Gene ALP-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold AP
Superfamily AP
Family AP
Subfamily AP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP001_AA protein Get Run
SpurP001_AA_28-499 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_AP_pd Subfamily AP 29-500 9.3e-204 668.0 In-house 3-468 (472) alignment 
Range on Protein: 29-500
Range on HMM: 3-468/472.0
APYWNLKGRAAVEEALLRQrLNVNIAKNIIFFLGDGLDVTTTTAARIRKGQLAGGMGEEASLHFEHFPHVGLVKTYNTDRQVPDSAGTATAYLCGVKSKF
| .|. |......||| .|  | . |||.|.|||||..|.|.||||| ||||.|..||||||..|.||.|||.|||..|.||||||.||||||||||...
akfwlkkaqeelkealelq.snskkakNvilflgdGmgvstvtaaRilkgqlkgelgeeasLaleeFpyvglsktyssdkqvpdsaatAtAylcGvktnn

GTLGVDDRVERGKCTSIEGAAVDSILIDSMKAGKSTGLVSTARVTHASPAALYAHTPDRRWENDHDLDDRDKREGCKDIALQLI--EHGKNMNVIMGGGR
||.|||..|||..|.. .|  |||||  ..||||.||||.|.||||||||.||||...|.||.|.........||||||| |||  |.||...||.||||
gtiGvdaaverkdCeasagkevdsileaAkkaGkatGlVtttrvthAsPaglyahvanRnwesdeevpaeaekegckdiaqQLieeevgkeldvilGGGr

RELTPRNVEDPEYDGDyGQRLDGRNLIEDWleDKDPMRSHYVWNLQDFNRVNAETTDHLIGLFQPSHMKYETDRrwDRAGEPSLAQMTEKAIKILQRtSD
....|..|.|.||. . |.| |||||||.|  .|.  ...||.| .....|....||.|.|||..||.|||.||  |...||||..|||||...|.. ..
kkflpktvkdseyekk.gerkDgrnLieew..ekekknakyvenrkelenvdksktdrllGlfadshlkyeidr..dekeePsLkemtekAlevLsk.ne

NGFFLFVEAGRIDHGHHDGMALDALTETLALDEAIGVALRLTSAEDTLIVSTADHAHVMTMAGYASRGNPILGLEDHYLADDDLPYATLSYANGPGARHM
||||||||.|||||.||...| .||.|||..|||. .||.||. ||||||.||||.|..|.|||..||..||||...  ..|.|||.|||||||||....
nGffLfVEggrIDhahhenkakkaleetlefdeavelaleltdeedTlivvtaDHshtltiagypkrgssilglakesksadelpyttlsyangpgyelt

ASSFQKhGARENLTSVDTEETGHRQQALVPFDEETHGGQDVMVYARGPMAHLFHGVQEQSYIPHVIRYAACLAG
 |. .. |.|..||...||.. ...||.||..||||||.||.|||.||..||..||.|||.|.||..|||||  
esdlee.gerkdlteaeteakdyvsqaavpleeetHggeDvavyasGpqshlltGvveqstiahvmayaaclge
0037220 Alkaline phosphatase-like 29-499 2.3e-153 501.4 In-house 9-469 (479) alignment 
Range on Protein: 29-499
Range on HMM: 9-469/479.0
APYWNLKGRAAVEEALlRQRLNVNIAKNIIFFLGDGLDVTTTTAARIRKGQLAGGMGEEASLHFEHFPHVGLVKTYNTDRQVPDSAGTATAYLCGVKSKF
. ...|   |.. .|| .. || . |||.|.|.|||..|.|.||||| .||| ||.|||  |....||.|||||||..|..|.|||..|||...|||. .
lllllllalallllal.llllnkskaknvilfigDGmgvstvtaariylgqllgglgeegllaldkfplvglvkTysvdslvtDSAaaaTAlatGvKtnn

GTLGVDDRVERGKCTSIEGAAVDSILIDSMKAGKSTGLVSTARVTHASPAALYAHTPDRRWENDHDLDDRDKREGCKDIALQLIeHGKNMNVIMGGGRRE
|..|||  |.|..|..  |  |..||    .|||.||||.|.|.|||.|||.|||...| ||.| .|.  . ..|||||| ||. .|....||.||||. 
gaigvdadvsrdncddplgnpvetilelakeaGkatGlVtTtrithATPAafyAhvanRnweddialqllgleagckdiatqlv.lgsgldvilGGGrky

LTPRNVEDPEYDGD---YGQRLDGRNLIEDWLEDKDPmrSHYVWNLQDFNRVNA-ETTDHLIGLFQPSHMKYETDRrwDRAGEPSLAQMTEKAIKILQRt
..| .. ||||| .    |.|||||.|.| . | |.    .||.|..... ... ...|.|.|||..||..|| ||  | ..|||||.|||||...|.. 
flpkgtldpeydlelllggkrldgrdlleeakekkkg..ytyvtnreeldaldlgsnvdkllGlfadshlpyeldr..daseePsLaemtekAldlLsk.

SDNGFFLFVEAGRIDHGHHDGMALDALTETLALDEAIGVALRLTSAEDTLIVSTADHAHVMTMAGYASRGNPILGLEDHYlADDDLPYATLSYANGPGAR
.|.||||.||.|||||..|.. |  ||.|.||.|||...||.... .|||.| |||| |.... |||.|||||||| ... . |.|||.||.||||||  
ndkGFfLmvEggriDhagHandaaaalgevlafdeaveaalefakdddTlvvvtADHshgglilgyadrgnpilgllpgl.lldglpyttllyangpgfl

HMASSfqkhgaRENLTSVDTEETGHRQQALVPFDEETHGGQDVMVYARGPMAHLFHGVQEQSYIPHVIRYAACLA
.. .       |..|| ..| .   .|.|||... ..|.|.||.|||.||.|.||.||.|...|.|||..|..| 
llldl......rldltllvtlallllqralvgwtsggHtgedVpvyayGpgaelflgvyentdiahviasalglg
Alk_phosphatase Alkaline phosphatase 54-498 9.3e-143 466.7 Pfam-A 1-421 (421) alignment 
Range on Protein: 54-498
Range on HMM: 1-421/421.0
AKNIIFFLGDGLDVTTTTAARIRKGQLAGGMGEEAsLHFEHFPHVGLVKTYNTDRQVPDSAGTATAYLCGVKSKFGTLGVDdrvergkctsIEGAAVDSI
|||.|...|||. |.|.||||. |.| .| .|||. |.....|.||| |||..|.||.|||.|||||.||||.  |..|||           .|  | |.
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

LIDSMKAGKSTGLVSTARVTHASPAALYAHTPDRRWENDHDLDDRDKREGCKDIALQLIEHGKNMNVIMGGGRRELTPRNVEDPeyDGDYGQRLDGRNLI
|    |||||||||.|.|||||.||||.||. .|.||.| .  .  |.||.|||| |||.  |...|..||||.|. |.. .|.   .. | ||||||||
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde..ekerGtrldgrnli

EDWledkDPMRSHYVWNLQDFNRVNAET-TDHLIGLFQPSHMKYETDRRwdRAGEPSLAQMTEKAIKILQRTSdNGFFLFVEAGRIDHGHHDGMALDALT
|..        ..||.. ....... |  ...|.|||.....|.| .|.   . ||||..|||.|||.|.. . .||||.|| .||||..|.. |  ||.
eea....kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerd..ekeePsLkemtevAiklLskne.kGFFLlVEGsrIDhaaHendavgals

ETLALDEAIGVALRLT-SAEDTLIVSTADHAHVMTMAGYASRGNPILGLEDHYLADDDLPYATLSYANGPGARHMAssfqkhGARENLTSVDTEETGHRQ
|....|||.  || .. . ..||.|.||||.||....||  ||. | ||      .|  ..  ..|.||.||.         |||||.|  .. |. .|.
EvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakved......garenvtaeealekiyrk

QALVPFDEETHGGQDVMVYARGPMAHLFHGVQEQSYIPHVIRYAACL
.. |....|.|.|.|| |.|.||.|.|..||||| .|..|. .|..|
rsavgltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel
Alk_phosphatase Alkaline phosphatase 54-498 9.3e-143 466.7 In-house 1-421 (421) alignment 
Range on Protein: 54-498
Range on HMM: 1-421/421.0
AKNIIFFLGDGLDVTTTTAARIRKGQLAGGMGEEAsLHFEHFPHVGLVKTYNTDRQVPDSAGTATAYLCGVKSKFGTLGVDdrvergkctsIEGAAVDSI
|||.|...|||. |.|.||||. |.| .| .|||. |.....|.||| |||..|.||.|||.|||||.||||.  |..|||           .|  | |.
aknvilligDGmgvstvtaaRslkeqakgklgeei.laldrlplvglsktyavdkqvtDSaataTAyacgvktyngaigvd..........thgkevksv

LIDSMKAGKSTGLVSTARVTHASPAALYAHTPDRRWENDHDLDDRDKREGCKDIALQLIEHGKNMNVIMGGGRRELTPRNVEDPeyDGDYGQRLDGRNLI
|    |||||||||.|.|||||.||||.||. .|.||.| .  .  |.||.|||| |||.  |...|..||||.|. |.. .|.   .. | ||||||||
leaAkkaGkstGlVtTtrvthAtPaalvahvasRkweddaataasakkeGkkdiaeqlikakkkidvllGGGrkeflptgtkde..ekerGtrldgrnli

EDWledkDPMRSHYVWNLQDFNRVNAET-TDHLIGLFQPSHMKYETDRRwdRAGEPSLAQMTEKAIKILQRTSdNGFFLFVEAGRIDHGHHDGMALDALT
|..        ..||.. ....... |  ...|.|||.....|.| .|.   . ||||..|||.|||.|.. . .||||.|| .||||..|.. |  ||.
eea....kkagyqyvsdrkeLlkakeensvkplLGLFadgdlkvelerd..ekeePsLkemtevAiklLskne.kGFFLlVEGsrIDhaaHendavgals

ETLALDEAIGVALRLT-SAEDTLIVSTADHAHVMTMAGYASRGNPILGLEDHYLADDDLPYATLSYANGPGARHMAssfqkhGARENLTSVDTEETGHRQ
|....|||.  || .. . ..||.|.||||.||....||  ||. | ||      .|  ..  ..|.||.||.         |||||.|  .. |. .|.
EvvefdeAvkaalefakkeketlvvvTaDHshvfsiggytqrgtsieglaaakktkdgkakklilygngegakved......garenvtaeealekiyrk

QALVPFDEETHGGQDVMVYARGPMAHLFHGVQEQSYIPHVIRYAACL
.. |....|.|.|.|| |.|.||.|.|..||||| .|..|. .|..|
rsavgltseeHtgedvavfAygpkaelvrGvqeqteiakvlaaalel