Gene PPZ2 in Saccharomyces cerevisiae

Synonym: YGR123C, PPT1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP021_AA protein Get Run
ScerP021_AA_394-694 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 395-692 8.7e-107 349.7 In-house 6-302 (309) alignment 
Range on Protein: 395-692
Range on HMM: 6-302/309.0
PVDIDEIIQRLLDAGYAAKrTKNVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETI
|....|.|..|||. .    .| ..|. .|......||.|... .| |||||  . ..||.|||. |||||. |.||||  ...||||.|||| .|||..
pllllelilslldlliell.lklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevl

LLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDL
||||..|..||.|.||||||||.......|||.||..|. ....|. |.|....|||||.. |||.|||||||| |...|.||.. ||...|..||..||
llllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLDST
|||||..  ... .| ||......  |...||.|.|.||..|.| .|..||..| |..|.||||||||||...|.|||....|.|..|| |..|.. .
lwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
subfamily_PPZ_pd Subfamily PPZ 396-695 1.2e-215 707.5 In-house 1-300 (300) alignment 
Range on Protein: 396-695
Range on HMM: 1-300/300.0
VDIDEIIQRLLDAGYAAKRTKNVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETIL
||||||||.|||||||||||||||||||||.|||.|||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLL
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||||||||.|||||||||||||||
lllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindll

WSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLDSTALK
|||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||.|||
wsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldpldsaalk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 396-690 3.6e-118 387.1 In-house 1-295 (299) alignment 
Range on Protein: 396-690
Range on HMM: 1-295/299.0
VDIDEIIQRLLDAGYAAKRTKNvCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETIL
.|.||.. .||. |.. ||  . ..|. |....|. |.. |. |..|||. . ....||.||||.||||.| | |||| .|.||||||||||.| ||.| 
ldvdellskllnvgmsekrltk.svkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelit

LLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRC-NIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDL
||||.||||||.||.|||||||  . ||||||.||..|    ..|  | |.|...||. .....|.|.|||||| |...| .|...|| | |.  |  ||
lllcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidl

LWSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLD
||.|| .|  .|  | ||||. . .  ... ..... |||.||| ||.|||||| .. |||.|||| |||.|||  |.| | | |.|.| .| | .
lwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptp
0045823 Metallo-dependent phosphatases 396-694 6.7e-112 367.4 In-house 28-329 (473) alignment 
Range on Protein: 396-694
Range on HMM: 28-329/473.0
VDIDEIIQRLldagyaakrTKNVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETIL
.|.|..|..|         .|.  |. .........|.|..  .| |||||. . ..||.|||..|||||. |.||||  ...||||.|||| .|||...
ldldlliehl.........kkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevle

LLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLL
|||..|||||.|.||||||||..... .|||.||. .. ...... |.. ...|||||.. |||..||||||| |...|.||.. || ..||.||. |||
lllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldll

WSDPtDSSNE--------WEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRS------LVTVFSAPNYCGEFDNWGAVMTVSEGLlC
|||| .. .         .. . ||....... |...||.|.|.||..|.| .|..|||...|..      ..||||||||||...|..||....|.| .
wsdP.weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.i

SFELLDPLDSTAL
|| ..||.. . .
sfiqfdpsphpli
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 397-690 1e-126 415.0 In-house 2-295 (298) alignment 
Range on Protein: 397-690
Range on HMM: 2-295/298.0
DIDEIIQRLLDAGYAAKRTKNvCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILL
..||.. ..| .. ..|.  . ..|.... .....|...| .|..|.|. . .|. ||.||||.|||||| |.|||| |||||||||||||.|.||.|.|
evdellievlsvslsekkltk.vikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivl

LLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRC-NIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLL
||.||.|||.|||||||||||. . ||||||.|||||  .......| |.||.|||.|...|.|.|.|||||. |.|.|..|...||.| ..  | .|||
llaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidll

WSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLD
|.||... ..|..|.||||. . . .....|.|.  |||.||| || |||||| .. |||.||||.|||.|||  |||.|.| | .|||.| | .
wadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 398-688 2.3e-97 318.9 In-house 2-294 (297) alignment 
Range on Protein: 398-688
Range on HMM: 2-294/297.0
IDEIIQRLLDAGYAAKRTKNVcLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLL
.|.||  .| |    |   .| . .  ....   | ..| || ...|.   .|..||.|||. |||||| . |.|| |||||||||||||. |.|||.||
vdsiiidvlsasthekllskv.iteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivll

LCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRC-NIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLN---SMDEIRHVSRPTDVPDfGLIND
|.||.|.| |.|||||||||  | .|||||.||..|   .... .| | || |||. ... ||.|.||||||.|    ..| .|.. |.|.  . .|. |
laykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvad

LLWSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDP
|||.||      . .|.||    . . |. |   .| .||||||| ||.||||||  | |||.|||| |||.|||  |.|.. | | ||||.| |
llwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrp
subfamily_PPP1C_pd Subfamily PPP1C 413-690 2.7e-138 452.9 In-house 3-280 (282) alignment 
Range on Protein: 413-690
Range on HMM: 3-280/282.0
KRTKNVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLR
|..|.| ||..|| ....||||..|.||.||||.  ||||||.||||||||||| ..|.|| .|||||||||||||||||||.|||.||||||||.||||
kkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERG
||||.|...|.|||||||||| .||.||||.|.||.|||||.|. ||.|||||||| |.|...||...||..||. ||. ||||||| .....|..|.||
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrG

VSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLD
||| ..| ...|||.|. .||..|||.|||||||||..| |||||||||||||||| |||..|.| ||.||..| | .
vsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpak
0053225 Metallo-dependent phosphatases 414-688 6.8e-98 320.6 In-house 16-290 (293) alignment 
Range on Protein: 414-688
Range on HMM: 16-290/293.0
RTKNVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRG
  ....|. .|.......|.|... .| |||||  . ..||.||...|||.|. |.||||  ...||||.|||| .|||...|||..|..||.|..||||
llllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrG

NHECANVTRVYGFYDECKRRC-NIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTdSSNEWEDNERG
|||..... .|||.||..|.  . ..|. ..|....|||||.. |||..||||||| |...|.||.. ||...|..||..|||||||.   ..|  . ||
NHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyrg

VSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDP
......  |. .||.|.|.||..|.| || |||... |..||||||||||.|...|.|||....|||...| |..|
lgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
subfamily_PPG1_pd Subfamily PPG1 415-679 7e-76 248.3 In-house 9-286 (300) alignment 
Range on Protein: 415-679
Range on HMM: 9-286/300.0
TKNVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGN
 |   | .. . ....| .||.. .  . |.   | .|||||||. |.| .|   |  | .||||||||||||  |.||| ||.. |..||    |||||
qkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgn

HECANVTRVYGFYDECKRRC--NIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPT----------DS
||  ..|.||||| || |.   | ..|| . . |. | ||||.  .|.||||||||   |.|.|. . |  .||. | . |||||||           | 
hesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdr

S-NEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGL
. ...   .||  ..| |  ..|||..  .. . ||| .. .||. . |  | ||.||||||    |  ... . | .
egqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekd
subfamily_PPP2C_pd Subfamily PPP2C 416-688 7.6e-88 287.4 In-house 13-285 (290) alignment 
Range on Protein: 416-688
Range on HMM: 13-285/290.0
KNVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNH
.   |..||. ..|.||.|..  .  . |..  | ..||||||. ||| ||   |  | .||||||||||||  |.||. || . |..|.|   .|||||
eckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnh

ECANVTRVYGFYDECKRR-CNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSsNEWEDNERGVS
|  ..|.|||||||| |.  | ..|| | | |. |||.|.| ..|||.|||||| ....|.||.. |  .||. | . ||||||| |  . |   .||  
esrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr.ggwgisprgag

FCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDP
. . |   .|| .. |. |. ||| .| .||..  || .||.|||||||    | .|.. . . |  ||   ||
ytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdp
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 417-686 9.8e-91 296.8 In-house 5-274 (281) alignment 
Range on Protein: 417-686
Range on HMM: 5-274/281.0
NVCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHE
.| . . ||... .... .|  . || |. . ...|||.|.|. || |||   | .|   ..|||||||||.||||...||...||.|... .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFC
 |.| ..|||| ||. .. ...|  |   || ||..| .. .. |.|||||| | ..||.|   .| . .| ||..||||.||.....||    ||.|| 
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

YNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELL
. |  ...   ... .|. ||| || |||| .. | |.||||.||||  . | .||..| | |  |.  |
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislval
subfamily_PPP7C_pd Subfamily PPP7C 417-581 4.8e-35 114.0 In-house 31-201 (383) alignment 
Range on Protein: 417-581
Range on HMM: 31-201/383.0
NvCLKNSEIIQICHKARELFLAQPALLEL----SPSVKIVGDVHGQYADLLRLFTKCGFPPMA-NYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLL
.  |.   ...| ..|.. . . | . ..    |  | . ||.||.  ||| .. | |.|    .|.| ||.|||||.|.| .|.||.. . ||....| 
k.llhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevyln

RGNHECANVTRVYGFYDECKRRC---NIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVlNSMDEIRHVSR
|||||   .   |||  | . .    . || ... | |  ||||...  ||. ||||.|    ... . ...|
rGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdk.tdlelldkier
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 418-688 6e-110 359.8 In-house 4-274 (280) alignment 
Range on Protein: 418-688
Range on HMM: 4-274/280.0
VCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHEC
 |.|. .| .. .| .....|| ...|.   |...||.||||.||||||....|||  ||||||||||||.| || |||||.||..||.||..||||||.
acikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhev

ANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCY
... | |||.||.||| . .... | . ...|||.|.|.|.|.|.|||||. | |.|..... || | .|  | .||||.|| .    | .| ||||  .
isinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvif

NKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDP
 .  .... .|.  ||..| | ||.|||||| |. ||||||||.|.|||||  ||. |.|.|  |||.| |
ganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkp
subfamily_PPP4C_pd Subfamily PPP4C 418-686 1.1e-90 296.8 In-house 14-282 (288) alignment 
Range on Protein: 418-686
Range on HMM: 14-282/288.0
VCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHEC
  .|..|. ..|.||||... .  . ..   | . ||.|||. |||.||   |  |  |||||||.||||. |.||.||||..|..||..  |.|||||.
elikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhes

ANVTRVYGFYDECKRR-CNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSnEWEDNERGVSFC
 ..|.|||||||| |.  ....|.  .. |. |.||||. |||||||||||| ....|||| . | ..||. | . ||||||| | .  |    ||  . 
rqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagyl

YNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELL
. . ....| .. ...|.|||| .| .|| .  .....||.||||||    |  |.. . | |   |...
fgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkif
subfamily_PPP3C_pd Subfamily PPP3C 418-677 1.7e-80 264.1 In-house 39-311 (452) alignment 
Range on Protein: 418-677
Range on HMM: 39-311/452.0
VCLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHEC
  |.......| ..| .|.  ...|||..  . ..||.|||. |||.||   | |  ..|||||||||||  |.|..| |.. ||.||...|||||||||
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhec

ANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWE-------DNE
  .|  . | .||| . . .........|..|||||.. .. .|||||||| ..|.|.|... |  ..| .|.. |||||||..  .| .       .. 
rhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsv

RGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFND------RSLVTVFSAPNYCGEFDNWGAVMTVSE
|| |. |.  |. .||.|  .  . ||| . ..||. ...       ||.|.||||||.. ..| .||. . .
rGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_PPP6C_pd Subfamily PPP6C 419-678 3.2e-80 262.3 In-house 14-273 (290) alignment 
Range on Protein: 419-678
Range on HMM: 14-273/290.0
CLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECA
 | .... ..|..  .|.| . ..  .|  | ..||.|||. ||. || . |  | ..|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

NVTRVYGFYDECKRR-CNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPtDSSNEWEDNERGVSFCY
..|.||||||||...  | . || ... |. |..|||. ....|||||||| .. .|.|| ..| ...|  | . ||.|||| .  ..|.  .||  . .
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylf

NKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEG
 .   ..|..   ..|.|||| .||.|.... | .||||.||||||    |  ....... 
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaleda
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 419-676 4.4e-73 239.1 In-house 6-288 (302) alignment 
Range on Protein: 419-676
Range on HMM: 6-288/302.0
CLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFT----------KCGFP-PMANYLFLGDYVDRGKQSLETILLLLCYKIKYPEN
 ...||.......  ||.  . .| |.|| | ||||.|||. ||.|...          |  .      ..|||||||||..|.| | |....|. ||.|
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FFLLRGNHECANVTRVYGFYDECKRR----CNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRP-TDVPDFGLINDLLWSDPTDS
. |||||||.  .   ||| .| . |       .||. | ..|  .||||.|  ||.|||||.|| |.|...|....|| ..| .  | .|||..||.| 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

S--------NEWEDN-ERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVS
          ... |  ||.|...|. |.... ......|. |||...  |. || |. |.|.||||.|  | || |||. | 
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
subfamily_PPP5C_pd Subfamily PPP5C 419-678 8e-72 234.9 In-house 33-298 (322) alignment 
Range on Protein: 419-678
Range on HMM: 33-298/322.0
CLKNSEIIQICHKARELFLAQPALLELS----PSVKIVGDVHGQYADLLRLFTKCGFPPMAN-YLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRG
 |..  ...|  .|.||. ..|.|.|..      . . ||.|||. ||| .| . | | . | ||| ||.||||  |.|.||.||..|. ||..||| ||
klhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrG

NHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVL-NSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWeDNERG
|||  |. ..||| .|.| . . |. . | ..|| |||| ..  |.. |||||      ..|..|...| .. |. ||. .|||||| ...  .   .||
nhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqeanGrs.pskrG

VSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTV-SEG
|.. .     .|||.. ...|. |.| | |.|||. .| .|.||||||||| . .| ||..|. .. 
vgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 419-472 8.2e-15 47.8 In-house 8-61 (317) alignment 
Range on Protein: 419-472
Range on HMM: 8-61/317.0
CLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFP
 .|..|.|..|..|||||  .|  |||   |.||||.|||. ||| |.   |.|
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 419-472 2.6e-10 32.9 In-house 10-63 (339) alignment 
Range on Protein: 419-472
Range on HMM: 10-63/339.0
CLKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFP
 .  .|. ..||.||||  ..| .|.|   . ..||.|||. ||| ..   |.|
lfcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
PPP_3 420-686 1.4e-103 338.6 In-house 2-269 (271) alignment 
Range on Protein: 420-686
Range on HMM: 2-269/271.0
LKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECAN
|...|. ....|..|..  .. |.|.|  |...||.|||. |||.||...|..|  .||||||||||||.|||..||||..|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

VTRVYGFYDECK-RRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCYN
...||||..|.. .. . |..|.. ..|..|||||.. .|...||||||| ..|.|.|.. .|...||. |.. |||.|..... . .| ..||..... 
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

KVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELL
. . ..||.|  ..|..||| ..|.|||...|...||||||||||....| ||.....| | ..|..|
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkql
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 420-688 5.3e-99 324.2 In-house 8-282 (284) alignment 
Range on Protein: 420-688
Range on HMM: 8-282/284.0
LKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFP------PMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRG
||. |.|..|..|||||  ..  ||.   ||||||.|||. ||| |.   |.|         .|||||||||||  |.| |.||..||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGV
|||   | . |||| |||.|   .....|  .||..||.|.|. ||.|.|||.|  | ..... ...||.|.|| |.| || |.||  . . ... .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDP
   . . |...||.|| .||| ||| || |||||| || |||.|||| |||..|| .||..|.| |..|| .| |
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 420-690 2.3e-93 305.2 In-house 10-283 (287) alignment 
Range on Protein: 420-690
Range on HMM: 10-283/287.0
LKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECAN
.....|... .|..|..   |||||.   ..||||.|||. ||||.| ..| .|  .||||||||||| .||| .|||...||.||..  |||||||. .
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

VTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDF--GLINDLLWSDPTDSSNEWEDN-ERGVSFC
. ..|||..| ||. . ...|.| | |. ||| |.|. .|.|.|||.|| |.|.|... ...||   .   ||. ||||.||.  ..  | |  |..|  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

YNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLD
. |  ....|.|.. ||. ||| |.|.||.|. |. |||||||| |.||  | |||..||. |  ||  | | |
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkped
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 420-688 1.7e-84 276.3 In-house 16-288 (290) alignment 
Range on Protein: 420-688
Range on HMM: 16-288/290.0
LKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECAN
.....|..| .|..|..   |||||.   . ||||.|||  .||| | . |.||  ..|||||||||| .|||  |||.||||.|...  |||||||. .
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

VTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTD--VPDFGLINDLLWSDPTD-SSNEWEDN-ERGVSF
| |.|||..|  |. . ..|| . | |. |.| | |. ||.|.|||.|. ..| . .. . .|      | ||. ||||.|||   ..  . |  |..| 
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisv

CYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDP
 . | .....|.|....|. ||| | |.|..|  |. |||||||| |.|.  | ||..|||| |  |.  | |
vfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 420-688 9.2e-78 254.5 In-house 6-274 (280) alignment 
Range on Protein: 420-688
Range on HMM: 6-274/280.0
LKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECAN
.   ||| | .    .|. .  | |    .|..||.| || |. |||   |  |  . .||||||||| | .| ..||.| ||.| .  .|||||||  .
mtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetps

VTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCYNK
| ..|||| ||. .  . .|  |   || .|...... ...|.|||||| |  .| || . || .  | ||. ||||||||.  . |  . ||.|. . |
vnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgk

VAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDP
  ...  . .  ||. ||| ||.||||..  | |.|||| |||| .| |  ||. .   |  ||. | |
gvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlip
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 420-676 2.9e-73 239.7 In-house 6-287 (302) alignment 
Range on Protein: 420-676
Range on HMM: 6-287/302.0
LKNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFT----------KCGFP-PMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENF
...||.......  ||.  . .| |.|| | ||||.|||. ||.|...          |  .      ..|||||||||..|.| | |....|. ||.|.
ysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptny

FLLRGNHECANVTRVYGFYDECKRR----CNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRP-TDVPDFGLINDLLWSDPTDSS
 |||||||.  .   ||| .| . |       .||. | ..|  .||||.|  ||.|||||.|| |.|...|....|| ..| .  | .|||..||.|  
illrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq

--------NEWEDN-ERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVS
         ... |  ||.|...|. |.... ......|. |||...  |. || |. |.|.||||.|  | || |||. | 
llaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvd
PP2Ac_SM00156 421-688 4e-108 353.5 In-house 2-269 (271) alignment 
Range on Protein: 421-688
Range on HMM: 2-269/271.0
KNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANV
...|.........|.. ....|.|.|..| .|||.|||. |||||. . |.||  .|.|||||||||.||.|.||||...||.|||...|||||||. .|
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCYNKV
...|||..|.||. . .|.. | ..|. |||||.|  ||.|.|||||| |.|.|.||.. |. . |. ||. |||||||... .... . ||.|. ... 
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

AINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDP
|...||.|. ..|..|||.||..||||| |..|||.|||||||.||.| .||..|...| .|.|.|..
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
PPP_1 421-674 9.9e-108 352.4 In-house 2-263 (264) alignment 
Range on Protein: 421-674
Range on HMM: 2-263/264.0
KNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANV
...|......|..||.  .. |||.|  ....||.|||. |||.||...|..|  |||||||||||||.|.|..||||..|.|||...||||||||...|
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TRVYGFYDECK-RRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLL-------WSDPTDSSNEWEDNERG
|.||||..|.. .... .|.||..|.|..|||||.. .||..||||||| |...|.||...| |.||. | ..|||       .||...... .....||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMT
......| ...|||.|....|..|||.|.|.||||...|..||.|||.||. |..|.||...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 421-679 8.7e-75 244.7 In-house 21-282 (307) alignment 
Range on Protein: 421-679
Range on HMM: 21-282/307.0
KNSEIIQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANV
 . |. .. ..|. .| .. ||... | . .|||.|||. ||. .|   | || . |.| |||||||  |||.||||..||| ||||  ||||||| | |
tkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarv

TRVYGFYDECK---RRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCY
 . ||||.||     .|  .||  |   || ||..|... ||.|.|||||| |  .||.|   .|   |  |..||.||.||  |  ||    ||  | .
nkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftf

NKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGL
    |.   ...| .|. ||| .. |||  .  | |.|.|||| ||  . | |.|. | | |
gtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetl
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 426-698 1.2e-98 323.0 In-house 9-283 (284) alignment 
Range on Protein: 426-698
Range on HMM: 9-283/284.0
IQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYG
  .  .| ..|  || |.|    ..|.||.|||..|||||| | |||  ||||||||||||||. |||||||..||. .|. ||.|||||||. . ..||
etllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiyg

FYDECKRRCNI-KIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDF-GLINDLLWSDPTDSSNEWEDNERGVSFCYNKVAIN
||.||.|| |   ....|   | ..||.|.|  .|.|.|||.| .|. . ..| . || | |.   |  |.||||||.  . |. | ||||. .   |. 
fyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsdalr

KFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLDSTALKQVM
|.|...  ||| ||| ||.|||||| .| |||.|||| |||.|||  ||| | . |.||| .| |    | ...|
klldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiarrrmm
subfamily_PPPLV_pd Subfamily PPPLV 426-676 3.3e-48 157.5 In-house 3-276 (290) alignment 
Range on Protein: 426-676
Range on HMM: 3-276/290.0
IQICHKARELFLAQPALLELSPSVKIVGDVHGQYADLLR---LFTKCGFP-PMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVT
. .|..| . ..|.  ||||   . ..||.||.| ||      . . |     |..||||||||||. |.| |  ||  |. ||  ..|||||||   |.
lslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvq

RVYGFYDECKRRCN---IKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMD------EI-RHVSrpTDVPDFGLINDLLWSDPTDSS--------
  . .. |.. .      ..|..| ..|..|||||..  |.||||.|.     .        .|  ..    |.    |  |.||||| .          
esieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlk..ddidgaplaldilwsdpaedrdlslrgel

---NEWED-NERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFdNWGAVMTVS
   . . | . || .  . . |...||.. . . | ||| | | |... ..  |.||||. .|||   |  |.. |.
vlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss.neaalilvd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 441-690 4.2e-66 216.3 In-house 1-257 (263) alignment 
Range on Protein: 441-690
Range on HMM: 1-257/263.0
ALLELSPSVKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNI----
|||||   ..|.|| |||| ||||.|  ||    ..||||||||||| .||| |.||.  |.  | ...|||||||   . . |||. | |.| .     
allelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevy

-KIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVP-DFGLINDLLWSDPTDSSNEWEDNE-RGVSFCYNKVAINKFLNKFGFDL
  ... | . |. .||.|||. .|.|.|||.|| |.|.|.|| .  | .    . |  ||||.||   .. .| |. | .|  . |  .. . ...  ||
esvynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidl

VCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGLLCSFELLDPLD
. ||| ||| || || || |.|||||  |  |. |. ||. | . |  ||  | | |
ivrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
PPP_2 449-640 5.7e-74 241.1 In-house 1-197 (198) alignment 
Range on Protein: 449-640
Range on HMM: 1-197/198.0
VKIVGDVHGQYADLLRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECK-RRCNIKIWKTFVDTFN
|...||.|||. |||.||......|  .||||||||||||.|||..||||..|..||....|||||||...|..||||..|.. .. . |..|.. ..|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

TLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVPDFGLINDLL----WSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMV
.|||||.. .|...||||||. ....|.|.. .|....|. |...|||    .|||..... .. ..||....... .....|.|. ..|..||| |
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 449-640 4.5e-70 228.7 In-house 1-196 (197) alignment 
Range on Protein: 449-640
Range on HMM: 1-196/197.0
VKIVGDVHGQYADLLRLFTKCG-FPP-MANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDTF
| .|||.|||. |||  ..|.| .|.   .|.||||||||||.|||..||||..|..||....|||||||.......|||..|.... . .|.|.. |.|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVP-DFGLINDL-LWSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMV
..|||||.. .|...||||||. |.|.|.|....|....| . ....|| |||||... . .....||..... . ...|||.| ...|..|.| .
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 449-640 2.7e-67 219.6 In-house 1-198 (199) alignment 
Range on Protein: 449-640
Range on HMM: 1-198/199.0
VKIVGDVHGQYADL-LRLFTKCGFPP-MANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRR-CNIKIWKTFVDT
| ..||.|||. || |.|| ..|.|.   .|.||||||||||.|||..||||..|..||....|||||||. .....|||..|....  . ||.|.. |.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIRHVSRPTDVP-DFGLINDL-LWSDPTDSSNE-WEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMV
|. |||||.. .|...||||||| ..|....... |....| . |  .|| |||||.|. .. .. .|||....... ...|||.| ...|..|.| .
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
Metallophos Calcineurin-like phosphoesterase 449-640 8.8e-40 130.1 Pfam-A 3-198 (200) alignment 
Range on Protein: 449-640
Range on HMM: 3-198/200.0
VKIVGDVHGQYADL----LRLFTKCGFPPMANYLFLGDYVDRGKQSLETILLL--LCYKIKYPENFFLLRGNHECANVTRVYGFYDECK-----------
. ..||.||...||    |.|. ... ..  ..|||||.||||. |.||. ||  |..|...| ..||||||||. ... .|||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDEIrhvsrptdvpdfglindllwsdptdssnewed
                        . . ...  . ..|. |||.|.| |||...||.||. ..| | |                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

nergVSFCYNKVAINKFLNKFGFDLVCRAHMV
     |. ... | .|.|.| | |||.|.|  
....gselfgpdalekllekygvdlvlrGHtH
subfamily_YNL217W_pd Subfamily YNL217W 450-568 1e-08 28.0 In-house 13-138 (235) alignment 
Range on Protein: 450-568
Range on HMM: 13-138/235.0
KIVGDVHGQYADLLRLFT--KCGFPPMANYLFLGDYVDRGKQSLETILLLlcykikYPENFFLLRGNHECANVT------RVYGFYDE--CKRRCNI--K
 .|||||| | .|..|.   . |  . .  ...|| ...| .|.|.. ..        ..   ..|||| . .       .  |. .    ..   .  |
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsflesk

IWKTFVDTFNTLPLA-AIVTGKIFCVHGGLSP
. |  ..    |. .  | . ... ||.||.|
lskadmeyarelgfsldipsdellvvhaGlvp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 475-688 7.9e-86 281.1 In-house 101-314 (317) alignment 
Range on Protein: 475-688
Range on HMM: 101-314/317.0
ANYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMD
 .|||||||||||  |.| ..||...|..||.. ||||||||  .| . |||| |.|.| . .....|  .||.|||.|.|. ||.|.|||.|  | ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

EIRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMT
.. .. ||.|.|| |.. || |.||  . . ... .|| .. . . |...||.|. .||| ||| |||||||||.|| |||.||||.|||..|| .||..
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VSEGLLCSFELLDP
| . | .|...| |
vdkklkisinvlrp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 476-688 2.8e-64 210.4 In-house 121-333 (339) alignment 
Range on Protein: 476-688
Range on HMM: 121-333/339.0
NYLFLGDYVDRGKQSLETILLLLCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNIKIWKTFVDTFNTLPLAAIVTGKIFCVHGGLSPVLNSMDE
 |||||||||||  |.| ..|| . |. ||.  .|||||||   |   |||| | . | . .... | . || .|..|..   |.|.|||.|  | |...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRHVSRPTDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTV
.  . || ..|| |.. || |.||  . . ..   || || .   |.  ||.|. ...| | | |||||||||. | |||.||||||||. ||  ||...
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

SEGLLCSFELLDP
 . |  | ... |
dkklkisinvfrp
subfamily_PPP7C_pd Subfamily PPP7C 583-679 9.6e-17 53.7 In-house 229-325 (383) alignment 
Range on Protein: 583-679
Range on HMM: 229-325/383.0
TDVPDFGLINDLLWSDPTDSSNEWEDNERGVSFCYNKVAINKFLNKFGFDLVCRAHMVVEDGYEFFNDRSLVTVFSAPNYCGEFDNWGAVMTVSEGL
.|  ..  . |.|||||   .  . .  ||    .     .|.|.|....|. |.|    .||||  |. ..|.||| ||  |  | || . ... |
vdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdl