Gene PPP1C-3 in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP1C
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP153_AA protein Get Run
SpurP153_AA_18-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_PPZ_pd Subfamily PPZ 6-299 6.8e-139 455.5 In-house 1-296 (300) alignment 
Range on Protein: 6-299
Range on HMM: 1-296/300.0
LDIDSILTRLLEAR--GRPYKSVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVC
.||| |. .||.|    .  | | | ..|.  .|.|.||.||.|| ||||  ..|| ||.||||.||||||   |||| .||||||||||||||||||. 
vdideiiqklldagyaakrtknvclknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletil

LLLSYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLL
||| ||||||||||||||||||| . |.|||||||||| |||||||| | || ||.||||  |||| |||||| |..|..||...||||||. ||. |||
lllcykikypenffllrgnhecanvtrvygfydeckrrcnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindll

WSDPDKDVSGWGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
||||      | .|.||||. . .  . ||||.  .||.|||| |||||||||  | |||.|||||||||||| | .||| | |.|||..| | . 
wsdptdssnewednergvsycynkvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldplds
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 6-302 1.9e-128 420.9 In-house 1-299 (299) alignment 
Range on Protein: 6-302
Range on HMM: 1-299/299.0
LDIDSILTRLLEArGRPYKSV--NLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVC
||.| .|..||.  | . |..  .. | |.. ||  ....|.||. |||.|||...||||||||.||||.|.  |||||.|.||||||||||.| ||...
ldvdellskllnv.gmsekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelit

LLLSYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDL
||| .||||||.||.||||||| .|||.||||.||..||.  ..|  | |.|. .|.. ..  .|.| |||||| || ..|.| . || | |.  |  ||
lllcfkikyperffmlrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidl

LWSDPDKDVSGWGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAK
||.|||. | .|  | ||||. ||.|.| . ..| |.||..||||||.|||||||...|||.|||| |||.|||.  .| ||| |.|.|..|||..|..|
lwadpdqsvkdwlanvrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpkslk
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 8-300 1.5e-136 447.2 In-house 3-297 (298) alignment 
Range on Protein: 8-300
Range on HMM: 3-297/298.0
IDSILTRLLEARGRPYK-SVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLL
.|..|...|..  .  | .  ..|..|  |. ....|| .|. |.|..||.|.||||||||.||||||. .|||||.||||||||||||.|.||...|||
vdellievlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlll

SYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY-NIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWS
.||.|||.|||||||||||..|||.||||.|||||| .......| | || ||..|.. ..|.| |||||. |. ..|.|.. ||.| .|. |  ||||.
aykvkypnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwa

DPDKDVSGWGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKK
||.. |.|| || ||||..||.| | ..|.. |.||..|||||| |||||||...|||.||||.|||.|||. ..|.||| |..||..|||..|.
dpenavkgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpekke
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 9-297 3.3e-107 351.2 In-house 3-295 (297) alignment 
Range on Protein: 9-297
Range on HMM: 3-295/297.0
DSILTRLLEARGRP-YKSVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLS
|||.  .| |  .    |  .||  |  |   . ..| .|  ..|..||.|.|||||||. ||||||  ||.|| .||||||||||||. |.||. |||.
dsiiidvlsasthekllskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivllla

YKIKYPENFFLLRGNHECASINRIYGFYDECKRRYN-IKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSP---DLQCMEQIRRIMRPTDVPEtGLLCDLL
||.|.| |.|||||||||  .|..||||.||..||. .... .| | || ||.. .. .||.| ||||||   .  ... .|.| |.|.  | .|..|||
ykvkfpgnlfllrgnhecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkierstegke.rlvadll

WSDPDKDVSGWGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPS
|.||   .||. ||.||    || | | |     .|||.|||||||.||||||| |.|||.|||| |||.|||.  .||.|| | |||.||.|.
wadpisglsgfmenqrgagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilrpt
0049330 Metallo-dependent phosphatases 19-302 1.7e-114 375.0 In-house 21-304 (309) alignment 
Range on Protein: 19-302
Range on HMM: 21-304/309.0
RGRPYKSVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFL
.....| . |.| |.. |. | .||..|.|.||||.... ..||||||..|||||.|  ||||. ...||||.|||| .|||...|||..|..||.|.||
ielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalkllypdnvfl

LRGNHECASINRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGEND
||||||.. .|..|||.||..|.|....|. |.|....||.||....||.|.||||||||. ..|||...||...|..|||||||||||. ...|...|.
lrGNHElrllnglygfgdetlrkygaelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdplpiregfapnp

RGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAK
||....|| ..| .||....||||.|.|..|..||..|....|.|.||||||||...|.|... .||.|..||....|.. . .
rglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpllll
0053225 Metallo-dependent phosphatases 21-297 1.4e-105 345.8 In-house 15-291 (293) alignment 
Range on Protein: 21-297
Range on HMM: 15-291/293.0
RPYKSVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLR
. .. . |.| |.. |. . .||....|.||||.... ..|||||...|||.|.|. ||||.....||||.|||| .|||...|||..|..||.|..|||
lllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkllypdnvvllr

GNHECASINRIYGFYDECKRRY-NIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDkDVSGWGENDR
||||.. .| .|||.||..|.| . ..|. ..|....||.||....||...||||||||  ..|||.|.||...|..|||.|||||||| ..|||. . |
GNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpd.lwsgwlpsyr

GVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPS
|....|| ..| .||....||||.|.|||| |||... ...|||.||||||.|...|.|... .|| |...|....|.
glgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapv
subfamily_PPG1_pd Subfamily PPG1 21-294 2.1e-86 282.9 In-house 7-293 (300) alignment 
Range on Protein: 21-294
Range on HMM: 7-293/300.0
RPYKSVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLR
. .|.  | |. |. |. | .|.....  . |...|. . ||.|||. |.| .|. ||  ||.||||||||||||  |.||. ||.  |..||    |||
klqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklrypsritllr

GNHECASINRIYGFYDECKRRY--NIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPD---------K
||||   | ..|||| || |.|  | ..|| .|. |. | .|||.||.|.| ||||||. ....||. . |  .||. | |.|||||||.          
gnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennnptldhp

DVSG--WGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQIL
| .|  . . .||  ...|.|.| |||.  |.. | ||||.. .||. .   .| |..||||||    |   .. . | .   |.. 
dregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvy
subfamily_PPP1C_pd Subfamily PPP1C 22-299 2.3e-161 528.6 In-house 4-281 (282) alignment 
Range on Protein: 22-299
Range on HMM: 4-281/282.0
PYKSVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRG
. |.|.|.|||.. |. |.|||.||||||||||||.||.|||||||.|||||||..|.||.|||||||||||||||||||..|||.||||||||.|||||
kgkevklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrG

NHECASINRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGENDRGV
|||.|||||||||||||||||.||.||||||.|||||.||.|||||.|.||||||.|. .||||.|.||..|||.|||||||||||||.| ||.||||||
nhesasinriyGfydeckrrysiklWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGv

SFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
|||||.|.| |||...|||||.||||||||||||||||||||.||||||||||||||...||||.|..|||||||..|
sftfgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilkpakk
0045823 Metallo-dependent phosphatases 22-301 1.8e-117 385.8 In-house 37-328 (473) alignment 
Range on Protein: 22-301
Range on HMM: 37-328/473.0
PYKSVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRG
 .|   |.| ... |. . .||. ..| ||||.... ..||||||..|||||.|  ||||. ...||||.|||| .|||...|||..|||||.|.|||||
lkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkikypgnvfllrG

NHECASINRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPdKDVSG--------
|||.. .| .|||.||. ..|...... | .....||.||....||...||||||||. ..|||.| || ..|. |||.|||||||  ...|        
NHElrllnglygfgdetlekygedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdP.weddgdgllrlrf

WGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQ------LVTLFSAPNYCGEFDNAGGMMSVDETLmCSFQILKPSEKKA
.| . ||....|| |.| .||....||||.|.|..|..|||.. ...      ..|.||||||||...| .... .||.| .||....||. . 
fgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdpsphpl
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 23-295 4.1e-68 222.8 In-house 2-299 (302) alignment 
Range on Protein: 23-295
Range on HMM: 2-299/302.0
YKSVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYG------------GFPpDSNYLFLGDYVDRGKQSLETVCLLLSYKI
|.  .... |.  |. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|   . ..|||||||||..|.| .||....|.
yrkkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkv

KYPENFFLLRGNHECASINRIYGFYDECKRR----YNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRP-TDVPETGLLCDLLWS
 ||.|. |||||||. .||  ||| .| . |       .||. | ..|  .|.||.| |||.| |||.|| |...|.|..| || ..| |  |  |||..
lyptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfa

DPD-K-------DVSGWGE-NDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILK
||          .   . . . ||.|..| .  | .. .| .|.|| ||||..  |. |||...|.|.||||.|  | || | .. ||     | ..|.
dpldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlr
subfamily_PPP2C_pd Subfamily PPP2C 25-300 9.4e-103 336.4 In-house 14-289 (290) alignment 
Range on Protein: 25-300
Range on HMM: 14-289/290.0
SVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHE
. .|.|.||. || | .||. ..  . |...|. .|||.|||. ||| ||  ||  ||.||||||||||||  |.|||.|| . |..|.|   .||||||
ckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvrykeritilrgnhe

CASINRIYGFYDECKRRY-NIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDkDVSGWGENDRGVSF
   | ..||||||| |.| | ..|| ||| |..||..|.|||.||| |||||| ......|| . |  .||. | |||||||||| | .|||  .||  .
srqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpd.drggwgisprgagy

TFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKK
|||.||  || .. .| || ||||.| .||..  .|..||.|||||||    | .... .|..|  ||   .|. ..
tfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprr
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 25-298 1.5e-99 325.8 In-house 5-278 (281) alignment 
Range on Protein: 25-298
Range on HMM: 5-278/281.0
SVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHE
 |..|. |.  .  . . || ..  | |...| .. ||.|.|..|| ||||  | .|.  ..|||||||||.||||.. ||...||.|... .|||||||
kvqytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnhe

CASINRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGENDRGVSFT
 ||.|.||||| ||. .| ...|  |  ||| ||..| ..... | ||||||.| .....| . .| . .. ||. ||||.|||..| .| .  ||.|||
iasvnkiygfyvecvtkyGeelwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssft

FGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSE
||...| .   | ...|| |||||| |||| .. |.|.|.||.||||  . ||. .. |||||  |.. | |. 
fGknvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpas
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 25-293 2.9e-78 256.2 In-house 17-288 (307) alignment 
Range on Protein: 25-293
Range on HMM: 17-288/307.0
SVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHE
 .. |  |.  .  ... || |.  |.... |  . ||.|||. ||. .|   | ||.. |.| |||||||  |||.. ||..||| ||||  |||||||
kiqytkeefenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnhe

CASINRIYGFYDECKR---RYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGENDRGV
 | .|. ||||.||     .   .||  |  ||| ||..|..  ||.| |||||| | |....|   .|   |  |.. |.||.|||  |  |    || 
iarvnkkygfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgs

SFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQI
 |||| ...    .|  ..|| ||||.. |||  .. |.|.|.|||| ||  . ||| .. |||||      
gftfgtnviddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlva
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 25-296 2.4e-68 223.5 In-house 3-299 (302) alignment 
Range on Protein: 25-296
Range on HMM: 3-299/302.0
SVNLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYG------------GFPpDSNYLFLGDYVDRGKQSLETVCLLLSYKIKY
  .... |.  |. .  | .  .  | |. .|. | ||||||. ||.|.. .             .|   . ..|||||||||..|.| .||....|. |
kkeysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfs.sdkfvflGdyvdrGsksieciclvfalkvly

PENFFLLRGNHECASINRIYGFYDECKRR----YNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRP-TDVPETGLLCDLLWSDP
|.|. |||||||. .||  ||| .| . |       .||. | ..|  .|.||.| |||.| |||.|| |...|.|..| || ..| |  |  |||..||
ptnyillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadp

D-K-------DVSGWGE-NDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKP
          .   . . . ||.|..| .  | .. .| .|.|| ||||..  |. |||...|.|.||||.|  | || | .. ||     | ..|..
ldvqllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngklsisvlrn
subfamily_PPP4C_pd Subfamily PPP4C 27-296 5.9e-103 337.0 In-house 15-284 (288) alignment 
Range on Protein: 27-296
Range on HMM: 15-284/288.0
NLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECA
 ..| ||. || |.|||.. .  . ....|  .|||||||. |||.||. ||  |. |||||||.||||. |.||  |||..|..||..  |.|||||. 
likeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvrypdritlirgnhesr

SINRIYGFYDECKRRY-NIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDkDVSGWGENDRGVSFTF
.| ..||||||| |.| ....|.  |. |. |..|||.|.|||| ||||||... ...|| | | ..||. | |||||||||. |..||.   ||  . |
qitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpe.daegwavsprgagylf

GNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKP
|.|.| .| .. |..|||||||.| .|| .  .....|..||||||    |   .. .||.|   |.|.. 
gsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifea
subfamily_PPP6C_pd Subfamily PPP6C 27-295 1.5e-93 306.1 In-house 14-282 (290) alignment 
Range on Protein: 27-295
Range on HMM: 14-282/290.0
NLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECA
 |.|.... || .  ...| .  .  ...|. .|||||||. ||. ||  ||  ||..|.||||.||||  ||||. .||. |.|||..  |||||||. 
ylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypdritllrgnhesr

SINRIYGFYDECKRRY-NIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPdKDVSGWGENDRGVSFTF
 | ..|||||||...| | . || .|. |. |..|||.||...| |||||||.. ..||| | | ...|. | .|||.|||| .||. |   .||  . |
qitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdp.edvetwavsprgagylf

GNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILK
|. .. .|..  .|.|||||||.||.|.... . .|||..||||||    |   .......   .....|
gskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPP3C_pd Subfamily PPP3C 27-288 4e-88 289.2 In-house 40-314 (452) alignment 
Range on Protein: 27-288
Range on HMM: 40-314/452.0
NLTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECA
.|.|...  .  .. ... ... |||.|||. ..||||||. |||.||| || | ...|||||||||||  |.|.|  |.. ||.||...||||||||| 
rleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfllrGnhecr

SINRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWG------E-NDR
 .   . | .||| .|. .........|..||.||..... .|.||||||... ...|... |  ..|..|.||||||||| .| .         . . |
hlteyftfkeeckikyseevydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeekteekfvpnsvr

GVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAK------RQLVTLFSAPNYCGEFDNAGGMMSVDETLM
| |. ..   | .||.. ||  | |||.. ..||. . |        |.||||||||.. ..| . .. ...  |
GcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyennvm
PPP_3 28-295 1.1e-112 368.5 In-house 2-270 (271) alignment 
Range on Protein: 28-295
Range on HMM: 2-270/271.0
LTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECAS
|.| |.. |. | .||. ....|.|..||...|||||||..|||.||..||..|...||||||||||||.|||...|||..|||||....|||||||...
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

INRIYGFYDECK-RRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGENDRGVSFTFG
||..|||..|.. .... |..|.....|..||.||..|||....||||||... ..||... |...|||.|.|.|||.|..... .|.....||....||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

NDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILK
.|.. .||....|.||.|||...|.|||.......||.|||||||....||| .....|.|...|..|.
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 28-296 3.3e-110 361.0 In-house 8-282 (284) alignment 
Range on Protein: 28-296
Range on HMM: 8-282/284.0
LTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFP------PDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRG
|.| |.  ||...||.|  ... ||.|||.||.||||||. ||| |..  |.|       ...|||||||||||  |.| . ||..||...|.. |||||
lkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvfllrg

NHECASINRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGENDRGV
|||   .|. |||| |||.||  .....|  .||..|..|.|..||.| |||.| ||  ..|. .. ||.|.|. |...|| |.||...|.|. | .|| 
nhesrpvnmqygfyleckkrysealyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegykesprga

SFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKP
  .||.. | .||....|||. |||||| ||||||| |.|||.|||| |||..||.. ...||| |..||..|||
gkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlkp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 28-81 2.8e-17 55.8 In-house 9-62 (317) alignment 
Range on Protein: 28-81
Range on HMM: 9-62/317.0
LTEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPP
..|.|.  || ..||.| ..|. ||||||..|.||||||. ||| |..  |.| 
fkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnGwpl
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 29-299 1.2e-120 394.9 In-house 7-277 (280) alignment 
Range on Protein: 29-299
Range on HMM: 7-277/280.0
TEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASI
 ||.. ..  | ..|.. |  ..|..||...|||.|||||||||||.  .||||.||||||||||||.| || ..|||.||..||.||..||||||..||
keadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhevisi

NRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGENDRGVSFTFGND
|| |||.||.||||. .... | . .. ||..|.|  .|.| |||||..|. ........|| | ..  |  ||||.||...|.||.|| ||||  ||..
nrkygfkdevkrryslalynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsvifgan

IVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
.| .. .. |.|||.| ||||.|||||||...|||.||||.|.|||||. ... ||| |. ||..|||. .
vvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpalr
PP2Ac_SM00156 29-297 2.3e-115 377.3 In-house 2-270 (271) alignment 
Range on Protein: 29-297
Range on HMM: 2-270/271.0
TEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASI
.. ||. |. ...||. ... |.|..||. ..||||||..|||||.| .|.||...|.|||||||||.||.|...||...||.|||...|||||||. |.
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

NRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGENDRGVSFTFGND
|.||||..|.||.|. .|.. |...|..||.||.||.||.| ||||||.|. ...||.. |. . || |||.|||||||.....|.  . ||.|..||.|
nkiygfeeevkrkygkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFged

IVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPS
.| .||....|.||.|||.||..||||||...|||.|||||||.||.|.. ...|...|..|.. ||. 
avkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
PPP_1 29-282 1.3e-113 371.7 In-house 2-263 (264) alignment 
Range on Protein: 29-282
Range on HMM: 2-263/264.0
TEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASI
.|.|.. |. |..|.. ....|||.......|||||||..|||.||..||..|..|||||||||||||.|.|...|||..|.|||...||||||||....
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

NRIYGFYDECK-RRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLL-------WSDPDKDVSGWGENDRG
...|||..|.. ..|. .|.||.||.|..||.||..||||...||||||.|. ..|||...| |.|||.| |||||       .||.... ... ...||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

VSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMS
....||.|.. |||....|.||.|||.|.|.||||..||..||.|||.||. |..|.| ...
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvk
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 29-82 4.2e-13 42.1 In-house 12-65 (339) alignment 
Range on Protein: 29-82
Range on HMM: 12-65/339.0
TEAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPD
  ||.  || ..||.  |.||.|.||||. . ||||||. ||| ...  |.|  
caaelaelchrareliwsepiflkleapicvmgdihgqfddllamldmngwpls
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 30-299 4.2e-95 311.0 In-house 12-284 (287) alignment 
Range on Protein: 30-299
Range on HMM: 12-284/287.0
EAEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASIN
. ..  .  | .||.   | |||.|||..|.||||||. ||||.|.  | .|. .||||||||||| .||| . ||.|.||.||..  |||||||.  ||
dkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhevkkin

RIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPET--GLLCDLLWSDPDKDVSGWGEND-RGVSFTFG
..|||..| ||... ...|.| | |. ||. |.|...|.| |||.||.|. ..... . .||   .   ||  ||||.||.||  .   |  |..|  ||
klyGfkeelkrkrqerlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekdaktfelnkiraisvvfG

NDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEK
.  | ..|.. |.||| |||.|.|.||.|.....|||.|||| |.||  | | .. |...|  ||  ||| . 
kkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkpedf
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 31-302 1.3e-109 359.1 In-house 6-279 (284) alignment 
Range on Protein: 31-302
Range on HMM: 6-279/284.0
AEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINR
 .|  | ... .||  ||.|.| ..|..||||||||..||||||.  |||  .|||||||||||||. |||. ||..||. .|. ||.|||||||. ||.
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

IYGFYDECKRRYNI-KIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETG-LLCDLLWSDPDKDVSGWGENDRGVSFTFGND
|||||.||.||||   ....|   |  .|..|.| ..|.| |||.|  || . |.| | || | ||   |  |.||||| .   ||  | ||||. || |
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

IVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAK
 . |.|.| ..||. ||||||.|||||||.|.|||.|||| |||.||||  .| |.. |.||| .|.| .| |.
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrprkkiar
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 31-297 1.3e-82 270.1 In-house 19-289 (290) alignment 
Range on Protein: 31-297
Range on HMM: 19-289/290.0
AEVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINR
 ..  .  | .||.   | |||.|||. | ||||||  .||| |.  |.||. ..|||||||||| .|||   ||. |||.|...  |||||||.  .||
kdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevrkvnr

IYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTD--VPETGLLCDLLWSDPDKDVSG--WGENDRGVSFTFG
.|||..|  |. . ..|| . | |. |.. | |..||.| |||.|....  | .. . .|      . ||  ||||.||..| .     .  |..|  ||
lygfkeelarkrgsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqraisvvfg

NDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPS
.. . ..|..  |.|| |||.| |.|..|  ...|||.|||| |.|.  | | .. | |.|  |. .||| 
kkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkpr
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 32-297 1.4e-85 280.1 In-house 10-275 (280) alignment 
Range on Protein: 32-297
Range on HMM: 10-275/280.0
EVRGLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINRI
|.  .      ||. .  | | |||.|. |||| || |. |||.  |  |. . .||||||||| | .| . ||.  ||.| .  .|||||||  |.|.|
eiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhetpsvnki

YGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGENDRGVSFTFGNDIVG
|||| ||. .| . .|  |  ||| .|..... ....| ||||||.|  .. || | || .  . ||| ||||||| .   ||  . ||.|. ||. .| 
ygfyvecqykygvglwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisymfgkgvve

KFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPS
.  .  ..||| ||||||.||||..| |.|.|.|| |||| .| ||  .. ..  |  ||| | | 
qacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlipp
subfamily_PPPLV_pd Subfamily PPPLV 35-284 1.2e-56 185.2 In-house 4-276 (290) alignment 
Range on Protein: 35-284
Range on HMM: 4-276/290.0
GLCVKSREIFLSQPILLELEAPLKICGDIHGQYTDLL----RLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINR
 || .. .|....  ||||..|  . ||.||.| ||      |.  |     ...||||||||||. |.| .. ||. |. ||  ..|||||||  |.  
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

IYGFYDECKRRYNI---KIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQI---RRIMR--PTDVPETGLLCDLLWSDPDKDV-----------
 . .. |.. ..     ..|..|...|. ||.||..|.|.||.|.|.    ..  .|   . |.   . |.  . |  |.|||||..|            
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

SGWGEND-RGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGgMMSVD
 |. .|| || .  |..| . .||.| .|. . |||.| | |...  | .|.|.||. .|||  ..|  .. ||
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGssneaa.lilvd
subfamily_PPP5C_pd Subfamily PPP5C 37-286 4.4e-82 268.6 In-house 43-298 (322) alignment 
Range on Protein: 37-286
Range on HMM: 43-298/322.0
CVKSREIFLSQPILLELEAP----LKICGDIHGQYTDLLRLFEYGGFPPD-SNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINRI
 ....|.. ..| |.|.. .    | .|||||||. ||| .||  | | .   ||| ||.||||  |.|.. .||..|. ||..||| |||||  ..|..
lleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkllyPnhfflsrGnhesdnmnkl

YGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGL-SPDLQCMEQIRRIMRPTDVPETGLLCDLLWSDPDKdVSGWGENDRGVSFTFGNDIV
||| .|.| .|. |. . ||. || ||.| ...||.. .|||| | |   ....|.| | .. || |||..||||||..  .| ..  |||...|| |. 
yGfegevkakytekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe.anGrspskrGvgvqfGpdvt

GKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSV-DET
 |||.  .|.|| |.|.| |.|||.  . .|.|.||||||| . .| |..... .. 
kkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgdd
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 50-298 1.4e-74 244.1 In-house 2-257 (263) alignment 
Range on Protein: 50-298
Range on HMM: 2-257/263.0
LLELEAPLKICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNI-----
||||.||..|||| |||| ||||.|.  |    ..||||||||||| .||| . ||.| |.  | ...|||||||  .||. |||. | |.|..      
llelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevye

KIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPET-GLLCDLLWSDPDKDVSGWGEND-RGVSFTFGNDIVGKFLNRHDLDLI
 ... | . |. .|..||| ..|.| |||.|| |. ...|| |  | .  .|  | |||||.||.||  |.  |  | .|  ||.  |  . .| |.|||
svynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpekdakgfepnkiraisnvfgkkevddlckrldidli

CRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSE
 ||||||| || ||| |.|.|.|||  |  |. |   .. |.. |  ||  ||| .
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkped
Metallophos Calcineurin-like phosphoesterase 57-248 2.1e-44 145.2 Pfam-A 3-198 (200) alignment 
Range on Protein: 57-248
Range on HMM: 3-198/200.0
LKICGDIHGQYTDL----LRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLL--LSYKIKYPENFFLLRGNHECASINRIYGFYDECK-----------
  ..||.||.. ||    |.|.. .. ..  ..|||||.||||. |.|| .||  |..|...| ..||||||||. ..|  |||..|.            
ilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglangee

-----------------------RRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQIrrimrptdvpetgllcdllwsdpdkdvsgwge
                        ... ...  . ..|..|| .|.|| ||...||.||....  ..|                                
eyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi................................

ndrgVSFTFGNDIVGKFLNRHDLDLICRAHQV
     |. ||.| . |.|.....||..|.|. 
....gselfgpdalekllekygvdlvlrGHtH
subfamily_PPP7C_pd Subfamily PPP7C 57-186 8.5e-39 126.3 In-house 66-201 (383) alignment 
Range on Protein: 57-186
Range on HMM: 66-201/383.0
LKICGDIHGQYTDLLRLFEYGGFPPD-SNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINRIYGFYDECKRRY---NIKIWKTFTD
. .|||.||.  ||| ..   |.|    .|.| ||.|||||.|.| ...||.. . ||....| |||||   .|  |||  | . .|   . || ... |
vtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillillalllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlled

CFNCLPVAAIVDEKIFCCHGGLSP--DLQCMEQIRR
 |  ||.|...||||. .|||.|   ||. ...| |
vfawlplatlidekilivhGGisdktdlelldkier
PPP_2 58-248 3.3e-82 268.0 In-house 2-197 (198) alignment 
Range on Protein: 58-248
Range on HMM: 2-197/198.0
KICGDIHGQYTDLLRLFEYGGFPPDSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINRIYGFYDECK-RRYNIKIWKTFTDCFNC
..|||.|||..|||.||..|...|...||||||||||||.|||...|||..|..||....|||||||....|..|||..|.. .... |..|.....|..
tvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfel

LPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVPETGLLCDLL----WSDPDKDVSGWGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQV
||.||..|||....|||||.... ..||... |....||.|.|.|||    .|||... ... .. ||....||.|.. ..|....|.||.|||.|
LplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 58-248 5e-79 257.9 In-house 2-196 (197) alignment 
Range on Protein: 58-248
Range on HMM: 2-196/197.0
KICGDIHGQYTDL-LRLFEYGGFPP-DSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKIWKTFTDCFN
 ..||||||..|| |.|...||.|. ...|.||||||||||.|||...|||..|..||....|||||||..|.|..|||..|...... .|.|...|.|.
tvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlekhgkeilkklqdvfd

CLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVP-ETGLLCDL-LWSDPDKDVSGWGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQV
.||.||..|||....|||||..|. ...|.|| |....| | ....|| ||||| .. .|. .. ||....||.|.. |||....|.||.|.|..
llplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 58-249 2.2e-75 246.0 In-house 2-199 (199) alignment 
Range on Protein: 58-249
Range on HMM: 2-199/199.0
KICGDIHGQYTDL-LRLFEYGGFPP-DSNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINRIYGFYDECKRR-YNIKIWKTFTDCF
 .|||.|||. || |.||. ||.|. . .|.||||||||||.|||...|||..|..||....|||||||. ..|.||||..|.... .. ||.|...|.|
tvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdvf

NCLPVAAIVDEKIFCCHGGLSPDLQCMEQIRRIMRPTDVP-ETGLLCDL-LWSDPDKDVSG-WGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVV
..||.||..|||....||||||... .|....| |....| |.|  .|| ||||| ....| . .. ||....||.|.. |||....|.||.|.|...
dwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshelk
subfamily_YNL217W_pd Subfamily YNL217W 58-177 2.3e-08 26.8 In-house 13-139 (235) alignment 
Range on Protein: 58-177
Range on HMM: 13-139/235.0
KICGDIHGQYTDLLRLFE--YGGFPPDSNYLFLGDYVDRGKQSLETVCLLlsykikYPENFFLLRGNHECASIN------RIYGFYDE--CKRRYNI--K
 . ||.|| | .|..|..   ||  ..   ...|| ...| .|.|.| ..        ..   ..|||| . .       .  |. .    ..   .  |
lvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvllaykwvkkpkgaeplefsskfsflesk

IWKTFTDCFNCLPVA-AIVDEKIFCCHGGLSPD
. |  ..    |. .  |  ....  |.||.| 
lskadmeyarelgfsldipsdellvvhaGlvpg
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 83-297 2.7e-95 312.2 In-house 101-315 (317) alignment 
Range on Protein: 83-297
Range on HMM: 101-315/317.0
SNYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCME
..|||||||||||  |.| | ||...|..||.. ||||||||  ..|. |||| |.|.||. .....|   ||.||..|.|..||.| |||.| .|  ..
kkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkrysaalyeafqlafnvlplcavvnkkilcmhGGiseelldlk

QIRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMS
|. .. ||.|.|. |.|.|| |.|||..|.|. |  || .. ||.. | .||...||||. |||||||||||||| |.|||.||||.|||..||.. ..|
qldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaavls

VDETLMCSFQILKPS
||. |..|...|.|.
vdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 84-300 2.9e-72 236.6 In-house 121-337 (339) alignment 
Range on Protein: 84-300
Range on HMM: 121-337/339.0
NYLFLGDYVDRGKQSLETVCLLLSYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKIWKTFTDCFNCLPVAAIVDEKIFCCHGGLSPDLQCMEQ
 |||||||||||  |.| | || . |. ||.  .|||||||  |.|  |||| | . ||. .... | . || .|..|.... |.| |||.|  |  ..|
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyrydaqlyecfqnmfnvfpfcavinntimcmhggisehltsfnq

IRRIMRPTDVPETGLLCDLLWSDPDKDVSGWGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSV
.  . || ..|. |.| || |.|||    |.    || || ||   .  ||.. ||... | |||||||||||  |.|||.||||||||. ||.  ..|.
fsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfsi

DETLMCSFQILKPSEKK
|. |  | ....|  . 
dkklkisinvfrpesrd
subfamily_PPP7C_pd Subfamily PPP7C 199-293 5e-20 64.5 In-house 237-331 (383) alignment 
Range on Protein: 199-293
Range on HMM: 237-331/383.0
LCDLLWSDPDKDVSGWGENDRGVSFTFGNDIVGKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQI
. |.||||| ..   . .  ||    || |.  |.|....|.|. |.|.   .||||  .....|.||| ||  |  | |  . . ..|.  .  
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivq