
Range on Protein: 30-95
Range on HMM: 17-66/473.0
PRFYNCVGSMQGYRLTQEDAHlirneNSVVyvrffnpfiDKYETlsLNVFAVFDGHGGDDCSKFLS
 ..  ....|||.|  |||||     |...         |  |.   ..|||.||||| . .|. .
eelsygasamqGwrvsqEDah.....ncit.........dlded..tslfavyDGHGGkevakyva
PP2Cc_SM00332 32-366 2.3e-62 203.9 In-house 10-274 (274) alignment 
Range on Protein: 32-366
Range on HMM: 10-274/274.0
FYNCVGSMQGYRLTQEDAHLIRNENSvvyvrffnpfidkyETLSLNVFAVFDGHGGDDCSKFLSGGRHHRDGNGSSNGNGEPNAGLIKWIAYSFENHHYT
. . . ||||.| ..|||| .... .              |  .  .|.|||||||....||.|   ..   .  .. ..| .    ......|.. .  
lsygkssmqgwrksmeDahvvvvdlv..............eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdee

STTNNDSSKFKRsfntleglvsqifkdafilqdeelyrhfanSSCGSTAVVACIINEEsLYVANCGDSRCILSSKSNgIKTMSFDHKPQHIGELIRINDN
 .....|.. ..                              ...||||||| . .|  |||||.||||..|..... .. .| ||||..  |. ||...
ileeeqskelen..............................alsGstavvallkked.lyvanvGDSravlcrngk.avqlsvdhkpedederkRikka

GGTVSLGRVGGVLALSRAFSDFQFKRGVtyphrrtkltnitqnltygtPPQEAQVTVEPDVLMHKIdYSKDEFLVLACDGIWDIYNNKQLIHFIKYHLVS
||.|. ||| |.||.|||| |...|.                      ...|  .| |||| ....  |.||||.||.||.||  .|.... ... .| .
ggvvekgrvngglavsrafGdhflkknk....................klkepyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllak

GT-KLDTIITKLLDHGIAQAnsntGVGFDNMTAIIV
|  .  . . .|||   ...    | . ||.|...|
gktndpqeaaelldeeairr....ggseDniTvvvv
subfamily_PPM1A_pd Subfamily PPM1A 34-369 6e-53 173.0 In-house 14-281 (282) alignment 
Range on Protein: 34-369
Range on HMM: 14-281/282.0
NCVGSMQGYRLTQEDAHLIRNEnsvvyvrffnpfIDkyETLSLNVFAVFDGHGGDDCSKFLSGGRHHRDGNgssngngepnaglikwiaysfenhhytst
 .| ||||.| . |||| .  .            .   .. . . |||||||.|....|. .   ..   .                             
ygvssmqgwrvemEDahtvvas............lg..alkdwsfFavfDGHaGsevakyvkkhllenile.............................

tnndSSKF--KRSFNTLEGLVSQIFKDAFILQDEELYRHFANSS----CGSTAVVaCIINEESLYVANCGDSRCILSSKSNgIKTMSFDHKPQHIGELIR
    ....  . . .. .  |.. ....|. .||.. .......    .|||||. ....|..|..||.|||| .|... .  . .. ||||..  |  |
....eeelkeaaleasekdevkealrqgfLaldeairelstdlktadksGsTavt.vlvsekhliianlGDsRavlcrngk.aaflteDHkpsrpkEkkR

INDNGGTVSLGRVGGVLALSRAFSDFQFKRgvtyphrrtkltniTQnltyGTPPQEAQVTVEPDVLMHKIDYSKDeFLVLACDGIWDIYNNKQLIHFIKY
|.. ||.|  .|| | ||.|||. |...|.              ..      ...| .|. ||.| . ... ..| |||||||||||. .......... 
ieqAGGsvvvsRvnGaLAvsRalGDyeyke..............ee....ekkaeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrk

HLVSGTKLDTIITKLLDHGIAQaNSNtgvgfDNMTAIIVVLN
.|  ...| .. ..|.|. . . .|.     ||.....|...
rlevadeleevakalvdkalek.gsr.....DNlsvlvvlfa
0049733 PP2C-like 35-369 8.2e-40 129.6 In-house 6-234 (235) alignment 
Range on Protein: 35-369
Range on HMM: 6-234/235.0
CVGSMQGY-RLTQEDAHLIrnensvvyvrffnpfidkyetlSLNVFAVFDGHGGDDCSKFLSGGRHHRDGNGSSN----Gngepnaglikwiaysfenhh
.. |..|. | ..|||.|.                      .| .|||.|||||  .....|.  ..   .   .    .                    
gaasdigrvrkvneDavlv......................glllfavaDGhgghaagevasellvetllelllelllld....................

ytsttnndsskfkrsfntleglVSQIFKDAFILQDEELYRHFANS----SCGSTAVVACIInEESLYVANCGDSRCILSSkSNGIKTMSFDHKPQHIGEL
                      . .....||   .|.|...  .|     .|.|||||... .. |||||.||||..| . .. .  ...||.| .  | 
......................leealrkaflaaneallelalaspelagmgtTavvalld.ggklyvanvGDsrayllr.dgklvqltedhspvneler

IRINDNGGTVslgRVGGVLALSRAFSDFQFKrgvtyphrrtkltnitqnltygtppqeaqvtvePDVLMHKIDYSKdeFLVLACDGIWDIYNNKQLIHFI
 || . || |   || |.|||.||. |...|                                 ||| .....     ||.||.||.|| ..........
qriitaggav...rvpgrlaltralGdlllk.................................pdvtvlelepgd..flllasDGlwdvlsdeeivdll

KYhlvsgTKLDTIITKLLDHGIAqansntGVGFDNMTAIIVVLN
.      . |. .  .|... .|      . | ||.|...| |.
rs.....ldleeaaerlvelala......rggrDNiTvvvvrld
subfamily_PPM1E_pd Subfamily PPM1E 39-96 6.4e-07 21.8 In-house 11-60 (265) alignment 
Range on Protein: 39-96
Range on HMM: 11-60/265.0
MQGYRLTQEDAHLIRNE-NSVVYVrffnpfidkYETLSLNVFAVFDGHGGDDCSKFLSG
... | ..|| |.. .. |... .          ..    .||||||||| ...|. . 
vknkrrkmEDrhvaledlnelfel.........kdekeraffavfDGHgGveaakyaaa
subfamily_PPM1H_pd Subfamily PPM1H 70-220 2.4e-14 45.9 In-house 56-204 (404) alignment 
Range on Protein: 70-220
Range on HMM: 56-204/404.0
KYETLSLNVFAVFDGHGGDDCSKFLSGGRHHRDGNGSSNgngePNAGLIKWIAYSFE--NHHYTSTTNNDSSKFKRSFNTLEGLVSQIFKDAFILQDEEL
. |.|.|..|..||||.|   .   |   |..  .  ..        | .  | . |  ... .. ... |......  . | ||   . .||.  || .
eeeklplayfglfDGhaGsgaalvaskllhkhlkekled....vlellleksaeeeenteesskespssvseiyeekeiskeeLviGalesaflemDeqi

YRHFA--NSSCGSTAVVACIINeESLYVANCGDSRCILSsKSNGIKTMSFDHKPQ
 |     . . | ||.|| ... . ||||| |||| ||. ... |. .|.|. |.
arereayrikGGCtalvalvll.gklYvanaGDsRailv.rkdeiiplsadftPe
subfamily_PPM1L_pd Subfamily PPM1L 72-256 4.1e-22 71.7 In-house 31-188 (269) alignment 
Range on Protein: 72-256
Range on HMM: 31-188/269.0
ETLSLNVFAVFDGHGGDDCSKFLSGGRHHRDGNGSSNGngepnaglikwiaysfenhhytsttnndsS-------KfkrsfntleGLVSQIFKDAFILQD
.  . ..|||||||||.  ..|      .   |   .                                                   |....|  .  |
nktgesffavfdGhGGefaaefakdvlvkaiknkliel.............................dadkentep.........infsklltdeilsvd

EELYRHF--ANSSCGSTAVVAcIINEESLYVANCGDSRCILSSKSNGIKTMSFDHKPQHIGELIRINDNGGTVSL---GRVGGVLALSRAFSDFQFK
|.|  .   |.   |.||..| ...|. | ||| |||| .|  |.     .|||||||.. |  ||.. || ...    || |||| |||. |. .|
ekllekakraediaGttalia.lvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk
PPM_PTC7_SpoIIE 82-350 8e-39 126.8 In-house 3-225 (230) alignment 
Range on Protein: 82-350
Range on HMM: 3-225/230.0
FDGHGGDDCSKFLSGGRHHRDGNGSSNGNGEPNAGLIKWIAYSFEnhHYTSTTNNDSSKFKRsFNTLEgLVSQIFKDAFIL--QDEELYrhfaNSSCGST
..........|..............|.|..   .  . .     .  ...... ..  .  . |..|| ....|..... .  .|.| .    .||.|.|
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.fagle.kpeeilrrlnlalaadlede....psssgaT

AVVACIINEE-SLYVANCGDSRCILSSKsNGIktmsfdhkpqhigELIRInDNGGTVS----LGRVGGVLALSRAFSDFQFKRgvtyphrrtkltnitqn
||||.| ..   |||||.|||...|... .|              | .|| . || .|     ||| ||||.|.|. |. ..                  
avvalidpstgklyvanaGdsppllvrd.dgg.............ereri.vagglpslGilpgrvfgvlavslapGdlllly.................

ltygtppQEAQVTVEPDvLMHKIDYSKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGtkldtIITKLLDHGIAQA
        .  |. |||  .......|||||.||.||.||  ....|.......|..      .  .||...|...
.......tDGvveaepd.tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aaeglleDDitll
PPM_PTC7 89-354 1.1e-73 240.8 In-house 10-258 (259) alignment 
Range on Protein: 89-354
Range on HMM: 10-258/259.0
DCSKFLSGGRHHRDGNGSSNGNGEPNAGLIKWIAYSFENHHYTSTTNNDSSKFKRSFNTLEgLVSQIFKDAFIL--QDEELYRHFAN---SSCGSTAVVA
 ..|..... .. ....||.|. . .   . . ... |...|........ | ..||..|| .........|    .||||... ||   |..|||||||
gfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeele.klekalrksflaldtdeelksseantepstsGstAvva

CIINEEsLYVANCGDSRCILSSKSNGIKTMSFDHKPQHIGELIRINDNGGTVS---LGRVGGVLALSRAFSDFQFKRGVTyphrrtkltnitqnltygtp
.|.... |||||.||||..|... | .|....||||..  |  ||...||.||    ||| ||||.|||| ||..|...|                    
litgsk.lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket....................

pQEAQVTVEPDVLMHKIDYSkDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGtKLDTIITKLLDHGIAQANSNT
 .| .|. |||. ..|||.. ||||.||.||.||..............| .. ... ...||.|..||......
.eeqlvsaePdisstkidee.defliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargsedn
PP2C Protein phosphatase 2C 90-354 1.8e-72 237.0 Pfam-A 11-254 (255) alignment 
Range on Protein: 90-354
Range on HMM: 11-254/255.0
CSKFLSGGRHHRDGNGSSNGNGEPNAGLIKWIAYSFENHHYTSTTNNDSSKFKRSFNTLEgLVSQIFKDAFIL-QDEELYRHFAN---SSCGSTAVVACI
..|..... .. . ...|.|. . .   . .  .. |...|........ | ..||..|| .|.......|   .||||... ||   |..|||||||.|
arksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele.kvekalrksfladtdeelksskantepsksGstavvali

INEEsLYVANCGDSRCILSSKSNGIKTMSFDHKPQHIGELIRINDNGGTVS-LGRVGGVLALSRAFSDFQFKRGVtyphrrtkltnitqnltygtppqEA
 ... |||||.||||..|..|.| .|....||||..  |  ||...||.||  ||| |.||.|||. ||..|...                       |.
rgkk.lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.......................eq

QVTVEPDVLMHKIDYSkDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTKLDTIITKLLDHGIAQANSNT
.|. |||| ..|.... ||||.||.||.||..............| ...........|.|..||......
lvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedn
PP2C Protein phosphatase 2C 90-354 1.8e-72 237.0 In-house 11-254 (255) alignment 
Range on Protein: 90-354
Range on HMM: 11-254/255.0
CSKFLSGGRHHRDGNGSSNGNGEPNAGLIKWIAYSFENHHYTSTTNNDSSKFKRSFNTLEgLVSQIFKDAFIL-QDEELYRHFAN---SSCGSTAVVACI
..|..... .. . ...|.|. . .   . .  .. |...|........ | ..||..|| .|.......|   .||||... ||   |..|||||||.|
arksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflele.kvekalrksfladtdeelksskantepsksGstavvali

INEEsLYVANCGDSRCILSSKSNGIKTMSFDHKPQHIGELIRINDNGGTVS-LGRVGGVLALSRAFSDFQFKRGVtyphrrtkltnitqnltygtppqEA
 ... |||||.||||..|..|.| .|....||||..  |  ||...||.||  ||| |.||.|||. ||..|...                       |.
rgkk.lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.......................eq

QVTVEPDVLMHKIDYSkDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTKLDTIITKLLDHGIAQANSNT
.|. |||| ..|.... ||||.||.||.||..............| ...........|.|..||......
lvsaePdvtsvkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedn
PP2C_2 Protein phosphatase 2C 102-328 1.1e-06 21.1 Pfam-A 31-194 (212) alignment 
Range on Protein: 102-328
Range on HMM: 31-194/212.0
DGNGSSNgNGEPNAG-LIKWIAYSFENHHYTSTTNNdsskfkrsfntLEGLVSQIFKDAFI---LQDEELYRHFANSSCGSTAVVACiINEESLYVANCG
|| || . ... .|  . .... ..|... .. ...            | |. || ...     |..|.  ..   .. ..| ..|. |... ......|
DGaGsak.rSdkGarlaveaagealeklleeeseqe...........eeallrqieneilasvklkqeaeaqqeelkdyatTlllav.itpgeivffqiG

DSRCILSSKSNGIKTMSFDHKPQHIGELIRINDN--GGTVslgrvggvlalsrafsdfqfkrgvtyphrrtkltnitqnltygtppqeaqvtvepdvLMH
|.......... .. .. ... .. .|. .. ..  ....                                                          . 
Dgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.........................................................rir

KIDYSKDEFLVLACDGIWDIY-NNKQLIHFIKYH
... .. . |.|  ||..| . ..........  
rlklepgdalllmTDGvsdslrkeepfrellael
PP2C_2 Protein phosphatase 2C 102-328 1.1e-06 21.1 In-house 31-194 (212) alignment 
Range on Protein: 102-328
Range on HMM: 31-194/212.0
DGNGSSNgNGEPNAG-LIKWIAYSFENHHYTSTTNNdsskfkrsfntLEGLVSQIFKDAFI---LQDEELYRHFANSSCGSTAVVACiINEESLYVANCG
|| || . ... .|  . .... ..|... .. ...            | |. || ...     |..|.  ..   .. ..| ..|. |... ......|
DGaGsak.rSdkGarlaveaagealeklleeeseqe...........eeallrqieneilasvklkqeaeaqqeelkdyatTlllav.itpgeivffqiG

DSRCILSSKSNGIKTMSFDHKPQHIGELIRINDN--GGTVslgrvggvlalsrafsdfqfkrgvtyphrrtkltnitqnltygtppqeaqvtvepdvLMH
|.......... .. .. ... .. .|. .. ..  ....                                                          . 
Dgaivvrdrdgevqllgepdsgeyanettfltsedaeeel.........................................................rir

KIDYSKDEFLVLACDGIWDIY-NNKQLIHFIKYH
... .. . |.|  ||..| . ..........  
rlklepgdalllmTDGvsdslrkeepfrellael
subfamily_PDP_pd Subfamily PDP 136-339 1.6e-29 96.3 In-house 114-322 (398) alignment 
Range on Protein: 136-339
Range on HMM: 114-322/398.0
NDSSKFKRSFNTLEG-LVSQIFKDAfilqDEELYRH-FANSSCGSTAVVACiINEESLYVANCGDSRCILSSKS-NG---IKTMSFDHKPQHIGELIRIN
. ... |..|..|   ......|..    .|.  |. .. .  |..|..|  |....|.||| ||.|..| ... .|    ...| |.  .   |. ||.
kvkealkkaFlklDkdistealkkl....kekslreallvalsGacallal.iegtelhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRik

DN------GGTVSLGRVGGVLALSRAFSDFQFKRGVTYPHRRTKL--TNITQNLTYGTPPQeaqVTVEPDVLMHKIDySKDEFLVLACDGIWDIYNNKQL
 .         .  ||. | |. .||| |...|      ..  .   .....   | |||    .| ||.|. ||.  ..| ||||| ||.||. .|.. 
keHPgeesktvirngRlLgeLqPlRAFGdvryKwseelqkkvlekaylkvlepkdyktPPY...ltaePevtshklr.endkFLvlatDGLwdllsneev

IHFIKYHLVSGTKLDTII
.. .. || . .. . . 
vslVgehlakkkekepvk
subfamily_ILKAP_pd Subfamily ILKAP 142-260 1.4e-18 60.0 In-house 75-202 (293) alignment 
Range on Protein: 142-260
Range on HMM: 75-202/293.0
KRSFNTLEGLVSQIFKDAFILQDEELYRHFANSS----CGSTAVVACIINeESLYVANCGDSRCILSSKSNGIK-----TMSFDHKPQHIGELIRINDNG
| .... |  . . . |.|  .|||. .  ...      ||||.|  ... . ||||| |||...|  |..  .     ... ||.| .  |  ||.  |
ksdvsakekeikkclvdsfkktdeefLklaskakPvWkdGstatvvlvld.nvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaG

GTVSLGRVGGVLALSRAFSDFQFKRG-VT
|.|  ||| |||  ||.  | .|||  |.
gvvrdgrvlGvlevsrsiGdgrfkrlGvi
subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 146-327 1.1e-16 54.2 In-house 58-272 (292) alignment 
Range on Protein: 146-327
Range on HMM: 58-272/292.0
NTLEGLVSQIFKDAFilQDEELYRHfANSSCGSTAVVACIINEESLYVANCGDSRCILSS----KSNGIKTMSFDHKPQHIGELIRINDNGGTVS-----
.. | |. .| . |   . ..|. . |. |.....| | . .. .|..|| ||||..|        . .. .| ||||.  .|  ||   || |      
elsealllrildiaa..kldkltid.aresattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvr

------LGRV------GGVLALSRAFSDFQF-KRGV-TYPHR-----RTK---------LTNITQNLTYGTPpQEAQVTVEPDVLMHKIDYSKDEFLVLA
        ||       | ||||||  || . . || . |       |            ..|.....|  |   ..| .  |  ..|   |.|.|||||
gwgfrGtarvwrrrqqeGdlalsralGdfhlfeaGvvaePelqihagrqylgrgpglwtrssiarhiayqhp.ltsdvplgldrklekeldsddaflvla

CDGIWDIYNNKQLIHFIKY
 ||. |   |.... ... 
sdGvldvllnaevvlllak
subfamily_PPM1K_pd Subfamily PPM1K 152-267 6.5e-15 47.9 In-house 67-193 (263) alignment 
Range on Protein: 152-267
Range on HMM: 67-193/263.0
VSQIFKDAFILQDEELYRHFANS-------SCGSTAVVACIINEESLYVANCGDSRCILSSKSNGiKTMSFDHKPQHIGELIRINDNGGTV---SLG--R
. ...|.||   |..| |.   |       | |.|| |. . .   | .|. |||| ||  . .  | .. ||.|..  |  ||   ||.|   |||  .
leivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtelvlaslGdsrailcrnGka.kkltrdhdPeleeekerikaagGsvewnslgkpl

VGGVLALSRAFSDFQFKRGVTYPHRRTK
| |.||..|.. |...||        ||
vngrlamtrslGdldlkryGviatPetk
subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 152-368 1.1e-11 37.2 In-house 83-276 (276) alignment 
Range on Protein: 152-368
Range on HMM: 83-276/276.0
VSQIFKDAFILQDEELYRHFANsscGSTAVVACIINEE---------SLYVANCGDSRCILSSKSNGIkTMSFDHKPQHIGELIRINDNGGTVSLG--RV
 |....|.|   |..|  .  .   |.|| .| . ..           | ||| |||  .||   . .  .|.||| .   |  || |.| |.| .  |.
qskllldlfkevdaklkdfeye...GatatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGnesl.elskdhkatdpeekqrikddGitlsdnqtri

GGVlALSRAFSDFQFKRgvtyphrrtklTNITqnlTYGTPPQEAQVTVEPdvlmhkidysKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTKLDTIIT
 |. |.|||. |   |.            ||      ..|    .... |          .|.||..| ||.||. . |. |  .|     ..  | . .
nGl.avsralGdhfike...........lniG...lisepyvsnrilltp..........fdkflivasdGlwdvisGkdaiekvkslydqqatedkmas

KLLDHGIAQANSNtgvgfDNMTAIIVVL
 ||.  |  . .      ||.. |.| |
slletaiqsikak.....dnvsvivvkl
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 153-257 4.2e-20 65.1 In-house 74-179 (255) alignment 
Range on Protein: 153-257
Range on HMM: 74-179/255.0
SQIFKDAFILQDEELyRHFAnSSCGSTAVVACIInEESLYVANCGDSRCILSSKSNGIKTMSFDHKPQHIGELIRINDNGGTVSLG----RVGGVLALSR
 ...|.|.   .  .  . .   .|.||... || |.  |.|| |||| .|. |    | .|.||||..  |  ||.. ||||  .    || | ||.||
vkslkkaykeistqi.serp.kfiGttaasvlii.edkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsr

AFSDFQFKR
|. |  .. 
alGdsfleP
subfamily_KAPP-like_pd Subfamily KAPP-like 153-368 2.2e-12 39.6 In-house 80-266 (266) alignment 
Range on Protein: 153-368
Range on HMM: 80-266/266.0
SQIFKDAFILQDEELYRHFANsscGSTAVVACII---NEESLYVANCGDSRCILSSKSNGIkTMSFDHKPQHIGELIRINDNGGTVSLG--RVGGVlALS
|.....||   |..|  .  .   |.|| .| .    .   | ||| |||  .||   . .  .|.||| ..  |  || |.| |.| .  |. |. |.|
skllenafkevdaklkdfeye...GatatlalvwsdGqqrylqvanvGdssaflsrGnesl.elskdhkakdpeekqrikddGitlsdnqtrinGl.avs

RAFSDFQFKRgvtyphrrtklTNITqnlTYGTPPQEAQVTVEPdvlmhkidysKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTKLDTIITKLLDHGI
||. |   |.            ||      ..|    .... |          .|.||..| ||.||. . |. |  .|     ..  | . . ||.  |
ralGdhfike...........lniG...lisepyvsnrilltp..........fdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletai

AQANSNtgvgfDNMTAIIVVL
  . .      ||.. |.| |
qsikak.....dnvsvivvkl
subfamily_PPM1E_pd Subfamily PPM1E 154-258 3e-18 58.9 In-house 78-185 (265) alignment 
Range on Protein: 154-258
Range on HMM: 78-185/265.0
QIFKDAFILQDEELYRH--FANSSCGSTAVVaCIINEESLYVANCGDSRCILSSKSNGIKTMSfDHKPQHIGELIRINDNGGTVSL---GRVGGVLALSR
. .|.|| | ||.. ..    .  .|||||| ..|... ||||  |||. .| .| . .. |.  |||..  |  ||...||.|      || |||..||
ealkeafkltDerflqkaereklksGstavv.vliekdqlyvaWlGDsqallvrkgeavqlmk.pHkPeredEkkRieeagGlvvvigawRvnGvLsvsR

AFSDFQFKRG
|  | . |. 
aiGDvklkpy
PP2C_SIG_SM00331 172-366 8.3e-15 47.9 In-house 82-215 (217) alignment 
Range on Protein: 172-366
Range on HMM: 82-215/217.0
ANSSCGSTAVVACI-INEESLYVANCGDSRCILSSKSNGIKTMSFdhkpqhigelirindnggtvslgrvggvlalsrafsdfqfkrgvtyphrrtkltn
 ... . |...|.. ...  |..||.||||..|  ... ..  ..                                                       
eekgmfaTlllalydfssgklsyanaGdsrpyllrdgklveilkd.......................................................

itqnltygtpPQEAQVTVEPDVL--MHKIDYSKDEFLVLACDGIWDI-----YNNKQLIHFIKYHLvsGTKLDTIITKLLDHGIAQANSNTGvgFDNMTA
          .. |.. .||.|   .......|...|.|. ||...      .....|..... ..  .. .. . .| ..  ...|. . |  .|..| 
..........vegaplGlepevsvdirelelekgdllllytDGltearsekgfaeerleeiledlv..dseaqelaqkiveellelakgsng..eDdiTv

IIV
..|
vvv
subfamily_PPM1D_pd Subfamily PPM1D 173-369 1.7e-21 69.6 In-house 105-308 (309) alignment 
Range on Protein: 173-369
Range on HMM: 105-308/309.0
NSSCGSTAVVaCIINEESLYVANCGDSRCILSSKSN-----GIKTMSFDHKPQHIGELIRINDNGGTVSLGrvGGVL--ALSRAFSDfqfKRGVTYpHRR
 |  |.|| |  || .| ||||. |||. .|..| .       |..  ||||... |  ||.. || |.     ||   . .|   .   ..| |    .
lstaGttasv.viirreklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaak..sGvkRvvWkRprle...hngptv.ide

TKLTNITQNL----TYGTPPQEAQVTVEPDVLMHKIDYSKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTK----LDTIITKLLDHGIAQANSnTGVG
    ...  |     | .  .|  |  ||||  ...| ....|..|| ||.|.. . .. ..... .   ..       .. ..|..... . .|   . 
iPFLavaRslGDlWsynaksgefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrs.kklr

FDNMTAIIVVLN
 ||...|.|.|.
aDnvsvivvile
subfamily_PPM1G_pd Subfamily PPM1G 174-370 8e-50 163.2 In-house 294-472 (473) alignment 
Range on Protein: 174-370
Range on HMM: 294-472/473.0
SSCGSTAVVaCIINEESLYVANCGDSRCILSSKSNGIKtMSFDHKPQHIGELIRINDNGGTVS-LGRVGGVLALSRAFSDFQFKRGVTYPHRRTKltnit
.. |.|||| ....|..|.||| |||||.||.. . .  .| ||||.   || ||.  ||.|   ||| | | ||||. |. .|.  . |..        
edsGttAvv.aLlkekklivAnaGDsRcvlsrnGkAld.lslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqm.....

qnltygtppqeaqVTVEPDVLMHKIDySKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGT--KLDTIITKLLDHGIAQANSNTGVGFDNMTAIIVVLNR
             ..  ||. ....  ..||||||||||||.. . .. . |.. .|  |.  .| .|...|||. .|.  |. | | ||||.|||.|..
.............isAlPDikvltlt.eedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivllkk
subfamily_TAB1_pd Subfamily TAB1 175-258 2e-13 42.8 In-house 128-215 (333) alignment 
Range on Protein: 175-258
Range on HMM: 128-215/333.0
SCGSTAVVACIINEEsLYVANCGDSRCILSS--KSNGIKTMSFDHKPQHIGELIRINDNG---GTV-SLGRVGGvLALSRAFSDFQFKRG
| |.||||| |.|.. |||||.|||| .|    .|. .| .| ||. .   ||.|..| |    .. . .|.|.     |.  |.. | |
sgGttAvvalifnnk.LyVaNvGdsrAllvkrkesekvkqLsvdHttdNedEllRlkdLGldieqikrnkrlgs.kentRsiGdykvkkg
subfamily_PP2D1_pd Subfamily PP2D1 186-329 9.6e-07 20.8 In-house 185-306 (492) alignment 
Range on Protein: 186-329
Range on HMM: 185-306/492.0
INEESLYVANCGDSRCILSSKsNGIKTMSFDHKPQHIGELIRINDNGGTVSLGRVGGvlaLSRafSDFQFKRGVTYphrrtkltnitqnltYGTPPQEAQ
..   ||.|| |. . .|  .    ...  .| |.   |  |.. .|..|. .   |   |       .  ||. .               || |  .  
eelgvlyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvksekng...lvn..GildttRGLGn...............yGdpkLkks

VTVEPDVLMHKIDySKDEFLVLACDGIWDIYNNKQLIHFIKYHL
| .|| .   |.|  .. |||||  |.|..... . .  .|  |
vipePkttsvkld.eaaqflvlAsnGlWevlseeevlsLvkqtl
subfamily_PPM1E_pd Subfamily PPM1E 278-369 6.9e-14 44.7 In-house 178-263 (265) alignment 
Range on Protein: 278-369
Range on HMM: 178-263/265.0
GTPPQEAQVTVEPDVLMHKIDySKDEFLVLACDGIWDIYNNKQLIHFIKYHLVSGTKLDTIITKLLDHGIAQANSNtgvgfDNMTAIIVVLN
| . ... |. |.||   ..| ...|.|.|||||.||. |...... .. .| .|..  . ..||| .   .|.|.     ||.|...|.|.
GDvklkpyvsgeadvaeveld.gseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagss.....Dnitvvvvfld
subfamily_PPM1L_pd Subfamily PPM1L 285-330 4.4e-10 32.2 In-house 192-237 (269) alignment 
Range on Protein: 285-330
Range on HMM: 192-237/269.0
QVTVEPDVLMHKIDYSKDEFLVLACDGIWDIYNNKQLIHFIKYHLV
 |  .||.|  ..|  | |||.||.||.|| . |.. ..||| .| 
lviadpdiltfdlddhkpeflilasdGlwdtfsneeavrfikerlk
subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 285-326 1e-07 24.5 In-house 180-221 (255) alignment 
Range on Protein: 285-326
Range on HMM: 180-221/255.0
QVTVEPDVLMHKIDYSKDEFLVLACDGIWDIYNNKQLIHFIK
 |. .||.      . ||.||.||||||||.  ... .. . 
fvvpdPdlsqsleiskkdkflilacdGiwdlisdeeaveiva
subfamily_ILKAP_pd Subfamily ILKAP 286-330 4e-07 22.5 In-house 201-244 (293) alignment 
Range on Protein: 286-330
Range on HMM: 201-244/293.0
VTVEPDVLMHKIDYSkDEFLVLACDGIWDIYNNKQLIHFIKYHLV
|.  |||   ...   | |.||||||.|. ..... ..||   | 
vistPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvle
Subfamily Dicty-PPM1L-like 287-368 8.9e-07 21.0 In-house 221-303 (305) alignment 
Range on Protein: 287-368
Range on HMM: 221-303/305.0
TVEPDVLMHKIDYSKDEFLVLACDGIWDIYNNKQLIHFIKYHLVS---GTKLDTIITKlLDHGIAQANSNTGVGfDNMTAIIVVL
  ..|  .. .  . |.||||| ||.|......... ..|  |     . |..      . . |..   . |.| ||.| .|. |
iPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfne.isrviveeavkrgsg.Dnitlviikl
PPM_PTC7_SpoIIE_motif 295-366 4.9e-07 23.3 In-house 5-78 (81) alignment 
Range on Protein: 295-366
Range on HMM: 5-78/81.0
HKIDYSKDEFLVLACDGIW-------DIYNNKQLIHFIKYHlvSGTKLDTIITKLLDHGIAqanSNTGVGFDNMTAIIV
..... ... |.|..||..       .......|..... .  .| .|. .. ||.|. ..    . |   |..| ...
aefqLkpgdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvl
PPM_PTC7_motif 306-354 2.8e-13 43.2 In-house 1-50 (51) alignment 
Range on Protein: 306-354
Range on HMM: 1-50/51.0
VLACDGIWDIYNNKQLIHFIKYHLV-SGTKLDTIITKLLDHGIAQANSNT
.||.||.|| .............|   |...  ...|| |. .|.. ...
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDn