Gene PPP1C-2 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP152_AA protein Get Run
SpurP152_AA_5-306 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 6-304 2.5e-117 384.3 In-house 6-304 (309) alignment 
Range on Protein: 6-304
Range on HMM: 6-304/309.0
RLNVDNIIARLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETIC
.| ....| .||..  ... | ..|.| |.. |.|| .||..|.||||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...
pllllelilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevll

LLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL
||||.|..||.|.||||||||.. .|..|||.||..|.|...||. |.|....||..|.|..||.|.||||||||....|||...||...|. |||||||
lllalkllypdnvfllrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdll

WSDPDKETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDKNKK
||||. .. |...|.||....||  .| .|| |..||||.|.|..|..||..|....|.|.||||||||...|.||.. .||.|..||....|..   .
wsdplpiregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
subfamily_PPZ_pd Subfamily PPZ 8-301 5.4e-140 459.1 In-house 2-296 (300) alignment 
Range on Protein: 8-301
Range on HMM: 2-296/300.0
NVDNIIARLLEVR-GSRPGKNVQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICL
..|.|| .||.    ..  ||| | ..||  .| |.||.||.||.||||  ..|| ||.|||| ||||||   |||| |||||||||||||||||||| |
dideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletill

LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
||.||||||||||||||||||| . |.|||||||||| |||.|||| | || ||..||.  |||| |||||| |.||..||...||||||| ||. ||||
llcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllw

SDPDKETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDK
|||   .  | .|.||||. .    . ||| |  .||.|||| |||||||||  | |||.|||||||||||| ||.||| | |.|||..| | | 
sdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 8-301 6.1e-138 451.8 In-house 2-296 (298) alignment 
Range on Protein: 8-301
Range on HMM: 2-296/298.0
NVDNIIARLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLL
.||......|.|  |      ...|...  |. ....|| .|. |.|..||.|.|||||||| ||||||. .||||.|||||||||||||.|.||.|.||
evdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
||||.|||.|||||||||||..|||.||||.|||||| ...|...| | || ||.||.| ..|.| |||||. |.|..|.|.. ||.| ... |  ||||
laykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllw

SDPDKETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDK
.||.. . || || ||||..|| . | ..| | |.||..|||||| |||||||...|||.||||.|||.|||. |.|.||| |..||..|||..|
adpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekk
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 8-303 6.5e-129 422.4 In-house 2-298 (299) alignment 
Range on Protein: 8-303
Range on HMM: 2-298/299.0
NVDNIIARLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLL
.||.....||.|  |       . | |.. ||  ....|.||. |||.|||...|||||||| ||||.|.  ||||..|.||||||||||.| ||.|.||
dvdellskllnvgmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitll

LAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
|..||||||.||.||||||| .|||.||||.||..||.  .||  | |.|. .|.| .|  .|.| |||||| ||...|.| . || | |.  |  ||||
lcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllw

SDPDKETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDKNK
.|||.  ..|  | ||||. || ..|.. . . |.||..||||||.|||||||...|||.|||| |||.|||. |.| ||| |.|.|..|||..|. 
adpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpksl
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 9-299 5.9e-108 353.6 In-house 2-295 (297) alignment 
Range on Protein: 9-299
Range on HMM: 2-295/297.0
VDNIIARLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLL
||.||  .|            .||  .  |   . ..| .| ...|..||.|.|||||||. ||||||  ||.|| |||||||||||||. |.||| |||
vdsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlll

AYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSP---DLQSMEQIRRIMRPTDVpDQGLLCDL
|||.|.| |.|||||||||  .|..||||.||..||. .... .| | || ||.| .| .||.| ||||||   .  ... .|.| |.|.   ..|..||
aykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadl

LWSDPDKETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPS
||.||     |. ||.||    || . | |   . .|||.|||||||.||||||| |.|||.|||| |||.|||. |.||.|| | |||.||.|.
lwadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
0053225 Metallo-dependent phosphatases 11-298 5.1e-107 350.5 In-house 3-290 (293) alignment 
Range on Protein: 11-298
Range on HMM: 3-290/293.0
NIIARLLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAY
..| .||..  ..  ....|.| |.. |.|. .||....||||||.... ..|||||...|||.|.|. ||||| ...||||.|||| .|||...||||.
slilllldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllal

KIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDP
|..||.|..|||||||.. .| .|||.||..|.| . .||. ..|....||..|.|..||...|||||||| ...|||.|.||...|. |||.|||||||
kllypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdp

DkETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
| . .||. . ||....||  .| .|| |..||||.|.|||| |||... ...|||.||||||.|...|.||.. .|| |...|....|
d.lwsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfap
0045823 Metallo-dependent phosphatases 16-306 1.7e-119 392.5 In-house 29-331 (473) alignment 
Range on Protein: 16-306
Range on HMM: 29-331/473.0
LLEVRGSRPGKNVQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYP
 |..  ..  |. .|.| ... |. . .||. ..||||||.... ..||||||..|||||.|  ||||| ...||||.|||| .|||...||||.|||||
dldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikyp

ENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPdKETMG
.|.||||||||.. .| .|||.||. ..|...|.. | .....||..|.|..||...||||||||....|||.| || ..|| |||.|||||||  |..|
gnvfllrGNHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddg

--------WGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQ------LVTLFSAPNYCGEFDNAGAMMSVDETLmCSFQILKPSDK
        .| . ||....|| ..| .|| |..||||.|.|..|..|||.. ...      ..|.||||||||...| .|.. .||.| .||....||. 
dgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsph

NKKFP
 ...|
plilp
subfamily_PPP1C_pd Subfamily PPP1C 22-301 2e-163 535.3 In-house 2-281 (282) alignment 
Range on Protein: 22-301
Range on HMM: 2-281/282.0
SRPGKNVQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLL
|..||.|.|.||||. |. |.|||.|||| |||||||.||.|||||||.|||||||..|.|||.|||||||||||||||||||.||||||||||||.|||
skkgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfll

RGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDR
|||||.|||||||||||||||||.|||||||||.|||||..|..||||.|.||||||.|.|.||||.|.||..||..||||||||||||||..||.||||
rGnhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendr

GVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDK
||||||| ..|.||| |.|||||.||||||||||||||||||||.|||||||||||||||..||||.|..|||||||..|
GvsftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 27-302 5.6e-101 330.5 In-house 5-280 (281) alignment 
Range on Protein: 27-302
Range on HMM: 5-280/281.0
NVQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
.||.|. ||  .  . . || .. .| |...| .. ||.|.|. || ||||  | .||  ..|||||||||.||||.. ||...||.|... .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDRGVSFT
 ||.|.||||| ||. .| ..||  |  ||| |||.| |.... | ||||||.| .....| . .| . .|.||. ||||.|||.....| .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDKN
|| ..| .   . ...|| |||||| |||| .. |.|.|.||.||||  . ||.|.. |||||  |.. | |. ..
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpasep
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-302 1.7e-77 253.7 In-house 17-295 (307) alignment 
Range on Protein: 27-302
Range on HMM: 17-295/307.0
NVQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHE
..| |  |.  .  ... || |.  |.... |  . ||.|||. ||. .|   | |||. |.| |||||||  |||.| ||..||| ||||  |||||||
kiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhe

CASINRIYGFYDECKR---RYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDRGV
 | .|. ||||.||     .   ..|  |  ||| |||.|.|  ||.| |||||| |  ....|   .|   | .|.. |.||.|||   . |    || 
iarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgs

SFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDKN
 |||| ...     .  ..|| ||||.. |||  .. |.|.|.|||| ||  . |||... |||||      . |. .|
gftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpesen
subfamily_PPP2C_pd Subfamily PPP2C 28-301 1.2e-103 339.3 In-house 15-288 (290) alignment 
Range on Protein: 28-301
Range on HMM: 15-288/290.0
VQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEC
 ||.|.|.. || | .||. .. |. |...|. .|||.|||..||| ||  ||  |..||||||||||||  |.||..|| | |..|.|   .|||||| 
kqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhes

ASINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkETMGWGENDRGVSFT
  | ..||||||| |.| | ..|| ||| |..||.||..||.||| |||||| ......|| . |  .||..| |||||||||| .  |||  .||  .|
rqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagyt

FGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDK
|| .|  ||  . .| || ||||.| .||..  .|..||.|||||||    | .|.. .|..|  ||   .|. .
fgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpapr
subfamily_PPP3C_pd Subfamily PPP3C 28-290 2.8e-89 293.0 In-house 39-314 (452) alignment 
Range on Protein: 28-290
Range on HMM: 39-314/452.0
VQLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHEC
 .|.|...  .  .. ... ....|||.|||. ..||||||.||||.||| || | ...|||||||||||  |.|..  |.| ||.||...|||||||||
grleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhec

ASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKET------MGWGEN-D
  .   . | .||| .|. .........|..||..|..... .|.||||||...|...|... |  ..| .|.||||||||| ..         . .|  
rhlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsv

RGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAK------RQLVTLFSAPNYCGEFDNAGAMMSVDETLM
|| |. .. . |..|| | ||  | |||.. ..||. . |        |.||||||||.. ..| .|.. ...  |
rGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
subfamily_PPP6C_pd Subfamily PPP6C 29-298 2.1e-94 308.9 In-house 14-283 (290) alignment 
Range on Protein: 29-298
Range on HMM: 14-283/290.0
QLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 |.|.... || .  ...| . |.  ...|. .|||||||.|||. ||  ||  |...|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRY-NIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkETMGWGENDRGVSFTF
 | ..|||||||...| | . || .|. |. |.|.|||||...| |||||||.. ..||| | | ...| .| .|||.||||. .   |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpe.dvetwavsprgagylf

GIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
| .....|.   .|.|||||||.||.|.... . .|||..||||||    |  ........   .....| 
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfka
subfamily_PPG1_pd Subfamily PPG1 29-299 4.7e-87 285.0 In-house 13-296 (300) alignment 
Range on Protein: 29-299
Range on HMM: 13-296/300.0
QLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECA
 | |. .. |. | .|..... |. |...|. . ||.|||.||.| .|. ||  |..||||||||||||  |.||| ||.. |..||    |||||||  
llpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllrgnhesr

SINRIYGFYDECKRRY--NIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPD---------KETMG--
 | ..|||| || |.|  | ..|| .|. |. | ..|||||.|.| ||||||. .|..||. . |  .||..| |.|||||||.          .  |  
qitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhpdregqh

WGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPS
. . .||  ...| ..| ||| . |.. | ||||.. .||. .   .| |..||||||    |  ... . | .   |.. . .
fvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeea
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 29-298 2.8e-68 223.3 In-house 5-299 (302) alignment 
Range on Protein: 29-298
Range on HMM: 5-299/302.0
QLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPP-----------EANYLFLGDYVDRGKQSLETICLLLAYKIKYPEN
.... |.  |. .  | .  . .| |. .|. | ||||||. ||.|.. .                .  ..|||||||||..|.| |||..|.|. ||.|
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FFLLRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWSDPD-K
. |||||||. .||  ||| .| . |.      ..|. | ..|  .|..|.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||..||   
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

-------ETMGWGEN-DRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
       |.  . .|  ||.|..|    | ..  . .|.|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|..
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 29-297 5.4e-68 222.4 In-house 6-299 (302) alignment 
Range on Protein: 29-297
Range on HMM: 6-299/302.0
QLTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPP-----------EANYLFLGDYVDRGKQSLETICLLLAYKIKYPEN
.... |.  |. .  | .  . .| |. .|. | ||||||. ||.|.. .                .  ..|||||||||..|.| |||..|.|. ||.|
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

FFLLRGNHECASINRIYGFYDECKRRY----NIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRP-TDVPDQGLLCDLLWSDPD-K
. |||||||. .||  ||| .| . |.      ..|. | ..|  .|..|.. |||.| |||.|| |.|.|.|..| || ..| .. |  |||..||   
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

-------ETMGWGEN-DRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
       |.  . .|  ||.|..|    | ..  . .|.|| ||||..  |. |||...|.|.||||.|  | || ||.. ||     | ..|.
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
PPP_3 30-297 1.1e-113 371.8 In-house 2-270 (271) alignment 
Range on Protein: 30-297
Range on HMM: 2-270/271.0
LTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
|.| |.. |. | .||. ...||.|..||...|||||||..|||.||..||..|| .||||||||||||.|||...||||.|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDRGVSFTFG
||..|||..|.. .... |..|.....|..||..|.||||....||||||...|..||... |...||..|.|.|||.|...... |.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

IEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
 .....|| |..|.||.|||...|.|||.......||.|||||||....||||.....|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 30-298 8.1e-111 363.0 In-house 8-282 (284) alignment 
Range on Protein: 30-298
Range on HMM: 8-282/284.0
LTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFP------PEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRG
|.| |.  ||...||.|  ..  ||.|||.||.||||||. ||| |..  |.|       | .|||||||||||  |.| | ||.|||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDRGV
|||   .|. |||| |||.||  .|...|  .||..|..|....||.| |||.| || ...|. .. ||.|.|| |...|| |.||..| .|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
  .|| . | .|| |..|||. |||||| ||||||| |.|||.|||| |||..||..|...||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_PPP4C_pd Subfamily PPP4C 30-298 5.3e-105 343.8 In-house 16-284 (288) alignment 
Range on Protein: 30-298
Range on HMM: 16-284/288.0
LTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
..| |.. || |.|||.. . |. ....|  .|||||||.||||.||. ||  || |||||||.||||. |.||. ||||.|..||..  |.|||||. .
ikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesrq

INRIYGFYDECKRRY-NIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETmGWGENDRGVSFTFG
| ..||||||| |.| ....|.  |. |. |...||||.|||| ||||||.......|| | | ..||..| |||||||||.. . ||.   ||  . ||
itqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae.gwavsprgagylfg

IEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
 ..|..|  . |..|||||||.| .|| .  .....|..||||||    |  |.. .||.|   |.|.. 
sdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifea
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 30-302 2.4e-95 311.7 In-house 10-285 (287) alignment 
Range on Protein: 30-302
Range on HMM: 10-285/287.0
LTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... .|  .  | .||.   | |||.|||..|.||||||. ||||.|.  | .|. .||||||||||| .||| . ||...||.||..  |||||||.  
fsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkk

INRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP--DQGLLCDLLWSDPDKETMGWGEND-RGVSFT
||..|||..| ||... .|.|.| | |. ||. |.....|.| |||.||.|.|..... . .||     |.||  ||||.||.|.. .   |  |..|  
inklyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvv

FGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDKN
|| . | ..| | |.||| |||.|.|.||.|.....|||.|||| |.||  | ||.. |...|  ||  ||| | .
fGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedfe
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 30-299 7.9e-84 274.1 In-house 16-289 (290) alignment 
Range on Protein: 30-299
Range on HMM: 16-289/290.0
LTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECAS
... .|  .  | .||.   | |||.|||. | ||||||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  |||||||.  
fsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrk

INRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTD--VPDQGLLCDLLWSDPDK---ETMGWgENDRGVS
.||.|||..|  |. . .||| . | |. |.. | ...||.| |||.|....| | .. . .|      |.||  ||||.||..   .|.   .  |..|
vnrlygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtial.nkqrais

FTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPS
  || . . ..| |  |.|| |||.| |.|..|  ...|||.|||| |.|.  | ||.. | |.|  |. .||| 
vvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 30-82 2.8e-16 52.6 In-house 9-61 (317) alignment 
Range on Protein: 30-82
Range on HMM: 9-61/317.0
LTEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFP
..|.|.  ||...||.| ..|  ||||||..|.||||||. ||| |..  |.|
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwp
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 31-300 9.3e-121 395.2 In-house 7-276 (280) alignment 
Range on Protein: 31-300
Range on HMM: 7-276/280.0
TEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
 ||.| ..  | ..|.. |  ..|..||...|||.|||| ||||||.  .|||. ||||||||||||.| || |.||||||..||.||..||||||..||
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDRGVSFTFGIE
|| |||.||.||||. .|.. | . .. ||..|..  .|.| |||||..|.|........|| | .|. |  ||||.||.... ||.|| ||||  || .
nrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifgan

IVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSD
.| ..  | |.|||.| ||||.|||||||...|||.||||.|.|||||. |.. ||| |. ||..|||. 
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpal
PP2Ac_SM00156 31-298 4.3e-116 379.7 In-house 2-269 (271) alignment 
Range on Protein: 31-298
Range on HMM: 2-269/271.0
TEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.. |.. |. ...||. ...||.|..||. ..||||||..|||||.| .|.||| .|.|||||||||.||.|.|.||.|.||.|||...|||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDRGVSFTFGIE
|.||||..|.||.|. .... |...|..||..|..|.||.| ||||||.|.|...||.. |. . |..|||.|||||||.....|.  . ||.|..|| .
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

IVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKP
.|..|| |..|.||.|||.||..||||||...|||.|||||||.||.|..|...|...|..|.. ||.
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlke
PPP_1 31-285 2.1e-114 374.3 In-house 2-264 (264) alignment 
Range on Protein: 31-285
Range on HMM: 2-264/264.0
TEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
.|.|.. |. |..|.. ...||||.......|||||||..|||.||..||..|| |||||||||||||.|.|...||||.|.|||...||||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL-------WSDPDKETMGWGENDRG
...|||..|.. ..|. ...||.||.|..||..|.|||||...||||||.|....|||...| |.||..| |||||       .||........ ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
....|| ....||| |..|.||.|||.|.|.||||..||..||.|||.||. |..|.||....
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 31-299 2.4e-89 292.5 In-house 7-275 (280) alignment 
Range on Protein: 31-299
Range on HMM: 7-275/280.0
TEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASI
|  ||  .      ||. . || | |||.|. |||| || |. |||.  |  || . .||||||||| | .| . ||.. ||.| .  .|||||||  |.
tgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsv

NRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDRGVSFTFGIE
|.||||| ||. .| . ||  |  ||| .|....| ....| ||||||.|  .. || | || .  |.||| ||||||| ..  ||  . ||.|. ||  
nkiygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkg

IVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPS
.| .     ..||| ||||||.||||..| |.|.|.|| |||| .| || |.. ..  |  ||| | | 
vveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 31-82 1.4e-11 37.1 In-house 12-63 (339) alignment 
Range on Protein: 31-82
Range on HMM: 12-63/339.0
TEAEIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFP
  ||.  || ..||.  |.| .|.||||. . ||||||. ||| ...  |.|
caaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwp
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 34-301 3.1e-108 354.5 In-house 7-276 (284) alignment 
Range on Protein: 34-301
Range on HMM: 7-276/284.0
EIRGLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRI
..  | ... .||  || |.| ..|..||||||||. ||||||.  |||  ||||||||||||||. |||| ||.|||. .|. ||.|||||||. ||.|
dvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslinki

YGFYDECKRRYNI-KLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQG-LLCDLLWSDPDKETMGWGENDRGVSFTFGIEI
||||.||.||||   ....|   |  .|.||.. ..|.| |||.|  || . |.| | || | |.   |  |.||||| .   ||  | ||||. || . 
ygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsda

VSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDK
. |.| . ..||. ||||||.|||||||.|.|||.|||| |||.|||| |.| |.. |.||| .|.|  |
lrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkk
subfamily_PPPLV_pd Subfamily PPPLV 37-290 1.6e-56 184.7 In-house 4-280 (290) alignment 
Range on Protein: 37-290
Range on HMM: 4-280/290.0
GLCLKSREIFLSQPNLLELEAPLKICGDIHGQYYDLL----RLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINR
 || .. .|.... .||||..|  . ||.||.| ||      |.  |     |..||||||||||. |.| |. ||| |. ||  ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYNIKL---WKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQI---RRIMR--PTDVPDQGLLCDLLWSDPDKE-----------T
 . .. |.. ..  .|   |..|...|. ||..|.||.|.||.|.|.    ..  .|   . |.   . |.    |  |.|||||...            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

MGWGEND-RGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAgAMMSVDETLM
 |. .|| || .  |. . . .|| . .|. . |||.| | |...  | .|.|.||. .|||  ..| |.. ||.  .
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssnea.alilvdkkkl
subfamily_PPP5C_pd Subfamily PPP5C 39-288 6.8e-84 274.6 In-house 43-298 (322) alignment 
Range on Protein: 39-288
Range on HMM: 43-298/322.0
CLKSREIFLSQPNLLELEAP----LKICGDIHGQYYDLLRLFEYGGFPPEA-NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRI
 |...|.. ..| |.|.. .    | .|||||||.|||| .||  | | |   ||| ||.||||  |.|.| .||..|. ||..||| |||||  ..|..
lleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkl

YGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGL-SPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDkETMGWGENDRGVSFTFGIEIV
||| .|.| .|. |. . ||. || ||.. .|.||.. .|||| | |  .....|.| | .. |..|||..||||||. |..| ..  |||...|| .. 
yGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpq.eanGrspskrGvgvqfGpdvt

SKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV-DET
.||| . .|.|| |.|.| |.|||.  . .|.|.||||||| . .| ||.... .. 
kkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 52-301 2.1e-73 240.2 In-house 2-258 (263) alignment 
Range on Protein: 52-301
Range on HMM: 2-258/263.0
LLELEAPLKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNI-----
||||.||..|||| |||| ||||.|.  |   ...||||||||||| .||| | ||.. |.  | ...|||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPD-QGLLCDLLWSDPDKETMGWGEND-RGVSFTFGIEIVSKFLLKHDLDLI
 ... | . |. .|. ||. ..|.| |||.|| |.|...|| |  | .    . | |||||.||.|.. |.  |  | .|  || . |  .  . |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPSDK
 ||||||| || ||| |.|.|.|||  |  |. |  |.. |.. |  ||  ||| | 
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkpedf
Metallophos Calcineurin-like phosphoesterase 59-250 1e-45 149.5 Pfam-A 3-198 (200) alignment 
Range on Protein: 59-250
Range on HMM: 3-198/200.0
LKICGDIHGQYYDL----LRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLL--LAYKIKYPENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||...||    |.|.. .. ..  ..|||||.||||. |.||..||  |..|...| ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQIrrimrptdvpdqgllcdllwsdpdketmgwge
                        ... . .  . ..|..||. |..| ||...||.||....| ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGIEIVSKFLLKHDLDLICRAHQV
     |. ||.. ..|.|.|...||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 59-191 2.9e-38 124.6 In-house 66-201 (383) alignment 
Range on Protein: 59-191
Range on HMM: 66-201/383.0
LKICGDIHGQYYDLLRLFEYGGFPP-EANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY---NIKLWKTFTD
. .|||.||.  ||| ..   |.|  | .|.| ||.|||||.|.| ...|||. . ||....| |||||   .|  |||  | . .|   . |. ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPITAIIDEKIFCCHGGLSpDLQSMEQIRRIMR
 |  ||....|||||. .|||.| |  ..| . .| |
vfawlplatlidekilivhGGis.dktdlelldkier
subfamily_YNL217W_pd Subfamily YNL217W 59-179 1.7e-08 27.3 In-house 12-139 (235) alignment 
Range on Protein: 59-179
Range on HMM: 12-139/235.0
LKICGDIHGQYYDLLRLFE--YGGFPPEANYLFLGDYVDRGKQSLETICLLlaykikYPENFFLLRGNHECASINR------IYGFYDE--CKRRYNI--
| . ||.|| | .|..|..   ||  ...  ...|| ...| .|.|.. ..        ..   ..|||| . . .        |. .    ..   .  
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsfles

KLWKTFTDCFNCLPIT-AIIDEKIFCCHGGLSPD
|| |  ..    |. .  |  ....  |.||.| 
klskadmeyarelgfsldipsdellvvhaGlvpg
PPP_2 60-250 4.8e-82 267.4 In-house 2-197 (198) alignment 
Range on Protein: 60-250
Range on HMM: 2-197/198.0
KICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECK-RRYNIKLWKTFTDCFNC
..|||.|||..|||.||..|...|| .||||||||||||.|||...||||.|..||....|||||||....|..|||..|.. .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLL----WSDPDKETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQV
||..|.||||....|||||.......||... |....|..|.|.|||    .|||.... .. .. ||....|| ......| |..|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 60-250 9.8e-79 257.0 In-house 2-196 (197) alignment 
Range on Protein: 60-250
Range on HMM: 2-196/197.0
KICGDIHGQYYDL-LRLFEYGGFPP-EANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFN
 ..||||||..|| |.|...||.|. | .|.||||||||||.|||...||||.|..||....|||||||..|.|..|||..|...... ...|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQV
.||..|.||||....|||||..|.|...|.|| |....| ......|| ||||| ... |. .. ||....|| ....||| |..|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 60-251 1.8e-74 243.0 In-house 2-199 (199) alignment 
Range on Protein: 60-251
Range on HMM: 2-199/199.0
KICGDIHGQYYDL-LRLFEYGGFPP-EANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRR-YNIKLWKTFTDCF
 .|||.|||..|| |.||. ||.|. | .|.||||||||||.|||...||||.|..||....|||||||. ..|.||||..|.... .. |..|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPITAIIDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVP-DQGLLCDL-LWSDPDKETMG-WGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVV
..||..|.||||....||||||...|.|....| |....| ..|  .|| ||||| ... | . .. ||....|| ....||| |..|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 85-299 3.5e-97 318.4 In-house 101-315 (317) alignment 
Range on Protein: 85-299
Range on HMM: 101-315/317.0
ANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSME
 .|||||||||||  |.| . ||.|.|..||.. ||||||||  ..|. |||| |.|.||. .|...|   ||.||..|....||.| |||.| .| ...
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMS
|. .. ||.|.|| |.|.|| |.|||.|  |. |  || .. || . | .|| |.||||. |||||||||||||| |.|||.||||.|||..||..|..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDETLMCSFQILKPS
||. |..|...|.|.
vdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 86-304 7.4e-76 248.4 In-house 121-339 (339) alignment 
Range on Protein: 86-304
Range on HMM: 121-339/339.0
NYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPITAIIDEKIFCCHGGLSPDLQSMEQ
 |||||||||||  |.| . || | |. ||.  .|||||||  |.|  |||| | . ||. .|.. | . || .|. |.|.. |.| |||.|  | |..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPDQGLLCDLLWSDPDKETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSV
.  . || ..|| |.| || |.|||    |.    || || ||   .  || | ||... | |||||||||||  |.|||.||||||||. ||. |..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DETLMCSFQILKPSDKNKK
|. |  | ....|  ..||
dkklkisinvfrpesrdkk
subfamily_PPP7C_pd Subfamily PPP7C 201-297 6.6e-20 64.2 In-house 237-333 (383) alignment 
Range on Protein: 201-297
Range on HMM: 237-333/383.0
LCDLLWSDPDKETMGWGENDRGVSFTFGIEIVSKFLLKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILK
. |.||||| ...  . .  ||    || .. .|.| |..|.|. |.|.   .||||  .....|.||| ||  |  | || . . ..|.  .   .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyq