Gene DET1 in Saccharomyces cerevisiae

Synonym: YDR051C, DET1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily HP1-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP017_AA protein Get Run
ScerP017_AA_22-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0037864 Phosphoglycerate mutase-like 23-318 1.7e-34 111.5 In-house 6-204 (211) alignment 
Range on Protein: 23-318
Range on HMM: 6-204/211.0
RPRLIVLIRHGESESNKNKEVNGYiPNhlISLTKTGQIQARQAGIDLLRVLNVDDHnlvedlakkyikdessrrtlplkdytrlsrekdtnivFYTSPYR
... ..|.||||.| |... . |  ..  . ||..|. |||..|  | .     |.                                     .|.||..
lmtrlyLvRHGetewnaegrlqgw.ld..vpLtelGreqaralgealadlglpfda.....................................vysSpll

RARETLKGILDVIDEYNelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylqYRVKDEPRIREQDFGNFQKInSMQDVMKK
||..|.. ||.... ..                                                      ..|. .||.||.||| .. . .......|
RaiqTaeiilealglpl......................................................lpvevdprlrErdfgalegl.tleeiaek

------RSTYGHFFFRFPHGESAADVYDRVASFQETLFRHFHDrqerrPRDVVVLVTHGIYSRVFLMKWFRWTYEEFESFtNVPNGSVMVMELDEsiNRY
      .  .....||.|.||| |||..||... |.|......     . . |..|.||   |..|. .. ...||. .. |.|||||.|.|||.  ...
ypeelvawlrdpydfrppggEsladvvaRvlpaleellarllk.....dgenvlvVsHggvlrallayllglsleellrl.nlpngsvtvleldd..ggw

VL
||
vl
subfamily_PFKFB_pd Subfamily PFKFB 23-154 5.4e-09 27.7 In-house 5-95 (198) alignment 
Range on Protein: 23-154
Range on HMM: 5-95/198.0
RPRLIVLIRHGESESNKNKEVNGYIPnhlisLTKTGQIQARQAGIDLLRvlnvddhnlvedlakkyikdessrrtlplkdytrlsrEKDTNIVFYTSPYR
.|| |.| |||||| ||.... |.       ||. |. .|....  . .                                     |. ...  .|| ..
kpreiylvRhGeseknkkgriggdse.....LterGveyakklakfike.....................................enlkelrvwtselk

RARETLKGIlDV----IDEYNELNSGVriCEDMRYD
|. .| . . ..    . . .||. |.  |... |.
rtiqTaell.glpkeqwkaLdeldaGk..cdgltye
0051064 Phosphoglycerate mutase-like 24-320 6.3e-36 116.9 In-house 3-229 (241) alignment 
Range on Protein: 24-320
Range on HMM: 3-229/241.0
PRLIVLIRHGESESNKNKEVNGYiPNhlISLTKTGQIQARQAGIDLLRVLNVDDhnlvedlakkyikdessrrtlplkdytrlsrekdtniVFYTSPYRR
.. ..|.|||||| |... . |. ..  . ||..|. |||..|  | . .   |                                     ..|.||..|
mkrlyLvRHGesewnaegrlqgw.tD..vpLtelGreqaralgerladlgikfd.....................................avysSpllR

ARETLKGILDVIDEYNelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylqYRVKDEPRIREQDFGNFQKINSMQ-----D
|..|.. |.. ..  .                                                      ..|. .||.||.||| ..  .  .     .
aiqTaeiiaealglpl......................................................lpvvvdprlrEidfgalegltleeiaekfp

VMKKRSTYGHFFFRF-------------------------PHGESAADVYDRVASFQETLFRHFHdrqerRPRDVVVLVTHGIYSRVFLMKWFRWTYEEF
    .  ......|.                         | ||| |||..||... | |.....      . . |..|.||   |..|. .. ...||.
eelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarll.....ldgknvlvVsHggvirallayllglpleel

ESFTnVPNGSVMVMELDESINRYVLRT
 ..  .||||| |.|||.. .|.||..
lrln.lpngsvtvleldddgkrvvlvl
0036887 Phosphoglycerate mutase-like 24-316 8.7e-34 109.2 In-house 1-192 (202) alignment 
Range on Protein: 24-316
Range on HMM: 1-192/202.0
PRLIVLIRHGESESNKNKEVNGYiPNhlISLTKTGQIQARQAGIDLLRVlnvddhnlvedlakkyikdessrrtlplkdytrlsrekdTNIVFYTSPYRR
.. ..|.||||.| |... . |. ..  . ||..|. |||..|  |. .                                       .  ..|.||..|
mtrlyLvRHGetewnvegrlqgd.ld..vpLtelGreqaralgerlagl.......................................pfdavysSpllR

ARETLKGILDVIDEynelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylqyRVKDEPRIREQDFGNFQKIN-----SMQD
|..|.. |.....                                                           |. .||.||.||| .. ..     .. .
aiqTaeiiaealgl.........................................................pvivdprlrEidfgalegltleeiaekyp

VMKKRSTYGHFFFRFPHGESAADVYDRVASFQETLFRHFhdrqerrPRDVVVLVTHGIYSRVFLMKWFRWTYEEFESFTNVPNGSVMVMELDESINRY
 . ..  .....||.|.|||.|||..||... |.|....       . . |..|.||   |..|. ......|.. .. ..|||||.|.|||..  ..
eelaawlrdpydfrppggEsladvvaRvlaaleellarl.......dggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwvl
0053607 Phosphoglycerate mutase-like 24-314 2.8e-28 91.2 In-house 1-182 (191) alignment 
Range on Protein: 24-314
Range on HMM: 1-182/191.0
PRLIVLIRHGESESNKNKEVNGyipnhLISLTKTGQIQARQAGIDLLRVLNVDDHnlvedlakkyikdessrrtlplkdytrlsrekdtnivFYTSPYRR
.. ..|.||||.| |... . |      ..||..|. |||...  | .     |.                                     .|.||..|
mtrlyLvRHGetewnaegrlqg.....dvpLtelGreqaralaellaelglkfda.....................................vysSpllR

ARETLKGIldvideynelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylQYRVKDEPRIREQDFGNFQKINSMQDVMK--
||.|.. |                                                             .. |. .||.||.||| .. ..  .   |  
arqTaeii.............................................................glpvevdprlrEidfgdwegltleelaekyp

---KRSTYGHFFFRFPHGESAADVYDRVASFQETLFRhfhdrqerrpRDVVVLVTHGIYSRVFLMKWFRWTYEEFESFTnVPNGSVMVMELDESIN
    .  ......|.|.||| |||..|| .. |.|..           . |..|.||   |..|. .. ...||.  .  .|||||.|.|||..  
eelaawlrdpldyrppggEsladvaaRvlpaleella..........ggnvlvVaHggvirallayllglpleellrln.lpngsvtvlelddggw
0043909 Phosphoglycerate mutase-like 25-316 8.7e-38 122.5 In-house 3-228 (249) alignment 
Range on Protein: 25-316
Range on HMM: 3-228/249.0
RLIVLIRHGESESNKNKEVNGYIPnhlISLTKTGQIQARQAGIDLLRVLNVDDhnlvedlakkyikdessrrtlplkdytrlsrekdtniVFYTSPYRRA
. ..|.||||.| |... . | .    . ||..|  |||..|  | .     |                                     ..|.||..||
krlyLvRHGetewnaegrfqgwlD...spLtelGreqaralgealkelgipfd.....................................avysSplkRA

RETLKGILDVIDeynelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcYLQYRVKDEPRIREQDFGNFQKINsMQDVMKKRS
..|.. ||. ..                                                      . .. |. .||.||.||| .. .. ......|  
iqTaeiileelg......................................................ldklpvevdprLrErdfGaleglt.kaeiaekyp

TY-----------------------------------GHFFFRFPHGESAADVYDRVASFQETLFRHFHdrqerRPRDVVVLVTHGIYSRVFLMKWFRWT
 .                                    ....|.|.||| |||..|| .. | |.....      . . |..|.||   |..|. .. ..
eelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarll.....kdggnvliVaHggvlrallayllgls

YEEFESFtNVPNGSVMVMELDESINRY
.|.. .. |.||||. |.|||.. . .
ledilrl.nlpngsitvlelddggkpv
0036777 Phosphoglycerate mutase-like 25-320 3.1e-37 120.8 In-house 3-228 (247) alignment 
Range on Protein: 25-320
Range on HMM: 3-228/247.0
RLIVLIRHGESESNKNKEVNGYiPNhlISLTKTGQIQARQAGIDLLRV-LNVDdhnlvedlakkyikdessrrtlplkdytrlsrekdtniVFYTSPYRR
. ..|.||||.| |... . |  ..  . ||..|  ||...|  | .  |..|                                      ..|.||..|
krlyLvRHGetewnaegrfqgw.lD..vpLtelGreqakalgellkelglpfd......................................avysSpllR

ARETLKGILDVIDeynelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcYLQYRVKDEPRIREQDFGNFQKInSMQDVMKK-
|..|.. ||. ..                                                      .  ..|. .||.||.|.| ..   .......| 
AiqTaeiilealg......................................................lsllpvvvdprLrErdyGalegl.tkaeiaeky

-----RSTYGHFFFRF-------------------------PHGESAADVYDRVASFQETLFRHFHdrqerRPRDVVVLVTHGIYSRVFLMKWFRWTYEE
     .   .....|.                         |.||| |||..|| .. | |.....      . . |..|.||   |..|. .. ...|.
peelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarll.....kdgenvlvVsHggvlrallayllglsled

FESFtNVPNGSVMVMELDESINRYVLRT
. .. |.||||. |.|||.. ...||..
ilrl.nlpngsitvleldddgklwvles
0049178 Phosphoglycerate mutase-like 25-316 6.4e-33 106.8 In-house 4-223 (243) alignment 
Range on Protein: 25-316
Range on HMM: 4-223/243.0
RLIVLIRHGESESNKNKEVNGYIPnhlISLTKTGQIQARQAGIDLLRVLNVDDhnlvedlakkyikdessrrtlplkdytrlsrekdtniVFYTSPYRRA
. ..|.||||.| |. . . | .    . ||..|. |||..|  | .     |                                     ..|.||..||
trlyLvRHGetewnaegrlqgwtD...spLtelGreqAralgellaelglkfd.....................................avysSplkRa

RETLKGILDVIDEynelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcyLQYRVKDEPRIREQDFGNFQKINSMQDVMK---
..|.. ||. ..                                                        ...|. .||.||.||| .. ..  .   |   
iqTaeiilealgl......................................................pllpvvvdprLrErdfGalegltkaeiaakype

--KRSTYGHFFFRF-----------------------PHGESAADVYDRVASFQETLFRHFHdrqerRPRDVVVLVTHGIYSRVFLMKWFRWTYEEFESF
   .   . ...|.                       | ||| |||..|| .. |.|....       . . |..|.||   |..|. .. ...||. ..
elvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaell.....hdgktvlvVaHggvirallalllglpleellrl

TnVPNGSVMVMELDESINRY
  .||||| |.|||..  . 
n.lpngsvtvlelddggwvl
0053031 Phosphoglycerate mutase-like 26-256 4.1e-10 32.6 In-house 6-172 (342) alignment 
Range on Protein: 26-256
Range on HMM: 6-172/342.0
LIVLIRHG----ESESNKNKEVNGYIPNHLISLTKTGQIQARQAGIDLLRVLnvddhnlvedlakkyikdessrrtlplkdYTRLSREKDTN-IVFYTSP
.|||.|||    .|  ...   . ..| ..  || .|. ||.. |  | ...                             .. |..  . . .....|.
vivlvRHGaRtPlskgpldplnewfypcgageLTplGreqayelGrrlrkrY.............................lgllpstynpdevyvrssd

YRRARETLKGILDVIDEYNELNSGVRICEdmrydphgkqkhafwprglnntggvyennednicegkpgkcYLQYRVKDEPRIREQDF-GNFQKINSMQDV
..|....   .|  . . .  .. . . .                                         . .. .  ||. ... . .|..    ....
vdRtlqSAqaflaGlfppegtpilnpllg.........................................wqpipihtepessdalllpnydpcpafdkl

MKKRSTYGHFFFRFPHGESAADVYDRVASFQETLFRH
.|.. ...... ...  ..  . . ..  .  . ...
lkealaseevkellerylellqklskglgltlsdlld
0049059 Phosphoglycerate mutase-like 26-299 1.4e-08 27.2 In-house 46-265 (435) alignment 
Range on Protein: 26-299
Range on HMM: 46-265/435.0
LIVLIRHGESESNK-------------------NKEVNGYIPNHLIS-----LTKTGQIQARQAGIDLLRVLnvddHNLvedlakkyikdessrrtlplk
..||.|||.   ..                    ..  ...... ..     || .|. ||.. |  | . .    ..|                     
vqvlfRHGaRtPtsklikklealwekllslltypngplsflndwnyplgageLTplGreqayelGkrlrkrY....gfL.....................

dytrlsrEKDTNIVFYTSPYRRARETLKGILDVIDEYNelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylQYRVKDEPR
        .........|...|....    |  . . .                                                      .... ...
.......ynpdevyvrssdvdRtlqSaqaflaGlfppe.....................................................ilgsqllnp

IREQDFGNFQKINSMQD--VMKKRSTYGHFFFRFPHGESAADV-YDRVASFQETLFRHFHdrqeRRPRDVVVL------------VTHGIYSRvflmkWF
  .... ...  .|..|   .. .. . ... ... ..   .. ..|.... ..|.....      | ||  |            ..||. ..     ..
lnvyqpvpietvdsdndtlpydscpafdellkellasdeflelflerilkllqellpglg....ltpsdvldlydlckydtlllgyahglplp.....fc

RW-TYEEFESFTNV
.. |.||.| . ..
slfteeelevleyl
0047369 Phosphoglycerate mutase-like 26-252 8e-08 25.0 In-house 47-220 (438) alignment 
Range on Protein: 26-252
Range on HMM: 47-220/438.0
LIVLIRHGES-------------------ESNKNKEVNGYIPNHLIS-----LTKTGQIQARQAGIDLLRVLnvddHNLvedlakkyikdessrrtlplk
..||.|||.                     ..  .. .......|..     || .|. ||.. |  | . .    ..|                     
vqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagqLTplGreqayelGkrlrkrY....glL.....................

dytrlsreKDTNI-VFYTSPYRRARETLKGIL------DVIDEYNELNSGvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylQY
           .. ....|...|....    |      .  .|.....                                                  ..
........npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwq................................................pi

RVKDEPRIREQDFG--NFQKINSMQDVMKKRSTYGHFFFRFphgesAADVYDRVASFQET
 .  .|. ..  ..  ...  . .....|.. ..  |. ..      .|...|.... ..
pihtipesddfllnllpsdscpafdellkeflasdeflell.....lkdilkrlkkllpg
0049226 Phosphoglycerate mutase-like 26-236 3.4e-07 22.9 In-house 6-197 (342) alignment 
Range on Protein: 26-236
Range on HMM: 6-197/342.0
LIVLIRHGE---SESNKNKEVNGYIPN-HLISLTKTGQIQARQAGIDLLRVLnvddhnlvedlakkyikdessrrtlplkdYTRLSREKDTN-IVFYTSP
..||||||.     .... . | . .. .|  || .|. ||.. |  | ..                              .. |..  . . . ...|.
vqvliRHGdRtPlakgpldflnewfwgcglgeLTplGreqayelGrrlrkrY.............................lgllpstynpdevyvrssd

YRRARETLKGILDVIDEYNELNSGVR---------ICEDMRYDPHGKQKHAFWPRGLNNTGGVYENNEDNICEGKPGKcylqyRVKDEPRIREQDFGNFQ
..|. ...  .|  . . .  .. |          | |.  .|..   ..  .|.  .  . .. ..| .    .  .     ..|.  .. . .. ...
vdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfleeild.....llkklskllglnlstls

KINS-MQDVMKKRSTYGHFFFRFPHG
.. . ..| .. .. .|. .  ..  
dvadtlydlllyelahglplppwcsl
0046349 Phosphoglycerate mutase-like 26-297 4e-07 22.7 In-house 10-246 (409) alignment 
Range on Protein: 26-297
Range on HMM: 10-246/409.0
LIVLIRHGE-------SESNKNKEVNGYIPNHLIS-LTKTGQIQARQAGIDLLRVLNvDdHNLVedlakkyikdessrrtlplkdytrlsREK----DTN
..||.|||.       |  ..  ..| ....  .. || .|. ||.. |  | .    | ..|.                          ...     ..
vqvlfRHGaRtPtkklsflpnwpginwtngpcgagqLTplGreqayelGkrlrkrYv.d.lgLl..........................psnslynpde

IVFYTSPYRRARETLKGILDVIDEYNELNSGVRICEDMRyDPHgkqkhafW--------PrglnntggvyennednicegkpgkcylqyrVKDEPRIREQ
| ...|...|....   .|  . . .. ..   .. |.  ||.       .        |                              .   ......
iyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdll.dpp.......fqpipidtvp..............................iseddalddt

DFGNFQKINSMQDVMKKRSTYGHFFFRFPHGESAAD--VYDRVASFQETLFRHFH----DRQERRPRDVVV-LVTHGIYSRVFLMKWFRW----TYEEFE
 . ...  . .....|.  ...  . .|. .|. .|  ..|..... ..| ....    . .  .| ||.  |    .| ... ...  |    |.||..
llppdslcpaldkllkenlkslsevleflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplppwcdlftpeelk

SFT
 . 
vla
0048439 Phosphoglycerate mutase-like 26-320 7.6e-07 21.9 In-house 12-337 (391) alignment 
Range on Protein: 26-320
Range on HMM: 12-337/391.0
LIVLIRHGES------------ESNKNKEVNGYIPNHlisLTKTGQIQARQAGIDLLRVLnvddhnlvedlakkyikdessrrtlplK---------Dyt
..||.|||.               ||.  . .. ...   || .|. |... |  | .                                          
vqvlfRHGaRtPtssypnkldpllnkllpngpcglge...LTplGreqlyelGrrlrkrY...........................vdlgllpskyt..

rlsrEKDTNIVFYTSPYRRARETLKGILDVIDeynelnsgvricEDMRYDPHGKQKHAFWPRGLNNT-GGVYENNEDNICEGK-----------------
     . ... ...|...|....    |  .             ..  ....  .    .. .||..  ... . ||  .                    
....lnpsevyvrssdvdRtlqSAqaflaGlf............pplgltvilvivvesedpllnplpintcplledlllldalsalprfylseilerla

-------------PGKCYLQYRVKDEPRIREQDF---GNFQKINSMQDVMKKRSTYGHFFFRF--------------------------PHGesaadVYD
                . |... . |  .. . .    .. ..... |... .  .|  .  .                           .|     .. 
evlnrvlglnltaedvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsg.....eia

RVAS--FQETLFRHFhDRQERRPRDVVVLVTHG--IYSRVFLMKWFRWTYEEFesFTNVPNGSVMVMELDES--INRYVLRT
..|.  .  ......   .  ... ......|   |..   ..  | .|.  .   ...| .| .|.|| |    ..|  | 
klaggpllneilddl.vangpsdpklylyfaHdttiaallsaLglfndtlplp..adlppyasnlvfElyecpsdgeyyVrv
His_Phos_1 Histidine phosphatase superfamily (branch 1) 27-281 1.3e-37 122.1 Pfam-A 2-158 (158) alignment 
Range on Protein: 27-281
Range on HMM: 2-158/158.0
IVLIRHGESESNKNKEVNGYIPnhlISLTKTGQIQARQAGIDLLRvlnvddhnlvedlakkyikdessrrtlplkdytrlsreKDTNIV-FYTSPYRRAR
..|.|||||| ||.....| ..     ||..|. |||..|  | |                                      .| .|  .||||..||.
lylvRHGesewnkegrlqgwsd...vpLtekGreqarelgkkLkr......................................adlpidavytSplkRai

ETLKGILDVIDeynelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylqYRVKDEPRIREQDFG-----NFQKINSMQD-V
.|....|...|                                                         .....|||.||.|||     ..........  
qTaeilleeld.........................................................ipiikeprLrerdfgeweglpkeevkeefpee

MKKRSTyGHFFFRFPHGESAADVYDRVASFQETLFRhfhdrQERRPRDVvVLVTHGIYSRVF
..|. . ....||.|.|||.||||.|||.|.|.|..     .... ..| ..|.||...|..
yekwkr.dkkefrppegesladvyeRvapfleelie.....akdkgenv.livsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 27-281 1.3e-37 122.1 In-house 2-158 (158) alignment 
Range on Protein: 27-281
Range on HMM: 2-158/158.0
IVLIRHGESESNKNKEVNGYIPnhlISLTKTGQIQARQAGIDLLRvlnvddhnlvedlakkyikdessrrtlplkdytrlsreKDTNIV-FYTSPYRRAR
..|.|||||| ||.....| ..     ||..|. |||..|  | |                                      .| .|  .||||..||.
lylvRHGesewnkegrlqgwsd...vpLtekGreqarelgkkLkr......................................adlpidavytSplkRai

ETLKGILDVIDeynelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylqYRVKDEPRIREQDFG-----NFQKINSMQD-V
.|....|...|                                                         .....|||.||.|||     ..........  
qTaeilleeld.........................................................ipiikeprLrerdfgeweglpkeevkeefpee

MKKRSTyGHFFFRFPHGESAADVYDRVASFQETLFRhfhdrQERRPRDVvVLVTHGIYSRVF
..|. . ....||.|.|||.||||.|||.|.|.|..     .... ..| ..|.||...|..
yekwkr.dkkefrppegesladvyeRvapfleelie.....akdkgenv.livsHggvlral
0048955 Phosphoglycerate mutase-like 27-316 2.7e-34 111.5 In-house 3-222 (240) alignment 
Range on Protein: 27-316
Range on HMM: 3-222/240.0
IVLIRHGESESNKNKEVNGYiPNhlISLTKTGQIQARQAGIDLLRVLNVDDhnlvedlakkyikdessrrtlplkdytrlsrekdtniVFYTSPYRRARE
..|.|||||| |... . |. ..  . ||..|. |||..|  | .     |                                     ..|.||..||..
lyLvRHGesewnaegrlqgw.tD..vpLtelGreqaralgerLadlgikfd.....................................lvysSpllRaiq

TLKGILDVIdeynelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylQ---YRVKDEPRIREQDFGNFQKINS-----MQD
|.. |.. .                                                         .   ..|  .||.||.||| ..  .      . .
Taeiiaeal.........................................................glpllpvvvdprlrErdfgalegltldeiaekfp

VMKKRSTYGHFFFRF-------------------------PHGESAADVYDRVASFQETLFRHFHDrqerrPRDVVVLVTHGIYSRVFLMKWFRWTYEEF
    .  ......|.                         |.||| |||..||... |.|......     | . |..|.||   |..|. ......||.
eelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralk.....pgknvlvVsHggvirallayllglpleei

ESFTnVPNGSVMVMELDESINRY
 ..  .||||| |.|||......
lrln.ipngsvtvlelddglvsl
0039931 Phosphoglycerate mutase-like 27-319 1.1e-32 105.6 In-house 2-183 (219) alignment 
Range on Protein: 27-319
Range on HMM: 2-183/219.0
IVLIRHGESESNKNKEVNGyipNhlISLTKTGQIQARQAGIDLLRV--LNvddhnlvedlakkyikdessrrtlplkdytrlsrekdtnIVFYTSPYRRA
..|.||||.| |... . |   .  . ||..|. |||..|  | .                                             ..|.||..||
lyLvRHGetewnvegrlqg...d..spLterGreqaralgerlkdlglpf.......................................davysSpllRa

RETLKGIldvideynelNsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylqYRVKDEPRIREQDFGNFQKIN-----SMQDV
..|.. |          .                                                   . |. .||.||.||| .. ..      . . 
iqTaeii..........g...................................................lpveidprLrEidfgdlegltleeiaekype

MKKRSTYGHFFFRFPHGESAADVYDRVASFQETLFRhfhdrqerrpRDVVVLVTHGIYSRVFLMKWFRWTYEEFESFtNVPNGSVMVMELDEsiNRYVLR
.  .  ......|.|.||| |||..|| .. |.|..           . |..|.||   |..|. .. ...||. .. |.||||| |.|||.  ...||.
elaawlrdpydyrppggEsladvvaRvlpaleella..........genvlvVsHggvirallayllglsleeilrl.nlpngsvtvleldd..ggwvlv
0035570 Phosphoglycerate mutase-like 27-320 1.5e-32 105.2 In-house 2-186 (219) alignment 
Range on Protein: 27-320
Range on HMM: 2-186/219.0
IVLIRHGESESNKNKEVNGyipnhLISLTKTGQIQARQAGIDLLRVLnvddhnlvedlakkyikdessrrtlplkdytrlsrekDTNIVFYTSPYRRARE
..|.||||.| |... . |      . ||..|. |||..|  | .                                        .  ..|.||..||..
lyLvRHGetewnlegrlqg.....dvpLterGreqaralgealadlg.....................................ipfdavysSpllRaiq

TLKGIldvideyNelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylqYRVKDEPRIREQDFGNFQKINsMQD------VM
|.. |       .                                                      . |. .||.||.||| ..  . ...        
Taeii.......g......................................................lpveidprLrEidfgdleglt.ldeiaekypee

KKRSTYGHFFFRFPHGESAADVYDRVASFQETLfrhfhdrqerRPRDVVVLVTHGIYSRVFLMKWFRWTYEEFESFTnVPNGSVMVMELDESINRYVLRT
 ..  ......|.|.||| |||..|| .. |.|          .. . |..|.||   |..|. .. ...||. ..  .||||| |.|||.. ...||..
laawlrdpydyrppggEsladvvaRvlpaleel..........edgenvlvVsHggvirallayllglpleeilrln.lpngsvtvleldggggkwvlvl
0050036 Phosphoglycerate mutase-like 27-311 5.7e-23 73.5 In-house 3-169 (171) alignment 
Range on Protein: 27-311
Range on HMM: 3-169/171.0
IVLIRHGESESNKNKEVNGYipnHLISLTKTGQIQARQAGIDLlrvlnvddhnlvedlakkyikdessrrtlplkdytrlsrekdTNIVFYTSPYRRARE
..|.||||.| |... . |    . ..||..|. |||..|  |                                          .  ..|.||..|||.
lyLvRHGetewnlegrfqgw...tdvpLtelgraqaralgell..........................................pfdavysSpllRArq

TLKGILdvideynelnsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylqYRVKDEPRIREQDFGNFQKINSMQDVMK--KrS
|.. ||                                                             ..|  .||.||.||| .. ..  .   |  .  
Taelil.............................................................lpvivdprLrErdfGawegltldeiaakype.w

TYGHFFFRFPHGESAADVYDRVASFQETLFrhfhdrqerrprDVVVLVTHGIYSRVFLMKWFRWTYEEFESFtNVPNGSVMVMELDE
 . ......| ||| |||..|| .. | |             . |..|.||   |..|. .. ...||. .. ..|||||.|.|||.
lldlldlappggEsladvlaRvlpaleell............gnvlvvaHggvirallalllglsleeilrl.elpngsvlvleldd
subfamily_PGAM_pd Subfamily PGAM 27-317 8.8e-13 40.1 In-house 3-225 (248) alignment 
Range on Protein: 27-317
Range on HMM: 3-225/248.0
IVLIRHGESESNKNKEVNGYIPNhliSLTKTGQIQARQAGiDLLRVlnvddhnlvedlakkyikdessrrtlplkdytrlsREKDTnIVFYTSPYRRARE
.||.|||||| ||..   |..     .|...|. .|..|| ..|.                                    .. .   . |||  .||..
lvllRhGeselnkenkfcgwvDa...kLsekGkeeAkkag.kalkq...................................anlef.divytSvlkRaqq

TLKGILDVIDEYN-ELNSGVRICEDM-----------RYDPHGKQKHAFWPRGLNNTGGVYENNEDNicegkpgkcylqyrvkdeprireqdfgnFQKIN
||. ||. .|. .   ..  |..| .             . .|..|  .| |  . .    |....                             |..||
TlevileeldqekiPvektwrLnErhyGaltglnkaevakkyGeekvkiwRRsydvkPPpveedkey............................fkein

SMQDVMkkrstyGHFFFRFPHGESAADVYDRVASFQETLFRHFHDRqerrpRDVVVLVTHGIYSRVfLMKWFRWTYEEFESFTNVPNGSVMVMELDESIN
. .              ..|. || ..| .|.  . .   ..   .        |..|.||   |  |.|.     .|     ..|.|  .|.||||...
kdrrye......elkeeelPesEslkevveRllpvlneeilkeike.....gkrvlivahgnsvra.llkvlegisdeaikeldlptgiplvyeldenlk

RYV
. .
pvk
subfamily_TIGAR_pd Subfamily TIGAR 111-288 4.2e-12 38.2 In-house 44-176 (222) alignment 
Range on Protein: 111-288
Range on HMM: 44-176/222.0
DTNIV-FYTSPYRRARETLKGILDVIDEYNELNsgvricedmrydphgkqkhafwprglnntggvyennednicegkpgkcylqyrVKDEPRIREQDFGN
. .|.  ..|.  ||..| . || .. | ....                                                     |. ..|.||...|.
nekinyifsSdllRAkqTaeiilkalkekkrea.....................................................verdkrLrEreyGv

FQ--KINSMQDVMKKRSTYGHFFfrFPHGESAADVYDRVASFQETLFRHFHDRQ-------ERRPRDVVVLVTHGIYSRVFLMKWFRW
 .  ... .....| . .  .|    . ||| . .. |.. . | | .. . ..       . ..   |..|.|| ..| .|  ..  
yeGvaldelrellkaagnvpsfv..pegGesieqlelrlvaaleelcakilhleadkkkdgaegelthvlvvshglalrellnvlhve
subfamily_PFKFB_pd Subfamily PFKFB 197-307 8.4e-08 23.9 In-house 76-181 (198) alignment 
Range on Protein: 197-307
Range on HMM: 76-181/198.0
KDEPRIREQDFGNFQKIN------SMQDVMKKRsTYGHFFFRFPHGESAADVYDRVASFQETLFRHFHDrqerrprdvVVLVTHGIYSRVFLMKWFRWTY
..   ..| | |......      .. . .|.| .  ....|.|.||| .|.  |. .   .| |. ..         |....|    || |      ..
eqwkaLdeldaGkcdgltyeeikekfpeefker.kkdkyryryprgEsyedlvqRlepvileLereqen.........vliiaHqavlrvllaylldksa

EEFESfTNVPNGSVMVM
||...  .||  .|. .
eelpy.lkvplhtvikl