Gene CMP2 in Saccharomyces cerevisiae

Synonym: YLR361C, DCR2

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP3C
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP052_AA protein Get Run
ScerP052_AA_136-363 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP3C_pd Subfamily PPP3C 70-574 2.2e-238 784.5 In-house 1-452 (452) alignment 
Range on Protein: 70-574
Range on HMM: 1-452/452.0
RIMNKVPAITSHVPTDEELFQPNGIPRHEFLRDHFKREGKLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLF
|...|||...|.. |.||.|. .|.|..|.|..||..||.|....|..|.. |..|..||..|..| |||||.||||||..|||||||||||||.|.|||
rvvkkvplpkskklteeevfdetgkpklevlkehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylf

LGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNL
||||||||.||.||..|||.||........||||||||.|||.|||||.|. .||. ..|..|.|||..||||||.|.|.||||||.|||..||.||..|
lGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkl

NRFREIPSHGLMCDLLWADPIEEYdevldkdlteedivnsktmvphhGKMApSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMY
.||.|.|..|..|||||.||.|.|                       |... ....|||||||||||...|.|.|.|||.. ||||||||||||||||||
drfkeppasGplcdllWsdPledy.......................geek.teekfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmy

KNTKTLGFPSLLTLFSAPNYLDTYNNKAAILKYENNVMNIRQFNMTPHPYWLPDFMDVFTWSLPFVGEKVTEMLVAILNICTEDELENDTPVIeelvgtd
......|||||.||||||||||.||||||.||||||||||||||..|||||||.|||||||||||||||||||||.|||||..||||...          
rkseatgfPslitlfsapnyldvynnkaavlkyennvmnirqfnssphpywlpnfmdvftwslpfvgekvtemlvnilnicsddelekeeeee.......

kklpqagkseatpqpatsaspkHASILDDEHRRKALRNKILAVAKVSRMYSVLREETNKVQFLKDHNSGVLPRGALSNGVKGLDEALSTFERARKHDLIN
                      . .   .|.|....|||| |..|..|..||||||...|..||....|.|||||||.| .||.|.||.||.|.|.||||
......................skeesesekrkevirnkiraigklarvfsvlreesesvlllkglttgalprgalsegkegleeklssfeeakkldlin

EKLPP
|||||
eklpp
0045823 Metallo-dependent phosphatases 72-596 4e-145 476.9 In-house 5-472 (473) alignment 
Range on Protein: 72-596
Range on HMM: 5-472/473.0
MNKVPAITSHVPTDEELFQPNGIPRHEFLRDHFKREGKLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLG
.. |. ......| ..|| ..|.. ...|..|.|.||.|.. .. .... |.|...|||||. ....|.|.||||||..|||.|.|  | |  . ..|||
lklvlipvlrlltlpllfillglldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflG

DYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNR
|.||||..| |.| .|..||........|||||||...|. .. |..|.|.||. |.|| ..| ...|||||. .|..|.||||.||.|..|..|....|
DlvDrGpdslevlelllalkikypgnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireier

FREIPSHGLMCDLLWADPieeYDEVLDKdlteedivnsktmvphhgkmaPSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKN
..|||..||..||||.||    .. .|.                      .| .| .||.||..| |...|...||.. ||  |.|.|.... ||... .
pleipddgllldllwsdP...weddgdg.....................llrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfd

TKTLGFPSLLTLFSAPNYLDTYNNKAAILKYENNVMNIRQFNMTPHPYWLPDFMDVFTWSLPFVGEKVTEMLVAILNICTEDELENDTPVIeelvgtdkk
 |..|.....|.||||||.....|.||.|..........||...|||..|| |.|||..||||..||.||.|. .|||...|||..|....         
gkvigiDtgiTvfSApnYcgrggnlaAvlvidedlisfiqfdpsphplilplfldvfllslpfllekltellllllnivsddellededil.........

lpqagkseatpqpatsaspkhaSILDDEHRRKALRNKILAVAKVSRMYSVLREETNKVQFLKDHN-SGVLPRGALSNGVKGLdeaLSTFERARKHDLINE
                      ..|  |.....|||||||. |..|..||||||...|. ||... ||.||.|.|..| . |   |...|.|.|.|||||
......................glllleallellrnkilalgkllrvfsvlreesesvlllkgltpsgllplgllllgkell...lesleealkldline

KLPPSLDELKNENKKYYEKVWQKVHE
|||||| .|. |..|..|........
klppsllllsleeekslelinerles
0049330 Metallo-dependent phosphatases 85-421 3.5e-93 305.1 In-house 5-305 (309) alignment 
Range on Protein: 85-421
Range on HMM: 5-305/309.0
DEELFQPNGIPRHEFLRDHFKREGKLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECL
|. |...  ..  ..|.........||  .. .... |.|.. .||||......|.|.||||||..|||.|.|  | |  . ..||||.||||..| |.|
dpllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevl

IYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDL
 .|..||| ..|...|||||||. .|. .. |..|.|.||. ...|.... ...|||||. .|..||||||.||.|..|..|..|.|..||| .||.|||
llllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdl

LWADPIEEYDEvldkdlteedivnsktmvphhgkmapsrdmFVPNSvRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLF
||.||......                              |.||  ||... |.. | ..||.  ||  |||.|.|.. ||... . |      |.|.|
lwsdplpireg..............................fapnp.rglgvvfghtaverflkkngldliirghgavfgGyltffdgk......litvf

SAPNYLDTYNNKAAILKYENN-VMNIRQFNMTPHPYWL
|||||.....|..|.|..... |.....|...|....|
sapnycgrlgnlgavleidedlvisfllfepvplllll
0053225 Metallo-dependent phosphatases 97-414 5.8e-85 278.2 In-house 9-290 (293) alignment 
Range on Protein: 97-414
Range on HMM: 9-290/293.0
HEFLRDHFKREGKLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFND
...|......  .||. .. .....|.|...|||||......|.|.|||||...|||.|.|  | | .. ..||||.||||..| |.| .|..||| ..|
ldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypd

HFWLLRGNHECKHLTSYFTFKNEMLHKY-NLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEYDE
...|||||||...|. .. |..|.|.|| . .... ... ...|||||| .|..|.||||.||.|..|..|...||. .|| .||..|||| || . .. 
nvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdlwsgw

VLDKdlteedivnsktmvphhgkmapsrdmfvpnsvRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNtktlgfPSLLTLFSAPNYLDTYNN
. ..                                ||... | . | . ||.  ||  |||.|.... ||... .      ..|.|.|||||||....|
lpsy................................rglgvvfghtavlrflkkngldliirghqvvpdgylpwfd......gklvtvfsapnylgrlgn

KAAILKYENN-VMNIRQFNM
..|.|..... |... .|..
lgavlaldeglvwgfklfap
subfamily_PPP7C_pd Subfamily PPP7C 99-407 3.2e-41 134.3 In-house 22-326 (383) alignment 
Range on Protein: 99-407
Range on HMM: 22-326/383.0
FLRDHFKREGKLSAAQAARIVTLATELFSKEPNLISVP----APITVCGDIHGQYFDLLKLFEVGGDPAT-TSYLFLGDYVDRGSFSFECLIYLYSLKLN
 | ..||.. .| |   . |.  | . . . ||.  |       .|||||.||.  ||| ..   | |..  .|.| ||.||||. | | |. |..| | 
klieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllv

FNDHFWLLRGNHECKHLTSYFTFKNEMLHKY---NLDIYEKCCESFNNLPLAALMNGQYLCVHGGISpELNSLQDINNLNRFREIPSHGlmcdllwaDPI
.  ...| ||||| . |   . | .|. .||   . .| .   . |  ||||.|.. . | |||||| .  .|. .....| .               |.
ypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiersklvsvlr........ppl

EEYDeVLDKDLTEED----IVNSKTMVPHHGKMAPSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSA
.|     .|.  |.       . . ..        ...  .||..||    |    . ..||  .|  .||.|| .  || . ...|      .||.|||
kege.eaekekeessvkvdkeewrqvldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkk......vltifsa

PNYLDTYNNKAAILKYENNVM
 || ..  |. | .|  ....
snyyeeGsnrGayvklgkdlt
subfamily_PPP5C_pd Subfamily PPP5C 101-292 2.2e-57 187.5 In-house 25-222 (322) alignment 
Range on Protein: 101-292
Range on HMM: 25-222/322.0
RDHFKREGKLSAAQAARIVTLATELFSKEPNLISVPAP----ITVCGDIHGQYFDLLKLFEVGGDPAT-TSYLFLGDYVDRGSFSFECLIYLYSLKLNFN
 ..|| . ||    |..|.. |.||..|.| |. .  .    .|||||||||..||| .||. | |..  .||| ||.|||||||.|... |...|| . 
lelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyP

DHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGIS-PELNSLQDINNLNRFREIPSHGLMCDLLWADPIEE
.||.| ||||| ...   . |..|. .||.  ...   |.|| |||| ..| ..| ||||.   .  .|.|. ...|... |..||...|||.|| |.
nhfflsrGnhesdnmnklyGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqea
subfamily_PPP1C_pd Subfamily PPP1C 106-295 1.6e-69 227.2 In-house 6-195 (282) alignment 
Range on Protein: 106-295
Range on HMM: 6-195/282.0
REGKLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNH
.| ||. |.  .... | |.. ..| |. . ||....||||||| |||.||| .| |....|||||||||||..| | .. | ..|........||||||
kevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnh

ECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEYDE
|..... .. |..|. ..|. .....  . || ||||||.. . ||||||.||||.||..|....|  |.|..||.|||||.|| .|  .
esasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlg
subfamily_PPP2C_pd Subfamily PPP2C 106-290 5.1e-60 196.1 In-house 13-198 (290) alignment 
Range on Protein: 106-290
Range on HMM: 13-198/290.0
REGKLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNH
.  .|. .. ....  | |..||| |.  | .|.|||||.|||..|||.|| .||.   | ||||||||||| .| |.. .| .||. ...   .|||||
eckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnh

ECKHLTSYFTFKNEMLHKY-NLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPI
| . .|  . | .| | || | ....   . |. |||.||...| .|.|||.||....|..|..|.|..|.|  | .|||||.|| 
esrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 109-409 4.2e-55 180.0 In-house 5-294 (302) alignment 
Range on Protein: 109-409
Range on HMM: 5-294/302.0
KLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGG--DP---------ATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDH
..|  .   ..   .||..|| .|. . .|.|. ||||||. ||....      .          ..  ..|||||||||| | ||.  ...||. .. .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FWLLRGNHECKHLTSYFTFKNEMLH----KYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNR-FREIPSHGLMCDLLWADPIee
. |||||||.| .   ..|..|.      |   .|.||  | |  .|||||.  . ||||||||| |.||.||....| . |.    |  |||.|||.  
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpl..

ydevlDKdlteeDIVNSKTMVPHhgkmapsrdmFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDT
     |      . . . .  |.          .. | ||| |. |   |  .. .  .|  |.|||    .|.... . |      |||.||||.|.. 
.....dv.....qllaavsekPk..........yaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymne

YNNKAAILKYENNV-MNI
 .|| |.|| . |  ..|
sdnkGavlkvdtngklsi
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 109-291 1.9e-45 148.3 In-house 6-204 (302) alignment 
Range on Protein: 109-291
Range on HMM: 6-204/302.0
KLSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGG--DP---------ATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDH
..|  .   ..   .||..|| .|. . .|.|. ||||||. ||....      .          ..  ..|||||||||| | ||.  ...||. .. .
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FWLLRGNHECKHLTSYFTFKNEMLH----KYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNR-FREIPSHGLMCDLLWADPIE
. |||||||.| .   ..|..|.      |   .|.||  | |  .|||||.  . ||||||||| |.||.||....| . |. .  |  |||.|||..
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpld
PPP_3 110-407 4.7e-93 304.1 In-house 2-263 (271) alignment 
Range on Protein: 110-407
Range on HMM: 2-263/271.0
LSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKH
||. .....|. ..|...||.||... ||.|||||||||. |||.||..||....|.|||||||||||..|.|.|..|..||........|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

LTSYFTFKNEML-HKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLwadpieeydevldkdlteedivn
......||.|.| .|.. ..|.|..| |. ||||||.....|.||||.||...||..|..|.|..|.|..|...|||                       
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll.......................

sktmvphhGKMAPSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNtktlgfPSLLTLFSAPNYLDTYNNKAAILKYENNVM
         .  |... .. ||.||....|. .....||... |  ||||||....||.....       ...|.||||||.....|..|||| |.. .
........lssdpekeeglenskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhd......gkvvtvfSapnycerasnagailkleealt
subfamily_PPP6C_pd Subfamily PPP6C 110-292 4.2e-57 186.5 In-house 15-197 (290) alignment 
Range on Protein: 110-292
Range on HMM: 15-197/290.0
LSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKH
|. ... ... | ..|...| |. .| .|.|||||||||..||..||  ||.   |||.||||.|||| .|.| . .| .||... |.  |||||||...
lpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrq

LTSYFTFKNEMLHKY-NLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPiEE
.|  . | .| |.|| | . .  |.. |. |..||....| ||||||.||... |..|. ..| .||| .| .|||.|.|| |.
itqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.ed
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 110-163 1.6e-08 27.0 In-house 11-64 (339) alignment 
Range on Protein: 110-163
Range on HMM: 11-64/339.0
LSAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPA
. ||. | ..  | ||   || .. . ||| | ||||||. ||| .... | | 
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpl
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 111-293 1.3e-60 197.9 In-house 25-208 (298) alignment 
Range on Protein: 111-293
Range on HMM: 25-208/298.0
SAAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHL
. ..  ....||...|.| . |. | |||.||||||||| |||.||. .| | .. |||||||||||....| .. | . |... ..|.||||||||...
keedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnheceai

TSYFTFKNEMLHKY-NLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEY
   . |..|. ..| .| .|..  . || |||.||. |. ||.|||.|..|.||.....|.|  . ... |  ||||||| .  
nrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenav
PPP_1 112-399 3.1e-102 334.4 In-house 3-261 (264) alignment 
Range on Protein: 112-399
Range on HMM: 3-261/264.0
AAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLT
....|.... ..||..||.||..| ..||||||||||..||||||.|||....|.|||||||||||..|.|.|..|..|||.......|||||||....|
eeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvt

SYFTFKNEML-HKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADpieeydevldkdlteedivnsk
....||.|.| .||. .||. ....|. ||||||.....|.||||.||||..|..|....|..|.|..| .||||..|                      
kvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekd......................

tmVPHHGKMAPSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKTLgfpsllTLFSAPNYLDTYNNKAAI
  | .. .. ......|.||.||..|.|.......|||...| .||||||....||...|..|..      |.|||.|| .. .|..|.
..vdillsddkeqeeavansiRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvv......tifsasnyyeegsnrgay
PP2Ac_SM00156 112-408 9.8e-93 303.1 In-house 3-262 (271) alignment 
Range on Protein: 112-408
Range on HMM: 3-262/271.0
AAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLT
. ......  . |....|.||. | ||.||.||||||. |||.|.| .| |... |.|||||||||..| |....|..||. . ... |||||||.....
keevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvn

SYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPieeydevldkdlteedivnskt
 ...|..|. .||. .||||. | |. ||||||.. ..||.|||.||||.||.||..|.|..|.| .||..||||.||                      
kiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp......................

mvphhgkmAPSRDMFVPNSvRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTktlgfpSLLTLFSAPNYLDTYNNKAAILKYENNVMN
          . . | |.. ||.|. |. .|...||..  |  ||||||..| ||.....       .|.|.||||||.| ..||||.||.|.|.. 
........eqkekgfqpsk.rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadk......klvtifsapnycdefsnkaavlkveknlkl
subfamily_PPP4C_pd Subfamily PPP4C 112-291 5.6e-63 205.8 In-house 18-198 (288) alignment 
Range on Protein: 112-291
Range on HMM: 18-198/288.0
AAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLT
  .  .. . | |.. .| |. .| .|.|||||||||..|||.||.||||   |.||||||.|||| .| |... | .||. . |.  |.|||||....|
eeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqit

SYFTFKNEMLHKY-NLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIE
  . | .|.|.|| . .... |.| |. |.|||...|. .|||||.||....|..|  ..| .|.| .| .|||||.|| .
qvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdped
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 112-294 2.8e-56 183.6 In-house 12-196 (287) alignment 
Range on Protein: 112-294
Range on HMM: 12-196/287.0
AAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLT
  .   ..  . |..   | |. | ||||..||||||. |||..|.  | .. . |||||||||||. |.|  ..|.|||. .. .  |||||||.|.. 
dkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkin

SYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREI--PSHGLMCDLLWADPIEEYD
  . ||.|. .|..  .|..  . |..||| | .. . ||.||||||.|.||.... |.. .      .||. ||||||| .. .
klyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdak
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 112-297 3.7e-49 160.3 In-house 18-205 (290) alignment 
Range on Protein: 112-297
Range on HMM: 18-205/290.0
AAQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLT
  .   |.  . |..   | |. | |||.. ||||||  .||. |.  | |    .||||||||||. |.|  ..|. .|. .. .  |||||||.... 
dkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvn

SYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFR--EIPSHGLMCDLLWADPIEEYDEVL
  . ||.|.  | .  .. .  . |..|.| | .. . ||.|||||....| . .. |.. |      .||. ||||||| .. |. .
rlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddti
subfamily_PPZ_pd Subfamily PPZ 113-299 6.2e-54 176.5 In-house 28-214 (300) alignment 
Range on Protein: 113-299
Range on HMM: 28-214/300.0
AQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTS
..  .|.  | |||  .|.|. .  .. . ||.|||| |||.||   | | .. |||||||||||  |.| .. |.  |... . |.||||||||  .| 
seilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtr

YFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEYDEVLDK
 . | .|  .. |. |..   ..|| |||||.. |. .|||||.|| |||...|  . |  ..|  ||. ||||.|| .  .|  |.
vygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewedn
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 113-164 1.6e-10 33.6 In-house 12-63 (317) alignment 
Range on Protein: 113-164
Range on HMM: 12-63/317.0
AQAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPAT
.. . .   | ||| |||  ... ||.|..||||||. ||| |... | | .
kelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpls
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 114-292 5.8e-54 176.1 In-house 10-188 (280) alignment 
Range on Protein: 114-292
Range on HMM: 10-188/280.0
QAARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSY
.  |..   ..... .  .. | ||..||||.|||| |||.||.  . |  . |||||||||||.. .| .. | . |. . ..| .||||||. ..   
didrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinrk

FTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEE
. ||.|. ..|.|..|..  | ...|||.||..|. ||.|||.|..| ||.|...| |  . . . |  ||||||| ..
ygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenk
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 115-297 1.9e-48 158.3 In-house 28-213 (297) alignment 
Range on Protein: 115-297
Range on HMM: 28-213/297.0
AARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYF
  ... || ..| .. ... | ||| ||||||||. |||.||  || | |. ||||||||||| || | .. | . |..|   ..||||||||. .   .
vlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvy

TFKNEMLHKYN-LDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELN---SLQDINNLNRFREiPSHGLMCDLLWADPIEEYDEVL
 | .|  ..|. . .|    . || |||. |.  . ||.|||.|| |    .|. .....| .|    .|..||||||||     ..
gfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisglsgfm
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 116-293 5e-50 163.3 In-house 14-191 (281) alignment 
Range on Protein: 116-293
Range on HMM: 14-191/281.0
ARIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFT
  ..  .  .||.| .|. . .||.| ||.|.|. || .|||. | .. . ..|||||||||  |.|.|| |..||. ..|. .|||||||  ..   . 
envireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiyg

FKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEY
| .|   ||  ... .  . ||.||..||.. . ||.|||.|||| .|... |  .  . .  ||. ||||||| .. 
fyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkv
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 117-295 1.1e-49 162.4 In-house 15-199 (284) alignment 
Range on Protein: 117-295
Range on HMM: 15-199/284.0
RIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDP------ATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHL
..   | ||| ||.  . . ||....||||||. ||| |... | |        . ||||||||||| || | .  |...|| . |.  ||||||| . .
elcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhesrpv

TSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEYDE
   . | .|  ..|   .||    .|| .||.|... . .|.||||| .| .|.....|.|  .||  |...|| |||| .| . 
nmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaeveg
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 117-291 1.9e-49 161.5 In-house 31-206 (299) alignment 
Range on Protein: 117-291
Range on HMM: 31-206/299.0
RIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTF
.....| . | ... |. | ||| ||||||||| |||..|.. | |  . .||||||||||   .| .. |.  |... ..|..|||||||  .   . |
tlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpainrvygf

KNEMLHKYNL-DIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIE
 .|  ..|.   ..    ..|. .||. |.... ||.|||.||.|..|. . .|.| .. |.  |  ||||||| .
yeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdq
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 117-292 4.5e-43 140.7 In-house 13-188 (280) alignment 
Range on Protein: 117-292
Range on HMM: 13-188/280.0
RIVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTF
 |. .   .| .| ||.   ||| | |||| || |. .||.. |       .|||||||||    | || |. ||. . |. .|||||||   .   . |
aiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygf

KNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEE
  |  .|| . ..      || .|...|.. . ||.|||.||||  |. | |. |  |   .||. ||||.|| ..
yvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnk
subfamily_PPG1_pd Subfamily PPG1 118-405 1.9e-62 204.2 In-house 22-285 (300) alignment 
Range on Protein: 118-405
Range on HMM: 22-285/300.0
IVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFK
..    ||. || |.| . .|.|| ||.|||..|.|..|..||.   | ||||||||||| .| | .. |  ||| .     ||||||| . .|  . | 
ltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqitqvygfy

NEMLHKY--NLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADPIEEYDEVLDKdlteedivnsktmvP-
.| |.||  |  ...   | |. | |||... .  |||||.||.  |...|. |.||||.| .| ..||||.|| |. . .||.              | 
teclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldh..............pd

HHGKMapsrdmFVpNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENN
..|.       || .| ||. |..    . .||.   .  |||||.    ||... ..|      | |..|||||     |||.||. ...
regqh......fv.vsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnk......lstvwsapnycyrcgnkasilelyek
subfamily_PPPLV_pd Subfamily PPPLV 118-407 1e-48 159.1 In-house 5-281 (290) alignment 
Range on Protein: 118-407
Range on HMM: 5-281/290.0
IVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLL----KLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSY
.   | . . .| .|. . .|. | ||.||.| ||     .|. .| | . .|.|||||||||| ||.| . ||..||. .  ...||||||| . ..  
lcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqes

FTFKNEMLHKYNL---DIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDI---NN-LNRFR-EIPSHGLMCDLLWADPieeydevldkdlteed
...| |  .|.     ...|   . |. ||||| .. . .|||.||     .   |   .. |.|.. .|    |  |.||.||                
ieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdp................

ivNSKTMVPHHGKMApSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENN
  ...   .  |...   . ||.|. || .. |.  |   ||....|  ..||||....|.|. ....      |||.||. .|  . |. | ||  ...
..aedrdlslrgelv.lneGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgr......lltvfsssrycGssneaalilvdkkk

VM
. 
lr
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 118-290 6.5e-45 146.7 In-house 11-185 (284) alignment 
Range on Protein: 118-290
Range on HMM: 11-185/284.0
IVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFK
..  | ..| |.| || | .|| .|||||||. |||.||.  | |  . |||||||||||   .| .. |.. |. | .||..|||||||  .   . | 
llfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiygfy

NEMLHKYNL-DIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIP-SHGLMCDLLWADPI
.|  ..||   .|      | ..||.||.  . ||.|||.|  |. . ..  ..|  . |    |  |.||.|| 
eecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdpt
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 118-289 1.2e-38 126.0 In-house 28-202 (307) alignment 
Range on Protein: 118-289
Range on HMM: 28-202/307.0
IVTLATELFSKEPNLISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFK
..  |  .|| |  |. .  |  | ||.|||. ||...| . | |  | |.| ||||||| .|.||.. |.. |. . ..  |||||||  ..   ..| 
viyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfy

NEML---HKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLWADP
.| .    |   .|.      |||||..||.  . ||.|||.|| |  |... |  .    |  |.. |.|||||
eecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 132-292 1.6e-44 145.6 In-house 2-168 (263) alignment 
Range on Protein: 132-292
Range on HMM: 2-168/263.0
LISVPAPITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNL-DIYE
|. . ||| .||| |||| |||..|.  |  . | ||||||||||| .|.| .. |.|||| .  .. ||||||| | .   . |. |. ....  ..||
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KCCESFN----NLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFRE-IPSHGLMCDLLWADPIEE
   . ||     .||.|... . ||.|||||| |.||.||  .    |   .| | |||||||| ..
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekd
Metallophos Calcineurin-like phosphoesterase 138-362 7.5e-44 143.4 Pfam-A 2-199 (200) alignment 
Range on Protein: 138-362
Range on HMM: 2-199/200.0
PITVCGDIHGQYFDL----LKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYL--YSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEML----------
.|.|.||.||.. ||    |.|.......  . .|||||.||||  | |.| .|  ..|||.......|||||||.....|.. |..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

------------------------HKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQDInnlnrfreipshglmcdllwadpieeydevl
                        .... ...|...| |..|||.|| .|..|..||..|....|  ||                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

dkdlteedivnsktmvphhgkmapsrdmfvpnsvrgCSYAFTYRAACHFLQETGLLSIIRAHEAQ
                                    .|. | ..| . .|.. |.  ..|.|. .
....................................gselfgpdalekllekygvdlvlrGHtHk
PPP_4 139-362 5.8e-74 241.4 In-house 1-197 (197) alignment 
Range on Protein: 139-362
Range on HMM: 1-197/197.0
ITVCGDIHGQYFDL-LKLFEVGGDPA-TTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESF
.||.||||||..|| |||...||.|. ..||.|||||||||..|.|.|..|..|||.......|||||||.|.|.....||.|.|.|.. .|..|....|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvf

NNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIP-SHGLMCDL-LWADPIeeydevldkdlteedivnsktmvphhgkmaPSRDMfVPNSVRGC
. ||||||.....|.||||.|.||.||..|....|..|.| ......|| ||.||                               .. .. . |||||.
dllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr..............................eaqeg.lansvrGa

SYAFTYRAACHFLQETGLLSIIRAHEAQ
...|.......||....| .|||.||..
gllFgpdvtekfleknnlkliirshelk
PPP_5_Dcr2 139-361 4.3e-71 232.0 In-house 1-198 (199) alignment 
Range on Protein: 139-361
Range on HMM: 1-198/199.0
ITVCGDIHGQYFDL-LKLFEVGGDPA-TTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHK-YNLDIYEKCCES
.|||||.|||..|| |.||. ||||. ...|.|||||||||..|.|.|..|..|||.......|||||||...|.....|..|.|.| .. .||......
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FNNLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIP-SHGLMCDL-LWADPIeeydevldkdlteE----DivnsktmvphhgkmapsrdmfVPN
|. ||||||.....|.||||.|||..|........|..||| ..| ..|| ||.||              .    .                       |
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr.............daqegc.....................kln

SVRGCSYAFTYRAACHFLQETGLLSIIRAHEA
|.||....|.......||....|  |||.||.
seRGagllfgpdvtekfleknnlkliirshel
PPP_2 139-361 1.2e-69 227.0 In-house 1-197 (198) alignment 
Range on Protein: 139-361
Range on HMM: 1-197/198.0
ITVCGDIHGQYFDLLKLFEVGGDPATTSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEML-HKYNLDIYEKCCESFN
.|||||.|||. |||.||..|.......|||||||||||..|.|.|..|..|||.......|||||||.|.......||.|.| .|.. ..|.|..| |.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

NLPLAALMNGQYLCVHGGISPELNSLQDINNLNRFREIPSHGLMCDLLwaD--PieeydevldkdlteedivnsktmvphhGKMAPSRDMFVPNSVRGCS
 ||||||.....|.||||.|.|...|..|.. .|..|.|..|...|||                                  .  .... .. ||.||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll..eeek...........................lsdpkekeellansarGag

YAFTYRAACHFLQETGLLSIIRAHEA
..|. ......|... |  ||||||.
llfgpdvteelleknklkliiRaHev
subfamily_YNL217W_pd Subfamily YNL217W 139-222 5.3e-07 22.4 In-house 12-86 (235) alignment 
Range on Protein: 139-222
Range on HMM: 12-86/235.0
ITVCGDIHGQYFDLLKLFE--VGGDPATTSYLFLGDYVDRGSFSFECLIYLyslklnFNDHFWLLRGNHECKHLTSYftfknEMLH
. | ||.|| | .|..|..  .||       ...|| ...|  | | . |.       .|.   ..||||   | .|     ....
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllay.....kwvk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 165-294 3e-40 131.3 In-house 101-230 (317) alignment 
Range on Protein: 165-294
Range on HMM: 101-230/317.0
TSYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQ
  ||||||||||| ||.| .| |..||| . |. .||||||| . .   . | .|. ..|.  .||     || |||.|..| . ||.||||| || .|.
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

DINNLNRFREIPSHGLMCDLLWADPIEEYD
 ...|.|  .||  |...|| |||| .| .
qldklkrpldipdvGvladltwadpdaevk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 166-289 2.6e-34 111.8 In-house 121-244 (339) alignment 
Range on Protein: 166-289
Range on HMM: 121-244/339.0
SYLFLGDYVDRGSFSFECLIYLYSLKLNFNDHFWLLRGNHECKHLTSYFTFKNEMLHKYNLDIYEKCCESFNNLPLAALMNGQYLCVHGGISPELNSLQD
 ||||||||||| ||.| .| | .||| . |. .||||||| . . . . |  |. ..|. ..||   . || .|..|..|   .|.|||||  | |...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

INNLNRFREIPSHGLMCDLLWADP
.  ..|  |||  |.. || ||||
fsvfkrpleipdvgvltdltwadp
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 297-407 8.7e-12 37.8 In-house 189-293 (302) alignment 
Range on Protein: 297-407
Range on HMM: 189-293/302.0
LDKDLTeEDIVNSKTMVPHHGKMAPSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNK
 .  |. .|.. . ..  .  ......  .. | ||| |. |   |  .. .  .|  |.|||    .|.... . |      |||.||||.|..  .||
tedsla.qdllfadpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkk......lltifsaprymnesdnk

AAILKYENNV-M
 |.|| . |  .
Gavlkvdtngkl
subfamily_PPP4C_pd Subfamily PPP4C 307-407 2e-10 33.3 In-house 176-276 (288) alignment 
Range on Protein: 307-407
Range on HMM: 176-276/288.0
VNSKTMVPHHGKMA------PSRDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAIL
.. |. |||.| ..      |        | ||  | |  ... .| .. ..  |.|||.    ||... | |      .||..|||||     |.||||
idrkqevphegplcdllwsdpedaegwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnek......vltvwsapnycyrcgnvaail

KYENNVM
...... 
eldeeld
subfamily_PPP5C_pd Subfamily PPP5C 323-419 2.9e-15 49.1 In-house 221-313 (322) alignment 
Range on Protein: 323-419
Range on HMM: 221-313/322.0
RDMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKY--ENNVMNIRQFNMTPHPY
. . . .| || . .|    . .||.| .|  |||.|| .. ||.. .. |      |.|.|||||| |. .||.|...   ... .....|.  .|| 
eanGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGk......litvfsapnycdqmgnkgafitlrgddlklkfktfeavehpd
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 324-416 4.5e-09 28.6 In-house 196-281 (287) alignment 
Range on Protein: 324-416
Range on HMM: 196-281/287.0
DMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYeNNVMNIRQFNMTP
. | .| .|. |  |  .   ..|.. ..  |.|||| .. || .. . .      |.|.|||| |     | .|...  .......  .. |
ktfelnkiraisvvfGkkevddllkkldidlivrahevseeGyaflfdkr......lvtvfsapyysgedtnlgavvvv.skslelsfvvlkp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 324-403 1.7e-07 23.5 In-house 203-276 (290) alignment 
Range on Protein: 324-403
Range on HMM: 203-276/290.0
DMFVPNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYE
| .  |  |. |  |  ..  ..|.. .|  |.|||| .. |. .  . |      |.|.|||| |     |  ||..  
dtialnkqraisvvfgkkglddllkklalslivrahevkeegfnflfdkk......lvtvfsapyysgndtnlgaiatvs
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 327-406 4.3e-08 25.9 In-house 192-264 (284) alignment 
Range on Protein: 327-406
Range on HMM: 192-264/284.0
VPNSvRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNV
 ||| || || |   |  ..|.   .  ..|||.  . || .. | .      |.|.|||| |   ..| ||..  ..|.
npns.rgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrr......lvtifsapfycgqfdnaaavmyvnknl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 328-407 1.1e-10 34.2 In-house 233-306 (317) alignment 
Range on Protein: 328-407
Range on HMM: 233-306/317.0
PNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNVM
 .| || .  |  .|  .||..  |  ..|||.    || .... |      |.|.||||.|    .| ||.|. .....
kesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrk......lvtifsapsycGqldniaavlsvdkklk
subfamily_PPP2C_pd Subfamily PPP2C 328-416 1.8e-09 30.2 In-house 204-287 (290) alignment 
Range on Protein: 328-416
Range on HMM: 204-287/290.0
PNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNVM-NIRQFNMTP
  | ||. |.|    . .| .. ||  |.|||.    ||..  . .      . |.||||||     |.||||. ....  .. ||. .|
gisprgagytfgkdisekfnktngltliarahqlvmegynwshdrn......vvtifsapnycyrcgnqaailelddklkysflqfdpap
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 328-407 1.6e-08 27.3 In-house 201-274 (284) alignment 
Range on Protein: 328-407
Range on HMM: 201-274/284.0
PNSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNVM
 .| ||.   |  .|  .||..  |  ..|||.    || .. . |      |.|.|||| |   ..| ||.|. .....
kesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrk......lvtifsapsycgqldniaavlnvdeelv
subfamily_PPP1C_pd Subfamily PPP1C 329-407 1.6e-13 43.5 In-house 198-270 (282) alignment 
Range on Protein: 329-407
Range on HMM: 198-270/282.0
NSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNVM
.. || |..|  ..  .|||.. |  |.|||.  ..||..... .      |.|.||||||.....|..|.|. .....
endrGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrq......lvtvfsapnycgefdnagavlsvdeell
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 329-407 3.9e-10 32.2 In-house 213-285 (298) alignment 
Range on Protein: 329-407
Range on HMM: 213-285/298.0
NSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNVM
.. || |. |   .  ..|..  .  ..|||     || .. . |      |.|.||||.|.. ..| ||..| .....
ensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekk......lvtifsaphycgqfdnsaavmkvdeklv
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 329-418 7.5e-10 31.5 In-house 196-278 (281) alignment 
Range on Protein: 329-418
Range on HMM: 196-278/281.0
NSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNvMNIRQFNMTPHP
.|.|| |. |      .  .. ..  |||||    .||.. .  |      |.|.||.||| . |.| ||.|| ... ..|.  .. |..
assrGssftfGknvvddvckrleveliirahqvvqdGyevlsgrk......litvfsvpnycafyknaaavlkvdet.lgislvalvpas
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 329-404 1.8e-08 26.9 In-house 253-322 (339) alignment 
Range on Protein: 329-404
Range on HMM: 253-322/339.0
NSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYEN
 | ||.|. |   |   ||..  |  .|| |.  . || ..   .      |.|.||||||    .| ||..  ..
psargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrr......lvtifsapnycgqndntaavfsidk
subfamily_PPP6C_pd Subfamily PPP6C 329-412 9.2e-08 24.5 In-house 203-281 (290) alignment 
Range on Protein: 329-412
Range on HMM: 203-281/290.0
NSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNV-MNIRQF
 | ||  | |  . . .|..   |  |.|||.  . |.. . . |      | |..|||||     | |.||. |..   . . |
vsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdek......lvtvwsapnycyrcgnvasilaledaeereaklf
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 329-406 1.1e-07 24.3 In-house 194-265 (280) alignment 
Range on Protein: 329-406
Range on HMM: 194-265/280.0
NSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNV
.. ||.|. |      .. .   .  |.| |.  . || .. . |      |.|.||||.||. ..|.||.|. ....
ensrgvsvifganvvkdltekldidliarghqvvqdgyeffadkk......lvtvfsapkylgefdnsaavlivderl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 329-418 2.4e-07 23.5 In-house 194-276 (280) alignment 
Range on Protein: 329-418
Range on HMM: 194-276/280.0
NSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNVmNIRQFNMTPHP
 |.|| || |      .  .   .  |||||.  . || |    .      |.|.|| |||   . | ||..  . |. ..   .. | |
hsirgisymfgkgvveqacksleidliirahqvvqdgyemmagrr......litvfsvpnycaqftnaaavvclnanl.qvsfqqlippp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 329-412 5e-06 18.9 In-house 211-287 (307) alignment 
Range on Protein: 329-412
Range on HMM: 211-287/307.0
NSVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNvMNIRQF
 | ||  ..|         .  |.  |||||.    || .    |      |.|.|||| | . |.|  ..|| ..  . |.  
assrgsgftfgtnviddvckrlgveliirahqmcfdgywvlsgrk......litifsapmycnfyknagcvlkvdet.lgiqlv
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 330-408 6.5e-09 28.5 In-house 214-286 (299) alignment 
Range on Protein: 330-408
Range on HMM: 214-286/299.0
SVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTKtlgfpsLLTLFSAPNYLDTYNNKAAILKYENNVMN
 ||| || |      . ..  ..  . |||.  . || .. . |      |.|.|||| |   ..| |||.| ..|.. 
nvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskk......lvtifsaphycgqfdnsaaimkvdenlvc
subfamily_PPZ_pd Subfamily PPZ 330-404 8.8e-08 25.0 In-house 214-282 (300) alignment 
Range on Protein: 330-404
Range on HMM: 214-282/300.0
SVRGCSYAFTYRAACHFLQETGLLSIIRAHEAQDAGYRMYKNTktlgfpSLLTLFSAPNYLDTYNNKAAILKYEN
  || ||..   |  .||.. |.  . |||   . || ....       ||.|.||||||   ..|  |..   .
nergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndr......slvtvfsapnycgefdnwgavmsvse