Gene PPT1 in Saccharomyces cerevisiae

Synonym: CMP1, YLR433C, CNA1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP5C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP028_AA protein Get Run
ScerP028_AA_188-508 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
TPR_11 TPR repeat 11-77 1.3e-19 59.3 Pfam-A 2-69 (69) alignment 
Range on Protein: 11-77
Range on HMM: 2-69/69.0
KALERKNEGNVFVKEKHFLKAIEKYTEAIDLDSTQSIYFSNRAFAHFKV-DNFQSALNDCDEAIKLDP
.|.. |..||.. ||. . .|||.|..|..||.   ....|.| |..|  .....|| |...|..|||
nAealkelGnalfkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_2 Tetratricopeptide repeat 48-79 3e-08 22.9 Pfam-A 3-34 (34) alignment 
Range on Protein: 48-79
Range on HMM: 3-34/34.0
YFSNRAFAHFKVDNFQSALNDCDEAIKLDPKN
.  |.. |..| .... ||.....|..|||.|
alynlGlayyklgdyeeAleafekAleldPnn
TPR_1 Tetratricopeptide repeat 49-79 3e-09 25.9 Pfam-A 4-34 (34) alignment 
Range on Protein: 49-79
Range on HMM: 4-34/34.0
FSNRAFAHFKVDNFQSALNDCDEAIKLDPKN
. |.. |..|  ... || ....|..|.|.|
lynlGnaylklgkydeAleyyekALelnPnn
TPR_16 Tetratricopeptide repeat 52-114 6e-07 19.7 Pfam-A 3-65 (65) alignment 
Range on Protein: 52-114
Range on HMM: 3-65/65.0
RAFAHFKVDNFQSALNDCDEAIKLDPKNIKAYHRRALSCMALLEFKKARKDLNVLLKAKPNDP
.| | ..  ... ||.  ..|..|.|..  |. ..| ..... ....|.. |. .|.. |.||
lArallraGdydeAlaaleaalalaPeaaeallllaeallrqgrldaAaallraalalaPddp
TPR_9 Tetratricopeptide repeat 55-119 6.5e-08 21.8 Pfam-A 4-68 (73) alignment 
Range on Protein: 55-119
Range on HMM: 4-68/73.0
AHFKVDNFQSALNDCDEAIKLDPKNIKAYHRRALSCMALLEFKKARKDLNVLLKAKPNDPAATKA
...  . |..||. ..  . |.|     .  |.|  . | ..  |..||.  |.  |..|.| ..
iylreedferALavverllllaPddpyerRDrGlllaqlgclaaAledLeaflelcpdapdaeli
TPR_11 TPR repeat 57-111 5.2e-10 28.5 Pfam-A 14-69 (69) alignment 
Range on Protein: 57-111
Range on HMM: 14-69/69.0
FKVDNFQSALNDCDEAIKLDPKNIKAYHRRALSCMALL-EFKKARKDLNVLLKAKP
||  ... |.  ...|..|||.| ..| ..||. . |  ....|..|..  |.  |
fkegdydeAieayekAleldpnnaelyynlAlaylklgkdyeeAledyekAleldP
TPR_19 Tetratricopeptide repeat 60-117 9.8e-08 21.3 Pfam-A 5-62 (68) alignment 
Range on Protein: 60-117
Range on HMM: 5-62/68.0
DNFQSALNDCDEAIKLDPKNIKAYHRRALSCMALLEFKKARKDLNVLLKAKPNDPAAT
 ....||.  ..|...||.|  |. . |  ..|| ....|.. |. |....|.||.. 
gdyaeAlkllkqalqedpqnaearllLAeallalgqldeAealLdtlplqdpddpryq
NBP1 Fungal Nap binding protein NBP1 93-170 2.9e-07 16.2 Pfam-A 99-174 (323) alignment 
Range on Protein: 93-170
Range on HMM: 99-174/323.0
LLEFKKARKDLNVLLKAKPNDPAATKALLTCDRFIREERFRKAIggAENEAKISLCQTLNLSSFDANADLANYEGPKL
| |.|.| .|||.||| ...|.  ..  |  || .| |.|.| .   | .    | . |  .| . . .  . .. .|
lsemkrasedlnkllkkseadeereerdlikdrilrseaFkkkl..lEkkydkrlleeLrrgssktrsnrerksslnl
PPP5 PPP5 TPR repeat region 122-175 2.3e-06 18.0 Pfam-A 4-52 (95) alignment 
Range on Protein: 122-175
Range on HMM: 4-52/95.0
TCDRFIREERFRKAIGGaeNEAKISLCQTLNLSSFDANADlanYEGPKLEFEQL
 |.. ... .| |||    .|.|.|  ......| . ..|   |.||.|| |..
eCeklvkkiaFekAIev..deekrsvaesidiesieiedd...Ydgprledekv
subfamily_PPP5C_pd Subfamily PPP5C 180-508 8.5e-156 510.9 In-house 4-321 (322) alignment 
Range on Protein: 180-508
Range on HMM: 4-321/322.0
NAFKGAKIKN--MSQEFISKMVnDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVELENNSTPdvKISVCGDTHGQFYDVLNLFRKFGKVGPKHTYLFNG
. ..| |...  ...||..... .|| | |.|.|||...|...|..|....||.||.....|   |..||||.||||||.||.|...|.......|||||
dsydgpkleeekitkefvkell.elfkkqkklhkkyalkilleakellkklpslveitieetk..kltvcGdihgqfydllnifelnGlpseenpylfnG

DFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPSATLSDFKNID
|||||||.|.||.|.....|.|.||.|||.|||||||||||.||||.|.|.||.......|...|..||||..||...||.||||.|....||.|...||
dfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkid

RFAQPPRDGAFMELLWADPQEANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVvpghgi
|.||||..|...||||.|||||||..||.||.|..||||.|..||..|.|..|.||||... |...|..|||.||||||||||..||.|..|..      
rnaqppeegllvellwsdpqeanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitl......

lqagRNDDQNLIIETFEAVEHPDIKPMAYSN
    |.||..| ..|||||||||.|||||.|
....rgddlklkfktfeavehpdvkpmayan
PPP5 PPP5 TPR repeat region 180-234 2.4e-09 27.5 Pfam-A 40-95 (95) alignment 
Range on Protein: 180-234
Range on HMM: 40-95/95.0
NAFKGAKIK--NMSQEFISKMVNDlFLKGKYLPKKYVAAIISHADTLFRQEPSMVEL
. ..|...   .. .||. ..... | |.| | ||.| .|. . ..|....||.||.
ddYdgprledekvtlefvkellee.fkkqkklhkkfvyqilldvkellkklpslvei
subfamily_PPP7C_pd Subfamily PPP7C 181-378 4.9e-46 150.2 In-house 5-201 (383) alignment 
Range on Protein: 181-378
Range on HMM: 5-201/383.0
AFKGAKIK-NMSQEFISKMVNDlFLKGKYLPKKYVAAIISHADTLFRQEPSMVELENNSTpdVKISVCGDTHGQFYDVLNLFRKFGKVGPKHTYLFNGDF
 ..| ...  .... ..|.... | . | |  |||. |.  |   ..| |.. ...   .   ...|||| ||.. |.| .. | |   ....|.|||||
sytgprlslpltkdevekliea.fkekkllhakyvllilreakkvlkqlpnisrvstais..kevtvcGdlhGklddlllilyknGlpseenpyvfnGdf

VDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKY---SQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDpSATLSDFKNI
||||. | |..|....| ...|....|||||||   .|  |||  | . ||   ...| ... . |  |||||||... |..|||. || .. |. ...|
vdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGi.sd.ktdlelldki

DR
.|
er
0049330 Metallo-dependent phosphatases 189-473 1.2e-85 280.4 In-house 11-287 (309) alignment 
Range on Protein: 189-473
Range on HMM: 11-287/309.0
NMSQEFISKMVnDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVELEnnstpdVKISVCGDTHGQFYDVLNLFRKFGKVGPkHTYLFNGDFVDRGSWSCE
.. ........ .|.||.|.|.....  .. .| .....||...||.       .| |.|| |||..| |.|..|.| ... ....|.||.||||..|.|
elilslldlli.elllklkllseeellllllkakeilksepnllels......mrivviGDiHGqlddLlrllekigfppe.drlvflGDlvdrGpdsle

VALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPsATLSDFKNIDRFAQPPRDGAF
| || ..||.|.|.|.|| |||||. ..| .||| ||...||.......| . ..||||| .|....|..||||..|   .|.......|. ..| || .
vlllllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdl.llldqirelerpleipldgll

MELLWADPQ-EANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVVP
..|||.||. . .| .|..||||. ||.....|||. |.|. |.|.|.. .||...  .|||.|||||||||.  ||||.|... .
cdllwsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleide
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 192-471 8.9e-69 224.8 In-house 8-280 (298) alignment 
Range on Protein: 192-471
Range on HMM: 8-280/298.0
QEFISKMVNDLFLkGKYLPKKYVAAIISHADTLFRQEPSMVELENnstPdvkISVCGDTHGQFYDVLNLFRKfGKVGPKHTYLFNGDFVDRGSWSCEVAL
 |..|. ...  |  | . .. |  .|..|  .|.. .|.||...   |   |.|||| |||. |.| || | ..  |.. ||| ||.||||. . || .
ievlsvslsekkl.tkvikeedveklielakkifkkqkslvevda...p...ikvcGdihGqysdllrlfdk.agfppdanylflGdyvdrGrqnleviv

LFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKY-SQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPPRDGAFME
|. . |. .|||||| |||||   .|..||| .||| .| |.|... | . |..|||..|| .  | ||||| |.   .|...... |  ... .   ..
lllaykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGl.skklksldqlrelkrpfdskeeslaid

LLWADPQE-ANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
||||||..  .|. ...|| .  || |    .| . ..  . |.| .   | .|  . ||.|.||||.||..  |  .|..|
llwadpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkv
subfamily_PPP3C_pd Subfamily PPP3C 196-471 1.9e-71 234.2 In-house 28-309 (452) alignment 
Range on Protein: 196-471
Range on HMM: 28-309/452.0
SKMVNDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVELENnstPdvkISVCGDTHGQFYDVLNLFRKFGKvGPKHTYLFNGDFVDRGSWSCEVALLFYC
 ..... |||   | .. .. ||..| .|...|....|.|    |   | |.|| ||||||.|.||   |.   . .||| ||.||||..|.|. | .|.
levlkehflkegrleeeaalkiieeaakllkkektllevea...P...itviGdihGqfydllklfevgGd.PastkylflGdyvdrGyfsiecvlylya

LKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDpSATLSDFKNIDRFAQPPRDGAFMELLWAD
||| .|...|| |||||.  . . . |..|||.|||....... .||.|||||.|.|. .| .|||| ..   .| | |..||| .||  |.. .|||.|
lkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspe.ikslddikkldrfkeppasGplcdllWsd

PQEANGMGP--------SQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQK------GKLMTVFSAPNYCDSQGNLGGVIHV
| |  |           | ||  ....   . .||..|.|  | |.|| .  | .  .|        |.|.||||||.|.  | . |...
PledygeekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlky
0045823 Metallo-dependent phosphatases 197-508 1.7e-95 313.4 In-house 31-336 (473) alignment 
Range on Protein: 197-508
Range on HMM: 31-336/473.0
KMVNDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVELENnstpdvKISVCGDTHGQFYDVLNLFRKFGKVGPkHTYLFNGDFVDRGSWSCEVALLFYCL
. . . ..|...||....  ... |  ....||...||.       .| |.|| |||..| |.|..|.|  ..  ...|.||.||||..| || .| ..|
dlliehlkkegllpeedllklldeakeilkkepnllelsm......rivviGDiHGqlddLlrllekigfppe.drlvflGDlvDrGpdslevlelllal

KILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPsATLSDFKNIDRFAQPPRDGAFMELLWADP
||..|.|.|| |||||. ..| .||| ||. .||.......| . ..||||| .|.. .|..||||..|   .|.. ..|.|. ..|.||....|||.||
kikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdl.plldqireierpleipddgllldllwsdP

QEANG--------MGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGK------LMTVFSAPNYCDSQGNLGGVIHVvpghgilqagr
.| .|        .|.|.|| |. ||||....||..|.|. |.|.|. ...|...  .||      ..|||||||||.  |||..|...           
weddgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvi...........

NDDQnLIIETFEAVEHPDIKPMAYSN
..|  . . .|....|| |.|.....
dedl.isfiqfdpsphplilplfldv
0053225 Metallo-dependent phosphatases 197-472 1.4e-80 263.8 In-house 10-278 (293) alignment 
Range on Protein: 197-472
Range on HMM: 10-278/293.0
KMVNDLFLKGKYLPKKYVAAIISHADTLFRQEPSMVELEnnstpdVKISVCGDTHGQFYDVLNLFRKFGKVGPkHTYLFNGDFVDRGSWSCEVALLFYCL
... .|.|. |.|.....  .. .| .....||...||.       .| |.|| ||...| |.|..|.| ...  ...|.||.||||..| || .|...|
dllielllllkllseeelllllleakeilkkepnllels......mriyviGDiHGnlddLlallekigfppe.drlvflGDlvdrGpdslevlelllal

KILHPNNFFLNRGNHESDNMNKIYGFEDECKYKY-SQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPSaTLSDFKNIDRFAQPPRDGAFMELLWAD
|.|.|.|..| |||||. ..| .||| ||...|| ........ . ..||||| ||....|..||||. | | .|.. ..|.|. ..| .|....||| |
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdls.lldqireinrplriplegllldllwsd

PQEANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVV
|.. .|..||.||||. ||.....|||..|.|. | |.|.. ..|...  .|||.||||||||..  ||||.|... 
pdlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlald
subfamily_PPP2C_pd Subfamily PPP2C 204-471 1.3e-70 230.9 In-house 12-272 (290) alignment 
Range on Protein: 204-471
Range on HMM: 12-272/290.0
LKGKYLPKKYVAAIISHADTLFRQEPSMVELEnnstpdVKISVCGDTHGQFYDVLNLFRKFGKvGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNN
 ..| | .. |.... .|  ....|  . |..      . ..|||| ||||.|.|.||.  ||  |.  ||| ||.|||| .| |   |. .||. ... 
keckqleesevkelcekakeilskesnvqevk......cpvtvcgdvhgqfhdllelfkiggk.spdtnylflgdyvdrgyysvetvtllvalkvryker

FFLNRGNHESDNMNKIYGFEDECKYKYSQ-RIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQEANGM
  . |||||| .. ..||| |||  ||..  ....|.. |. |||..|.... ...|||| |    || . ...||. . |..|.. .|||.||.. .|.
itilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhggl.spsidtldkiraldrlqevphegplcdllwsdpddrggw

GPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
| |.|| |..|| ||...| ..|.|. | |.|.| | | ..  . ...|.|||||||   || .... .
gisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailel
subfamily_PPP6C_pd Subfamily PPP6C 205-471 7.1e-68 221.8 In-house 11-270 (290) alignment 
Range on Protein: 205-471
Range on HMM: 11-270/290.0
KGKYLPKKYVAAIISHADTLFRQEPSMVELennSTPdvkISVCGDTHGQFYDVLNLFRKFGKVgPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNF
| ||||.. . .. ..   |. .| ... .   |.|   ..|||| ||||||...|||. |.| |. .|.| ||||||| .| |   .. .||. .|.. 
kckylpendlkklcdlvldllleesnvqpv...ssp...vtvcgdihgqfydleelfrtggqv.pdtsyvflgdfvdrgyysletftrlltlkakypdri

FLNRGNHESDNMNKIYGFEDECKYKYSQ-RIFNMFAQSFESLPLATLINNDYLVMHGGLPSDpSATLSDFKNIDRFAQPPRDGAFMELLWADPQEANGMG
 | |||||| .. ..||| |||. || .   .. ... |. |..|..|... | .|||| .|   || . . |.|  . |..||| .|.|.||.. .   
tllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspd.vktldqirvieraqeiphkgafcdlvwsdpedvetwa

PSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
 |.|| |. ||  .|. |...|.|. | |.|.| . |...  . ||.||.||||||   ||.  ....
vsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilal
subfamily_PPG1_pd Subfamily PPG1 205-471 9.5e-63 205.2 In-house 10-282 (300) alignment 
Range on Protein: 205-471
Range on HMM: 10-282/300.0
KGKYLPKKYVAAIISHADTLFRQEPSMVELEnnsTPdvkISVCGDTHGQFYDVLNLFRKFGKVgPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNF
| . ||.  | ... .   |. .|  ..|..   .|   ..| || ||||||||..|.  |.| |   ||| ||.|||| .| |   |. .||. .|   
kaellpevtvkeltdklkellvkesnvieir...sp...vtvvgdvhgqfydvleifkiggqv.pdtnylflgdyvdrglysvetisllivlklrypsri

FLNRGNHESDNMNKIYGFEDECKYKY--SQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQEA---
 | |||||| .. ..|||  ||  ||   .|... ... |. | ||..|...  ..|||| |    .. . | .||| . |..||. .|||.||.|    
tllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhggl.spsvlsidqikvldrfrevpnegaladllwsdpeennnp

-------NG--MGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
       .|  .  |||| |...| |.. .|||||....|.|.|.| . | |    .|| ||.||||||   ||   .. .
tldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilel
PPP_3 209-473 1.8e-91 298.9 In-house 2-260 (271) alignment 
Range on Protein: 209-473
Range on HMM: 2-260/271.0
LPKKYVAAIISHADTLFRQEPSMVELEnnstpdVKISVCGDTHGQFYDVLNLFrKFGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNR
|... .. .....  .. .|...||..       .. ||||.|||..|.|.|| | |.  |...|||.||.||||..|.|| ||...|||..|....|.|
lsenelkelvkklkeilekesnlveis......apvtvcGDiHGqldDLlelf.knggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlR

GNHESDNMNKIYGFEDECK-YKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPSaTLSDFKNIDRFAQPPRDGAFMEL-LWADPQEANGMGPSQ
|||||...||.|||..|..  |......... . || ||||.||....||.|||| .. . .|.. |...|. . | .|....| |. ||.. .|...|.
GnhEsrqinkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsik.sldqikklerkievpeegklldlllssdpekeeglensk

RGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVVP
||.| .||||.|..||..|||. |.|.|||.. | .....||..|||||||||....|.| .... .
rGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailklee
subfamily_PPP1C_pd Subfamily PPP1C 209-471 9.2e-77 251.0 In-house 10-265 (282) alignment 
Range on Protein: 209-471
Range on HMM: 10-265/282.0
LPKKYVAAIISHADTLFRQEPSMVELENnstPdvkISVCGDTHGQFYDVLNLFRKFGkVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNR
| .. . |....| ... ..| ..|||.   |   . ..|| |||..|.|.|| . | . |...||| ||.||||. | |. .|. ..|| .|.|.|| |
lkeaeieallkkareillsqpillelea...P...vkivgdihGqyadllrlfetsg.aPpesnylflGdyvdrGkqsletivlllaykikypenlfllr

GNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDpSATLSDFKNIDRFAQPPRDGAFMELLWADPQE-ANGMGPSQR
||||| ..|.|||| |||| .||......| . |. ||||.|...  |..|||| ..    |.. ..| |  . |..|  ..|||.||..  .|.. ..|
GnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspe.lksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
|  ..||.|. ..||..|.|  | |.|..   | .| .| .|.|||||||||.. .| |.|..|
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 209-471 5.6e-52 169.9 In-house 3-260 (284) alignment 
Range on Protein: 209-471
Range on HMM: 3-260/284.0
LPKKYVAAIISHADTLFRQEPSMVELenNSTpdvkISVCGDTHGQFYDVLNLFRKFGkVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNR
.| . | ... || ..| ..| ..|   ||     | .||| |||| |.| || | | .  .  ||| ||.||||    |  ||... |.. || ||. |
ippedvetllfhafsifnkqpmliev..nsp....inicgdihgqfsdllrlfdkng.fphranylflgdyvdrgkhcletilllfaykvifpnhffmlr

GNHESDNMNKIYGFEDECKYKYSQ-RIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDR-FAQPPRDGAFMELLWADPQE-ANGMGPS
||||   .|||||| .||. .| .  ..  |   |  .||..|. .  |.||||. |     .|... | | | .|  .   ...||.|| .  .|  | 
gnhecslinkiygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggv.skmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpn

QRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
 ||. . || |   ..|   ..  . |.|..   | .|  . .|.|.|||| ||    |   |..|
srgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyv
PP2Ac_SM00156 210-493 8.9e-101 329.5 In-house 2-267 (271) alignment 
Range on Protein: 210-493
Range on HMM: 2-267/271.0
PKKYVAAIISHADTLFRQEPSMVELEnnstpdVKISVCGDTHGQFYDVLNLFRKFGkVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRG
 |..|............||...||..       .. |.||.|||..|.|.|... | . |...|.|.||.||||..|.|| ||...||||.|....|.||
skeevlelleevkeilkqeknlvevs......apvtvvGdihGqlddllrllelag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRG

NHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSdPSATLSDFKNIDRFAQPPRDGAFMELLWADP-QEANGMGPSQRG
||||...|||||||.|.|.||...|...| . |..||||.|.....|.|||||..  . .|.|.....|....|..| ...|||.|| |. .|. ||.||
nHEsssvnkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlsp.eleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrg

LGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVvpghgilqagrNDDQNLIIETF
|.. ||.|....||..|.|. |.|.||. . | .|....||.|.||||||||...|.. |..|           .....| ||..
lsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkv...........eknlklsieql
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 211-471 4.4e-59 193.0 In-house 10-263 (281) alignment 
Range on Protein: 211-471
Range on HMM: 10-263/281.0
KKYVAAIISHADTLFRQEPSMVELENnstPdvkISVCGDTHGQFYDVLNLFRKFGKVgPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGN
|. . ..| .....| .| ..||...   |   | | || |.|| |. .||   |.| |.. ..| ||.||||  | || .|...||| .... .| |||
keeienvireveaifseekaLveidk...P...ivvvGdlhaqfndlkrlfellgrv.peevlvflgdyvdrgpqslevlillftlkiryrdrivllrgn

HESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQE-ANGMGPSQRGL
||  ..||||||  ||..|| . ..  | . |. ||...||..  |.||||| |    .| . .|. .  ...  |  ..||||||.. ...   | || 
heiasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGl.sPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGs

GHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
.. || .. |   .. ..  | |.| . . |..  .  ||.||||.||||.   | . |. |
sftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkv
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 211-477 1.4e-46 152.0 In-house 22-284 (307) alignment 
Range on Protein: 211-477
Range on HMM: 22-284/307.0
KKYVAAIISHADTLFRQEPSMVELENnstPdvkISVCGDTHGQFYDVLNLFRKFGKvGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGN
|. .  .|  |.|.|  | ..|...    |     | || |||| |..|.|  .|.  |.  |.| ||.||||  | |. ||... || .|.|  | |||
keefenviyeaqtifssekalvdidp...p...cvvvgdlhgqfndlinmfillgr.ppetvyvftgdyvdrgllslecilllftykicypenivllrgn

HESDNMNKIYGFEDECK---YKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQEA-NGMGPSQ
||   .|| ||| .||     |  . |. .| . |. ||...||    |.||||| |   . | ...|  .  . |  |   ..|||||. .      | 
heiarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhggl.spaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkass

RGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVVPGHGI
|| | .|| .. |   .   .  | |.|.. . |       ||.|.|||| ||.   | | |..|    ||
rgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgi
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 211-471 6.8e-36 117.0 In-house 8-286 (302) alignment 
Range on Protein: 211-471
Range on HMM: 8-286/302.0
KKYVAAIISHADTLFRQEPSMVELennSTPdvkISVCGDTHGQFYDVLNLFRK-F---------GKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILH
|. . ..|..   |...| ...|.   |.|   ... || |||| |.. .. .                .. ..| ||.||||| | |   | ..||.|.
ksellllieaviellkkektlaei...spP...vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvly

PNNFFLNRGNHESDNMNKIYGFEDECKYKYS----QRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPP-RDGAFMELLWAD
|.|. | |||||.  .|  |||..| . ...    ..|.. | . |  .|||.|. .  | .|||. |.   .| | |.|.|  .    |    .||.||
ptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdllfad

PQEANGMG-----P-----SQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
| .....      |       ||| . |       . ..  |. | |.|     | .|  . ||.|.||||.| .   | | |..|
pldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 211-471 8.3e-36 116.7 In-house 9-287 (302) alignment 
Range on Protein: 211-471
Range on HMM: 9-287/302.0
KKYVAAIISHADTLFRQEPSMVELennSTPdvkISVCGDTHGQFYDVLNLFRK-F---------GKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILH
|. . ..|..   |...| ...|.   |.|   ... || |||| |.. .. .                .. ..| ||.||||| | |   | ..||.|.
ksellllieaviellkkektlaei...spP...vtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvly

PNNFFLNRGNHESDNMNKIYGFEDECKYKYS----QRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPP-RDGAFMELLWAD
|.|. | |||||.  .|  |||..| . ...    ..|.. | . |  .|||.|. .  | .|||. |.   .| | |.|.|  .    |    .||.||
ptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggi.spklesledikkikrplkevtedslaqdllfad

PQEANGMG-----P-----SQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
| .....      |       ||| . |       . .. .|. | |.|     | .|  . ||.|.||||.| . . | | |..|
pldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkv
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 212-472 3.3e-54 176.9 In-house 19-276 (290) alignment 
Range on Protein: 212-472
Range on HMM: 19-276/290.0
KYVAAIISHADTLFRQEPSMVELENnstPdvkISVCGDTHGQFYDVLNLFRKFGKvGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNH
| .  |. ... ...  |...|.|.   |   | . || |||. ..|. | . |.  ||  .|| ||.||||. | ||.||..|.||.....  | ||||
kdileilekieeileplpallevea...p...ivivgdihgqldallryfdavgy.ppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnh

ESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQP--PRDGAFMELLWADPQE--ANGMG-PSQ
|  ..|..||| .|   | . |..... . |. |.| . ...  | ||||. |.   .   .| . .   |    .|  ..||||||..  .. .    |
evrkvnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggi.sqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkq

RGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVV
|..   || .  | .|..  |  | |.||..  | .|. . ||.|||||| |.  . ||| ...| 
raisvvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvs
subfamily_PPZ_pd Subfamily PPZ 212-474 4.9e-54 176.8 In-house 28-283 (300) alignment 
Range on Protein: 212-474
Range on HMM: 28-283/300.0
KYVAAIISHADTLFRQEPSMVELennsTPDVKIsvCGDTHGQFYDVLNLFRKFGkVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNH
. .  |  .|  ||  .|...||    .| |||   || |||. |.| || | | . |.  ||| ||.||||  | |  ||..| || .|.|||| ||||
seilqicikarelflaqpallel....spsvki..vgdvhgqyadllrlftkcg.fppsanylflgdyvdrgkqsletillllcykikypenffllrgnh

ESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQE-ANGMGPSQRGLG
|  |. ..||| |||| .   .|.. | ..|..||||...    ...|||| |    .. . . . | .. |  |   .|||.|| . .|     .||. 
ecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhggl.spvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvs

HAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVVPG
...     ..|| .  .  . |.| .   | .| .   |.|||||||||    | | |. |  |
ycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvseg
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 212-464 6.1e-54 176.3 In-house 26-274 (297) alignment 
Range on Protein: 212-464
Range on HMM: 26-274/297.0
KYVAAIISHADTLFRQEPSMVELENnstPdvkISVCGDTHGQFYDVLNLFRKfGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNH
. |  ..  |  .|... ||||..    |   | |||| |||| |.| ||.. |   |   ||| ||.|||| .| |  .|. . |.  | |.|| ||||
ervlklldlaldvfkaqksmvevna...p...ikvcgdihgqfpdllrlfhr.ggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESDNMNKIYGFEDECKYKY-SQRIFNMFAQSFESLPLATLINNDYLVMHGGLPS--DPSATLSDFKNIDRFAQpPRDGAFMELLWADPQE-ANGMGPSQR
| . .||.||| .||. .| | |..  | . |. |||. || .  |.|||||        ||  ...|.|  .  ...   .||||||     |.   ||
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfmenqr

GLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGN
| |  || |   .   . ||  . |.|..   | .|    ||.|.|||| ||    |
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdn
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 213-471 3.6e-60 196.3 In-house 14-268 (287) alignment 
Range on Protein: 213-471
Range on HMM: 14-268/287.0
YVAAIISHADTLFRQEPSMVELENnstPdvkISVCGDTHGQFYDVLNLFRKFGKvGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHE
 .  .. ... ...  |...|.|.   |   |...||.|||. |.|..| . |.  ||  ||| ||.||||. | ||.||...|||. |..  | |||||
dilevlekieeileplpallevea...p...itivGdihGqlddllrifnavGa.apkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhe

SDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPPR--DGAFMELLWADPQ-EANGMGPS-QRG
  ..||.|||..| | |...|... | . |. ||| . ...  | ||||. |.   .| ..| . .  .|    .|  ..||||||. .|... .  .|.
vkkinklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGi.spklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkira

LGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
.   ||    | .|.. ..  | |.||..  | .|. . .|.|||||| |.  . ||| |..|
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvv
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 214-471 8e-61 198.6 In-house 11-261 (280) alignment 
Range on Protein: 214-471
Range on HMM: 11-261/280.0
VAAIISHADTLFRQEPSMVELENnstPdvkISVCGDTHGQFYDVLNLFRKFgKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHES
. ..| .   ..  . .|||..    |   ..|||| |||. |.| || .     | . ||| ||.||||.   || ||  . |. .||||.. ||||| 
idrviekckkiltaqatmvevda...p...vavcgdlhgqytdllrlfarv.sfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhev

DNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQ-EANGMGPSQRGLGHA
 ..|. ||| ||.| .||. ..| | . ..||||..|..   |.||||| |.   .|.|.... |  ... .   |.||||||. .  | . ..||  . 
isinrkygfkdevkrryslalynefqelldslplvalvsgrilcmhggl.sqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvi

FGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
|| ..   . .  ..  | | |..   | .|  . ||.||||||.|...  |  .|. |
fganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavliv
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 214-469 1.7e-49 161.8 In-house 11-259 (280) alignment 
Range on Protein: 214-469
Range on HMM: 11-259/280.0
VAAIISHADTLFRQEPSMVELEnnstpdVKISVCGDTHGQFYDVLNLFRKFGKVgPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHES
. |||   ...| .|  ..| |        | | || | |. |.  ||   |.| |.   .| ||.||||    || .|..|||| . .  .| |||||.
iiaiirmveaifmeesnlceae......apikvigdihaqyqdmnrlfdligrv.peeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhet

DNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDpSATLSDFKNIDRFAQPPRDGAFMELLWADPQE-ANGMGPSQRGLGHA
 ..||||||  ||.|||   ..  |   |. .|.. ||..  |.|||||  .    |   .|| | ..|   | ...|||.|| . ..|   | ||. . 
psvnkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspe.linldtirniprpcepldrgllidllwsdptnkgegwfhsirgisym

FGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVI
||  . ..  .. ..  | |.|..   | ..    .|.|||| ||||    |   |.
fgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavv
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 216-469 1.3e-56 185.1 In-house 31-278 (299) alignment 
Range on Protein: 216-469
Range on HMM: 31-278/299.0
AIISHADTLFRQEPSMVELENnstPdvkISVCGDTHGQFYDVLNLFRKFgKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDN
 . . | . | ...|..|.|.   |   | |||| |||. |.| .| |  .  |.  .|| ||.||||    |.  |..| || .|..||. |||||   
tlcavaksvfasqasllevea...p...iivcgdihgqysdllrifdka.gfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpa

MNKIYGFEDECKYKY-SQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPPRDGAFMELLWADPQE-ANGMGPSQRGLGHAF
.|..||| .||. .| | |.. .| ..|. .||. ||..  |.||||| |    ||  .... |  .||     ..||||||..   .  .  ||. . |
inrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhggl.spklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlanvrgvsyvf

GPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVI
|.|.    . . ..  . |.|..   | .|  . ||.|.|||| ||    |   ..
gqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaim
subfamily_PPPLV_pd Subfamily PPPLV 218-462 3.7e-42 137.6 In-house 6-267 (290) alignment 
Range on Protein: 218-462
Range on HMM: 6-267/290.0
ISHADTLFRQEPSMVELENNstpdvkISVCGDTHGQFYDVLNLFRKFGKVGPKH---TYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESD
 . |   . .|  ..||.        . | || ||.. |.  . ... ..|..    ..|| ||.|||| .| |.   .. ||.| |  ..| ||||| .
cdvavdilaaeerllelksp......tyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhele

NMNKIYGFEDECKYKYSQR---IFNMFAQSFESLPLATLINNDYLVMHGGLPS--DPSATLSDFKNIDRFAQPPRDGAF--MELLWADPQEAN-------
 . . . .  |...|. ..   ... | . |. ||||. |..  . .|.|.|     .| .|  ..|    . . |||   ...||.||.| .       
svqesieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrge

-----GMG-PSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQ
     |.   ..|| || |. |  ..||..| |  . |.|| .  |... |||.|.||||. .|| | 
lvlneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGss
PPP_1 221-470 1.5e-91 299.4 In-house 7-263 (264) alignment 
Range on Protein: 221-470
Range on HMM: 7-263/264.0
ADTLFRQEPSMVELENNSTPDVKISVCGDTHGQFYDVlNLFRKFGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIY
|... ...  ... ||... . .|.||||.||||.|. . ..|.|.  |...|||.||.||||..|.|. ||...||. .|...||.||||||....|.|
aelkkklkellnkeenllevseeitvcGDiHGqfdDL.lklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtkvy

GFEDECK-YKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPSATLsDFKNIDRFAQPPRDGAFMEL--------LWADPQEANGMGPSQRGLGH
||..|.. .|||..|.......|. ||||.||....|..|||| .. .... . ....|. . | .|....|        |..|.......  |.|| |.
gFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlld.qirkerrktevpeegklcdllekdvdillsddkeqeeavansiRGagy

AFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIH
.||.|.|..||..|.|. |.|.||... | .| .|.|..|.|||.||.....|.| ...
lfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_PPP4C_pd Subfamily PPP4C 232-470 2e-68 223.7 In-house 33-270 (288) alignment 
Range on Protein: 232-470
Range on HMM: 33-270/288.0
VELENNSTPDVKISVCGDTHGQFYDVLNLFRKFGKVgPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKY-
||  |  . |  . |||| ||||||.|.||.  |.| |.. ||| ||||||| .| |  ||. .||. .|..  | |||||| .. ..||| |||  || 
veesnvqrvdspvtvcgdihgqfydllelfkvggdv.petnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqitqvygfydeclrkyg

SQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDpSATLSDFKNIDRFAQPPRDGAFMELLWADPQEANGMGPSQRGLGHAFGPDITDRFLRNNKLRKI
|...... .. |. |.||..|... ...||||  .  .|| . . |||  . |..|.. .|||.||..|.| . | || |. || |....| ..|..  |
sanvwryctevfdylslaaiidgkifcvhgglsps.istldeirsidrkqevphegplcdllwsdpedaegwavsprgagylfgsdvveqfneandieli

FRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIH
 |.|.| | | ..  . |..||.||||||   ||.  ...
crahqlvmegyklhfnekvltvwsapnycyrcgnvaaile
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 241-471 1.1e-59 195.2 In-house 34-269 (284) alignment 
Range on Protein: 241-471
Range on HMM: 34-269/284.0
DVKISVCGDTHGQFYDVLNLFRKFGKV-----GPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIF
.. . ..|| |||| |.| |.   |         .. ||| ||.|||| .| || .|....|.|.|.. || ||||||  .|. |||  ||| .||....
eapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpvnmqygfyleckkrysealy

NMFAQSFESLPLATLINNDYLVMHGGLPSDpSATLSDFKNIDRFAQPPRDGAFMELLWADPQE-ANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSH
..|  .|...||......  . ||||.. |    | ......|  . |  |   .| ||||..  .|.  |.|| |. ||..  ..||.. ||  . |.|
eafqlafnamplcavvskkiicmhggised.lldlkqldklerpidipdigviadltwadpeaevegykesprgagkvfgakavkeflkkfkldlvvrah

ELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHV
.. | | .|    ||.|.|||| ||    |.. |..|
qvvmdgyeffadrklvtifsapsycgqldniaavlnv
subfamily_YNL217W_pd Subfamily YNL217W 241-348 8.3e-07 21.7 In-house 9-121 (235) alignment 
Range on Protein: 241-348
Range on HMM: 9-121/235.0
DVKISVCGDTHGQFYDVLNLFR-KFGKVGPKHTYLFNGDFVDRGSWSCEVALLFyclkilHPNNFFLNRGNHESDNMNKI------YGFEDE---CKYKY
  .. | || || . ....|.  | |  ..  . .. ||....|  | ||  .       . ..    .||||   . ..       |.|.     |...
gkrllvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsf

S-QRIFNMFAQSFESLPLA
  ... .   .   .|. .
lesklskadmeyarelgfs
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 243-469 7.2e-39 127.0 In-house 8-240 (263) alignment 
Range on Protein: 243-469
Range on HMM: 8-240/263.0
KISVCGDTHGQFYDVLNLFRKFGKVgPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQ-----RIFNM
 | .|||||||. |.| .|   |    |  ||| ||.||||  | || .|.. ||.  | ...| |||||   .|| |||  | | .. .      ..| 
pinicgdthgqyndllrifnacgaa.tktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyesvynh

FAQSFESLPLATLINNDYLVMHGGLpSDPSATLSDFKNIDRFAQPPRD-GAFMELLWADPQ-EANGMGPSQ-RGLGHAFGPDITDRFLRNNKLRKIFRSH
| | |  .||......  |.||||. |    .| | . |    .  .      .||||||. .|.|. | . | .   ||    | . .   .  | |.|
fnqvfsymplcaivskrilcmhggi.sphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidlivrah

ELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVI
..   |  |    .|.|||||  |     |   |.
qvveygyaffadrrlitvfsasryqielcnyaavv
Metallophos Calcineurin-like phosphoesterase 243-435 2.7e-38 125.3 Pfam-A 2-197 (200) alignment 
Range on Protein: 243-435
Range on HMM: 2-197/200.0
KISVCGDTHGQFYDV---LNLFRKFGKVGPKHTYLFNGDFVDRGSWSCEVALLF--YCLKILHPNNFFLNRGNHESDNMNKIYGFEDECK----------
.| |.||.||...|    |... | .. ..  ..||.||.|||| || |.  |.  ..||.| |...||.|||||||..|. ||| .|.           
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------YKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDPSATLSDfknidrfaqpprdgafmellwadpqeangmg
                        ...  ... .. . |. |||..|.....|..||.| |..  ..                                 
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

psqrgLGHAFGPDITDRFLRNNKLRKIFRSHE
      .  |||| .. .|.....  ..|.|.
.....gselfgpdalekllekygvdlvlrGHt
PPP_2 244-436 3.1e-68 222.4 In-house 1-197 (198) alignment 
Range on Protein: 244-436
Range on HMM: 1-197/198.0
ISVCGDTHGQFYDVLNLFrKFGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECK-YKYSQRIFNMFAQSF
. ||||.|||..|.|.|| | |.  |...|||.||.||||..|.|| ||...||. .|....|.||||||...||.|||..|..  |......... . |
vtvcGDlHGqldDLlilf.knglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevf

ESLPLATLINNDYLVMHGGLPSDPSaTLSDFKNIDRFAQPPRDGAFMEL-----LWADPQEANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHEL
| ||||.||....||.|||| .. . .|.. |...|. . | .|....|     |. .... ... .|.|| | .||||.|...|..|||. |.|.||.
elLplaalidekvlvvHGGlseeik.lldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 244-436 4.1e-68 222.3 In-house 1-196 (197) alignment 
Range on Protein: 244-436
Range on HMM: 1-196/197.0
ISVCGDTHGQFYDV-LNLFRKFGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSF
. |.||.|||..|. |.|... |.  ... |.|.||.||||..|.|| ||...||.  |....|.|||||| ..|..|||..|.. |....|.... ..|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

ESLPLATLINNDYLVMHGGLPSDPSaTLSDFKNIDRFAQPP-RDGAFMEL-LWADPQ-EANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHEL
. ||||.||....||.||||... . .|.. ..|.|. . | .......| ||.||. . .|. .|.|| |..||||.|..||..|.|. | |||||
dllplaalidekvlvvhgglsdele.sldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 244-436 8.6e-65 211.4 In-house 1-198 (199) alignment 
Range on Protein: 244-436
Range on HMM: 1-198/199.0
ISVCGDTHGQFYDV-LNLFRKFGKVGPKHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYK-YSQRIFNMFAQS
. ||||.|||..|. | ||.. |.  ... |.|.||.||||..|.|| || ..||.. |....|.|||||. ..|.||||..|.. | ....|.... ..
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FESLPLATLINNDYLVMHGGLPSDPSaTLSDFKNIDRFAQPP-RDGAFMEL-LWADPQ-EANG-MGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHEL
|. ||||.||....||.||||...   .... ..|.|. . |  .|  ..| ||.||. . .| . .|.|| |..||||.|..||..|.| .| |||||
fdwlPlaalidekvlvvhgglspeik.siellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 270-471 2e-56 184.5 In-house 100-301 (317) alignment 
Range on Protein: 270-471
Range on HMM: 100-301/317.0
KHTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLPSDpSAT
.. ||| ||.|||| .| || .|...||.|.|.. || |||||| ..|. |||  |.|..||......| . |. |||....|.  | ||||.. .    
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGisee.lld

LSDFKNIDRFAQPPRDGAFMELLWADPQE-ANGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGV
|. .....|  . |  |   .| ||||..  .|  .|.|| |. ||..  ..||.. .|  . |.|.. . | .| .  ||.|.||||.||  . |.. |
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

IHV
..|
lsv
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 271-469 4.7e-44 143.9 In-house 120-318 (339) alignment 
Range on Protein: 271-469
Range on HMM: 120-318/339.0
HTYLFNGDFVDRGSWSCEVALLFYCLKILHPNNFFLNRGNHESDNMNKIYGFEDECKYKYSQRIFNMFAQSFESLPLATLINNDYLVMHGGLpSDPSATL
. ||| ||.|||| .| || .|. .||. .|.  .| ||||||  .|  |||  | .|.|  .... | . |. .|....|||  ..||||. |.  ...
krylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggi.sehltsf

SDFKNIDRFAQPPRDGAFMELLWADPQEA-NGMGPSQRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVI
 .|  . |  . |  | . .| ||||. . .|  || ||    |||     ||..  |. . | |..   | .| .  .|.|.|||||||  . |   |.
nqfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavf
subfamily_PPP7C_pd Subfamily PPP7C 389-472 3.4e-19 61.8 In-house 238-322 (383) alignment 
Range on Protein: 389-472
Range on HMM: 238-322/383.0
MELLWADPQEANGMGPS-QRGLGHAFGPDITDRFLRNNKLRKIFRSHELRMGGVQFEQKGKLMTVFSAPNYCDSQGNLGGVIHVV
...||.||.. .|  |   || |  ||||.|...|.. .|. . |||| .. | .|  . |..|.||| || .   | |  ... 
ldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklg