Gene PHO8 in Saccharomyces cerevisiae

Synonym: YDR481C, PHO8

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP022_AA protein Get Run
ScerP022_AA_38-535 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0037220 Alkaline phosphatase-like 39-535 1.8e-133 435.9 In-house 6-476 (479) alignment 
Range on Protein: 39-535
Range on HMM: 6-476/479.0
VVCIGLLLVLVQLAFPSSFALRSASHKKKNVIFFVTDGMGPASLSMARSFN-QHVNDLPIDDILTLDEH-FIGSSRTRSSDSLVTDSAAGATAFACALKS
.... |||.|.. ..   ..|   ..|.||||.|. ||||......|| .  |....| ....|.||.. ..|...|.|.|||||||||.|||.|.  |.
llllllllllalallllalllllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlatGvKt

YNGAIGVDPH----------HRPCGTVLEAAKLAGYLTGLVVTTRITDATPASFSSHVDYRWQEDLIATHQLG----------EYPLGRVVDLLMGGGRS
.|||||||..          ..|..|.||.|| ||. ||||.|||||.||||.| .||  | .|| || ..||          ...||. .|...||||.
nngaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleagckdiatqlvlgsgldvilGGGrk

HFYPQGEKASPYGH----HGARKDGRDLIDEA--QSNGWQYVGDRKNFDSLLKSHGENvtlPFLGLFADNDIPFEIDRDEKEYPSLKEQVKVALGALEKa
.|.|.|..   | .    .| |.|||||..||  ...|..|| .|...|.|  ..  .   ..||||||...|.|.||| .|.|||.| ...|| .|.| 
yflpkgtldpeydlelllggkrldgrdlleeakekkkgytyvtnreeldaldlgsnvd...kllGlfadshlpyeldrdaseePsLaemtekAldlLsk.

snedkDSNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDEAFQYVLEFAEnsDTETVLVSTSDHETGGLVTSRQVTaSYPQYVWYPQVLANATHSGEFLK
     ...||||||||.|||||||.||.| ...||||||||....||||.  | .|..| |.||..|||....... ..| . ..|..|...... ..| 
.....ndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefak..dddTlvvvtADHshgglilgyadr.gnpilgllpgllldglpyttlly

RKLVDFVHEHKGASSKienfikheilekdlgiydytdsdletlihlddnanAIQDKLNDMVSFRAQIGWTTHGHSAVDVNIYAYANKKATWsyvlnnlQG
  ...|.. ..   .                                     ... |. ....||..|||..||...||..||| ...  .       .|
angpgflllldlrldl...................................tllvtlallllqralvgwtsggHtgedVpvyayGpgaelf.......lg

NHENTEVGQFLENFLELNLNEVTDL
..|||...... ..|.|.|.||. |
vyentdiahviasalglgllevlll
subfamily_AP_pd Subfamily AP 44-531 9.7e-143 466.9 In-house 5-470 (472) alignment 
Range on Protein: 44-531
Range on HMM: 5-470/472.0
LLLVLVQLAFPSSFALRSASHKKKNVIFFVTDGMGPASLSMARSFNQH-VNDLPIDDILTLDEH-FIGSSRTRSSDSLVTDSAAGATAFACALKSYNGAI
..| ..| .. ....|.|.|.|.||||.|..||||......||.....  ..|. .. |.|.|. ..|.|.|.|||. |.||||.|||..|..|..||.|
fwlkkaqeelkealelqsnskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktnngti

GVDPH----------HRPCGTVLEAAKLAGYLTGLVVTTRITDATPASFSSHVDYR-WQEDLIA------------THQLGEYPLGRVVDLLMGGGRSHF
||| .          .......||||| ||. ||||.|||.|.|.||....||..| |..|  .            ..|| |.. |. .|...||||..|
GvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeaekegckdiaqQLieeevgkeldvilGGGrkkf

YPQGEKASPYGHHGARKDGRDLID--EAQSNGWQYVGDRKNFDSLLKSHGENvtlpFLGLFADNDIPFEIDRDEKEYPSLKEQVKVALGALEKASnedkd
.|...|.| | ..|.|||||.||.  |.......|| .||..... ||. ..    .||||||.....||||||||.|||||....|| .|.|..     
lpktvkdseyekkgerkDgrnLieewekekknakyvenrkelenvdksktdr....llGlfadshlkyeidrdekeePsLkemtekAlevLskne.....

sNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDEAFQYVLEFAENsdTETVLVSTSDHetgglvTSRQVTASYPQYVWYPQVLANATHSGEFLKRKLvdf
 |||||.|||.||||| |.|.......|.|.||||....||....  ..|..|.|.||      ......|.||.. .....||....| . |....   
.nGffLfVEggrIDhahhenkakkaleetlefdeavelaleltde..edTlivvtaDH......shtltiagypkrgssilglakesksadelpytt...

vhehkgasskienfikheILEKDLGIYDYTDSDLETlIHLDDNANAIQdKLNDMVSFRAqIGWTTHGHSAVDVNIYAYAnkkaTWSYvlnNLQGNHENTE
                  .. ... .|..|.||||.  . .|...| . . .|.|| .| .......|.. ||..||..    ..|.   .|.|..|...
..................lsyangpgyeltesdlee.gerkdlteaet.eakdyvsqaa.vpleeetHggeDvavyasG....pqsh...lltGvveqst

VGQFLENFLELNLNE
..........|. .|
iahvmayaaclgeae
Alk_phosphatase Alkaline phosphatase 66-527 5e-161 526.8 Pfam-A 1-421 (421) alignment 
Range on Protein: 66-527
Range on HMM: 1-421/421.0
KKNVIFFVTDGMGPASLSMARSFNQHVNDLPIDDILTLDE-HFIGSSRTRSSDSLVTDSAAGATAFACALKSYNGAIGVDPHHRPCGTVLEAAKLAGYLT
.||||....||||......|||....... ....||.||. ...|.|.|...|. ||||||.|||.||..|.||||||||.|.... .|||||| ||. |
aknvilligDGmgvstvtaaRslkeqakgklgeeilaldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvdthgkevksvleaAkkaGkst

GLVVTTRITDATPASFSSHVDYRWQEDLIAT-------------HQLGEYPlgRVVDLLMGGGRSHFYPQGEKASpYGHHGARKDGRDLIDEAQSNGWQY
|||.|||.|.||||....||..|..|| .||             .|| ...  ...|.|.||||..|.|.|.|.. ....|.|.|||.||.||...|.||
GlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikak..kkidvllGGGrkeflptgtkde.ekerGtrldgrnlieeakkagyqy

VGDRKnfdSLLKSHGENVTLPFLGLFADNDIPFEIDRDEKEYPSLKEQVKVALGALEKASnedkdsNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDEA
| |||   .|||.. ||.. |.||||||.|...|..|||||.|||||...||. .|.|..      .||||.|||||||||.|.||......||..||||
vsdrk...eLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLskne......kGFFLlVEGsrIDhaaHendavgalsEvvefdeA

FQYVLEFAEnSDTETVLVSTSDHETGglvtsrQVTASYPQYVWYPQVLANATHSGEFLKRKLVDFVHehkGASSKIENfikheilekdlgiydytdsdle
....||||. ...||..|.|.||...      .....|.|.......||.|... .. ..||.....   |...|.|.                      
vkaalefak.keketlvvvTaDHshv......fsiggytqrgtsieglaaakktkdgkakklilygn...gegakved......................

tliHLDDNANAiQDKLNDMVSFRAQIGWTTHGHSAVDVNIYAYANKKAtwsyvlnNLQGNHENTEVGQFLENFLEL
   ....|..| ...|......|...|.|...|...||...||..|..       ...|..|.||....|...|||
...garenvta.eealekiyrkrsavgltseeHtgedvavfAygpkae.......lvrGvqeqteiakvlaaalel
Alk_phosphatase Alkaline phosphatase 66-527 5e-161 526.8 In-house 1-421 (421) alignment 
Range on Protein: 66-527
Range on HMM: 1-421/421.0
KKNVIFFVTDGMGPASLSMARSFNQHVNDLPIDDILTLDE-HFIGSSRTRSSDSLVTDSAAGATAFACALKSYNGAIGVDPHHRPCGTVLEAAKLAGYLT
.||||....||||......|||....... ....||.||. ...|.|.|...|. ||||||.|||.||..|.||||||||.|.... .|||||| ||. |
aknvilligDGmgvstvtaaRslkeqakgklgeeilaldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvdthgkevksvleaAkkaGkst

GLVVTTRITDATPASFSSHVDYRWQEDLIAT-------------HQLGEYPlgRVVDLLMGGGRSHFYPQGEKASpYGHHGARKDGRDLIDEAQSNGWQY
|||.|||.|.||||....||..|..|| .||             .|| ...  ...|.|.||||..|.|.|.|.. ....|.|.|||.||.||...|.||
GlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikak..kkidvllGGGrkeflptgtkde.ekerGtrldgrnlieeakkagyqy

VGDRKnfdSLLKSHGENVTLPFLGLFADNDIPFEIDRDEKEYPSLKEQVKVALGALEKASnedkdsNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDEA
| |||   .|||.. ||.. |.||||||.|...|..|||||.|||||...||. .|.|..      .||||.|||||||||.|.||......||..||||
vsdrk...eLlkakeensvkplLGLFadgdlkvelerdekeePsLkemtevAiklLskne......kGFFLlVEGsrIDhaaHendavgalsEvvefdeA

FQYVLEFAEnSDTETVLVSTSDHETGglvtsrQVTASYPQYVWYPQVLANATHSGEFLKRKLVDFVHehkGASSKIENfikheilekdlgiydytdsdle
....||||. ...||..|.|.||...      .....|.|.......||.|... .. ..||.....   |...|.|.                      
vkaalefak.keketlvvvTaDHshv......fsiggytqrgtsieglaaakktkdgkakklilygn...gegakved......................

tliHLDDNANAiQDKLNDMVSFRAQIGWTTHGHSAVDVNIYAYANKKAtwsyvlnNLQGNHENTEVGQFLENFLEL
   ....|..| ...|......|...|.|...|...||...||..|..       ...|..|.||....|...|||
...garenvta.eealekiyrkrsavgltseeHtgedvavfAygpkae.......lvrGvqeqteiakvlaaalel
Metalloenzyme Metalloenzyme superfamily 321-376 1.6e-07 21.2 Pfam-A 143-196 (252) alignment 
Range on Protein: 321-376
Range on HMM: 143-196/252.0
FLMVEGSRIDHAGHQNDPASQVREVLAFDEAFQYVLEFAENSDTetVLVSTSDHET
|..|    .| .||..|.. .|. . |.||. ...|. .|..|.  .|. |.|| .
fvvvnlantDmvGHtgdveakvkaieavDerlkelldavekedd..lliitADHgn