Gene CNA1 in Saccharomyces cerevisiae

Synonym: YNR032W, PPG1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP050_AA protein Get Run
ScerP050_AA_111-321 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP3C_pd Subfamily PPP3C 46-527 1.5e-235 775.1 In-house 3-452 (452) alignment 
Range on Protein: 46-527
Range on HMM: 3-452/452.0
IASVPAITGKIPSDEEVFDSkTGLPNHSFLREHFFHEGRLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFL
. .||... |  ..|||||. || |....|.|||..||||..|.|.||.....  |.||..||...||||..||||||.||||||||||||||...||||
vkkvplpkskklteeevfde.tgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylfl

GDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKIN
|||||||.||.||..|||.||...  ....|||||||.|||.|||||.|. .||..||||||..||..||||||.|.|..|||||.|||.||..|..|..
GdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkld

RFREIPSRGLMCDLLWADPVENYddardgsEFDQSEDEFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVTGFPSLITMFSAP
||.|.|..|..|||||.||.|.|       . ...|..||||| ||||.....||.|.||..| ||||||||||||||||||.....||||||||.||||
rfkeppasGplcdllWsdPledy.......geekteekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsap

NYLDTYHNKAAVLKYEENVMNIRQFHMSPHPYWLPDFMDVFTWSLPFVGEKVTSMLVSILNICSEQELDPESEPKaaeetvkaranatketgtpsdekaS
||||.|.|||||||||.||||||||..||||||||.|||||||||||||||||.|||.||||||..||. |.| .                        |
nyldvynnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeee........................s

-----SailedETRRKALRNKILAIAKVSRMFSVLREESEKVEYLKTMNAGVLPRGALARGTEGLNETLSTFEKARKEDLINEKLPP
     |     |.|....|||| ||.|..|.|||||||||.|..||....|.||||||..|.|||.|.||.||.|.|.|||||||||
keeses.....ekrkevirnkiraigklarvfsvlreesesvlllkglttgalprgalsegkegleeklssfeeakkldlineklpp
0045823 Metallo-dependent phosphatases 50-545 3.1e-138 454.2 In-house 9-468 (473) alignment 
Range on Protein: 50-545
Range on HMM: 9-468/473.0
PAITGKIPSDEEVFDSKtGLPNHSFLREHFFHEGRLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYV
. ..  ... ...|. . ||.....|.||...||.|..|...|.|.. .  |.||||||.|...|...||||||..|||.|.|  | | |  ..||||.|
lipvlrlltlpllfill.glldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlv

DRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFRE
||| .| |.| .|..||... |....||||||...|. .. |..|.|.||. ..|..... .. |||||. .|....||||.||.|........|.|..|
DrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierple

IPSRGLMCDLLWADPvenydDAR---DgsefdQSEDEFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVTGFPSLITMFSAPN
||. ||..||||.||     .     .      .   | .||.||... |. .| ..||| |||  |.|.|.... ||... ..||.|....|| |||||
ipddgllldllwsdP.....weddgdg.....llrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApn

YLDTYHNKAAVLKYEENVMNIRQFHMSPHPYWLPDFMDVFTWSLPFVGEKVTSMLVSILNICSEQELDPESEPKaaeetvkaranatketgtpsdekass
|.....|.||||...|......||..||||..|| |.|||..||||..||.|..|...|||.|..||.....                            
YcgrggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededil..........................

AILEDETRRKALRNKILAIAKVSRMFSVLREESEKVEYLKTMN-AGVLPRGALARGTEGLnetLSTFEKARKEDLINEKLPPSLSEVEQEKIKYYEKILK
 .|  |.....|||||||. |..|.|||||||||.| .||...  |.||.|.|. |.| |   |...|.|.| ||||||||||| ... |. |..|.| .
glllleallellrnkilalgkllrvfsvlreesesvlllkgltpsgllplgllllgkell...lesleealkldlineklppsllllsleeeksleline
0049330 Metallo-dependent phosphatases 69-379 1.2e-90 296.8 In-house 14-305 (309) alignment 
Range on Protein: 69-379
Range on HMM: 14-305/309.0
LPNHSFLREHFFHEGRLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLN
|.. ..|.|.......||.|.....|.. .  | .|||||.|...|...||||||..|||.|.|  | | |  ..||||.|||| .| |.| .|..||| 
lslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkll

NLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPVENY
  .....||||||. .|. .. |..|.|.||. |....... .. |||||. .|...|||||.||.|..........|..|||  ||.|||||.||.. .
ypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpir

DDardgsefdqsedeFVPNSlRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEEN-VMNI
..             |.||  ||... |.  | ..||| |||  |||.|.|.. ||... ..|      ||| ||||||.....|..|||...|. |...
eg.............fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvfsapnycgrlgnlgavleidedlvisf

RQFHMSPHPYWL
..|...|....|
llfepvplllll
0053225 Metallo-dependent phosphatases 69-372 4.4e-82 268.8 In-house 6-290 (293) alignment 
Range on Protein: 69-372
Range on HMM: 6-290/293.0
LPNHSFLREHFFHEGRLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLN
|.....|.|....  .||.|.....|.. .  |.||||||.|...|...|||||...|||.|.|  | | |  ..||||.|||| .| |.| .|..||| 
lllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkll

NLGRFWMLRGNHECKHLTSYFTFKNEMLHKY-DMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPVEN
  .....||||||...|. .. |..|.|.|| . |..|.... .. |||||| .|....||||.||.| .......|||. .|| .||..|||| || . 
ypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlw

YDDARDGsefdqsedefvpnslRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNnkvtgfPSLITMFSAPNYLDTYHNKAAVLKYEEN-VMN
.. . .                ||... |   | ..|||.|||  |||.|.... ||... .      ..|.| |||||||....|..|||...|. |..
sgwlpsy...............rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgnlgavlaldeglvwg

IRQFHM
. .|..
fklfap
subfamily_PPP5C_pd Subfamily PPP5C 77-377 6.7e-71 231.9 In-house 26-313 (322) alignment 
Range on Protein: 77-377
Range on HMM: 26-313/322.0
EHFFHEGRLSKEQAIKILNMSTVALSKEPNLLKLKAP----ITICGDIHGQYYDLLKLFEVGGDPAE-IDYLFLGDYVDRGAFSFECLIYLYSLKLNNLG
|.| .. .| |  |.||| ...  |.|.| |.... .    .|.|||||||.|||| .||. | |.|   ||| ||.||||.||.|... |...||    
elfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPn

RFWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGIS-PELKSVEDVNKINRFREIPSRGLMCDLLWADPVENydd
.|.. ||||| ...   . |..|. .||  .|.|   ..|| |||| ..| ... ||||.   .  ...|. ||.|... |. ||...|||.|| |.   
hfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea...

arDGSEfdqsedefvpNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKY--EENVMNIR
   |            .| || ...|    . |||| |.|  |||.|| .. ||.. .. |      |||.|||||| |.  ||.|...   ... ....
..nGrs..........pskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfk

QFHMSPHPY
.|.  .|| 
tfeavehpd
subfamily_PPP7C_pd Subfamily PPP7C 79-365 3.8e-36 117.6 In-house 27-326 (383) alignment 
Range on Protein: 79-365
Range on HMM: 27-326/383.0
FFHEGRLSKEQAIKILNMSTVALSKEPNLLKLKA----PITICGDIHGQYYDLLKLFEVGGDPA-EIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRF
| .. .|  .  ..||  .   | . ||. ....     .|.|||.||.  ||| ..   | |. |  |.| ||.||||  | | |. |..| |     .
fkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkev

WMLRGNHECKHLTSYFTFKNEMLHKY---DMEVYDACCRSFNVLPLAALMNGQYFCVHGGISpELKSVEDVNKINRFREIP--SRGLMCDLLWADPVENY
.. ||||| . |   . | .|. .||   . ..       |  ||||.|.. . . |||||| .  ..| ..||.| .        |  .       |. 
ylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersklvsvlrpplkegeeaekekees

DDARDGSEFDQ----------SEDEFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVtgfpslITMFSAPNYLDTYHNKAAVL
    | .|. |          ...  .||.|||    |    . |.|.  .|  .||.|| .  || . ...||      .|.||| || ..  |. | .
svkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkv......ltifsasnyyeeGsnrGayv

KYEENVM
|  ....
klgkdlt
subfamily_PPP4C_pd Subfamily PPP4C 82-365 4.8e-73 238.9 In-house 12-276 (288) alignment 
Range on Protein: 82-365
Range on HMM: 12-276/288.0
EGRLSKEQAIKILNMS-TVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNH
. .| ||. .| |  .    | .| |. ....|.|.|||||||.||||.||.||||  | .||||||.|||| .| |... | .||.    |  ..||||
rcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnh

ECKHLTSYFTFKNEMLHKYD-MEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPVENyddardgSEFDq
|....|  . | .|.|.||  ..|.  |.. |. |.|||...|. ||||||.||........  |.| .|.|  | .|||||.|| .        . .  
esrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpeda.......egwa.

sedefvpNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVtgfpslITMFSAPNYLDTYHNKAAVLKYEENVM
        | ||  . |  ... .| .||..  |.|||.    ||... |.||      .|..|||||     |.||.|...|.. 
.......vsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekv......ltvwsapnycyrcgnvaaileldeeld
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 82-364 1.7e-44 145.2 In-house 17-282 (307) alignment 
Range on Protein: 82-364
Range on HMM: 17-282/307.0
EGRLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHE
  . .||.  ...  .   .| |  |. .  |  . ||.|||. ||...| . | | |  |.| ||||||| .|.||.. |.. |.       .||||||
kiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhe

CKHLTSYFTFKNEML---HKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPvenyddarDGSEFD
  ..   ..| .| .    |   |..    | || ||..||.  . .|.|||.|| |  .... .  .    | ||.. |.|||||        | | |.
iarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp........dpsvfe

QSedefvpNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENV
         | ||  |.|  .      |  |.  |||||.    || .    |      |||.|||| | . |.|  .||| .| .
wk......assrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrk......litifsapmycnfyknagcvlkvdetl
subfamily_PPP1C_pd Subfamily PPP1C 84-365 3.1e-82 269.0 In-house 9-270 (282) alignment 
Range on Protein: 84-365
Range on HMM: 9-270/282.0
RLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECK
.|....  ..|...  .| ..| ||.|.||..|.|||||||.|||.||| .| |.| .||||||||||| .| | .. | ..|..   ....||||||..
klkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesa

HLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPvenyDDardgsefdqSEDE
... .. |..|. ..|..... .    ||.||||||.. . .|||||.||||||.|...||.|  |.|..||.|||||.||    |.         .  .
sinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdp....dk.........evlg

FVPNSlRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENVM
.  |. || ||.|  ..  |||. | |  |.|||.  ..||.......      |.|.||||||.....|..|||. .|...
wsend.rGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
subfamily_PPP2C_pd Subfamily PPP2C 84-374 1.2e-70 231.0 In-house 16-287 (290) alignment 
Range on Protein: 84-374
Range on HMM: 16-287/290.0
RLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECK
.|....  .. ..    |||| |. ..|.|.|.|||.|||..|||.|| .||.  . .||||||||||| .| |.. .| .||.    |  .|||||| .
qleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesr

HLTSYFTFKNEMLHKYD-MEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPvenydDARDGseFDqsed
 .|  . | .| | ||   .|.      |..|||.||...| ||.|||.||............|..|.|  | .|||||.||     | |.|  .     
qitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdp.....ddrgg..wg....

efvpNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVtgfpslITMFSAPNYLDTYHNKAAVLKYEENVM-NIRQFHMSP
     | ||. ..|  . | || |.|||  |.|||.    ||..  ...|      .|.||||||     |.||.|. ....  .. ||. .|
....isprgagytfgkdisekfnktngltliarahqlvmegynwshdrnv......vtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 84-375 3e-59 193.6 In-house 7-277 (281) alignment 
Range on Protein: 84-375
Range on HMM: 7-277/281.0
RLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECK
...||. .... .    .|.| .| ....||.. ||.|.|. || .|||. | ..|  ..|||||||||  |.|.|| |..||.    | ..||||||  
qytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheia

HLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPvenyddarD--GSEFDqse
..   . | .|   || .|..    | || ||..||.. .  |.|||.|||| . ... .. .  . . |||. |||||||        |  . |.    
svnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadp........dnkveewk...

defvpNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENVmNIRQFHMSPH
     .| || || |  .   .  |  ..  |||||    .||.. .  |      |||.||.||| . |.| ||||| .|.. .|.   . |.
.....assrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdetl.gislvalvpa
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 84-364 8.7e-55 179.0 In-house 5-290 (302) alignment 
Range on Protein: 84-364
Range on HMM: 5-290/302.0
RLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVG--GDPAE---------IDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGR
 .||.. ...... . .|.|| .| .. .|.|| ||||||. ||....      . |.           ..|||||||||  | ||.  ...||.    .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FWMLRGNHECKHLTSYFTFKNEMLH---K-YDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINR-FREIPSRGLMCDLLWADPVEN
. .||||||.| .   ..|..|.     |   .|...     |  .|||||.  . .|||||||| |.|.||..||.| . |.    |  |||.|||.. 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

yddarDGSEFDQSEDEFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENV
     ..    ... ... | .|| |. |   |  .. |  .|  |.|||    .|.... ..|      |.|.||||.|..   || |||| . | 
.....qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 84-364 1.3e-54 178.5 In-house 6-291 (302) alignment 
Range on Protein: 84-364
Range on HMM: 6-291/302.0
RLSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVG--GDPAE---------IDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGR
 .||.. ...... . .|.|| .| .. .|.|| ||||||. ||....      . |.           ..|||||||||  | ||.  ...||.    .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FWMLRGNHECKHLTSYFTFKNEMLH----KYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINR-FREIPSRGLMCDLLWADPVEN
. .||||||.| .   ..|..|.      |  .|...     |  .|||||.  . .|||||||| |.|.||..||.| . |. .  |  |||.|||.. 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

yddarDGSEFDQSEDEFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENV
     ..    ... ... | .|| |. |   |  .. |  .|  |.|||    .|.... ..|      |.|.||||.|..   || |||| . | 
.....qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnkGavlkvdtng
PPP_3 85-367 3.4e-92 301.3 In-house 2-265 (271) alignment 
Range on Protein: 85-367
Range on HMM: 2-265/271.0
LSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKH
||.... ..... .  |.||.||....||.|.|||||||..|||.||..||...| .|||||||||||..|.|.|..|..||..   ....||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

LTSYFTFKNEML-HKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLwadpvenyddardgSEFDQSEDE
......||.|.| .|.. .||..... |..||||||.......||||.||..||.....|..|..|.|..|...|||                 |....|
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll..............lssdpekee

FVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVtgfpslITMFSAPNYLDTYHNKAAVLKYEENVMNI
.. || ||....|. .....||..| |  ||||||....||......||      .|.||||||.....|..|.|| ||. .. 
glenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkv......vtvfSapnycerasnagailkleealtse
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 85-363 1.7e-65 213.8 In-house 10-271 (287) alignment 
Range on Protein: 85-363
Range on HMM: 10-271/287.0
LSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKH
.| .. ...|.     |   | ||...|||||.||||||. |||..|.  | .....|||||||||||| |.|  ..|.|||.    .  .||||||.|.
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

LTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPS--RGLMCDLLWADPvenyddardgsefDQSED
.   . ||.|. .|.. ..|      |. ||| | .. . .|.||||||.|||..... ... .   .  .||. |||||||             ..  .
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadp.............ekdak

EFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEEN
 | .| .|. |  |  |   ..||  ..  |.|||| .. || .. ...      |.|.|||| |     | .||.. .. 
tfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvvsks
subfamily_PPP6C_pd Subfamily PPP6C 85-365 1.1e-64 211.3 In-house 15-275 (290) alignment 
Range on Protein: 85-365
Range on HMM: 15-275/290.0
LSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKH
|..... |. .. .  |..| |.  ...|.|.|||||||.|||..||  ||.  . .|.||||.|||| .|.| . .| .||..   |  .||||||...
lpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrq

LTSYFTFKNEMLHKYD-MEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPvENYDDardgseFDqsede
.|  . | .| |.||   ...  |.. |..|..||....| .|||||.||..| ..... |.| .||| .| .|||.|.|| |. ..      .      
itqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvet......wa.....

fvpNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENVM
    | ||  . |  | . .|.. | |  |.|||.  . |.. . ..|      |.|..|||||     | |..|. |..  
...vsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaee
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 85-362 2.4e-55 180.6 In-house 16-277 (290) alignment 
Range on Protein: 85-362
Range on HMM: 16-277/290.0
LSKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKH
.| .. ..||.     |   | ||...|||.| ||||||  .||. |.  | | ....||||||||||| |.|  ..|. .|.    .  .||||||...
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

LTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFR--EIPSRGLMCDLLWADPVENYDdardgsefdqseD
.   . ||.|.  | . ...      |. |.| | .. . .|.|||||....| | .. ... |      .||. ||||||| .. |            |
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkd............d

EFVPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEE
 .  |  |. |  |  |.  ..||  .|  |.|||| .. |. .  ..|      |.|.|||| |     |  |...  |
tialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatvse
PPP_1 86-353 3.5e-100 327.6 In-house 2-263 (264) alignment 
Range on Protein: 86-353
Range on HMM: 2-263/264.0
SKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHL
..|..........  |.||.|||.....||.|||||||..||||||.|||...| .||||||||||| .|.|.|..|..|||.   ....||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TSYFTFKNEML-HKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADpvenyddARDGSEFDQSEDEF
|....||.|.| .||..|.|.... .|.|||||||.......||||.||||.......|..|..|.|..| .||||..|       ...  . |....|.
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekd.......vdillsddkeqeea

VPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVTGFPSLITMFSAPNYLDTYHN
|.|| ||....|. ....|||..|.| .||||||....||...|..||....|.............|..
vansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
PP2Ac_SM00156 86-365 5e-93 304.0 In-house 2-261 (271) alignment 
Range on Protein: 86-365
Range on HMM: 2-261/271.0
SKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHL
|||.....|. .   |..|.||....||.|..||||||..|||.|.| .| |.|  |.||||||||| .| |....|..||.    .. .||||||....
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPvenyddardgsefDQSEDEFV
. ...|..|. .||. |.|. . . |..||||||.. ...|.|||.||||.|..|..|..|..|.| .||..||||.||             .|.|..| 
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp.............eqkekgfq

PNSlRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNkvtgfpSLITMFSAPNYLDTYHNKAAVLKYEENVM
|.. ||.|. |. .| ..|||.| |  ||||||..| ||......      .|.|.||||||.| ..|||||||.|.|..
psk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 86-364 2.3e-51 167.8 In-house 24-285 (297) alignment 
Range on Protein: 86-364
Range on HMM: 24-285/297.0
SKEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHL
..|. .|.|...   . .. ......||| .|||||||. |||.||  || |   .||||||||||| || | .. | . |..  | ...|||||||. .
teervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefv

TSYFTFKNEMLHKYD-MEVYDACCRSFNVLPLAALMNGQYFCVHGGISP---ELKSVEDVNKINRFREIpSRGLMCDLLWADPVENYddardgSEfdqse
   . | .|  ..|. . .| |    || |||. |.  . .|.|||.||   .  ... ..||.| .|    .|..|||||||.         |      
nkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisgl......sg.....

deFVPNSlRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENV
  |. |  ||.   |   |  |      |  . |||.  . || ..   |      |.|.|||| |   . | ||..  .|..
..fmenq.rgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrk......lvtifsaphycgqfdncaafmscdekl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 87-365 5.5e-68 222.2 In-house 26-285 (298) alignment 
Range on Protein: 87-365
Range on HMM: 26-285/298.0
KEQAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLT
.|.  |......  ..| . |....|||..|||||||| |||.||. .| | . .||||||||||| ...| .. | . |..   .|..|||||||... 
eedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceain

SYFTFKNEMLHKY-DMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPVENYDDardgsefdqsedeFV
  . |..|. ..| ....| .    ||.|||.||. |. .|.|||.|..|||........|  . ..  |  ||||||| ..  .             . 
rvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenavkg.............wa

PNSlRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENVM
.|| || |. |  ..  ..|.   .  ..|||     || .. ..|      |.|.||||.|.. . | |||.| .|...
ens.rGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 89-372 4e-57 186.7 In-house 28-290 (299) alignment 
Range on Protein: 89-372
Range on HMM: 28-290/299.0
QAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSY
. ... ...  .. ... ||...||| .|||||||| |||..|.. | | ....||||||||||   .| .. |.  |..   ||.||||||||  .   
elqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrv

FTFKNEMLHKYDM-EVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPvenyddardgsefDQSEDEFVPN
. | .|  ..|    .. .   .|...||. |.... .|.|||.||.|.... . ...| .. |.  |  |||||||             |||  .. .|
ygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadp.............dqsvkdwlan

sLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENVMNirQFHM
  || |. |  .   . ..  ..  . |||.  . || .. ..|      |.|.|||| |   . | ||..| .||..    |..
.vrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlvc..tfvv
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 89-375 5.7e-50 163.3 In-house 10-275 (280) alignment 
Range on Protein: 89-375
Range on HMM: 10-275/280.0
QAIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSY
. | |. |    . .| || . .||| . |||| || |. .||.. |   |   .|||||||||    | || |. ||.    | ..||||||   .   
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

FTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPVENyddardGsefdqsEDEFvpNS
. |  |  .|| . ..      || .|...|.. . .|.|||.||||  .. . .| |  |   |||. ||||.|| ..      |      |  |   |
ygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnk......g......egwf..hs

LRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENVMnIRQFHMSPH
.|| |. |      .  |.  .  |||||.  . || |    .      |||.|| |||   . | |||.  . |.  .   .. | 
irgisymfgkgvveqacksleidliirahqvvqdgyemmagrr......litvfsvpnycaqftnaaavvclnanlq.vsfqqlipp
subfamily_PPZ_pd Subfamily PPZ 90-365 2.5e-59 194.2 In-house 30-285 (300) alignment 
Range on Protein: 90-365
Range on HMM: 30-285/300.0
AIKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYF
 ..|   .   .  .|.||.|  .. | ||.|||| |||.||   | |   .|||||||||||  |.| .. |.  |..    |..|||||||  .|  .
ilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrvy

TFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPVENYDdardgsEFDQSEdefvpnsl
 | .|  .. ..... .   .|| |||||.. |. ||||||.|| |.|.... .. |  ..|  ||. ||||.|| .. .      |... |        
gfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssn......ewedne........

RGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNkvtgfpSLITMFSAPNYLDTYHNKAAVLKYEENVM
|| |...   |  |||.  |.  . |||   . || ....       ||.|.||||||   . |  ||.   | ..
rgvsycynkvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvsegll
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 91-365 1e-57 188.8 In-house 14-274 (284) alignment 
Range on Protein: 91-365
Range on HMM: 14-274/284.0
IKILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDP------AEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKH
|..   .  .. ||.  |...||..|.||||||. ||| |... | |       |  ||||||||||| || | .  |...||    .  .|||||| . 
ielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrp

LTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPVENYDdardgsEFDQsedef
.   . | .|  ..|   .|.|   .||..||.|... . .|.||||| .| ......|..|  .||  |...|| |||| .. .       ...     
vnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaeve......gyke.....

vpnSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENVM
   | ||.   |  ||  .|||   |  ..|||.    || .. ..|      |.|.|||| |   ..| ||||. .|...
...sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 92-364 1.1e-51 168.9 In-house 10-264 (284) alignment 
Range on Protein: 92-364
Range on HMM: 10-264/284.0
KILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTF
 .|  .   . |.| |.. ..|| ||||||||. |||.||.  | |   .|||||||||||   .| .. |.. |.    .|.||||||||  .   . |
tllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygf

KNEMLHKYDM-EVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIP-SRGLMCDLLWADPVeNyddardgseFDQSedeFVPNSl
 .|  ..|.   || .    | |.||.||.  . .|.|||.|  |. | ..  |.|  . |    |  |.||.||  |         |..    . ||| 
yeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdpt.n.........fqkg...wnpns.

RGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENV
|| |. |   |  |.|    .  ..|||.  . || .. | .      |.|.|||| |   . | |||.  ..|.
rgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 93-364 4.7e-60 196.1 In-house 14-265 (280) alignment 
Range on Protein: 93-364
Range on HMM: 14-265/280.0
ILNMSTVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFK
...  .  |. .  .....||...|||.|||| |||.||.  . | . .||||||||||| . .| .. | . |.    .| .||||||. ..   . ||
viekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrkygfk

NEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPVENYddarDGseFDqsedefvpNSLRGC
.|. ..|. ..|.     .. |||.||..|. .|.|||.|..|.|..|.... |  . .   |  ||||||| ..      |  .         .. ||.
devkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkv....tg..wa........ensrgv

SFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKYEENV
|  |  .   .. .   .  |.| |.  . || .. ..|      |.|.||||.||. ..|.||||. .|..
svifganvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivderl
subfamily_PPPLV_pd Subfamily PPPLV 97-366 7.4e-52 169.4 In-house 9-281 (290) alignment 
Range on Protein: 97-366
Range on HMM: 9-281/290.0
STVALSKEPNLLKLKAPITICGDIHGQYYDLL----KLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFK
.   | .| .||.||.|. . ||.||.| ||     .|. .| | .  ..|||||||||| ||.| . ||..||.    ....|||||| . ..  ...|
avdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqesieyk

NEMLHKYD---MEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFR-----EIPSRGLMCDLLWADPVENYDDARDGSEfdQSEDEF
 |  .|.     ||..|    |..||||| .. . ||||.||    ..   .  |.        .|    |  |.||.|| |. |..  |      .. |
gegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgel..vlneGf

VPNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVtgfpslITMFSAPNYLDTyHNKAAVLKYEENVMN
|.|. || .  |. .|  .||| |.|  ..||||....|.|. .. ..      .|.||. .|  .  |.||..  ... ..
vdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrl......ltvfsssrycGs.sneaalilvdkkklr
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 97-137 3.3e-10 32.6 In-house 21-61 (317) alignment 
Range on Protein: 97-137
Range on HMM: 21-61/317.0
STVALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDP
.  .. |||  |.|.||.||.||||||. ||| |... | |
arelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_PPG1_pd Subfamily PPG1 99-363 1.7e-68 224.1 In-house 28-285 (300) alignment 
Range on Protein: 99-363
Range on HMM: 28-285/300.0
VALSKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEMLHK
  | || |. ....|.|. ||.|||.||.|..|..||.  . .||||||||||| .| | .. |  |||    |  .|||||| . .|  . | .| |.|
ellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfyteclrk

Y--DMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLWADPVENYDDARDgsEFDQSEDEFVpNSLRGCSFAF
|  .  |..     |. | |||... . .|||||.||. .|..... ..||||.|  | ..||||.|| || . . |  . |.. ..|| .| ||. ...
yggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptld..hpdregqhfv.vsqrgagysy

TFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVTgfpsliTMFSAPNYLDTYHNKAAVLKYEEN
  .   |||. | .  |||||.    ||... .||..      |..|||||     |||..|. .|.
gkdvvekflrnndmnriirahqlcnegyqilfdnkls......tvwsapnycyrcgnkasilelyek
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 102-137 1.4e-07 23.9 In-house 28-63 (339) alignment 
Range on Protein: 102-137
Range on HMM: 28-63/339.0
SKEPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDP
  || .|||.||| . ||||||. ||| .... | |
wsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 107-360 2.7e-50 164.5 In-house 2-242 (263) alignment 
Range on Protein: 107-360
Range on HMM: 2-242/263.0
LLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDM-EVYD
||.|.||| |||| |||| |||..|.  |  .. .||||||||||| .|.| .. |.||||    .. .|||||| | .   . |. |. ....  |||.
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

ACCRS----FNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREI-PSRGLMCDLLWADPVEnydDARdGsefdqsedeFVPNSLRGCSFAFTFKA
.        |. .||.|... . .|.|||||| |||..|.  |    |   .. | |||||||| .   ||. |         | || .|  |  |  | 
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek...dak.g.........fepnkiraisnvfgkke

SCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLITMFSAPNYLDTYHNKAAVLKY
   . |   .  |.|||.  . || .. . .      |||.|||  |     | |||.  
vddlckrldidlivrahqvveygyaffadrr......litvfsasryqielcnyaavvvv
Metallophos Calcineurin-like phosphoesterase 113-320 1.4e-40 132.7 Pfam-A 2-199 (200) alignment 
Range on Protein: 113-320
Range on HMM: 2-199/200.0
PITICGDIHGQYYDL----LKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYL--YSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEML----------
.|...||.||...||    |.|.......    .|||||.||||  | |.| .|  ..|||.  .....||||||.....|.. |..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------HKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVEDVnkinrfreipsrglmcdllwadpvenyddar
                        ............. |. |||.|| .|.....||..|....|..|                                
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

dgsefdqsedefvpnslrgCSFAFTFKASCKFLKANGLLSIIRAHEAQ
                   .|. |  .| .|.|. .|.  ..|.|. .
...................gselfgpdalekllekygvdlvlrGHtHk
PPP_4 114-320 1.8e-71 233.2 In-house 1-197 (197) alignment 
Range on Protein: 114-320
Range on HMM: 1-197/197.0
ITICGDIHGQYYDL-LKLFEVGGDPA-EIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSF
.|..||||||..|| |||...||.|. | .|.|||||||||..|.|.|..|..|||.   ....||||||.|.|.....||.|.|.|.  |........|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIP-SRGLMCDL-LWADPVenyddardgsefdQSE-DefVPNSLRGCSFAFTFKASCKFLKAN
..||||||.......||||.|.||.|......|.|..|.| ......|| ||.||              ...    . || ||....|. .. .|||..|
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr.............eaqeg..lansvrGagllFgpdvtekflekn

GLLSIIRAHEAQ
.| .|||.||..
nlkliirshelk
PPP_5_Dcr2 114-319 4.2e-69 225.5 In-house 1-198 (199) alignment 
Range on Protein: 114-319
Range on HMM: 1-198/199.0
ITICGDIHGQYYDL-LKLFEVGGDPA-EIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEMLHK-YDMEVYDACCRS
.|.|||.|||..|| |.||. ||||. | .|.|||||||||..|.|.|..|..|||.   ....||||||...|.....|..|.|.| .  ..|......
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNVLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIP-SRGLMCDL-LWADPVenyddardgsefDQSEDEFVPnSLRGCSFAFTFKASCKFLKAN
|..||||||.......||||.|||.||.|...||.|..||| ..| ..|| ||.||.            |. |. ... | ||....|. .. .|||. |
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr............daqegckln.seRGagllfgpdvtekflekn

GLLSIIRAHEA
.|  |||.||.
nlkliirshel
PPP_2 114-319 1.2e-68 223.7 In-house 1-197 (198) alignment 
Range on Protein: 114-319
Range on HMM: 1-197/198.0
ITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEML-HKYDMEVYDACCRSFN
.|.|||.|||..|||.||..|....| .|||||||||||..|.|.|..|..|||.   ....||||||.|.......||.|.| .|.. .||..... |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

VLPLAALMNGQYFCVHGGISPELKSVEDVNKINRFREIPSRGLMCDLLwadP--VenyddardgSEFDQSEDEFVPNSLRGCSFAFTFKASCKFLKANGL
.||||||.......||||.|.|.|......|..|..|.|..|...|||   .             . .....|.. || ||....|. ......|..| |
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll...eeek.........lsdpkekeellansarGagllfgpdvteelleknkl

LSIIRAHEA
  ||||||.
kliiRaHev
subfamily_YNL217W_pd Subfamily YNL217W 114-194 3.1e-07 23.1 In-house 12-88 (235) alignment 
Range on Protein: 114-194
Range on HMM: 12-88/235.0
ITICGDIHGQYYDLLKLFE--VGGDPAEIDYLFLGDYVDRGAFSFECLIYLyslklnNLGRFWMLRGNHECKHLTSYFTFKNE
. . ||.|| | .|..|..  .||   ..  ...|| ...|  | | . |.             ..||||   | .|   |..
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 141-365 2.1e-51 168.0 In-house 102-306 (317) alignment 
Range on Protein: 141-365
Range on HMM: 102-306/317.0
DYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVED
 ||||||||||| ||.| .| |..|||    . ..|||||| . .   . | .|. ..|. ..|.|    ||||||.|..| . .|.||||| || ... 
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlkq

VNKINRFREIPSRGLMCDLLWADPVENYDdardgsEFDqsedefvpNSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLIT
..|..|  .||  |...|| |||| .. .       .         .| || .. |  ||  .|||   |  ..|||.    || .... |      |.|
ldklkrpldipdvGvladltwadpdaevk......gyk........esarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvt

MFSAPNYLDTYHNKAAVLKYEENVM
.||||.|    .| ||||. .....
ifsapsycGqldniaavlsvdkklk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 141-363 1.9e-44 145.2 In-house 121-323 (339) alignment 
Range on Protein: 141-363
Range on HMM: 121-323/339.0
DYLFLGDYVDRGAFSFECLIYLYSLKLNNLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISPELKSVED
 ||||||||||| ||.| .| | .|||    | ..|||||| . . . . |  |. ..|| ..|..    |||.|..|..|   .|.|||||  | |...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

VNKINRFREIPSRGLMCDLLWADPvenyddardgsefDQSEDEFVPnSLRGCSFAFTFKASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKvtgfpsLIT
.  ..|  |||  |.. || ||||             | .|  . | | ||.|| |   |   |||   |  .|| |.  . || ..   .      |.|
fsvfkrpleipdvgvltdltwadp.............dptekgykp.sargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvt

MFSAPNYLDTYHNKAAVLKYEEN
.||||||     | |||.  ...
ifsapnycgqndntaavfsidkk