Gene PFK26 in Saccharomyces cerevisiae

Synonym: YIL107C, PFK26

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP034_AA protein Get Run
ScerP034_AA_392-634 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 174-395 1.3e-89 289.4 Pfam-A 4-222 (223) alignment
Range on Protein: 174-395
Range on HMM: 4-222/223.0
LISKEDSGSKLVIVMVGLPATGKSFITNKLSRFLNYSLYYCKVFNVGNTRRKFAKEhglkDQDSKFFEPKNADSTRLRDKWAMDTLDELLDYLLEGSGSV
 ..|... ||||||.|||||.||..|..||.|.|... ...||||||..||...|.    ..|..||.|.|.....||.|.|...|..||.|| |..|.|
stvknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavka....lsdaeffrpdneealklreklalaalkdllkylneeegqv

GIFDATNTSRERRKNVLARIRKRSphLKVLFLESVCSDHALVQKNIRLKLFG-PDYKGKDPESSLKDFKSRLANYLKAYEPIE--DDENLQYIKMIDVGK
.|||||||.|||||..|.......  ||||||||||||......||... .. ||||.|..|...|||..||.|| |.|||..  .||.|.|||.|||||
aifDAtNttrerRklilefveenn..lkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgk

KVIAYNIQGFLASQTVYYLLNFNLA
.....|.||.|.|..||||||..|.
slvvnnvqgylqsrivyyllNihlk

AAA_33 AAA domain 185-344 1.4e-11 35.0 Pfam-A 1-140 (143) alignment
Range on Protein: 185-344
Range on HMM: 1-140/143.0
VIVMVGLPATGKSFITNKLSRFLNyslyyCKVFNVGNTRRKFAKehglKDQDSKFfepknaDSTRLRDKwAMDTLDELLDYLLEGSGSVgIFDATNTSRE
....||||..|||.  ..| . |      . . .  . ||. ..    .||.|.       |.||.... . ..| .|.   |.  .|| |.||||.|||
lvllvGlpGsGKstlaerllkklg.....yvrlsqdtlrrrlfg....tdqqslt......dytrvlkr.lyqilnklarkalsagrsv.ivdatnlsre

RRKNVLARIRKRSPHLKVLFLEsvcSDHALVQKNIRLKLFGPDYKGKDPESSLKDFKSRL
.|. ...  .. .   ....||    . .. ..... .    |.. . ||. |.... |.
erarfvklakrlgvpvrivyle...vpeetlaeRlakRerngddrsevpeealdrmlarf

AAA_17 AAA domain 185-282 4.2e-09 27.9 Pfam-A 1-78 (121) alignment
Range on Protein: 185-282
Range on HMM: 1-78/121.0
VIVMVGLPATGKSFITNKLSRFLNYSLYYCKV-FnvgntrrkfaKEHGLKDQDSKFFEPKNADSTRLRDKwaMDTL---DELLDYLLEGsgsvgifdatn
||. .| |..|||.....|.. |..  ...   .          .| |||  | ...| |.||  .|..   .| |   .. |.....|           
viaitGppGsGKsTlakeLaerlglpvlslddll..........reeglkelddgereskdadadllaai..ldglaakkdtlswvidg...........

tS
 .
.a

AAA_18 AAA domain 186-285 9.2e-06 15.0 Pfam-A 1-87 (129) alignment
Range on Protein: 186-285
Range on HMM: 1-87/129.0
IVMVGLPATGKSFITNKLSRFLnyslyyckvfnvGNTRRKFAKEHGLKDQDSKFfePKNADSTRLRDKWAMDTLDELLDYLL-EGSGSVGIFDATNTSRE
|. .| |..||. ....|.. |            |   |..|||.|| . . ..   ....| .|. .  .  ||.| ..   .. |.. |.| . .  |
IlitGtpGsGKtTlakeLaerl............gdvlrdlakeegleeevddk..idtkeskeldedkldelldkleeneselaegenviidghlaele

R
.
l

subfamily_PFKFB_pd Subfamily PFKFB 391-612 1.3e-79 258.3 In-house 1-196 (198) alignment
Range on Protein: 391-612
Range on HMM: 1-196/198.0
NFNLADRQIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARqreifyqnlmqqkknnentdGNIYnDFFVWTSMRARTIGTAQYFnedDYPIK
|  |..|.|...|.||||.|..|||||.|.||.|| ..||.| |||..                     |.. .. ||||...||| ||...   ..| .
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfike....................enlk.elrvwtselkrtiqTaell...glpke

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELERIEDNVLIITHRVVARALLGYFMNLSMGIIANLDVP
|.|.||||.||..||.|| |||..|||||..|.|||.|||||  .||||.|...||.|||.||||...|||||.|. |.|.||.|....|.  ...|.||
qwkaLdeldaGkcdgltyeeikekfpeefkerkkdkyryryp..rgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvp

LHCVYCLEPKPYGITWSLWEYD
||.|..|.|..||....|...|
lhtvikltpvaYgckvellkld

0037864 Phosphoglycerate mutase-like 393-609 4.6e-39 126.3 In-house 4-207 (211) alignment
Range on Protein: 393-609
Range on HMM: 4-207/211.0
NLADRQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYQnlmqqkknnentdgniyndffVWTSMRARTIGTAQYF----NEDD
||. ......| ||.|.|. ||. |  ...||..| . |. | ...|..   | .                     |..|   |.| ||...    . . 
nllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfda.....................vysSpllRaiqTaeiilealglpl

YPIKQMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELERIE----DNVLIITHRVVARALLGYFMNLSMG
.|..... | |.. |...|.|..||.. .|||. ... |.. .|.|  ||||..||..|..|.. || .      .|||...|  | |||| |...||. 
lpvevdprlrErdfgalegltleeiaekypeelvawlrdpydfrpp..ggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsle

IIANLDVPLHCVYCLEPKPYGITWSLW
 . .| .| ..|..|| ...|... ..
ellrlnlpngsvtvlelddggwvlvsl

0036777 Phosphoglycerate mutase-like 397-613 6.1e-44 142.8 In-house 3-231 (247) alignment
Range on Protein: 397-613
Range on HMM: 3-231/247.0
RQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYqnlmqqkknnentdgniyndfFVWTSMRARTIGTAQYFNE----DDYPIK
......| ||.|.|..||. |  ...||..| . || | ......   |                      .|..|.  |.| ||... |    . .|..
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkelglpfd.....................avysSpllRAiqTaeiilealglsllpvv

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPG-----------------------IGGESYMDVINRLRPVITELERI----EDNVLII
... | |.. |...|.|..||.. .|||. ... |.. ||.|                         ||||..||..|..|...|| .     ..|||..
vdprLrErdyGalegltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvV

THRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLWEYDE
.|  | |||| |...||.. |..| .| .....|| ...| .|.|. ...
sHggvlrallayllglsledilrlnlpngsitvleldddgklwvleslnd

0053607 Phosphoglycerate mutase-like 397-609 9.7e-43 138.2 In-house 2-187 (191) alignment
Range on Protein: 397-609
Range on HMM: 2-187/191.0
RQIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARQREIFYQnlmqqkknnentdgniyndffVWTSMRARTIGTAQYFnedDYPIKQMKMLD
..... | ||.| |. ||. |...||..| . |. | ...|..   |                       |..|   |.. ||...   ..|..... | 
trlyLvRHGetewnaegrlqgdvpLtelGreqaralaellaelglkfda.....................vysSpllRarqTaeii...glpvevdprlr

ELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELERiEDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYC
|...||..|.|. |.....|||......|.| ||.|  ||||..||..|..|...|| . ..|||...|  | |||| |...|..  . .|..| ..|..
Eidfgdwegltleelaekypeelaawlrdpldyrpp..ggEsladvaaRvlpaleella.ggnvlvVaHggvirallayllglpleellrlnlpngsvtv

LEPKPYGITWSLW
||....|... |.
lelddggwvlvll

0051064 Phosphoglycerate mutase-like 397-613 2.7e-42 137.7 In-house 4-232 (241) alignment
Range on Protein: 397-613
Range on HMM: 4-232/241.0
RQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYqnlmqqkknnentdgniyndfFVWTSMRARTIGTAQ----YFNEDDYPIK
..... | ||||.|. ||. |  ...||..| . |. | ...|..   |                       |..|   |.| ||.    ... ...|..
krlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfd.....................avysSpllRaiqTaeiiaealglpllpvv

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPG-----------------------IGGESYMDVINRLRPVITELERI----EDNVLII
... | |.. |...|.|..||.. ||||. ..  |.| .|.|.                        ||||..||..|..|.. || .     ..|||..
vdprlrEidfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvV

THRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLWEYDE
.|  | ||||.|...|.   . .|..| ..|..|| ...| ...|. ...
sHggvirallayllglpleellrlnlpngsvtvleldddgkrvvlvllnd

0043909 Phosphoglycerate mutase-like 397-606 2.8e-41 133.9 In-house 3-228 (249) alignment
Range on Protein: 397-606
Range on HMM: 3-228/249.0
RQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYqnlmqqkknnentdgniyndfFVWTSMRARTIGTAQYFNE----DDYPIK
..... | ||.|.|. ||. |  .|.||..| . |. | .......  |                      .|..|   |.| ||... |    | .|..
krlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfd.....................avysSplkRAiqTaeiileelgldklpve

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQK-----------------------------DKLRYRYPGigGESYMDVINRLRPVITELERI----E
... | |.. |...|.|..||.. .|||. ...                              |.| .|.||  |||..||..|..|...|| .     .
vdprLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppg..gEsladvvaRvlpaleellarllkdg

DNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITW
.||||..|  | |||| |...||.  | .| .| .....||....|  .
gnvliVaHggvlrallayllglsledilrlnlpngsitvlelddggkpv

0049178 Phosphoglycerate mutase-like 397-609 3.3e-41 133.9 In-house 4-226 (243) alignment
Range on Protein: 397-609
Range on HMM: 4-226/243.0
RQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYqnlmqqkknnentdgniyndfFVWTSMRARTIGTAQYF----NEDDYPIK
..... | ||.| |. ||. |  .|.||..| . |. | ...|..   |                       |..|   |.| ||...    . . .|..
trlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellaelglkfd.....................avysSplkRaiqTaeiilealglpllpvv

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPG---------------------IGGESYMDVINRLRPVITELERI----EDNVLIITH
... | |.. |...|.|. ||. ..|||. ... |.. .|.|                       ||||..||..|..|.. || .     ...||...|
vdprLrErdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaH

RVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLW
  | |||| ....|... ...|..| ..|..|| ...|..   .
ggvirallalllglpleellrlnlpngsvtvlelddggwvlvsl

0036887 Phosphoglycerate mutase-like 397-609 1.6e-40 131.2 In-house 2-195 (202) alignment
Range on Protein: 397-609
Range on HMM: 2-195/202.0
RQIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQreifyqnlmqqkknnentdgniyNDFFVWTSMRARTIGTAQYFNED-DYPIKQMK
......| ||.|.|| ||. |  ...||..| . |. | ...|                         . . |..|   |.| ||... |  ..|.....
trlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerlagl.......................pfdavysSpllRaiqTaeiiaealglpvivdp

MLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELERI--EDNVLIITHRVVARALLGYFMNLSMGIIANLD-VP
 | |.. |...|.|..||.. .|||. ... |.. .|.|  ||||..||..|......|| .   ..|||...|  | |||| |...||.  . .|. .|
rlrEidfgalegltleeiaekypeelaawlrdpydfrpp..ggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklp

LHCVYCLEPKPYGITWSLW
 ..|..|| ...|... |.
ngsvtvlelddggwvlvll

0039931 Phosphoglycerate mutase-like 398-634 2.6e-50 163.1 In-house 1-210 (219) alignment
Range on Protein: 398-634
Range on HMM: 1-210/219.0
QIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARQREIFyqnlmqqkknnentdgniyndFFVWTSMRARTIGTAQYFnedDYPIKQMKMLDE
.....| ||.|.|| ||. |.|.||.|| . |. | .......  |                     . |..|   |.| ||...   ..|..... | |
rlyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpf.....................davysSpllRaiqTaeii...glpveidprLrE

LSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPGigGESYMDVINRLRPVITELERiEDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYCL
...||..|.|..||....|||......|...||.||  |||..||..|..|...||.. ..|||...|  | |||| |...||.  |..|..| ..|..|
idfgdlegltleeiaekypeelaawlrdpydyrppg..gEsladvvaRvlpaleella.genvlvVsHggvirallayllglsleeilrlnlpngsvtvl

EPKPYGITWSLWEYDEASDSFSKVPQTDLNTTRVKEV
|....|... |. . .  |.. ... ..|...... .
elddggwvlvllnltshlddllrlllltlelllllll

0035570 Phosphoglycerate mutase-like 398-630 7.3e-50 161.7 In-house 1-206 (219) alignment
Range on Protein: 398-630
Range on HMM: 1-206/219.0
QIWITRSGESEDNVSGRIGGNSHLTPRGLRFAKSLPKFIARQReifyqnlmqqkknnentdgniYNDFFVWTSMRARTIGTAQYFnedDYPIKQMKMLDE
.....| ||.|.|..||. |...||.|| . |. | ...|...                     .. ..|..|   |.| ||...   ..|..... | |
rlyLvRHGetewnlegrlqgdvpLterGreqaralgealadlg.....................ipfdavysSpllRaiqTaeii...glpveidprLrE

LSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELERiEDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVYCL
...||..|.|..||.. .|||. ... |...||.|  ||||..||..|..|...|||. ..|||...|  | |||| |...|... |..|..| ..|..|
idfgdlegltldeiaekypeelaawlrdpydyrpp..ggEsladvvaRvlpaleeled.genvlvVsHggvirallayllglpleeilrlnlpngsvtvl

EPKPYGITWSLWEYDEASDSFSKVPQTDLNTTR
|....|..|.|. ... |    ..... |....
eldggggkwvlvllndtshlelllellllslll

0048955 Phosphoglycerate mutase-like 398-612 3.4e-41 134.0 In-house 2-228 (240) alignment
Range on Protein: 398-612
Range on HMM: 2-228/240.0
QIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIARQREIFYqnlmqqkknnentdgniyndfFVWTSMRARTIGTAQYF----NEDDYPIKQ
.... | ||||.|. ||. |  ...||..| . |. | ...|..   |                       |..|   |.| ||...    . . .|. .
rlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfd.....................lvysSpllRaiqTaeiiaealglpllpvvv

MKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPG-----------------------IGGESYMDVINRLRPVITELER----IEDNVLIIT
.  | |.. |...|.|..||...||||....  |.| .|.|.                        ||||..||..|..... || .     ..|||...
dprlrErdfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVs

HRVVARALLGYFMNLSMGIIANLDVPLHCVYCLEPKPYGITWSLWEYD
|  | ||||.|...|.   |..|..| ..|..|| .... ... ... 
Hggvirallayllglpleeilrlnipngsvtvlelddglvslndtshl

0050036 Phosphoglycerate mutase-like 398-599 3.5e-33 106.6 In-house 2-167 (171) alignment
Range on Protein: 398-599
Range on HMM: 2-167/171.0
QIWITRSGESEDNVSGRIGG--NSHLTPRGLRFAKSLPKFIarqreifyqnlmqqkknnentdgniyNDFFVWTSMRARTIGTAQYFNeddYPIKQMKML
.... | ||.| |. ||. |  .. ||..|.. |. | ...                          .  .|..|.  |.. ||...    .|. ... |
rlyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell..........................pfdavysSpllRArqTaelil...lpvivdprL

DELSAGDYDGMTYPEIKNNFPEefekrqKDKLRYRYPGIGGESYMDVINRLRPVITELErieDNVLIITHRVVARALLGYFMNLSMGIIANLDVPLHCVY
 |.. |...|.|. ||.. .||       ..  ....  ||||..||..|..|.. ||    .|||...|  | |||| ....||.  | .|..| ..|.
rErdfGawegltldeiaakype......wlldlldlappggEsladvlaRvlpaleell...gnvlvvaHggvirallalllglsleeilrlelpngsvl

CLEP
.|| 
vlel

His_Phos_1 Histidine phosphatase superfamily (branch 1) 398-572 1.1e-30 99.7 Pfam-A 1-158 (158) alignment
Range on Protein: 398-572
Range on HMM: 1-158/158.0
QIWITRSGESEDNVSGRIGGNSH--LTPRGLRFAKSLPKFIARqreifyqnlmqqkknnenT----DGniyndffVWTSMRARTIGTAQYFNE-DDYPIK
.....| |||| | .||. |.|.  ||..| . |..| | ..|                       |        |.||   |.| ||....|  |.||.
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr..................adlpida.......vytSplkRaiqTaeilleeldipii

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELE---RIEDNVLIITHRVVARAL
. . | |...|...|....|.|..||||.||...|| ..|.|  .|||. ||..|..|...||    . ..||||..|. | |||
keprLrerdfgeweglpkeevkeefpeeyekwkrdkkefrpp..egesladvyeRvapfleelieakdkgenvlivsHggvlral

His_Phos_1 Histidine phosphatase superfamily (branch 1) 398-572 1.1e-30 99.7 In-house 1-158 (158) alignment
Range on Protein: 398-572
Range on HMM: 1-158/158.0
QIWITRSGESEDNVSGRIGGNSH--LTPRGLRFAKSLPKFIARqreifyqnlmqqkknnenT----DGniyndffVWTSMRARTIGTAQYFNE-DDYPIK
.....| |||| | .||. |.|.  ||..| . |..| | ..|                       |        |.||   |.| ||....|  |.||.
rlylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkr..................adlpida.......vytSplkRaiqTaeilleeldipii

QMKMLDELSAGDYDGMTYPEIKNNFPEEFEKRQKDKLRYRYPgiGGESYMDVINRLRPVITELE---RIEDNVLIITHRVVARAL
. . | |...|...|....|.|..||||.||...|| ..|.|  .|||. ||..|..|...||    . ..||||..|. | |||
keprLrerdfgeweglpkeevkeefpeeyekwkrdkkefrpp..egesladvyeRvapfleelieakdkgenvlivsHggvlral