Gene PPH22 in Saccharomyces cerevisiae

Synonym: YDL134C, PPH21

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP014_AA protein Get Run
ScerP014_AA_66-363 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 67-360 1.4e-112 368.7 In-house 6-299 (309) alignment 
Range on Protein: 67-360
Range on HMM: 6-299/309.0
PLKLTNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVS
|| |..  .. ||..||.| |.  |||... .|. .|...| .| |. ... .....||.|||..|||.|... |  |.....|.||.||||..|.|.. 
pllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevll

YLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGsANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDL
.| |.|..||.....||||||.|.....|||.||.||||| |..|..|.|.....|..|....||.| |||||| . ..||.|.|.| .|.|..|..|||
lllalkllypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWSDPD-DRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
|||||. .| |.. .|||.|..|| .. |.| ..|.|.|| |.|..|..|| . ......|.|||||||.|.||..|..|.||.....||...|.
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepv
0045823 Metallo-dependent phosphatases 68-363 3.9e-119 391.3 In-house 20-327 (473) alignment 
Range on Protein: 68-363
Range on HMM: 20-327/473.0
LKLTNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSY
|  .. .. .||..|||| |.. |.|.|. .|...| ..| .| |. ... .....||.|||..|||.|... |  |.....|.||.||||..|.|.. .
llfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlel

LVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLL
| |.|..||.....||||||.|.....|||.||.|.|| .......| ..... |..|....||.. |||||| ....||.| ..| .|.|..|...|||
llalkikypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldll

WSDPDDRGG--------WGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQN------VVTIFSAPNYCYRCGNQAAIMEVDENHnRQ
||||..  |        .| ||||||..||.|. |.| . |.| || |.|. |.||| . .  .      ..|.|||||||.|.|| ||....||.  ..
wsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.is

FLQYDPSVRP
| |.|||  |
fiqfdpsphp
subfamily_PPP3C_pd Subfamily PPP3C 72-357 6.7e-89 291.7 In-house 22-319 (452) alignment 
Range on Protein: 72-357
Range on HMM: 22-319/452.0
NTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAM
.|.. .|.   ||. |   |.|...... ..| ..|. |...  .. |.|..||.||||.|||.||..||   .|.|||.||||||||.|.|.| || |.
etgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyal

KVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDP
|. ||... .||||||.| .|. . | .||  || | .|...... || .|..||.... .|.|||||| |...|....|.| .|.|. ||.||||||||
kiaypstlfllrGnhecrhlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdP

DDRGGWGI--------SPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQ------QNVVTIFSAPNYCYRCGNQAAIMEVDENHNrQFLQY
 .. |           |.||  . ..   . .| ..|||  | |||.   .||   ..        ..|.||||||.    |.||......|   .  |.
ledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm.nirqf
subfamily_PPP5C_pd Subfamily PPP5C 74-363 1.7e-83 273.3 In-house 17-312 (322) alignment 
Range on Protein: 74-363
Range on HMM: 17-312/322.0
NINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVP----VTICGDVHGQFHDLLELFKIGG-PCPDTNYLFMGDYVDRGYYSVETVSYL
 .. ... .|.. | . | .  .... ..| ..|. .  .  |...    .|.|||.||||.|||..|.. | | ..  ||| ||.|||| .|||..  |
tkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltl

VAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPM-IETIDQVRDLNRIQEVPHEGPMCDLL
...|. ||... . |||||| .. ..||| .|.  || ...| ..||..|...|.. ....|.. .||||      |.|..| ..| .. |.|| ...||
lgfkllyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvell

WSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEV-DENHNRQFLQYDPSVRP
||||... | . | || |..|| |....| ..|.|.|| |.|.. .|||  .|. ...|.||||||| . ||..|.... ..... .| ...    |
wsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeavehp
subfamily_PPP7C_pd Subfamily PPP7C 75-253 3.2e-37 121.2 In-house 17-201 (383) alignment 
Range on Protein: 75-253
Range on HMM: 17-201/383.0
INQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINV----PVTICGDVHGQFHDLLE-LFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLV
 ..... ||.. . . |    |. . . | .||.  .|.. ..      ||.|||.||.. |||  |.| | | .. .|.| ||.||||  ||| .  |.
kdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillill

AMKVRYPHRITILRGNHESRQITQVYGFYDECLRKY--GSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIEtIDQVRDLNR
|. . ||. . . |||||   .   |||  |   ||   .... ... |.| ..|...|.|.||. .|||.| . . .. .  ..|
alllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkier
subfamily_PPP2C_pd Subfamily PPP2C 76-363 8.5e-183 599.1 In-house 2-289 (290) alignment 
Range on Protein: 76-363
Range on HMM: 2-289/290.0
NQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRY
..||..||.|..|..|.|..|..||..| ..|. |.||.....|||.||||||||||||||||||| .|||||||.||||||||||||||..|||.||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRG
..|||||||||||||||||||||||||||||.|||||.|||||||.|.|||||..||||||||||.|.|.|..|.|.|.||||||||.||||||||||||
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVRP
||||||||||.|||.||||.||.||.|.|||||||||||||.|||..|||||||||||||||||||||.|.|......|||.||..| 
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
0053225 Metallo-dependent phosphatases 76-360 1.1e-106 349.5 In-house 7-291 (293) alignment 
Range on Protein: 76-360
Range on HMM: 7-291/293.0
NQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRY
  ||..||.| ..  |||... .|. .| ..|  | |. ... .....||.||...|||.|... | .|.....|.||.||||..|.|.. .| |.|..|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRG
|.....||||||.......|||.||.|||||.|..|....|.....|..||...||.. |||||| . ..||.|..|| ...|.||...||||||||.. 
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
||..|.||.|..|| .. ..| ..|.| || |.||.|..|| . .....||.||||||..|.||..|....||. ...| ...|.
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPP4C_pd Subfamily PPP4C 77-357 1.3e-144 473.8 In-house 2-282 (288) alignment 
Range on Protein: 77-357
Range on HMM: 2-282/288.0
QLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYP
.||. ||.| .|| ..|..| .||. | ..|  | ||. .. |||.|||.||||.|||||||.|| .|.|||||.||.||||.|||||   |.|.|||||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

HRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRGG
 |||..|||||||||||||||||||||||||||||.. |..|||....|..|.||||.|||||| |.|.|..| ..| ||||||||.||||||||.|  |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQY
|..||||||. ||.|..||||..||..||.|||||||||| .  ...|.|..||||||||||| |||.|.||. ...|  .
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_PPP6C_pd Subfamily PPP6C 78-355 2.9e-136 446.3 In-house 2-279 (290) alignment 
Range on Protein: 78-355
Range on HMM: 2-279/290.0
LDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPH
||.|||  .||. |.|.|. .||.. .|.|  | ||.|.. |||.|||.||||.||.|||. ||  |||.|.|.||.|||||||.||...|...|..||.
ldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypd

RITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRGGW
|||.|||||||||||||||||||||.|||.||.|| .|..|| ....|..|....|.|||||| ..|.||.| ..| ||.||.|..|||.||||.|   |
ritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvetw

GISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFL
 .||||||. ||. ....|.|.|.|.||.||||||.||. .  ....||..||||||||||| |.|........|.. 
avsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereak
subfamily_PPG1_pd Subfamily PPG1 78-358 3e-123 403.9 In-house 1-294 (300) alignment 
Range on Protein: 78-358
Range on HMM: 1-294/300.0
LDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPH
||. .|.| |.| | |  |  |..   ..|  | ||. |. |||. |||||||.|.||.|||||..|||||||.|||||||.|||||.| |...|.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITILRGNHESRQITQVYGFYDECLRKY-GSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPD----
|||.||||||||||||||||| |||||| | ..||| .|..|||. ..|..|..|.|.|||||| . .|||.. |.|..|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DRGG--WGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYD
      || |  . .|.||||...|.|. |.| ..||.  | |||||..|||    .. . |..|||||||||||.|.|.|. |...| |  |.
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvye
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 78-360 2.2e-97 318.7 In-house 11-294 (298) alignment 
Range on Protein: 78-360
Range on HMM: 11-294/298.0
LDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPH
| . ... . .. ..|.|| .|...| ....  . .  .. |...|||.|||. ||| ||. .|  ||.||||.||||||| ...|..  |.| ||.||.
lsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypn

RITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDD-RGG
.. .||||||  .| .|||||.|| |.| | .... | |.|. .|.|||. ..|.|.|||||......||.|.|.| .. ..|    ||||.||..   |
nffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkg

WGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
|  . ||....||.|  ... .. |. |..||||.| .|| .  ....|||||||.|| .  | ||.|.|||.    |  . |.
waensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 82-358 4.1e-66 215.9 In-house 4-287 (290) alignment 
Range on Protein: 82-358
Range on HMM: 4-287/290.0
IEHLSK---CEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHR
|||| |    . .|..|.  . . . ..|.    .  .. |..| ||.|||. .||. |.  |  |. ..||.|||||||  |.|   .|  .|.||...
iehllkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskk

ITILRGNHESRQITQVYGFYDECLRKYGSaNVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNR--IQEVPHEGPMCDLLWSDPDD--R
. .|||||| |.. ..|||..|  || || ..||.. |.|. ... | |..||.|.|||.|. ||. . .. |..  ..   .|| . ||||.||.    
vhllrgnhevrkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkd

GGWGI-SPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYD
    .   |.    ||..  ... ..  |||| |||..  ||...  ....||.|||| |. .  |  ||..| | .. ..    
dtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 86-361 5.8e-84 274.5 In-house 3-276 (280) alignment 
Range on Protein: 86-361
Range on HMM: 3-276/280.0
SKCepLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGN
 .|  . | |. |. .   ..|. .. .  .. ||..|||.|||. ||| ||.  .  ||.||||.||||||| . .| .  |.| ||||| .. |||||
lac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPD-DRGGWGISPRGA
||  .| . |||.||. |.| | .... | .|.| .|..|||  .|.|.|||||. . ..|....| |  . ..|    ||||.||. .  ||. ..||.
hevisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgv

GFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSV
   ||...  .. .  |. |||| ||.| .|| .  ....||.||||.|.    |.||.. |||.    |    |..
svifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpal
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 86-354 2.2e-78 256.5 In-house 18-289 (297) alignment 
Range on Protein: 86-354
Range on HMM: 18-289/297.0
SKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGN
  .. ..|. | .|  .|.||.. ....  .| |. .|||.|||| ||| ||. ||  | .||||.||||||| .|.||.  |.| ||..|  . .||||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMI---ETIDQVRDLNRIQEVpHEGPMCDLLWSDPD-DRGGWGISP
||   . .|||||.|| ..| |  ..  | |.|...|.| |. .||.|.||||||..    |.| .|...| .|  .|. ..||||.||     |.    
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQF
||||  ||.|   .     .| |..||||.| .|| .   ...||||||| || .  | ||.| .||. .  |
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsf
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 88-359 1.3e-73 240.4 In-house 7-281 (287) alignment 
Range on Protein: 88-359
Range on HMM: 7-281/287.0
CEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHE
 . .|..|.  . . . ..|.  . .  .. |.||.||.|||..||| .|.  |  |...|||.|||||||  |.| . .| ..|..||... .||||||
ldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

SRQITQVYGFYDECLRKYGsANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQ--EVPHEGPMCDLLWSDPDDRgGWGIS---PR
 ..| ..|||..|  ||..  ...| | |.|...|. | |...|.|.|||.|| ....|... |.. .     .|| . ||||.||.     ..     |
vkkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkir

GAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
.    ||.   ... .. |..|| |||... |||..  ....||.|||| |. .  | .|.. |..  . .| .  |
aisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 88-360 4.8e-65 212.8 In-house 3-275 (280) alignment 
Range on Protein: 88-360
Range on HMM: 3-275/280.0
CEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHE
|. ..  ..  . .|   ..  | |.   . |. . ||.| |..|.  || . |  |. . .|.|||||||   .| .  |...|.||  || .||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGSAnVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGF
.  . ..|||| ||  ||| . .|  |   |. .|...|. ....|.|||||| .  .| .|.. |  |    | . ||||||| ..| ||  | ||  .
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

TFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
 ||. . ||  .. .. || ||||.| .||     . ..|.|| |||| .  | ||.. .. | .  | |  | 
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPP1C_pd Subfamily PPP1C 89-355 2.4e-104 341.5 In-house 8-274 (282) alignment 
Range on Protein: 89-355
Range on HMM: 8-274/282.0
EPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHES
  |.| .. .|.|.| ..|. .  .  .. ||.|.||.|||..||| ||...|  |..||||.|||||||  |.||.  |.|.|..||... .|||||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RQITQVYGFYDECLRKYGSAnVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGFT
 .|...||||||| |.|..  .||.||| |...|..||||.||.|.|||||| .. ..|.|...|  |||..| .|||||||||. . ||. . ||  ||
asinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFL
||.|. |.| . |||.|| ||||.| .|| .  ....||.||||||| . .|..|...|||.   .| 
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 90-362 9.8e-88 287.2 In-house 23-296 (299) alignment 
Range on Protein: 90-362
Range on HMM: 23-296/299.0
PLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESR
 . |... .||..| .|.  .  .  .. |. .|||.|||. ||| .|.. |  ||.|.||.|||||||   .|... |...|..||.|. .||||||  
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecp

QITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTF
 | .|||||.|| ..| |. .| .| | |...|.| |. ..|.|.|||||| ..|.||.|||.| |. |      ||||.|||.   .|    ||  . |
ainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvf

GQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVR
|||. ..  .. |. |.|||||.| .|| .  ....||||||| || .  | ||||.||||    |  . |. .
gqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk
subfamily_PPZ_pd Subfamily PPZ 90-359 8.9e-74 241.7 In-house 24-293 (300) alignment 
Range on Protein: 90-359
Range on HMM: 24-293/300.0
PLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESR
 | .... ..|. | ...  . ..  .. .| | ||||||. ||| ||   |  | .||||.|||||||  |.||.  |.. |..||  . .||||||  
clknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca

QITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTF
..|.|||||||| |.    ..|| | | |. .|..|.|  ||||.||||||.....|..| . |  .||  | . ||||||| |    |    ||  . .
nvtrvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycy

GQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
 .   ..|     . |..||| .| .|| .  ....||.|||||||    |  |.| | |     |   ||
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
PPP_3 91-358 5.6e-116 379.3 In-house 2-270 (271) alignment 
Range on Protein: 91-358
Range on HMM: 2-270/271.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQ
|||.....|.|.. ..|. |.|.  |. |||.|||.|||..|||||||.|||.|.|.|||.|||||||..|.|.. .|.|.|..||.....|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGFTFG
|..||||..|.|.|.|...|.|.....|...|..||.|.|....|||||| |...||.. |.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYD
.|..|.|...|.|.||.|||.|..|||   |...|||.|||||||.|..|..||....|.....| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 91-354 1.4e-80 263.8 In-house 8-277 (284) alignment 
Range on Protein: 91-354
Range on HMM: 8-277/284.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPC------PDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRG
|.| .. .||  | ...  |.  . |..||.|.||.|||| ||| |... |         ...|||.||||||| .|.| .. | |.|...|.....|||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRG
||||| . . |||| || ..| | .....|   |  .|..|.|..||.|.|||.|  .  ..|. .|.|  ..|  | ..|| |.||. .  |.  ||||
nhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprg

AGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQF
|| .||..  ..|... .| |. ||||.||.|| .  ....||||||| || .  | ||...|||.    |
agkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasf
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 91-350 9.2e-57 185.5 In-house 6-290 (302) alignment 
Range on Protein: 91-350
Range on HMM: 6-290/302.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKI-----------GGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRI
.|. ..  |... .. |. |...  |  |||| ||.||||.||. ...                    ..|.|||||||. |.| .. . |.|| ||.. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TILRGNHESRQITQVYGFYDECLRKYGSAN---VWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNR-IQEVPHEGPMCDLLWSDPDDRG
 .||||||.. |   ||| .|   ..| ..   .|. | . | ..|..||| .||.|.|||.|| .|.........| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGISP----------RGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENH
.  . .          ||  ..| .   ... .  .|.|| |||| . ||. .  .....||||||.|     |. |...|| | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 91-350 1.4e-56 184.9 In-house 7-291 (302) alignment 
Range on Protein: 91-350
Range on HMM: 7-291/302.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKI-----------GGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRI
.|. ..  |... .. |. |...  |  |||| ||.||||.||. ...                    ..|.|||||||. |.| .. . |.|| ||.. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TILRGNHESRQITQVYGFYDECLRKYGSAN---VWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNR-IQEVPHEGPMCDLLWSDPDDRG
 .||||||.. |   ||| .|   ..| ..   .|. | . | ..|..||| .||.|.|||.|| .|.........| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGISP----------RGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENH
.  . .          ||  ..| .   ... .  .|.|| |||| . ||. .  .....||||||.|     |. |...|| | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 91-141 8.5e-11 34.6 In-house 9-59 (317) alignment 
Range on Protein: 91-141
Range on HMM: 9-59/317.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGG
..| ... ||  | ...  |.  . ...||||.||.||||.||| |... |
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
PPP_1 92-346 1.2e-115 378.3 In-house 2-264 (264) alignment 
Range on Protein: 92-346
Range on HMM: 2-264/264.0
SEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQI
.|. .|.|.|.....|..|||.. .. ..|.|||.||||.|||.|||.|||.|.|||||.|||||||..|||.. .|.|.|..||.....|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|..|....|..||.||..|..||.|.||...||||||.....||.| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEV
||..||.|..|.|...|.|.||.|||....|||.. ....|||||||.||.....|..|....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PP2Ac_SM00156 92-359 1.1e-107 352.0 In-house 2-269 (271) alignment 
Range on Protein: 92-359
Range on HMM: 2-269/271.0
SEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQI
|. .|..|.. . ..|. |.|.  .. |||..||.|||..|||.|.. .|..|...|.|.|||||||..|.|....|.|.|..|| ....|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGFTFGQ
...|||..|. ||| .......|...|...|..||||.||.|.||||||..|..|..| |.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
|. ..| ..|.|.|| |||..|.||| . .....||||||||||....|.||...|..| . .. |...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 92-141 2.6e-06 19.7 In-house 12-61 (339) alignment 
Range on Protein: 92-141
Range on HMM: 12-61/339.0
SEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGG
   ..| ||. | ...  |  .  .. |. . ||.|||| ||| .. . |
caaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 93-357 1.7e-71 233.9 In-house 5-271 (284) alignment 
Range on Protein: 93-357
Range on HMM: 5-271/284.0
EDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQIT
 .||  |   |..... .  .  .| |. ||||.|||| ||| ||   |    .||||.||||||| . .||.  |.| || .| .. .||||||   | 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGFTFGQ
..||||.|| |.|    |.. |  .|  .|.|||| ..|.|.|||.| |.. . |.| ..|  . |    .  |.||||| . . ||    ||  . || 
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQY
|   ..    .. |. ||||.| .|| .  .. .||||||| || .  | ||.| |..|    |.  
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvl
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 94-360 3.3e-77 252.5 In-house 11-277 (281) alignment 
Range on Protein: 94-360
Range on HMM: 11-277/281.0
DDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQ
...  . ...  ..  |...  |. |... ||.|.||.|| .||.. |  |.. ..|.|||||||  |.|..  | ..|.||..|| .||||||  .. .
eeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnk

VYGFYDECLRKYGSaNVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGFTFGQDI
.|||| ||  |||  ..|  |   |. .|..||..... |.|||||| . ..|..|.  .  . .. | . ||||.|||... .|  | ||..||||...
iygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknv

SEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
 ..   . .. || ||||.|..||.    ....|.||.||||    | ||.. |||. . ..... |.
vddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa
subfamily_PPPLV_pd Subfamily PPPLV 98-350 1.8e-55 181.3 In-house 4-279 (290) alignment 
Range on Protein: 98-350
Range on HMM: 4-279/290.0
RLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLL----ELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQ
 ||..|||.|  ||.. ... |. . ||.||...||      |...|     ...||.||||||| .||| ..||.|.|| || .. .|||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFYDECLRKYGSA--NVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRD----LNRIQEVPHEGPM-CDLLWSDPDDR------------
 . .. |.  |.|    .||. |.. ||..|..| .|.|.|| |.|.   | |  ..      |.|...  .  |.  |.|||||..             
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

-GGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRcGNQAAIMEVDENH
 |    . || |  |..|  |.| . |.|| . |||.   .|.   ..  ..|.||. .||    |.||.. ||...
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkkk
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 105-360 2.5e-63 207.1 In-house 34-292 (307) alignment 
Range on Protein: 105-360
Range on HMM: 34-292/307.0
DVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRK
 ..  |  .  |. |. . ||.|||| ||...| . |  |.| |.| |||||||  |.|..  |...|. ||. | .||||||  .. . ||||.||.  
tifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvts

YG--SANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTFGQDISEQFNHTND
      ..| .|   |. .|..||.  ||.|.|||||| .  .|..|.  .    |  | . |.||.|||     |  | ||.||||| .. ..  .   
ipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlg

LSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
. || ||||....||     ....|||||| ||    |  ... |||    | . . |.
veliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpe
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 116-359 5.5e-55 179.8 In-house 5-255 (263) alignment 
Range on Protein: 116-359
Range on HMM: 5-255/263.0
INVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSAN----VW
.. |. |||| |||. ||| .|.  | .  |.|||.||||||| .|.| .  |...|.  |... .|||||| . | . |||. |  ...   .    |.
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

KMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGFTFGQDISEQFNHTNDLSLIAR
. | ..| |.|. |.| ..|.|.|||.|| ....|..| .    |  .  |. |||||.||.     |. |   |     ||.   ... .  |. || |
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidlivr

AHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
|||.|  ||..  .. ..|.|||  |     | ||.. |..  .  |.|  |
ahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
subfamily_YNL217W_pd Subfamily YNL217W 118-192 1.2e-08 27.7 In-house 10-80 (235) alignment 
Range on Protein: 118-192
Range on HMM: 10-80/235.0
VPVTICGDVHGQFHDLLELFK--IGGPCPDTNYLFMGDYVDRGYYSVETVSYLvamkvrYPHRITILRGNHESRQIT
  . . ||||| . .|.||..  |||  ..   ...|| ...|  |||.|||.        .    ..||||   . 
krllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll
Metallophos Calcineurin-like phosphoesterase 119-311 4.9e-41 134.2 Pfam-A 2-198 (200) alignment 
Range on Protein: 119-311
Range on HMM: 2-198/200.0
PVTICGDVHGQFHDL----LELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYL--VAMKVRYPHRITILRGNHESRQITQVYGFYDECL----------
.....||.||...||    |.|.||..... ...||.||.|||| .| ||  .|   . |...|...  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVrdlnriqevphegpmcdllwsdpddrggwgi
                       ....  ... .. . |.. |  ||||.||.. ||.||.  .. |.                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGFTFGQDISEQFNHTNDLSLIARAHQL
    ... || |  | .   ... |. |.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 120-311 1.1e-79 259.7 In-house 1-197 (198) alignment 
Range on Protein: 120-311
Range on HMM: 1-197/198.0
VTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFD
||.|||.|||..|||.||| |.|.|...|||.|||||||..|.|.. .|.|.|..||.....|||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQL
..|..||.|.|....|||||. |...||..  .| .|.|.||...||     |..........  | ||||..||.|..|.. ..|.|.|| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 120-311 2.9e-75 245.6 In-house 1-196 (197) alignment 
Range on Protein: 120-311
Range on HMM: 1-196/197.0
VTICGDVHGQFHDL-LELFKIG-GPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKyGSANVWKMFTDL
||..||.|||..|| |.|.|.|  | ....|.|.|||||||..|.|.. .|.|.|..||.....|||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQL
||. |..||.|.|....|||||. .|..|......| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.|.|| |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 120-311 1.6e-74 243.2 In-house 1-198 (199) alignment 
Range on Protein: 120-311
Range on HMM: 1-198/199.0
VTICGDVHGQFHDL-LELFKIG-GPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDL
||.|||.|||..|| |.||| |  | ....|.|.|||||||..|.|.. .|.|.|..||.....||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQL
||. |..||.|.|....|||||| |..|.......| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| ..|.|.|| |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 146-359 5.6e-72 235.6 In-house 101-314 (317) alignment 
Range on Protein: 146-359
Range on HMM: 101-314/317.0
TNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETI
 .|||.||||||| .|.| |. |.|.|..||.....|||||||| . . |||| |. ..| ||.....|   |  .|..|.|..||.|.|||.|  .  .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQVRDLNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIM
.|.  |.|  ..|  | ..|| |.||| .  |.  |.||||. ||..  ..|... || |. ||||.|..|| .  ....|||||||.|| .  | ||..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

EVDENHNRQFLQYDP
.||.. .  .  . |
svdkklkisinvlrp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 147-350 4.4e-57 186.7 In-house 121-324 (339) alignment 
Range on Protein: 147-350
Range on HMM: 121-324/339.0
NYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETID
 |||.||||||| .|.| |  | |.|. || || .|||||||| .   |||| |   .|  |.... | ..|. ||. |...| |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QVRDLNRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIME
|.  ..|  |.|  | . || |.|||    |.  | ||| | ||      | .  || .. | ||.| .|| .   . .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

VDENH
.|.. 
idkkl
subfamily_PPP7C_pd Subfamily PPP7C 263-360 7.5e-22 70.6 In-house 237-335 (383) alignment 
Range on Protein: 263-360
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
. |.|||||   .| .  . ||.|  || |..... .  .|.|. |.|.  .||| ..|...|.||||| ||     |. | . . .. . ...||  |
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas