Gene PMU1 in Saccharomyces cerevisiae

Synonym: YKL128C, PMU1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily HP1-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP040_AA protein Get Run
ScerP040_AA_50-283 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0037864 Phosphoglycerate mutase-like 51-281 1.8e-19 62.5 In-house 5-195 (211) alignment 
Range on Protein: 51-281
Range on HMM: 5-195/211.0
RHYKLLILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVLLPmakqlGMLPHVFFSSPMRRCLETFIESWTPVlae
 ... |.| |||. ..||. . .|                  |||. ||.||. |.|..|  .        |. .....|||..|...|    .  .   
llmtrlyLvRHGetewnaegrlqg..................wldvpLtelGreqaralgealadl.....glpfdavysSpllRaiqTaeiileal...

tqelpaG-TKISTRIIEGLREtlgshtCDKRVAHSMAVDEYQDFSTESGHTVHWQY----VPDYpeddelwlpdhrETCAEMDKRTLNGLFELFNQLSSE
      |  ... .. ..|||      .|  . . . ..| ...  |  .  .. .     |.             |. |.. .| |. | ||...| ..
......glpllpvevdprlrE......rdfgalegltleeiaekypeelvawlrdpydfrppgg............EsladvvaRvlpaleellarllkd

EKFISLTCHSGVIQSVLRNLQH-----PPIYNLDTGKVVAV
.. . . .|.||. ..|. | .      . .||..| |. .
genvlvVsHggvlrallayllglsleellrlnlpngsvtvl
subfamily_PMU1_pd Subfamily PMU1 52-284 4.9e-147 477.8 In-house 1-233 (233) alignment 
Range on Protein: 52-284
Range on HMM: 1-233/233.0
HYKLLILARHGQGYHNAAILRYGMEKWDAYWSLLSGDEHGEWLDSKLTPLGKDQVRRTGSNVLLPMAKQLGMLPHVFFSSPMRRCLETFIESWTPVLAET
|||||||.|||.||||.|||.|||||.||||.||||||.||.||||||.||||||||||||||||||||||||.||||||..||.|||..||...|||||
hykllilvrhGeGyhnlailkyGmekldaywallsgdengeildskltslGkdqvrrtGsnvllpmakqlGmlehvffsstlrraletalesfeavlaet

QELPAGTKISTRIIEGLRETLGSHTCDKRVAHSMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELFNQLSSEEKFISL
||||||||.||||||.|||||||||||||||.|..||||||.|.|||||||||||||.|||||||..|||||..|.|||||..||||...|||||||..|
qelpagtkvstriieslretlGshtcdkrvarsaivdeyqdlslesghtvhwqyvPdlPeddelwktdhretkveldkrtlatlfelaadlsseekfval

TCHSGVIQSVLRNLQHPPIYNLDTGKVVAVVVE
..||.|..|.||.|.|..|||||||||||.|.|
vthssvllsllraldhlriynldtGkvvalvle
0047369 Phosphoglycerate mutase-like 53-268 4.9e-06 19.1 In-house 45-346 (438) alignment 
Range on Protein: 53-268
Range on HMM: 45-346/438.0
YKLLILARHGQGYHNAA-----------ILRYGMEKWDAY-------WSLLSGDehgewldskLTPLGKDQVRRTGSNVL-----LpmakqlgmLPH---
 .. .|.|||  . .             .. ..  ... .       ...  |.         |||||..|..  |         |         |.   
kqvqvlfRHGaRtPtksklkkleplwellenattypsgplsflndwlgpcgagq.........LTplGreqayelGkrlrkrYglL........npedvl

VFFSSPMRRCLETFIE------------SWTPVLAEtqelPAGTKISTRIIEGLRETLGSHTCDKR---VAHSMAVDEYQDFSTESGHTVHWQYVP--DY
...||...|.|..               ...| | .    |.   .  .  . |  .|.| .|...   .   .| ||.... ...   .  .. |  ..
yvrssdvdRtlqSAqaflaGlfppegtgelapilwq....pipihtipesddfllnllpsdscpafdellkeflasdeflelllkdilkrlkkllpglnl

PEDDELWLPDH--RETCAEMD-------------KRTLNGLF---------------------------ELFNQLSS----------------------E
. .| |.| |.   .|.| ..             .  |. |                            |... | .                      .
tpsdvldlydlcaydtlangyaglplspfcslftpeelevleyladlefyylygygnelaklaggpllneilarledaingkstnlnltldsngvtfPld

EKFISLTCHSGVIQSVLRNLQHP
 |..   .| . |...|  |.  
lklylyfaHdttiaallsaLglf
0051064 Phosphoglycerate mutase-like 54-279 3.2e-25 81.9 In-house 4-214 (241) alignment 
Range on Protein: 54-279
Range on HMM: 4-214/241.0
KLLILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVllpmaKQLGMLPHVFFSSPMRRCLETFieswTPVLAETqE
| |.| |||. ..||. . .|                  | |. ||.||. |.|..|        ..||. . ...|||..|...|      .....   
krlyLvRHGesewnaegrlqg..................wtDvpLtelGreqaralgerl.....adlgikfdavysSpllRaiqTa....eiiaeal.g

LPagtKISTRIIEGLRETlgSHTCDKRVAHSMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLP-------------DHRETCAEMDKRTLNGLFELFN
||   ..  .. ..|||   .. .. .  ...  ......     ..  . . | .  .|.|.|                 |. |.. .| |. | ||..
lp...llpvvvdprlrEi..dfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleella

QLSSEEKFISLTCHSGVIQSVLRNLQHPP-----IYNLDTGKVV
.|  ..| . . .|.||| ..|. | . |      .||..| |.
rllldgknvlvVsHggvirallayllglpleellrlnlpngsvt
0043909 Phosphoglycerate mutase-like 54-283 4e-24 77.9 In-house 3-221 (249) alignment 
Range on Protein: 54-283
Range on HMM: 3-221/249.0
KLLILARHGQGYHNAAilrygmekwdaywsllsgDEHGEWLDSKLTPLGKDQVRRTGSNVllpmaKQLGMLPHVFFSSPMRRCLETfiesWTPVLAETQE
| |.| |||. ..||.                  . .  |||| ||.||. |.|..|  .     |.||. .....|||..|...|    . ..|.| . 
krlyLvRHGetewnae..................grfqgwlDspLtelGreqaralgeal.....kelgipfdavysSplkRAiqT....aeiileelgl

LPagtkISTRIIEGLRET-LGSHT-CDKRVAHSMAVDEYQDFST----------ESGHTVHWQYVPDYPE---DDELWLPDHRETCAEMDKRTLNGLFEL
      .  .. ..|||  .|. . ..|  ....  .|.. . .          |. .........||     |..|. | . |. |.. .| |..| ||
dk....lpvevdprLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleel

FNQLSSEEKFISLTCHSGVIQSVLRNLQHPPIY-----NLDTGKVVAVVV
...|. ... . . .|.||. ..|. | . ..      ||..| .. ...
larllkdggnvliVaHggvlrallayllglsledilrlnlpngsitvlel
0049178 Phosphoglycerate mutase-like 54-283 2.1e-22 72.4 In-house 4-216 (243) alignment 
Range on Protein: 54-283
Range on HMM: 4-216/243.0
KLLILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVllpmaKQLGMLPHVFFSSPMRRCLETFieswtpvlaetQE
. |.| |||. ..||. . .|                  |.|| ||.||. |.|..|        ..||. . ...|||..|...|            . 
trlyLvRHGetewnaegrlqg..................wtDspLtelGreqAralgell.....aelglkfdavysSplkRaiqTa...........ei

LP------AgtkISTRIIEGLREtLGSHTCDKRVAHSMAV---DEYQDFSTESGHTVH---WQYVPDYPEDDELWLP----DHRETCAEMDKRTLNGLFE
.           .  .. ..||| .. .... .  . .|    .|.. . . . ...    . . . .|. |.|...       |. |.. .| |. | |
ilealglpl...lpvvvdprLrE.rdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpalee

LFNQLSSEEKFISLTCHSGVIQSVLRNLQHPPIY-----NLDTGKVVAVVV
|...|. ..| . . .|.||| ..|. | . |.      ||..| |. . .
llaellhdgktvlvVaHggvirallalllglpleellrlnlpngsvtvlel
0036777 Phosphoglycerate mutase-like 54-282 7.5e-22 70.6 In-house 3-216 (247) alignment 
Range on Protein: 54-282
Range on HMM: 3-216/247.0
KLLILARHGQGYHNAailrygmekwdaywsllsGDEHGEWLDSKLTPLGKDQVRRTGSNVllpmaKQLGMLPHVFFSSPMRRCLETfiesWTPVLAETqe
| |.| |||. ..||                   . .  |||. ||.||. | ...|  .     |.||. . ...|||..|...|    . ..|..   
krlyLvRHGetewna..................egrfqgwlDvpLtelGreqakalgell.....kelglpfdavysSpllRAiqT....aeiileal..

lpA-GtKISTRIIEGLREtLGSHTCDKRvAHSMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLP-------------DHRETCAEMDKRTLNGLFELF
      ..  .. ..||| .. .... .  .. . ..|...     .  .. . | . ...||.|               . |. |.. .| |. | ||.
..gls.llpvvvdprLrE.rdyGalegl.tkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleell

NQLSSEEKFISLTCHSGVIQSVLRNLQHPPIY-----NLDTGKVVAVV
..|  ... . . .|.||. ..|. | . ..      ||..| .. ..
arllkdgenvlvVsHggvlrallayllglsledilrlnlpngsitvle
0049059 Phosphoglycerate mutase-like 54-267 2e-06 20.1 In-house 45-343 (435) alignment 
Range on Protein: 54-267
Range on HMM: 45-343/435.0
KLLILARHGQ----------------------GYHNaailrygmekwdaywsllsgDEHGEWLD-------SKLTPLGKDQVRRTGSNVL-----LpMAK
.. .|.|||                        |.|                    ...... |       . |||||..| ...|         | . .
qvqvlfRHGaRtPtsklikklealwekllslltypn....................gplsflndwnyplgageLTplGreqayelGkrlrkrYgfL.ynp

QlgmlPHVFFSSPMRRCLETFIESWTPVLAET-------QELPAGTKISTRIIEGLRETLGSHTCDKRVAHS---MAVDEYQDFSTESGHTVHWQYVPDY
.     ....||...|.|..        . .        . |.  . . ..  . .. || . .|.. .  .   .| ||.... .|.   .  .. | .
d....evyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdndtlpydscpafdellkellasdeflelflerilkllqellpgl

P--EDDELWLPDH---------------RETCAEMDKRTLNGLF---------------------------ELFNQLSS---------------------
    .| |.|.|                   |  ...  |. |.                           |....| .                     
gltpsdvldlydlckydtlllgyahglplpfcslfteeelevleyladlefyylygygdeiaklaggpllneilarledaingdstnlnltldsnpatfp

-EEKFISLTCHSGVIQSVLRNLQH
 . |..   .| . |...|  |. 
ldlklylyfaHdttiapllsaLgl
0036887 Phosphoglycerate mutase-like 55-279 1.9e-19 62.5 In-house 3-181 (202) alignment 
Range on Protein: 55-279
Range on HMM: 3-181/202.0
LLILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVLlpmakqlGMLPHVFFSSPMRRCLETFIESWTPVlaetqel
 |.| |||. ..|.. . .|                  .||. ||.||. |.|..|  ..       |. . ...|||..|...|    .          
rlyLvRHGetewnvegrlqg..................dldvpLtelGreqaralgerla.......glpfdavysSpllRaiqTaeiiaeal.......

pagtKISTRIIEGLRETLGSHTcdkrvahsmavdeyQDFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELFNQLssEEKFISLTCH
    ... .. ..|||   .                .  ..|  .  . ... ..  |.  . | . |. |.. .| |. | ||...|  ... . . .|
....glpvivdprlrEidfgal..............egltleeiaekypeelaawlrdpydfrppggEsladvvaRvlaaleellarl..dggnvlvVsH

SGVIQSVLRNLQHPPIYN------LDTGKVV
.||.  .|. | . .. .      |..| |.
ggvlrallayllglsledllrlrklpngsvt
0053607 Phosphoglycerate mutase-like 55-279 2.8e-14 45.6 In-house 3-173 (191) alignment 
Range on Protein: 55-279
Range on HMM: 3-173/191.0
LLILARHGQGYHNAAilrygmekwdaywS---LlsgdehgewlDSKLTPLGKDQVRRTGSNVLLPmakqlGMLPHVFFSSPMRRCLETFIESwtpvlaet
 |.| |||. ..||.                            |. ||.||. |.|...           |. . ...|||..|...|            
rlyLvRHGetewnae.............grlqg..........dvpLtelGreqaralaellael.....glkfdavysSpllRarqTaeii........

qelpagtKISTRIIEGLRETLGSHTcdkrvahsmavdeyQDFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELFNqlsseEKFISL
       ... .. ..|||                    .  . |  .  .....  . .|.  . |.. |. |.. .|.|. | ||..     .. . .
.......glpvevdprlrEidfgdw..............egltleelaekypeelaawlrdpldyrppggEsladvaaRvlpaleella.....ggnvlv

TCHSGVIQSVLRNLQHPPIY-----NLDTGKVV
 .|.|||. .|. | . |.      ||..| |.
VaHggvirallayllglpleellrlnlpngsvt
0048439 Phosphoglycerate mutase-like 55-142 9.9e-06 18.2 In-house 12-101 (391) alignment 
Range on Protein: 55-142
Range on HMM: 12-101/391.0
LLILARHG------------QGYHNAailrygmekwdaywsllsGDEHGEWLDSKLTPLGKDQVRRTGSNVLLPMAKqLGMLPH---------VFFSSPM
. .|.|||            ....|                      .|.. .. |||||..|.. .|        . ||.||           ..||..
vqvlfRHGaRtPtssypnkldpllnk..................llpngpcglgeLTplGreqlyelGrrlrkrYvd.lgllpskytlnpsevyvrssdv

RRCLETFIE
.|.|..   
dRtlqSAqa
0048955 Phosphoglycerate mutase-like 56-277 1.2e-25 83.2 In-house 3-209 (240) alignment 
Range on Protein: 56-277
Range on HMM: 3-209/240.0
LILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVLLPmakqlGMLPHVFFSSPMRRCLETFIESWTPVlaetqelp
|.| |||. ..||. . .|                  | |. ||.||. |.|..|           |. . ...|||..|...|    .           
lyLvRHGesewnaegrlqg..................wtDvpLtelGreqaralgerLadl.....gikfdlvysSpllRaiqTaeiiaeal........

aG--TkISTRIIEGLRETlgSHTCDKRVAHSMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLP-------------DHRETCAEMDKRTLNGLFELFN
 |  . .  .. ..|||   .. .. .  ...  ......     .. .. ..| .  .|||.|               . |. |.. .| |. | ||..
.glpl.lpvvvdprlrEr..dfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleella

QLSSEEKFISLTCHSGVIQSVLRNLQHPPIYN-----LDTGK
.   ..| . . .|.||| ..|. | . |.       ...| 
ralkpgknvlvVsHggvirallayllglpleeilrlnipngs
His_Phos_1 Histidine phosphatase superfamily (branch 1) 56-260 7.8e-20 64.4 Pfam-A 2-157 (158) alignment 
Range on Protein: 56-260
Range on HMM: 2-157/158.0
LILARHGQGYHNAAILrygmekwdaywsllsgdeHGEWLDSKLTPLGKDQVRRTGSNvllpmAKQLGMLPHVFFSSPMRRCLETfiesWTPVLAETQelp
|.|.|||. ..|..                    . .| |..||. |..|.|..|        |. .  ......||..|...|    ....|.| .   
lylvRHGesewnkegr..................lqgwsdvpLtekGreqarelgkk.....LkradlpidavytSplkRaiqT....aeilleeld...

agtkISTRIIEGLRETLGsHTCD---KRVAHSMAVDEYQDFSTesghtVHWQYVPDypeddelwlpdHRETCAEMDKRTLNGLFELFNqLSSEEKFISLT
    | ... ..|||     ...   |. ....  .||. . .      .... |.           . |. |.. .|. . | ||..   .... . ..
....ipiikeprLrerdf.geweglpkeevkeefpeeyekwkr.....dkkefrpp...........egesladvyeRvapfleelie.akdkgenvliv

CHSGVIQS
.| ||...
sHggvlra
His_Phos_1 Histidine phosphatase superfamily (branch 1) 56-260 7.8e-20 64.4 In-house 2-157 (158) alignment 
Range on Protein: 56-260
Range on HMM: 2-157/158.0
LILARHGQGYHNAAILrygmekwdaywsllsgdeHGEWLDSKLTPLGKDQVRRTGSNvllpmAKQLGMLPHVFFSSPMRRCLETfiesWTPVLAETQelp
|.|.|||. ..|..                    . .| |..||. |..|.|..|        |. .  ......||..|...|    ....|.| .   
lylvRHGesewnkegr..................lqgwsdvpLtekGreqarelgkk.....LkradlpidavytSplkRaiqT....aeilleeld...

agtkISTRIIEGLRETLGsHTCD---KRVAHSMAVDEYQDFSTesghtVHWQYVPDypeddelwlpdHRETCAEMDKRTLNGLFELFNqLSSEEKFISLT
    | ... ..|||     ...   |. ....  .||. . .      .... |.           . |. |.. .|. . | ||..   .... . ..
....ipiikeprLrerdf.geweglpkeevkeefpeeyekwkr.....dkkefrpp...........egesladvyeRvapfleelie.akdkgenvliv

CHSGVIQS
.| ||...
sHggvlra
0039931 Phosphoglycerate mutase-like 56-281 2.9e-16 52.0 In-house 2-173 (219) alignment 
Range on Protein: 56-281
Range on HMM: 2-173/219.0
LILARHGQGYHNAailrygmekwdaywsllSGDEHGewlDSKLTPLGKDQVRRTGSNVllpmaKQLGMLPHVFFSSPMRRCLETFIESwtpvlaetqelp
|.| |||. ..|.                  |   |   || ||..|. |.|..|        |.||. . ...|||..|...|                
lyLvRHGetewnv.................egrlqg...dspLterGreqaralgerl.....kdlglpfdavysSpllRaiqTaeii............

agtKISTRIIEGLREtlgshtcdkrvahsMAVDEYQDFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELFNqlsseEKFISLTCHS
   ... .| ..|||              .    ... . |  .  . . .  . .|.  . |.. |. |.. .| |. | ||..     .. . . .|.
...glpveidprLrE..............idfgdlegltleeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleella.....genvlvVsHg

GVIQSVLRNLQH-----PPIYNLDTGKVVAV
|||. .|. | .      . .||..| |. .
gvirallayllglsleeilrlnlpngsvtvl
0035570 Phosphoglycerate mutase-like 56-282 3e-16 52.0 In-house 2-174 (219) alignment 
Range on Protein: 56-282
Range on HMM: 2-174/219.0
LILARHGQGYHNAailrygmekwdaywsllSGDEHGewlDSKLTPLGKDQVRRTGsnvllPMAKQLGMLPHVFFSSPMRRCLETFIESwtpvlaetqelp
|.| |||. ..|.                 .|   |   |. ||..|. | |..|        ..||. . ...|||..|...|                
lyLvRHGetewnl.................egrlqg...dvpLterGreqaralg.....ealadlgipfdavysSpllRaiqTaeii............

agtKISTRIIEGLRETLGSHTCDkrvahsmavdeyqdFSTESGHTVHWQYVPDYPEDDELWLPDHRETCAEMDKRTLNGLFELfnqlsSEEKFISLTCHS
   ... .| ..|||    .  .               ...  .. . ..   . .|.  . | . |. |.. .| |. | ||      ... . . .|.
...glpveidprLrEidfgdleg..............ltldeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleel.....edgenvlvVsHg

GVIQSVLRNLQHPPIY-----NLDTGKVVAVV
|||. .|. | . |.      ||..| |. . 
gvirallayllglpleeilrlnlpngsvtvle
0050036 Phosphoglycerate mutase-like 56-270 6.5e-12 37.7 In-house 3-149 (171) alignment 
Range on Protein: 56-270
Range on HMM: 3-149/171.0
LILARHGQGYHNAAILRYGmekwdaywsllsgdehgeWLDSKLTPLGKDQVRRTGSNVllpmakqlgmLPHVFFSSPMRRCLETFIESWtpvlaetqelp
|.| |||. ..|.. . .|                  |.|. ||.||. |.|..|              .....|||..|. .|    .           
lyLvRHGetewnlegrfqg..................wtdvpLtelgraqaralgell..........pfdavysSpllRArqTaelil...........

agtkISTRIIEGLRETLGSHTCDKRVAHSMAVDEYqdfstesghtvhwqyvpdYPEDDELWLPDHRETCAEMDKRTLNGLFELFnqlsseeKFISLTCHS
    .. .. ..|||        ....  .|   .                  .  |.  . |   |. |.. .| |. | ||        . . . .|.
....lpvivdprLrErdfGawegltldeiaakype..................wlldlldlappggEsladvlaRvlpaleell.......gnvlvvaHg

GVIQSVLRNLQHPPI
||| ..|. | . ..
gvirallalllglsl
subfamily_STS_pd Subfamily STS 95-266 8e-06 17.4 In-house 52-198 (245) alignment 
Range on Protein: 95-266
Range on HMM: 52-198/245.0
DSKLTPLGKDQVRRTGSNVLlpmakQLGMLPHVFFSSPMRRCLETFieswTPVLAETQelpagTKISTRIIEGLRETLgsHTCDKRVAHSMAVDEYQDFs
|. ||  |. | . .| . |     . |. ... |.||. ||..|     ...| ...      ||  .. .|| | |  . ..| . . .  .| . | 
DpPlterGviqAkllgraLl.....eagikiehifcSPslrciqTa....aailkglg.....kkikikvepgllewl..kldrkpipellspeelkkf.

tesGHTVHWQYVPDYPEDDELWlpdhRETCAEMDKRTLNGLFELFNQLsSEEKFISLTCHSGVIQSVLRNLQ
   .  .  .| |  .  .        |.. |. .|. . . |....  .|.. | .  |   .... |.|.
...fpqidedYkpvlslselks....keseeelyeRikkvvkeiiekv.pedgniliVahaatldalsrqll