Gene PTC2 in Saccharomyces cerevisiae

Synonym: YER089C, PTC2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM1A
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP024_AA protein Get Run
ScerP024_AA_2-292 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0034914 PP2C-like 3-292 3e-78 255.4 In-house 2-290 (295) alignment
Range on Protein: 3-292
Range on HMM: 2-290/295.0
QILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTKSDkdHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQ-------KSFHEGNLPRA
..||.|.... ..|    |. .| . .||.|.|.||...  .|.|.  .  .....|.|||||| ..||.. . .||.| |.        .. . .. .|
lllslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslle..dlllfgvfDGhgGhaaaevasellvelllellekllllltlsledieea

LIDTFINTDVKLLQDPVM--KEDHSGCTATSILVskSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIG
|...|...| .||.  ..  . ..||.||. .|.   .| |...|.|||| || ..| .. |..||||.  .|. ||..|.|.| ..||||.||..||.|
lrkaflaadeellelallrpelagsGtTavvali..rgnklyvanvGDSravllrngelvqltvdhkpvnelererilsaggavshgrvngvlavtRalG

DFEFKSNPKLGPEEQIVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCApttegtGIGCDNMSIVVVAL
||..| ...| ..|..|...||.  ..|... |.|..||.||.||.|.....||.|.  |..|..|.|.. ...| . |      . ..||...||| |
dfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAla......rgsrDNiTvvvvrl

subfamily_PPM1G2_pd Subfamily PPM1G2 4-293 1.1e-133 437.6 In-house 1-287 (287) alignment
Range on Protein: 4-293
Range on HMM: 1-287/287.0
ILSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINT
.||.||..|||.|.|..||..| .||||.|..|||.||||...|.|||....|....||||||||||.|.|.|........|||.||.| ..|.|.|..|
tlsepvvakesascanaltkvgssamqGyrlnmeDahilenelleksddkslalfavfDGhGGakvakyagkklikkiakkksfkegaleqilkdaflet

DVKLLQDPVMKEDHSGCTATSILVSKSQnlLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKL
| .||.|  .|....|.||...|.....  |...||||||.||...||.||||.||||. .|||.||.||.||||..|||||||||||.||||||.| |.
DeellkdeklkdesaGstavvvlikeek..lyvanaGDsravlsskgnvkalsfDhkPqeesekkriiaagGfvelnrvngnLalsralgDfefkknvkk

GPEEQIVTCVPDILEHSLDyDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEGTGIGCDNMSIVVVALL
.|||||||.|||.| ..|| ..|||..||||||||.||....||||.  |..|..|.||.....| |.||... ||.|||||..|.|.||
kpeeqivtavPDvlvkkld.eddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieelldkclapdssntgvGcDnmtvvivvll

subfamily_PPM1G_pd Subfamily PPM1G 5-115 1.4e-30 99.8 In-house 2-107 (473) alignment
Range on Protein: 5-115
Range on HMM: 2-107/473.0
LSNPVIDKESHSGADSLTAFGLCAMQGWRMSMEDSHilepNVLTKSDKDhIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTD
||.| ..|||. .. . ...|  |||||| |.||.|    |..|. |.| .......|||||..||.|. .|. ..|..||...||.. .|| ..|.. |
lskpkvekesedesneelsygasamqGwrvsqEDah....ncitdlded.tslfavyDGHGGkevakyvakklpdllkaqkgykegdvekaleeaflalD

VKLLQDPVMKE
 || .. ..||
eklkaeeslke

PP2Cc_SM00332 14-290 1.4e-75 247.2 In-house 2-274 (274) alignment
Range on Protein: 14-290
Range on HMM: 2-274/274.0
SHSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLtksDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEG----NLPRALIDTFINTDVKLLQ
| || ..  ..|...||||| |||| |.  ...     ..  .|.|.||||||..||... .|..|.|.|.......    .  .|| . | .|| ..|.
sesgsnlglsygkssmqgwrksmeDahvvvvdlv...eeedwlffgvfDGhgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeile

DPVMKED---HSGCTATSILVSKSQnlLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPklGPE
.  .||.    ||.||...|..| .  |.. |.|||| ||...|.|..||.||||  ..|..|| .| |.|| .||||.||.|||.||...| |   ...
eeqskelenalsGstavvallkked..lyvanvGDSravlcrngkavqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkknk..klk

EQIVTCVPDILEHSLdYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGK--TLNEISSRIIDvCCAPTtegtGIGCDNMSIVVV
|...|. ||.  ..|  . |||.|||.||.||.|..|. ||.|.  |..||     |.. .... .....    | ..||...|||
epyitaepdvkvvtl.tsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaellde.eairr....ggseDniTvvvv

subfamily_PPM1A_pd Subfamily PPM1A 15-292 3.6e-74 242.6 In-house 5-280 (282) alignment
Range on Protein: 15-292
Range on HMM: 5-280/282.0
HSGADSLTAFGLCAMQGWRMSMEDSHILEPNVLtksDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFH--------EGNLPRALIDTFINTDVK
... .    .|. .|||||..|||.|.   ..       . .|. .||||.|..||.|. ....| . |.....        . ..  || . |...| .
sqaegnglrygvssmqgwrvemEDahtvvaslg...alkdwsfFavfDGHaGsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldea

LLQDPVMKE--DHSGCTATSILVSksQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSNPKLG
. ..   ..  |.||.||...|||  .. |.. |.||||.||. .|.|. |..||||. ..|| || .|.|.| ..||||.||.|||.||.|.|......
irelstdlktadksGsTavtvlvs..ekhliianlGDsRavlcrngkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeykeeeekk

PEEQIVTCVPDILEHSLDYDRDeFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTEgtgigcDNMSIVVVAL
.||| |. .|..   . . . | |..|||||||| |.... |.||.  |. .. |.|......| .    ..      ||.|..||..
aeeqlvsaepevtsierseedd.flvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsr......DNlsvlvvlf

subfamily_PP2D1_pd Subfamily PP2D1 23-84 1.3e-08 27.0 In-house 2-62 (492) alignment
Range on Protein: 23-84
Range on HMM: 2-62/492.0
AFGLCAMQ--GWRMSMEDSHILEPNVLTKSDKdhiAFYGIFDGHGGAKVAEYCGNKIVEILQEQ
|.|.|  .   |. .||| . |  . . . ..   .|.||.||. ||  || . ... |.| |.
avGiCedknsrWKskmeDkrtlqdyfgndvns...cFfgiyDGynGataAeiaakelhevllee

PP2C Protein phosphatase 2C 24-276 1.4e-86 283.2 Pfam-A 3-252 (255) alignment
Range on Protein: 24-276
Range on HMM: 3-252/255.0
FGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEG-NLPRALIDTFIN-TDVKLLQDPVM-KEDHSGC
.| ...||.|.||||.||...|   .|.|...||...|||||| ..|.|..... |||.|||||.|. .. .||...| . || .| ..  . ....||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TATSILVSKSQnlLVCGNAGDSRTVLATDGNAK-ALSYDHKPTLASEKSRIVAADGFVE-MDRVNGNLALSRAIGDFEFKSNPklgpeEQIVTCVPDILE
||...|.....  | . |.||||.||....||| .|..||||.  .|..|| .|.|.|. . ||||.||.|||.||||.|...     ||.|.. ||. .
tavvalirgkk..lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

HSLDYDrDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTE
..|... |||.|||.||.||.|..|..||||.  | ..|...|.. ...| ..|. .|
vkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse

PP2C Protein phosphatase 2C 24-276 1.4e-86 283.2 In-house 3-252 (255) alignment
Range on Protein: 24-276
Range on HMM: 3-252/255.0
FGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEG-NLPRALIDTFIN-TDVKLLQDPVM-KEDHSGC
.| ...||.|.||||.||...|   .|.|...||...|||||| ..|.|..... |||.|||||.|. .. .||...| . || .| ..  . ....||.
vgaselqgarksmedahialknlekssgkssvaffavfdghggreaakyarehleeilkeqksflelekvekalrksfladtdeelksskantepsksGs

TATSILVSKSQnlLVCGNAGDSRTVLATDGNAK-ALSYDHKPTLASEKSRIVAADGFVE-MDRVNGNLALSRAIGDFEFKSNPklgpeEQIVTCVPDILE
||...|.....  | . |.||||.||....||| .|..||||.  .|..|| .|.|.|. . ||||.||.|||.||||.|...     ||.|.. ||. .
tavvalirgkk..lyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpke.....eqlvsaePdvts

HSLDYDrDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCAPTTE
..|... |||.|||.||.||.|..|..||||.  | ..|...|.. ...| ..|. .|
vkltee.defliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargse

PPM_PTC7 24-276 2.2e-85 279.2 In-house 3-256 (259) alignment
Range on Protein: 24-276
Range on HMM: 3-256/259.0
FGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEG-NLPRALIDTFIN--TDVKLLQDPVM-KEDHSG
.| .|.||.|.||||.||...|.  .|.||..||...|||||| ..|.|..... |||.|.||| |. .| .||...| .  || .| ..  . ....||
ggasafqgfrksmedahialanlesssgkdsvaffavfdghggreaakyarehleeilkerksfeeleklekalrksflaldtdeelksseantepstsG

CTATSILVSKSQnlLVCGNAGDSRTVLATDGNAK-ALSYDHKPTLASEKSRIVAADGFVE---MDRVNGNLALSRAIGDFEFKSNPKlgpEEQIVTCVPD
.||...|...|.  | . |.||||.||...|||. .|..||||.. .|..|| .|.|.|.   . ||||.||.|||.||||.|....   ||| |.. ||
stAvvalitgsk..lyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpket...eeqlvsaePd

ILEHSLDYDrDEFVILACDGIWDCLTSQDCVDLVHLGLREGkTLNEISSRIIDVCCAPTTE
| .. .|.. |||.|||.||.||....|..||||.  | .. ...|.. ...| ..|. .|
isstkidee.defliLasdGlwdvvsdqeavdlvrselskk.dpmeaaeklvdeaiargse

0049733 PP2C-like 24-291 1.6e-50 164.6 In-house 5-232 (235) alignment
Range on Protein: 24-291
Range on HMM: 5-232/235.0
FGLCAMQGW-RMSMEDSHILepnvltksdkdHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQ-KSFHEGNLPRALIDTFINTDVKLLQDPVMK--EDHSG
.| . ..|. |  .||....           ........|||||. ..|.. . .||.|.|. ..... .| .||...|  ..  ||.  .     ...|
vgaasdigrvrkvneDavlv...........glllfavaDGhgghaagevasellvetllelllelllldleealrkaflaaneallelalaspelagmg

CTATSILVSksQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVemdRVNGNLALSRAIGDFEFKsnpklgpeeqivtcvPDILEH
.||. .|.   .. |.. |.|||| .| .||..  |..||.|.   |. ||..|.|.|   ||.| |||.||.||...|               ||. ..
tTavvalld..ggklyvanvGDsrayllrdgklvqltedhspvnelerqriitaggav...rvpgrlaltralGdlllk...............pdvtvl

SLDYDRdeFVILACDGIWDCLTSQDCVDLVHLglregKTLNEISSRIIDVCCApttegtGIGCDNMSIVVVA
 |. .   |..||.||.||.|.... |||..      ..|.|. .|... ..|      . |.||...||| 
elepgd..flllasDGlwdvlsdeeivdllrs.....ldleeaaerlvelala......rggrDNiTvvvvr

PPM_PTC7_SpoIIE 24-263 4.7e-47 153.7 In-house 3-214 (230) alignment
Range on Protein: 24-263
Range on HMM: 3-214/230.0
FGLCAMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKvaEYCGNKIVEILQEQKsFHEGN-LPRALIDTFIN--TDVKLLqdpvmkEDHSGC
.| .|.||.| ||||.||...|.  .|...  ...|..|||||     .. . . ..|.|.. |.... .  .|.... .  .| .        ...||.
ggasaaqgarksmedahispansekssggrlalvvgdvdGhGgra..alamgllrtalrela.faglekpeeilrrlnlalaadlede......psssga

TATSILVSKSQNLLVCGNAGDSRTVLATDgNAKalsydhkptlasEKSRIvAADGFVE----MDRVNGNLALSRAIGDFEFKSnpklgpEEQIVTCVPDi
||. .|.  |.. | . |||||. .| .| ...            |. || .| |...     .||.|.||.|.|.||. ..       ....|.. || 
TavvalidpstgklyvanaGdsppllvrd.dgg............ereri.vagglpslGilpgrvfgvlavslapGdlllly......tDGvveaepd.

LEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGktlneIS
 .. .....|||.|||.||.||.|..|..||||   | .      ..
tsdgelfgkdeflilasdglwdvlspqelvdlvrdelekp.....aa

Subfamily Dicty-PPM1L-like 24-82 2.7e-07 22.7 In-house 9-64 (305) alignment
Range on Protein: 24-82
Range on HMM: 9-64/305.0
FGLCAMQGWRMSMEDSHIlepNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQ
..| . .. |   || .    . ..  ....  ..|.||||.| . |||   |.|||. 
yelyvsansrkyqedrnk...vkislessqelslfGvfdGhnGdiaaeyvkkklveivn

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 25-250 8.5e-43 139.5 In-house 9-221 (255) alignment
Range on Protein: 25-250
Range on HMM: 9-221/255.0
GLCAMQGWRMSMEDSHILEPNVLTKSDKDHiafYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLPRALIDTFINTDVKLLQDPvmkeDHSGCTATS
| . | | | .|||. ..  .   |||.|.   | .|||||| . |... ...  ||.|    .. |  ..| ... ...... . |     . |.||.|
gfsdmiGrrptmedelviyGsfrdksdedy...yalfdGhgGraaakfaseelykilaelldlnnanPvkslkkaykeistqiserp....kfiGttaas

ILVSKsqNLLVCGNAGDSRTVLA-TDGNAKALSYDHKPTLASEKSRIVAADGFVEMD----RVNGNLALSRAIGDFEFksNPklgpeeqIVTCVPDILEH
.|. .  .  .  | |||| ||.  || || ||.||||.  ||. || .. |.|  .    ||||.||.|||.||  .  .|        |.  ||. . 
vliie..dkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsfl..eP.......fvvpdPdlsqs

SLDYDRDEFVILACDGIWDCLTSQDCVDLVH
   . .|.|.||||||||| .. .. |..| 
leiskkdkflilacdGiwdlisdeeaveiva

subfamily_PPM1E_pd Subfamily PPM1E 26-292 1.9e-47 154.7 In-house 8-262 (265) alignment
Range on Protein: 26-292
Range on HMM: 8-262/265.0
LCAMQGWRMSMEDSHILEPN--VLTK-SDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHEGNLpRALIDTFINTDVKLLQDPVMKEDHSGCTA
. |... |  ||| |.  ..   | . .|....||...|||||| . |.|  ... | | .|....|  . .|| ..| .|| ..||  . .. .||.||
iaavknkrrkmEDrhvaledlnelfelkdekeraffavfDGHgGveaakyaaahlhellvrqeklkedpa.ealkeafkltDerflqkaereklksGsta

TSILVSKSQnlLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFV---EMDRVNGNLALSRAIGDFEFKsnpklgpeeQIVTCVPDILEH
 ..|..|.|  |  .  |||...|  .|.|  |   |||    ||.|| .|.|.|   .. ||||.|..|||||| . |         . |.  .|. | 
vvvliekdq..lyvaWlGDsqallvrkgeavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklk.........pyvsgeadvaev

SLDyDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGK-TLNEISSRIIDVCcapTTEGTGigcDNMSIVVVAL
.|| . .|..||||||.|| .. .. |.||.  |..|. .|.|..  ...     . .|     ||...||| |
eld.gseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaa...keagss...Dnitvvvvfl

subfamily_PPM1L_pd Subfamily PPM1L 27-255 2e-41 135.1 In-house 10-238 (269) alignment
Range on Protein: 27-255
Range on HMM: 10-238/269.0
CAMQGWRMSMEDSHILEPNVltkSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQ----KSFHEG----NLPRALIDTFINTDVKLLQDPVMKEDHS
 ...| |  |||  ..| ..   ..| .. |...||||||   ||.. ...|. ....    .. .|     |  . | |  .  | |||.    .|| .
ysvlGrrprmedrfeieedi...knktgesffavfdGhGGefaaefakdvlvkaiknklieldadkentepinfsklltdeilsvdekllekakraedia

GCTATSILVSKSQnlLVCGNAGDSRTVLA-TDGNAKALSYDHKPTLASEKSRIVAADGFVEMD---RVNGNLALSRAIGDFEFKsnpklgpEEQIVTCVP
|.||   ||..|.  |.  | |||| ||  ..|.|  ||.||||    |. ||  | ||. ..   ||.| || |||.||. .|       ....|   |
Gttalialvqesd..livanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplk.......dknlviadp

DILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLRE
|||   ||  . ||.|||.||.||... .. |  ..  | |
diltfdlddhkpeflilasdGlwdtfsneeavrfikerlke

subfamily_PPM1D_pd Subfamily PPM1D 28-292 2.4e-32 105.2 In-house 8-307 (309) alignment
Range on Protein: 28-292
Range on HMM: 8-307/309.0
AMQGWRMSMEDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHE---GNLPRALIDTFINTDVKLLQD----PVMKED-H--
| || |  |||   .  .   .. . . || ..|||||| . |..  ..... ...|| |      .. .|. ..|..|  .. .     |  |.     
adqGgrkymeDvvaivleeeesaeelevafvavfDGHGGkeAakfarehlwsvikkqkkflssepedvleAireaflatheamkkkleeWpktksgllst

SGCTATSILVSKsqNLLVCGNAGDSRTVLATDGN------AKALSYDHKPTLASEKSRIVAADGFVEMD----RV---------NGN--------LALSR
.| ||. ... .  . |  .. |||..||... .      || |  ||||   .|| ||  . | | .     ||         ||.        ||..|
aGttasvviirr..eklyvahvGDsaivlgvkepkekklrakeltkdHkPespeekerieelGGevaaksGvkRvvWkRprlehngptvideiPFLavaR

AIGDFeFKSNPKLgpEEQIVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDV---CCAPTTEGTGIGCDNMSI
..||. .  | |   .| .|  .||. .. || ....|.||| ||.|..||..| |..|.     ... .| |. .  .   .   ...   . .||.|.
slGDl.Wsynaks..gefvvsPePdvkvrtldpneekfiilasDGlwnvltpedavsvvekeeekkelkeeqsrsvakalvkealqrwrskklraDnvsv

VVVAL
.|| |
ivvil

subfamily_ILKAP_pd Subfamily ILKAP 29-255 1.8e-39 128.6 In-house 12-245 (293) alignment
Range on Protein: 29-255
Range on HMM: 12-245/293.0
MQGWRMSMEDSHILEPNVLTK--SD---KDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQ-----KSFHEGNLPRALIDTFINTDVKLLQDPVMKED--
 .| |  |.|.|..  .. ..   .     ....|..||||.| . .|.. .|. . . |.      | .| .. ..|.|.| .|| ..|.    ..   
rkGereemqdahviledldeqlrlekslvsrvsyyavfdGhaGsrasefaaeklhkkileklpksdvsakekeikkclvdsfkktdeefLklaskakPvW

HSGCTATSILVSksQNLLVCGNAGDSRTVLATDGNAK------ALSYDHKPTLASEKSRIVAADGFVEMDRVNGNLALSRAIGDFEFKSnpkLGpeeqiV
  |.|||..||   .|.|  .| |||..||.   ..       .|. ||.|.   |. ||  | |.|. .||.| |  ||.||| .||.   ||     |
kdGstatvvlvl..dnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkr...lG.....v

TCVPDILEHSLDYDrDEFVILACDGIWDCLTSQDCVDLVHLGLRE
...||.    |. . | ||.|||||.|. .. .. |. .   | .
istPdvkkceLten.dlfvvlaCdGLwkvfsadevvkfilkvled

subfamily_KAPP-like_pd Subfamily KAPP-like 31-292 5.8e-27 87.4 In-house 7-266 (266) alignment
Range on Protein: 31-292
Range on HMM: 7-266/266.0
GWRMSMEDSHILEPNVLTKSD---KDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQ---KSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATS
|  . ||| ..    .| . .     .||....|||| |  .|.   . . ..|...      ..|  .       ..  .| ..  . . .. |.||| 
gcstemedvslaiypllkekklsncsnialfavfdGhaGkGaadaakklfpkelekllkstkqddGGdniydqskllenafkevdaklkdfeyeGatatl

ILVSK--SQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAaDGFV---EMDRVNGnLALSRAIGDFEFKSNpKLGpeeqiVTCVPDILEH
 || .   | .| ..| ||| . |.   ..  ||.||| .  .|| ||   ||     .  |.|| ||.|||.||   |    .|     ..  | . ..
alvwsdGqqrylqvanvGdssaflsrGneslelskdhkakdpeekqrikd.dGitlsdnqtrinG.lavsralGdhfikel.niG.....lisepyvsnr

SLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCaptteGTGIGCDNMSIVVVAL
 |    |.|.|.| ||.|| .. .| .. |.    ...| ....| ....       ..    ||.|..|| |
illtpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletai.....qsikakdnvsvivvkl

subfamily_Dicty-PPM-1_pd Subfamily Dicty-PPM-1 31-292 4e-23 74.7 In-house 6-276 (276) alignment
Range on Protein: 31-292
Range on HMM: 6-276/276.0
GWRMSMEDSHILEPNVLTKSD---KDHIAFYGIFDGHGGAKVAEYC----GNKIVEILQE-Q---KSFHEGNLPRALIDTFINTDVKLLQDPVMKEDHSG
|  . ||| ..    .| . |     .||....|||| |  .|.       ...  .|.  .      ..|  .       ..   | ... . . .. |
gcstemedvslaiyplldekdlsncsnialfavfdGhaGkGaadaakklfpkelekllksgnysltkqddGGdniydqskllldlfkevdaklkdfeyeG

CTATSILVSK--------SQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAaDGFV---EMDRVNGnLALSRAIGDFEFKSNpKLGpeeq
.|||  || .         |  | ..| ||| . |.   ..  ||.||| |  .|| ||   ||     .  |.|| ||.|||.||   |    .|    
atatlalvwsdGeeqqqqqqrylqvanvGdssaflsrGneslelskdhkatdpeekqrikd.dGitlsdnqtrinG.lavsralGdhfikel.niG....

iVTCVPDILEHSLDYDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRIIDVCCaptteGTGIGCDNMSIVVVAL
 ..  | . .. |    |.|.|.| ||.|| .. .| .. |.    ...| ....| ....       ..    ||.|..|| |
.lisepyvsnrilltpfdkflivasdGlwdvisGkdaiekvkslydqqatedkmasslletai.....qsikakdnvsvivvkl

subfamily_TAB1_pd Subfamily TAB1 37-108 2.7e-06 19.4 In-house 9-83 (333) alignment
Range on Protein: 37-108
Range on HMM: 9-83/333.0
EDSHILEPNVLTKSDKDHIAFYGIFDGHGGAKVAEYCGNKIV-EILQEQK--SFHEGNLPRALIDTFINTDVKLL
...|  | .|.. . ....  |..|||. |.|.|..  ...| |.|.||   ...| .  . |   | ... |.|
kedhevedkvflfktendpilyavFdGydGnkaakfveqrLvaellleqltdelaeaevkevlkrafeeverkfl

subfamily_PPM1K_pd Subfamily PPM1K 49-266 6.3e-36 116.8 In-house 25-238 (263) alignment
Range on Protein: 49-266
Range on HMM: 25-238/263.0
KSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKsFHEGNLPRALIDTFINTDVKLLQDPVM-----KEDHSGCTATSILVSKSQNLlVCGNAGDSR
|  .... ....||||.|.  |... .|. .||.. .  .| .|   | ..| . | || .   .     ..  || |||  |. . ..| |  . ||||
keldpellyvavfdGhaGsaaadfvhdklekilkrll.ekekdleivlknafeeldkklkrylefsvaeaellssGttatvsllrdGtel.vlaslGdsr

TVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEM-----DRVNGNLALSRAIGDFEFKSNpklGpeeqiVTCVPDILEHSLDYDRDEFVILACDGIWD
..|  .|.|| |. ||.| |  || || ||.|.||.      .||| ||..|..||...|.    |     |   |.  .  .|...| |..|  ||| .
ailcrnGkakkltrdhdPeleeekerikaagGsvewnslgkplvngrlamtrslGdldlkry...G.....viatPetkslkvdhaadsflvlitdgisf

CLTSQDCVDLVHLGLREgktlNEISSRI
 ..||.  |||.|        .| .. .
vvnsqelcdlvrlchdp....eeaahal

PP2C_SIG_SM00331 49-291 5.1e-12 38.8 In-house 24-216 (217) alignment
Range on Protein: 49-291
Range on HMM: 24-216/217.0
KSDKDHIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHegnlpRALIDTFINTDVKLLQDpvMKEDHSGCTATSILVSKSQNLLVCGNAGDSRTVLAT
 .....  .. ..||.|. . |. .  .... |.|. | .      .| ... ...  . .    .|.....|.. .|.  |.. |   |||||| .| .
vklnegrlllvvaDgmGkGlaAaaassqlrtalrellseg.....eelsqalkrlnraiyee..keekgmfaTlllalydfssgklsyanaGdsrpyllr

DGNAKALSYDhkptlaseksrivaadgfvemdrvngnlalsraigdfefKSNPKLGPEEQIVtcvpdILEHSLDYDRDEFVILACDGIWDCLTSQ----D
||. .    |                                       .. . || |...      . ...|... .....|. ||...  ...    .
dgklveilkd.......................................vegaplGlepevs.....vdirelelekgdllllytDGltearsekgfaee

CVDLVHLGLReGKTLNEISSRIIDVCCAPTTEGTGigCDNMSIVVVA
 . ..   |  . .. |....|..  .. ...  |   |....||| 
rleeiledlv.dseaqelaqkiveellelakgsng..eDdiTvvvvk

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 54-198 8.3e-18 57.9 In-house 19-186 (292) alignment
Range on Protein: 54-198
Range on HMM: 19-186/292.0
HIAF-YGIFDGHG--GAKVAEYCGNKI-VEILQEQKsfHEGNLPRALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSKSQNlLVCGNAGDSRTVLAT-
 ..|   ..||||  | |||..  ... ||.|.  .  .  .|. ||.   ...  || .  . .  ... ...   |   .. |.  | ||||..|   
altflaavldGhGvnGdkvaqlaedtlevelleltr..qlqelsealllrildiaakldkltidaresattavvcarvrddra.lilanvGdsrallgrc

----DGNAKALSYDHKPTLASEKSRIVAADGFVE-----------MDRV------NGNLALSRAIGDFEFK
    | . . || ||||    |..|| .| |.||             ||      .|.||||||.||| ..
lggsdyeliPlsrdhkPedPderarilraGGrveptrvrgwgfrGtarvwrrrqqeGdlalsralGdfhlf

subfamily_PHLPP_pd Subfamily PHLPP 54-250 2.3e-08 26.2 In-house 26-213 (246) alignment
Range on Protein: 54-250
Range on HMM: 26-213/246.0
HIAFYGIFDGHGGAKVAEYCGNKIVEILQEQKSFHeGNLPRALIDTFINTDVKLLQdpvmKEDHSGCTATSILV--SK----SQNLLVCGNAGDSRTVLA
. | ||.|||.   ....   . . ..|.|. .    |    .  |.. .  || .    . .. | .|  ||.  .|    .   |   . |   .||.
vealyGlfdGdrneelssllqrlmkdvlkeevqkd.kneeeymkntllvaqrklGe....aGeklgsaallilirhdkvdPaksfsLevAsvGtlqavli

TDGNAKALSYDHKPTLAsEKSRIVAADGFVEM-DRVNGNLALSRAIGDFefKSNPKLGPEeqivtcvPDILEHSLDYDrDEFVILACDGIWDCLTSQDCV
 .|.   ||  ..     | .||  | ....  ...|| .. .| .| .     | . |.       | . |  |  . ||..|.  . .|. |  .. |
Rngkklrlsksyviekd.elkrikeakaiitednkingviestrllGyt..flfPvvlPk.......phvrevlLteq.dellivGnkalWevlsideav

DLVH
. |.
eavr

Subfamily Dicty-PPM1L-like 95-200 2.9e-12 39.1 In-house 192-295 (305) alignment
Range on Protein: 95-200
Range on HMM: 192-295/305.0
ALIDTFINTDVKLLQDPVMKEDhsGCTATSILVSKSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADG-----FVEMDRVNGNLALS
||....   . .||.    | |  . .   .   . ..|||  .|.|.. |||||| ...|||....    |. |.   ..     | |. || ...|..
alynygellvnrllkksrskGd..knlkelviPnndspllvvakanDqflvlatdGlwevlsyqdvveevkellrdkssqkkiewdfneisrviveeavk

RAIGDfefksN
| .||     |
rgsgD.....n

subfamily_PPM1H_pd Subfamily PPM1H 95-170 1.3e-09 30.4 In-house 139-210 (404) alignment
Range on Protein: 95-170
Range on HMM: 139-210/404.0
ALIDTFINTDVKLLQDPVMKEDHSGCTATSILVSksQNLLVCGNAGDSRTVLATDGNAKALSYDHKPtlASEKSRI
|| . |.. | .. ..    ... |||| . ||   .. |   |||||| .| . .. ..|| |. |  ..|. |.
alesaflemDeqiarereayrikGGCtalvalvl..lgklYvanaGDsRailvrkdeiiplsadftP..eteRqRl

subfamily_PDP_pd Subfamily PDP 106-267 1.1e-16 53.9 In-house 141-326 (398) alignment
Range on Protein: 106-267
Range on HMM: 141-326/398.0
KLLQDpVMKEDHSGCTATSILVSKSQnlLVCGNAGDSRTVLAT---DG--NAKALSYDHKPTLASEKSRIVAAD------GFVEMDRVNGNLALSRAIGD
| |.. ...   || .|.  |... .  |   |.||.|.||..   .|  .|..|| |.  . ..| .|| ..         .  .|. |.|. .|| ||
kslre.allvalsGacallaliegte..lhvAntGDcravlgvqeeegsweavkLskdqtadneeEveRikkeHPgeesktvirngRlLgeLqPlRAFGd

FEFKSNPKLGP---EE------Q--------IVTCVPDILEHSLDyDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEISSRII
...| . .|     |.      .         .|  |....| |   .| |..|| ||.||.|.... |.||.  | . |. ......  
vryKwseelqkkvlekaylkvlepkdyktPPYltaePevtshklr.endkFLvlatDGLwdllsneevvslVgehlakkkekepvkveea

subfamily_PPM1G_pd Subfamily PPM1G 117-292 1.5e-60 198.5 In-house 295-470 (473) alignment
Range on Protein: 117-292
Range on HMM: 295-470/473.0
HSGCTATSILVSKsqNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVEMD-RVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPD
 ||.||. .|. .  . |.  ||||||.||. .|.|  ||.||||    |..|| .| | |..| |||| | ||||.||. .|.| .|...||... .||
dsGttAvvaLlke..kklivAnaGDsRcvlsrnGkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPD

ILEHSLDyDRDEFVILACDGIWDCLTSQDCVDLVHLGLREGK--TLNEISSRIIDVCCAPTTEGTGIGCDNMSIVVVAL
|  . |  . |||..|||||||....||. || |.  |..|.  .|.||  ...| | || |.| | |||||....| |
ikvltlt.eedeFlvlAcDGiWnvmesqevvdfvraklkkgeesvlseiveeLlDaclapdtsgDGtGCDnmtviivll

subfamily_PP2D1_pd Subfamily PP2D1 129-385 1.9e-15 49.6 In-house 185-414 (492) alignment
Range on Protein: 129-385
Range on HMM: 185-414/492.0
KSQNLLVCGNAGDSRTVLATDGNAKALSYDHKPTLASEKSRIVAADGFVE----MDRVNGNLALSRAIGdfeFKSNPKLgpeEQIVTCVPDILEHSLDyD
. . .|   |||. . ||  .|.|. |  .| |    |..|.  | . |     . .||| |   | .|   .  .|||   .. | . | .    || .
eelgvlyianaGnvqAvLcreGkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLG...nyGdpkL...kksvipePkttsvkld.e

RDEFVILACDGIWDCLTSQDCVDLVHLGLREGKTLNEiSSRIIDvccapttegtgigcDNMSIVVVALLKEgEDVAQWSDRMKSKAHRTSVRSFADKrrr
.. |..||  |.|. |. .. . ||.  |.  |   . .  . |               ... |    | |  .. . | |.......  |.|  |    
aaqflvlAsnGlWevlseeevlsLvkqtlaiyksrvr.aenvpd..............sdvttvgedylgE.leakklsaryentgfdkfvtseidl...

vfsyyDFSKCNDEQVFAITTKKPQDKFTRDHEAAVASVTAADNDDPMDIDDTDADTDAENL
     | .. .. ... . . .. .. ..| .   ..   |     .   . |.|..||. 
.....daaegdesnlqklfsynelsevkedaddereglseanskkeityneedtdksaees

subfamily_PPM1H_pd Subfamily PPM1H 180-253 3.6e-07 22.3 In-house 275-351 (404) alignment
Range on Protein: 180-253
Range on HMM: 275-351/404.0
DRVNGNLALSRAIGDFEFKSNPKLGPEEQIVTCVPDILEHSL---DYDRDEFVILACDGIWDCLTSQDCVDLVHLGL
 |. . .. .| .|| | |   .      ....||..    |   . ..|. .||| ||.|| |. ..   .|.  |
aRllatigvtRGlGDheLkvvdtnlsikPfLspvPevrvldltqvesleDdvlilatDGLWdvlsneevaeivrevl

PPM_PTC7_SpoIIE_motif 218-291 6.3e-08 26.2 In-house 4-79 (81) alignment
Range on Protein: 218-291
Range on HMM: 4-79/81.0
EHSLDYDRDEFVILACDGIW-------DCLTSQDCVDLVHLGlrEGKTLNEISSRIIDVCCApttEGTGIGCDNMSIVVVA
|.....  .. ..|..||..       .... .. ..|..    |||.| |.. ...| . .    | |   |.....|. 
eaefqLkpgdvllLyTDGltEardsdgelfgkeellrladra..egkslqeladklvdevle...ngsgereDDitllvlr

PPM_PTC7_motif 230-277 1.9e-16 53.3 In-house 1-49 (51) alignment
Range on Protein: 230-277
Range on HMM: 1-49/51.0
ILACDGIWDCLTSQDCVDLVHLGLR-EGKTLNEISSRIIDVCCAPTTEG
|||.||.||.|..|..||||. .|  .|....|......| ..|. .| 
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseD