Gene LMWPTP in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC2
Superfamily CC2
Family LMWPTP
Subfamily LMWPTP
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP122_AA protein Get Run
SpurP122_AA_6-155 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LMWPTP_pd Subfamily LMWPTP 7-155 1.4e-68 219.5 In-house 2-151 (152) alignment 
Range on Protein: 7-155
Range on HMM: 2-151/152.0
KSVLFVCLGNICRSVTSEALFRQLAEEKGFASDWKIDSAATSTYQIGDEPDSRTNQTLEKMGRKRSkHIARQITKQDFKDFQYIFGFDQSNISNINRVKP
|.||||||||||||...||..|.| |.||...|||.||||.|.|..|.|||.|....|.|.|.|.| |.||||||.||..|.||...|.||.........
kkvlfvClGniCrspiaEavlrklvekkglkedwkvdsaaissyhvGkepdkRalsilkkhglkss.hrarqitkedfsefdyilamDesnlkelkklak

--KDSKSQVLLMGKYGKNGDEIVEDPYYHDMAAFDTMYEQCDRCVRAFIAE
  |.||..|||.|.|.|.|.||.|||||.|...|...|.|...|..||...
ekkeskakvlllgeydkkgkeiiedpyygdekdFeavykqikecckaflkk
0046251 Phosphotyrosine protein phosphatases I 7-155 1e-45 145.9 In-house 6-157 (159) alignment 
Range on Protein: 7-155
Range on HMM: 6-157/159.0
KSVLFVCLGNICRSVTSEALFRQLAEEKGFASD-WKIDSAATSTYQIGDEPDSRTNQTLEKMGRKRSkHIARQITKQDFKDFQYIFGFDQSNISNINRVK
|.|||||.|||||| . |||.|.|.|..|.... . .|||.||....|..||.|. ..|...| . | |.|||.|..||..| .|.. |.||.... |. 
kkvlfvCtgNicRSpmAeallrhlledaglsdllievdSaGtsalhvgeppdpravavlkelgidls.hrarqlteedfeefdlilamddsnlrdllrla

PKDSKSQVLLMGKYGKNGD---EIVEDPYYHDMAAFDTMYEQCDRCVRAFIAE
|.|....|||.... .. .     |.||||....||....... ..|.|....
pgdargkvllllefagllellhwdvpDPyyggleaFeevldlieeaveallek
0053360 Phosphotyrosine protein phosphatases I 7-155 5.8e-45 143.3 In-house 6-155 (157) alignment 
Range on Protein: 7-155
Range on HMM: 6-155/157.0
KSVLFVCLGNICRSVTSEALFRQLAEEKGFASDWKIDSAATSTYQIGDEPDSRTNQTLEKMGRKRSkHIARQITKQDFKDFQYIFGFDQSNISNINRVKP
|.|||||.|||||| ..|||.|.|.||.|..... .||| ||....|...|.|. ..|...| . | |.|||.|..|...| .|.  |.||.... .. |
kkvLfvCtgNicRSpmAeallrhlleeaglgdrfevdSaGtsalhvggpvdpravevlaelgidls.hrarqlteedleefdliltmddsnleellplfp

K--DSKSQVLLMGKYGKNGDEIVEDPYYHDMAAFDTMYEQCDRCVRAFIAE
.  ..|..|||.... .  .  |.||||....||....... ..|.|....
glleakgkvllllefagllhwdvpDPyyggleafelvldlieeaveallel
0048765 Phosphotyrosine protein phosphatases I 7-155 8.5e-45 142.7 In-house 3-152 (154) alignment 
Range on Protein: 7-155
Range on HMM: 3-152/154.0
KSVLFVCLGNICRSVTSEALFRQLAEEKGFASDWKIDSAATSTYQIGDEPDSRTNQTLEKMGRKRSkHIARQITKQDFKDFQYIFGFDQSNISNINRVKP
|.|||||.|||||| ..|||.|.|.||.|..... .||| ||.| .|...|.|. ..|...| . | |.|||.|..|...| .|.  |.||.... .. |
kkvLfvCtgNicRSpmAeallrhlleeaglgdrvevdSaGtsayhvgepvdpravevlaelgidls.hrarqlteedleefdliltmddsnleellplfp

K--DSKSQVLLMGKYGKNGDEIVEDPYYHDMAAFDTMYEQCDRCVRAFIAE
.  ..|..|||.... .  .  |.||||....||....... ..|.|....
glleakgkvllllefagllhwdvpDPyyggleafeevldlieeaveallel
0042188 Phosphotyrosine protein phosphatases I 7-155 6.2e-39 123.6 In-house 5-142 (146) alignment 
Range on Protein: 7-155
Range on HMM: 5-142/146.0
KSVLFVCLGNICRSVTSEALFRQLAeekgfASDWKIDSAATSTYQIGDEPDSRTNQTLEKMGRKRSKHIARQITKQDFKDFQYIFGFDQSNISNINRVKP
|.|||||.|||||| . |||.|.|.     .. . .||| ||.| .|...|.|. ..|...| . |.|.|||.|..|...| ...  |.||.... .. |
kkvlfvCtgNicRSpmAeallrhll.....gdrvevdSAGtsayhvgepvdpravevlaelgidisghrarqlteedleefDlvltmddsnlrdllplfp

KDSKSQVLLMGKYGkngdeIVEDPYYHDmAAFDTMYEQCDRCVRAFIAE
. .|. |||....       |.||||..  ||....... ..|.|....
gaakgkvllllefw.....dvpDPyygg.eafeevldlieeavkallel
LMWPc_SSU72_ArsC 7-145 3.2e-34 108.5 In-house 1-126 (126) alignment 
Range on Protein: 7-145
Range on HMM: 1-126/126.0
KSVLFVCLGNICRSVTSEALFRQLAEEkgfasDWKIDSAATSTYQIGDEPDSRTNQTLEKMGRKRSkHIARQITKQDFKDFQYIFGFDQSNISNINRVKP
|.|||||||||||| ..||........     .....||.|.... |...|||....|...| . . | .||....|.|.|..|...|..| ... .  |
kkvlfvClgNicRSpmAeavlkkavkk.....glnvsSaGtgaavpgksidsravellkengielk.hkprqlqeedlkefdliltmdernkdevlellp

KDSKSQVLLMgkygkngDEIVEDPYYHDMAAFDTMYEQC
.. ...| |.       .  |.|||.... .|  .....
eratkkvhll.......nldvkDpyegaesgfeevldli
0047618 Phosphotyrosine protein phosphatases I 7-154 6.7e-32 100.5 In-house 2-134 (137) alignment 
Range on Protein: 7-154
Range on HMM: 2-134/137.0
KSVLFVCLGNICRSVTSEALFRQLAEEKgfasdWKIDSAATSTYQigdePDSRTNQTLEKMGRKRSKHIARQITKQDFKDFQYIFGFDQSNISNINRVKP
|.|||||.|||||| ..|||.|.|....     ...||| |....    .|.|. ..|...| . |.|...|....|...| ...  |.|..... .. |
kkvlfvCtgNicRSpmAeallrhllgdr.....vevdSAGtepag....vdpravevlaelgidisghrskqldeldlpefdlvltmddsalealpllap

KDSKSQVllmgkygkngdeIVEDPYYHD------MAAFDTMYEQCDRCVRAFIA
.     .             |.|||| .      ..||..........|.|...
aalrlhw............dvpDPyygggteeekleafervldlieervealle
0047572 Phosphotyrosine protein phosphatases I 7-153 2.3e-29 92.2 In-house 3-128 (130) alignment 
Range on Protein: 7-153
Range on HMM: 3-128/130.0
KSVLFVCLGNICRSVTSEALFRQLAeekgfASDWKIDSAATStyqiGDEPDSRTNQTLEKMGRKRSKHIARQITKQDFKDFQYIFGFDQSNISNINRVKP
|.|||||.||.|||. .|||.|.|.     .......|| |.    |...|.|. ..|...| . |.|...|........| ...  |.|..... .. |
kkvlfvCtgNscRSpmAeallrhll.....gdrvevySAGte....gsgvdpravevlaelgidisghrskqldelllpefdlvitmddsalealpllap

KDSKSQVllmgkygkngdeIVEDPYYHDMAAFDTMYEQCDRCVRAFI
.     .             ..|||. ...||........|.|.|..
aalrlhw............dipDPygggleafrevrdlierrvlall
0051181 Phosphotyrosine protein phosphatases I 8-153 2.4e-31 98.6 In-house 1-122 (124) alignment 
Range on Protein: 8-153
Range on HMM: 1-122/124.0
SVLFVCLGNICRSVTSEALFRQLAEEkgfasdWKIDSAATstyQIGDEPDSRTNQTLEKMGRKRSkHIARQITKQDFKDFQYIFGFDQSNISNINRVKPk
.|||||.||||||...|||.|.|...      ...||| |   ..|...|.|. ..|...| . | ....|....|...| ... .|.||. .. .  | 
kvlfvCtgNicRSpmAeallrhllgd......vevdSAGt...hpggpvdpravevlaelgidls.lrskqldeldleefdlvltmddsnlcpllplap.

dsksqvllmgkygKNGDEIVEDPYYHDMAAFDTMYEQCDRCVRAFI
             .  .  |.||||.....|..........|.|..
.............lllhwdvpDPyyggleefeevldlieerveall
LMWPc_SSU72 8-155 4.4e-29 92.1 In-house 2-137 (137) alignment 
Range on Protein: 8-155
Range on HMM: 2-137/137.0
SVLFVCLGNICRSVTSEALFRQLAEekgfasDWKIDSAATSTYQIGDEPDSRTNQTLEKMGRKRSkHIARQITKQDFKDFQYIFGFDQSNISNINRVKPK
.|||||..||.||. .|||... .|       ....|| |... .|...| ........ | . . . ...........| ... ...... ....  |.
kvlfVCasNinRSmeAeallkeale......glevkSaGtgslvpgpsidkpaeelykenGlsik.eapeklqeeelekfDlvitleervfdavvedlpe

D--SKSQVLLMgkygkngDEIVEDPYYHDMAAFDTMYEQCDRCVRAFIAE
   .|..|...       .  ..||.......| .........|....||
rselkrkvhvi.......nvdikDpheeaiegfkaildlieervkellae
LMWPc Low molecular weight phosphotyrosine protein phosphatase 9-153 8.4e-42 133.3 Pfam-A 1-138 (138) alignment 
Range on Protein: 9-153
Range on HMM: 1-138/138.0
VLFVCLGNICRSVTSEALFRQLAEEKgFASDWKIDSAATSTYqIGDEPDSRTNQTLEKMGRKRSKHIARQITKQDFKDFQYIFGFDQSNISNINRVKPKD
|||||.|||||| ..|||.|.|.|..  . ....|||.|. . .|...| |. ..|...| . |.|.|||......|.| .|. .|.........|.|. 
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvapek

SKSQVLLMGKygkngDEIVEDPYYHDMAAFDTMYEQCDRCVRAFI
....| |.|.     .  ..|||......|....... ..|....
keakvvllge.....qwdipDPygkeeeefeevrdeieervkkll
LMWPc Low molecular weight phosphotyrosine protein phosphatase 9-153 8.4e-42 133.3 In-house 1-138 (138) alignment 
Range on Protein: 9-153
Range on HMM: 1-138/138.0
VLFVCLGNICRSVTSEALFRQLAEEKgFASDWKIDSAATSTYqIGDEPDSRTNQTLEKMGRKRSKHIARQITKQDFKDFQYIFGFDQSNISNINRVKPKD
|||||.|||||| ..|||.|.|.|..  . ....|||.|. . .|...| |. ..|...| . |.|.|||......|.| .|. .|.........|.|. 
vlfvCtgNicRSpmAeallralleka.lgdkvevdSAGteal.vgesvdpravevlkekgidisghrarqlseeelkefDliltldeeaarelcpvapek

SKSQVLLMGKygkngDEIVEDPYYHDMAAFDTMYEQCDRCVRAFI
....| |.|.     .  ..|||......|....... ..|....
keakvvllge.....qwdipDPygkeeeefeevrdeieervkkll