Gene PPP2C in Strongylocentrotus purpuratus

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold PPPL
Superfamily PPPL
Family PPP
Subfamily PPP2C
Protein sequence
ID Type Fasta BLAST phosphatome Note
SpurP155_AA protein Get Run
SpurP155_AA_3-294 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049330 Metallo-dependent phosphatases 4-294 1.8e-113 371.6 In-house 12-302 (309) alignment 
Range on Protein: 4-294
Range on HMM: 12-302/309.0
VSTKDLDIEIEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLK
. ...||. ||.|  .|.|.|.....|...||||| .|.|..|.. ...|.||.|||..||..|... |  |.....|.||.||||..|.|...|| .||
lilslldllielllklkllseeellllllkakeilksepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvdrGpdslevlllllalk

VRYRERITILRGNHESRQITQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD
..|......||||||.|.....|||.||.||||| |..|..|.|....|||.|...|.|.| ||||||.. .||.||.|.| .|.|..|..||||||||.
llypdnvfllrGNHElrllnglygfgdetlrkyg.aelweefldwlrslplaaviggkilcvHgGlspdlllldqirelerpleipldgllcdllwsdpl

-DRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPRR
 .| |.. .|||.|..|| .. | | . |||.|| |.|..|..|| ...|....|.|||||||.|.||..|..|.|. |..|||.|.|.|. 
piregfapnprglgvvfghtaverflkkngldliirghgavfgGyltffdgklitvfsapnycgrlgnlgavleidedlvisfllfepvpll
0053225 Metallo-dependent phosphatases 5-292 3.6e-109 357.5 In-house 5-292 (293) alignment 
Range on Protein: 5-292
Range on HMM: 5-292/293.0
STKDLDIEIEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKV
 . .||. ||.|  .|.| |.....|...||||| ||.|..|.. ...|.||.||...||..|... |  |.....|.||.||||..|.|...|| .||.
illlldllielllllkllseeelllllleakeilkkepnllelsmriyviGDiHGnlddLlallekigfppedrlvflGDlvdrGpdslevlelllalkl

RYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD
.|......||||||.......|||.||.|||||.|..|....|....|||.||..|.|.. ||||||....||.|| ..| ...|.||...||||||||.
lypdnvvllrGNHElmllnglygfgdetlrkygaaelwdelldwlrslplaaliggkilfvHgGlspdlslldqireinrplriplegllldllwsdpdl

RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAP
. ||..|.||.|..|| .. . | . |||.|| |.||.|..|| ...|...||.||||||..|.||..|...||. |...| .|.| .
wsgwlpsyrglgvvfghtavlrflkkngldliirghqvvpdgylpwfdgklvtvfsapnylgrlgnlgavlaldeglvwgfklfapvl
subfamily_PPP2C_pd Subfamily PPP2C 6-295 1.8e-192 630.8 In-house 1-290 (290) alignment 
Range on Protein: 6-295
Range on HMM: 1-290/290.0
TKDLDIEIEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVR
.||||  ||.|..||||.|..||.|||.|||||.|||||||||||||||||||||||||.|||.|||.||.|||||.||||||||||||||||||.||||
ikdldklieklkeckqleesevkelcekakeilskesnvqevkcpvtvcgdvhgqfhdllelfkiggkspdtnylflgdyvdrgyysvetvtllvalkvr

YRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR
|.||||||||||||||||||||||||||||||||||||||||||||||||||||.|||||||||||||||||.||||||.||||||||.|||||||||||
ykeritilrgnhesrqitqvygfydeclrkygnanvwkyftdlfdylpltalvdeqifclhgglspsidtldkiraldrlqevphegplcdllwsdpddr

GGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPRRG
|||||||||||||||.||||.||..||||||.||||||||||||.||||||||||||||||||||||||.||||.|||||||||||||||
ggwgisprgagytfgkdisekfnktngltliarahqlvmegynwshdrnvvtifsapnycyrcgnqaailelddklkysflqfdpaprrg
0045823 Metallo-dependent phosphatases 6-293 2e-119 392.3 In-house 27-326 (473) alignment 
Range on Protein: 6-293
Range on HMM: 27-326/473.0
TKDLDIEIEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVR
  |||. ||.|  ...| |.... |...||||| ||.|..|.. ...|.||.|||..||..|... |. |.....|.||.||||..|.|.. || .||..
lldldlliehlkkegllpeedllklldeakeilkkepnllelsmrivviGDiHGqlddLlrllekigfppedrlvflGDlvDrGpdslevlelllalkik

YRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR
| .....||||||.|.....|||.||.|.|| .......| .....|||.|...|.|.. ||||||....|| ||...| .|.|..|...|||||||.. 
ypgnvfllrGNHElrllnglygfgdetleky.gedlyeeflewlrslPlaaviggkilfvHGGlspdlplldqireierpleipddgllldllwsdPwed

GG--------WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRN------VVTIFSAPNYCYRCGNQAAIMELDDALkYSFLQFDPA
 |        .| |||||||.||.|. | | . |||.|| |.|. |.|||....|..      ..|.|||||||.|.|| ||....|. | .|| ||||.
dgdgllrlrffgnsprgagylFgpdaveeflkkngldlivrGHthvpeGyellfdgkvigiDtgiTvfSApnYcgrggnlaAvlvidedl.isfiqfdps

PR
| 
ph
subfamily_PPP7C_pd Subfamily PPP7C 6-185 3.4e-38 124.3 In-house 17-202 (383) alignment 
Range on Protein: 6-185
Range on HMM: 17-202/383.0
TKDLDIEIEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKC----PVTVCGDVHGQFHDLMELF-RIGGRSPNTNYLFMGDYVDRGYYSVETVTLLV
.....  ||...  |.|  . | ..   ||..| .  |...|.      ||||||.||.. ||. .. . |  |.. .|.| ||.||||  ||| . .|.
kdeveklieafkekkllhakyvllilreakkvlkqlpnisrvstaiskevtvcGdlhGklddlllilyknGlpseenpyvfnGdfvdrGkesveillill

CLKVRYRERITILRGNHESRQITQVYGFYDECLRKY--GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDtLDHIRALDRI
.| . | . . . |||||   .   |||  |   ||   .... . . |.| .|||..|.| .|. .|||.| . | |. .  ..| 
alllvypkevylnrGnhedhilnlryGfikeveskykvhgkkilrlledvfawlplatlidekilivhGGisdktd.lelldkiers
subfamily_PPP4C_pd Subfamily PPP4C 7-292 4.9e-151 494.8 In-house 1-286 (288) alignment 
Range on Protein: 7-292
Range on HMM: 1-286/288.0
KDLDIEIEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRY
.||| .||.|..|. ..|..||.||. |.||| .|||||.|..|||||||.||||.||.|||..||  |.|||||.||.||||.|||||  ||..|||||
sdldrqieklrrcelikeeevkalcakareilveesnvqrvdspvtvcgdihgqfydllelfkvggdvpetnylflgdfvdrgfysvetfllllalkvry

RERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG
 .|||..||||||||||||||||||||||||.||||.| |..||||.|.|..||.|||.||||||||.|||.||..|| ||||||||.||||||||.|  
pdritlirgnhesrqitqvygfydeclrkygsanvwryctevfdylslaaiidgkifcvhgglspsistldeirsidrkqevphegplcdllwsdpedae

GWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAP
||..||||||| ||.|..|.||..|...||.||||||||||..  ...|.|..||||||||||| |||.|||..|.. |  |. |.
gwavsprgagylfgsdvveqfneandielicrahqlvmegyklhfnekvltvwsapnycyrcgnvaaileldeeldkdfkifeaaa
subfamily_Cele-PPP-Subfam4_pd Subfamily Cele-PPP-Subfam4 7-292 1.1e-100 329.5 In-house 9-295 (298) alignment 
Range on Protein: 7-292
Range on HMM: 9-295/298.0
KDLDIEIEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRY
. | . ... . .|...|..|..|.|.||.|..| . . ||. |..||||.|||. ||. ||  .|  |..||||.||||||| ...|...||.. ||.|
evlsvslsekkltkvikeedveklielakkifkkqkslvevdapikvcGdihGqysdllrlfdkagfppdanylflGdyvdrGrqnlevivlllaykvky

RERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD-R
 ... .||||||  .| .|||||.|| |.| . .... | |.|. ||||||. |.|.|.|||||. . .||..|.| | .. ..|    ||||.||..  
pnnffllrGnheceainrvyGfyeeckrrykslrlyaefqdvfnalpltaliggrilcmhGGlskklksldqlrelkrpfdskeeslaidllwadpenav

GGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAP
 ||  . ||....||.|  . . ..  . |. ||||.| .||..  ....|||||||.|| .  | ||.|..|. |. ||  . |. 
kgwaensrGvsvvfGedvvkdllekldidlvvrahqvvqdGyeffaekklvtifsaphycgqfdnsaavmkvdeklvvsfevlkpek
subfamily_PPP6C_pd Subfamily PPP6C 9-289 1.5e-138 453.8 In-house 2-282 (290) alignment 
Range on Protein: 9-289
Range on HMM: 2-282/290.0
LDIEIEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRE
||  ||. ..|| | ||..|.||.. ...| .||||| |..|||||||.||||.||.|||| ||. |.|.|.|.||.|||||||.||.|.|..||..| .
ldkwielakkckylpendlkklcdlvldllleesnvqpvsspvtvcgdihgqfydleelfrtggqvpdtsyvflgdfvdrgyysletftrlltlkakypd

RITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGGW
|||.|||||||||||||||||||||.||||||.|||.|..|| |...|..|.|..|.|||||| . |||.|| ..| ||.||.|..|||.||||.|   |
ritllrgnhesrqitqvygfydeclnkygnanawkyctkvfdlltiaaiideqvlcvhGglspdvktldqirvieraqeiphkgafcdlvwsdpedvetw

GISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFD
 .||||||| ||. ... |.| | | ||.||||||.||...  | ..||..||||||||||| |.|..|.|| . ..  |.
avsprgagylfgskvtkefvhinnlklicrahqlveeglkymfdeklvtvwsapnycyrcgnvasilaledaeereaklfk
subfamily_PPG1_pd Subfamily PPG1 9-293 6.2e-130 425.8 In-house 1-298 (300) alignment 
Range on Protein: 9-293
Range on HMM: 1-298/300.0
LDIEIEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRE
||  .|.|. .. | |  ||.|..  ||.| |||||.|...|||| |||||||.|..|.|.|||. |.|||||.|||||||.|||||..||..||.||  
ldecleklqkaellpevtvkeltdklkellvkesnvieirspvtvvgdvhgqfydvleifkiggqvpdtnylflgdyvdrglysvetisllivlklryps

RITILRGNHESRQITQVYGFYDECLRKY-GNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD----
|||.||||||||||||||||| |||||| ||..||||.|..|||| |.|..| .|.|.|||||||. ..| |. |||..|||.|| ..|||||||.    
ritllrgnhesrqitqvygfyteclrkyggnsrvwkylteifdylvlaaiideeiycvhgglspsvlsidqikvldrfrevpnegaladllwsdpeennn

------DRGG--WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPR
      || |  . .|.|||||..|.|. | | . | .  | |||||..|||.   |  . |..|||||||||||.|.|.|| . ... |  .. ||.
ptldhpdregqhfvvsqrgagysygkdvvekflrnndmnriirahqlcnegyqilfdnklstvwsapnycyrcgnkasilelyekderyfnvyeeape
subfamily_PPP5C_pd Subfamily PPP5C 11-290 1.5e-84 276.8 In-house 23-308 (322) alignment 
Range on Protein: 11-290
Range on HMM: 23-308/322.0
IEIEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCP----VTVCGDVHGQFHDLMELFRIGGR-SPNTNYLFMGDYVDRGYYSVETVTLLVCLKVR
  .|.... |.|..  . ..  .|||.| |.. . |.. .    .|||||.||||.||...|.. |. |..  ||| ||.|||| .|||.. .|...|. 
ellelfkkqkklhkkyalkilleakellkklpslveitieetkkltvcGdihgqfydllnifelnGlpseenpylfnGdfvdrGsfsveviltllgfkll

YRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSI-DTLDHIRALDRIQEVPHEGPMCDLLWSDPDD
| ... . |||||| .. ..||| .|.  || ...| . ||..|..|||. ... ... .||||  .   |||..| .|| .. |.|| ...||||||..
yPnhfflsrGnhesdnmnklyGfegevkaky.tekvadlftevfnwlPlahvinekvlvvhGGlfsedgvtlddlrkidrnaqppeegllvellwsdpqe

RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL-DDALKYSFLQFDP
. | . | || | .|| |... | ..|.|.|| |.|.. .|||.  || ...|.||||||| . ||..|...| .| ||  | .|. 
anGrspskrGvgvqfGpdvtkkflkennleliirshevkeeGyevehdGklitvfsapnycdqmgnkgafitlrgddlklkfktfea
subfamily_Cele-PPP-4B_pd Subfamily Cele-PPP-4B 13-294 2.5e-92 302.3 In-house 15-297 (299) alignment 
Range on Protein: 13-294
Range on HMM: 15-297/299.0
IEQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITI
  . .  | ..|.....||..||....... . ||. |. ||||.|||. ||. .| . |  |..|.||.|||||||   .|..|||.| |..| ||. .
msekrltksvkeqelqtlcavaksvfasqaslleveapiivcgdihgqysdllrifdkagfppdvnflflgdyvdrgrqnlelitlllcfkikyperffm

LRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGIS
||||||   | .|||||.|| ..|  . .|  | | |...||| |. ..|.|.|||||| ..||| .| | | |. |      ||||.|||.   .|   
lrgnhecpainrvygfyeecnkrykstrlwsifqdafaampltgligsrilcmhgglspklqtldqlrdltrpqdppnpslgidllwadpdqsvkdwlan

PRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPRR
 ||  | ||||. .   .  .. |..||||.| .||..  ....||||||| || .  | ||||..|. |  .|  . |.|..
vrgvsyvfgqdvvadvisrldidlvarahqvvqdgyeffaskklvtifsaphycgqfdnsaaimkvdenlvctfvvlkptpks
subfamily_PPP3C_pd Subfamily PPP3C 14-279 1.9e-88 290.2 In-house 33-311 (452) alignment 
Range on Protein: 14-279
Range on HMM: 33-311/452.0
EQLNDCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITIL
| .    .|.|... .. |.| ..| ||... ||. |.||.||.||||.||..|| .||   .|.|||.||||||||.|.|.|  | .||. | ... .|
ehflkegrleeeaalkiieeaakllkkektlleveaPitviGdihGqfydllklfevgGdPastkylflGdyvdrGyfsiecvlylyalkiaypstlfll

RGNHESRQITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRGGWGI---
|||||.| .|. . | .||  ||.. .|.. ... || |||.||...| .|.|||||| | .|| |. ||| .|.|. ||.|||||||| .. |      
rGnhecrhlteyftfkeeckikyse.evydacmesfdslPlaallnqqflcvhGGlspeikslddikkldrfkeppasGplcdllWsdPledygeektee

-----SPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHD------RNVVTIFSAPNYCYRCGNQAAIMELDD
     |.||  | ..   . .| ..| |  | |||.   .||.  ..        ..|.||||||.    |.||......
kfvpnsvrGcsyfysykavceflqkndllsiiraheaqdaGyrmyrkseatgfPslitlfsapnyldvynnkaavlkyen
subfamily_Cele-PPP-4D_pd Subfamily Cele-PPP-4D 18-289 1.8e-77 253.5 In-house 19-293 (297) alignment 
Range on Protein: 18-289
Range on HMM: 19-293/297.0
DCKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNH
 .| . |..| .| ..| ... .. .. ||..|. ||||.|||| ||. ||. ||  | .||||.||||||| .|.||. ||.. ||..   . .|||||
lskviteervlklldlaldvfkaqksmvevnapikvcgdihgqfpdllrlfhrggwpptanylflgdyvdrgrfsietivlllaykvkfpgnlfllrgnh

ESRQITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSP---SIDTLDHIRALDRIQEVpHEGPMCDLLWSDPD-DRGGWGISPR
|   . .|||||.|| ..|    ..  | |.|..|||| |.  .|.|.||||||      ||| .| ..| .|  .|. ..||||.||     |.    |
ecefvnkvygfyeecqkryqsvrmyaafqdvfnwlpltgliatkilcmhgglsplltkeftldtlrkiersteg.kerlvadllwadpisglsgfmenqr

GAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFD
|||  ||.|          | |. ||||.| .||..   |..||||||| || .  | ||.|  |. |. ||  . 
gagcgfgrdavlklcsefkldlvcrahqvvqdgyeffagrklvtifsaphycgqfdncaafmscdeklqcsfeilr
subfamily_Cele-PPP-4C_pd Subfamily Cele-PPP-4C 19-291 5.3e-86 281.2 In-house 5-275 (280) alignment 
Range on Protein: 19-291
Range on HMM: 5-275/280.0
CkqLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHE
|  ..| ..... |  |.||| .. . ||..||.||||.|||. ||. ||   .  |..||||.||||||| . .| . ||.. |||| ... |||||||
c..ikeadidrviekckkiltaqatmvevdapvavcgdlhgqytdllrlfarvsfppdqnylflgdyvdrgrqqlevillllaykvrypnnflilrgnhe

SRQITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPD-DRGGWGISPRGAGY
  .| . |||.||. |.| . .... | .|.| |||.||| |.|.|.|||||. . .||... | |  . ..|    ||||.||. .  ||. ..||. .
visinrkygfkdevkrrysl.alynefqelldslplvalvsgrilcmhgglsqklvslddlaelrrpfdsedeclamdllwadpenkvtgwaensrgvsv

TFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPA
 ||...   . .   . || | ||.| .||..  |...||.||||.|.    |.||.. .|. |. ||  . ||
ifganvvkdltekldidliarghqvvqdgyeffadkklvtvfsapkylgefdnsaavlivderlivsfevlkpa
subfamily_Cele-PPP-1A_pd Subfamily Cele-PPP-1A 19-289 2.1e-83 273.1 In-house 4-281 (284) alignment 
Range on Protein: 19-289
Range on HMM: 4-281/284.0
CKQ-LQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRS------PNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERIT
|.. |.|... .||  |.|.. ||.  .|...||...||.|||| ||. |. . |         ...|||.||||||| .|.| .||| ..|... ....
cqkllkekelielcyrarelfwkeklkleieapvkivgdihgqfedllalldlngwpfvedeakekkylflgdyvdrgpfsievitllfayklllpdkvf

ILRGNHESRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGI
.|||||||| . . |||| || ..| .| ... |   |  .||.|.|. .|.|.|||.|  .  |. . .|.|  ..|  | ..|| |.||. .  |.  
llrgnhesrpvnmqygfyleckkrysea.lyeafqlafnamplcavvskkiicmhggisedlldlkqldklerpidipdigviadltwadpeaevegyke

SPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFD
|||||| .||..  . |..   | |. ||||.||.||..  ||..||||||| || .  | ||....|. |  ||  . 
sprgagkvfgakavkeflkkfkldlvvrahqvvmdgyeffadrklvtifsapsycgqldniaavlnvdeelvasftvlk
subfamily_Cele-PPP-2B_pd Subfamily Cele-PPP-2B 19-292 3.7e-76 249.2 In-house 3-276 (280) alignment 
Range on Protein: 19-292
Range on HMM: 3-276/280.0
CKQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHE
|. .   ..  .  | . |. .|||. | ..|. | ||.| |..|.  || . || |. . .|.|||||||   .| . ||.|||.|||.|| .||||||
cnvmtgheiiaiirmveaifmeesnlceaeapikvigdihaqyqdmnrlfdligrvpeeklmflgdyvdrgpqgievlillfclkiryrdriyllrgnhe

SRQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGY
.  . ..|||| ||  ||| . .|  |   |. .|...|.  ...|.|||||| .  || || . |  |    | . ||||||| ..| ||  | ||  |
tpsvnkiygfyvecqykygvg.lwwdfqscfnrmpmsgliskrvlcmhgglspelinldtirniprpcepldrgllidllwsdptnkgegwfhsirgisy

TFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAP
 ||. . |   .|  . || ||||.| .||.    | ..|.|| |||| .  | ||.. |.  |. || |. | |
mfgkgvveqacksleidliirahqvvqdgyemmagrrlitvfsvpnycaqftnaaavvclnanlqvsfqqlippp
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 19-72 4.6e-13 42.0 In-house 5-59 (317) alignment 
Range on Protein: 19-72
Range on HMM: 5-59/317.0
CKQ-LQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGG
|.. ..|... .||  |.|.. ||    |...|||..||.||||.||. |. . |
cqdlfkekelielcyrarelfwkeplkleleapvtivGdihGqfedllalldlnG
subfamily_PPP1C_pd Subfamily PPP1C 20-289 6.2e-107 350.0 In-house 8-277 (282) alignment 
Range on Protein: 20-289
Range on HMM: 8-277/282.0
KQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHES
 .|.|.....|...|.|||.... . |.. ||...||.|||..||. || ..|  |..||||.|||||||  |.||..||...|..| |.. .|||||||
vklkeaeieallkkareillsqpilleleaPvkivgdihGqyadllrlfetsgaPpesnylflGdyvdrGkqsletivlllaykikypenlfllrGnhes

RQITQVYGFYDECLRKYGNAnVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYT
 .|...||||||| |.|..  .|| ||| |..|||.|||| .|.|.||||||... |..|| . |  |||..| .|||||||||. . ||. . ||  .|
asinriyGfydeckrrysik.lWktftdvfnclPlaalvdekilcvhGGlspelksleqirkiqrPlevpekgllcdllWsdpdkevlgwsendrGvsft

FGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFD
||.|. |.| ..| | || ||||.| .||..  .|..||.||||||| . .|..|....|. |. ||  . 
fgkdvvekflqkndldlivrahqvvedGyeffakrqlvtvfsapnycgefdnagavlsvdeellvsfqilk
subfamily_Cele-PPP-Subfam3_pd Subfamily Cele-PPP-Subfam3 20-290 2.2e-77 252.8 In-house 8-281 (287) alignment 
Range on Protein: 20-290
Range on HMM: 8-281/287.0
KQLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHES
. ...... .. | ..|||   . . ||. |.|..||.|||..||. .|   |..|...|||.|||||||  |.| . || .||..| ... .|||||| 
dafsdkdilevlekieeileplpalleveapitivGdihGqlddllrifnavGaapkvqylflGdyvdrGakslevslllfslkiaypkkvhllrGnhev

RQITQVYGFYDECLRKYGnANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQ--EVPHEGPMCDLLWSDPDDRgGWGIS---PRG
..| ..|||..|  ||..  ...| | |.|..||| | |. .|.|.|||.|| ...|| ..|| . .     .|| . ||||.||.     ..     |.
kkinklyGfkeelkrkrq.erlykqfndvfselplcarvskrilcmhGGispklksldslkalkkpttplacdeglqvdllwadpekd.aktfelnkira

AGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDP
    ||.   . . .  .. || |||... |||..  |...||.|||| |. .  | .|.. ....|. || .. |
isvvfGkkevddllkkldidlivrahevseeGyaflfdkrlvtvfsapyysgedtnlgavvvvskslelsfvvlkp
subfamily_Cele-PPP-3B_pd Subfamily Cele-PPP-3B 21-290 2.9e-69 226.3 In-house 15-288 (290) alignment 
Range on Protein: 21-290
Range on HMM: 15-288/290.0
QLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESR
 ...... .. | ..|||     . ||. |... ||.|||. .|.. |   |. |. ..||.|||||||  |.|   || |.|.|| ... .|||||| |
afsdkdileilekieeileplpalleveapivivgdihgqldallryfdavgyppkvkflflgdyvdrgakslevslllfcykiryskkvhllrgnhevr

QITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR--IQEVPHEGPMCDLLWSDPDD--RGGWGI-SPRGA
.. ..|||..|  ||  ....|| . |.|. |.| | |. .|.|.|||.|. |.. . ..|| .  ..   .|| . ||||.||.        .   |. 
kvnrlygfkeelarkr.gsrlwkqyqdvfaelslcarvgrkilcmhggisqkiesweslkalkkprvpltcdeglqvdllwadptrdkddtialnkqrai

GYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDP
   ||..  ... .  .| || |||..  ||.|.  |...||.|||| |. .  |  ||... ..|. |.  . |
svvfgkkglddllkklalslivrahevkeegfnflfdkklvtvfsapyysgndtnlgaiatvseslelsivvlkp
subfamily_Cele-PPP-5_pd Subfamily Cele-PPP-5 21-284 6.8e-58 189.2 In-house 5-293 (302) alignment 
Range on Protein: 21-284
Range on HMM: 5-293/302.0
QLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRS-----------PNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRER
....... .|.|.  | | ||... |.  |||. ||.||||.||. ..     .            .  ..|.|||||||. |.| ..|. .||| |...
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

ITILRGNHESRQITQVYGFYDECLRKYGNAN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-IQEVPHEGPMCDLLWSDPDDR
  .||||||.. |   ||| .|   ..|...   .|. | . | ..||.|||  .|.|.|||.|| ...|..|. ..| ..|| ..    |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

GGWGISPRGAGYTFG--QDISETFNHS--------NGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYS
 .  . ..   |..   ...| .||..         .| || |||| . ||...  |....||||||.|     |. |....|   | |
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
subfamily_Cele-PPP-Subfam5_pd Subfamily Cele-PPP-Subfam5 21-284 1e-57 188.6 In-house 6-294 (302) alignment 
Range on Protein: 21-284
Range on HMM: 6-294/302.0
QLQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRS-----------PNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRER
....... .|.|.  | | ||... |.  |||. ||.||||.||. ..     .            .  ..|.|||||||. |.| ..|. .||| |...
eysksellllieaviellkkektlaeispPvtivGdihGqfedlvrilnarvskeeakkksaysfssdkfvflGdyvdrGsksieciclvfalkvlyptn

ITILRGNHESRQITQVYGFYDECLRKYGNAN---VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDR-IQEVPHEGPMCDLLWSDPDDR
  .||||||.. |   ||| .|   ..|...   .|. | . | ..||.|||  .|.|.|||.|| ...|..|. ..| ..|| ..    |||..|| | 
yillrgnhetkainfaygfreelenrlgkkdgkeiwekfnevfsfmplaalvgekilcvhggispklesledikkikrplkevtedslaqdllfadpldv

GGWGISPRGAGYTFG--QDISETFNHS--------NGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYS
 .  . ..   |..   ...| .||..         .| || |||| . ||...  |....||||||.|     |. |....|   | |
qllaavsekPkyaknivrglsvvfneaavrdvckrlnlklivrahqmiPeGfkffadkklltifsaprymnesdnkGavlkvdtngkls
PPP_3 22-289 1.1e-120 394.7 In-house 2-270 (271) alignment 
Range on Protein: 22-289
Range on HMM: 2-270/271.0
LQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQ
|.||..|.|....||||.||||..|.. |||||||.|||..||.|||..||.||.|.|||.|||||||..|.|...||..||..| .....|||||||||
lsenelkelvkklkeilekesnlveisapvtvcGDiHGqldDLlelfknggpspetkYlFlGdyVDrGkkslEvlllLlalkikypkevhLlRGnhEsrq

ITQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL-LWSDPDDRGGWGISPRGAGYTFG
|..||||..|.|.|.|...|.|.....|..|||.||.|......||||||||..||.|. |.| .|||.||...|| |.|||....|.. |.||||..||
inkvYgFkkevlkkkggkkvykklqevFelLplaalidekvlvvHGGlspsiksldqikklerkievpeegklldlllssdpekeeglenskrGagllFg

QDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFD
.|..|.|...| |.|| |||.|..|||. .||..|||.|||||||.|..|..||..|..||...| |..
pdvteefleknkLkliiRaHelkeeGyeilhdgkvvtvfSapnycerasnagailkleealtsefkqle
subfamily_Cele-PPP-Subfam2_pd Subfamily Cele-PPP-Subfam2 22-293 3.3e-85 278.7 In-house 8-279 (281) alignment 
Range on Protein: 22-293
Range on HMM: 8-279/281.0
LQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQ
. ..... .  ... |...|... |.. |..| ||.|.||.|| .|| . || |.. ..|.|||||||  |.|.. || .||.|||.|| .||||||  .
ytkeeienvireveaifseekaLveidkPivvvGdlhaqfndlkrlfellgrvpeevlvflgdyvdrgpqslevlillftlkiryrdrivllrgnheias

ITQVYGFYDECLRKYGNaNVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDRG-GWGISPRGAGYTFG
. ..|||| ||  |||  ..|  |   |. ||..||.. .. |.|||||| . .||..|   .  . .. | . ||||.|||... .|  | ||...|||
vnkiygfyvecvtkyGe.elwalfqrcfnrlpisaliakrvlcmhGGlsPeltaldelrnrpkpirnldrGlviDllwadpdnkveewkassrGssftfG

QDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAPR
... .    . .. || ||||.|..||.    |...|.||.||||    | ||.. .|..|. |.... ||. 
knvvddvckrleveliirahqvvqdGyevlsgrklitvfsvpnycafyknaaavlkvdetlgislvalvpase
subfamily_PPZ_pd Subfamily PPZ 22-290 1.5e-82 270.4 In-house 25-293 (300) alignment 
Range on Protein: 22-290
Range on HMM: 25-293/300.0
LQENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQ
|..... ..|  |.|..  . .. |.  .| . ||||||. ||. ||   |  | .||||.|||||||  |.||. ||.| |..| | . .||||||  .
lknseilqicikarelflaqpallelspsvkivgdvhgqyadllrlftkcgfppsanylflgdyvdrgkqsletillllcykikypenffllrgnhecan

ITQVYGFYDECLRKyGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFG
.|.|||||||| |.  | ..|| | | |. |||.|.| |.|||.|||||| ....| || . |  .||  | . ||||||| |    |    ||  | . 
vtrvygfydeckrr.cnikiwktfvdtfntlplaaivagkifcvhgglspvlnsmdeirhvvrptdvpdfglindllwsdptdssnewednergvsycyn

QDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDP
.   . |    |. |. ||| .| .||..  ||..||.|||||||    |  |.| . . |  ||  .||
kvainkflnkfgfdlvcrahmvvedgyeffndrslvtvfsapnycgefdnwgavmsvsegllcsfelldp
PPP_1 23-277 1e-118 388.4 In-house 2-264 (264) alignment 
Range on Protein: 23-277
Range on HMM: 2-264/264.0
QENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQI
.|.....|....||.|.||.|..||. ..|||||.||||.||..||..|| ||.|||||.|||||||..|||...||..||..|......|||||||||.
eeeelaelkkklkellnkeenllevseeitvcGDiHGqfdDLlklfkvggpspetnYlFlGDyVDRGkdSvEilllLlalklkypkelfllRGNHEsrqv

TQVYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL--------LWSDPDDRGGWGISPRG
|.||||..|.|.|.......|..||.||.|||.||.|..|...||||||..|.||.|| ..| .|||.||..|||        |..|.......  |.||
tkvygFkkEvlkkkyskeiyktltdvFdvLplaalidekilivHGGlspeldlldqirkerrktevpeegklcdllekdvdillsddkeqeeavansiRG

AGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMEL
|||.||.|..|.|...|.|.|| |||....|||.....|.|||||||.||.....|..|...|
agylfgkdvtekflqknnlkliiRaHevkeeGyeflkkrkvvtifsasnyyeegsnrgayvkl
PP2Ac_SM00156 23-291 1.4e-110 361.6 In-house 2-270 (271) alignment 
Range on Protein: 23-291
Range on HMM: 2-270/271.0
QENQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQI
....|..|.| .||||..|.|. ||. ||||.||.|||..||..|.. .|..|...|.|.|||||||..|.|...||..||..| |....|||||||...
skeevlelleevkeilkqeknlvevsapvtvvGdihGqlddllrllelageppeekyvFlGdYVDRGpqsiEvillLfalkilypekvvLLRGnHEsssv

TQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDP-DDRGGWGISPRGAGYTFGQ
...|||..|. ||| ...... |...|..|||.|||| .|.|.||||||.. .||.|| |.| .| |.||...||||||| ..  |. .| ||....||.
nkiygfeeevkrky.gkeiyekfeeafsllPlaalvdskilcmhGGlspeleslddirklkrvkekpeegllidllwsdpeqkekgfqpskrglsvvFge

DISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPA
|. . | ..| | || |||..|.|||....|...||||||||||....|.||.......|| |. |....
davkeflkknnlkliiRahevvdeGyeffadkklvtifsapnycdefsnkaavlkveknlklsieqlkeq
subfamily_Cele-PPP-4A_pd Subfamily Cele-PPP-4A 25-290 1.2e-71 234.4 In-house 6-273 (284) alignment 
Range on Protein: 25-290
Range on HMM: 6-273/284.0
NQVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQITQ
..|. |   | .|. |.  . ||. |. .|||.|||| ||. ||   |    .||||.||||||| . .||. ||.. || . ... .||||||   | .
edvetllfhafsifnkqpmlievnspinicgdihgqfsdllrlfdkngfphranylflgdyvdrgkhcletilllfaykvifpnhffmlrgnhecslink

VYGFYDECLRKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPM-CDLLWSDPDD-RGGWGISPRGAGYTFGQD
.||||.|| |.| .  |.. |  .|  .||||||  .|.|.|||.|  .. . ..||. |  . |    .  |.||||| . . ||    ||  | || |
iygfyeecqrrynkpsvyvsfegvfsvmpltalvgqrilcmhggvskmlqnvsqlraikrpfdnpepntlaidilwsdptnfqkgwnpnsrgvsyvfgsd

ISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDP
    .     . |. ||||.| .||..  .| .||||||| || .  | ||.| ..  |  ||. . |
alrklldrlqidlvvrahqvvqdgyeffanrrlvtifsapfycgqfdnaaavmyvnknlvcsfvvlrp
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 26-72 3.9e-07 22.4 In-house 15-61 (339) alignment 
Range on Protein: 26-72
Range on HMM: 15-61/339.0
QVKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGG
..  ||  |.|..  |  . ....|. | ||.|||| ||. .. . |
elaelchrareliwsepiflkleapicvmgdihgqfddllamldmng
subfamily_Cele-PPP-2A_pd Subfamily Cele-PPP-2A 27-292 7.4e-67 218.7 In-house 25-293 (307) alignment 
Range on Protein: 27-292
Range on HMM: 25-293/307.0
VKHLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQITQVY
.. .   |. |.. |  . ..  |. | ||.|||| ||...| . || |.| |.| |||||||  |.|.. ||.. |. | | | .||||||  .. . |
fenviyeaqtifssekalvdidppcvvvgdlhgqfndlinmfillgrppetvyvftgdyvdrgllslecilllftykicypenivllrgnheiarvnkky

GFYDECLRKYGN--ANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDI
|||.||.    .   ..|  |   |. ||..||.  .|.|.||||||..  || .|   .    |  | . |.||.|||     |  | ||.|.||| ..
gfyeecvtsipkcgeeiwalfqrcfnnlpisaliatkilcmhgglspaltcldelrnhpkpirnpfrgivndmlwadpdpsvfewkassrgsgftfgtnv

SETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPAP
 .   .  |. || ||||....||     |...|||||| ||    |  ... .|..|    . | |. 
iddvckrlgveliirahqmcfdgywvlsgrklitifsapmycnfyknagcvlkvdetlgiqlvafvpes
subfamily_PPPLV_pd Subfamily PPPLV 29-277 1.8e-52 171.4 In-house 4-275 (290) alignment 
Range on Protein: 29-277
Range on HMM: 4-275/290.0
HLCEMAKEILTKESNVQEVKCPVTVCGDVHGQFHDLM----ELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQITQ
 ||..| .|| .| .. |.| |. | ||.||...||.     |.|.|     ...||.||||||| .||| .. |. ||| |  .. .|||||| . ...
slcdvavdilaaeerllelksptyvlgdlhgnyrdliyfekvlwrtgvdltpasllflgdyvdrgdfsveliayllalkvlypskvlllrgnhelesvqe

VYGFYDECLRKYGNA--NVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRI----QEVPHEGPM-CDLLWSDPDDR------------
 . .. |.  |.|.   .||. |.. ||.|||.| .| ..|| |.|.  .| |  .| |.. |    ..  .  |.  |.|||||..             
sieykgegsfkfgdsleevweafnnvfdalplaavidrkvfcvhagipraimtqayisaiqdilerlkddidgaplaldilwsdpaedrdlslrgelvln

-GGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRcGNQAAIMEL
 |    . || |. |..|  |.| . |.|  . |||.   .|..  ..  ..|.||. .||    |.||.. .
eGfvdndrrGtghvfsedaleaflkrnnlsfvlrahevkekGirlqqkgrlltvfsssrycGs.sneaalilv
subfamily_Cele-PPP-3A_pd Subfamily Cele-PPP-3A 45-290 1.9e-58 191.2 In-house 3-255 (263) alignment 
Range on Protein: 45-290
Range on HMM: 3-255/263.0
QEVKCPVTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNAN----
 |...|. .||| |||. ||. .|   | . .|.|||.||||||| .|.| . ||. ||.    .. .|||||| . | . |||. |  ...   .    
lelqapinicgdthgqyndllrifnacgaatktqylflgdyvdrgghslevimllfslklamprkmhllrgnhelkainknygfhaelkkrfqreevyes

VWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPM-CDLLWSDPDDrGGWGISP---RGAGYTFGQDISETFNHSNGLTLI
|...| ..| |.|| |.|  .|.|.|||.|| . .|| |||.    |  .  |. |||||.||.     |. |   |     ||.   . . .   . ||
vynhfnqvfsymplcaivskrilcmhggisphlkslddiraiplpletakthplacdllwadpek.dakgfepnkiraisnvfgkkevddlckrldidli

SRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDP
 ||||.|  || .  || ..|.|||  |     | ||.. ..  |. ||.|. |
vrahqvveygyaffadrrlitvfsasryqielcnyaavvvvnkmlelsfvqlkp
Metallophos Calcineurin-like phosphoesterase 50-242 1.2e-43 142.7 Pfam-A 2-198 (200) alignment 
Range on Protein: 50-242
Range on HMM: 2-198/200.0
PVTVCGDVHGQFHDL----MELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLL--VCLKVRYRERITILRGNHESRQITQVYGFYDECL----------
...|.||.||...||    ..|..|.........||.||.|||| .| ||  ||   .||...  ..  |||||||......|||..|.|          
rilvigDlHgglddledlllillkiaaeekpdlvlflGDlvdrgdwssetlalldylvlklllpipvfllrGNHesdpgnsaygflleqlkdlrglange

-----------------------RKYGNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLDHIraldriqevphegpmcdllwsdpddrggwgi
                       ..... ... .. . |..||| |||||.|.. ||.||.| .. | |                               
eeyenlkitllttsgelyglsglypllgdsaqeeqleeflalplralvdgkilltHgplsssggsgddi...............................

sprgAGYTFGQDISETFNHSNGLTLISRAHQL
    ... || |  | .   .|..|. |.|. 
....gselfgpdalekllekygvdlvlrGHtH
PPP_2 51-242 1.2e-80 262.9 In-house 1-197 (198) alignment 
Range on Protein: 51-242
Range on HMM: 1-197/198.0
VTVCGDVHGQFHDLMELFRIGGRSPNTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDLFD
||||||.|||..||..||. |..||...|||.|||||||..|.|...||..||..|......|||||||.....||||..|.|.|.|...|.|.....|.
vtvcGDlHGqldDLlilfknglpsperkylFlGdyvDrGkkslEvlllllalklvypkevhLlRGnhEskkvnkvygFkkevlkkkggkkvykklqevfe

YLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVPHEGPMCDL-----LWSDPDDRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQL
.|||.||.|......|||||..|..||.|.  .| .|.|.||...||     |..........  | ||||..||.|..|.. ..| |.|| |||..
lLplaalidekvlvvHGGlseeiklldqikkeerkiespeegklldlleeeklsdpkekeellansarGagllfgpdvteelleknklkliiRaHev
PPP_4 51-242 3.7e-76 248.6 In-house 1-196 (197) alignment 
Range on Protein: 51-242
Range on HMM: 1-196/197.0
VTVCGDVHGQFHDL-MELFRIGGRSP-NTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQITQVYGFYDECLRKyGNANVWKYFTDL
|||.||.|||..|| ..|...||. . ...|.|.|||||||..|.|...||..||..| .....|||||||......|||..|.|.|  .....|...|.
vtvvGDiHGqlddlllkllkngglpseersyvflGDyVDRGkdslevlllLlalklvypkevvllRGNHEskslnllygfkkevlek.hgkeilkklqdv

FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVP-HEGPMCDL-LWSDPD-DRGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQL
||.|||.||.|......|||||.....||.|....| .|.| .|. ..|| |||||  .  |.  | ||||..||.|. |.| ..|.| || |.|.|
fdllplaalidekvlvvhgglsdelesldkierierkiespleeekrkdlllwsdpreaqeglansvrGagllFgpdvtekfleknnlkliirshel
PPP_5_Dcr2 51-242 5e-75 244.9 In-house 1-198 (199) alignment 
Range on Protein: 51-242
Range on HMM: 1-198/199.0
VTVCGDVHGQFHDL-MELFRIGGRSP-NTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQITQVYGFYDECLRKYGNANVWKYFTDL
||||||.|||..|| ..||. ||. . ...|.|.|||||||..|.|...||..||..| .....||||||..|....|||..|.|.||......|...|.
vtvcGDlHGqlddlllilfkeggdpseerlyvFlGDyVDrGkdslevlllLlalklvypkevhllrGNHEdeqlneiygftkevlskyhgkkiykilsdv

FDYLPLTALVDGQIFCLHGGLSPSIDTLDHIRALDRIQEVP-HEGPMCDL-LWSDPD-DRGG-WGISPRGAGYTFGQDISETFNHSNGLTLISRAHQL
||.|||.||.|......||||||.|..........| .|.| ..| ..|| |||||  .  | .  | ||||..||.|. |.| . |.| || |.|.|
fdwlPlaalidekvlvvhgglspeiksiellekierkieipeekgekadlllwsdprdaqegcklnseRGagllfgpdvtekfleknnlkliirshel
subfamily_YNL217W_pd Subfamily YNL217W 51-124 5.2e-10 32.2 In-house 12-81 (235) alignment 
Range on Protein: 51-124
Range on HMM: 12-81/235.0
VTVCGDVHGQFHDLMELFR--IGGRSPNTNYLFMGDYVDRGYYSVETVTLLvclkvrYRERITILRGNHESRQITQ
. | ||||| . .|.||.   |||. .|   ...|| ...|  |||.| ..       ..    ..||||   . .
llvvGdvhgaYDelieLlddkiggkdenvlvvlvGdlinkGPksvevvsyv......rkdqvkcvkGnheelvlla
subfamily_Cele-PPP-Subfam1_pd Subfamily Cele-PPP-Subfam1 76-291 5.8e-72 235.5 In-house 100-315 (317) alignment 
Range on Protein: 76-291
Range on HMM: 100-315/317.0
NTNYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDT
. .|||.||||||| .|.| |.||..||..| .....|||||||| . . |||| |. ..| .|.... |   |  |||.|.|. .|.|.|||.| ..  
ykkylflGdyvdrGpfsievvillfalkllypdkvfllrGnhesrpvntqyGfyrevkkry.saalyeafqlafnvlplcavvnkkilcmhGGiseelld

LDHIRALDRIQEVPHEGPMCDLLWSDPDDR-GGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAI
|. . .|.|  ..|  | ..|| |.||| .  |.  |.||||  ||..  . |..   | |. ||||.|..||..  ||..|||||||.|| .  | ||.
lkqldklkrpldipdvGvladltwadpdaevkgykesarGagkvfGakavkeflkkldldlvvrahqvvedGyeffadrklvtifsapsycGqldniaav

MELDDALKYSFLQFDPA
...|. || |.  . | 
lsvdkklkisinvlrpe
subfamily_Cele-PPP-1B_pd Subfamily Cele-PPP-1B 78-293 1.2e-56 185.3 In-house 121-336 (339) alignment 
Range on Protein: 78-293
Range on HMM: 121-336/339.0
NYLFMGDYVDRGYYSVETVTLLVCLKVRYRERITILRGNHESRQITQVYGFYDECLRKYgNANVWKYFTDLFDYLPLTALVDGQIFCLHGGLSPSIDTLD
 |||.||||||| .|.| | || .||. | .|| .|||||||| .   |||| |   .| .|.... | ..|. .|. |...  |.|.|||.|  . ...
rylflgdyvdrgpfsmevvilltalklaypdriyllrgnhesrsvntsygfyrevnyry.daqlyecfqnmfnvfpfcavinntimcmhggisehltsfn

HIRALDRIQEVPHEGPMCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIME
..  . |  |.|  | . || |.|||    |.  | ||| . ||     .| .   | .. | ||.| .||..   | .|||||||||| .  | ||.. 
qfsvfkrpleipdvgvltdltwadpdptekgykpsargasfvfgppalraflkkldlqmvirghqvvedgyeffdgrrlvtifsapnycgqndntaavfs

LDDALKYSFLQFDPAPR
.|  || |   | |  |
idkklkisinvfrpesr
subfamily_PPP7C_pd Subfamily PPP7C 194-291 6e-22 70.9 In-house 237-335 (383) alignment 
Range on Protein: 194-291
Range on HMM: 237-335/383.0
MCDLLWSDPDD-RGGWGISPRGAGYTFGQDISETFNHSNGLTLISRAHQLVMEGYNWCHDRNVVTIFSAPNYCYRCGNQAAIMELDDALKYSFLQFDPA
. |.|||||   .| .  . ||.|  || |... . .  .|.|. |.|.  .|||...||..|.||||| ||     |. | . | ..|.  ..|.  .
vldilwsdpkakeGckpntlrGgGsyfGpdvtkkllqkynlkllirsheckpeGyefvhdkkvltifsasnyyeeGsnrGayvklgkdltprivqyqas