Synonym: YJL155C, FBP26
Gene expression:
Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
6PF2K | 6-phosphofructo-2-kinase | 3-224 | 3.5e-96 | 310.9 | Pfam-A | 3-223 (223) | alignment | ||
Range on Protein: 3-224
Range on HMM: 3-223/223.0
YSTISNDNDIKVCVIMVGLPARGKSFISQKIIRYLSWLSIKAKCFNVGNYRRDVSGNvPMDAEFFNFENTDNFKLRELAAQNAIKDIVNFFTKEDGSVAV
.||..|... |.....||||||||..||.|..|||.||....|.||||.|||... . ..|||||...|....|||| .|..|.||.......|.|.||.
qstvknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavka.lsdaeffrpdneealklreklalaalkdllkylneeegqvai
FDATNSTRKRRKWLKDICEKNNIQPMFLESWSNDHELIINNAKDIGSTSPDYENSEPHVAEADFLERIRQYERFYEPLDPQKDKDMTFIKLVNIIEEVVI
|||||.||.|||......|.||....||||...|.|.| .| |.. ..||||...|.. | .|||.|...||..|||||...|.....||.... ...|.
fDAtNttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvidvgkslvv
NKIRTYLESRIVFYVMNIRPKP
|....||.||||.|..||. ||
nnvqgylqsrivyyllNihlkp
|
|||||||||
AAA_33 | AAA domain | 16-125 | 1.3e-08 | 25.3 | Pfam-A | 2-97 (143) | alignment | ||
Range on Protein: 16-125
Range on HMM: 2-97/143.0
VIMVGLPARGKSFISQKIIRYLSwlsikAKCFNVGNYRRDVSGnvpM---DAEffnfentDNFKLRELaAQNAIKDIVNFFTKEDGSVaVFDATNSTRKR
|..||||. |||. ...... | . . ..|| . | . . . | .... . ....... .. .|| ..|||| .|..
vllvGlpGsGKstlaerllkklg.....yvrlsqdtlrrrlfg...tdqqslt.......dytrvlkr.lyqilnklarkalsagrsv.ivdatnlsree
RKWLKDICEKNNI
|... ..... .
rarfvklakrlgv
|
|||||||||
DUF3768 | Protein of unknown function (DUF3768) | 163-208 | 6.5e-06 | 12.6 | Pfam-A | 14-56 (84) | alignment | ||
Range on Protein: 163-208
Range on HMM: 14-56/84.0
EADFLERIRQYERFYEPLDPQKDKDMTFIklvNIIEEVVINKIRTY
...|...|....| . || . .|. .. .. .| |. || .|
qqeilravrafddftpdnDPhgehDfGav...evegekvfwKiDyY
|
|||||||||
0037864 | Phosphoglycerate mutase-like | 218-407 | 4.7e-49 | 158.9 | In-house | 1-203 (211) | alignment | ||
Range on Protein: 218-407
Range on HMM: 1-203/211.0
MNIRPKPKYIWLSRHGESIYNVEKKIGG--DSSLSERGFQYAKKLEQLVKESaGEINLTVWTSTLKRTQQTANYL----P---YKKLQWKALDELDAGVC
|....... ..| ||||. .|.|... | |. |.|.| ..|..| ..... | |..|.|.|..|||... . .. ....| |.| |..
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadl.glpfdavysSpllRaiqTaeiilealglpllpvevdprlrErdfgal
DGMTYEEIEKEYPEDFKARDNDKYEYRYRGGESYRDVVIRLEPVIMELERQ-----ENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIKLEPRA
.|.|.|||...|||.. |. .|.| .|. ||||..||| |..|...|| .. ||||...|..|||...||..... || ... .| .....|| .
egltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsleellrlnlpngsvtvleldd
YGTK
.| .
ggwv
|
|||||||||
subfamily_PFKFB_pd | Subfamily PFKFB | 219-415 | 2.6e-90 | 293.2 | In-house | 1-197 (198) | alignment | ||
Range on Protein: 219-415
Range on HMM: 1-197/198.0
NIRPKPKYIWLSRHGESIYNVEKKIGGDSSLSERGFQYAKKLEQLVKESAGEiNLTVWTSTLKRTQQTANYLPYKKLQWKALDELDAGVCDGMTYEEIEK
||. ||. |.|.||||| .|....|||||.|.||| .|||||.. .||. . .|.||||.||||.|||..| ..| |||||||||||.|||.|||||..
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfikeenlk.elrvwtselkrtiqTaellglpkeqwkaLdeldaGkcdgltyeeike
EYPEDFKARDNDKYEYRYRGGESYRDVVIRLEPVIMELER-QENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIKLEPRAYGTKVTKIKANI
..||.||.|..|||.|||..||||.|.| ||||||.|||| |||||||.||||||...||... .|| |....||||.|||.|.|||.||...| ..
kfpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylkvplhtvikltpvaYgckvellkldv
|
|||||||||
0051064 | Phosphoglycerate mutase-like | 223-414 | 1.3e-48 | 158.3 | In-house | 2-231 (241) | alignment | ||
Range on Protein: 223-414
Range on HMM: 2-231/241.0
KPKYIWLSRHGESIYNVEKKIGG--DSSLSERGFQYAKKLEQLVKESaGEINLTVWTSTLKRTQQTAN----YLP---YKKLQWKALDELDAGVCDGMTY
..| ..| ||||| .|.|... | |. |.|.| ..|..| .. .. | |..|.|.|..|||. .|. .. ....| |.| |...|.|.
mmkrlyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladl.gikfdavysSpllRaiqTaeiiaealglpllpvvvdprlrEidfgalegltl
EEIEKEYPEDFKARDNDKYEYRY-------------------------RGGESYRDVVIRLEPVIMELERQ-----ENVLIITHQAVLRCIYAYFMNVPQ
|||....||.. |...|.. .|. ||||..||. |..|.. || .. .|||...|..|.|...||....|
eeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvlvVsHggvirallayllglpl
EESPWMSIPLHTLIKLEPRAYGTKVTKIKAN
|| .....| .....|| ...|..|. . |
eellrlnlpngsvtvleldddgkrvvlvlln
|
|||||||||
0053607 | Phosphoglycerate mutase-like | 224-408 | 2.8e-51 | 165.9 | In-house | 1-184 (191) | alignment | ||
Range on Protein: 224-408
Range on HMM: 1-184/191.0
PKYIWLSRHGESIYNVEKKIGGDSSLSERGFQYAKKLEQLVKESaGEINLTVWTSTLKRTQQTANYLPYKKLQWKALDELDAGVCDGMTYEEIEKEYPED
.. ..| ||||. .|.|... ||..|.|.| ..|..| .| .| | |..|.|.|..|||... .. ....| |.|.|...|.|.||....|||.
mtrlyLvRHGetewnaegrlqgdvpLtelGreqaralaellael.glkfdavysSpllRarqTaeiiglpvevdprlrEidfgdwegltleelaekypee
FKARDNDKYEYRYRGGESYRDVVIRLEPVIMELERQENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIKLEPRAYGTKV
. |. .|.. ||. ||||..||. |..|...|| ...|||...|..|.|...||....| || .....| .....||.. .| ..
laawlrdpldyrppggEsladvaaRvlpaleellaggnvlvVaHggvirallayllglpleellrlnlpngsvtvlelddggwvl
|
|||||||||
0043909 | Phosphoglycerate mutase-like | 224-408 | 4.9e-49 | 159.3 | In-house | 2-228 (249) | alignment | ||
Range on Protein: 224-408
Range on HMM: 2-228/249.0
PKYIWLSRHGESIYNVEKKIGG--DSSLSERGFQYAKKLEQLVKESAGEINLtVWTSTLKRTQQTANYL----P---YKKLQWKALDELDAGVCDGMTYE
.| ..| ||||. .|.|... | || |.|.| . |..| ...|| ... |..|.|||..|||... . .. ....| |.| |...|.|..
mkrlyLvRHGetewnaegrfqgwlDspLtelGreqaralgealkelgipfda.vysSplkRAiqTaeiileelgldklpvevdprLrErdfGalegltka
EIEKEYPEDFKARDN-----------------------------DKYEYRYRGGESYRDVVIRLEPVIMELERQ-----ENVLIITHQAVLRCIYAYFMN
||...|||.. |. . |.. .|. ||||..||| |..|...|| .. .||||..|..|||...||...
eiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllkdggnvliVaHggvlrallayllg
VPQEESPWMSIPLHTLIKLEPRAYGTKV
.. |. .....| .....||. ..|..|
lsledilrlnlpngsitvlelddggkpv
|
|||||||||
0049178 | Phosphoglycerate mutase-like | 224-409 | 4.1e-48 | 156.4 | In-house | 3-224 (243) | alignment | ||
Range on Protein: 224-409
Range on HMM: 3-224/243.0
PKYIWLSRHGESIYNVEKKIGG--DSSLSERGFQYAKKLEQLVKESaGEINLTVWTSTLKRTQQTANYL----P---YKKLQWKALDELDAGVCDGMTYE
.. ..| ||||. .|.|... | || |.|.| . |..| .| .| | |..|.|||..|||... . .. ....| |.| |...|.|..
mtrlyLvRHGetewnaegrlqgwtDspLtelGreqAralgellael.glkfdavysSplkRaiqTaeiilealglpllpvvvdprLrErdfGalegltka
EIEKEYPEDFKARDNDKYEYRY-----------------------RGGESYRDVVIRLEPVIMELERQ-----ENVLIITHQAVLRCIYAYFMNVPQEES
||...|||.. |. .|.|..|. ||||..||. |..|...|| .. ..||...|..|.|...|.....| ||
eiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktvlvVaHggvirallalllglpleel
PWMSIPLHTLIKLEPRAYGTKVT
... .| .....|| .| ...
lrlnlpngsvtvlelddggwvlv
|
|||||||||
0036887 | Phosphoglycerate mutase-like | 224-407 | 5.1e-48 | 155.6 | In-house | 1-191 (202) | alignment | ||
Range on Protein: 224-407
Range on HMM: 1-191/202.0
PKYIWLSRHGESIYNVEKKIGG--DSSLSERGFQYAKKLEQLVKesaGEINLTVWTSTLKRTQQTANYL----PYKKLQWKALDELDAGVCDGMTYEEIE
.. ..| ||||. .|||... | |. |.|.| ..|..| .... | |..|.|.|..|||... ... ....| |.| |...|.|.|||.
mtrlyLvRHGetewnvegrlqgdldvpLtelGreqaralgerla...glpfdavysSpllRaiqTaeiiaealglpvivdprlrEidfgalegltleeia
KEYPEDFKARDNDKYEYRYRGGESYRDVVIRLEPVIMELERQ---ENVLIITHQAVLRCIYAYFMNVPQEESPWMS-IPLHTLIKLEPRAYGTK
..|||...|. |.| .|. ||||..||| |......|| .. .|||...|..|||...||..... |. ... .| .....|| ...| .
ekypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklpngsvtvlelddggwv
|
|||||||||
0036777 | Phosphoglycerate mutase-like | 225-415 | 9.5e-51 | 165.0 | In-house | 3-231 (247) | alignment | ||
Range on Protein: 225-415
Range on HMM: 3-231/247.0
KYIWLSRHGESIYNVEKKIGG--DSSLSERGFQYAKKLEQLVKESaGEINLTVWTSTLKRTQQTAN----YLP---YKKLQWKALDELDAGVCDGMTYEE
| ..| ||||. .|.|... | |. |.|.| ..||.| .|.|| | |..|.|.|..|||. .|. .. ....| |.| |...|.|..|
krlyLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkel.glpfdavysSpllRAiqTaeiilealglsllpvvvdprLrErdyGalegltkae
IEKEYPEDFKARDNDKYEYRY-------------------------RGGESYRDVVIRLEPVIMELERQ-----ENVLIITHQAVLRCIYAYFMNVPQEE
|...|||.. |. .|.| ||. ||||..||| |..|...|| .. ||||...|..|||...||..... |.
iaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayllglsled
SPWMSIPLHTLIKLEPRAYGTKVTKIKANI
... .| .....|| ...|.... . |
ilrlnlpngsitvleldddgklwvleslnd
|
|||||||||
subfamily_PGAM5_pd | Subfamily PGAM5 | 226-398 | 4.1e-08 | 24.6 | In-house | 3-165 (189) | alignment | ||
Range on Protein: 226-398
Range on HMM: 3-165/189.0
YIWLSRHGEsiYNVEKKIgGDSSLSERGFQYAKKLEQLVKESAGEINlTVWTSTLKRTQQTANYLpYKKLQWKALDELDAGVCDGMTYEEIEKEypEDFK
. | |||. |..... .. |.|.| . |... . .||. . . .. .||. |...||. . |.|. . . ...| .. . . .|
hlilvrhgq..yvlddds.dkkiltelGrrqaeltGkrlkelnlkft.klvastmvravetadii.skqlpdvpkktktellreGaPikpePav..khwk
ARDNDKYEYRYRGGESYRDVVIRLEPvimELERQENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIK
. . . || | ..| .. | .| | ... ||..| |.| . . .| | .|. .. |
pealqfyedgarieaafrkyfhrasp...eqkedsyelivchanvirylvcralqlPpeawlrlslnngsitk
|
|||||||||
0035570 | Phosphoglycerate mutase-like | 227-416 | 1.6e-56 | 183.4 | In-house | 2-190 (219) | alignment | ||
Range on Protein: 227-416
Range on HMM: 2-190/219.0
IWLSRHGESIYNVEKKIGGDSSLSERGFQYAKKLEQLVKESaGEINLTVWTSTLKRTQQTANYLPYKKLQWKALDELDAGVCDGMTYEEIEKEYPEDFKA
..| ||||. .|.|... ||. |.||| ..|..| .. .. | |..|.|.|..|||... .. ....| |.|.|...|.|..||...|||...|
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadl.gipfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltldeiaekypeelaa
RDNDKYEYRYRGGESYRDVVIRLEPVIMELERQENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIKLEPRAYGTKVTKIKANIP
. .|.| ||. ||||..||| |..|...|||..||||...|..|.|...||....| || .....| .....||....| |.. . |.
wlrdpydyrppggEsladvvaRvlpaleeledgenvlvVsHggvirallayllglpleeilrlnlpngsvtvleldggggkwvlvllndt
|
|||||||||
0039931 | Phosphoglycerate mutase-like | 227-412 | 2.1e-56 | 182.9 | In-house | 2-186 (219) | alignment | ||
Range on Protein: 227-412
Range on HMM: 2-186/219.0
IWLSRHGESIYNVEKKIGGDSSLSERGFQYAKKLEQLVKESaGEINLTVWTSTLKRTQQTANYLPYKKLQWKALDELDAGVCDGMTYEEIEKEYPEDFKA
..| ||||. .|||... ||| |.||| ..|..| .. |. | |..|.|.|..|||...... ....| |.|.|...|.|.|||...|||.. |
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdl.glpfdavysSpllRaiqTaeiiglpveidprLrEidfgdlegltleeiaekypeelaa
RDNDKYEYRYRGGESYRDVVIRLEPVIMELERQENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIKLEPRAYGTKVTKIK
. .|.|.||. ||||..||| |..|...||...||||...|..|.|...||..... || .....| .....||....| ... .
wlrdpydyrppggEsladvvaRvlpaleellagenvlvVsHggvirallayllglsleeilrlnlpngsvtvlelddggwvlvlln
|
|||||||||
0048955 | Phosphoglycerate mutase-like | 227-404 | 5.8e-46 | 149.6 | In-house | 3-218 (240) | alignment | ||
Range on Protein: 227-404
Range on HMM: 3-218/240.0
IWLSRHGESIYNVEKKIGG--DSSLSERGFQYAKKLEQLVKESaGEINLTVWTSTLKRTQQTAN----YLP---YKKLQWKALDELDAGVCDGMTYEEIE
..| ||||| .|.|... | |. |.|.| ..|..| .. .. | |..|.|.|..|||. .|. .. .. .| |.| |...|.|..||.
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadl.gikfdlvysSpllRaiqTaeiiaealglpllpvvvdprlrErdfgalegltldeia
KEYPEDFKARDNDKYEYRY-------------------------RGGESYRDVVIRLEPVIMELE-----RQENVLIITHQAVLRCIYAYFMNVPQEESP
...||.. .. .|.. .|. ||||..||. |..... || ...|||...|..|.|...||....| || .
ekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgknvlvVsHggvirallayllglpleeil
WMSIPLHTLIKLEPRAY
...|| . ...|| . .
rlnipngsvtvlelddg
|
|||||||||
0050036 | Phosphoglycerate mutase-like | 227-400 | 7e-41 | 131.6 | In-house | 3-166 (171) | alignment | ||
Range on Protein: 227-400
Range on HMM: 3-166/171.0
IWLSRHGESIYNVEKKIGG--DSSLSERGFQYAKKLEQLVkesageINLTVWTSTLKRTQQTANYLPYKKLQWKALDELDAGVCDGMTYEEIEKEYPEdf
..| ||||...|.|... | |..|.|.| ..|..| .| |..|.|.|..|||... .. ....| |.| |...|.|..||...|||
lyLvRHGetewnlegrfqgwtdvpLtelgraqaralgell......pfdavysSpllRArqTaelillpvivdprLrErdfGawegltldeiaakype..
kaRDNDKYEYRYRGGESYRDVVIRLEPVIMELErqENVLIITHQAVLRCIYAYFMNVPQEESPWMSIPLHTLIKLE
.. |.. ... ||||..||. |. |.. || .|||...|..|.|...|...... || ... .| .... ||
..wlldlldlappggEsladvlaRvlpaleell..gnvlvvaHggvirallalllglsleeilrlelpngsvlvle
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 227-374 | 1.1e-35 | 115.9 | Pfam-A | 2-158 (158) | alignment | ||
Range on Protein: 227-374
Range on HMM: 2-158/158.0
IWLSRHGESIYNVEKKIGGDSS--LSERGFQYAKKLEQLVKESAGEINLtVWTSTLKRTQQTANYLPY----KKLQWKALDELDAGVCDGMTYEEIEKEY
..| ||||| .| |... |.| |.|.| . |..| . |.. .|. |.||.|||..|||..| . . ..| |.|.|...|...||...|.
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpida.vytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef
PEDFKARDNDKYEYRYRGGESYRDVVIRLEPVIMELE----RQENVLIITHQAVLRCI
||.......||.|.|. .|||..||. |..|...|| ..|||||..|..|||..
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
|
|||||||||
His_Phos_1 | Histidine phosphatase superfamily (branch 1) | 227-374 | 1.1e-35 | 115.9 | In-house | 2-158 (158) | alignment | ||
Range on Protein: 227-374
Range on HMM: 2-158/158.0
IWLSRHGESIYNVEKKIGGDSS--LSERGFQYAKKLEQLVKESAGEINLtVWTSTLKRTQQTANYLPY----KKLQWKALDELDAGVCDGMTYEEIEKEY
..| ||||| .| |... |.| |.|.| . |..| . |.. .|. |.||.|||..|||..| . . ..| |.|.|...|...||...|.
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkkLkradlpida.vytSplkRaiqTaeilleeldipiikeprLrerdfgeweglpkeevkeef
PEDFKARDNDKYEYRYRGGESYRDVVIRLEPVIMELE----RQENVLIITHQAVLRCI
||.......||.|.|. .|||..||. |..|...|| ..|||||..|..|||..
peeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
|
|||||||||
subfamily_TIGAR_pd | Subfamily TIGAR | 227-359 | 1.2e-11 | 36.7 | In-house | 3-137 (222) | alignment | ||
Range on Protein: 227-359
Range on HMM: 3-137/222.0
IWLSRHGESIYNVEKKIGGD--SSLSERGFQYAKKLEQLVKesAGEINLtVWTSTLKRTQQTANYLP----YKK----LQWKALDELDAGVCDGMTYEEI
... ||||...| || . | . |||.|.. ||.. . .. . .||. . .| |.|..|||.. .|| . | | | . || |....|.
livVrhGetefnkekilqgqtdtpLsekGveQakrvakrLs..nekiny.ifsSdllRAkqTaeiilkalkekkreaverdkrLrEreyGvyeGvaldel
EkeypEDFKARDnDKYEYRYRGGESYRDVVIRLEPVIMELERQ
. |. ||. . . |||| . || . . || ..
r....ellkaag.nvpsfvpegGesieqlelrlvaaleelcak
|
|||||||||
subfamily_PGAM_pd | Subfamily PGAM | 229-290 | 9e-11 | 33.5 | In-house | 5-67 (248) | alignment | ||
Range on Protein: 229-290
Range on HMM: 5-67/248.0
LSRHGESIYNVEKKIGG--DSSLSERGFQYAKKLEQLVKESAGEInLTVWTSTLKRTQQTANYL
| ||||| .| |.|. | | .|||.| . |||. ...|.. |. |.||.|||.|||.. .
llRhGeselnkenkfcgwvDakLsekGkeeAkkagkalkqanlef.divytSvlkRaqqTlevi
|