Gene PPH22 in Saccharomyces cerevisiae

Synonym: YDL134C, PPH21

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP014_AA protein Get Run
ScerP014_AA_66-363 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 67-360 1.4e-112 368.7 In-house 6-299 (309) alignment
Range on Protein: 67-360
Range on HMM: 6-299/309.0
PLKLTNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVS
|| |..  .. ||..||.| |.  |||... .|. .|...| .| |. ... .....||.|||..|||.|... |  |.....|.||.||||..|.|.. 
pllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevll

YLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGsANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDL
.| |.|..||.....||||||.|.....|||.||.||||| |..|..|.|.....|..|....||.| |||||| . ..||.|.|.| .|.|..|..|||
lllalkllypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWSDPD-DRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
|||||. .| |.. .|||.|..|| .. |.| ..|.|.|| |.|..|..|| . ......|.|||||||.|.||..|..|.||.....||...|.
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepv

0045823 Metallo-dependent phosphatases 68-363 3.9e-119 391.3 In-house 20-327 (473) alignment
Range on Protein: 68-363
Range on HMM: 20-327/473.0
LKLTNTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSY
|  .. .. .||..|||| |.. |.|.|. .|...| ..| .| |. ... .....||.|||..|||.|... |  |.....|.||.||||..|.|.. .
llfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlel

LVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLL
| |.|..||.....||||||.|.....|||.||.|.|| .......| ..... |..|....||.. |||||| ....||.| ..| .|.|..|...|||
llalkikypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldll

WSDPDDRGG--------WGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQN------VVTIFSAPNYCYRCGNQAAIMEVDENHnRQ
||||..  |        .| ||||||..||.|. |.| . |.| || |.|. |.||| . .  .      ..|.|||||||.|.|| ||....||.  ..
wsdPweddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.is

FLQYDPSVRP
| |.|||  |
fiqfdpsphp

subfamily_PPP3C_pd Subfamily PPP3C 72-357 6.7e-89 291.7 In-house 22-319 (452) alignment
Range on Protein: 72-357
Range on HMM: 22-319/452.0
NTNINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAM
.|.. .|.   ||. |   |.|...... ..| ..|. |...  .. |.|..||.||||.|||.||..||   .|.|||.||||||||.|.|.| || |.
etgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyal

KVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDP
|. ||... .||||||.| .|. . | .||  || | .|...... || .|..||.... .|.|||||| |...|....|.| .|.|. ||.||||||||
kiaypstlfllrGnhecrhlteyftfkeeckiky.seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdP

DDRGGWGI--------SPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQ------QNVVTIFSAPNYCYRCGNQAAIMEVDENHNrQFLQY
 .. |           |.||  . ..   . .| ..|||  | |||.   .||   ..        ..|.||||||.    |.||......|   .  |.
ledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm.nirqf





subfamily_PPP5C_pd Subfamily PPP5C 74-363 1.7e-83 273.3 In-house 17-312 (322) alignment
Range on Protein: 74-363
Range on HMM: 17-312/322.0
NINQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVP----VTICGDVHGQFHDLLELFKIGG-PCPDTNYLFMGDYVDRGYYSVETVSYL
 .. ... .|.. | . | .  .... ..| ..|. .  .  |...    .|.|||.||||.|||..|.. | | ..  ||| ||.|||| .|||..  |
tkefvkellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltl

VAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPM-IETIDQVRDLNRIQEVPHEGPMCDLL
...|. ||... . |||||| .. ..||| .|.  || ...| ..||..|...|.. ....|.. .||||      |.|..| ..| .. |.|| ...||
lgfkllyPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvell

WSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEV-DENHNRQFLQYDPSVRP
||||... | . | || |..|| |....| ..|.|.|| |.|.. .|||  .|. ...|.||||||| . ||..|.... ..... .| ...    |
wsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfeavehp

subfamily_PPP7C_pd Subfamily PPP7C 75-253 3.2e-37 121.2 In-house 17-201 (383) alignment
Range on Protein: 75-253
Range on HMM: 17-201/383.0
INQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINV----PVTICGDVHGQFHDLLE-LFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLV
 ..... ||.. . . |    |. . . | .||.  .|.. ..      ||.|||.||.. |||  |.| | | .. .|.| ||.||||  ||| .  |.
kdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillill

AMKVRYPHRITILRGNHESRQITQVYGFYDECLRKY--GSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIEtIDQVRDLNR
|. . ||. . . |||||   .   |||  |   ||   .... ... |.| ..|...|.|.||. .|||.| . . .. .  ..|
alllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkier

subfamily_PPP2C_pd Subfamily PPP2C 76-363 8.5e-183 599.1 In-house 2-289 (290) alignment
Range on Protein: 76-363
Range on HMM: 2-289/290.0
NQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRY
..||..||.|..|..|.|..|..||..| ..|. |.||.....|||.||||||||||||||||||| .|||||||.||||||||||||||..|||.||||
kdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvry

PHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRG
..|||||||||||||||||||||||||||||.|||||.|||||||.|.|||||..||||||||||.|.|.|..|.|.|.||||||||.||||||||||||
keritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddrg

GWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVRP
||||||||||.|||.||||.||.||.|.|||||||||||||.|||..|||||||||||||||||||||.|.|......|||.||..| 
gwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr

0053225 Metallo-dependent phosphatases 76-360 1.1e-106 349.5 In-house 7-291 (293) alignment
Range on Protein: 76-360
Range on HMM: 7-291/293.0
NQLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRY
  ||..||.| ..  |||... .|. .| ..|  | |. ... .....||.||...|||.|... | .|.....|.||.||||..|.|.. .| |.|..|
llldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalklly

PHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRG
|.....||||||.......|||.||.|||||.|..|....|.....|..||...||.. |||||| . ..||.|..|| ...|.||...||||||||.. 
pdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlws

GWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
||..|.||.|..|| .. ..| ..|.| || |.||.|..|| . .....||.||||||..|.||..|....||. ...| ...|.
gwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv

subfamily_PPP4C_pd Subfamily PPP4C 77-357 1.3e-144 473.8 In-house 2-282 (288) alignment
Range on Protein: 77-357
Range on HMM: 2-282/288.0
QLDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYP
.||. ||.| .|| ..|..| .||. | ..|  | ||. .. |||.|||.||||.|||||||.|| .|.|||||.||.||||.|||||   |.|.|||||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

HRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRGG
 |||..|||||||||||||||||||||||||||||.. |..|||....|..|.||||.|||||| |.|.|..| ..| ||||||||.||||||||.|  |
dritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedaeg

WGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQY
|..||||||. ||.|..||||..||..||.|||||||||| .  ...|.|..||||||||||| |||.|.||. ...|  .
wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif

subfamily_PPP6C_pd Subfamily PPP6C 78-355 2.9e-136 446.3 In-house 2-279 (290) alignment
Range on Protein: 78-355
Range on HMM: 2-279/290.0
LDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPH
||.|||  .||. |.|.|. .||.. .|.|  | ||.|.. |||.|||.||||.||.|||. ||  |||.|.|.||.|||||||.||...|...|..||.
ldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypd

RITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRGGW
|||.|||||||||||||||||||||.|||.||.|| .|..|| ....|..|....|.|||||| ..|.||.| ..| ||.||.|..|||.||||.|   |
ritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvetw

GISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFL
 .||||||. ||. ....|.|.|.|.||.||||||.||. .  ....||..||||||||||| |.|........|.. 
avsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereak

subfamily_PPG1_pd Subfamily PPG1 78-358 3e-123 403.9 In-house 1-294 (300) alignment
Range on Protein: 78-358
Range on HMM: 1-294/300.0
LDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPH
||. .|.| |.| | |  |  |..   ..|  | ||. |. |||. |||||||.|.||.|||||..|||||||.|||||||.|||||.| |...|.||| 
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITILRGNHESRQITQVYGFYDECLRKY-GSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPD----
|||.||||||||||||||||| |||||| | ..||| .|..|||. ..|..|..|.|.|||||| . .|||.. |.|..|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DRGG--WGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYD
      || |  . .|.||||...|.|. |.| ..||.  | |||||..|||    .. . |..|||||||||||.|.|.|. |...| |  |.
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvye

subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 78-360 2.2e-97 318.7 In-house 11-294 (298) alignment
Range on Protein: 78-360
Range on HMM: 11-294/298.0
LDQWIEHLSKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPH
| . ... . .. ..|.|| .|...| ....  . .  .. |...|||.|||. ||| ||. .|  ||.||||.||||||| ...|..  |.| ||.||.
lsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypn

RITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDD-RGG
.. .||||||  .| .|||||.|| |.| | .... | |.|. .|.|||. ..|.|.|||||......||.|.|.| .. ..|    ||||.||..   |
nffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkg

WGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
|  . ||....||.|  ... .. |. |..||||.| .|| .  ....|||||||.|| .  | ||.|.|||.    |  . |.
waensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpe

subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 82-358 4.1e-66 215.9 In-house 4-287 (290) alignment
Range on Protein: 82-358
Range on HMM: 4-287/290.0
IEHLSK---CEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHR
|||| |    . .|..|.  . . . ..|.    .  .. |..| ||.|||. .||. |.  |  |. ..||.|||||||  |.|   .|  .|.||...
iehllkygvldafsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskk

ITILRGNHESRQITQVYGFYDECLRKYGSaNVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNR--IQEVPHEGPMCDLLWSDPDD--R
. .|||||| |.. ..|||..|  || || ..||.. |.|. ... | |..||.|.|||.|. ||. . .. |..  ..   .|| . ||||.||.    
vhllrgnhevrkvnrlygfkeelarkrgs.rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkd

GGWGI-SPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYD
    .   |.    ||..  ... ..  |||| |||..  ||...  ....||.|||| |. .  |  ||..| | .. ..    
dtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlk

subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 86-361 5.8e-84 274.5 In-house 3-276 (280) alignment
Range on Protein: 86-361
Range on HMM: 3-276/280.0
SKCepLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGN
 .|  . | |. |. .   ..|. .. .  .. ||..|||.|||. ||| ||.  .  ||.||||.||||||| . .| .  |.| ||||| .. |||||
lac..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgn

HESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPD-DRGGWGISPRGA
||  .| . |||.||. |.| | .... | .|.| .|..|||  .|.|.|||||. . ..|....| |  . ..|    ||||.||. .  ||. ..||.
hevisinrkygfkdevkrry.slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgv

GFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSV
   ||...  .. .  |. |||| ||.| .|| .  ....||.||||.|.    |.||.. |||.    |    |..
svifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpal

subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 86-354 2.2e-78 256.5 In-house 18-289 (297) alignment
Range on Protein: 86-354
Range on HMM: 18-289/297.0
SKCEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGN
  .. ..|. | .|  .|.||.. ....  .| |. .|||.|||| ||| ||. ||  | .||||.||||||| .|.||.  |.| ||..|  . .||||
llskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgn

HESRQITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMI---ETIDQVRDLNRIQEVpHEGPMCDLLWSDPD-DRGGWGISP
||   . .|||||.|| ..| |  ..  | |.|...|.| |. .||.|.||||||..    |.| .|...| .|  .|. ..||||.||     |.    
hecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenq

RGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQF
||||  ||.|   .     .| |..||||.| .|| .   ...||||||| || .  | ||.| .||. .  |
rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsf

subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 88-359 1.3e-73 240.4 In-house 7-281 (287) alignment
Range on Protein: 88-359
Range on HMM: 7-281/287.0
CEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHE
 . .|..|.  . . . ..|.  . .  .. |.||.||.|||..||| .|.  |  |...|||.|||||||  |.| . .| ..|..||... .||||||
ldafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

SRQITQVYGFYDECLRKYGsANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQ--EVPHEGPMCDLLWSDPDDRgGWGIS---PR
 ..| ..|||..|  ||..  ...| | |.|...|. | |...|.|.|||.|| ....|... |.. .     .|| . ||||.||.     ..     |
vkkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkir

GAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
.    ||.   ... .. |..|| |||... |||..  ....||.|||| |. .  | .|.. |..  . .| .  |
aisvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp

subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 88-360 4.8e-65 212.8 In-house 3-275 (280) alignment
Range on Protein: 88-360
Range on HMM: 3-275/280.0
CEPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHE
|. ..  ..  . .|   ..  | |.   . |. . ||.| |..|.  || . |  |. . .|.|||||||   .| .  |...|.||  || .||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGSAnVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGF
.  . ..|||| ||  ||| . .|  |   |. .|...|. ....|.|||||| .  .| .|.. |  |    | . ||||||| ..| ||  | ||  .
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

TFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
 ||. . ||  .. .. || ||||.| .||     . ..|.|| |||| .  | ||.. .. | .  | |  | 
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp

subfamily_PPP1C_pd Subfamily PPP1C 89-355 2.4e-104 341.5 In-house 8-274 (282) alignment
Range on Protein: 89-355
Range on HMM: 8-274/282.0
EPLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHES
  |.| .. .|.|.| ..|. .  .  .. ||.|.||.|||..||| ||...|  |..||||.|||||||  |.||.  |.|.|..||... .|||||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RQITQVYGFYDECLRKYGSAnVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGFT
 .|...||||||| |.|..  .||.||| |...|..||||.||.|.|||||| .. ..|.|...|  |||..| .|||||||||. . ||. . ||  ||
asinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFL
||.|. |.| . |||.|| ||||.| .|| .  ....||.||||||| . .|..|...|||.   .| 
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfq

subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 90-362 9.8e-88 287.2 In-house 23-296 (299) alignment
Range on Protein: 90-362
Range on HMM: 23-296/299.0
PLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESR
 . |... .||..| .|.  .  .  .. |. .|||.|||. ||| .|.. |  ||.|.||.|||||||   .|... |...|..||.|. .||||||  
svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecp

QITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTF
 | .|||||.|| ..| |. .| .| | |...|.| |. ..|.|.|||||| ..|.||.|||.| |. |      ||||.|||.   .|    ||  . |
ainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvf

GQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPSVR
|||. ..  .. |. |.|||||.| .|| .  ....||||||| || .  | ||||.||||    |  . |. .
gqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpk

subfamily_PPZ_pd Subfamily PPZ 90-359 8.9e-74 241.7 In-house 24-293 (300) alignment
Range on Protein: 90-359
Range on HMM: 24-293/300.0
PLSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESR
 | .... ..|. | ...  . ..  .. .| | ||||||. ||| ||   |  | .||||.|||||||  |.||.  |.. |..||  . .||||||  
clknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnheca

QITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTF
..|.|||||||| |.    ..|| | | |. .|..|.|  ||||.||||||.....|..| . |  .||  | . ||||||| |    |    ||  . .
nvtrvygfydeckrrc.nikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycy

GQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
 .   ..|     . |..||| .| .|| .  ....||.|||||||    |  |.| | |     |   ||
nkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp

PPP_3 91-358 5.6e-116 379.3 In-house 2-270 (271) alignment
Range on Protein: 91-358
Range on HMM: 2-270/271.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQ
|||.....|.|.. ..|. |.|.  |. |||.|||.|||..|||||||.|||.|.|.|||.|||||||..|.|.. .|.|.|..||.....|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGFTFG
|..||||..|.|.|.|...|.|.....|...|..||.|.|....|||||| |...||.. |.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYD
.|..|.|...|.|.||.|||.|..|||   |...|||.|||||||.|..|..||....|.....| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle

subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 91-354 1.4e-80 263.8 In-house 8-277 (284) alignment
Range on Protein: 91-354
Range on HMM: 8-277/284.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPC------PDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRG
|.| .. .||  | ...  |.  . |..||.|.||.|||| ||| |... |         ...|||.||||||| .|.| .. | |.|...|.....|||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRG
||||| . . |||| || ..| | .....|   |  .|..|.|..||.|.|||.|  .  ..|. .|.|  ..|  | ..|| |.||. .  |.  ||||
nhesrpvnmqygfyleckkry.sealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprg

AGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQF
|| .||..  ..|... .| |. ||||.||.|| .  ....||||||| || .  | ||...|||.    |
agkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasf

subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 91-350 9.2e-57 185.5 In-house 6-290 (302) alignment
Range on Protein: 91-350
Range on HMM: 6-290/302.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKI-----------GGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRI
.|. ..  |... .. |. |...  |  |||| ||.||||.||. ...                    ..|.|||||||. |.| .. . |.|| ||.. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TILRGNHESRQITQVYGFYDECLRKYGSAN---VWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNR-IQEVPHEGPMCDLLWSDPDDRG
 .||||||.. |   ||| .|   ..| ..   .|. | . | ..|..||| .||.|.|||.|| .|.........| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGISP----------RGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENH
.  . .          ||  ..| .   ... .  .|.|| |||| . ||. .  .....||||||.|     |. |...|| | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng

subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 91-350 1.4e-56 184.9 In-house 7-291 (302) alignment
Range on Protein: 91-350
Range on HMM: 7-291/302.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKI-----------GGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRI
.|. ..  |... .. |. |...  |  |||| ||.||||.||. ...                    ..|.|||||||. |.| .. . |.|| ||.. 
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

TILRGNHESRQITQVYGFYDECLRKYGSAN---VWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNR-IQEVPHEGPMCDLLWSDPDDRG
 .||||||.. |   ||| .|   ..| ..   .|. | . | ..|..||| .||.|.|||.|| .|.........| ..|| ..    |||..|| |  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

GWGISP----------RGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENH
.  . .          ||  ..| .   ... .  .|.|| |||| . ||. .  .....||||||.|     |. |...|| | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtng

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 91-141 8.5e-11 34.6 In-house 9-59 (317) alignment
Range on Protein: 91-141
Range on HMM: 9-59/317.0
LSEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGG
..| ... ||  | ...  |.  . ...||||.||.||||.||| |... |
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG

PPP_1 92-346 1.2e-115 378.3 In-house 2-264 (264) alignment
Range on Protein: 92-346
Range on HMM: 2-264/264.0
SEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQI
.|. .|.|.|.....|..|||.. .. ..|.|||.||||.|||.|||.|||.|.|||||.|||||||..|||.. .|.|.|..||.....|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|..|....|..||.||..|..||.|.||...||||||.....||.| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEV
||..||.|..|.|...|.|.||.|||....|||.. ....|||||||.||.....|..|....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl

PP2Ac_SM00156 92-359 1.1e-107 352.0 In-house 2-269 (271) alignment
Range on Protein: 92-359
Range on HMM: 2-269/271.0
SEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQI
|. .|..|.. . ..|. |.|.  .. |||..||.|||..|||.|.. .|..|...|.|.|||||||..|.|....|.|.|..|| ....|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGFTFGQ
...|||..|. ||| .......|...|...|..||||.||.|.||||||..|..|..| |.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
|. ..| ..|.|.|| |||..|.||| . .....||||||||||....|.||...|..| . .. |...
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 92-141 2.6e-06 19.7 In-house 12-61 (339) alignment
Range on Protein: 92-141
Range on HMM: 12-61/339.0
SEDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGG
   ..| ||. | ...  |  .  .. |. . ||.|||| ||| .. . |
caaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmng

subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 93-357 1.7e-71 233.9 In-house 5-271 (284) alignment
Range on Protein: 93-357
Range on HMM: 5-271/284.0
EDDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQIT
 .||  |   |..... .  .  .| |. ||||.|||| ||| ||   |    .||||.||||||| . .||.  |.| || .| .. .||||||   | 
pedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslin

QVYGFYDECLRKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGFTFGQ
..||||.|| |.|    |.. |  .|  .|.|||| ..|.|.|||.| |.. . |.| ..|  . |    .  |.||||| . . ||    ||  . || 
kiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgs

DISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQY
|   ..    .. |. ||||.| .|| .  .. .||||||| || .  | ||.| |..|    |.  
dalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvl

subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 94-360 3.3e-77 252.5 In-house 11-277 (281) alignment
Range on Protein: 94-360
Range on HMM: 11-277/281.0
DDVARLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQ
...  . ...  ..  |...  |. |... ||.|.||.|| .||.. |  |.. ..|.|||||||  |.|..  | ..|.||..|| .||||||  .. .
eeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnk

VYGFYDECLRKYGSaNVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGFTFGQDI
.|||| ||  |||  ..|  |   |. .|..||..... |.|||||| . ..|..|.  .  . .. | . ||||.|||... .|  | ||..||||...
iygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfGknv

SEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
 ..   . .. || ||||.|..||.    ....|.||.||||    | ||.. |||. . ..... |.
vddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpa

subfamily_PPPLV_pd Subfamily PPPLV 98-350 1.8e-55 181.3 In-house 4-279 (290) alignment
Range on Protein: 98-350
Range on HMM: 4-279/290.0
RLCKMAVDVLQFEENVKPINVPVTICGDVHGQFHDLL----ELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQ
 ||..|||.|  ||.. ... |. . ||.||...||      |...|     ...||.||||||| .||| ..||.|.|| || .. .|||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFYDECLRKYGSA--NVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRD----LNRIQEVPHEGPM-CDLLWSDPDDR------------
 . .. |.  |.|    .||. |.. ||..|..| .|.|.|| |.|.   | |  ..      |.|...  .  |.  |.|||||..             
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

-GGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRcGNQAAIMEVDENH
 |    . || |  |..|  |.| . |.|| . |||.   .|.   ..  ..|.||. .||    |.||.. ||...
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilvdkkk

subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 105-360 2.5e-63 207.1 In-house 34-292 (307) alignment
Range on Protein: 105-360
Range on HMM: 34-292/307.0
DVLQFEENVKPINVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRK
 ..  |  .  |. |. . ||.|||| ||...| . |  |.| |.| |||||||  |.|..  |...|. ||. | .||||||  .. . ||||.||.  
tifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeecvts

YG--SANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTFGQDISEQFNHTND
      ..| .|   |. .|..||.  ||.|.|||||| .  .|..|.  .    |  | . |.||.|||     |  | ||.||||| .. ..  .   
ipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnviddvckrlg

LSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
. || ||||....||     ....|||||| ||    |  ... |||    | . . |.
veliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpe

subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 116-359 5.5e-55 179.8 In-house 5-255 (263) alignment
Range on Protein: 116-359
Range on HMM: 5-255/263.0
INVPVTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSAN----VW
.. |. |||| |||. ||| .|.  | .  |.|||.||||||| .|.| .  |...|.  |... .|||||| . | . |||. |  ...   .    |.
lqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvy

KMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGFTFGQDISEQFNHTNDLSLIAR
. | ..| |.|. |.| ..|.|.|||.|| ....|..| .    |  .  |. |||||.||.     |. |   |     ||.   ... .  |. || |
nhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidlivr

AHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDP
|||.|  ||..  .. ..|.|||  |     | ||.. |..  .  |.|  |
ahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp

subfamily_YNL217W_pd Subfamily YNL217W 118-192 1.2e-08 27.7 In-house 10-80 (235) alignment
Range on Protein: 118-192
Range on HMM: 10-80/235.0
VPVTICGDVHGQFHDLLELFK--IGGPCPDTNYLFMGDYVDRGYYSVETVSYLvamkvrYPHRITILRGNHESRQIT
  . . ||||| . .|.||..  |||  ..   ...|| ...|  |||.|||.        .    ..||||   . 
krllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvll

Metallophos Calcineurin-like phosphoesterase 119-311 4.9e-41 134.2 Pfam-A 2-198 (200) alignment
Range on Protein: 119-311
Range on HMM: 2-198/200.0
PVTICGDVHGQFHDL----LELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYL--VAMKVRYPHRITILRGNHESRQITQVYGFYDECL----------
.....||.||...||    |.|.||..... ...||.||.|||| .| ||  .|   . |...|...  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETIDQVrdlnriqevphegpmcdllwsdpddrggwgi
                       ....  ... .. . |.. |  ||||.||.. ||.||.  .. |.                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGFTFGQDISEQFNHTNDLSLIARAHQL
    ... || |  | .   ... |. |.|. 
....gselfgpdalekllekygvdlvlrGHtH

PPP_2 120-311 1.1e-79 259.7 In-house 1-197 (198) alignment
Range on Protein: 120-311
Range on HMM: 1-197/198.0
VTICGDVHGQFHDLLELFKIGGPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDLFD
||.|||.|||..|||.||| |.|.|...|||.|||||||..|.|.. .|.|.|..||.....|||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQL
..|..||.|.|....|||||. |...||..  .| .|.|.||...||     |..........  | ||||..||.|..|.. ..|.|.|| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev

PPP_4 120-311 2.9e-75 245.6 In-house 1-196 (197) alignment
Range on Protein: 120-311
Range on HMM: 1-196/197.0
VTICGDVHGQFHDL-LELFKIG-GPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKyGSANVWKMFTDL
||..||.|||..|| |.|.|.|  | ....|.|.|||||||..|.|.. .|.|.|..||.....|||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQL
||. |..||.|.|....|||||. .|..|......| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.|.|| |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel

PPP_5_Dcr2 120-311 1.6e-74 243.2 In-house 1-198 (199) alignment
Range on Protein: 120-311
Range on HMM: 1-198/199.0
VTICGDVHGQFHDL-LELFKIG-GPCPDTNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYGSANVWKMFTDL
||.|||.|||..|| |.||| |  | ....|.|.|||||||..|.|.. .|.|.|..||.....||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYFPVTALVDNKIFCLHGGLSPMIETIDQVRDLNRIQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQL
||. |..||.|.|....|||||| |..|.......| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| ..|.|.|| |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel

subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 146-359 5.6e-72 235.6 In-house 101-314 (317) alignment
Range on Protein: 146-359
Range on HMM: 101-314/317.0
TNYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETI
 .|||.||||||| .|.| |. |.|.|..||.....|||||||| . . |||| |. ..| ||.....|   |  .|..|.|..||.|.|||.|  .  .
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelldl

DQVRDLNRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIM
.|.  |.|  ..|  | ..|| |.||| .  |.  |.||||. ||..  ..|... || |. ||||.|..|| .  ....|||||||.|| .  | ||..
kqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavl

EVDENHNRQFLQYDP
.||.. .  .  . |
svdkklkisinvlrp

subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 147-350 4.4e-57 186.7 In-house 121-324 (339) alignment
Range on Protein: 147-350
Range on HMM: 121-324/339.0
NYLFMGDYVDRGYYSVETVSYLVAMKVRYPHRITILRGNHESRQITQVYGFYDECLRKYgSANVWKMFTDLFDYFPVTALVDNKIFCLHGGLSPMIETID
 |||.||||||| .|.| |  | |.|. || || .|||||||| .   |||| |   .|  |.... | ..|. ||. |...| |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

QVRDLNRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIME
|.  ..|  |.|  | . || |.|||    |.  | ||| | ||      | .  || .. | ||.| .|| .   . .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

VDENH
.|.. 
idkkl

subfamily_PPP7C_pd Subfamily PPP7C 263-360 7.5e-22 70.6 In-house 237-335 (383) alignment
Range on Protein: 263-360
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGFTFGQDISEQFNHTNDLSLIARAHQLVMEGYSWSHQQNVVTIFSAPNYCYRCGNQAAIMEVDENHNRQFLQYDPS
. |.|||||   .| .  . ||.|  || |..... .  .|.|. |.|.  .||| ..|...|.||||| ||     |. | . . .. . ...||  |
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas