Gene CYR1 in Saccharomyces cerevisiae

Synonym: CDC35, FIL1, HSR1, SRA4, TSM0185, YJL005W, CYR1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPM
Superfamily PPM
Family PPM
Subfamily PPM-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP037_AA protein Get Run
ScerP037_AA_1337-1624 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Ad_cyc_g-alpha Adenylate cyclase G-alpha binding domain 368-418 4.5e-16 44.5 Pfam-A 2-50 (52) alignment
Range on Protein: 368-418
Range on HMM: 2-50/52.0
EATTPTIETpisCKPSLFRLDTNLEDVTDI-TKTVPPTAVNSTLNSTHGTET
|..||| |.   ...|.|.|||||.|...| ||. |.|...|.|......|.
etitptdee...eegsvfsLDTNLsdMeGIltkpePltPtdsslindgesek

RA Ras association (RalGDS/AF-6) domain 677-744 6.4e-13 36.6 Pfam-A 2-76 (93) alignment
Range on Protein: 677-744
Range on HMM: 2-76/93.0
HYAIRIFNTDDT----FTTLSCTPATTVEEIIPALKRKFNI-TAQGNFQI--SLKVGKLSKILRPTSKPILIERK
.. .|.. .|..    ..|..... ||..|.| || .||.. . ......  ||. |.  ..| .. ||  | ..
sgvlrVytedgkpgttyktilvsstttaqeVieallekfgledspedyaLveslerggeervLsddekplqiqlq

LRR_4 Leucine Rich repeats (2 copies) 864-903 1.9e-08 23.7 Pfam-A 2-41 (44) alignment
Range on Protein: 864-903
Range on HMM: 2-41/44.0
KLVSLELQRNFIRKVPNSIMKLSNLTILNLQCNELESLPA
.| .| |..| | ..|... .|.||. |||. | ...|.|
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa

LRR_8 Leucine rich repeat 865-921 1.8e-12 36.5 Pfam-A 3-61 (61) alignment
Range on Protein: 865-921
Range on HMM: 3-61/61.0
LVSLELQRNFIRKVPN-SIMKLSNLTILNLQCNELESLPA-GFVELKNLQLLDLSSNKF
| .| |..| ....|. |  .||||. |.|..|.|.|...  |  |..|. |.||.|..
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl

LRR_4 Leucine Rich repeats (2 copies) 909-949 6.2e-08 22.0 Pfam-A 1-41 (44) alignment
Range on Protein: 909-949
Range on HMM: 1-41/44.0
KNLQLLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQ
.||. ||||.|.    |...  ..|| ...||.|.|..|..
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa

LRR_8 Leucine rich repeat 933-989 6.3e-10 28.3 Pfam-A 2-61 (61) alignment
Range on Protein: 933-989
Range on HMM: 2-61/61.0
NLLQIDLSYNKIQSLPQ-STKYLVKLAKMNLSHNKLNFIGD--LSEMTDLRTLNLRYNRI
||  .||| |.....|. | |.| .| ...||.|.|. | .  .. .. || |||..||.
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl

LRR_4 Leucine Rich repeats (2 copies) 957-993 5.9e-09 25.3 Pfam-A 3-40 (44) alignment
Range on Protein: 957-993
Range on HMM: 3-40/44.0
LAKMNLSHNKLNFIGD-LSEMTDLRTLNLRYNRISSIK
| . .||.|..  ..  |. ...|.|||| .|.||...
LevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls

LRR_8 Leucine rich repeat 957-1009 8.1e-07 18.4 Pfam-A 3-61 (61) alignment
Range on Protein: 957-1009
Range on HMM: 3-61/61.0
LAKMNLSHNKLNFIGD--LSEMTDLRTLNLRYNRISSIKTNA----SNLQNLFLTDNRI
| . .||.|.| .|..  .. .. |..|.|..|...|| ..|     .|. |.| .||.
LkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl

LRR_4 Leucine Rich repeats (2 copies) 998-1033 5.1e-07 19.1 Pfam-A 2-40 (44) alignment
Range on Protein: 998-1033
Range on HMM: 2-40/44.0
NLQNLFLTDNRISNFED---TLPKLRALEIQENPITSIS
||. | |..|.|.. .     ||.|. | .. |||...|
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls

LRR_8 Leucine rich repeat 1041-1099 6e-08 22.0 Pfam-A 2-61 (61) alignment
Range on Protein: 1041-1099
Range on HMM: 2-61/61.0
NMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQEI-SKLTKLVFLSVARNKL
| ..| |.. .|..|| . . .|| |..| |. |||.... |. ..|..|  |..  |.|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl

LRR_4 Leucine Rich repeats (2 copies) 1066-1104 1.3e-10 30.6 Pfam-A 3-41 (44) alignment
Range on Protein: 1066-1104
Range on HMM: 3-41/44.0
LEKLELNQNNLTRLPQEISKLTKLVFLSVARNKLEYIPP
||.| |..||.. || |...|..|  |....|... ...
LevLdLsnNnIkdlppelanLpnLktLnLsnNpisdlsa

LRR_4 Leucine Rich repeats (2 copies) 1087-1125 5.7e-12 34.9 Pfam-A 1-39 (44) alignment
Range on Protein: 1087-1125
Range on HMM: 1-39/44.0
TKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDF
|.| .|. ..|... .||||..|..|.||.| .|.| |.
tnLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdl

LRR_8 Leucine rich repeat 1088-1143 9.3e-10 27.8 Pfam-A 2-60 (61) alignment
Range on Protein: 1088-1143
Range on HMM: 2-60/61.0
KLVFLSVARNKLEYIPPEL-SQLKSLRTLDLHSNNIRDFVDGM-ENL-ELTSLNISSNA
.|  | . .|.|..||..  ..|..|..|||..||.    ... ..|  |..||.|.| 
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNr

LRR_8 Leucine rich repeat 1189-1222 1.3e-06 17.7 Pfam-A 25-61 (61) alignment
Range on Protein: 1189-1222
Range on HMM: 25-61/61.0
VNLKVLNLSYNNFSDVSH---MKLESITELYLSGNKL
 |||||.||.|| . .|     .|.|..||.||||.|
snLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl

LRR_4 Leucine Rich repeats (2 copies) 1190-1226 4.2e-09 25.8 Pfam-A 2-40 (44) alignment
Range on Protein: 1190-1226
Range on HMM: 2-40/44.0
NLKVLNLSYNNFSDVSH--MKLESITELYLSGNKLTTLS
||.||.||.|| .|...   .| . ..|.||.|... ||
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpisdls

LRR_8 Leucine rich repeat 1211-1269 2.7e-09 26.3 Pfam-A 2-61 (61) alignment
Range on Protein: 1211-1269
Range on HMM: 2-61/61.0
SITELYLSGNKLTTLSGDTVLKWSSLKTLMLNSNQMLSLPAEL-SNLSQLSVFDVGANQL
...||.||.|.|.... ..  ..|.||.| |..|   |...|. ..| .|.  ..  |.|
nLkeLdLsnNrlkviptgsFkglsnLkvLdLsgnnlksispeafkgLpsLreLnLsgNrl

LRR_4 Leucine Rich repeats (2 copies) 1235-1275 3.5e-07 19.7 Pfam-A 2-41 (44) alignment
Range on Protein: 1235-1275
Range on HMM: 2-41/44.0
SLKTLMLNSNQMLSLPAELSNLSQLSVFDVGANQLKyNISN
.|..| |..|.  .||.||.||..| . ..  |..  ..|.
nLevLdLsnNnIkdlppelanLpnLktLnLsnNpis.dlsa

0034914 PP2C-like 1338-1624 3.7e-52 170.0 In-house 3-290 (295) alignment
Range on Protein: 1338-1624
Range on HMM: 3-290/295.0
PDENVNFRLRTTASIINGMRYGVADTLGQRDYVSSRDVTFERFRG-NDDECLLCLHDSKNqnadyGHNISRIVRDIYDKILIRQLERY---GDETDDNIK
.... ...|... | .. .|.|||.. |.|..   . ... ..   ..| .|... |  .     ||.......... ..|...||..    ......|.
llslpllellllsslllllrvgvasdqGrrksneDavlvvlnllslledlllfgvfDGhg.....Ghaaaevasellvelllellekllllltlsledie

TALRFSFLQLNKEINGMLNSVdngadvanlsYADLLSGACSTVIYIRGKKLFAANLGDCMAILSkNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKL
.||| .||....|.  .. .           . .. ||.. .|..|||.||. ||.||. |.|. .|| .. ||. | |. ..|.|||. .||.|..| .
ealrkaflaadeellelallr..........pelagsGtTavvalirgnklyvanvGDSravll.rngelvqltvdhkpvnelererilsaggavshgrv

DGVVDVSRAVGFFDLL---------PHIHASPDISVVTLT-KADEMLIVATHKLWEYMDVDTVCDIAREN---STDPLRAAAELKDHAMAYGCTENITIL
 ||  |.||.|.|||.         |...| ||..|..|| . |..|..|.. ||.... ....||.|..   ..|.  || || |.|.|.|...|||..
ngvlavtRalGdfdlklllslllleplvsaePdvtvleltledddfllLasDGlwdvlsneeivdivrsllakgldleeaaeeLvdlAlargsrDNiTvv

CLAL
.. |
vvrl

PP2Cc_SM00332 1354-1621 6.9e-46 149.8 In-house 8-273 (274) alignment
Range on Protein: 1354-1621
Range on HMM: 8-273/274.0
NGMRYGVadTLGQRDYVSSRDVTFERFR--GNDDECLLCLHDSknqnaDYGHNISRIVRDIYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEINGML
.|..||.  .  |   .| .|... ...   ..|  . .. |        |......|..   ..|...|.   || .|... ||. .||....||. . 
lglsygk..ssmqgwrksmeDahvvvvdlveeedwlffgvfDG.....hgGsevakfvskklpealkeelkkkkdeleddveealkkaflstdeeileee

NSVDNGAdvanlsyadLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGdYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLL--
.|  .            |||.. .|.......|. ||.||. |.|..|.     |...| | . .|..||. .||.|..|...|.  |||| | ..|   
qskelen.........alsGstavvallkkedlyvanvGDSravlcrngk.avqlsvdhkpedederkRikkaggvvekgrvngglavsrafGdhflkkn

-----PHIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENS-----TDPLRAAAELKDHAMAY-GCTENITILC
     |.| | ||..|||||..||.||.|.  ||.... ..|.|| |.        || .||..| ..|... |...|||...
kklkepyitaepdvkvvtltsedeflilaSDGlwdvlsnqevvdivrkllakgktndpqeaaelldeeairrggseDniTvvv

subfamily_PPM1A_pd Subfamily PPM1A 1354-1624 1.4e-30 99.6 In-house 10-280 (282) alignment
Range on Protein: 1354-1624
Range on HMM: 10-280/282.0
NGMRYGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNqnadyGHNISRIVRDIYDKILIR--QL--ERYGDETDDNIKTALRFSFLQLNKEING
||.||||. . | |     . ..  .. .  |  .  ..|        |......| .   . ...  .|  .   ....|..| ||| .||.|...|..
nglrygvssmqgwrvemEDahtvvaslgalkdwsfFavfDGHa.....GsevakyvkkhllenileeeelkeaaleasekdevkealrqgfLaldeaire

MLNSVDNGaDVAnlsyadllsGACSTVIYIRGKKLFAANLGDCMAILSKNnGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLL
. .....  | .         |. .... .. |.|. |||||. |.|..| |  . ||. | |.. .| .||.  || | .....|   ||||.| ... 
lstdlkta.dks.........GsTavtvlvsekhliianlGDsRavlcrn.gkaaflteDHkpsrpkEkkRieqAGGsvvvsRvnGaLAvsRalGDyeyk

P---------HIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIAREN---STDPLRAAAELKDHAMAYGCTENITILCLAL
          .. |.|.. ..  .. |. |..|   .|. .. ..|....|..   .... . |..| |.|.  | ..|...| ...
eeeekkaeeqlvsaepevtsierseeddflvlacDGiwDvlsdeevvelvrkrlevadeleevakalvdkalekgsrDNlsvlvvlf

subfamily_LRR-PP2C_pd Subfamily LRR-PP2C 1358-1623 7.9e-32 103.5 In-house 8-252 (255) alignment
Range on Protein: 1358-1623
Range on HMM: 8-252/255.0
YGVADTLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNqnadyGHNISRIVRDIYDKILIRQLERYGDetddNIKTALRFSFLQLNKEIngmlnsvdng
 | .|..|.|  .  . | .  ||...|| ...| |        |.. ...  .   |||   |. .      | . .|. .. ...  |          
vgfsdmiGrrptmedelviyGsfrdksdedyyalfdGhg.....Graaakfaseelykilaelldlnna....nPvkslkkaykeistqi..........

advanlSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNG----KLDGVVDVSRAVGFFDLLPHIH
      |      |. .....| ..| . ||.||  ..|....|  . |.  | |.. .| .||.  || | ..    ...| . ||||.|   | |.. 
......serpkfiGttaasvliiedkvyianvGdsrvvlcqkdgtakrlsldhkPseeseekriselGGtvvstvvtsrvnGtlavsralGdsflePfvv

ASPDIS-VVTLTKADEMLIVATHKLWEYMDVDTVCDIAReNSTDPLRAAAELKDHAMAYGCTENITILCLA
. ||.|  .. .| |. ||.|   .|. .  .  ..|.  ...|| .|| .|.|.|   | |.||... . 
pdPdlsqsleiskkdkflilacdGiwdlisdeeaveiva.gisdpekaaeklrdlayssGstdnisvivik

subfamily_PPM1L_pd Subfamily PPM1L 1363-1624 5.4e-20 64.8 In-house 12-266 (269) alignment
Range on Protein: 1363-1624
Range on HMM: 12-266/269.0
TLGQRDYVSSRDVTFERFRGNDDECLLCLHDSKNQNADYGHNISRIVRDIYDKILIRqlerygdetDDNIKTALRfsfLQLNKEINGMLNSVDNGAdVAN
 ||.|. .  |    |  . . .| .....| .  .    .  ...|..|..|..           | . . ..    .. .| ..  . |||.   . .
vlGrrprmedrfeieediknktgesffavfdGhGGefaaefakdvlvkaiknkliel.........dadkentep...infsklltdeilsvdekl.lek

LSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVN-NG--KLDGVVDVSRAVGFFDLLPH--IHASPD
.  |  ..|. . .  .....|  ||.||   .|  ..|    |. .| | . .|  ||. .||..  .|  .. ||. .|||.| . |  .  . |.||
akraediaGttalialvqesdlivanvGdsrGvlydkrGkaiplsfdhkpqqvkerkrikkaGGfiafrGvwrvaGvlatsralGdyplkdknlviadpd

ISVVTLTKA-DEMLIVATHKLWEYMDVDTVCDIARENSTDPLRAAAELKDHAMAYGCTENITILCLAL
|    | .   |.||.|.  ||. .  .  .  ..|.  .|   |  |  ..   |...|||.| . |
iltfdlddhkpeflilasdGlwdtfsneeavrfikerlkepdfGakslvlesfkrGsvdnitvlvvkl

PP2C Protein phosphatase 2C 1374-1617 6.3e-62 202.4 Pfam-A 2-255 (255) alignment
Range on Protein: 1374-1617
Range on HMM: 2-255/255.0
DVTFERFRGNDDECLLCLHDSKNQNADyGHNISRIVRDIYDKILIRQLERYGDETDDnIKTALRFSFLQLNKEINGMLNSVDN-GADVANL-SY--ADLL
||......| ..... .... ||...  ....|. . ...|.. .|....| .|. .  . ... |||.|.|. ... .|. .  ... .. .   ... 
dvgaselqgarksmedahialknleks.sgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfladtdeelksskantepsk

SGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVN-NGKLDGVVDVSRAVGFFDLLP----HIHASPDISVVTLT
||....|..||||||. ||.||..|.|.........||..| |....|.|||. .||.|. ||.. |...||||.| |.| |    ...|.||...|.||
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklt

KADEMLIVATHKLWEYMDVDTVCDIARENSTD---PLRAAAELKDHAMAYGCTENI
. ||.||.|.. ||.... ....|..|.. ..   | .|| || |.|.|.|...||
eedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PP2C Protein phosphatase 2C 1374-1617 6.3e-62 202.4 In-house 2-255 (255) alignment
Range on Protein: 1374-1617
Range on HMM: 2-255/255.0
DVTFERFRGNDDECLLCLHDSKNQNADyGHNISRIVRDIYDKILIRQLERYGDETDDnIKTALRFSFLQLNKEINGMLNSVDN-GADVANL-SY--ADLL
||......| ..... .... ||...  ....|. . ...|.. .|....| .|. .  . ... |||.|.|. ... .|. .  ... .. .   ... 
dvgaselqgarksmedahialknleks.sgkssvaffavfdghggreaakyarehle.eilkeqksflelekvekalrksfladtdeelksskantepsk

SGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVN-NGKLDGVVDVSRAVGFFDLLP----HIHASPDISVVTLT
||....|..||||||. ||.||..|.|.........||..| |....|.|||. .||.|. ||.. |...||||.| |.| |    ...|.||...|.||
sGstavvalirgkklyvAnvGDSravLcrkdnakkeltedHkpsdedEreRIeeaggsvsnngrvngsLavsRalGdfelkpkeeqlvsaePdvtsvklt

KADEMLIVATHKLWEYMDVDTVCDIARENSTD---PLRAAAELKDHAMAYGCTENI
. ||.||.|.. ||.... ....|..|.. ..   | .|| || |.|.|.|...||
eedefliLasdGlwdvlsdqeavdlvrselskkkspmeaaeelvdeaiargsedni

PPM_PTC7 1374-1617 2.8e-61 200.2 In-house 2-259 (259) alignment
Range on Protein: 1374-1617
Range on HMM: 2-259/259.0
DVTFERFRGNDDECLLCLHDSKNQNADyGHNISRIVRDIYDKILIRQLERYGDETDDnIKTALRFSFLQLNKEINGMLNSVDN--GADVANL----SyAD
|. ...|.|  .... .... .| ..  ....|. .  ..|....|....| .|. .  . ..| || .|.| .... .|. .   ... ..    . ..
dggasafqgfrksmedahialanless.sgkdsvaffavfdghggreaakyarehle.eilkerksfeeleklekalrksflaldtdeelksseant.ep

LLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVN---NGKLDGVVDVSRAVGFFDLLP------HIHASPDI
. ||.. .|..|.|.||. ||.||..|.|.........||..| |....|.|||...||.|.   ||.. ||..||||.| |.| |      ...|.|||
stsGstAvvalitgsklyvAnvGDSravLcrsgnavkqltedHkpsnedEreRiegaggsvsnvgngrvngvlavsRafGdfelkpketeeqlvsaePdi

SVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENSTD--PLRAAAELKDHAMAYGCTENI
|...... ||.||.|...||.... ....|..|..  .  | .|| .| |.|.|.|...||
sstkideedefliLasdGlwdvvsdqeavdlvrselskkdpmeaaeklvdeaiargsedni

PPM_PTC7_SpoIIE 1375-1616 1.6e-21 70.2 In-house 3-229 (230) alignment
Range on Protein: 1375-1616
Range on HMM: 3-229/230.0
VTFERFRGNDDECLLCLHDSKNQNADyGHNISRIVRDIYDKILIRQlerygDETDDNIKTALRFSFlQLNKE-INGMLNSVDNG--AD---VanlsyaDL
. . ...|  .... .... .| ..  ... ...|  ..|   .|.       .   ..||||    . . |  .  |.  .    ||          . 
ggasaaqgarksmedahispanseks.sggrlalvvgdvdGhGgra.....alamgllrtalrela.faglekpeeilrrlnlalaadlede......ps

LSGACSTVIYIRGKK--LFAANLGDCMAILSKNNGDyqtltkqhlptkreEYERIrISGGYVN----NGKLDGVVDVSRAVGFFDLLP---HIHASPDiS
 |||. .|..|.. .  |  ||.||. ..|....|               | |||  .|| .     .|   ||. ||.| | . ||.    . |.|| .
ssgaTavvalidpstgklyvanaGdsppllvrddgg..............ereri.vagglpslGilpgrvfgvlavslapGdllllytDGvveaepd.t

VVTLTKA-DEMLIVATHKLWEYMDVDTVCDIARENSTDPlrAAAELKDHAMAYGCTEN
. ....  ||.||.|. .||.... . ..|..|..  .|  || .|............
sdgelfgkdeflilasdglwdvlspqelvdlvrdelekp..aaeglleDDitllvvrv

0049733 PP2C-like 1402-1623 9.2e-27 87.0 In-house 37-232 (235) alignment
Range on Protein: 1402-1623
Range on HMM: 37-232/235.0
GHNISRIVRDIYDKILIRQLERygdETDDNIKTALRFSFLQLNKEINGMlnsvdngadvANLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKnNG
||. ........ ..|...|..    .  ....||| .||..|...  .          |  |.    .|.. .|....|.||. ||.||. |.| . .|
ghaagevasellvetllellle...lllldleealrkaflaaneallel..........alaspelagmgtTavvalldggklyvanvGDsrayllr.dg

DYQTLTKQHLPTKREEYERIRISGGYVnngKLDGVVDVSRAVGffDLLPHihasPDISVVTLTKADeMLIVATHKLWEYMDVDTVCDIAREnsTDPLRAA
  . ||. | |. ..|..||.  ||.|      |.  ..||.|  ||| .    ||..|..|.. | .|..|.  ||.... ....|. |.  .|.  ||
klvqltedhspvnelerqriitaggav...rvpgrlaltralG..dlllk....pdvtvlelepgd.flllasDGlwdvlsdeeivdllrs..ldleeaa

AELKDHAMAYGCTENITILCLA
 .| ..|.|.| ..|||.... 
erlvelalarggrDNiTvvvvr

subfamily_PHLPP_pd Subfamily PHLPP 1403-1623 9.4e-25 79.9 In-house 39-244 (246) alignment
Range on Protein: 1403-1623
Range on HMM: 39-244/246.0
HNISRIVRDIYDKILIRQLERygdetDDNIKTALRFSFLQLNKEINGMLNSVDNGADVANLSyadllsgaCSTVIYIRGKKLFAANLGDCMAILSKNNGd
...|... ..  ..|  ....     | | .  ... .|. ....    . .   | .  .          ..|   .  .|  |. | . |.| .|.  
eelssllqrlmkdvlkeevqk.....dkneeeymkntllvaqrklGeaGeklgsaallilir........hdkvdPaksfsLevAsvGtlqavliRngk.

YQTLTKQHLpTKREEYERIRISGGYVN-NGKLDGVVDVSRAVGFFDLLPHIHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENsTDPLRAA
  .|.|..   ...|..||.   .... ..|..||.  .| .|.. | | .  .| .. |.||. ||.|||  ..||| ...| . .  |..  ||| ||
klrlsksyv.iekdelkrikeakaiitednkingviestrllGytflfPvvlPkphvrevlLteqdellivGnkalWevlsideaveavrke.edplvaA

AELKDHAMAYGCTENITILCLA
  | | | .||.......| . 
kklvdlaqsygaadsvsvlvvr

subfamily_PDP_pd Subfamily PDP 1411-1523 1.2e-14 47.2 In-house 94-209 (398) alignment
Range on Protein: 1411-1523
Range on HMM: 94-209/398.0
DIYDKILIRQLERYGDETDDNIKTALRFSFLQLNKEI-NGMLNSVdNGADVANlSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGDY----QT
. . . | ..|..  . . ...| ||. .||.| |.| .  |... .. .... . .  |||||... .|.|..|. || ||| |.| .....      .
klslselskylqelleaevekvkealkkaFlklDkdistealkkl.kekslre.allvalsGacallaliegtelhvAntGDcravlgvqeeegsweavk

LTKQHLPTKREEYERIRI
|.|..  . .|| |||. 
LskdqtadneeEveRikk

subfamily_PPM1K_pd Subfamily PPM1K 1417-1623 1.5e-22 73.0 In-house 53-257 (263) alignment
Range on Protein: 1417-1623
Range on HMM: 53-257/263.0
LIRQLERYGdETDDNIKTALRFSFLQLNKEINGMLNSVDNGAdvanlsyADLLSGACSTVIYIR-GKKLFAANLGDCMAILSKnNGDYQTLTKQHLPTKR
| . |.|.  | ...... |. .|..|.|...  |.     |         | ||. .||  .| |..|  |.|||  ||| . ||. . ||. | | ..
lekilkrll.ekekdleivlknafeeldkklkrylefsvaea.......ellssGttatvsllrdGtelvlaslGdsrailcr.nGkakkltrdhdPele

EEYERIRISGGYVNNG-----KLDGVVDVSRAVGFFDLLPH-IHASPDISVVTLT-KADEMLIVATHKLWEYMDVDTVCDIAReNSTDPLRAAAELKDHA
|| |||. .|| |.       ...|.. ..|..| .|| .. . | |.   . .  .|| .|.. |  .   ..   .||. |   .|| .||  | . |
eekerikaagGsvewnslgkplvngrlamtrslGdldlkryGviatPetkslkvdhaadsflvlitdgisfvvnsqelcdlvr.lchdpeeaahalteqa

MAYGCTENITILCLA
. ||. .| |.. . 
lqygsednatavvvp

subfamily_PPM1G2_pd Subfamily PPM1G2 1418-1614 3.2e-21 68.5 In-house 75-270 (287) alignment
Range on Protein: 1418-1614
Range on HMM: 75-270/287.0
IRQLERYGDETDDNIKTALRFSFLQLNKEINGMlnsvdngadvanLSYADLLSGACSTVIYIRGKKLFAANLGDCMAILSKNNGdYQTLTKQHLPTKREE
|. ...  . ........|. .||....|.                . .|  .|. ..|. |. .||. || ||  |.||..    ..|.  | |.. .|
ikkiakkksfkegaleqilkdafletDeellkd............eklkdesaGstavvvlikeeklyvanaGDsravlsskgn.vkalsfDhkPqeese

YERIRISGGYVNNGKLDGVVDVSRAVGFFDLLPH---------IHASPDISVVTLTKADEMLIVATHKLWEYMDVDTVCDIARENS---TDPLRAAAELK
 .||  .||.|. ..  |.. .|||.| |    .         . | ||. |  |.. || |..|   .|. .  ..|.|. ||.    ... . . || 
kkriiaagGfvelnrvngnLalsralgDfefkknvkkkpeeqivtavPDvlvkkldeddeflvLaCDGiWDvltnkevvdlvrerlvsgakldeiieell

DHAMAYGCT
|...|  . 
dkclapdss

subfamily_PPM1D_pd Subfamily PPM1D 1418-1537 4.8e-13 41.9 In-house 61-178 (309) alignment
Range on Protein: 1418-1537
Range on HMM: 61-178/309.0
IRQLERYGDETDDNIKTALRFSFLQLNKEingMLNSVDNGADVANLSYAdlLSGACSTVIYIRGKKLFAANLGDCMAILSKNNG-----DYQTLTKQHLP
|.. . .  . .... .|.| .||.....   | .. .. .  ..  ..   .|.  .|. ||..||. |. ||  ..|....        ..|||.| |
ikkqkkflssepedvleAireaflathea...mkkkleeWpktksglls..taGttasvviirreklyvahvGDsaivlgvkepkekklrakeltkdHkP

TKREEYERIRISGGYVNNGklDGVV
 . || |||. .|| | .    || 
espeekerieelGGevaak..sGvk

subfamily_Choan-PPM1K-like_pd Subfamily Choan-PPM1K-like 1451-1535 5.9e-07 22.3 In-house 64-155 (292) alignment
Range on Protein: 1451-1535
Range on HMM: 64-155/292.0
LN-SVDNGADVANLSYADLLSGACSTVI-YIR-GKKLFAANLGDCMAILSK--NNGDYQ--TLTKQHLPTKREEYERIRISGGYVNNGKLDG
|.  .| .| . .|     .|.. ..|   .| ...|. ||.||  |.| .     ||.   |...| |   .| .||. .||.|.  .. |
llrildiaakldkltidaresattavvcarvrddralilanvGdsrallgrclggsdyeliPlsrdhkPedPderarilraGGrveptrvrg

subfamily_PPM1E_pd Subfamily PPM1E 1467-1622 6e-23 74.4 In-house 99-260 (265) alignment
Range on Protein: 1467-1622
Range on HMM: 99-260/265.0
DLLSGACSTVIYIRGKKLFAANLGDCMAILSKNnGDYQTLTKQHLPTKREEYERIRISGGYVNN---GKLDGVVDVSRAVGFFDLLPHIHASPDISVVTL
 | ||. . |. |....|. | |||  |.| .. |.  .|.| | | . .| .||   || | .    . .||. ||||.|  .| |.. . .|.. |.|
klksGstavvvliekdqlyvaWlGDsqallvrk.geavqlmkpHkPeredEkkRieeagGlvvvigawRvnGvLsvsRaiGDvklkpyvsgeadvaevel

TKADEMLIVATHKLWEYMDVDTVC----DIARENSTDPLRAAAELKDHAMAYGCTENITILCL
....|.||.|.  ||. .. ..|.    . ......|  ..| .| ..|   | ..|||..  
dgseeylilacDGlwDvvneeevvklveefladgaedlsevakllveaakeagssDnitvvvv

subfamily_PPM1G_pd Subfamily PPM1G 1470-1595 5.3e-21 68.1 In-house 296-430 (473) alignment
Range on Protein: 1470-1595
Range on HMM: 296-430/473.0
SGACSTVIYIRGKKLFAANLGDCMAILSKNnGDYQTLTKQHLPTKREEYERIRISGGYVN-NGKLDGVVDVSRAVGFFD-----LLPH----IHASPDIS
||.  .|. ...|||. || ||. ..||.| |    |   | |   .| |||.  || |. .|...| ...|||.| .       ||.    | | ||| 
sGttAvvaLlkekklivAnaGDsRcvlsrn.GkAldlslDHkPeDevEleRiekAGGkvdedgRvnGGLnlsRAlGDhaYkkneeLplkeqmisAlPDik

VVTLTKADEMLIVATHKLWEYMDVDTVCDIARENST
| |||..|| |..|.  .| .|. . | |  |.. .
vltlteedeFlvlAcDGiWnvmesqevvdfvraklk

subfamily_ILKAP_pd Subfamily ILKAP 1471-1591 1.2e-21 70.1 In-house 114-240 (293) alignment
Range on Protein: 1471-1591
Range on HMM: 114-240/293.0
GACSTVIYIRGKKLFAANLGDCMAILSKNNGDYQ-----TLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSRAVGFFDLL-PHIHASPDISVVTLT
|.  ||. .  . |. |||||  |.| ... . .     .|||.| |.| || .||. .||.|..|.. ||..|||..|        . . ||.. ..||
GstatvvlvldnvlyvanlGdskavlvrkkeegdkiasvvLtkdhtpvkyeerkriqkaGgvvrdgrvlGvlevsrsiGdgrfkrlGvistPdvkkceLt

KADEMLIVATHKLWEYMDVDTVCDIAR
. |  ...|   ||. ...| | . . 
endlfvvlaCdGLwkvfsadevvkfil

subfamily_PP2D1_pd Subfamily PP2D1 1479-1591 2.3e-15 49.3 In-house 185-303 (492) alignment
Range on Protein: 1479-1591
Range on HMM: 185-303/492.0
IRGKKLFAANLGDCMAILSKNnGDYQTLTKQHLPTKREEYERIRISGGYV----NNGKLDGVVDVSRAVGFF---DLLPHIHASPDISVVTLTKADEMLI
.    |. || |.  |.| .. |   .||..| |  ..| .|.. .|. |    .||. .|..|. | .|..   .|   .   | .  |.|..|. .|.
eelgvlyianaGnvqAvLcre.GkaiiLtreHtprnkkERtRvekagsvvvkseknglvnGildttRGLGnyGdpkLkksvipePkttsvkldeaaqflv

VATHKLWEYMDVDTVCDIAR
.|.  ||| .. . |  ...
lAsnGlWevlseeevlsLvk

PPM_PTC7_motif 1571-1617 1.1e-13 44.5 In-house 1-51 (51) alignment
Range on Protein: 1571-1617
Range on HMM: 1-51/51.0
IVATHKLWEYMDVDTVCDIARENSTD----PLRAAAELKDHAMAYGCTENI
| |.. ||.... ....|..|.. ..    | .|| .| |.|.|.|.. ||
iLAsDGLWDvlsdqeavdlvrdqlskkglspqeaAeklvdealargseDni

Guanylate_cyc Adenylate and Guanylate cyclase catalytic domain 1662-1836 8.9e-32 96.3 Pfam-A 4-173 (184) alignment
Range on Protein: 1662-1836
Range on HMM: 4-173/184.0
PPTGNLAMVFTDIKSSTFLWELF-PNAMRTAIKTHNDIMRRQLRIYGGYEVKTEGDAFMVAFPTP---TSGLTWCLSVQLKLLDAQwPEEITSVQdgcqv
... .....|.||...| |..   | .. .......  ....|. .|.|.||| |||.|||. .|   .. . ......|.||.|   |. .. .     
esydevtilFadIvgftalssehepeelvkllnelitrfdelldekgvykvktiGdaymvasglpeekaahaaklaelaLdlleal.eevaieek.....

tdrngniiyQGLSVRMGIHWGCPVPELD-LVTQRMDYLGPMVNKAARVQGVADGGQIAMSSDFYSEFN-----KIMKYHERVVKG
         .||..| ||| |  | ...  .. |.|. |  || |.|.. ....|.|..|.  |.  .     .. .  |  |||
.........eglklrvGihtGtvvagviGakkprydvfGntVnlAsrmestgkkgkiqvseetyellkeeeqfeltergevevkg