Gene YLR345W in Saccharomyces cerevisiae

Synonym: YLR345W, YLR345W

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP1
Subfamily PFKFB
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP047_AA protein Get Run
ScerP047_AA_284-505 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
6PF2K 6-phosphofructo-2-kinase 73-290 3.5e-82 265.1 Pfam-A 3-222 (223) alignment 
Range on Protein: 73-290
Range on HMM: 3-222/223.0
TDSGNLFHAGRILVVLVGLPATSKTLLSVAITRYTRWLGVRTKSFHFSEYKESAKNIPSDYFCVVPTSKEGVAFVEKLRMQMLNDILAFFNDLSGQLAIY
..... ... ....|||||||..||..| ..|||..|||||||.|....|...|.. .||. .. |...|.... |||....|.|.|...|. .||.||.
qstvknlknsklvivlvGLpargKtyiskkltrylkwlgvrtkvFnvgkyrreavkalsdaeffrpdneealklreklalaalkdllkylneeegqvaif

DALNIRKIDRKNLETTFSEIGVKVLFIESIVSDQEIMNRNIALALES-NDYKGLSTDEAIDEYMRRLSVNEPYYEMMT--HDEELSYIKYINlGKQIIVK
||.|... .||.. ....|...||||.||..||.||...||... .| .|||. .|.|||.....||...| .||...  .||||||||.|.  .. .|.
DAtNttrerRklilefveennlkvlflesvcsdeeiikeNikevklsspDYkdketeeaikdflkRlenyekqyeplddeedeelsyIkvid.vgkslvv

DNIHGYLVNKIVFFLMNLRQK
.|..||| ..||..|.|...|
nnvqgylqsrivyyllNihlk
0037864 Phosphoglycerate mutase-like 285-504 2.4e-28 91.4 In-house 1-208 (211) alignment 
Range on Protein: 285-504
Range on HMM: 1-208/211.0
MNLRQKKGCVYFARCGTSDK--DNY---IHDEELNEEGIHYSQVLKDFVLQR-IKQKRqakknsdslvevidgshdedlktsliVWTGPRKRTHDTALFF
|.|. .   .|. | | ..   ...    .| .|.|.|... . | ... .. ..  .                          |.. | .|...|| ..
MslnllmtrlyLvRHGetewnaegrlqgwldvpLtelGreqaralgealadlglpfda..........................vysSpllRaiqTaeii

SKE-G---IKVQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEMEHTS----KDILIIAHESTLRVLYGYL
 .. |   ..|..  .|| .. |.  .|| ..|..|.| |.   | |||.||.| .||..|.. |..|.| |. ..     ...|...|  .||.|. ||
lealglpllpvevdprlrErdfgalegltleeiaekypeelvawlrdpydfrppggEsladvvaRvlpaleellarllkdgenvlvVsHggvlrallayl

MACTCVELPNLNFTRDKLVEISFSPFCNTVELLN
. ..  ||..||.    .. . ...   ....||
lglsleellrlnlpngsvtvlelddggwvlvsln
subfamily_PFKFB_pd Subfamily PFKFB 286-506 5.4e-66 213.8 In-house 1-196 (198) alignment 
Range on Protein: 286-506
Range on HMM: 1-196/198.0
NLRQKKGCVYFARCGTSDKDNYIH---DEELNEEGIHYSQVLKDFVLQrikqkrqakknsdslvevidgshdEDLKtSLIVWTGPRKRTHDTALFFskeG
|...|. ..|..|.|.|.|... .   |.||.|.|..|...|..|. .                        |.|| .|.|||. .|||..|| ..   |
nihlkpreiylvRhGeseknkkgriggdseLterGveyakklakfike........................enlk.elrvwtselkrtiqTaell...g

IKVQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEMEHTSKDILIIAHESTLRVLYGYLMACTCVELPNLN
....|...|..|. |....||...|..|||.|.||. || |..|.||.|||.||. |.||..||.|......|||||...||||..||..... |||.|.
lpkeqwkaLdeldaGkcdgltyeeikekfpeefkerkkdkyryryprgEsyedlvqRlepvileLereqenvliiaHqavlrvllaylldksaeelpylk

FTRDKLVEISFSPFCNTVELLNIP
.................||||...
vplhtvikltpvaYgckvellkld
0039931 Phosphoglycerate mutase-like 294-505 2.7e-34 110.8 In-house 2-187 (219) alignment 
Range on Protein: 294-505
Range on HMM: 2-187/219.0
VYFARCGTSD---KDNYIHDEELNEEGIHYSQVLKDFVLQRIKQKrqakknsdslvevidgshdedlktsLIVWTGPRKRTHDTALFFskeGIKVQQRSE
.|. | | ..   .. . .| .|.|.|..... | ..  ..  .                           .|.. | .|...|| ..   |..|.. ..
lyLvRHGetewnvegrlqgdspLterGreqaralgerlkdlglpf.........................davysSpllRaiqTaeii...glpveidpr

LRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEMEHtSKDILIIAHESTLRVLYGYLMACTCVELPNLNFTRDKLVE
|| .. |.  .|| ..|..|.| |.   |.|||..|.|..||..|.. |..|.| |...  ...|...|  ..|.|. ||. ... |...||.    ...
LrEidfgdlegltleeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleella.genvlvVsHggvirallayllglsleeilrlnlpngsvtv

ISFSPFCNTVELLNI
.....  ....|||.
lelddggwvlvllnl
0035570 Phosphoglycerate mutase-like 294-503 6.4e-34 109.7 In-house 2-185 (219) alignment 
Range on Protein: 294-503
Range on HMM: 2-185/219.0
VYFARCGTSD---KDNYIHDEELNEEGIHYSQVLKDFVLQRIkqkrqakknsdslvevidgshdedlKTSLIVWTGPRKRTHDTALFFskeGIKVQQRSE
.|. | | ..   .. . .| .|.|.|. ... | ..  ..                           .  .|.. | .|...|| ..   |..|..  .
lyLvRHGetewnlegrlqgdvpLterGreqaralgealadlg.........................ipfdavysSpllRaiqTaeii...glpveidpr

LRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEMeHTSKDILIIAHESTLRVLYGYLMACTCVELPNLNFTRDKLVE
|| .. |.  .|| ..|..|.| |..  | |||..|.|..||..|.. |..|.| |. .  ...|...|  ..|.|. ||. ... |...||.  . .. 
LrEidfgdlegltldeiaekypeelaawlrdpydyrppggEsladvvaRvlpaleel.edgenvlvVsHggvirallayllglpleeilrlnlpngsvtv

ISFSPFCNTVELL
... .  ....|.
leldggggkwvlv
0053607 Phosphoglycerate mutase-like 294-504 1.4e-29 95.4 In-house 4-188 (191) alignment 
Range on Protein: 294-504
Range on HMM: 4-188/191.0
VYFARCGTSD---KDNYIHDEELNEEGIHYSQVLKDFVLQRiK-QK-RqakknsdslvevidgshdedlktsliVWTGPRKRTHDTALFFskeGIKVQQR
.|. | | ..   .. . .| .|.|.|. . . | ..  ..   .  .                          |.. | .|...|| ..   |..|.. 
lyLvRHGetewnaegrlqgdvpLtelGreqaralaellael.glkfda..........................vysSpllRarqTaeii...glpvevd

SELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEMEHtSKDILIIAHESTLRVLYGYLMACTCVELPNLNFTRDKL
..|| .. |    || .....|.| |.   |.||...|.|..||..|.| |..|.| |. .  ...|..||  ..|.|. ||. ... ||..||.    .
prlrEidfgdwegltleelaekypeelaawlrdpldyrppggEsladvaaRvlpaleella.ggnvlvVaHggvirallayllglpleellrlnlpngsv

VEISFSPFCNTVELLN
.......   ...|||
tvlelddggwvlvlln
0036887 Phosphoglycerate mutase-like 294-505 1.9e-29 95.1 In-house 4-197 (202) alignment 
Range on Protein: 294-505
Range on HMM: 4-197/202.0
VYFARCGTSDK--DN-Y--IHDEELNEEGIHYSQVLKDFVLQRikqkrqakknsdslvevidgshdedlkTSLIVWTGPRKRTHDTALFFSKE-GIKVQQ
.|. | | ..   .. .   .| .|.|.|. . . | ......                           .  .|.. | .|...|| ..... |..|..
lyLvRHGetewnvegrlqgdldvpLtelGreqaralgerlagl...........................pfdavysSpllRaiqTaeiiaealglpviv

RSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEMEHT--SKDILIIAHESTLRVLYGYLMACTCVELPNLN-FT
   || .. |.   || ..|..|.| |..  | |||.||.|..||..|.. |....| |. ..  ....|...|  .||.|. ||. ... .|..|. . 
dprlrEidfgalegltleeiaekypeelaawlrdpydfrppggEsladvvaRvlaaleellarldggnvlvVsHggvlrallayllglsledllrlrklp

RDKLVEISFSPFCNTVELLNI
   .. .....   ...|||.
ngsvtvlelddggwvlvllnd
0051064 Phosphoglycerate mutase-like 294-502 6.1e-28 90.8 In-house 6-227 (241) alignment 
Range on Protein: 294-502
Range on HMM: 6-227/241.0
VYFARCGTSDK--DNYI---HDEELNEEGIHYSQVLKDFVLQRIKQKRqakknsdslvevidgshdedlktslIVWTGPRKRTHDTALFFSKE-G---IK
.|. | | |.   .. .   .| .|.|.|. ... | ..  ..  .                           .|.. | .|. .||  . .. |   ..
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerladlgikfd.........................avysSpllRaiqTaeiiaealglpllp

VQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRF-------------------------PRAESYHDLAVRMEPLLLEMEHT----SKDIL
|..  .|| .. |   .|| ..|..||| |.   | ||...|.                         |..||..|.| |..| | |. ..     |..|
vvvdprlrEidfgalegltleeiaekfpeelvawlrdpldvrppllelldlllllldlryagllddllpggEsladvaaRvlpaleellarllldgknvl

IIAHESTLRVLYGYLMACTCVELPNLNFTRDKLVEISFSPFCNTVEL
...|  ..|.|..||. ..  ||..||.    .. . ...  ..| |
vVsHggvirallayllglpleellrlnlpngsvtvleldddgkrvvl
0048955 Phosphoglycerate mutase-like 294-496 3.3e-27 88.3 In-house 3-218 (240) alignment 
Range on Protein: 294-496
Range on HMM: 3-218/240.0
VYFARCGTSDK--DN-YI--HDEELNEEGIHYSQVLKDFVLQRIK--QkrqakknsdslvevidgshdedlktslIVWTGPRKRTHDTALFFSKE-G---
.|. | | |.   .. .   .| .|.|.|. ... | ..  ..    .                           .|.. | .|...||  . .. |   
lyLvRHGesewnaegrlqgwtDvpLtelGreqaralgerLadlgikfd...........................lvysSpllRaiqTaeiiaealglpl

IKVQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRF-------------------------PRAESYHDLAVRMEPLLLEMEH----TSKD
..|..  .|| .. |   .|| ..|..||| |.   | ||...|.                         |..||..|.| |... | |. .    ..|.
lpvvvdprlrErdfgalegltldeiaekfpeelvlwlrdpldvrppllelldellllldlryalldedllpggEsladvaaRvlaaleellaralkpgkn

ILIIAHESTLRVLYGYLMACTCVELPNLNFTRDKLVEISFSPF
.|...|  ..|.|..||. ..  |...||.    .. ..... 
vlvVsHggvirallayllglpleeilrlnipngsvtvlelddg
0049178 Phosphoglycerate mutase-like 294-504 1.2e-24 79.8 In-house 6-227 (243) alignment 
Range on Protein: 294-504
Range on HMM: 6-227/243.0
VYFARCGTSDK--DNYI---HDEELNEEGIHYSQVLKDFVLQRikQ---KrqakknsdslvevidgshdedlktslIVWTGPRKRTHDTALFFSKE-G--
.|. | | ..   ....   .| .|.|.|.   . | ..  ..  .                              .|.. | ||...||  . .. |  
lyLvRHGetewnaegrlqgwtDspLtelGreqAralgellael..glkfd..........................avysSplkRaiqTaeiilealglp

-IKVQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRF-----------------------PRAESYHDLAVRMEPLLLEMEHT----SKDI
 ..|..  .|| .. |.  .|| ..|..|.| |.   . |||..|.                       | .||..|.| |..| | |. ..     |..
llpvvvdprLrErdfGalegltkaeiaakypeelvawwrdpydarppalllldlllplldrlladldllpggEsladvaaRvlpaleellaellhdgktv

LIIAHESTLRVLYGYLMACTCVELPNLNFTRDKLVEISFSPFCNTVELLN
|..||  ..|.|. .|.  .  ||..||.    ........   ... ||
lvVaHggvirallalllglpleellrlnlpngsvtvlelddggwvlvsln
His_Phos_1 Histidine phosphatase superfamily (branch 1) 294-466 5.6e-23 74.6 Pfam-A 2-158 (158) alignment 
Range on Protein: 294-466
Range on HMM: 2-158/158.0
VYFARCGTSD---KDNYIHDEE--LNEEGIHYSQVLKDFvLQRikqkrqakknsdslvevidgshdEDLKTSLiVWTGPRKRTHDTALFFSK-EGIKVQQ
.|..| | |.   ....  ...  |.|.|.   . | .  |.|                       .||. .  |.| | ||...||  ...  .|....
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkk.Lkr.......................adlpida.vytSplkRaiqTaeilleeldipiik

RSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEME---HTSKDILIIAHESTLRVL
  .||... |..  |. ... ..|| ||..  .|...||.|..||..|.. |..|.| |.    ......||..|...||.|
eprLrerdfgeweglpkeevkeefpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
His_Phos_1 Histidine phosphatase superfamily (branch 1) 294-466 5.6e-23 74.6 In-house 2-158 (158) alignment 
Range on Protein: 294-466
Range on HMM: 2-158/158.0
VYFARCGTSD---KDNYIHDEE--LNEEGIHYSQVLKDFvLQRikqkrqakknsdslvevidgshdEDLKTSLiVWTGPRKRTHDTALFFSK-EGIKVQQ
.|..| | |.   ....  ...  |.|.|.   . | .  |.|                       .||. .  |.| | ||...||  ...  .|....
lylvRHGesewnkegrlqgwsdvpLtekGreqarelgkk.Lkr.......................adlpida.vytSplkRaiqTaeilleeldipiik

RSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRFPRAESYHDLAVRMEPLLLEME---HTSKDILIIAHESTLRVL
  .||... |..  |. ... ..|| ||..  .|...||.|..||..|.. |..|.| |.    ......||..|...||.|
eprLrerdfgeweglpkeevkeefpeeyekwkrdkkefrppegesladvyeRvapfleelieakdkgenvlivsHggvlral
0043909 Phosphoglycerate mutase-like 295-504 2.9e-26 84.8 In-house 6-235 (249) alignment 
Range on Protein: 295-504
Range on HMM: 6-235/249.0
YFARCGTSDKDNY-----IHDEELNEEGIHYSQVLKDFVLQRiK---QkrqakknsdslvevidgshdedlktslIVWTGPRKRTHDTALFFSKE-G---
|. | | .. . .     ..| .|.|.|.   . | ... .. .                               .|.. | ||...|| .. .| |   
yLvRHGetewnaegrfqgwlDspLtelGreqaralgealkel.gipfd...........................avysSplkRAiqTaeiileelgldk

IKVQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLK-----------------------------DPYHFRFPRAESYHDLAVRMEPLLLEMEHT---
..|..  .|| .. |.  .|| ..|..|.| |.   |                              ||...|.|..||..|.. |..| | |. ..   
lpvevdprLrErdfGalegltkaeiaekypeelvawlrrsydvlpplleeldelllellldyaladldplldrppggEsladvvaRvlpaleellarllk

-SKDILIIAHESTLRVLYGYLMACTCVELPNLNFTRDKLVEISFSPFCN---TVELLN
  ...||.||  .||.|. ||. ..  ....||.    .. . ...  .   ...|||
dggnvliVaHggvlrallayllglsledilrlnlpngsitvlelddggkpvvvlvlln
0036777 Phosphoglycerate mutase-like 295-497 9.1e-24 76.8 In-house 6-221 (247) alignment 
Range on Protein: 295-497
Range on HMM: 6-221/247.0
YFARCGTSDK--DNY---IHDEELNEEGIHYSQVLKDFVLQRiK---QkrqakknsdslvevidgshdedlktslIVWTGPRKRTHDTALFFSKE-G---
|. | | ..   ...    .| .|.|.|. . . | ... .. .                               .|.. | .|...||  . .. |   
yLvRHGetewnaegrfqgwlDvpLtelGreqakalgellkel.glpfd...........................avysSpllRAiqTaeiilealglsl

IKVQQRSELRQLNPGSIADLTDQQIMDKFPSEYKESLKDPYHFRF-------------------------PRAESYHDLAVRMEPLLLEMEHT----SKD
..|..  .|| .. |.  .|| ..|..|.| |.   . |||..|.                         | .||..|.. |..| | |. ..     ..
lpvvvdprLrErdyGalegltkaeiaekypeelvawwrdpydyrppllelllelllldllryallpldllpggEsladvvaRvlpaleellarllkdgen

ILIIAHESTLRVLYGYLMACTCVELPNLNFTRDKLVEISFSPFC
.|...|  .||.|. ||. ..  ....||.    .. . . .  
vlvVsHggvlrallayllglsledilrlnlpngsitvleldddg
0050036 Phosphoglycerate mutase-like 310-485 1e-18 59.7 In-house 24-159 (171) alignment 
Range on Protein: 310-485
Range on HMM: 24-159/171.0
DEELNEEGIHYSQVLKDFVlqrikqkrqakknsdslvevidgshdedlkTSLIVWTGPRKRTHDTALFFSkegIKVQQRSELRQLNPGSIADLTDQQIMD
| .|.|.|. . . | ..                               .  .|.. | .|...|| ..    ..|..  .|| .. |.   || ..|..
dvpLtelgraqaralgell..............................pfdavysSpllRArqTaelil...lpvivdprLrErdfGawegltldeiaa

KFPSeykeSLKDPYHFRFPRAESYHDLAVRMEPLLLEMEhtsKDILIIAHESTLRVLYGYLMACTCVELPNLNFTR
|.|      |.|......| .||..|.. |. | | |.    ...|..||  ..|.|. .|. ..  |...|..  
kype....wlldlldlappggEsladvlaRvlpaleell...gnvlvvaHggvirallalllglsleeilrlelpn