Gene SpurPPP-Un-1 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP150_AA protein Get Run
SpurP150_AA_579-771 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PDZ_1 PDZ-like domain 48-99 2.7e-06 13.8 Pfam-A 4-57 (78) alignment 
Range on Protein: 48-99
Range on HMM: 4-57/78.0
SASFVKTAGALLQDLPVQATLESVLKVTFSVVNKPDFQRELRK--KRIFVISLL
  .||. ||| ..||. |. .   ..|   .|...  . .| .  |. ..|. .
pdrfvevaGatfhdLsyqqaRsyaipvkgvyvseasgsfslaskekkgviitsi
EF-hand_7 EF-hand domain pair 243-326 2.6e-09 27.0 Pfam-A 6-65 (66) alignment 
Range on Protein: 243-326
Range on HMM: 6-65/66.0
FRSFDSKRQGYLDPEDFINCPMTLAFDSKrqgyldpedfinglaamqpsapHGGLPAelRCRYIFRYYDQNRHGKMEFTGFKQM
|...|. . ||||.|.. .    |  . .                      .....    ..|||...| |. |.. |. | |.
FkllDkdgdgyldkeeLlrllkhlgspli......................deevre..vldyifkeiDkngdGvlsfeEflqa
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 570-770 2.1e-36 118.5 In-house 9-197 (290) alignment 
Range on Protein: 570-770
Range on HMM: 9-197/290.0
SWGTVEMLSLaKCLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCFEKALWRMgPlltPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDK
 .|... .|  | .| . .... .|   | |....||  |.||.||.. .|. . .|. .  |      ||||||||||| . .||  .||  ||. . |
kygvldafsd.kdileilekieeileplpalleveapivivgdihgqldallryfdavgyp.p...kvkflflgdyvdrgakslevslllfcykiryskk

FFMIRGNHELRPVQKMFHFEAECTQKFGAtigqQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEGGVCSLAEINKIPVPLkdpENESQLAWELMWND
  ..||||| | |.... |  | ..| |.    ..|   .  |. ... | |..||.| |||. .      ||  ..|  |||   . .  |  .|.| |
vhllrgnhevrkvnrlygfkeelarkrgs....rlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpl...tcdeglqvdllwad

P
|
p
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 571-770 3.3e-43 140.7 In-house 4-191 (287) alignment 
Range on Protein: 571-770
Range on HMM: 4-191/287.0
WGTVEMLSLaKCLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCFEKALWRMgpllTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKF
.|... .|  | .| . .... .|   | |....||  |.||.||...||. . .|  .     .   .|||||||||| . .||. .||| ||. | | 
ygvldafsd.kdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaa....pkvqylflGdyvdrGakslevslllfslkiaypkkv

FMIRGNHELRPVQKMFHFEAECTQKFGatigQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPENESQLAWELMWNDP
 ..|||||.. . |.. |..| ..|..    .....  |  |. .|. | |...|.| |||. .    . || ... .. | .. . .  |  .|.| ||
hllrGnhevkkinklyGfkeelkrkrq....erlykqfndvfselplcarvskrilcmhGGispk...lksldslkalkkpttplacdeglqvdllwadp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 577-622 6.3e-07 21.8 In-house 8-53 (317) alignment 
Range on Protein: 577-622
Range on HMM: 8-53/317.0
LSLAKCLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVC
|  .| |. ||  |. .. .||  ..|.||  |.||.||.|.||. 
lfkekelielcyrarelfwkeplkleleapvtivGdihGqfedlla
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 578-622 2.4e-07 23.1 In-house 11-55 (339) alignment 
Range on Protein: 578-622
Range on HMM: 11-55/339.0
SLAKCLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVC
  |  |  ||. |. ..  || ..||.||  ..||.||.| ||..
fcaaelaelchrareliwsepiflkleapicvmgdihgqfddlla
0045823 Metallo-dependent phosphatases 580-770 8.2e-51 166.2 In-house 45-222 (473) alignment 
Range on Protein: 580-770
Range on HMM: 45-222/473.0
AKCLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCfekaLWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHEL
...|| |..||. .|..|| |..|.......||.||...||      | ..  .  .  ..||||.|||| ...||. .|.. ||..|...|..||||||
eedllklldeakeilkkepnllelsmrivviGDiHGqlddLlr....llekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrGNHEl

RPVQKMFHFEAECTQKFGATigqqVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEggvCSLAEINKIPVPLKDPEneSQLAWELMWNDP
| .  .. |  |. .|.|.     ..|... .....|.|||...||...|||.. .     .| .|..|. ||  |.  ..|...|.|.||
rllnglygfgdetlekyged....lyeeflewlrslPlaaviggkilfvHGGlspdl...plldqireierpleipd..dgllldllwsdP
subfamily_PPP7C_pd Subfamily PPP7C 580-735 1.3e-26 86.2 In-house 35-190 (383) alignment 
Range on Protein: 580-735
Range on HMM: 35-190/383.0
AKCLLALCREAQRVLANEPRLIKLNAP----TYILGDLHGNFHDLVCFekaLWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRG
|| .| . |||..|| . | . ....       . |||||.. ||.     |.. |   .  ...| ||.||||...||..  |..  .. | .... ||
akyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddllli...lyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrG

NHELRPVQKMFHFEAECTQKFGAtIGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNS
|||   .   . |  | ..|.    |... . ..  |  .|.|...|.||.  |||. ..
nhedhilnlryGfikeveskykv.hgkkilrlledvfawlplatlidekilivhGGisdk
PP2Ac_SM00156 581-770 6.9e-53 172.4 In-house 4-180 (271) alignment 
Range on Protein: 581-770
Range on HMM: 4-180/271.0
KCLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCFEkalWRMGpLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELR
...|.|..|....| .|. |....|| .. ||.||...||. .     . |   .   ..|||||||||....||| .||. ||| |.|... ||||| .
eevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrll...elag.eppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEss

PVQKMFHFEAECTQKFgatiGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNsegGVCSLAEINKIPVplKDPENESQLAWELMWNDP
.|.|.. || |. .|     |....| .. .|...|.||.||.||.| |||...    . || .|.|.     . . |..|...|.|.||
svnkiygfeeevkrky....gkeiyekfeeafsllPlaalvdskilcmhGGlsp...eleslddirklkr..vkekpeegllidllwsdp
0053225 Metallo-dependent phosphatases 581-770 1e-46 152.9 In-house 25-202 (293) alignment 
Range on Protein: 581-770
Range on HMM: 25-202/293.0
KCLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLvcfeKALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELR
. || |. ||...| .|| |..|....|..||.|||..||    .||...  .  .  ..||||.|||| ...||. .|.. |.|.||.....||||||.
eelllllleakeilkkepnllelsmriyviGDiHGnlddL....lallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllrGNHElm

PVQKMFHFEAECTQKFGatiGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEGgvcSLAEINKIPVPLKDPENesQLAWELMWNDP
 .. ...| .|. .|.|   ....|.... .....|.||....||...|||.. .     .| .|..|  ||  |..  .| ..|.|.||
llnglygfgdetlrkyg...aaelwdelldwlrslplaaliggkilfvHgGlspdls...lldqireinrplriple..gllldllwsdp
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 581-770 1.4e-40 132.5 In-house 11-193 (284) alignment 
Range on Protein: 581-770
Range on HMM: 11-193/284.0
KCLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVC-FEKALWR-MGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHE
| |. ||  |. .. .|.  ....||  | ||.||.| ||.  ..   |  .        .|||||||||| . .|||. ||. |.| ||| |..|||||
kelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrgnhe

LRPVQKMFHFEAECTQKFGATigqqVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNsegGVCSLAEINKIPVPLKDPEneSQLAWELMWNDP
 |||.. . | .|| ...  .    ..||.. .| |||..|||..||.| |||...   .. .| ...|.  |.  |.    .  .| | ||
srpvnmqygfyleckkrysea....lyeafqlafnamplcavvskkiicmhggise...dlldlkqldklerpidipd..igviadltwadp
subfamily_PPP5C_pd Subfamily PPP5C 581-770 1.7e-35 115.6 In-house 37-219 (322) alignment 
Range on Protein: 581-770
Range on HMM: 37-219/322.0
KCLLALCREAQRVLANEPRLIKLNAPT----YILGDLHGNFHDLVC-FEKalwrMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRG
|. |..  ||...| ..| |.... ..     . ||.||.|.||.  ||.     |   .  ..|| ||.|||| . ||||  |.. |.| |..||. ||
kyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifel....nGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrG

NHELRPVQKMFHFEAECTQKFGatigQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEGgvCSLAEINKIPVPLKDPENESqlAWELMWNDP
|||   . |.. || |...|.     ..| .  .  |. .|.| |...|..  |||.....|   .| .. ||    ..||..     ||.| ||
nhesdnmnklyGfegevkakyt....ekvadlftevfnwlPlahvinekvlvvhGGlfsedg..vtlddlrkidrnaqppeegl..lvellwsdp
subfamily_PPPLV_pd Subfamily PPPLV 582-770 1.2e-78 257.4 In-house 1-188 (290) alignment 
Range on Protein: 582-770
Range on HMM: 1-188/290.0
CLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCFEKALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRP
.||.||  | ..||.| ||..|..|||.|||||||..||..||| |||.|. |||.|.||||||||||...||.||||...|.| | |....||||||. 
lllslcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnheles

VQKMFHFEAECTQKFGATIgQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEGGVCSLAEINKIPVPLKDPENESQLAWELMWNDP
||. ... .|.. ||| .. ..||||.| .|||.|.|||.|.|.||.|.|.|..  . . .. |..|.  |||. . . ||....|.||
vqesieykgegsfkfgdsl.eevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdp
0049330 Metallo-dependent phosphatases 582-771 6.5e-49 159.9 In-house 34-210 (309) alignment 
Range on Protein: 582-771
Range on HMM: 34-210/309.0
CLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCfekaLWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRP
 || |. .|...| .|| |..|...... ||.||...||      | ..  .  .  ..||||.|||| ...||. .|.. |.|.||..|..||||||| 
ellllllkakeilksepnllelsmrivviGDiHGqlddLlr....llekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfllrGNHElrl

VQKMFHFEAECTQKFGatigQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEggvCSLAEINKIPVPLKDPENesQLAWELMWNDPL
.. ...|  |. .|.|    ...||... .....|.|||...||.|.|||....     .| .|...  ||  |.   .| ..|.|.|||
lnglygfgdetlrkyg....aelweefldwlrslplaaviggkilcvHgGlspdl...llldqirelerpleipld..gllcdllwsdpl
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 582-770 2.1e-36 118.7 In-house 28-204 (299) alignment 
Range on Protein: 582-770
Range on HMM: 28-204/299.0
CLLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVC-FEKAlwRMGPlltPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELR
 |  ||. |..|.|... |....||  . ||.||.. ||.  |.||  .. |      |||||||||||   .|.|. |.  ||  |..|||.|||||  
elqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdka..gfpp...dvnflflgdyvdrgrqnlelitlllcfkikyperffmlrgnhecp

PVQKMFHFEAECTQKFGATigqQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPlKDPENESqLAWELMWNDP
 ..... |  || ... .|   ..| ... .|.|||.. .. ..|.| |||.      . .|  . ... | .|| | | |  .|.| ||
ainrvygfyeecnkrykst...rlwsifqdafaampltgligsrilcmhgglspk...lqtldqlrdltrp.qdppnps.lgidllwadp
subfamily_PPP1C_pd Subfamily PPP1C 583-770 3.4e-49 160.5 In-house 15-189 (282) alignment 
Range on Protein: 583-770
Range on HMM: 15-189/282.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCFEKAlwrmGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPV
. ||...|...| ..| |..|.||  |.||.||...||. . ..    .   .  ..||||||||||....|.|. |.. ||  |...|..|||||   .
ieallkkareillsqpilleleaPvkivgdihGqyadllrlfet....sgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhesasi

QKMFHFEAECTQKFGATigqqVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPENesQLAWELMWNDP
.... |  || ......    .|.... .|. .|.||.||.||.| |||. ..   . || .|.||  ||. ||.   |. .|.| ||
nriyGfydeckrrysik....lWktftdvfnclPlaalvdekilcvhGGlspe...lksleqirkiqrPlevpek..gllcdllWsdp
PPP_3 583-747 3.5e-49 160.2 In-house 7-164 (271) alignment 
Range on Protein: 583-747
Range on HMM: 7-164/271.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCFEKalwrMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPV
|  |.......| .|. |....||  ..||.|| ..||. ..|    .|      ..||||||||||....||. .|.. ||. |......||||| | .
lkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfk....nggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrqi

QKMFHFEAECTQKFGatiGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEGGVCSLAEINK
 |.. |. |...| |   |..|..... .|...|.||..|.|....|||. .|   . .. ....
nkvYgFkkevlkkkg...gkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikkler
PPP_1 583-736 5.2e-45 146.8 In-house 6-152 (264) alignment 
Range on Protein: 583-736
Range on HMM: 6-152/264.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCfekaLWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPV
| .|.......| .|. |......  . ||.||.|.||.     | ..|      ..||||||||||.. ||.. .|.. |.  |...|..||||| | |
laelkkklkellnkeenllevseeitvcGDiHGqfdDLlk....lfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

QKMFHFEAECTqkfGATIGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSE
 |.. |. |.      . ........  .|| .|.||..|.||.. |||. .. 
tkvygFkkEvl...kkkyskeiyktltdvFdvLplaalidekilivHGGlspel
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 583-770 3e-43 141.0 In-house 29-204 (298) alignment 
Range on Protein: 583-770
Range on HMM: 29-204/298.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVC-FEKALWrmgplLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRP
.  |...|. .... . |....||  . ||.||.. ||.  |.|| .          .||||||||||.. .|||  |.. |.  |..||..|||||   
veklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagf.....ppdanylflGdyvdrGrqnlevivlllaykvkypnnffllrGnhecea

VQKMFHFEAECTQKFGATIgqqVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPENesQLAWELMWNDP
. ... |  ||....  .    .... .  |.|.|..|.. ..|.| |||. .    . || .....  | ...|.  .|| .|.| ||
inrvyGfyeeckrrykslr...lyaefqdvfnalpltaliggrilcmhGGlskk...lksldqlrelkrpfdskee..slaidllwadp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 583-771 3.5e-41 134.3 In-house 11-202 (302) alignment 
Range on Protein: 583-771
Range on HMM: 11-202/302.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCF-------EKALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRG
||.|...    | .|  |... .|  |.||.||.|.|||         |.|  ..    .   |.|||||||||.. .| |. .|. |.| | .. ..||
llllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrg

NHELRPVQKMFHFEAECTQKFGATIGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPENESqLAWELMWNDPL
||| . ..  . |. |  ...| . |...||  | .|  ||.||.| .||.| |||. .    . || .|.||  |||.  ..| || .|.. |||
nhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk...lesledikkikrplkevteds.laqdllfadpl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 583-771 5.1e-41 133.8 In-house 12-203 (302) alignment 
Range on Protein: 583-771
Range on HMM: 12-203/302.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCF-------EKALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRG
||.|...    | .|  |... .|  |.||.||.|.|||         |.|  ..    .   |.|||||||||.. .| |. .|. |.| | .. ..||
llllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptnyillrg

NHELRPVQKMFHFEAECTQKFGATIGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPENESqLAWELMWNDPL
||| . ..  . |. |  ...| . |...||  | .|  ||.||.| .||.| |||. .    . || .|.||  |||.  ..| || .|.. |||
nhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispk...lesledikkikrplkevteds.laqdllfadpl
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 583-770 4.2e-38 124.2 In-house 13-187 (281) alignment 
Range on Protein: 583-770
Range on HMM: 13-187/281.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCFEKALWRmgplLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPV
. .. ||.. ....|  |.....|. ..||||..|.||    . | |    ..   ..||||||||| ...||.  ||. ||  .|. ...|||||.  |
ienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgr....vpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheiasv

QKMFHFEAECTQkfgaTIGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPENesQLAWELMWNDP
.|.. |  ||       .|...|  .. ||. .||.| ..... | |||.      . .| |. ..| |.....    |  .|.| ||
nkiygfyvecvt....kyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPe...ltaldelrnrpkpirnldr..GlviDllwadp
subfamily_PPG1_pd Subfamily PPG1 583-770 2.6e-34 111.8 In-house 19-195 (300) alignment 
Range on Protein: 583-770
Range on HMM: 19-195/300.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVcfekALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPV
. .|.   . .| .|  .|....|  ..||.||.|.|..     ....|  .    .|||||||||| . || |. |   |.  | .  ..||||| | .
vkeltdklkellvkesnvieirspvtvvgdvhgqfydvl....eifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesrqi

QKMFHFEAECTQKFGATigQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEInKIPVPLKDPENESQLAwELMWNDP
 ... | .|| .|.|    ..||. .   || . .||..|..|.| |||.  |   | |. .| |.   ...  ||  || .|.| ||
tqvygfyteclrkyggn..srvwkylteifdylvlaaiideeiycvhgglsps...vlsidqi.kvldrfrevpnegala.dllwsdp
subfamily_PPZ_pd Subfamily PPZ 583-770 1.4e-33 109.7 In-house 30-204 (300) alignment 
Range on Protein: 583-770
Range on HMM: 30-204/300.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVC-FEKAlwrmGpLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRP
.| .| .|. .. ..| |..|. .  |.||.||.. ||.  | |.    | .   . .||||||||||.. .| |  |.  ||  |..||..|||||   
ilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkc....g.fppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

VQKMFHFEAECTQKFGAtigqQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPEneSQLAWELMWNDP
| ... |  || ..       ..|...   |...|.||.|  |||| |||.      . |. || ..  |   |.    |  .|.|.||
vtrvygfydeckrrcni....kiwktfvdtfntlplaaivagkifcvhgglspv...lnsmdeirhvvrptdvpd..fglindllwsdp
subfamily_PPP6C_pd Subfamily PPP6C 583-770 2.4e-33 108.5 In-house 20-195 (290) alignment 
Range on Protein: 583-770
Range on HMM: 20-195/290.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLvcfeKALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPV
| .||   . .| .|  .  ...|  . ||.||.|.||    . |.| |  .   |..||||.|||| . .| ...|.. |.  ||.  ..||||| | .
lkklcdlvldllleesnvqpvsspvtvcgdihgqfydl....eelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesrqi

QKMFHFEAECTQKFGATigqQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPEnESQLAwELMWNDP
 ... |  ||..|.| .   ..|  .   || ..|||..|....| |||.      |  | .|. |    . |. .  .. .|.| ||
tqvygfydeclnkygna...nawkyctkvfdlltiaaiideqvlcvhGglspd...vktldqirvieraqeiph.kgafc.dlvwsdp
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 583-770 3.7e-31 101.6 In-house 11-185 (280) alignment 
Range on Protein: 583-770
Range on HMM: 11-185/280.0
LLALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCFEKALWRMgpllTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPV
..|. |  . .. .|  |.. .||  ..||.| ...|.  .   . |.        ..||||||||| .|.||.  ||  ||   |. ...|||||   |
iiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrv....peeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsv

QKMFHFEAECTQKFGatIGqqVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKdPENeSQLAWELMWNDP
.|.. |  ||  |.|  .|  .|  ...||. ||..... ....| |||.      .  |  | .|| | . | .   |  .|.|.||
nkiygfyvecqykyg..vg..lwwdfqscfnrmpmsgliskrvlcmhgglspe...linldtirniprpce.pld.rgllidllwsdp
subfamily_PPP3C_pd Subfamily PPP3C 584-771 2.4e-45 148.2 In-house 47-221 (452) alignment 
Range on Protein: 584-771
Range on HMM: 47-221/452.0
LALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVcfekALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQ
| . .|| ..| .|. |....||  ..||.|| |.||.     |. .|   .  ..|||||||||| . .|.. ||.. ||  |...|..||||| | . 
lkiieeaakllkkektlleveaPitviGdihGqfydll....klfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecrhlt

KMFHFEAECTQKFGatigQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVpLKDPENESQLAwELMWNDPL
. | |. ||..|..    ..|..|.  .||..|.||..... .| |||.      . || .|.|.   .|.|..   |  .|.| |||
eyftfkeeckikys....eevydacmesfdslPlaallnqqflcvhGGlspe...ikslddikkldr.fkeppasGplc.dllWsdPl
subfamily_PPP4C_pd Subfamily PPP4C 584-770 7.6e-39 126.6 In-house 22-196 (288) alignment 
Range on Protein: 584-770
Range on HMM: 22-196/288.0
LALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLvcfeKALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQ
 |||..|. .| .|  . ....|  . ||.||.|.||    . |...|      ..|||||.|||| . || .  | . |.  ||.  .|||||| | . 
kalcakareilveesnvqrvdspvtvcgdihgqfydl....lelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrqit

KMFHFEAECTQKFGATigqQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPENeSQLAwELMWNDP
... |  || .|.|..   .||.     || ...||..|.|||| |||.  |   . .| ||  |    . |..  .|. .|.| ||
qvygfydeclrkygsa...nvwryctevfdylslaaiidgkifcvhgglsps...istldeirsidrkqevphe.gplc.dllwsdp
subfamily_PPP2C_pd Subfamily PPP2C 584-770 1.1e-37 122.8 In-house 23-197 (290) alignment 
Range on Protein: 584-770
Range on HMM: 23-197/290.0
LALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVcfekALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQ
 .|| .|. .|..|  . ....|  . ||.||.||||.     |...|       .|||||||||| . || ...| . |.  ...  ..||||| | . 
kelcekakeilskesnvqevkcpvtvcgdvhgqfhdll....elfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhesrqit

KMFHFEAECTQKFGATigqQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEGGVCSLAEINKIpvplKDPENESQLAwELMWNDP
... |  || .|.|..   .||. .   || .|..|.||..||| |||.  |   .  . .....    ..  .|  |. .|.| ||
qvygfydeclrkygna...nvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrl....qevphegplc.dllwsdp
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 584-771 2.5e-30 98.8 In-house 29-206 (297) alignment 
Range on Protein: 584-771
Range on HMM: 29-206/297.0
LALCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVcfekALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQ
| |   |  |. ..  ....|||  . ||.||.| ||.     |.. |     . .||||||||||   .| |  |.. |.  | ..|..|||||   |.
lklldlaldvfkaqksmvevnapikvcgdihgqfpdll....rlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnhecefvn

KMFHFEAECTQKFGATigqQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEGGVCSLAEINKIPVPLkdpENESQLAWELMWNDPL
|.. |  || ... .    ... |..  |. .|.. .. .||.| |||.        .|  ..||  .    | . .|  .|.| ||.
kvygfyeecqkryqsv...rmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierst...egkerlvadllwadpi
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 586-770 3e-35 114.7 In-house 14-185 (280) alignment 
Range on Protein: 586-770
Range on HMM: 14-185/280.0
LCREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCF-EKAlwrmgPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQK
. .. ...|. .  .....||  . |||||.. ||. . ...      .     .||||||||||.. .|||  |.. |.  |..|...|||||   ...
viekckkiltaqatmvevdapvavcgdlhgqytdllrlfarv.....sfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisinr

MFHFEAECTQKfgatIGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLkDPENESqLAWELMWNDP
 . |  |. ..      ..... ..  .| .|..|.|  .|.| |||. .    . || .....  |. |.|.|. || .|.| ||
kygfkdevkrr....yslalynefqelldslplvalvsgrilcmhgglsqk...lvslddlaelrrpf.dsedec.lamdllwadp
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 587-770 3.5e-31 101.5 In-house 29-202 (307) alignment 
Range on Protein: 587-770
Range on HMM: 29-202/307.0
CREAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVCFEKALWRmgPllTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQKMF
  ||| ... |  |. .. |  ..|||||.| ||. .   | |  |      ..| |||||||   .|.|  ||. ||  |..  ..|||||.  |.| .
iyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgr..p..petvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkky

HFEAECTQKFgATIGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPENesQLAWELMWNDP
 |  ||        |...|  .. ||. .||.|..  ||.| |||.  .   .  | |. . | |...|     .  ...| ||
gfyeecvtsi.pkcgeeiwalfqrcfnnlpisaliatkilcmhgglspa...ltcldelrnhpkpirnpfr..givndmlwadp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 589-770 3.1e-37 121.5 In-house 14-184 (284) alignment 
Range on Protein: 589-770
Range on HMM: 14-184/284.0
EAQRVLANEPRLIKLNAPTYILGDLHGNFHDLVC-FEKAlwrmgPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQKMFH
.|  .. ..| ||. |.|  | ||.||.| ||.  |.|       .   . .||||||||||.| .| |  ||. |.. |..|||.|||||   ..|.. 
hafsifnkqpmlievnspinicgdihgqfsdllrlfdkn.....gfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinkiyg

FEAECTQKFGAtigQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEGGVCSLAEINKipvPLKDPENEsQLAWELMWNDP
|  || ...       |. ...  |  ||..|.| ..|.| |||| .    |  |  |..   |. .|| .  || ...| ||
fyeecqrrynk...psvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikr...pfdnpepn.tlaidilwsdp
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 600-770 2.5e-35 115.4 In-house 2-165 (263) alignment 
Range on Protein: 600-770
Range on HMM: 2-165/263.0
LIKLNAPTYILGDLHGNFHDLVCFEKALwrmgPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQKMFHFEAECTQKFGA-
|..|.||  | || ||.. ||.   .|        |   .|||||||||| | .|||  ||| |.  | |....||||||. ..| . | ||  ..|   
llelqapinicgdthgqyndllrifnac....gaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqre

TIGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeggVCSLAEINKIPVPLKDPEnESQLAWELMWNDP
 . . |.. .|  |  ||..|.| ..|.| |||.      . || .|  ||.||.  .    || .|.| ||
evyesvynhfnqvfsymplcaivskrilcmhggisph...lkslddiraiplpletak.thplacdllwadp
Metallophos Calcineurin-like phosphoesterase 607-740 7.5e-25 81.4 Pfam-A 3-168 (200) alignment 
Range on Protein: 607-740
Range on HMM: 3-168/200.0
TYILGDLHGNFHDL-VcFEKALWRMGPLLTPCSFLFLGDYVDRGEHGVEVIAYL--FSQKILAPDKFFMIRGNHELRPVQKMFHFEAECTQ---------
  ..|||||...||   .. .| ...    |  .|||||.|||| .. |..|.|  ...|.|.|...|..||||| .|. . . |  |.           
ilvigDlHgglddled.lllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

---------------------KFGATIGQQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSEGGVC
                      ..   |  ..|... .|.|.|..| ||.||..|||..  |.| ..
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgd
PPP_4 608-770 1.7e-41 135.5 In-house 2-155 (197) alignment 
Range on Protein: 608-770
Range on HMM: 2-155/197.0
YILGDLHGNFHDLVC-FEKalwrMG-PLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQKMFHFEAECTQKfgatIGQQVW
.. ||.|| ..||.  . |    .|    .  |..|||||||||....||. .|.. |.  |......||||| . ..... |. |...|     |....
tvvGDiHGqlddlllkllk....ngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek....hgkeil

EAINCCFDAMPIAAVVDNKIFCTHGGVPNSEGGvcsLAEINKIPVPLKDPENESQLAWELMWNDP
.... .|| .|.||..|.|....|||....      |..|..|  . . | .|... . |.|.||
kklqdvfdllplaalidekvlvvhgglsdeles...ldkierierkiespleeekrkdlllwsdp
PPP_2 609-744 2.7e-42 137.7 In-house 3-131 (198) alignment 
Range on Protein: 609-744
Range on HMM: 3-131/198.0
ILGDLHGNFHDLVCFEKALwrmgPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQKMFHFEAECTQKFGatiGQQVWEAI
..|||||...||. . |         .  ..||||||||||....||. .|.. |.  |......||||| . |.|.. |. |...| |   |..|....
vcGDlHGqldDLlilfkng....lpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkg...gkkvykkl

NCCFDAMPIAAVVDNKIFCTHGGVPNSEGGVCSLAE
. .|...|.||..|.|....|||. ..   . .  .
qevfelLplaalidekvlvvHGGlseeiklldqikk
PPP_5_Dcr2 609-770 2.4e-41 134.9 In-house 3-156 (199) alignment 
Range on Protein: 609-770
Range on HMM: 3-156/199.0
ILGDLHGNFHDL-VCFEKALwrmGPLLTPCSFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQKMFHFEAECTQKFgatIGQQVWEA
..||||| ..|| . ..|     |   .  ...|||||||||....||. .|.. |.. |......||||| . ..... |. |. .|.    |......
vcGDlHGqlddlllilfkeg...gdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlsky...hgkkiyki

INCCFDAMPIAAVVDNKIFCTHGGVPNSEGGVCSLAEINKipvPLKDPENESQLAWELMWNDP
.. .|| .|.||..|.|....|||....   . .|..|..   . . ||.. . |. |.|.||
lsdvfdwlPlaalidekvlvvhgglspeiksiellekier...kieipeekgekadlllwsdp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 638-770 3e-32 105.1 In-house 102-225 (317) alignment 
Range on Protein: 638-770
Range on HMM: 102-225/317.0
SFLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQKMFHFEAECTQKFGAtigqQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSeg
 .|||||||||| . .||.  ||. |.| ||| |..||||| ||| . . |  |..... |    ...|| .  | ..|..|||..||.| |||....  
kylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysa....alyeafqlafnvlplcavvnkkilcmhGGisee..

gVCSLAEINKIPVPLKDPEneSQLAWELMWNDP
 . .| ...|.  ||. |.    .  .| | ||
.lldlkqldklkrpldipd..vGvladltwadp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 639-770 2.2e-21 69.4 In-house 122-244 (339) alignment 
Range on Protein: 639-770
Range on HMM: 122-244/339.0
FLFLGDYVDRGEHGVEVIAYLFSQKILAPDKFFMIRGNHELRPVQKMFHFEAECTQKFGAtigqQVWEAINCCFDAMPIAAVVDNKIFCTHGGVPNSegg
.||||||||||   .||.  | . |.  ||. ...||||| | |.  . |  |   .. |    |..|...  |. .|..||..| |.| |||. .    
ylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyryda....qlyecfqnmfnvfpfcavinntimcmhggiseh...

VCSLAEINKIPVPLKDPENesQLAWELMWNDP
. |. ..  .  ||. |.    .  .| | ||
ltsfnqfsvfkrpleipdv..gvltdltwadp