Gene PPG1 in Saccharomyces cerevisiae

Synonym: YML016C, PPZ1

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPG1
Protein sequence
ID Type Fasta BLAST phosphatome Note
ScerP065_AA protein Get Run
ScerP065_AA_2-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPP2C_pd Subfamily PPP2C 2-300 2.5e-132 433.5 In-house 3-288 (290) alignment 
Range on Protein: 2-300
Range on HMM: 3-288/290.0
ELDECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYP
.||...|.| ... | | .|..|| | ||.| ||||| ....||||.||.||||||.||.|.||| .||||||||||||||| |||||. ||..||.||.
dldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvryk

SRIHLLRGNHESRQITQSYGFYTECLNKYGgNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENn
.|| .|||||||||||| |||| ||| ||| |. ||.|.||.|||| |....|..|||.||||||...|.|.|. .||..|.||.|...||.||||..  
eritilrgnhesrqitqvygfydeclrkyg.nanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr.

nptldhpdnSGqhFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFEEAPE
         .|  ...||||||||||. . ||| . |... | |||||. |||.  .|  |.|..|||||||||||.|.||||  | ...|. |. ||.
.........gg..wgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
subfamily_PPP4C_pd Subfamily PPP4C 2-300 3e-132 433.2 In-house 2-287 (288) alignment 
Range on Protein: 2-300
Range on HMM: 2-287/288.0
ELDECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYP
.||. .|.| ...|. | .|.||| | .|.||.|||| ....|||| ||.||||.|.||.|..|| ||.||||||||.|||| |||||..||..||.|||
dldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvryp

SRIHLLRGNHESRQITQSYGFYTECLNKYGgNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENN
 ||.|.|||||||||||.|||| |||.||| ...||.| |..|||| |..|||..||||||||||...|.|.|..||| .|.||.|...||.|||||. .
dritlirgnhesrqitqvygfydeclrkyg.sanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

NptldhpdnsgqhFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFEEAPE
             . |||||||| || .|||.| . ||.. | |||||  |||. .|.  | ||||||||||||||.|.|||| .. .  |..||.|..
g............wavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaaa
subfamily_PPP6C_pd Subfamily PPP6C 2-302 9.8e-122 398.6 In-house 1-288 (290) alignment 
Range on Protein: 2-302
Range on HMM: 1-288/290.0
ELDECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYP
|||. .|   |.. |||  ...|| .....|..||||  ...||||.||.||||.|..|.|. || ||||.|.||||.|||| ||.||. .|..||..||
eldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakyp

SRIHLLRGNHESRQITQSYGFYTECLNKYGgNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENN
.|| ||||||||||||| |||| ||||||| |. .|.|.|..|| | .. |||....||||||||.|.|.|||..|.| .||||.||..||||||||. .
dritllrgnhesrqitqvygfydeclnkyg.nanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedve

nptldhpdnsgqHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFEEAPEN
            ...|||||||| ||..|...|...|... | ||||| .||.. .||  . |||||||||||||| ||||.|  ...  ...|.  |..
............twavsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfkavpde

K
.
e
subfamily_PPG1_pd Subfamily PPG1 3-302 2.6e-202 663.5 In-house 1-300 (300) alignment 
Range on Protein: 3-302
Range on HMM: 1-300/300.0
LDECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPS
||||||.|.||.|||||||..|..||||.||||||||.|..|||||||.||||.|.||||.|||.|||||||||||||||||||||||.|||||||||||
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RIHLLRGNHESRQITQSYGFYTECLNKYGGNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNN
||.|||||||||||||.||||||||.|||||||||.|||.|||||||..|||.||.||||||||.|..|||||..|||||.|..||.|||.|||||||||
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

PTLDHPDNSGQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFEEAPENK
|||||||..||||.||.|||||..|..|||||||.||||||.||||||||||||.||....||||||||||||||||||||||.||..||||.|||||.|
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeapesk
0045823 Metallo-dependent phosphatases 3-302 4.1e-106 348.4 In-house 30-328 (473) alignment 
Range on Protein: 3-302
Range on HMM: 30-328/473.0
LDECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPS
||...|.|.| .|||| ... |. . ||.| ||.|..... ...|.|| |||..|.|..... |  |.....||||.|||| .|.|.. ||. ||..||.
ldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypg

RIHLLRGNHESRQITQSYGFYTECLNKYGGNsrVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPeenNN
...|||||||.|.... |||. |.| ||| .  ..... . ...| |...|.. |..|||||||.....|||. |.|..|||.||.. ||.||||    .
nvfllrGNHElrllnglygfgdetlekyged..lyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP...we

PTLDHpDNSGQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGL------VTTVWSAPNYCYRCGNKASILELYSKDqFYFNVFE
. .|       .|. |||||||.||. .||.||. |....| |.|. . |||...|||       . ||.||||||.|.||.|..|.. ..  ..| .|.
ddgdg.llrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfd

EAPENK
 .|  .
psphpl
0049330 Metallo-dependent phosphatases 3-300 3.1e-100 328.2 In-house 17-301 (309) alignment 
Range on Protein: 3-300
Range on HMM: 17-301/309.0
LDECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPS
||...|.|.| .||.| ... |..| ||.| .|.|..... ...|.|| |||..|.|..... | .|.....||||.|||| .|.|.. ||. |||.||.
ldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypd

RIHLLRGNHESRQITQSYGFYTECLNKYGgnSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNN
...|||||||.|.... |||. |.| |||  ...|....| ...| |...|...|.||||||||.....|||. ..|..|||.|| ..||.|||| .  .
nvfllrGNHElrllnglygfgdetlrkyg..aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpire

PtldhpdnsgqhFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFEEAPE
            |. .|||.|..||  .||.||. |....|.|.|... .||...||| . ||.||||||.|.||....||. ..  ..| .|| .| 
g...........fapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpl
0053225 Metallo-dependent phosphatases 3-298 3.4e-93 305.2 In-house 9-291 (293) alignment 
Range on Protein: 3-298
Range on HMM: 9-291/293.0
LDECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPS
|| ..|.|.. .||.| ... |... ||.|.||.|..... ...|.|| ||...|.|..... | .|.....||||.|||| .|.|.. ||. |||.||.
ldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypd

RIHLLRGNHESRQITQSYGFYTECLNKYGgNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPeennn
...|||||||...... |||. |.| ||| ....|..|.| ...| |...|...|..|||||||.. ..|||. |.|. .||..|...||.||||     
nvvllrGNHElmllnglygfgdetlrkyg.aaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp.....

ptldhpdNSGQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFEEA
       .   ..  |.||.|..||  .|..||. |....| |.||.. .||...||| . ||.|||||..|.||....|.| ..  . | .|.  
.......dlwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPP7C_pd Subfamily PPP7C 4-180 5e-40 130.4 In-house 21-202 (383) alignment 
Range on Protein: 4-180
Range on HMM: 21-202/383.0
DECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTP----VTVVGDMHGQFHDMLEIFQ-IGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKL
.. .| . . .||    |  . .. |..|..  |. ...|     ||| ||.||.. |.| |.   | | .. .|.| ||.||||  ||| ...|..| |
eklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalll

RYPSRIHLLRGNHESRQITQSYGFYTECLNKY-GGNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSpNVQTIDQIKIIDRF
 ||  ..| |||||   .   |||  |  .||   .... . | |.| .| |...||..|. ||||.| .   .. .. |.| 
vypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGis.dktdlelldkiers
subfamily_PPP5C_pd Subfamily PPP5C 5-298 1.4e-76 250.5 In-house 23-309 (322) alignment 
Range on Protein: 5-298
Range on HMM: 23-309/322.0
ECLERLYKAQLLPEVTVRALCFKLKEMLVKESNVIHIQTP----VTVVGDMHGQFHDMLEIFQIGG-PVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLR
| ||.. | . |..  . ..  . ||.| |.. ...|...    .|| ||.||||.|.|.||.. | | ..  ||| ||.|||| .|||.|..|. .|| 
ellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkll

YPSRIHLLRGNHESRQITQSYGFYTECLNKYggNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLS-PNVQTIDQIKIIDRFREIPHDGAMADLVWSDPE
|| ...| |||||| .. . |||  |. .||  ...| . .|..|..| |. .|..... |||||   .  |.|... |||... |..|.. .|.||||.
yPnhfflsrGnhesdnmnklyGfegevkaky..tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq

ENNnptldhpdnsGqhFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSK-DQFYFNVFEE
|.|          |   . | || | .||  | .|||. |... | |.|.. .|||..  || . ||.|||||| . |||.....| .. ..  |. || 
ean..........G..rspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea

A
 
v
subfamily_PPP1C_pd Subfamily PPP1C 13-296 2e-92 302.4 In-house 7-277 (282) alignment 
Range on Protein: 13-296
Range on HMM: 7-277/282.0
AQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHE
.  | | ...||. | .|.|.... ..... ||..|||.|||..|.| .|...|  |..||||||||||||  |.|||.||...|..||....|||||||
evklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhe

SRQITQSYGFYTECLNKYGGNsrVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNnptldhpdnsg
| .|.. |||| || ..|. .  .|. .||.|..| |. ..|..|.||||||||... ..||. | |  |.|..| ..||.||||....           
sasinriyGfydeckrrysik..lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkev...........

QHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFE
. .. . ||  .|||..||||||. ||.. | ||||. ..||. . .  . ||.|||||| . .|....|.. ..    |... 
lgwsendrGvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 13-296 4.8e-79 258.5 In-house 21-292 (298) alignment 
Range on Protein: 13-296
Range on HMM: 21-292/298.0
AQLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHE
.. . |  |  |. . |... | . .. ...|..| ||.|||. |.| .|. .|  ||.|||||||||||| ...|.|.||.. |..||... |||||||
tkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhe

SRQITQSYGFYTECLNKYGgNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNnptldhpdnsg
  .| . |||| || ..|  . |... . |.|. | |...| . |.|.|||||......||.. . |  . ...   .||.|.|||..            
ceainrvyGfyeeckrryk.slrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenav...........

QHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFE
. .. . ||....||. ||...|   |.. . ||||. ..||. . .  . |..|||.|| .  | |..... .| .  |.|. 
kgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlk
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 14-295 2.4e-74 243.4 In-house 6-280 (284) alignment 
Range on Protein: 14-295
Range on HMM: 6-280/284.0
QLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGG-P-----VPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLL
.|| |  .  ||.. .|.. ||.  ..|..||..|||.|||| |.| .... | |       ...||||||||||| .|.| |.||. .||..| .. ||
kllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfll

RGNHESRQITQSYGFYTECLNKYGgnSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNnptldh
||||||| . . ||||.|| ..|    .... .   |  . ||..... |.|.|||.| ..  ..|.. ..|  .||  | .|||.|.|||..       
rgnhesrpvnmqygfyleckkrys..ealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaev......

pdnsgQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVF
     .... |||||| .|| . |..||.. ... . ||||.  .||... |  . |..||| || .  | |..|.. ..    |.|.
.....egykesprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 14-66 2e-11 36.6 In-house 7-59 (317) alignment 
Range on Protein: 14-66
Range on HMM: 7-59/317.0
QLLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGG
.|. |  .  ||.. .|.. ||   .....|||.|||.||||.|.| .... |
dlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 15-285 8.8e-57 185.7 In-house 2-261 (284) alignment 
Range on Protein: 15-285
Range on HMM: 2-261/284.0
LLPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESR
|.|   | .| |.  ... |.  .| ...|. ..||.|||| |.| .|.  |    .|||||||||||| . .|||.||.  |. .| .. .||||||  
lippedvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecs

QITQSYGFYTECLNKYGGNSrVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMA-DLVWSDPEennnptldhpdNSGQ
 | . |||| ||  .|   | |.. .  .|  . | ... . |.|.|||.|  .| . |.. | |  . |   ..| |..||||            |  .
linkiygfyeecqrrynkps.vyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdpt...........nfqk

HFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELY
 ..   ||  | ||   . |.|   ... . ||||. ..||... .  . |..||| || .  | |... . 
gwnpnsrgvsyvfgsdalrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvn
PPP_3 16-296 2.4e-108 354.2 In-house 2-270 (271) alignment 
Range on Protein: 16-296
Range on HMM: 2-270/271.0
LPEVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQ
|.| ... |. ||||.| ||||...|..||||.||.|||..|.||.|..|||.|.|.||||||||||| .|.|...||..||..||...|||||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQSYGFYTECLNKYGgNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVwsdpeennnptLDHPDNSGQHF
|.. |||..|.|.|.| ...|...|...|..| |. .||.....|||||||.....|||| ..|..|.|..|.. ||            | ..... . .
inkvYgFkkevlkkkg.gkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldll...........lssdpekeegl

QVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFE
. |.||||..|| .|.|.||. |... | |||.|..|||.|..|| |.||.||||||.|..|...||.| ....  |...|
enskrGagllFgpdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_PPP3C_pd Subfamily PPP3C 18-297 1.1e-86 284.4 In-house 43-321 (452) alignment 
Range on Protein: 18-297
Range on HMM: 43-321/452.0
EVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQIT
| ..  .  .  ..| ||........|.||.||.||||.|.|..|..||   .|.||||||||||| .|.|... |  ||. |||...|||||||.| .|
eeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlt

QSYGFYTECLNKYggNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNNPTLdhpdNSGQHFQV
. . | .||  ||  . .|.. ... || | |  ..... .||||||||.....|.|| .|||.|.|. |.. ||.|||| |. . .     .. .. . 
eyftfkeeckiky..seevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeek....teekfvpn

SPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFD------GLVTTVWSAPNYCYRCGNKASILElYSKDQFYFNVFEE
|.||  | .. . | .||. ||.  | |||.  ..||. | .       ...|..|||||.    |||..|. | ....    |. 
svrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlk.yennvmnirqfns
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 18-295 1.4e-69 227.6 In-house 26-291 (299) alignment 
Range on Protein: 18-295
Range on HMM: 26-291/299.0
EVTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQIT
|  .. ||   |....... .. ...|. |.||.|||. |.| ||.. |  ||.|.||||||||||   .|.|.||.. |..|| |...||||||   | 
eqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecpain

QSYGFYTECLNKYGgNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPeennnptldhpDNSGQHFQV
. |||| || ..|   .|.|  . | |... |. .|   |.|.||||||..||.||.. . | .. |      ||.|.||           |.| . .. 
rvygfyeecnkryk.strlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadp...........dqsvkdwla

SPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVF
  ||  | ||. ||.. .   |.. . ||||. ..||... .  . |..||| || .  | |.|...  .    | |.
nvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvl
PPP_1 19-283 1.1e-109 358.8 In-house 4-263 (264) alignment 
Range on Protein: 19-283
Range on HMM: 4-263/264.0
VTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQ
 ....|. ||||.|.||.|........||.||.||||.|.|..|..|||.|.||||||||||||| .|||...||..|||.||....||||||||||.|.
eelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqvtk

SYGFYTECLnKYGGNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDpeenNNPTLDHPDNSGQHFQVS
 |||..|.| |. ........|||.||.| |...||..|..|||||||.....|||....|..|.|..|.. ||...|    .. .|...... .... |
vygFkkEvl.kkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekd....vdillsddkeqeeavans

PRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILE
.|||||.||..|.||||. |... |.|||....|||...... |.|..||.||.....|......
iRGagylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 19-296 9.7e-69 224.6 In-house 9-273 (280) alignment 
Range on Protein: 19-296
Range on HMM: 9-273/280.0
VTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQ
. . ..  | |..|. .. .. ...||.|.||.|||. |.| .|.  .  ||.|||||||||||| . .| |.||.  |.||| .. .||||||  .| .
adidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinr

SYGFYTECLNKYggNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNnptldhpdnSGqhFQVS
 |||. |. ..|  .  ... . ...| | |....   |.|.|||||......|... . |  . ...    ||.|.|||..          .|  .  .
kygfkdevkrry..slalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkv.........tg..waen

PRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFE
.||. . ||  || .. .. |.. | | ||. ..||... |  . ||.|||.|.    |.|..| . .. .  |.|. 
srgvsvifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlk
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 19-290 1.5e-54 178.2 In-house 10-293 (302) alignment 
Range on Protein: 19-290
Range on HMM: 10-293/302.0
VTVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPV-----------PDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLL
  . .|. .. |.| ||.....| .|||.|||.||||.|.. |..   .                ..|||||||||  |.| | |.  ||. ||..  ||
sellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyill

RGNHESRQITQSYGFYTECLNKYGGNS--RVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDR-FREIPHDGAMADLVWSDPEENNnpT
|||||.. |  .|||  |  |..| .   ..|. . ..| .. | ... . |.|||||.||.......|| |.| . |. .|    ||...|| . .  .
rgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq..l

LDHPDNSGQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQF
|  . .  .. .   ||  ..|  . |... .  ... | ||||   ||.. . |  . |..|||.|     || ..|.. .. ..
laavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkl
PP2Ac_SM00156 20-297 4.2e-101 330.5 In-house 5-269 (271) alignment 
Range on Protein: 20-297
Range on HMM: 5-269/271.0
TVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQS
 |..|. . ||.| .|.|......|||||||.|||..|.|.... .|..|...|.||||||||| .|.|.|.||. ||..||....||||||||..... 
evlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssvnki

YGFYTECLNKYggNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPeennnptldhpDNSGQHFQVSP
|||. |. .||  ...... ....|..| |....|..|.|.||||||.....|.|. ..|..|.|..| ..||.||||           ... ..|| | 
ygfeeevkrky..gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdp...........eqkekgfqpsk

RGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFEE
||....||...|..||. |....| |||....|||....|. . |..||||||....|||..|..... . ......|
rglsvvFgedavkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
subfamily_PPZ_pd Subfamily PPZ 20-283 6.6e-67 219.1 In-house 29-279 (300) alignment 
Range on Protein: 20-283
Range on HMM: 29-279/300.0
TVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQS
 .  .|.| .|... . ... .  .| .|||.|||. |.| .|   |  | .||||||||||||  |.|||.||.. |..||  . |||||||  ..|. 
eilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecanvtrv

YGFYTEClnKYGGNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEENNNptlDHPDNSgqhfqvsp
|||| ||  |   | ..|. . | |. | |..|.  .|||||||||| ....|.|. . |  ..|  | . ||.|||| ...|   .  ||         
ygfydec..krrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssn...ewedne........

RGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILE
||  | . .  ..|||    .. . ||| . ..||... |  . ||.||||||    |  ... 
rgvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavms
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 20-290 1.2e-54 178.6 In-house 10-292 (302) alignment 
Range on Protein: 20-290
Range on HMM: 10-292/302.0
TVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPV-----------PDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLR
 . .|. .. |.| ||.....| .|||.|||.||||.|.. |..   .                ..|||||||||  |.| | |.  ||. ||..  |||
ellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillr

GNHESRQITQSYGFYTECLNKYGGNS--RVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDR-FREIPHDGAMADLVWSDPEENNnpTL
||||.. |  .|||  |  |..| .   ..|. . ..| .. | ... . |.|||||.||.......|| |.| . |. .|    ||...|| . .  .|
gnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldvq..ll

DHPDNSGQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQF
  . .  .. .   ||  ..|  . |... .  ... | ||||   ||.. . |  . |..|||.|     || ..|.. .. ..
aavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkl
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 20-66 1.7e-07 23.7 In-house 15-61 (339) alignment 
Range on Protein: 20-66
Range on HMM: 15-61/339.0
TVRALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGG
 .  || . .|..  |  ......|. |.||.|||| |.| .... |
elaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 23-296 2.8e-70 229.7 In-house 15-275 (281) alignment 
Range on Protein: 23-296
Range on HMM: 15-275/281.0
ALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGF
.. .. . ....|.... |..|..||||.|.||.|. ..|.. | ||.. ..|||||||||  |.|...||..||.||. || |||||||  .. . |||
nvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasvnkiygf

YTECLNKYGgnSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPeennnptldhpDNSGQHFQVSPRGA
| ||  |||    .|  .   |. | .   |.  . |.||||||.. ..|... . .  . .. | . ||.|.||           ||... .. | ||.
yvecvtkyG..eelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadp...........dnkveewkassrGs

GYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVFE
..|||..||..  .  ... | ||||.. .||..     . ||.|.||||    | |..| .  . .  .  . 
sftfGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalv
subfamily_PPPLV_pd Subfamily PPPLV 23-282 1.3e-58 191.6 In-house 4-274 (290) alignment 
Range on Protein: 23-282
Range on HMM: 4-274/290.0
ALCFKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDML----EIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQ
.|| .  ..|..| .......|. |.||.||...|.      ....|  .  ...|||||||||| .||| |  |. ||. |||...||||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

SYGFYTECLNKYGGN-SRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIK----IIDRFREiPHDGA-M-ADLVWSDPEENNNPTLDHP--D
|. ...|.  |.| .   ||. ....||.| |  .||...||||.|.   ..|  .|     |..|... . ||| .  |..||||.|... .|      
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkd.didgaplaldilwsdpaedrdlslrgelvl

NSGQHFQvSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASIL
| |  .  . || |. |.   .|.||. |... . |||.  ..|...  .| . ||.|. .||    . | ||
neGfvdn.drrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaalil
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 26-288 1.3e-71 233.9 In-house 20-272 (287) alignment 
Range on Protein: 26-288
Range on HMM: 20-272/287.0
FKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTE
 |..|.|   . ......|.|.|||.|||..|.| ||.  |  |...|||||||||||  |.| ..||  ||..|| ..|||||||| ..| . |||. |
ekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkinklyGfkee

CLNKYGgnSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREI--PHDGAMADLVWSDPEENnNPTLDHpdNSGqhfqvspRGAG
  .|..  .|...   |.|..| || ...  |.|.|||.||.....|..| . . .     ..| . ||.|.|||.. . |..   |         |.  
lkrkrq..erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfel..nki.......rais

YTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKD
  ||...|...|.  |.. | |||.. .|||. .||  . ||.||| |. .  | .... .    
vvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvsksl
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 26-287 3.4e-63 206.3 In-house 26-278 (290) alignment 
Range on Protein: 26-287
Range on HMM: 26-278/290.0
FKLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTE
 |..|.|     ......|...|||.|||. ..|. |.  |  |. ..||||||||||  |.|  .||. .|.||. ..|||||||| |.. . |||. |
ekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnrlygfkee

CLNKYggNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFR--EIPHDGAMADLVWSDPEENNNPTLDHPDNsgqhfqvspRGAG
   |   .||.|.   |.|. | ||. ..  |.|.|||.|..... . .| . . |     ..| . ||.|.||... . |..             |.  
larkr..gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkq.........rais

YTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSK
  ||.......|.   .. | |||.. .||... ||  . ||.||| |. .  |  .|...   
vvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvses
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-288 1e-55 182.1 In-house 31-282 (307) alignment 
Range on Protein: 27-288
Range on HMM: 31-282/307.0
KLKEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTEC
. . ..  |  .. |. |. ||||.|||| |....| . |  |.| |.| |||||||| |.|.|.||.. |. ||  | |||||||  .. . |||| ||
eaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkkygfyeec

LNKYG-GNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPeennnptldhpDNSGQHFQVSPRGAGYT
.         .|  .   |. | . ..|   |.|.|||||| .  .|...   .    |  | . |..|.||           | |   .. | ||.|.|
vtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadp...........dpsvfewkassrgsgft

FGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKD
||  |..   .   .. | ||||.| .|| .     . |..||| ||    |   .| .    
fgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 29-293 2.2e-61 200.8 In-house 19-270 (280) alignment 
Range on Protein: 29-293
Range on HMM: 19-270/280.0
KEMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTECLN
. ....|||..  ..|. |.||.| |..||  .|.. | ||. . .|||||||||   .| ..||..||.||  ||.|||||||.  . . |||| ||  
eaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnkiygfyvecqy

KYGGNsrVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVWSDPEennnptldhpdNSGQHFQVSPRGAGYTFGR
|||    .|  .  .|. . .. .|   ..|.||||||..  .| |. | |  |    | . ||.||||            | |. .  | ||  | ||.
kygvg..lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdpt...........nkgegwfhsirgisymfgk

SVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFN
 |||.  .  ... | ||||. ..||..     . ||.| |||| .  | |... | .. |  |.
gvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfq
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 30-295 1.1e-62 205.1 In-house 37-292 (297) alignment 
Range on Protein: 30-295
Range on HMM: 37-292/297.0
EMLVKESNVIHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTECLNK
... .. ... ...|. |.||.|||| |.| .|. ||  | .|||||||||||| .|.|||.||.  |...|. . |||||||   . . |||| || ..
dvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvnkvygfyeecqkr

YGgNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSP---NVQTIDQIKIIDRFREiPHDGAMADLVWSDPEENnnptLdhpdnSGqhFQVSPRGAGYTF
|    |..  . |.|..| |. .| ..|.|.||||||   .  |.| .. |.| .|  ... .|||.|.||       |     ||  |    ||||  |
yq.svrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierste.gkerlvadllwadpisg....l.....sg..fmenqrgagcgf

GRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKDQFYFNVF
||  | |     ... . ||||. ..||...    . |..||| || .  | |...    | |  |...
grdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeil
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 39-282 2.1e-53 174.7 In-house 3-240 (263) alignment 
Range on Protein: 39-282
Range on HMM: 3-240/263.0
IHIQTPVTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTECLNKYGGN---SR
. .|.|. ..|| |||. |.| ||.  |    |.||||||||||| .|.| ||||. |||  | ..|||||||| . | . |||..|  ...  .     
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAM-ADLVWSDPEENNNPTldHPDNSgqhfqvspRGAGYTFGRSVVEKF
|.... ..| |. ||.|.   |.|.|||.|| ....|.|. |    |  .   . .||.|.|||.. .     |..         |     ||.  |. .
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgf..epnki........raisnvfgkkevddl

LRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASIL
 .  |.. | ||||. . || .. |  . ||.||  |     | |...
ckrldidlivrahqvveygyaffadrrlitvfsasryqielcnyaavv
Metallophos Calcineurin-like phosphoesterase 44-248 3.4e-43 141.3 Pfam-A 2-197 (200) alignment 
Range on Protein: 44-248
Range on HMM: 2-197/200.0
PVTVVGDMHGQFHDM----LEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLL--IVLKLRYPSRIHLLRGNHESRQITQSYGFYTECL----------
...|.||.||...|     |....|... . ...|||||.|||| .| ||..||   ||||..| ...||||||||..... |||. |.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

----------------------NKYGGNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIkiidrfreiphdgamadlvwsdpeennnptl
                       .. .. .....  ..|..|.|. ..|  |...||.||.  .. |.|                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

dhpdnsgqhfqvsprgAGYTFGRSVVEKFLRMNDMNRIYRAHQ
                ... ||. ..||.|. ...  . |.|.
................gselfgpdalekllekygvdlvlrGHt
PPP_2 45-249 1.7e-76 249.4 In-house 1-197 (198) alignment 
Range on Protein: 45-249
Range on HMM: 1-197/198.0
VTVVGDMHGQFHDMLEIFQIGGPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTECLNKYGgNSRVWQYLTDIF
|||.||.|||..|.|..|. |.|.|...||||||||||| .|.|...||..|||.||...|||||||||..... |||..|.|.|.| ...|...|...|
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkg.gkkvykklqevf

DYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIPHDGAMADLVwsdpE-ENnnptLDHPDNSGQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRI
..| |. .||.....||||||......|||| ..|..|.|..|.. ||     | |.    | .|... .... | ||||..||..|.|..|. |... |
elLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldll....eeek....lsdpkekeellansarGagllfgpdvteelleknklkli

YRAHQL
 |||..
iRaHev
PPP_4 45-249 1.1e-72 237.3 In-house 1-196 (197) alignment 
Range on Protein: 45-249
Range on HMM: 1-196/197.0
VTVVGDMHGQFHDM-LEIFQIG-GPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTECLNKygGNSRVWQYLTD
||||||.|||..|. |.....|  | ....|.||||||||| .|.|...||. |||.||....||||||||..... |||..|.|.|   .......|.|
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek..hgkeilkklqd

IFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIP-HDGAMADLV-WSDPEennnptldhpdN--SGqhFQVSPRGAGYTFGRSVVEKFLRMN
.||.| |. .||.....||||||......|.|. |.|..|.| ..... ||  ||||.           .  .|  .. | ||||..||..|.||||. |
vfdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpr...........eaqeg..lansvrGagllFgpdvtekflekn

DMNRIYRAHQL
... | |.|.|
nlkliirshel
PPP_5_Dcr2 45-249 1e-71 234.1 In-house 1-198 (199) alignment 
Range on Protein: 45-249
Range on HMM: 1-198/199.0
VTVVGDMHGQFHDM-LEIFQIG-GPVPDTNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTECLNKYgGNSRVWQYLTD
|||.||.|||..|. |..|. |  | ....|.||||||||| .|.|...||. |||.||...||||||||..|... |||..|.|.|| ........|.|
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky.hgkkiykilsd

IFDYLVLCCIIDDEIFCVHGGLSPNVQTIDQIKIIDRFREIP-HDGAMADLV-WSDPEennnptldhpD----NsgqhFQVSPRGAGYTFGRSVVEKFLR
.||.| |. .||.....|||||||....|.... |.|..||| ..| .|||. ||||.          |         .. | ||||..||..|.||||.
vfdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdpr..........daqegc....klnseRGagllfgpdvtekfle

MNDMNRIYRAHQL
 |... | |.|.|
knnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 45-116 6.3e-07 22.1 In-house 12-79 (235) alignment 
Range on Protein: 45-116
Range on HMM: 12-79/235.0
VTVVGDMHGQFHDMLEIFQ--IGGPVPDTNYLFLGDYVDRGLYSVETIMLLivlklrYPSRIHLLRGNHESRQI
. ||||.|| . ...|...  |||  ..   ...|| ...|  |||.. ..        .  . ..||||   .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvl
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 71-296 8.7e-66 215.2 In-house 101-313 (317) alignment 
Range on Protein: 71-296
Range on HMM: 101-313/317.0
TNYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTECLNKYggNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQT
 .||||||||||| .|.| ..||. |||.|| ...||||||||| . ..||||.|. ..|  ...... .  .|  | || .....|.|.|||.| ..  
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry..saalyeafqlafnvlplcavvnkkilcmhGGiseelld

IDQIKIIDRFREIPHDGAMADLVWSDPEENNnptldhpdnsgQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPN
..|.. ..|  .||  | .|||.|.||...            .... |.||||  || . |..||.. |.. . ||||. ..||. . |  . |..|||.
lkqldklkrpldipdvGvladltwadpdaev...........kgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsaps

YCYRCGNKASILELYSKDQFYFNVFE
|| .  | |..|.. .| .  .||..
ycGqldniaavlsvdkklkisinvlr
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 72-297 5.8e-55 179.7 In-house 121-333 (339) alignment 
Range on Protein: 72-297
Range on HMM: 121-333/339.0
NYLFLGDYVDRGLYSVETIMLLIVLKLRYPSRIHLLRGNHESRQITQSYGFYTECLNKYggNSRVWQYLTDIFDYLVLCCIIDDEIFCVHGGLSPNVQTI
 ||||||||||| .|.| ..||  ||| || ||.||||||||| .  ||||| |   .|  ...... . ..|. . .|..|.. |.|.|||.|  . ..
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry..daqlyecfqnmfnvfpfcavinntimcmhggisehltsf

DQIKIIDRFREIPHDGAMADLVWSDPeennnptldhpDNSGQHFQVSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIyFDG-LVTTVWSAPN
.|. .. |  |||  | ..|| |.||           | . . .. | ||| . ||   .  ||.  |.. . | ||. ..||.. |||  . |..||||
nqfsvfkrpleipdvgvltdltwadp...........dptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyef.fdgrrlvtifsapn

YCYRCGNKASILELYSKDQFYFNVFEE
|| .  | |... .  | .   |||  
ycgqndntaavfsidkklkisinvfrp
subfamily_PPP7C_pd Subfamily PPP7C 189-298 1.4e-12 40.1 In-house 237-335 (383) alignment 
Range on Protein: 189-298
Range on HMM: 237-335/383.0
MADLVWSDPEENNNPTldhPdNsgqhfqvSPRGAGYTFGRSVVEKFLRMNDMNRIYRAHQLCNEGYQIYFDGLVTTVWSAPNYCYRCGNKASILELYSKD
. |..||||....  .   | |       . ||.|  ||  | .|.|.  ... . |.|.   |||..  |  | |..|| ||     |. . . | .. 
vldilwsdpkakeGck...p.n.......tlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdl

QFYFNVFEEA
. ..  .  .
tprivqyqas